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Animals

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Monoclonal Antibodies To Novel Myeloid Antigens Reveal Human Neutrophil Heterogeneity., Edward D. Ball, Robert F. Graziano, Li Shen, Michael W. Fanger Sep 1982

Monoclonal Antibodies To Novel Myeloid Antigens Reveal Human Neutrophil Heterogeneity., Edward D. Ball, Robert F. Graziano, Li Shen, Michael W. Fanger

Dartmouth Scholarship

Three cytotoxic murine monoclonal antibodies that recognize myeloid-specific antigens have been produced by immunization with normal human neutrophils or myeloblasts from a patient with acute myelomonocytic leukemia. Two of these, PMN 6 and PMN 29, are specific for neutrophils; the third monoclonal antibody, AML-2-23, is reactive with the majority of normal monocytes as well as a subpopulation of mature neutrophils. Although neutrophils from all individuals tested expressed these antigens, cytofluorographic analysis revealed that the percentage of cells bearing the PMN 6 and AML-2-23 antigens varied among individuals. Significant additional heterogeneity in the density of each antigen among antigen-bearing cells was …


Reverence For Life: An Ethic For High School Biology Curricula, George K. Russell Jan 1980

Reverence For Life: An Ethic For High School Biology Curricula, George K. Russell

Education Collection

Ethical and pedagogical arguments are presented against the use of animals by high school students in experiments causing pain/suffering/death of the animal. No justification is seen for such experimentation when perfectly valid alternatives, using noninvasive techniques, exist or could be developed. An important concern is the emotional and psychological growth of young people. An overall objective of high school biology curricula must be to assist students in making viable connections with living biological processes and the natural world.