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Artificial intelligence

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The Research University, Industry And Artificial Intelligence, Hamlet Isakhanli Aug 2025

The Research University, Industry And Artificial Intelligence, Hamlet Isakhanli

Khazar Journal of Humanities and Social Sciences

Scientific research in cooperation between science and industry occurs mainly in research universities. This article begins with a brief history of research universities, a discussion of their nature and form. Their evolution and development in Europe, the USA and China are recalled; the special importance of Graduate Schools is underlined. Cooperation between the worlds of university and industry is studied using the example in the USA of Silicon Valley, a world leader in its field and initiated by Stanford University. Presented alongside the positive American experience, is the rather negative experience of the ``Russian syndrome''. The development of semiconductor, transistor …


Robot Prosecutors And The Future Of Criminal Justice In Indonesia: Innovation, Ethics, And Legal Implications, Kurnia Dewi Anggraeny, Zico Junius Fernando, Kasmanto Rinaldi Aug 2025

Robot Prosecutors And The Future Of Criminal Justice In Indonesia: Innovation, Ethics, And Legal Implications, Kurnia Dewi Anggraeny, Zico Junius Fernando, Kasmanto Rinaldi

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Robot prosecutors represent the integration of robotic technology and artificial intelligence (AI) into the traditional role of a prosecutor, reflecting the global trend towards automation and the application of technology within the legal system. This concept is no longer merely a theoretical; it has begun to materialize in certain jurisdictions. For instance, China has emerged as a pioneer in this field by successfully developing an innovative AI program capable of not only of identifying crimes through detailed data analysis but also of filing appropriate lawsuits. This progress underscores the immense potential of this technology to enhance efficiency and accuracy in …


Mathematics And Mental Health: An Interdisciplinary Analysis Of Ai In Counselor Education, Jennifer M. Hightower, Catrina A. May Aug 2025

Mathematics And Mental Health: An Interdisciplinary Analysis Of Ai In Counselor Education, Jennifer M. Hightower, Catrina A. May

Journal of Counselor Preparation and Supervision

Although use of Artificial Intelligence (AI) in mental health care has become increasingly common, many professional counselors remain under informed about foundational components of AI. Fundamental issues associated with AI, including model bias and the Black Box Problem, must be considered as these tools become integrated into the counseling profession. This manuscript provides an interdisciplinary, theoretical analysis of AI use in counseling and counselor education grounded in foundational knowledge of AI and the American Counseling Association’s recommendations for the ethical integration of AI (Butler et al., 2023). The paper summarizes these recommendations, establishes accessible definitions of AI terms, explains the …


Digital Testing And Evaluation: Current Status, Challenges, And Prospects, Bo Sun, Kai Zheng Aug 2025

Digital Testing And Evaluation: Current Status, Challenges, And Prospects, Bo Sun, Kai Zheng

Journal of System Simulation

Abstract: Digital testing and evaluation (DTE) represents a novel paradigm in the evolution of testing and evaluation methodologies within the digital era. It is achieved through the integration of multiple digital theories and technologies to conduct testing and evaluations in the digital domain. This paper analyzed the characteristics of test objects across different historical periods, reviewed the core features of testing and evaluation techniques in each stage, and unveiled the paradigm shifts within the testing and evaluation technology system. Building upon this foundation, it explored the new demands placed on testing by test objects in the information age, clarifying the …


The Role Of Ai In Language Learning: Teachers' And Students' Experiences In Vocational High Schools, Cyntia Wahyu Khafidah, Ahmad Faruk Aug 2025

The Role Of Ai In Language Learning: Teachers' And Students' Experiences In Vocational High Schools, Cyntia Wahyu Khafidah, Ahmad Faruk

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to analyze the role of artificial intelligence (AI) in language learning in vocational high schools, focusing on the experiences of teachers and students. This study uses a qualitative approach with a case study method, where data are collected through observation and interviews. Vygotsky's constructivism theory is used as a basis for understanding how AI supports independent and interactive learning. The results show that AI improves students' speaking and listening skills through automated feedback and enables personalized learning. However, limited infrastructure and lack of training for teachers are major obstacles in implementing AI in the classroom. In addition, …


Introduction: Symposium ‒ Ai Disrupting Law, Edward Lee Aug 2025

Introduction: Symposium ‒ Ai Disrupting Law, Edward Lee

Chicago-Kent Law Review

No abstract provided.


The Files Are In The Computer: On Copyright, Memorization, And Generative Ai, A. Feder Cooper [email protected], James Grimmelmann Aug 2025

The Files Are In The Computer: On Copyright, Memorization, And Generative Ai, A. Feder Cooper [email protected], James Grimmelmann

Chicago-Kent Law Review

No abstract provided.


Artificial Intellectual Property, Daniel J. Gervais Aug 2025

Artificial Intellectual Property, Daniel J. Gervais

Chicago-Kent Law Review

No abstract provided.


Ai-Driven Biomedical Perspectives On Mental Fatigue In The Post-Covid-19 Era: Trends, Research Gaps, And Future Directions, Saba Parveen, Md Belal Bin Heyat, Umair Tariq, Faijan Akhtar, Hafiz Muhammad Zeeshan, Seth Christopher Yaw Appiah, Shang-Ming Zhou, Huang Lei Aug 2025

Ai-Driven Biomedical Perspectives On Mental Fatigue In The Post-Covid-19 Era: Trends, Research Gaps, And Future Directions, Saba Parveen, Md Belal Bin Heyat, Umair Tariq, Faijan Akhtar, Hafiz Muhammad Zeeshan, Seth Christopher Yaw Appiah, Shang-Ming Zhou, Huang Lei

School of Nursing and Midwifery

Mental fatigue is a complex condition arising from various neurological processes and influenced by external factors such as stress and cognitive demands. This comprehensive review elucidates the primary neurological mechanisms underlying mental fatigue, particularly emphasizing how it was elevated or otherwise affected during the COVID-19 pandemic. We explore the intricate relationship between prolonged cognitive tasks, chronic stress, and the development of mental fatigue, emphasizing the impacts that mental fatigue has on mental health across diverse populations. Utilizing advanced artificial intelligence techniques, including machine learning and deep learning, this study identifies and quantifies the patterns of mental fatigue. The innovative approach …


A Comprehensive Review Of Frugal Artificial Intelligence: Challenges, Applications, And The Road To Sustainable Ai, Nancy Girdhar, Aditya Raj, Deepak Sharma, Vinay Singh, Antoine Doucet, Matthias Renz Aug 2025

A Comprehensive Review Of Frugal Artificial Intelligence: Challenges, Applications, And The Road To Sustainable Ai, Nancy Girdhar, Aditya Raj, Deepak Sharma, Vinay Singh, Antoine Doucet, Matthias Renz

School of Engineering, Computing and Mathematics

Artificial Intelligence (AI) has demonstrated its transformative impact in creating learning models, processing extensive datasets, and executing intricate calculations rapidly. Nevertheless, achieving optimal performance with AI models demands substantial investment in powerful and expensive high-end hardware. The learning models running on the hardware are complex, requiring massive data and huge training time. However, the race to achieve higher accuracy and computational limitations of AI further poses a threat to the environment and thus provides motivation to develop AI technology that is cost-effective, scalable, and suitable for resource-constrained environments, Frugal Artificial Intelligence, or Frugal AI. The objective of this paper is …


The Lived Experiences Of African American First-Generation Higher Education Students In The Artificial Intelligence Chatbot College Admissions Process: A Transcendental Phenomenological Study, Felecia M. Williams Aug 2025

The Lived Experiences Of African American First-Generation Higher Education Students In The Artificial Intelligence Chatbot College Admissions Process: A Transcendental Phenomenological Study, Felecia M. Williams

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the lived experiences of African American first-generation higher education students as they navigate the AI chatbot college admissions process at universities throughout the United States. The theory guiding this transcendental phenomenological study is Rawl’s theory of social justice, as it explained the equal distribution of social values such as wealth, income, opportunity, and liberty. Van Manen's thematic analysis is used to explore the lived experiences and perspectives of the participants. The central research question for this study was, “What are the lived experiences of African American first-generation students who use …


Development And Validation Of Venous Thromboembolism-Bidirectional Encoder Representations From Transformers (Vte-Bert) Natural Language Processing Model, Omid Jafari, Shengling Ma, Barbara D Lam, Jun Y Jiang, Emily Zhou, Mrinal Ranjan, Justine Ryu, Raka Bandyo, Arash Maghsoudi, Bo Peng, Christopher I Amos, Abiodun Oluyomi, Nathanael R Fillmore, Jennifer La, Ang Li Aug 2025

Development And Validation Of Venous Thromboembolism-Bidirectional Encoder Representations From Transformers (Vte-Bert) Natural Language Processing Model, Omid Jafari, Shengling Ma, Barbara D Lam, Jun Y Jiang, Emily Zhou, Mrinal Ranjan, Justine Ryu, Raka Bandyo, Arash Maghsoudi, Bo Peng, Christopher I Amos, Abiodun Oluyomi, Nathanael R Fillmore, Jennifer La, Ang Li

Faculty, Staff and Students Publications

Background: Accurate and rapid phenotyping of venous thromboembolism (VTE) in longitudinal studies is important. A natural language processing (NLP) tool externally validated in representative patients is lacking.

Objectives: To train and validate an efficient NLP model to detect incident VTE event.

Methods: We designed a novel NLP platform, NLPMed, to assist thrombosis researchers with data preprocessing, phenotype annotation, language model finetuning, and NLP application. Using clinical notes, discharge summaries, and radiology reports from patients with cancer at 2 healthcare institutions, we finetuned Bio_Clinical Bidirectional Encoder Representations from Transformers (BERT) to develop VTE-BERT. The new model was trained to detect acute …


Farming With Data: Tracing Critical Tensions Using Data Science For Food Justice, Marc Sager, Maximilan Sherard, Anthony Petrosino Aug 2025

Farming With Data: Tracing Critical Tensions Using Data Science For Food Justice, Marc Sager, Maximilan Sherard, Anthony Petrosino

Publications

In this manuscript, we explore the intersection of artificial intelligence (AI) and equitable learning in higher education, focusing on data science as a subset of AI and social justice as the core theme of equity. Our investigation sheds light on the nuanced tensions inherent in employing data science for social justice. Rooted in situated perspectives of learning and consequential learning, our study employs an instrumental case-study methodology and analysis techniques from interaction and conversation analysis. Collaborating with three undergraduate students and an urban farm, the students used data science practices to highlight inequities surrounding food justice and access to food. …


The Use Of Ai In Canadian Courts, Shaughnessy Dow Aug 2025

The Use Of Ai In Canadian Courts, Shaughnessy Dow

Dalhousie Journal of Legal Studies

Like many other fields, there has been growing discussion about the potential benefits of AI for the law. In light of the Federal Court’s interim principles and guidelines on the use of AI, this paper considers whether AI applications can assist the judiciary with its decision-making function. In doing so, it starts by considering the role that judges play in our legal system, finding that they are often called upon to consider and weigh information with human, emotional qualities and to assess the broader policy implications of their legal rulings. This paper concludes that the optimism of proponents of AI …


Bibliography For "Ai 2.0: Is Ai A Tool, A Threat, Or A Teammate?", Annikah Carpio, Sally Park, Melody Madrigal Aug 2025

Bibliography For "Ai 2.0: Is Ai A Tool, A Threat, Or A Teammate?", Annikah Carpio, Sally Park, Melody Madrigal

Library Displays and Bibliographies

A bibliography created to support a display about AI 2.0 in August 2025 at the Leatherby Libraries at Chapman University.


A Review: The Beauty Of Serendipity Between Integrated Circuit Security And Artificial Intelligence, Chen Dong, Decheng Qiu, Bolun Li, Yang Yang, Chenxi Lyu, Dong Cheng, Hao Zhang, Zhenyi. Chen Aug 2025

A Review: The Beauty Of Serendipity Between Integrated Circuit Security And Artificial Intelligence, Chen Dong, Decheng Qiu, Bolun Li, Yang Yang, Chenxi Lyu, Dong Cheng, Hao Zhang, Zhenyi. Chen

Research Collection School Of Computing and Information Systems

Integrated circuits are the core of a cyber-physical system, where tens of billions of components are integrated into a tiny silicon chip to conduct complex functions. To maximize utilities, the design and manufacturing life cycle of integrated circuits rely on numerous untrustworthy third parties, forming a global supply chain model. At the same time, this model produces unpredictable and catastrophic issues, threatening the security of individuals and countries. As for guaranteeing the security of ultra-highly integrated chips, detecting slight abnormalities caused by malicious behavior in the current and voltage is challenging, as is achieving computability within a reasonable time and …


Use Of A Preliminary Artificial Intelligence-Based Laryngeal Cancer Screening Framework For Low-Resource Settings: Development And Validation Study, Shao Wei Sean Lam, Min Hun Lee, Michael Dorosan, Samuel Altonji, Hiang Khoon Tan, Walter T. Lee Aug 2025

Use Of A Preliminary Artificial Intelligence-Based Laryngeal Cancer Screening Framework For Low-Resource Settings: Development And Validation Study, Shao Wei Sean Lam, Min Hun Lee, Michael Dorosan, Samuel Altonji, Hiang Khoon Tan, Walter T. Lee

Research Collection School Of Computing and Information Systems

Background: Early-stage diagnosis of laryngeal cancer significantly improves patient survival and quality of life. However, the scarcity of specialists in low-resource settings hinders the timely review of flexible nasopharyngoscopy (FNS) videos, which are essential for accurate triage of at-risk patients.Objective: We introduce a preliminary AI-based screening framework to address this challenge for the triaging of at-risk patients in low-resource settings. This formative research addresses multiple challenges common in high-dimensional FNS videos: (1) selecting clear, informative images; (2) deriving regions within frames that show an anatomical landmark of interest; and (3) classifying patients into referral grades based on the FNS video …


Evaluating Immersion And Agency In Ai-Assisted Live Murder Mystery Games, Seraphina C. Courtney Aug 2025

Evaluating Immersion And Agency In Ai-Assisted Live Murder Mystery Games, Seraphina C. Courtney

LSU New Orleans Theses and Dissertations

This thesis explores the impact of AI-assisted narrative generation on player immersion and agency in a live-action roleplaying (LARP) experience. A live-action murder mystery game was designed and run in two formats: a static version with GPT-4 generated characters, dialogue, and stage directions, and a dynamic version where players created their own characters and improvised freely, guided by AI-generated narrative beats, a story element that moves the plot forward [21], that provided a narrative scaffolding for the players. The dynamic version employed a distributed computer vision system that tracks the movement of key items in the play-space so their relevance …


Artificial Intelligence On Campus: Revisiting Understanding As An Aim Of Higher Education, Jamie Herman, Henry Lara‐Steidel Aug 2025

Artificial Intelligence On Campus: Revisiting Understanding As An Aim Of Higher Education, Jamie Herman, Henry Lara‐Steidel

Prindle Faculty and Staff Publications

AbstractThe launch of the powerful generative AI tool ChatGPT in November 2022 sparked a wave of fear across higher education. The tool could seemingly be used to write essays and do other work without students putting in the effort expected of them. In this paper, Jamie Herman and Henry Lara‐Steidel posit a way of addressing the concerns over ChatGPT and increasingly powerful generative AI tools in the classroom by first examining what exactly, if anything, widespread AI use undermines in education. That question, they argue, is logically prior to the question of what to do or how best to embrace …


Considering The Concept Of Law In The Legal Singularity, Matthew Tse Aug 2025

Considering The Concept Of Law In The Legal Singularity, Matthew Tse

Canadian Journal of Law and Technology

This review article engages with the idea of a ‘‘legal singularity”, which has been developed by Abdi Aidid and Benjamin Alarie in their book, The Legal Singularity: How Artificial Intelligence Can Make Law Radically Better.

The legal singularity describes a legal system in the future that harnesses algorithmic computation to facilitate a ‘‘stable and complete legal order, capable of addressing and resolving practically all types of legal uncertainty in real time and on demand”. Aidid and Alarie believe algorithmic computation will achieve this promise in an interdependent dual process. On one hand, algorithms will structure the law with conceptual standardization. …


Advancing Fishery Dependent And Independent Habitat Assessments Using Automated Image Analysis: A Fisheries Management Agency Case Study, Scott Evans, Bronson Philippa, Carlo Mattone, Nick Konzewitsch, Renae Hovey, Marcus Sheaves, Gary A. Kendrick, Lynda M. Bellchambers Aug 2025

Advancing Fishery Dependent And Independent Habitat Assessments Using Automated Image Analysis: A Fisheries Management Agency Case Study, Scott Evans, Bronson Philippa, Carlo Mattone, Nick Konzewitsch, Renae Hovey, Marcus Sheaves, Gary A. Kendrick, Lynda M. Bellchambers

Fisheries Research Articles

Advances in artificial intelligence and machine learning have revolutionised data analysis, including in the field of marine and fisheries sciences. However, many fisheries agencies manage sensitive or proprietary data that cannot be shared externally, which can limit the adoption of externally hosted artificial intelligence platforms. In this study, we develop and evaluate two residual network-based automatic image annotation models to process fishery specific habitat data to support ecosystem-based fisheries management in the Exmouth Gulf Prawn Managed Fishery in Western Australia. Using an extensive dataset of 13,128 manually annotated benthic habitat images, we train a grid-based annotation model and an image-level …


Exploring Rehabilitation Therapists' Knowledge And Perspectives On The Use Of Artificial Intelligence And Machine Learning For Persons Poststroke, Hannah Clark, Mia Delvecchio, Min Hun Lee, Elena D. Brown, Kaia Mikula, Robert Halyama, Kasey Stepansky Aug 2025

Exploring Rehabilitation Therapists' Knowledge And Perspectives On The Use Of Artificial Intelligence And Machine Learning For Persons Poststroke, Hannah Clark, Mia Delvecchio, Min Hun Lee, Elena D. Brown, Kaia Mikula, Robert Halyama, Kasey Stepansky

Research Collection School Of Computing and Information Systems

Research Objectives: The use of technology such as robotics, gaming systems, self-monitoring apps, or other sensor-based devices in standard practice is infrequent. Due to the rapid development of artificial intelligence (AI) and machine learning (ML) applications, it is important to look at how therapists perceive AI/ML, and design applications with potential barriers in mind. to support future integration into practice. The purpose of this research project is to gain rehabilitation therapists’ perspectives on AI/ML in post-stroke assessment and intervention.Design: This ongoing study uses a mixed methods design with surveys and focus groups. Participants engaged in a 30-minute webinar to learn …


Ai-Enhanced Structured Literacy Intervention For Secondary Students: A Case Study Of Science Of Reading, Jennifer Bird Aug 2025

Ai-Enhanced Structured Literacy Intervention For Secondary Students: A Case Study Of Science Of Reading, Jennifer Bird

Teaching & Learning Faculty Publications

This study examines the effectiveness of Lexia PowerUp, an AI-powered literacy program, for sixth-grade students requiring Tier 3 reading intervention. Seven sixth-grade students (six boys, one girl; five African American, two Caucasian; all qualifying for free/reduced lunch) participated in a six-month intervention combining 50 minutes of daily small-group instruction with individualized Lexia PowerUp usage. Researchers measured progress through Achieve 3000 Lexile assessments and Lexia PowerUp performance data across three skill strands: Word Study, Grammar, and Comprehension. All participants demonstrated Lexile level improvements from beginning-of-year to mid-year assessments, though students remained below sixth-grade benchmarks (925-1070L). Analysis of Lexia PowerUp progression showed …


Design Of A Posit Based 6-Bit Configurable Cnn Hardware Accelerator For Audio And Image Classification, Steven Ng Aug 2025

Design Of A Posit Based 6-Bit Configurable Cnn Hardware Accelerator For Audio And Image Classification, Steven Ng

Theses

The rapid development and growing interest in Artificial Intelligence (AI) have resulted in a trend of models increasing in size and complexity at an accelerating rate. These larger models have demonstrated a greater ability to accomplish increasingly sophisticated tasks compared to smaller models, furthering the trend of making models larger. However, as the models continue to improve and grow larger, this has created a new challenge in deploying them into practical applications. Current models typically run inference on the same systems where they were trained. Large data centers comprising Central Processing Units (CPUs) and Graphics Processing Units (GPUs) are well-suited …


Non-Blackbox Robust Design Of Machine Learning In Networks, Venkat Sai Suman Lamba Karanam Aug 2025

Non-Blackbox Robust Design Of Machine Learning In Networks, Venkat Sai Suman Lamba Karanam

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Networked systems have become increasingly complex, with newer communication technologies and standards being added every day. Machine Learning (ML) and Artificial Intelligence (AI) paradigms have been adopted in networks to not only solve many fundamental problems, but also to allow seamless integration of components comprising them. The saying “let’s not reinvent the wheel” in ML/AI adoption implies that model architecture design be left for pure ML/AI researchers, while network researchers focus on input preprocessing (e.g. formatting the packet data to be fed to a model), hyperparameter fine-tuning and a trial-and-error approach to find the “best” result. …


Faced With Genai, Educators’ Engagement Capacity Matters More Than Ever, Thomas Menkhoff Aug 2025

Faced With Genai, Educators’ Engagement Capacity Matters More Than Ever, Thomas Menkhoff

Research Collection Lee Kong Chian School Of Business

In a commentary, SMU Professor of Organisational Behaviour & Human Resources (Education) Thomas Menkhoff stressed the need for educators to upskill so they can guide students in using generative artificial intelligence (GenAI) responsibly, rather than dismissing it. He argued that universities should move beyond prohibition and invest in AI literacy to safeguard academic integrity. Prof Menkhoff mentioned that combining the use of GenAI tools with effective prompting and Socratic questioning transforms students’ use of technology from passive consumption to active, reflective and critical engagement. To achieve this, he said that schools must set clear guidelines and design AI-compatible assessments that …


Roadside Asset Extraction From Mobile Lidar Point Cloud, Yushin Ahn, Riadh Munjy, Stephen Choi Aug 2025

Roadside Asset Extraction From Mobile Lidar Point Cloud, Yushin Ahn, Riadh Munjy, Stephen Choi

Mineta Transportation Institute

Mobile LiDAR systems are powerful tools that help us map roads and their surroundings in 3D with great speed and precision. The data provided by these systems support urban planning efforts, digital mapping, transportation infrastructure maintenance, and more. This report presents a comprehensive workflow for roadside asset extraction using Mobile Terrestrial Laser Scanning (MTLS) data, focusing on road lane detection, cross-section slope analysis, and point cloud classification. Roadside asset extraction is the identification and classification of roadside features like signs and poles. The dataset, acquired using a high-resolution mobile LiDAR system, contains over 5.7 billion points (pieces of data) across …


From Clones To Robots: Kazuo Ishiguro’S Non-Human Narrative And Itsethical Implications, Minrui Li Jul 2025

From Clones To Robots: Kazuo Ishiguro’S Non-Human Narrative And Itsethical Implications, Minrui Li

Kritika Kultura

feminist consciousness-raising, and taking liberty with genre and medium fluidity, this article


Reviving The Lost Art: Historical Foundations And Future Pathways For Bespoke Service In Luxury Retail, Andrew Burnstine Jul 2025

Reviving The Lost Art: Historical Foundations And Future Pathways For Bespoke Service In Luxury Retail, Andrew Burnstine

Faculty and Staff Publications & Presentations

The mid-20th century witnessed a zenith of deeply personalized, bespoke service within iconic luxury specialty retailers. This paper critically analyzes the foundational principles of this historical bespoke service model, extending Service-Dominant (S-D) Logic and retail evolution theory, to propose a robust framework for its modern revival. Employing a rigorous qualitative, multiple-case study approach, grounded in extensive historical and media analysis of four archetypal American and British luxury boutiques, and uniquely informed by an insider-ethnographic perspective on the central case exemplar ("Martha's"), the study distills six core principles: Profound Client Knowledge, Visionary Curation & Styling, Anticipatory & Proactive Service, The Exclusive …


Combination Of Irreversible Electroporation And Clostridium Novyi-Nt Bacterial Therapy For Colorectal Liver Metastasis, Zigeng Zhang, Guangbo Yu, Qiaoming Hou, Farideh Amirrad, Sha Webster, Surya M. Nauli, Jianhua Yu, Vahid Yaghmai, Aydin Eresen, Zhuoli Zhang Jul 2025

Combination Of Irreversible Electroporation And Clostridium Novyi-Nt Bacterial Therapy For Colorectal Liver Metastasis, Zigeng Zhang, Guangbo Yu, Qiaoming Hou, Farideh Amirrad, Sha Webster, Surya M. Nauli, Jianhua Yu, Vahid Yaghmai, Aydin Eresen, Zhuoli Zhang

Pharmacy Faculty Articles and Research

Colorectal liver metastasis (CRLM) poses a significant challenge in oncology due to its high incidence and poor prognosis in unresectable cases. Current treatments, including surgical resection, systemic chemotherapy, and liver-directed therapies, often fail to effectively target hypoxic tumor regions, which are inherently more resistant to these interventions. This review examines the potential of a novel therapeutic strategy combining irreversible electroporation (IRE) ablation and Clostridium novyi-nontoxic (C. novyi-NT) bacterial therapy. IRE is a non-thermal tumor ablation technique that uses high-voltage electric pulses to create permanent nanopores in cell membranes, leading to cell death while preserving surrounding structures, and …