Digital Commons Network^™

Group Therapy Proposal: Cognitive-Behavioral Therapy (Cbt) Group For Anxiety And Depression Management, Maddy Buss

Distinguished Student Scholarship Collection

This group therapy proposal outlines an eight-week Cognitive-Behavioral Therapy (CBT) program designed for adults experiencing anxiety and depression. The group aims to provide a structured, evidence-based environment where participants develop coping skills, enhance emotional regulation, and improve interpersonal effectiveness through CBT interventions. Sessions focus on cognitive restructuring, behavioral activation, and mindfulness, with progress monitored via validated assessment tools and participant feedback. The plan emphasizes peer support, skill-building, and resilience within a safe group setting. [Abstract generated by AI.]

Anxiety And Depression In Today's Youth: A Current Look Into Assessment And Treatment., Meredith J. Scafe, Meghan Kanya, Meaghan Flynn, Ram Chettiar

Manuscripts, Articles, Book Chapters and Other Papers

Following the COVID-19 pandemic, the American Academy of Pediatrics (AAP), the American Academy of Child and Adolescent Psychiatry, and the Children's Hospital Association declared a national emergency in child and adolescent mental health. Rates of anxiety and depression in youth continue at unprecedented levels, contributing to rising numbers of suicide attempts and lowered school attendance. Though many medical providers are trained to assess and provide recommendations for anxiety and depression, many report feeling ill-equipped to address these concerns in a timely, feasible, and effective manner. We review the existing literature on screening for anxiety and depression in the medical setting …

Migration And Separation Among Latinx Asylum Seekers: Experiences And Relations With Anxiety And Depression, Amanda Venta, Ashley Bautista, Maria Cuervo, Alfonso Mercado, Luz M. Garcini, Cecilia Colunga-Rodríguez, Mario Angel-Gonzalez

Psychological Science Faculty Publications

This study sought to describe the experiences of families seeking asylum at the U.S./Mexico border and explore how traveling with and without family was associated with mental health in a large group of Latinx adults. Additionally, we explored relations between experiences of family separation due to migration and anxiety and depression. N = 400 participants were recruited from two main locations: an encampment site along the Rio Grande River in Reynosa Tamaulipas, Mexico and a respite center serving families recently released by U.S. Customs and Border Protection in McAllen, Texas. The average age of participants was 31.35 years (SD …

Gender Differences In The Associations Between Developmental Disabilities And Anxiety And Depression Symptoms Among U.S. Children: Insights From The 2021 National Health Interview Survey, Gloria Wang, Muyiwa Ategbole, Xingguang Luo, Kesheng Wang, Chun Xu

Health & Biomedical Sciences Faculty Publications

Background: Limited research has explored the associations between developmental disabilities and symptoms of anxiety and depression among U.S. children during the COVID-19 pandemic.

Objective: This study investigates the associations between developmental disabilities and symptoms of anxiety and depression among U.S. children and examines whether these associations differ by gender.

Methods: The analysis included 6092 children aged 5-17 from the 2021 National Health Interview Survey (NHIS). Key risk factors for anxiety and depression symptoms included attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), intellectual disability (ID), learning disability (LD), and developmental delay (DD). Weighted multivariable logistic regression (MLR) was conducted to evaluate …

Exercise Effects On Symptoms Of Depression And Anxiety Vary By Patient, Clinical, And Intervention Characteristics In Cancer Survivors: Results From Pooled Analyses Of Individual Participant Data Of 26 Rcts, Marlou Floor Kenkhuis, Meike Doorenbos, Isa H. Mast, Neil K. Aaronson, Marc Van Beurden, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvão, Martine M. Goedendorp, Wim H. Van Harten, Sandi C. Hayes, Anouk E. Hiensch, Melinda L. Irwin, Marie José Kersten, Hans Knoop, Anne M. May, Alex Mcconnachie, Willem Van Mechelen, Nanette Mutrie, Robert U. Newton, Frans Nollet, Hester S. Oldenburg, Martina E. Schmidt, Kathryn H. Schmitz, Karl Heinz Schulz, Dennis R. Taaffe

Research outputs 2022 to 2026

Purpose: This study aimed to investigate whether socio-demographic, clinical, and intervention-related variables moderate the effects of exercise on depression and anxiety symptoms in cancer survivors. Methods: Data from 26 RCTs in the POLARIS database were analyzed using a one-step individual participant data (IPD) meta-analytic approach with linear mixed models to assess exercise effects on depression and anxiety symptoms (z-scores). Interaction terms were added to these models to explore moderators. Results are presented as betas (corresponding to Cohen’s d effect size). Results: Albeit statistically significant, exercise demonstrated negligible effects on symptoms of depression (β = − 0.11; 95% CI = − …

Evaluating The Predictive Value Of Basc-3 Anxiety Scale And Working Memory Index Scores For Clinically Significant Test Anxiety: A Comprehensive Analysis Of Non-Classifiable Cases, Des'tiana S. Williams

Electronic Theses and Dissertations

This dissertation will explore how test anxiety (TA) affects working memory (WM) and whether certain factors can help predict higher levels of test anxiety. Anxiety has been defined as a common experience that can show up in various forms—like general worry, social fears, panic attacks, and specific phobias (APA, 2022). It was described as often triggering our natural “fight-or-flight” response, which can impact our ability to focus, think clearly, and remember things. For students, test anxiety has been especially challenging, affecting how they perform in high-stakes academic settings. Using data from a university based psychological assessment center, this study will …

Evaluating The Predictive Value Of Basc-3 Anxiety Scale And Working Memory Index Scores For Clinically Significant Test Anxiety: A Comprehensive Analysis Of Non-Classifiable Cases, Des'tiana S. Williams

Electronic Theses and Dissertations

This dissertation will explore how test anxiety (TA) affects working memory (WM) and whether certain factors can help predict higher levels of test anxiety. Anxiety has been defined as a common experience that can show up in various forms—like general worry, social fears, panic attacks, and specific phobias (APA, 2022). It was described as often triggering our natural “fight-or-flight” response, which can impact our ability to focus, think clearly, and remember things. For students, test anxiety has been especially challenging, affecting how they perform in high-stakes academic settings. Using data from a university based psychological assessment center, this study will …

Mechanisms Of Change In Exposure Therapy For Anxiety And Related Disorders: A Research Agenda, Kristen Benito, Andre Pittig, Jonathan Abramowitz, Joanna J Arch, Denise Chavira, Rianne De Kleine, Alessandro S De Nadai, Dirk Hermans, Stefan G Hofmann, Jürgen Hoyer, Jonathan D Huppert, Katharina Kircanski, Peter M Mcevoy, Heidi Meyer, Marie-H Monfils, Santiago Papini, Winfried Rief, David Rosenfield, Eric A Storch, Michael J Telch, Michael W Otto, Jasper A J Smits

Faculty, Staff and Students Publications

Anxiety and related disorders are a significant public health burden with rising prevalence in the wake of the COVID-19 pandemic. As demand for effective anxiety treatment increases, so too does the need for strategies to bolster treatment outcomes. Research on the mechanisms of exposure therapy, the frontline behavioral treatment, will be critically important for optimizing clinical outcomes. We outline an initial agenda for future research on the mechanisms of change of exposure therapy, developed in collaboration with a large international team of researchers through the Exposure Therapy Consortium (ETC). Key questions and recommendations for future research focus on five priority …

Diagnostic Accuracy Of Screening Tools For Depression And Anxiety In Cervical Dystonia, Davide Martino, Mehrafarin Ramezani, Steven Bellows, Brian D Berman, Florence Ching-Fen Chang, Jeanne Feuerstein, Victor Fung, Gamze Kilic Berkmen, Irene A Malaty, Claire Maciver, Scott A Norris, Kathryn J Peall, Joel S Perlmutter, Sarah Pirio Richardson, Laura J Wright, Zahra Goodarzi, Hyder A Jinnah

Faculty, Staff and Students Publications

Introduction: Despite their high prevalence and impact, depression and anxiety are not routinely screened for, and accuracy of screening procedures is unknown in adult-onset dystonia. We evaluated accuracy parameters of selected self-rated scales for depression and anxiety in patients with idiopathic cervical dystonia (CD).

Methods: Two-hundred-and-ten patients with idiopathic CD were recruited from 10 movement disorders centers from the US, Canada, Australia, and UK. At the end of each botulinum toxin cycle, participants were administered the Adult Standard Mini-International Neuropsychiatric Interview (MINI) as reference standard for depression and anxiety. Participants completed 8 self-administered index instruments (2 for depression, 2 for …

Effectiveness Of Music Therapy On Anxiety Among Antenatal Mothers With Pregnancy-Induced Hypertension, Jyoti, Molly Babu, Sarita Shokanda, Shatrughan Pareek

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Every pregnancy is special and each and every pregnant woman must receive special care. It was estimated, by the WHO that deaths due to hypertensive disorders of pregnancy represented 13% of all maternal deaths. The study was conducted with an aim to assess the effect of music therapy on anxiety among antenatal mothers with pregnancy-induced hypertension (PIH).

MATERIALS AND METHODS:

A true experimental research approach with Pretest posttest control group design was adopted for the study. Simple random sampling technique was applied to select 60 participants (30 experimental and 30 controls) but assignment of participants to the respective group …

Academic Loss-Related Anxiety Among College Students During Covid-19 Pandemic, Sagar Rai, Zareen Akhtar, Kaushal Kishor Singh, Madan Lal Brahma Bhatt, Sudhir Kumar Verma, Sujita Kumar Kar

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

The global outbreak of SARS-CoV2, initially affecting few individuals in Wuhan city of China, is now devastating millions of lives. Among all, students face substantial challenges, mainly in academic losses due to the imposed lockdown that may be detrimental to their mental well-being. Our study aimed to identify the anxiety levels among university students undergoing training in various disciplines.

METHODS:

It was a cross-sectional study. General Anxiety Disorder-7 scale within a semi-structured questionnaire was used to assess students' anxiety levels about their academic loss.

RESULTS:

A total of 507 students from India participated in the survey. Eventually, the prevalence …

Correlation Between Physical Abuse And Anxiety Among School-Going Adolescents (10-16 Years Age) Of Belagavi A School-Based Study, Gavishiddhayya B. Salimath, Sudha A. Raddi

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

The relationship between childhood maltreatment and bountiful range of mental divergence has been well assumed. Anxiety disorders are the usual mental health concern facing adolescents today, yet they are largely insufficiently treated. Physical abuse often does not occur in isolation, but as part of a constellation of behaviors including authoritarian control, anxiety-provoking behavior, and a lack of parental warmth.

Objectives:

To find out the correlation between physical abuse and anxiety among school-going adolescents.

Materials and Methods:

The present study was conducted among eight schools at Belagavi, using descriptive cross-sectional research design with stratified cluster sampling. It included primary and …

“Comparative Evaluation Of Intranasal Dexmedetomidine And Intranasal Midazolam For Premedication In Children Undergoing Anesthesia” A 1-Year Double-Blind Randomized Controlled Trial, Narendra Malineni, Manjunath C. Patil

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Children undergoing surgical procedures can experience significant anxiety and distress during perioperative period. Use of sedative premedication helps to reduce anxiety and facilitate a smooth induction of anesthesia. Midazolam is the most commonly used premedication agent with adverse effects such as behavioral changes, hiccups, and paradoxical hyperactive reactions. Dexmedetomidine, a highly selective α-2 agonist, has sedative properties.

Aims and Objectives:

The aim and objective of this study was to compare the efficacy of intranasal dexmedetomidine and intranasal midazolam for premedication in pediatric age group for parental separation anxiety and acceptance of anesthesia mask.

Materials and Methods:

This study included …

Investigating The Relationship Between Social Media Usage, Perceived Stress, Depression And Spirituality, Jeffrey Leyland King

Doctoral Dissertations and Projects

The rapid rise in social media usage (SMU) in the past two decades correlates with a sharp rise in depression (Dep) and self-harm in emerging adults. Many studies have focused on the aspects of diminished well-being, self-harm and suicide, and a possible association between daily spiritual experiences (DSE) and Dep, although there is a paucity of research on DSE to moderate the association. This study was guided by three theories; need-to-belong, social comparison, and cognitive dissonance. The present quantitative study aimed to explore the significance of the association between SMU, perceived stress (PS), and Dep moderated by DSE in emerging …

Why Gen Z Is More Anxious Than Ever? Turning To Social Chats For Answers, Yi Luo, Jin-A Choi, Bond Benton

College of Communication and Media Scholarship and Creative Works

As social media has evolved into a prominent part of Gen Z’s social interaction, this study attempted to enrich our current understanding of Gen Z’s mental health struggles through their conversations surrounding anxiety on social media. Highlights of the findings included the following. First, the overwhelming presence of fear (83%) illustrates that anxiety is an emotionally draining experience for many Gen Z users. The use of emotionally charged language to publicly share their struggles with anxiety reflect increasing self-awareness and a cultural shift toward normalizing mental health conversations. Second, the open, candid conversations on anxiety indicate that anxiety is experienced …

Relation Between Executive Functions, Ruminative Thinking Style, And Internalizing Symptoms In Neurodivergent Individuals., John Strom

Clinical Psychology Dissertations

Introduction: Neurodevelopmental disorders (NDD) are among the most common psychological disorders occurring in childhood (Bishop, 2010; Scandurra et al., 2019), and are commonly associated with a host of psychological challenges including deficits in executive functioning (Craig et al., 2016; Demetriou et al., 2019) as well as comorbid internalizing disorders such as depression and anxiety (Katzman et al., 2017; Kirsch et al., 2020; Simonoff et al., 2008). Research has suggested that executive function deficits may contribute to symptoms of depression and anxiety and that this relation may be mediated by ruminative thinking styles (Snyder et al., 2019; von Hippel et al., …

Impact Of Perceived Stress And Trait Resilience On Mental Health Outcomes Related To Traumatic Stress Exposure, Ken Safley

Clinical Psychology Dissertations

Traumatic stress exposure is common and associated with a range of adverse psychological outcomes, including anxiety, depression, and posttraumatic stress disorder (PTSD). These effects are cumulative, with increased exposure linked to greater psychological distress. However, there is considerable variability in how individuals respond to trauma, suggesting the influence of cognitive and dispositional factors. Cognitive models of PTSD highlight the role of stressor appraisals in the development of psychopathology, while individual differences in protective factors, such as trait resilience, may buffer these effects. The present study investigated whether perceived stress mediates the relationship between trauma exposure and psychological outcomes, and whether …

Effectiveness Of Digital Behavioral Activation Interventions For Depression And Anxiety: Systematic Review And Meta-Analysis, Eric Jia, Jushawn Macon, Michelle Doering, Joanna Abraham

2020-Current year OA Pubs

BACKGROUND: As digital interventions gain prominence in mental health care, they present opportunities to improve access and scalability. Despite their potential, the overall impact of digital behavioral activation (BA) interventions across different formats and populations is not yet fully understood.

OBJECTIVE: This systematic review examines the characteristics and functions of digital BA interventions and evaluates their effectiveness for mental health and other patient-related outcomes.

METHODS: A comprehensive search of databases (PubMed, Embase, Web of Science, APA PsycInfo, and ClinicalTrials.gov) was performed in November 2023 to identify randomized controlled trials (RCTs) assessing the effectiveness of digital BA interventions for depression and …

Examining The Anxiolytic Effects Of Flavonoids In Passionflower: A Gut-Brain Axis Perspective, Khelen R. Walsh

PSU McNair Scholars Online Journal

This literature review investigates the influence of Passiflora incarnata on the Gut-Brain Axis, focusing on the role of flavonoids and the specific biological mechanisms involved in this process. The study aims to identify Passiflora incarnata as a practical, non-harmful, and cost-effective alternative to current modern anxiety medications. This study also emphasizes the need for further clinical trials to integrate Passiflora incarnata further into healthcare settings. Using a narrative review approach, this analysis will examine pre-existing empirical articles, all of which have been found on credible sites, are peer-reviewed, and have been published within the past twenty-five years. The data discussed …

Electro Transcranial Magnetic Stimulation (Etms) Effects On Pharmacoresistent Sleep Disorders Using A Quantitative Electroencephalogram (Qeeg), Sarah Diane Dean

Doctoral Dissertations and Projects

The following quantitative correlational study investigated the effects of eTMS on individuals with pharmacoresistant sleep disorders using a qEEG. This research measures the dimensions of anxiety, depression and quality of life (QoL) as it relates to untreated secondary diagnosis. Additionally, this research examines the activity level of the dorsolateral prefrontal cortex in relation to eTMS treatments. It was found that correlation with anxiety (rs = -.466, p < .001), depression (rs = -0.556, p < 0.001), quality of life (rs = -.436, p < .001), and sleep disturbances (rs = -0.452, p < 0.001), have a statistically significant negative correlation with dlPFC activity level. Finally, it was found that eTMS does have a statistically significant relationship with sleep disturbances as well as anxiety, depression and general quality of life (U (195) = 4647, p = .971). This is important to the field of neuroscience as it provided a more precise form of individualized neuromodulation through the use of a uncommon type of transcranial magnetic stimulation.

Factors Predicting Health-Related Quality Of Life Among People With Epilepsy, Thanin Rounratana, Noppawan Phinitkhajorndech, Nipaporn Butsing

Journal of Health Research

Background: Epilepsy is a chronic neurological disease that has a significant influence on individuals' daily activities and health-related quality of life (HRQoL). The HRQoL among people with epilepsy varies depending on several factors. This study aimed to investigate the HRQoL of people with epilepsy and its predicting factors.

Methods: A convenience sampling method was applied to enroll 157 participants with epilepsy who were treated with medication at a tertiary hospital in Bangkok, Thailand, from August 2023 to January 2024. The questionnaires included general characteristics, comorbidities, generalized anxiety disorder (GAD), the International Physical Activity Questionnaire (IPAQ) short form, the Pittsburgh …

Gi, Pain, Anxiety, And Mood Symptoms Among Youth With Fapds, Helen Bedree

College of Science and Health Theses and Dissertations

Pediatric functional abdominal pain disorders (FAPDs) frequently persist into adulthood, thus developmental considerations are critical for monitoring symptom presentation and tailoring treatments. In addition to core symptoms, such as pain and gastrointestinal symptoms, mood and anxiety symptoms often co-occur as well as negative impacts on functioning and quality of life. The current study took a developmental approach to assess core pain, gastrointestinal, anxiety, and mood symptoms among youth with FAPDs (N = 105), as well as agreement across youth and their caregivers on these key symptoms. Developmental stages included early childhood, middle childhood, adolescence, and emerging adulthood. A cluster …

Understanding And Addressing Mental Health Challenges Of Families Admitted To The Neonatal Intensive Care Unit., Ashley D. Osborne, Daphna Yasova Barbeau, Tiffany Gladdis, Kara Hansen, Tonia Branche, Emily R. Miller, Christine C. Pazandak, Margaret K. Hoge, Michelle Spencer, Diana Montoya-Williams, Ryan Barbeau, Heather Padratzik, Stephen Lassen

Manuscripts, Articles, Book Chapters and Other Papers

This article reviews the psychological distress experienced by NICU families, including anxiety, postpartum depression (PPD), and post-traumatic stress disorder (PTSD), in addition to providing recommendations for clinicians at the individual, institutional, and national level. Currently, mental health screenings, specialized evaluations, and treatment options are not routinely offered to NICU families and are frequently under-utilized when offered. Here we provide expert opinion recommendations to address challenges in supporting universal screening, offering bedside interventions, including trained mental health professionals in care plans, updating neonatology training competencies, and advocating for policies that support the mental health of NICU families. We advocate that mental …

Factors Influencing Medical University Students' Emotions And Infection Prevention Behaviors Amid The Spread Of Covid-19: Analysis From A Social Network Perspective, Jian-Jhou Chen, Peih-Ying Lu

Journal of Medical Education

Background: By adopting a social network perspective, we estimated the impact of the extent of information dissemination and exchange on the emotions and behaviors of medical university students during the COVID-19 epidemic. Methods: Students from a medical university in southern Taiwan were selected through stratified sampling. From October 5 to October 11, 2020, a survey was conducted using a self-developed COVID-19 Response Assessment Scale. A total of 1,162 valid responses were collected. Results: Higher frequencies of information acquisition from social networks or news media and information exchange with others in social networks were associated with higher levels of worries regarding …

Extending The Psychometric Properties Of The Arabic Rcmas In Jordanian Children Aged 7–16: Considering Gender And Age Invariances, Mohammad A. Al Jabery, Ebenezer Afrifa-Yamoah, Sara Farid Khalaf, Diana H. Arabiat

Research outputs 2022 to 2026

Background: There are diverse gender and age-based differences in levels of anxiety between boys and girls. Establishing the validity of such assessments entails inquiry on the construct validity and measurement invariance of tools. This study examined the psychometric properties of the Arabic version of the Revised Children's Manifest Anxiety Scale (RCMAS) to assess its suitability for measuring child anxiety and its equivalence across genders and ages. Methods: A cross-sectional design was employed to examine the generalizability of the measure's structure. The study was conducted between November 2021 and January 2022. A sample of 178 children (86 boys and 92 girls), …

Alterations In Gut Microbiome Composition And Increased Inflammatory Markers In Post-Covid-19 Individuals, Tatiana Barichello, Bruno Kluwe-Schiavon, Laura A Borba, Lucas C Pedro, Flávia S Niero, Laísa N Dos Santos, Letícia M Leonardo, Zuleide M Ignácio, Rodrigo Morales, Luciane B Ceretta, Gislaine Z Reus

Faculty, Staff and Student Publications

Dysfunctions in the immune system and alterations in the microbiome composition following SARS-CoV-2 infection contribute to persistent neurological issues observed in long COVID-19 survivors. We hypothesize that alterations in the gut microbiome composition and peripheral inflammatory profile following COVID-19 may play pivotal roles in behavior changes among individuals experiencing long-term illness. This cross-sectional study included a sample of post-COVID-19 and non-COVID-19 subjects. We assessed the presence of psychiatric conditions utilizing standardized diagnostic criteria, Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression (HAM-D), Biological Rhythms in Neuropsychiatry Assessment Interview (BRIAN), and Functional Assessment Short Test (FAST). Plasma samples …

Predictors Of Nursing Students' Stress, Anxiety, And Depression During The Covid-19 Pandemic In A Hispanic-Serving University In South Texas: A Cross-Sectional Study, Maria I. Diaz, Eleftherios Gkioulekas, Nancy Nadeau

School of Mathematical & Statistical Sciences Faculty Publications

Background: In nursing education, there have been several studies on the impact of the COVID-19 pandemic on the ability of nursing students to cope while in nursing school.

Purpose statement: The goal of this study is to assess undergraduate nursing students' support mechanisms as predictors of stress, anxiety, and depression during the COVID-19 pandemic within a Hispanic-serving institution in South Texas.

Methods: Across-sectional design was used in this study. An online survey using self-reported questionnaires was used to gather data from an undergraduate nursing student cohort during the Fall 2021 semester. Linear regression was used to identify the predictors of …

Social Media, Religion, And Anxiety: Comparison Of Age Groups, Kaye Eileen Redeker

Doctoral Dissertations and Projects

Social media has become an integral part of daily life for all age groups. The current research is mixed, showing both positive and negative effects from social media on mental health. This study aimed to examine how the duration of social media use compared with anxiety levels, and if religiosity had any effect on social media use and anxiety. It also wanted to determine if there was a correlation between religiosity and social media use, and how social media use and religiosity predicted anxiety. This study filled a gap in research by extending previous studies beyond adolescents and by including …

The Moderating Effects Of Adult Attachment And Emotional Intimacy On The Relationship Between Aces And Mental Health In Social Work Students, Cheryl Lind Nitz

Doctoral Dissertations and Projects

Social work students report significantly more adverse childhood experiences (ACEs) than other majors or the general population. ACEs increase the risk of depression, anxiety, and stress (DAS) and can impact students’ ability to effectively serve future clients. Attachment theory and current research suggest a substantial potential therapeutic impact of secure adult attachments, particularly those with high emotional intimacy (EI), for those with ACEs. This study explored the moderating effect of primary adult attachment (PAA) on the relationship between ACEs and mental health. The Adverse Childhood Experiences (ACE-10) Scale, the State Adult Attachment Measure (SAAM), the Functional Analytic Psychotherapy Intimacy Scale …

The Effects Of Crf1 Antagonism On Spatial Navigation And Long-Term Potentiation In The Tgf344-Ad Model Of Alzheimer’S Disease, Nicole C. Reyna

Psychology ETDs

Alzheimer’s disease is characterized by neurobiological deterioration and cognitive impairment that is irreversible. Alzheimer’s disease patients exhibit increased stress system abnormalities including upregulation of the corticotropin releasing factor type 1 receptor (CRF1) and elevated levels of cortisol. People experiencing increased psychological distress in life are more likely to be diagnosed with Alzheimer’s disease and experience faster rates of neurocognitive decline. Therefore, the current dissertation aimed to examine the underlying systems involved in Alzheimer’s disease neuropathology and stress. Administration of the CRF1 antagonist, Antalarmin, reduces AD pathogenesis and anxiety-like behavior in models of Alzheimer’s disease. Thus, the current project used the …