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Yoga Bunny, Haley Cook Dec 2018

Yoga Bunny, Haley Cook

Children's Book and Media Review

Bunny starts his morning with a yoga sequence. As he does downward dog, forward fold, and tree pose, many of his friends run by. Bunny invites each of them to come and join him in the routine, but they all have excuses. Lizard is too angry, Fox thinks it’s silly, and Bird is too busy trying to cure his hiccups to stop. Bunny is discouraged, but continues to practice, deciding that practicing yoga is better alone than not at all. Eventually, a few friends join Bunny and they are able to practice yoga together.

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Waiting, Acacia Haws Dec 2018

Waiting, Acacia Haws

Children's Book and Media Review

Five toys sit on a windowsill together, each waiting for different things. A dog on a sled is waiting for the snow. A teddy bear is waiting for the wind so he can fly his kite. When the things they’re waiting for happen, the toys are happy. The rabbit toy isn’t waiting for anything in particular but just enjoys waiting and watching the world with the others. They watch the seasons change and the celebration of holidays, like fireworks on the Fourth of July. They see storms and rainbows. New toys join them. One of the toys falls off and …

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Skye The Puffling, Kati Penovich Dec 2018

Skye The Puffling, Kati Penovich

Children's Book and Media Review

Skye, the fluffy gray puffling, is born to adoring parents, who unfortunately are fast asleep one morning when she goes adventuring and falls onto the back of a gannet flying due south. Skye’s parents search high and low for the little puffling; all the while, Skye is riding farther and farther from her home and her parents. Skye’s situation becomes perilous when she falls into the ocean, but luckily her new gannet friend helps her out of the water and flies her to safety. Skye is soon reunited with her devoted parents and they spend the summer with the gannets …

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Deadliest! 20 Dangerous Animals, Makayla Anderson Dec 2018

Deadliest! 20 Dangerous Animals, Makayla Anderson

Children's Book and Media Review

Dangerous animals are everywhere. This book compiles a list of the twenty most dangerous and deadly animals across the world. From venomous animals that live in the ocean to ravenous mammals on land, the most dangerous animals are all around us. Page by page, the reader will learn facts about each animal, including their location on the globe and their size compared to a human.

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Be Glad Your Dad Is Not An Octopus, Shelby Bunker Dec 2018

Be Glad Your Dad Is Not An Octopus, Shelby Bunker

Children's Book and Media Review

Be Glad Your Dad Is Not an Octopus by Matthew Logelin and Sara Jensen is a humorous story of a brother and sister who recognize their dad isn’t perfect and make plans for a new one! However, if their dad was any number of animals, they might be in a worse situation. The kids learn that, in the end, maybe their dad isn’t so bad after all.

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Animal Journeys, Haley Singleton Dec 2018

Animal Journeys, Haley Singleton

Children's Book and Media Review

Animal Journeys details the journeys of many different animals, with some traveling huge expanses of land and others hardly moving more than a few feet throughout their lifetime. Patricia Hegarty starts by showing all of the long distance migrating animals traveling up to 57,000 miles. From Arctic terns to ruby-throated hummingbirds, each animal has a unique journey. Hegarty then explores several marine animals that migrate, including reindeer, hippopotamuses, and humpback whales. Migrating animals who live in extreme temperatures come next in the book, including the fennec fox and the dung beetle, and then the book ends by sharing the interesting …

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Amy The Red Panda Is Writing The Best Story In The World, Loretta Farnsworth Dec 2018

Amy The Red Panda Is Writing The Best Story In The World, Loretta Farnsworth

Children's Book and Media Review

Amy the red panda starts composing a story, but then the letters explode and declare that she is writing the best story in the world. Before she can resume telling her story, however, her friends gather around and begin making suggestions. Upset at being unable to tell her story, Amy tears down the words. Her best friend, Mervin the sloth, helps cheer her up, and she finishes by writing “Amy and Mervin had a fun day.” The rest of their friends reappear to compliment the sentence and request another story.

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The Fintastic Fish Sitter, Kaley Durney Dec 2018

The Fintastic Fish Sitter, Kaley Durney

Children's Book and Media Review

Tom and his friend Pradeep have a pet goldfish named Frankie, and Tom’s brother has a kitten named Fang. Fang and Frankie really don’t get along. This becomes a challenge when Tom and Pradeep ask Pradeep’s sister Sami to fish-sit for them. They give her a list of things to help her, and her biggest task it to keep Fang and Frankie away from each other. That is really hard to do, so she finally tells them that if they can’t play together, they will have to play her games. Since they can't get along, she dresses them up as …

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Mama Lion Wins The Race, Kimberly Jackson Dec 2018

Mama Lion Wins The Race, Kimberly Jackson

Children's Book and Media Review

It’s the morning of the big race and Mama Lion and Tigey are ready to go! They start off with an early lead, until they have to swerve off the road suddenly to avoid running into a butterfly. Fortunately they aren’t out of the race for long, thanks to the Flying Pandinis, who get their vehicle up and running in no time. Mama Lion and Tigey are actually catching up to the leaders, but in the end, they decide to forfeit in favor of the Flying Pandinis. Tigey realizes that the friendship they gained that day was worth more than …

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Libby And Pearl: The Best Of Friends, Beverly Jones Dec 2018

Libby And Pearl: The Best Of Friends, Beverly Jones

Children's Book and Media Review

Libby and Pearl: The Best of Friends is the precious story of a little girl and her pet pig. There is a very special message in this book about unlikely friendship. As the author says, these two are a funny pair, but that doesn't matter. Friends don't have to be exactly the same or even look alike. Friends come in all shapes and sizes. On each page of this book, there is a colorful photograph of some of Libby and Pearl's fun adventures. Life is always more fun with a friend!

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Who's In The Jungle, Bailey Ondricek Dec 2018

Who's In The Jungle, Bailey Ondricek

Children's Book and Media Review

Who’s in the Jungle by Judy Nayer is a charming, sing-song story that introduces young readers to a slew of exciting animals in their traipse through thick of the forest. The story repeats the phrase “Someone’s in the jungle, who can it be?” and guides the reader through the various jungle animals, from monkeys to birds to lion cubs, revealing, in the end, a charming child narrator who has been on the jungle walk.

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Porcupine's Picnic Who Eats What?, Kaley Durney Dec 2018

Porcupine's Picnic Who Eats What?, Kaley Durney

Children's Book and Media Review

Porcupine has finally found the perfect picnic spot! Now he just needs some friends to eat with him. Many of his friends won’t eat clover, but he finds out what each of his friends like to eat. Giraffe like to eat leaves and buds, while Panda likes to eat bamboo. Bear likes blueberries and Kookaburra likes to eat spiders. Tiger comes along, and he likes to eat all of the animals!

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Morris Mole, Melissa Secor Dec 2018

Morris Mole, Melissa Secor

Children's Book and Media Review

Morris lives in the ground with all of his older brothers. He is the smallest mole, and he always does what his brothers do: dig all day and all night. Then one day, the moles run out of food. Morris has an idea, but he is too small and his brothers can’t hear him. So he decides to dig down inside himself and find all of his bravery. Then he does what his brothers have never been done before- he digs up! The world is full of light, friends, and so much food. He meets friends whom he helps save …

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Make It Now: Animals, Karen Abbott Dec 2018

Make It Now: Animals, Karen Abbott

Children's Book and Media Review

This is a novel little book! There is no story, just adorable paper-doll forest animals with stands and accessories that can be popped-out for creative play. There is space on each doll for a child to color some portion of the animal or scenery. A colorful page of stickers is included on the last page for some additional personalization. Children can create a story of their own over and over again as they place and pretend with the figures.

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Life In The Ocean: The Story Of Oceanographer Sylvia Earle, Cynthia Phillips Dec 2018

Life In The Ocean: The Story Of Oceanographer Sylvia Earle, Cynthia Phillips

Children's Book and Media Review

Sylvia Earle has spent more than seven thousand hours underwater and has dedicated her life to studying the ocean. When she was a little girl she was given ample opportunities to study and explore her surroundings. She called her curiosity “investigations” and was determined from a young age to explore the ocean. She walked on the ocean floor deeper than anyone has ever walked, helped design underwater equipment, and enthusiastically observed ocean life. Sylvia Earle has become an advocate for protecting the sea. This picture book biography is about an amazing woman who changed the world.

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Goats, Kristie Hinckley Dec 2018

Goats, Kristie Hinckley

Children's Book and Media Review

Goats live in the wild, but are also kept by people. Their hooves allow them to climb without slipping, which is one of their unique characteristics. Most goats are back, brown, or white. Some have spots or markings on them. Goats have horns and beards. They eat leaves, grass, grain, hay, and salt. People use goats for their milk and their meat. They can be friendly enough to keep as a pet! While male goats are called billy goats, females are called nannies and baby goats are called kids.

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Captain, Taylor Harris Dec 2018

Captain, Taylor Harris

Children's Book and Media Review

Fifteen-year-old Billy joined the army and is being sent off to fight the Turks in Gallipoli. On the way there, he meets a boy named Captain and his donkey, Hey-Ho, who are in the service corps and are sent along with Billy’s platoon. They move from battle to battle, experiencing the horrors of war, but amidst all the fighting, Captain and Hey-Ho are always there providing relief to the troops, especially Billy. Captain and Billy develop a close friendship as they are both far underage. Two years later, fatigued and delusional, Billy accidentally shoots Captain and it almost destroys him. …

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Bayberry Island: An Adventure About Friendship And The Journey Home, Taylor Harris Dec 2018

Bayberry Island: An Adventure About Friendship And The Journey Home, Taylor Harris

Children's Book and Media Review

Twig and his friends, Lily and Basil, set off to take their baby dragon, Char, home. While sailing, they must find their way around a beaver dam, food shortage, and even a mighty storm. Their ship sinks, shipwrecking them on an island where they discover more baby dragons, Char’s siblings. When it becomes apparent that the dragons are fine on their own, Lily and Twig start building a way to go home. To their surprise, their enemy from back home, Professor Burdock, appears and with Basil’s help tries to smuggle the baby dragons off the island. Lily and Twig fight …

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Expanding The Use Of Spectral Libraries In Proteomics., Eric W Deutsch, Yasset Perez-Riverol, Robert J Chalkley, Mathias Wilhelm, Stephen Tate, Timo Sachsenberg, Mathias Walzer, Lukas Käll, Bernard Delanghe, Sebastian Böcker, Emma L Schymanski, Paul Wilmes, Viktoria Dorfer, Bernhard Kuster, Pieter-Jan Volders, Nico Jehmlich, Johannes P C Vissers, Dennis W Wolan, Ana Y Wang, Luis Mendoza, Jim Shofstahl, Andrew W Dowsey, Johannes Griss, Reza M Salek, Steffen Neumann, Pierre-Alain Binz, Henry Lam, Juan Antonio Vizcaíno, Nuno Bandeira, Hannes Röst Dec 2018

Expanding The Use Of Spectral Libraries In Proteomics., Eric W Deutsch, Yasset Perez-Riverol, Robert J Chalkley, Mathias Wilhelm, Stephen Tate, Timo Sachsenberg, Mathias Walzer, Lukas Käll, Bernard Delanghe, Sebastian Böcker, Emma L Schymanski, Paul Wilmes, Viktoria Dorfer, Bernhard Kuster, Pieter-Jan Volders, Nico Jehmlich, Johannes P C Vissers, Dennis W Wolan, Ana Y Wang, Luis Mendoza, Jim Shofstahl, Andrew W Dowsey, Johannes Griss, Reza M Salek, Steffen Neumann, Pierre-Alain Binz, Henry Lam, Juan Antonio Vizcaíno, Nuno Bandeira, Hannes Röst

Articles, Abstracts, and Reports

The 2017 Dagstuhl Seminar on Computational Proteomics provided an opportunity for a broad discussion on the current state and future directions of the generation and use of peptide tandem mass spectrometry spectral libraries. Their use in proteomics is growing slowly, but there are multiple challenges in the field that must be addressed to further increase the adoption of spectral libraries and related techniques. The primary bottlenecks are the paucity of high quality and comprehensive libraries and the general difficulty of adopting spectral library searching into existing workflows. There are several existing spectral library formats, but none captures a satisfactory level …

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Flexible And Fast Mapping Of Peptides To A Proteome With Proteomapper., Luis Mendoza, Eric W Deutsch, Zhi Sun, David S Campbell, David Shteynberg, Robert L Moritz Dec 2018

Flexible And Fast Mapping Of Peptides To A Proteome With Proteomapper., Luis Mendoza, Eric W Deutsch, Zhi Sun, David S Campbell, David Shteynberg, Robert L Moritz

Articles, Abstracts, and Reports

Bottom-up proteomics relies on the proteolytic or chemical cleavage of proteins into peptides, the identification of those peptides via mass spectrometry, and the mapping of the identified peptides back to the reference proteome to infer which possible proteins are identified. Reliable mapping of peptides to proteins still poses substantial challenges when considering similar proteins, protein families, splice isoforms, sequence variation, and possible residue mass modifications, combined with an imperfect and incomplete understanding of the proteome. The ProteoMapper tool enables a comprehensive and rapid mapping of peptides to a reference proteome. The indexer component creates a segmented index for an input …

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Cd4+ T Cells Induce Rejection Of Urothelial Tumors After Immune Checkpoint Blockade, Yuji Sato, Jennifer K Bolzenius, Abdallah M Eteleeb, Xinming Su, Christopher A Maher, Jennifer K Sehn, Vivek K Arora Dec 2018

Cd4+ T Cells Induce Rejection Of Urothelial Tumors After Immune Checkpoint Blockade, Yuji Sato, Jennifer K Bolzenius, Abdallah M Eteleeb, Xinming Su, Christopher A Maher, Jennifer K Sehn, Vivek K Arora

Open Access Publications

Immune checkpoint blockade (ICB) provides clinical benefit to a minority of patients with urothelial carcinoma (UC). The role of CD4+ T cells in ICB-induced antitumor activity is not well defined; however, CD4+ T cells are speculated to play a supportive role in the development of CD8+ T cells that kill tumor cells after recognition of tumor antigens presented by MHC class I. To investigate the mechanisms of ICB-induced activity against UC, we developed mouse organoid-based transplantable models that have histologic and genetic similarity to human bladder cancer. We found that ICB can induce tumor rejection and protective immunity with these …

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Making Covenants With Brute Beasts: Making Room For Non-Human Animals In A Contractualist Framework, Jennifer Lynn Burgis Dec 2018

Making Covenants With Brute Beasts: Making Room For Non-Human Animals In A Contractualist Framework, Jennifer Lynn Burgis

Open Access Dissertations

In this dissertation I explore the question of whether T.M. Scanlon's contractualist ethical theory can be revised such that the resulting theory makes room for moral obligations to non-human animals. A number of attempts have been made to justify our intuitions regarding the treatment of animals, but none of these has succeeded. I argue that Scanlon's reliance on the rationality criterion is flawed and that a focus on moral capacities creates both a more inclusive and a more satisfying moral framework. By building on Julia Driver's objective consequentialist account of virtue, I am able to support the claim that, at …

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Targeting The Brd4/Foxo3a/Cdk6 Axis Sensitizes Akt Inhibition In Luminal Breast Cancer, Jingyi Liu, Weijie Guo, Zhibing Duan, Lei Zeng, Yadi Wu, Yule Chen, Fang Tai, Yifan Wang, Yiwei Lin, Qiang Zhang, Yanling He, Jiong Deng, Rachel L. Stewart, Chi Wang, Pengnian Charles Lin, Saghi Ghaffari, B. Mark Evers, Suling Liu, Ming-Ming Zhou, Binhua P. Zhou, Jian Shi Dec 2018

Targeting The Brd4/Foxo3a/Cdk6 Axis Sensitizes Akt Inhibition In Luminal Breast Cancer, Jingyi Liu, Weijie Guo, Zhibing Duan, Lei Zeng, Yadi Wu, Yule Chen, Fang Tai, Yifan Wang, Yiwei Lin, Qiang Zhang, Yanling He, Jiong Deng, Rachel L. Stewart, Chi Wang, Pengnian Charles Lin, Saghi Ghaffari, B. Mark Evers, Suling Liu, Ming-Ming Zhou, Binhua P. Zhou, Jian Shi

Molecular and Cellular Biochemistry Faculty Publications

BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer progression. However, it remains unclear whether BRD4-mediated gene transcription is required for tumor cells to develop drug resistance. Our data show that prolonged treatment of luminal breast cancer cells with AKT inhibitors induces FOXO3a dephosphorylation, nuclear translocation, and disrupts its association with SirT6, eventually leading to FOXO3a acetylation as well as BRD4 recognition. Acetylated FOXO3a recognizes the BD2 domain of BRD4, recruits the BRD4/RNAPII complex to the CDK6 gene promoter, and induces its transcription. Pharmacological inhibition of either BRD4/FOXO3a association or …

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Uren, Doris Et Al. (Fa 1233), Manuscripts & Folklife Archives Dec 2018

Uren, Doris Et Al. (Fa 1233), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid only for Folklife Archives Project 1233. Student folk studies project titled “Märchen [Fairy tales],” which includes survey sheets with a description of a fairy tale collected in Kentucky and Tennessee by students at Campbellsville College, Kentucky. Sheets may include a brief description of a fairy tale, informant’s name, age and address. The first name of the collectors Asher and Wall were not provided.

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Thyrotropin Receptor Blocking Antibodies, Tanja Diana, Paul D. Olivo, George J. Kahaly Dec 2018

Thyrotropin Receptor Blocking Antibodies, Tanja Diana, Paul D. Olivo, George J. Kahaly

2010-2019 OA Pubs

Autoantibodies (Ab) against the thyroid-stimulating hormone receptor (TSHR) are frequently found in autoimmune thyroid disease (AITD). Autoantibodies to the TSHR (anti-TSHR-Ab) may mimic or block the action of TSH or be functionally neutral. Measurement of anti-TSHR-Ab can be done either via competitive-binding immunoassays or with functional cell-based bioassays. Antibody-binding assays do not assess anti-TSHR-Ab functionality, but rather measure the concentration of total anti-TSHR binding activity. In contrast, functional cell-based bioassays indicate whether anti-TSHR-Ab have stimulatory or blocking activity. Historically bioassays for anti-TSHR-Ab were research tools and were used to study the pathophysiology of Graves' disease and Hashimoto's thyroiditis. In the …

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Morphometric Characteristics And Time To Hatch As Efficacious Indicators For Potential Nanotoxicity Assay In Zebrafish, Seyed-Mohammadreza Samaee, Nafiseh Manteghi, Robert A. Yokel, Mohammad Reza Mohajeri-Tehrani Dec 2018

Morphometric Characteristics And Time To Hatch As Efficacious Indicators For Potential Nanotoxicity Assay In Zebrafish, Seyed-Mohammadreza Samaee, Nafiseh Manteghi, Robert A. Yokel, Mohammad Reza Mohajeri-Tehrani

Pharmaceutical Sciences Faculty Publications

Although the effects of nano-sized titania (nTiO2) on hatching events (change in hatching time and total hatching) in zebrafish have been reported, additional consequences of nTiO2 exposure (i.e., the effects of nTiO2-induced changes in hatching events and morphometric parameters on embryo-larvae development and survivability) have not been reported. To address this knowledge gap, embryos 4 h postfertilization were exposed to nTiO2 (0, 0.01, 10, and 1000 μg/mL) for 220 h. Hatching rate (58, 82, and 106 h postexposure [hpe]), survival rate (8 times from 34 to 202 hpe), and 21 morphometric characteristics (8 times …

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Lrrk1 Regulation Of Actin Assembly In Osteoclasts Involves Serine 5 Phosphorylation Of L-Plastin, Mingjue Si, Helen Goodluck, Canjun Zeng, Songqin Pan, Elizabeth M Todd, Sharon Celeste Morley, Xuezhong Qin, Subburaman Mohan, Weirong Xing Dec 2018

Lrrk1 Regulation Of Actin Assembly In Osteoclasts Involves Serine 5 Phosphorylation Of L-Plastin, Mingjue Si, Helen Goodluck, Canjun Zeng, Songqin Pan, Elizabeth M Todd, Sharon Celeste Morley, Xuezhong Qin, Subburaman Mohan, Weirong Xing

Open Access Publications

Mice with disruption of Lrrk1 and patients with nonfunctional mutant Lrrk1 exhibit severe osteopetrosis phenotypes because of osteoclast cytoskeletal dysfunction. To understand how Lrrk1 regulates osteoclast function by modulating cytoskeleton rearrangement, we examined the proteins that are differentially phosphorylated in wild-type mice and Lrrk1-deficient osteoclasts by metal affinity purification coupled liquid chromatography/mass spectrometry (LC/MS) analyses. One of the candidates that we identified by LC/MS is L-plastin, an actin bundling protein. We found that phosphorylation of L-plastin at serine (Ser) residues 5 was present in wild-type osteoclasts but not in Lrrk1-deficient cells. Western blot analyses with antibodies specific for Ser5 phosphorylated …

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Law Library Blog (December 2018) : Legal Beagle's Blog Archive, Roger Williams University School Of Law Dec 2018

Law Library Blog (December 2018) : Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.

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Associative And Non-Associative Learning In The Monodelphis Domestica, Ana C. Ramirez Dec 2018

Associative And Non-Associative Learning In The Monodelphis Domestica, Ana C. Ramirez

Theses and Dissertations

Learning encompasses multiple important processes that vary within organisms and that are affected by different factors. Two of the most important types of learning are associative and non-associative learning. Even though past research has studied animal learning in multiple species, there is limited research on learning in the Monodelphis domestica. It is imperative to further the knowledge on this species since multiple fields use it as an animal model for research. The current study examined both non-associative and associative learning in the Monodelphis. Non-associative learning was explored by using a habituation-dishabituation paradigm, while associative learning was examined using the …

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Rapid And Robust Restoration Of Breathing Long After Spinal Cord Injury, Philippa M. Warren, Stephanie C. Steiger, Thomas E. Dick, Peter M. Macfarlane, Warren J. Alilain, Jerry Silver Nov 2018

Rapid And Robust Restoration Of Breathing Long After Spinal Cord Injury, Philippa M. Warren, Stephanie C. Steiger, Thomas E. Dick, Peter M. Macfarlane, Warren J. Alilain, Jerry Silver

Spinal Cord and Brain Injury Research Center Faculty Publications

There exists an abundance of barriers that hinder functional recovery following spinal cord injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 years following cervical hemisection in the rat. In spite of complete hemidiaphragm paralysis, a single injection of chondroitinase ABC in the phrenic motor pool restored robust and persistent diaphragm function while improving neuromuscular junction anatomy. This treatment strategy was more effective when applied chronically than when assessed acutely after injury. The addition of intermittent hypoxia conditioning further strengthened the ventilatory response. However, in a sub-population of animals, this combination treatment caused excess …

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