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A Multimodal Intervention Treatment Plan For Adults With Generalized Anxiety Disorder In Primary Care, Morgan Cullings May 2023

A Multimodal Intervention Treatment Plan For Adults With Generalized Anxiety Disorder In Primary Care, Morgan Cullings

Evidence-Based Practice Project Reports

Generalized anxiety disorder (GAD) is a debilitating psychological condition that affects 3.1% of the American population and is one of the leading causes of disability (Anxiety and Depression Association of America, 2022; Baxter, 2014). The purpose of this evidence-based practice project was to implement a multimodal intervention to decrease GAD symptoms in adults in the primary care setting. The PICOT question that guided this project was: In adults, over the age of 18, who have been diagnosed with generalized anxiety disorder (GAD), does the combination of digital cognitive behavioral therapy (CBT) through a smartphone application, lifestyle modification education, and pharmacotherapy …


The Facilitative Role Of Workplace Anxiety In Increasing Motivation And Preparation Fueled By Self-Regulation, James Hayes May 2023

The Facilitative Role Of Workplace Anxiety In Increasing Motivation And Preparation Fueled By Self-Regulation, James Hayes

Student Works

As anxiety in the workplace continues to affect a substantial percentage of employees, an understanding of the facilitative aspects of anxiety may become increasingly relevant (American Psychological Association, 2009, as cited in Cheng & McCarthy, 2018). Anxiety in the workplace is generally disadvantageous, but significant evidence supports the idea that anxiety may benefit employees in various ways (Chandra et al., 2020). Notably, anxious feelings may spark increased motivation within employees, unlocking a greater focus on future goals (Spielberger, 1985, as cited in Cheng & McCarthy, 2018). In pursuit of these goals, anxious employees may find a greater capacity for self-regulation, …


Cbt Technology Implementation With Pediatric And Adolescent Populations, Tracey W. Kreipe, Heath Gage, Sandra Obiebi May 2023

Cbt Technology Implementation With Pediatric And Adolescent Populations, Tracey W. Kreipe, Heath Gage, Sandra Obiebi

Doctor of Nursing Practice Projects

Abstract

Digital therapy is a growing healthcare intervention improving limited access to specialty care for specific populations and geographic areas. Cognitive Behavioral Therapy (CBT) applications focus on treating anxiety and depression and assist pediatric and adolescent patients in learning behavioral techniques as they wait for 3-6 months or longer to see a mental health provider. Such delays are attributed to the national shortage of mental health practitioners and the further scarcity of fewer psychiatric providers in rural areas, causing the potential for adverse patient outcomes. The setting for this 8-week quality improvement project was a pediatric care clinic that sees …


Mind Over Matter: The Role Of Resilience, Crime Victimization, And Age At The Time Of Victimization On Psychological Health, Alana Compton May 2023

Mind Over Matter: The Role Of Resilience, Crime Victimization, And Age At The Time Of Victimization On Psychological Health, Alana Compton

Graduate Dissertations and Theses

The purpose of this study was to examine the relationship between crime victimization, age at the time of victimization, psychological health, and resilience. Past research has shown that crime victimization has been linked to higher levels of depression and suicidal ideation, anxiety, posttraumatic stress disorder (PTSD), and eating disorders, and that those who experience a traumatic event as a child are influenced more negatively than those who experience trauma as an adult. Additionally, resilience has been shown to mediate the influence that trauma has on an individual. Undergraduate students, graduate students, and faculty and staff were surveyed to determine their …


Mind Over Matter: The Role Of Resilience, Crime Victimization, And Age At The Time Of Victimization On Psychological Health, Alana Compton May 2023

Mind Over Matter: The Role Of Resilience, Crime Victimization, And Age At The Time Of Victimization On Psychological Health, Alana Compton

Graduate Dissertations and Theses

The purpose of this study was to examine the relationship between crime victimization, age at the time of victimization, psychological health, and resilience. Past research has shown that crime victimization has been linked to higher levels of depression and suicidal ideation, anxiety, posttraumatic stress disorder (PTSD), and eating disorders, and that those who experience a traumatic event as a child are influenced more negatively than those who experience trauma as an adult. Additionally, resilience has been shown to mediate the influence that trauma has on an individual. Undergraduate students, graduate students, and faculty and staff were surveyed to determine their …


Mind Over Matter: The Role Of Resilience, Crime Victimization, And Age At The Time Of Victimization On Psychological Health, Alana Compton May 2023

Mind Over Matter: The Role Of Resilience, Crime Victimization, And Age At The Time Of Victimization On Psychological Health, Alana Compton

Undergraduate Theses and Capstone Projects

The purpose of this study was to examine the relationship between crime victimization, age at the time of victimization, psychological health, and resilience. Past research has shown that crime victimization has been linked to higher levels of depression and suicidal ideation, anxiety, posttraumatic stress disorder (PTSD), and eating disorders, and that those who experience a traumatic event as a child are influenced more negatively than those who experience trauma as an adult. Additionally, resilience has been shown to mediate the influence that trauma has on an individual. Undergraduate students, graduate students, and faculty and staff were surveyed to determine their …


Psychometric Evaluation Of Phq–9 And Gad–7 Among Community Health Volunteers And Nurses/Midwives In Kenya Following A Nation-Wide Telephonic Survey, Sabina Odero, Paul Mwangi, Rachel Odhiambo, Brenda Nzioka, Constance Shumba, Eunice Ndirangu, Amina Abubakar May 2023

Psychometric Evaluation Of Phq–9 And Gad–7 Among Community Health Volunteers And Nurses/Midwives In Kenya Following A Nation-Wide Telephonic Survey, Sabina Odero, Paul Mwangi, Rachel Odhiambo, Brenda Nzioka, Constance Shumba, Eunice Ndirangu, Amina Abubakar

Institute for Human Development, East Africa

Background: Nurses/midwives and Community Health Volunteers (CHVs) are exposed to chronic stressors putting them at risk of developing mental health problems. This has been exacerbated by the COVID-19 pandemic. There is limited empirical evidence of the burden of mental health problems among health care workers partly due to the lack of adequately standardized and validated measures for use among health care workers in Sub-Saharan Africa. This study aimed to perform the psychometric evaluation of the PHQ-9 and GAD-7 administered to nurses/midwives and CHVs across 47 counties in Kenya.

Methods: Between June and November 2021, a national survey on mental well-being …


The Contribution Of Self-Compassion To Anxiety And Mood In Daily Life, Yamini Pant May 2023

The Contribution Of Self-Compassion To Anxiety And Mood In Daily Life, Yamini Pant

Honors Scholar Theses

Self-compassion, the act of being kind and understanding towards oneself, has been shown to have positive impacts on mental health. Depression and anxiety are both common mental health disorders that can interfere with an individual’s ability to function in daily life. Several studies have shown that self-compassion correlates with depression and anxiety at a cross-sectional level and across longer periods of time (e.g., several months). In the present study, we examined the fluctuations and the directionality of self-compassion, depression, and anxiety on a day-to-day basis over the span of a week. We also examined the ways that worry and rumination …


Understanding The Role Of Emotion Regulation Tendencies In The Momentary Associations Between Negative Affect And Eating Disorder Behaviors., Coby D. Banet May 2023

Understanding The Role Of Emotion Regulation Tendencies In The Momentary Associations Between Negative Affect And Eating Disorder Behaviors., Coby D. Banet

College of Arts & Sciences Senior Theses

Background: Eating disorders (EDs) are becoming increasingly commonplace and are associated with a broad array of dangerous medical complications. Further, EDs frequently present alongside comorbid psychiatric disorders (e.g., depressive and anxiety-related disorders), which are known to both predict ED severity and reduce treatment efficacy. While diagnostic categorization persists, Fairburn et al.’s (1993) transdiagnostic model suggests EDs may be more closely related and maintained through core, shared symptoms. To assess ED maintenance, momentary triggers such as negative affect (NA) are becoming increasingly centralized. The present study examines the roles of depressive symptoms and worry in predicting and moderating the relationships among …


The Mediation Of Mental Health Between Adverse Childhood Experiences And Risky Sexual Behavior, Kayla Marie Mandrigues, Julia Claire Dodd, Stacey Lynne Williams May 2023

The Mediation Of Mental Health Between Adverse Childhood Experiences And Risky Sexual Behavior, Kayla Marie Mandrigues, Julia Claire Dodd, Stacey Lynne Williams

Undergraduate Honors Theses

Risky sexual behaviors (RSB) have the potential to negatively impact individuals by increasing the risk of mental health issues, sexually transmitted infections (STIs), and unwanted pregnancies. Adverse childhood experiences (ACEs) and mental health disorders, such as anxiety, PTSD, and depression, have been known to increase RSB. The purpose of this study was to see if these mental health disorders mediate the relationship between ACEs and RSB. Participants (n = 342, mean age = 32) were recruited through social media to complete an online questionnaire. While history of ACEs significantly predicted engagement in RSB as well as all three of the …


Success Over Stress Support Group, Sophia Pescador-Torrance May 2023

Success Over Stress Support Group, Sophia Pescador-Torrance

Capstone Projects and Master's Theses

The Harden Wellness Center is located in Salinas, California on the campus of Harden Middle School. After surveying and interviewing eighth-grade students at Harden Middle School, it was determined that there was a need to provide healthy coping skills for stress and anxiety. The project provided students a place to learn healthy coping skills along with normalizing mental health services among adolescents. In order to engage students and keep them interested each week, focus on a new skill with an activity attached to reinforce the coping skill. By the end of the six weeks, the group started to talk about …


How Does Having A Pet During The Coronavirus-19 Pandemic Among University Students Affect Anxiety And Depression, Sugey Gonzalez-Escobedo, Jessica Morales Sanchez May 2023

How Does Having A Pet During The Coronavirus-19 Pandemic Among University Students Affect Anxiety And Depression, Sugey Gonzalez-Escobedo, Jessica Morales Sanchez

Electronic Theses, Projects, and Dissertations

This study examined whether having a pet among university and college students is associated with anxiety and depression during the Coronavirus-19 pandemic. A modified survey of a non-probability sample was conducted during a 5-month period during the Coronavirus-19 pandemic. A total of 115 students voluntarily participated and completed the survey. In the midst of the pandemic, students were forced to isolate themselves in their homes. This isolation may have caused anxiety and depression in students. However, a furry companion could have alleviated any anxiety/depression symptoms they may have endured during this time. This research contributes to the literature in regard …


The Impact Of Social Media Use On Social Isolation And Mental Health Among Young Adults, Mariana Romo May 2023

The Impact Of Social Media Use On Social Isolation And Mental Health Among Young Adults, Mariana Romo

Electronic Theses, Projects, and Dissertations

Social media use has become part of the everyday routines of society. It is very common to see people, especially young adults, be involved in more than one social media platform. It is also known that because of the features of social media less in-person interactions are required, which brings up the question of whether people feel more lonely or socially isolated with the increased use of social media platforms. Due to this increasing attachment to the use of social media and its possible relationship with social isolation and loneliness it is important to understand if there are any implications …


Covid-Induced Stress And Symptoms Of Anxiety And Depression In Undergraduate Students, Quenea Popoca, Christina Ngo May 2023

Covid-Induced Stress And Symptoms Of Anxiety And Depression In Undergraduate Students, Quenea Popoca, Christina Ngo

Electronic Theses, Projects, and Dissertations

The COVID-19 pandemic has had ramifications on the mental health of numerous vulnerable individuals. The aim of this study was to determine whether there is a relationship between COVID-19 induced stress and symptoms of anxiety and depression among undergraduate students. Embracing a quantitative design, this study surveyed 93 undergraduate students in major public universities in the western part of the United States (N = 93). Results from the nonparametric Mann-Whitney U Test revealed that there is no statistically significant relationship between COVID-19 induced stress and symptoms of anxiety and depression in undergraduate students (U = 734.500, p = .066 for …


Finding Their "Why": Examining The Development Of Sense Of Purpose During The University Years And Its Role In Student Well-Being, Michael Q. King May 2023

Finding Their "Why": Examining The Development Of Sense Of Purpose During The University Years And Its Role In Student Well-Being, Michael Q. King

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Nearly 20 million students were expected to be enrolled for college or university studies during the 2020-2021 academic year. These institutions often advertise to prospective students that, in addition to advancing their education, they will discover their purpose. Given previous work and current interest in sense of purpose, additional attention on sense of purpose in the university setting is worthwhile. In addition, as many university stakeholders are concerned about an ongoing mental health crisis, a further examination into a developmental construct (i.e. sense of purpose) thought to provide a “sheltering fortress in a world of constant threat” seems …


Graduation Anxiety, Britney Saguache May 2023

Graduation Anxiety, Britney Saguache

Capstone Projects and Master's Theses

Many graduating college students do not know how to manage their graduating anxiety and it can become a challenge to face. Anxiety during this time can cause students to feel worried leading up to graduation and have an impact on sleeping patterns, concentration in doing coursework and changes in relationships. This project is a workshop that includes ways to manage graduation anxiety and talks about fear of the future, relationship changes, dealing with expectations and the working world. When college students learn to manage graduation anxiety, it can help to overcome the unexpected, and bring back some control over the …


Prevention Of Mental Health Problems In K-8 Students, Kaylee Bays May 2023

Prevention Of Mental Health Problems In K-8 Students, Kaylee Bays

Capstone Projects and Master's Theses

This senior capstone research examines the methods being used to prevent mental health problems in K-8 students. Research from Chandra and Minkovitz (2007) shows that due to the lack of knowledge, confidence, and resources, teachers and on-site staff are not able to provide the necessary help to students who need mental health services. Through the use of literature review, interviews with three elementary teachers and three administrative staff, and 30 anonymous student surveys, the result findings indicate that the K-8 school in the Manteca Unified School District (MUSD) currently tackles student mental health issues primarily by onsite counselors and Social-Emotional …


Increasing Anxiety Awareness In High School Students, Kiley Arellano May 2023

Increasing Anxiety Awareness In High School Students, Kiley Arellano

Capstone Projects and Master's Theses

Many high school students may experience excessive anxiety. According to the National Institute of Health, nearly 1 in 3 of all adolescents ages 13 to 18 will experience an anxiety disorder. Persistent anxiety can lead to future health problems such as heart disease, respiratory disorders, and substance use disorders. If adolescents learn how to identify symptoms of anxiety and utilize effective coping mechanisms, they are likely to have positive academic outcomes, success in the workplace, and better quality of life. To address this, I have developed a one-day interactive lesson for junior and senior students at San Luis Obispo High …


High School Student Athletes: If Stress Is The Lock Is Communication The Key?, Danielle Carter May 2023

High School Student Athletes: If Stress Is The Lock Is Communication The Key?, Danielle Carter

Capstone Projects and Master's Theses

The focus of this Capstone Project was meant to analyze the possible issues high school student-athletes may face academically as well as mentally while in school. This issue is important to note because there is an increase in students participating in sports and the offered school support should reflect the growing population. An argument that was found was the possible overlook of the mental well-being of the student-athletes if they are academically succeeding or are accomplished athletes. The primary stakeholder's perspectives chosen were current high school student-athletes because they are able to provide insight into the current issues that student-athletes …


Influences Of Chronic Stress On Irritable Bowel Syndrome, Anxiety, Depression, And The Microbiome, Julia A. Semaan May 2023

Influences Of Chronic Stress On Irritable Bowel Syndrome, Anxiety, Depression, And The Microbiome, Julia A. Semaan

Masters Theses

IBS effects approximately 5% of the world’s population with symptoms ranging from unexplainable constipation to daily abdominal pain. Though treatment options are available and have been proven beneficial for certain individuals, discovering the root cause of IBS has been difficult to accomplish due to the variety of symptoms that differ from case to case. This study aims to increase understanding of the influence that chronic stress has on irritable bowel syndrome, anxiety, depression, and the microbiome in the college-age population since this group is likely to experience daily stressors, anxiety- and depressive-like thoughts, as well as IBS symptoms. Current research …


Leveraging Simulation To Understand Nursing Student Learning In Technologically Complex Environment, Deborah Rojas May 2023

Leveraging Simulation To Understand Nursing Student Learning In Technologically Complex Environment, Deborah Rojas

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction The adoption of simulation technologies in schools of nursing has increased significantly over the last 5 years. Results regarding the use of simulation technology have been positive. The use of simulation technologies has been developed to include complex nursing situations that resemble real clinical settings. Research has demonstrated that memory recall is better in an environment that is the same or similar to the environment in which the learning took place (Krokos et al., 2018). For this reason, educators have used simulation technologies to create realistic environments where students can learn. However, learning outcomes in simulations are affected by …


Pilot Study: The Effect Of Individual Versus Group Animal-Assisted Therapy On Undergraduate Student Anxiety, Jessica Hanson, Hannah Tucker May 2023

Pilot Study: The Effect Of Individual Versus Group Animal-Assisted Therapy On Undergraduate Student Anxiety, Jessica Hanson, Hannah Tucker

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Purpose: The purpose of this study was to evaluate the relationship of Animal-Assisted Therapy (AAT) on undergraduate student test anxiety; comparing an individual AAT session to a group AAT session. AAT may be a solution for decreasing anxiety for undergraduate students. The study adds empirical knowledge to the field of AAT and student anxiety coping methods. The study question was: What is the effect of one-on-one and group Animal-Assisted Therapy sessions on undergraduate student anxiety?

Methods: This study used a convenience sample randomly assigned to either a group of 3 to 5 students (n=9) or an individual AAT session (n=10) …


Sleep Quality In Undergraduate Students: Examining The Role Of Class Rank And Related Individual Differences, Lauren Yocum, Lauren Yocum May 2023

Sleep Quality In Undergraduate Students: Examining The Role Of Class Rank And Related Individual Differences, Lauren Yocum, Lauren Yocum

Honors College Theses

College students are likely to experience stress due to increased responsibilities, more demanding coursework, and maintaining a balance between academics and social life. Indeed, college students are at risk for experiencing clinically-significant depressive and anxiety symptoms, as well as sleep disturbances, likely as a result of these challenges. Although the relationship between these affective variables and college stressors are well-documented, less attention has been given to the factors that may help promote better sleep, with the majority of research documenting the intrinsic bidirectional nature of mood and sleep (e.g., lack of sleep leads to worse mood which further exacerbates sleep …


American Women’S Experiences With Intimate Partner Violence During The Start Of The Covid-19 Pandemic: Risk Factors And Mental Health Implications, Debra L. Oswald, Astrida S. Kaugars, Mary Tait May 2023

American Women’S Experiences With Intimate Partner Violence During The Start Of The Covid-19 Pandemic: Risk Factors And Mental Health Implications, Debra L. Oswald, Astrida S. Kaugars, Mary Tait

Psychology Faculty Research and Publications

In an online survey, women self-reported high prevalence of intimate partner violence during the early days of the pandemic. Risk factors for experiencing intimate partner violence (IPV) included having a child under the age of 18, being a sexual minority, living in a rural community, and stressors related to healthcare access, income/employment stress, and COVID-19 exposure or illness. Women who worked during the pandemic and were older were less likely to experience IPV. Women who reported IPV also reported increased anxiety and depression. The results are discussed in terms of clinical and policy implications for supporting women who are victims …


Effects Of The True Crime Genre On Anxiety, Armani Lacour, Theresa A. Moore Apr 2023

Effects Of The True Crime Genre On Anxiety, Armani Lacour, Theresa A. Moore

Undergraduate Research Symposium

Within the literature, violent media is well-established to induce acute and chronic anxiety; violent media is often utilized in experimental research to induce anxiety. Because a relationship between violent media and anxiety has been established, it is plausible exposure to true crime media may also induce anxiety.

The true crime genre features criminal cases of a violent nature, often communicated through visual or auditory media (e.g., television or podcasts, respectively). Within the literature, true crime is an exploratory area of research, thus, additional research is required to determine whether exposure to true crime increases anxiety. The present study will add …


Negative Emotions In Adults With Congenital Heart Disease, Haley Alberson, Kamila White, Philip Ludbrook, Ari Cedars Apr 2023

Negative Emotions In Adults With Congenital Heart Disease, Haley Alberson, Kamila White, Philip Ludbrook, Ari Cedars

Undergraduate Research Symposium

Pain may signal a life-threatening heart problem, particularly for a person with living with congenital heart disease (CHD). Aims of the current study were to describe pain and its distribution, and to test a theoretical framework for poor outcomes including the independent and combined impact of medical and psychological risk among 106 outpatients (46% female) with CHD. Our sample represented a wide-range of pain experiences, and included both tails of the distribution (i.e., quartiles), SF-36 Pain Scale IQR = 32.5, R 22.5–100. About one-third reported persistent, at least moderately intense pain interfering with daily life. Univariate tests showed poorer pain …


Anxiety Of Parents Of Children With Intellectual Disabilities About School Services, S. Aldehami Apr 2023

Anxiety Of Parents Of Children With Intellectual Disabilities About School Services, S. Aldehami

Information Sciences Letters

This online survey study investigated 98 Saudi Arabian parents’ levels of anxiety about school services for their children with intellectual disabilities according to two anxiety subscales: environment and communication, as per demographic variables. The findings demonstrate that there are no statistically considerable distinctions in parental anxiousness about the school setting or information exchange based on gender, and there are also no statistically meaningful distinctions in parental anxiousness about the school setting based on parental degree of education. Nonetheless, parents with a bachelors degree or more report far less worry than those with a high school diploma or less. Also, the …


Analysis Of Psychological Symptoms Resulting From The Covid-19 Pandemic, R. M. Abdelrahman, A. F. Alsharif, N. R. Alsalhi Apr 2023

Analysis Of Psychological Symptoms Resulting From The Covid-19 Pandemic, R. M. Abdelrahman, A. F. Alsharif, N. R. Alsalhi

Information Sciences Letters

The present study aimed to investigate the level of severity of some psychological symptoms resulting from the Coronavirus pandemic, among a sample of Ajman University students in the United Arab Emirates, and to verify the differences between students’ demographic variables. The study used the descriptive-analytical approach and a modified DASS-21 scale, by adding the two scales of phobia and mental distraction to the tool. The reliability of the tool was verified for use on the sample in the current study. The most prominent results indicated that the highest psychological symptoms resulting from the Coronavirus pandemic were phobia (1.53 ± 0.98) …


Mental Health And Academic Experiences Among U.S. College Students During The Covid-19 Pandemic, Michael E. Roberts, Jillian Meyer '23, Elizabeth A. Bell Apr 2023

Mental Health And Academic Experiences Among U.S. College Students During The Covid-19 Pandemic, Michael E. Roberts, Jillian Meyer '23, Elizabeth A. Bell

Psychology and Neuroscience Faculty Publications

When the COVID-19 pandemic began, U.S. college students reported increased anxiety and depression. This study examines mental health among U.S college students during the subsequent 2020–2021 academic year by surveying students at the end of the fall 2020 and the spring 2021 semesters. Our data provide cross-sectional snapshots and longitudinal changes. Both surveys included the PSS, GAD-7, PHQ-8, questions about students’ academic experiences and sense of belonging in online, in-person, and hybrid classes, and additional questions regarding behaviors, living circumstances, and demographics. The spring 2021 study included a larger, stratified sample of eight demographic groups, and we added scales to …


Telehealth-Based Music Therapy Versus Cognitive Behavioral Therapy For Anxiety In Cancer Survivors: Rationale And Protocol For A Comparative Effectiveness Trial, Kevin T Liou, Kelly M Mcconnell, M Beatriz Currier, Raymond E Baser, Jodi Macleod, Desiree Walker, Camila Casaw, Greta Wong, Lauren Piulson, Karen Popkin, Anamaria Lopez, Katherine Panageas, Joke Bradt, Jun J Mao Apr 2023

Telehealth-Based Music Therapy Versus Cognitive Behavioral Therapy For Anxiety In Cancer Survivors: Rationale And Protocol For A Comparative Effectiveness Trial, Kevin T Liou, Kelly M Mcconnell, M Beatriz Currier, Raymond E Baser, Jodi Macleod, Desiree Walker, Camila Casaw, Greta Wong, Lauren Piulson, Karen Popkin, Anamaria Lopez, Katherine Panageas, Joke Bradt, Jun J Mao

Department of Medical Oncology Faculty Papers

Background: Cancer survivors represent one of the fastest growing populations in the United States. Unfortunately, nearly 1 in 3 survivors experience anxiety symptoms as a long-term consequence of cancer and its treatment. Characterized by restlessness, muscle tension, and worry, anxiety worsens the quality of life; impairs daily functioning; and is associated with poor sleep, depressed mood, and fatigue. Although pharmacological treatment options are available, polypharmacy has become a growing concern for cancer survivors. Music therapy (MT) and cognitive behavioral therapy (CBT) are evidence-based, nonpharmacological treatments that have demonstrated effectiveness in treating anxiety symptoms in cancer populations and can be adapted …