Digital Commons Network^™

Developing Metabolism-Targeting Adjuvants To Immunotherapy In Murine Melanoma, Xinyi Zhang

Yale Graduate School of Arts and Sciences Dissertations

Melanoma is the deadliest skin cancer type, causing 8000 deaths per year in the United States. The development of immunotherapy significantly prolongs the survival of cancer patients, including patients with melanoma. By impairing the inhibitory signaling pathway, immunotherapy, for example anti-PD-1 monoclonal antibody, reinforces the anti-tumor effector function of T cells that recognize cancer cells and therefore suppresses tumor progression. However, the problem of low responsiveness and development of resistance significantly prevents a large proportion of patients from benefiting from immunotherapy. Therefore, it is of great importance to develop adjuvants to increase the efficacy of immunotherapy. Metabolic alterations have long …

Life Line Spring 2024, Otterbein Biology And Earth Science Department

Life Line - The Biology Department Newsletter

In this Issue:

The Department Welcomes Dr. Grooms; Otterbein's New Pollinator/Rain Garden; Alumni Return to Share Research; Svitana Serves on Ohio EPA VAP Rules Review Advisory Committee; Field Geology Students Explore Death Valley and the Grand Canyon; Students Volunteer at Remote Area Medical Clinic; The Mussels of the Stillwater River and Greenville Creek; More Than "Just" a Chickadee; An Enriching Time at the Zoo; Human Reaction Times; Using Computer Models to Inform Real World Control Methods in Street Dogs; Svitana Continues Work with NGWA; DIY Microbial Fuel Cell Challenge; Birds of a Feather...; Students Research Impact of Sunscreens on Corals; …

An Analysis On The Capacity Of Visual Art To Promote Conservation Efforts, Devi Bell

Honors Projects

In recent decades, we have become more aware of the ways in which anthropogenic actions are harming Earth’s climate, ecosystems, and overall stability. Scientists generally agree on the urgency of our situation, yet the public may find difficulty in comprehending the multitude of information on it. This study aims to educate the public on biodiversity loss and related ecological issues in Ohio by discussing these topics through the medium of visual art. Five pieces involving different scientific subject matter and art mediums were created and displayed for participants to view. Participants completed two surveys, one before viewing the art and …

How To Identify Various Sparrow Species, Aidan Castricone '24, Alexis Larsen '24, Emma Barry '25

Biology Student Scholarship

A helpful infographic on how to differentiate between four little brown birds: the house sparrow, the song sparrow, the white-throated sparrow, and the swamp sparrow. Animal behavior (BIO 350/350L) final project

Seven Behaviors Exhibited In The Blue Jay, Gillian Chapleau '24, Jide Owoeye '23

Biology Student Scholarship

A quick guide to understanding common behaviors exhibited by blue jays. Animal behavior (BIO 350/350L) final project

Blue Jays, Meriam Salo '25, Gabriela Guzman Reyes '24

Biology Student Scholarship

A guide to identifying blue jays, and understanding their common behaviors. Animal behavior (BIO 350/350L) final project

Mallards And Their Interesting Facts, Caitlin Mchugh '24, Jessica Slaton '24

Biology Student Scholarship

A guide on how to differentiate between male and female mallards, where to find these ducks, and their common behaviors. Animal behavior (BIO 350/350L) final project

Identifying The American Goldfinch, Margaret Low '24, Laura Mooney '24

Biology Student Scholarship

An infographic with tips on how to identify a common backyard visitor, the American goldfinch. Animal behavior (BIO 350/350L) final project

Assessing Forage Research And Education Needs Of Organic Dairy Farms In The United States, Eric Hatungimana, Heather M. Darby, Kathy J. Soder, Sara E. Ziegler, Andre F. Brito, Lisa Kissing Kucek, Heathcliffe Riday, E Charles Brummer

Faculty Publications

The viability of organic dairy operations in the United States (US) relies on forage production. The objectives of this study were to (1) assess producer and farm information regarding current forage production practices and producer knowledge gaps and (2) identify forage research and educational needs of organic dairy producers across the US. A survey was distributed to 643 organic dairy producers across the US, with 165 respondents (26% response rate). A focus group consisting of extension professionals, university researchers and staff, consultants, dairy industry representatives and organic dairy producers was also consulted for forage research needs. Results showed that approximately …

Assessing Forage Research And Education Needs Of Organic Dairy Farms In The United States, Eric Hatungimana, Heather M. Darby, Kathy J. Soder, Sara E. Ziegler, Andre F. Brito, Lisa Kissing Kucek, Heathcliffe Riday, E Charles Brummer

Faculty Publications

The viability of organic dairy operations in the United States (US) relies on forage production. The objectives of this study were to (1) assess producer and farm information regarding current forage production practices and producer knowledge gaps and (2) identify forage research and educational needs of organic dairy producers across the US. A survey was distributed to 643 organic dairy producers across the US, with 165 respondents (26% response rate). A focus group consisting of extension professionals, university researchers and staff, consultants, dairy industry representatives and organic dairy producers was also consulted for forage research needs. Results showed that approximately …

Gamma Delta T Cells In Acute Myeloid Leukemia: Biology And Emerging Therapeutic Strategies, Adishwar Rao, Akriti Agrawal, Gautam Borthakur, Venkata Lokesh Battula, Abhishek Maiti

Faculty, Staff and Student Publications

γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. AML shows high expression of phosphoantigens and UL-16 binding proteins that activate the Vδ2 and Vδ1 subtypes of γδ T cells, respectively, leading to γδ T cell-mediated cytotoxicity. Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of …

Novel Ancestry-Specific Primary Open-Angle Glaucoma Loci And Shared Biology With Vascular Mechanisms And Cell Proliferation, Valeria Lo Faro, Arjun Bhattacharya, Wei Zhou, Dan Zhou, Ying Wang, Kristi Läll, Masahiro Kanai, Esteban Lopera-Maya, Peter Straub, Priyanka Pawar, Ran Tao, Xue Zhong, Shinichi Namba, Global Biobank Meta-Analysis Initiative, Serena Sanna, Ilja M Nolte, Yukinori Okada, Nathan Ingold, Stuart Macgregor, Harold Snieder, Ida Surakka, Jonathan Shortt, Chris Gignoux, Nicholas Rafaels, Kristy Crooks, Anurag Verma, Shefali S Verma, Lindsay Guare, Daniel J Rader, Cristen Willer, Alicia R Martin, Milam A Brantley, Eric R Gamazon, Nomdo M Jansonius, Karen Joos, Nancy J Cox, Jibril Hirbo

Faculty, Staff and Student Publications

Primary open-angle glaucoma (POAG), a leading cause of irreversible blindness globally, shows disparity in prevalence and manifestations across ancestries. We perform meta-analysis across 15 biobanks (of the Global Biobank Meta-analysis Initiative) (n = 1,487,441: cases = 26,848) and merge with previous multi-ancestry studies, with the combined dataset representing the largest and most diverse POAG study to date (n = 1,478,037: cases = 46,325) and identify 17 novel significant loci, 5 of which were ancestry specific. Gene-enrichment and transcriptome-wide association analyses implicate vascular and cancer genes, a fifth of which are primary ciliary related. We perform an extensive statistical analysis of …

Drivers Of Anticoagulant Rodenticide Exposure In Fishers (Pekania Pennanti) Across The Northeastern United States, Georgianna Silveira, Jacqueline L. Frair, Lisa Murphy, Julie C. Ellis, David Needle, Stephanie A. Cunningham, Amanda Watson, Aaron Facka, Patrick Tate, Shevenell Webb, Kim Royar, Chris Bernier, Thomas Keller, Krysten Schuler

Faculty Publications

Studies in parts of Europe, New Zealand, and North America indicate uptake of anticoagulant rodenticides (ARs) by predatory mammals to be widespread and common, with proximity to urban and agricultural areas being an important driver of exposure. Yet, little is known regarding the patterns and drivers of AR exposure in predatory mammals within more forest-dominated landscapes. Across the forest-dominated northeastern United States (US), a region spanning Pennsylvania to Maine, we tested livers from 597 fisher (Pekania pennanti) obtained from the legal harvest for 11 anticoagulant rodenticide compounds. We used kriging to determine potential hot zones (within or among states) and …

Drivers Of Anticoagulant Rodenticide Exposure In Fishers (Pekania Pennanti) Across The Northeastern United States, Georgianna Silveira, Jacqueline L. Frair, Lisa Murphy, Julie C. Ellis, David Needle, Stephanie A. Cunningham, Amanda Watson, Aaron Facka, Patrick Tate, Shevenell Webb, Kim Royar, Chris Bernier, Thomas Keller, Krysten Schuler

Faculty Publications

Studies in parts of Europe, New Zealand, and North America indicate uptake of anticoagulant rodenticides (ARs) by predatory mammals to be widespread and common, with proximity to urban and agricultural areas being an important driver of exposure. Yet, little is known regarding the patterns and drivers of AR exposure in predatory mammals within more forest-dominated landscapes. Across the forest-dominated northeastern United States (US), a region spanning Pennsylvania to Maine, we tested livers from 597 fisher (Pekania pennanti) obtained from the legal harvest for 11 anticoagulant rodenticide compounds. We used kriging to determine potential hot zones (within or among states) and …

The Nitrogen Footprint Of Ukraine: Why Personal Consumption Matters, Sergiy Medinets, Allison M. Leach, Tetiana Pavlik, Volodymyr Medinets, James N. Galloway

Faculty Publications

Unintended reactive nitrogen (N) losses from agriculture, energy and transportation pose significant environmental hazards, including eutrophication, acidification, water and air pollution, biodiversity loss, human health risks and climate change. The concept of a nitrogen footprint (NF) emerges as a pivotal metric, reflecting potential N losses in the entire production-consumption chain of goods and services used by an individual within a defined timeframe.In a pioneering assessment of per capita NF in Ukraine, key factors, such as the food production chain, consumption patterns, connection to wastewater treatment (WWT) system and the efficacy of WWT facilities, were identified as critical components. Addressing specific …

Making The Connection: How Membrane Contact Sites Have Changed Our View Of Organelle Biology, G. Voeltz, E. Sawyer, G. Hajnóczky, W. Prinz

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The view of organelles and how they operate together has changed dramatically over the last two decades. The textbook view of organelles was that they operated largely independently and were connected by vesicular trafficking and the diffusion of signals through the cytoplasm. We now know that all organelles make functional close contacts with one another, often called membrane contact sites. The study of these sites has moved to center stage in cell biology as it has become clear that they play critical roles in healthy and developing cells and during cell stress and disease states. Contact sites have important roles …

Zooming In On Zebrafish Findings, Lydia Post

The Voice

No abstract provided.

Female Biology, Jennifer Dever

All USF Faculty Authored Books

Over twenty years ago I developed a course for the upper- level biology major at the University of San Francisco called

Female Biology. This was from what I perceived as a gap in the undergraduate biology curriculum- students were not learning about the evolutionary aspects of being female and studying the specific health-related issues unique to women. The information in the most widely used general biology textbooks written from a male perspective, focuses on research gained from male models by work conducted in male-led laboratories. There still exists a problem with a lack of adequate representation of women in biomedical …

Lifelines Winter 2024, Southern Adventist University

Lifelines - Biology Department Newsletter

The Spring 2023 issue of Lifelines contains articles on an alumni spotlight, department events, biology and allied health graduates, and Ann Foster.

Biol 382-002: Animal Behavior, Caroline Devan

Biology Syllabi

No abstract provided.

Biol 498-002: St: The Neuron's Forgotten Sibling, Jorge Golowasch

Biology Syllabi

No abstract provided.

Biol 698-004: St: The Neuron's Forgotten Sibling, Jorge Golowasch

Biology Syllabi

No abstract provided.

Nsp3 Protein-Portion Interaction Of Sars-Cov-2 Using Two Yeast-Hybrid System, Ghadeer Jassem Zakareya

Selected Full-Text Master Theses 2021-

The NSP3 protein of SARS-CoV-2 plays a crucial role in the virus-host interaction during infection. This thesis explores the protein-protein interactions between NSP3 and host factors, shedding light on their significance in viral replication and pathogenesis. NSP3 is known to interact with various host proteins involved in key cellular processes, including innate immune response modulation, RNA processing and protein degradation pathways. Understanding these interactions is essential for developing targeted therapeutic strategies against COVID-19. Application of The Matchmaker GAL4Two-Hybrid Systems, to isolate the NSP3 protein and study the interactions, elucidating the NSP3 host protein interactions and attempting to identify potential key …

Creation Of A Digital Storage System For Genome Sequencing Metadata, Jacquelin W. Olexa

Undergraduate Theses, Professional Papers, and Capstone Artifacts

As the field of computational genomics continues to expand in both potential and application, it is now more imperative than ever to ensure that massive genetic sequencing datasets are properly stored in an accessible manner. This project sought to establish a practical, user-friendly, secure system for a genomics research lab (the Good Lab; thegoodlab.org) at the University of Montana. A MySQL database and connected web application was ruled the best configuration to maximize utility and accessibility for the lab’s researchers. Building the logical framework for the database, creating the server, and sourcing data occurred over several months. The dataset ranged …

Ai In Education: Investigating The Potential Of Artificial Intelligence (Ai) To Support Biology Teachers In Improving Their Pedagogical Practices To Teaching Topics Perceived As Difficult., Silas Otiende Ouma

Master of Education

Ensuring learner engagement is crucial for achieving conceptual understanding, especially in biology classes. In Kenya, a noticeable decline in average biology scores, and insights from studies indicate that there is a dominant use of teacher-centered teaching methods which rarely engage learners to enable them to comprehend some of the biology topics that are marred with complexity. This research aimed to explore the potential of Artificial Intelligence (AI) to support biology teachers in improving their pedagogical practices in teaching topics perceived as difficult. The study began by exploring the perceived difficult topics in biology, the current pedagogical approaches used to teach …

Biol 337-002 Collective Intelligence In Biological Systems, Simon Garnier

Biology Syllabi

No abstract provided.

Biol 475-H02, Maria Stanko

Biology Syllabi

No abstract provided.

Differential Photosynthetic Yield And Accumulated Degree Day Estimation For Parrotfeather (Myriophyllum Aquaticum) To Determine Invasive Potential In The Midwest, United States, Alyssa Anderson

All Graduate Theses, Dissertations, and Other Capstone Projects

Thank you to the Aquatic Plant Management Society (APMS) and affiliated chapters for funding this project. I would like to thank Mississippi State University for sending my source parrotfeather for propagation throughout the course of this project. Thank you to Jenna Eklund, Allison Squires, Thomas Zellmer, Justin Kjorness, and others in the Weed Science lab for their assistance. Finally, I would like to extend my thanks and gratitude to my committee members: Ryan Wersal, PhD, Christopher Ruhland, PhD, and Gray Turnage, PhD for their everlasting support and guidance throughout this project.

Asynchronous Movement Patterns Between Breeding And Stopover Locations In A Long-Distance Migratory Songbird, Theodore Zenzal, Andrea Contina, Hannah Vander Zanden, Leanne Kuwahara, Daniel Allen, Kristen Covino

Faculty Publications

The species-specific migratory patterns and strategies of many songbirds remain unknown or understudied, as research in animal ecology is biased toward the breeding period, with the fewest studies on the migratory period across taxa. Identifying large-scale spatiotemporal migratory patterns is challenging, as individuals within a species may vary in their migratory behavior and strategies. The Yellow Warbler (Setophaga petechia) is a Nearctic-Neotropical migrant that is relatively well studied during the breeding season, but its species-wide migratory patterns remain understudied. Our aim in studying Yellow Warbler movement ecology was to characterize temporal migration patterns during fall migration. We sought to determine …

Localization And Quantification Of Atpase, Ca2+ Transporting, Plasma Membrane 2 (Atp2b2) In The Developing Euthyroid And Hypothyroid Cochlea, Emily Gregersen

All Graduate Theses, Dissertations, and Other Capstone Projects

Thyroid hormone (TH) is essential for auditory system development. Proper auditory function requires remodeling and transformation of cochlear structures during a critical developmental period. In rodent models, low TH during this timeframe delays remodeling and impacts ion channel function required for hearing to occur. TH receptors are ligand-dependent transcription factors that regulate expression of genes. Considering this, auditory deficits observed in hypothyroidism are thought to be largely the result of altered expression of specific TH receptor target genes. TH is reported to impact calcium signaling in several tissues, but whether regulators of calcium signaling are altered following developmental hypothyroidism is …