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Beyond Words—What Elephants And Whales Think And Feel, Leah Christopher Apr 2022

Beyond Words—What Elephants And Whales Think And Feel, Leah Christopher

Children's Book and Media Review

Carl Safina, an animal conservationist, investigates the similarities between wild animals and humans by traveling the world and learning from experts. In Kenya, he learns about the playfulness, ingenuity, and sensitivity of elephants, finding that these large animals perform their own mourning rituals. In the Pacific Northwest, he studies killer whales’ creativity, adaptability, and thoughtfulness, learning that whales once led a boat to rescue a missing sailor three miles away. Through his travels, Safina becomes aware of the dangers to animals’ lands and lives. For example, the poaching of one elephant dismantles the leadership of the whole family, and the …

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Wild Child #1: Forest's First Home, Jessica Mellor Apr 2022

Wild Child #1: Forest's First Home, Jessica Mellor

Children's Book and Media Review

Olive, Ryan, and their dad are all on a camping trip. While walking their dog Bailey one last time before packing up their campsite, Bailey gets free and runs off. Bailey is found by none other than a wild boy named Forest, who has clothes made out of leaves and sticks. When they get home, they find another surprise - Forest is sleeping in their backseat! Times at their house are full of fun as Forest gets used to living inside. But he has to learn his manners before Gam Gam’s birthday party that evening to see if he can …

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What The Ladybug Heard At The Zoo, Krista Alletto Apr 2022

What The Ladybug Heard At The Zoo, Krista Alletto

Children's Book and Media Review

Ladybug is spending the day enjoying the sights and sounds of town. Suddenly, she overhears robbers Hefty Hugh and Lanky Len scheming to kidnap Monkey Joe from the zoo to be a player in their royal crown heist plan. Ladybug spreads the word to all her animal friends, including the Queen’s own two corgi dogs, and puts together a plan to frustrate the two robbers’ plans. After they make sure that Hefty Hugh and Lanky Len never come back to cause trouble again, all the animals celebrate their success!

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Scary Stories For Young Foxes, Jessica Mellor Apr 2022

Scary Stories For Young Foxes, Jessica Mellor

Children's Book and Media Review

Seven little fox kits beg their mother for a scary story, but when they receive none they decide to go to the scariest storyteller in the forest. Rising up from a stack of bones, the teller tells the tale of two fox families that romped through the land long ago. The first fox is Mia, forced to leave her home when disease strikes the ones she loves most. Ully is the runt of a litter with a small shriveled paw, mocked by his other sisters. When Mr. Scratch comes to visit, Ully’s life is threatened to the point where he …

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Oh No, Bobo! You’Re In Trouble, Liz Kazandzhy Apr 2022

Oh No, Bobo! You’Re In Trouble, Liz Kazandzhy

Children's Book and Media Review

The mischievous monkey Bobo just can't resist stealing the zookeeper’s flashlight. But when he and his koala friend Fifi start playing with it, the flashlight stops working, to which Fifi is quick to respond “You’re in … TROUBLE!” Fifi’s exclamations soon catch the attention of all the zoo animals. They watch as Bobo unsuccessfully tries to fix the flashlight and then frantically runs around asking for help, which only makes the situation worse. Fifi eventually promises not to tattle on Bobo, but only in exchange for some compliments. Finally, when the zookeeper finds the flashlight, it turns out the problem …

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I Am A Tiger, Jessica Mellor Apr 2022

I Am A Tiger, Jessica Mellor

Children's Book and Media Review

Mouse proclaims to all that he is the mighty tiger. All the other animals try and name the characteristics of a tiger and how a little mouse might not fit them—but mouse has an explanation for each of them. When a real tiger shows up Mouse still plays the game, and by looking at certain characteristics convinces this tiger he is really something less scary. This extends to all the animals. The birds are simply lollipops and that yellow snake a banana. Mouse is never satisfied though, finally convincing himself he is much mightier than even the greatest beast around.

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You're Here For A Reason, Lindsey Smith Apr 2022

You're Here For A Reason, Lindsey Smith

Children's Book and Media Review

We all matter - it is an important thing to remember, especially on the hard days. This is a message that everyone needs, and in this book, the author targets that message to children. She shows that even the smallest decisions can have great consequences, that we can learn from one another, and that we all make an impact on the people and world around us.

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Grumpy Duck, Ellen Mccarty Apr 2022

Grumpy Duck, Ellen Mccarty

Children's Book and Media Review

Duck was in a grumpy mood. Nothing was good enough. The pond was dry, she had no one to play with, and a small gray cloud hovered over her head. She approached each of her friends in turn - dog, pig, rooster, rabbit, tortoise, and goat. Each invited her to join them, but she was too grumpy. Her gray cloud grew and her grumpiness spread. At last, the cloud was ginormous and black, covering all the animals. It burst in a huge downpour of raindrops. The animals started splashing and singing, their gloom washing away with the rain.

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Even More Lesser Spotted Animals, Amanda Morgan Apr 2022

Even More Lesser Spotted Animals, Amanda Morgan

Children's Book and Media Review

Meet the underdogs of the animal kingdom. they're not as praised as lions, tigers and other big shot mammals, but this book is here to show you why they should be. The dingiso basically looks like a living breathing teddy bear and can jump to the ground from a 60 foot tree without receiving injury. The forest musk deer, unlike real deer, hangs out in trees. The little yellow-throated marten which, as the name suggests, has bright yellow fur, can take down an entire deer. The gerenuk and the dibatags are antelope with necks like giraffes. In learning about all …

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Reduction Of Mutant Atxn1 Rescues Premature Death In A Conditional Sca1 Mouse Model, James P Orengo, Larissa Nitschke, Meike E Van Der Heijden, Nicholas A Ciaburri, Harry T Orr, Huda Y Zoghbi Apr 2022

Reduction Of Mutant Atxn1 Rescues Premature Death In A Conditional Sca1 Mouse Model, James P Orengo, Larissa Nitschke, Meike E Van Der Heijden, Nicholas A Ciaburri, Harry T Orr, Huda Y Zoghbi

Duncan NRI Faculty and Staff Publications

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset neurodegenerative disorder. As disease progresses, motor neurons are affected, and their dysfunction contributes toward the inability to maintain proper respiratory function, a major driving force for premature death in SCA1. To investigate the isolated role of motor neurons in SCA1, we created a conditional SCA1 (cSCA1) mouse model. This model suppresses expression of the pathogenic SCA1 allele with a floxed stop cassette. cSCA1 mice crossed to a ubiquitous Cre line recapitulate all the major features of the original SCA1 mouse model; however, they took twice as long to develop. We found that …

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A Somatic Mutation In Moesin Drives Progression Into Acute Myeloid Leukemia, Ouyang Yuan, Jeffrey A Magee, Et Al. Apr 2022

A Somatic Mutation In Moesin Drives Progression Into Acute Myeloid Leukemia, Ouyang Yuan, Jeffrey A Magee, Et Al.

Open Access Publications

Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provide insights into the biology of transformation but also reveal novel therapeutic opportunities. However, backtracking these events in transformed human AML samples is challenging, if at all possible. Here, we approached this question using a murine in vivo model with an MLL-ENL fusion protein as a primary molecular event. Upon clonal transformation, we identified and extensively verified a recurrent codon-changing mutation (Arg

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Retrospective Genomics Highlights Changes In Genetic Composition Of Tiger Sharks (Galeocerdo Cuvier) And Potential Loss Of A South-Eastern Australia Population, Alice Manuzzi, Belen Jiménez-Mena, Romina Henriques, Bonnie J Holmes, Julian Pepperell, Janette Edson, Mike B Bennett, Charlie Huveneers, Jennifer R Ovenden, Einar E Nielsen Apr 2022

Retrospective Genomics Highlights Changes In Genetic Composition Of Tiger Sharks (Galeocerdo Cuvier) And Potential Loss Of A South-Eastern Australia Population, Alice Manuzzi, Belen Jiménez-Mena, Romina Henriques, Bonnie J Holmes, Julian Pepperell, Janette Edson, Mike B Bennett, Charlie Huveneers, Jennifer R Ovenden, Einar E Nielsen

Staff and Researcher Publications

Over the last century, many shark populations have declined, primarily due to overexploitation in commercial, artisanal and recreational fisheries. In addition, in some locations the use of shark control programs also has had an impact on shark numbers. Still, there is a general perception that populations of large ocean predators cover wide areas and therefore their diversity is less susceptible to local anthropogenic disturbance. Here we report on temporal genomic analyses of tiger shark (Galeocerdo cuvier) DNA samples that were collected from eastern Australia over the past century. Using Single Nucleotide Polymorphism (SNP) loci, we documented a significant change in …

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Murine Respiratory Tract Infection With Classical Klebsiella Pneumoniae Induces Bronchus-Associated Lymphoid Tissue, Rachel K Wasbotten, Aubree A Dahler, Joseph J Mackel, Catherine Morffy Smith, David A Rosen Apr 2022

Murine Respiratory Tract Infection With Classical Klebsiella Pneumoniae Induces Bronchus-Associated Lymphoid Tissue, Rachel K Wasbotten, Aubree A Dahler, Joseph J Mackel, Catherine Morffy Smith, David A Rosen

Open Access Publications

Klebsiella pneumoniae is a Gram-negative, opportunistic pathogen that commonly causes nosocomial pneumonia, urinary tract infection, and septicemia. Our recent work utilizing a murine model of respiratory tract infection with classical K. pneumoniae demonstrated leukocyte aggregates in the lungs of mice at 28 days postinfection. Here, we sought to characterize the composition and development of these structures. Histopathological analyses of murine lungs revealed immune cell clusters surrounding the pulmonary vasculature and airways by 14 days postinfection, resembling inducible bronchus-associated lymphoid tissue (iBALT). Further investigation of these structures demonstrated central B cell aggregates with concomitant dispersed T cells. At day 28 postinfection, …

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Preclinical Characterization And Target Validation Of The Antimalarial Pantothenamide Mmv693183., Laura E. De Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering Apr 2022

Preclinical Characterization And Target Validation Of The Antimalarial Pantothenamide Mmv693183., Laura E. De Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering

Natural Sciences and Mathematics | Faculty Scholarship

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclinical development. Our studies demonstrate attractive drug-like properties and in vivo efficacy in a humanized mouse model of Plasmodium falciparum infection. The compound shows single digit nanomolar in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocks P. falciparum transmission to Anopheles mosquitoes. Genetic and biochemical studies identify AcAS as the target of the MMV693183-derived antimetabolite, CoA-MMV693183. Pharmacokinetic-pharmacodynamic modelling predict that a single 30 mg oral dose is sufficient …

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Dynamics Of Huntingtin Protein Interactions In The Striatum Identifies Candidate Modifiers Of Huntington Disease, Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Cristea Apr 2022

Dynamics Of Huntingtin Protein Interactions In The Striatum Identifies Candidate Modifiers Of Huntington Disease, Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Cristea

Duncan NRI Faculty and Staff Publications

Huntington’s disease (HD) is a monogenic neurodegenerative disorder with one causative gene, huntingtin (HTT). Yet, HD pathobiology is multifactorial, suggesting that cellular factors influence disease progression. Here, we define HTT protein-protein interactions (PPIs) perturbed by the mutant protein with expanded polyglutamine in the mouse striatum, a brain region with selective HD vulnerability. Using metabolically labeled tissues and immunoaffinity purification-mass spectrometry, we establish that polyglutamine-dependent modulation of HTT PPI abundances and relative stability starts at an early stage of pathogenesis in a Q140 HD mouse model. We identify direct and indirect PPIs that are also genetic disease modifiers using in-cell two-hybrid …

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Cross-Reactive Antibodies Elicited To Conserved Epitopes On Sars-Cov-2 Spike Protein After Infection And Vaccination., Eric S. Geanes, Cas Lemaster, Elizabeth Fraley, Santosh Khanal, Rebecca Mclennan, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley Apr 2022

Cross-Reactive Antibodies Elicited To Conserved Epitopes On Sars-Cov-2 Spike Protein After Infection And Vaccination., Eric S. Geanes, Cas Lemaster, Elizabeth Fraley, Santosh Khanal, Rebecca Mclennan, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley

Manuscripts, Articles, Book Chapters and Other Papers

SARS-CoV-2 is a novel betacoronavirus that caused coronavirus disease 2019 and has resulted in millions of deaths worldwide. Novel coronavirus infections in humans have steadily become more common. Understanding antibody responses to SARS-CoV-2, and identifying conserved, cross-reactive epitopes among coronavirus strains could inform the design of vaccines and therapeutics with broad application. Here, we determined that individuals with previous SARS-CoV-2 infection or vaccinated with the Pfizer-BioNTech BNT162b2 vaccine produced antibody responses that cross-reacted with related betacoronaviruses. Moreover, we designed a peptide-conjugate vaccine with a conserved SARS-CoV-2 S2 spike epitope, immunized mice and determined cross-reactive antibody binding to SARS-CoV-2 and other …

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Six-Bullets Faith, Justin R. Lazor Apr 2022

Six-Bullets Faith, Justin R. Lazor

ETD Archive

At a religious school of unspecified denomination—but definitely NOT Catholic—two women fall in love. One of them has a chainsaw, the other a gun. There’s also a horny parrot, a horny pastor and a senile mother, not to mention Lucifer, who is a bit of a teenage girl and a HUGE Billie Eilish fan. And the end of the Universe is coming, FYI, via the Big Rip, so there’s that too. And this play is also about addiction and withdrawal and recovery and the capacity or incapacity for love to overcome forces that can overwhelm the self.

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Ror Activation By Nobiletin Enhances Antitumor Efficacy Via Suppression Of Iκb/Nf-Κb Signaling In Triple-Negative Breast Cancer, Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen Apr 2022

Ror Activation By Nobiletin Enhances Antitumor Efficacy Via Suppression Of Iκb/Nf-Κb Signaling In Triple-Negative Breast Cancer, Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor response to standard therapies and therefore unfavorable clinical outcomes. Better understanding of TNBC and new therapeutic strategies are urgently needed. ROR nuclear receptors are multifunctional transcription factors with important roles in circadian pathways and other processes including immunity and tumorigenesis. Nobiletin (NOB) is a natural compound known to display anticancer effects, and our previous studies showed that NOB activates RORs to enhance circadian rhythms and promote physiological fitness in mice. Here, we identified several TNBC cell lines being sensitive to NOB, by itself or in combination. Cell and xenograft …

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Safety And Efficacy Of Systemic Anti-Scg3 Therapy To Treat Oxygen-Induced Retinopathy, Chang Dai, Hong Tian, Amit Bhatt, Guanfang Su, Keith A Webster, Wei Li Apr 2022

Safety And Efficacy Of Systemic Anti-Scg3 Therapy To Treat Oxygen-Induced Retinopathy, Chang Dai, Hong Tian, Amit Bhatt, Guanfang Su, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

BACKGROUND: To circumvent possible systemic side effects, anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) for ocular neovascular diseases in adults are approved only for intravitreal administration. However, intravitreal injection itself can elicit injection-related adverse effects, and premature eyes of infants with retinopathy of prematurity (ROP) may be particularly susceptible to intravitreal injection. Therefore, an unmet clinical need is to develop safe systemic anti-angiogenic therapies for ROP. We recently reported that secretogranin III (Scg3) is a disease-restricted angiogenic factor and that systemic anti-Scg3 mAb alleviates ROP in animal models with minimal side effects on developing eyes and organs. The aim …

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Hyperactivation Is Sufficient To Release Porcine Sperm From Immobilized Oviduct Glycans, Momal Sharif, Vincent Hickl, Gabriel Juarez, Xingjian Di, Karl Kerns, Peter Sutovsky, Nicolai Bovin, David J Miller Apr 2022

Hyperactivation Is Sufficient To Release Porcine Sperm From Immobilized Oviduct Glycans, Momal Sharif, Vincent Hickl, Gabriel Juarez, Xingjian Di, Karl Kerns, Peter Sutovsky, Nicolai Bovin, David J Miller

Faculty, Staff and Students Publications

Fertilizing sperm are retained by adhesion to specific glycans on the epithelium of the oviduct forming a reservoir before sperm are released from the reservoir so fertilization can ensue. Capacitated sperm lose affinity for the oviduct epithelium but the components of capacitation that are important for sperm release are uncertain. One important correlate of capacitation is the development of hyperactivated motility. Hyperactivation is characterized by asymmetrical flagellar beating with high beat amplitude. We tested whether the development of full-type asymmetrical motility was sufficient to release sperm from immobilized oviduct glycans. Sperm hyperactivation was induced by four different compounds, a cell-permeable …

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Safety And Efficacy Of Systemic Anti-Scg3 Therapy To Treat Oxygen-Induced Retinopathy, Chang Dai, Hong Tian, Amit Bhatt, Guanfang Su, Keith A Webster, Wei Li Apr 2022

Safety And Efficacy Of Systemic Anti-Scg3 Therapy To Treat Oxygen-Induced Retinopathy, Chang Dai, Hong Tian, Amit Bhatt, Guanfang Su, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

BACKGROUND: To circumvent possible systemic side effects, anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) for ocular neovascular diseases in adults are approved only for intravitreal administration. However, intravitreal injection itself can elicit injection-related adverse effects, and premature eyes of infants with retinopathy of prematurity (ROP) may be particularly susceptible to intravitreal injection. Therefore, an unmet clinical need is to develop safe systemic anti-angiogenic therapies for ROP. We recently reported that secretogranin III (Scg3) is a disease-restricted angiogenic factor and that systemic anti-Scg3 mAb alleviates ROP in animal models with minimal side effects on developing eyes and organs. The aim …

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Something Rotten: A Fresh Look At Roadkill, Rebecca Lambert Apr 2022

Something Rotten: A Fresh Look At Roadkill, Rebecca Lambert

Children's Book and Media Review

Have you ever wondered what happens to those animals that meet an unfortunate end on the highway? Heather Montgomery, a writer and biologist from Alabama, answers every question you never knew you had about roadkill. Did you know that Tasmanian Devils are endangered, in part because of a contagious cancer? Scientists learned that from roadkill. Did you know that an invasive species of python has brought parasites to the native snakes of Florida? Scientists learned that from roadkill, too. This book explains how flattened animals are used for all sorts of bizarre purposes. Scientists study roadkill to learn more about …

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Monkey Time, Lindsey Smith Apr 2022

Monkey Time, Lindsey Smith

Children's Book and Media Review

Is it possible to make time concrete? In his book Monkey Time, author Michael Hall attempts to do just that. When Monkey wakes up, sixty small minute dots are waiting to play with him. Monkey sits in the middle of a clock and chases each one as it races around it. Pretty soon sixty minutes have gone by, and then the minutes fly away.

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Fire And Furry: Pets Get Political, Amanda Morgan Apr 2022

Fire And Furry: Pets Get Political, Amanda Morgan

Children's Book and Media Review

Politics have gone crazy in the past few years, and these animals are here to tell and show you all about it. Cat-ivists hold signs. A hedgehog laments his small hands. A chihuahua with a doughnut pleads for “Equal bites for all.” After pages of paw-litical puns and adorable animal pictures, a wise owl finishes the book off by telling the reader to “stay woke” in civic and political engagement.

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Duck!, Krista Alletto Apr 2022

Duck!, Krista Alletto

Children's Book and Media Review

The farm is quiet and peaceful. The horse, cow, pig and sheep are all enjoying the afternoon until Duck waddles in and starts yelling “DUCK!” All the animals, believing that Duck is mistaken and confused, become frustrated and try to explain that not all animals are ducks. Amidst the chaos, it becomes clear just what Duck was meaning with his emphatic word. It wasn’t to label the animals as Ducks, but to warn the others of approaching danger. Maybe Duck should have been yelling “RUN!”

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12 Lucky Animals: A Bilingual Baby Book, Hannah Webb Apr 2022

12 Lucky Animals: A Bilingual Baby Book, Hannah Webb

Children's Book and Media Review

What does your Chinese zodiac say about you? Are you hardworking like an ox, or maybe clever and curious like a rat? Find out in Vickie Lee and Joey Chou’s 12 Lucky Animals: A Bilingual Baby Book. The book takes the reader through each of the 12 animals of the Chinese zodiac, outlining their characteristics and giving their names in both English and Chinese. The back of the book features a nifty chart that allows you to see which animal corresponds with your birth year, ranging from 1989-2024.

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Time Dependent Analysis Of Rat Microglial Surface Markers In Traumatic Brain Injury Reveals Dynamics Of Distinct Cell Subpopulations, Assaf Gottlieb, Naama Toledano-Furman, Karthik S Prabhakara, Akshita Kumar, Henry W Caplan, Supinder Bedi, Charles S Cox, Scott D Olson Apr 2022

Time Dependent Analysis Of Rat Microglial Surface Markers In Traumatic Brain Injury Reveals Dynamics Of Distinct Cell Subpopulations, Assaf Gottlieb, Naama Toledano-Furman, Karthik S Prabhakara, Akshita Kumar, Henry W Caplan, Supinder Bedi, Charles S Cox, Scott D Olson

Faculty, Staff and Student Publications

Traumatic brain injury (TBI) results in a cascade of cellular responses, which produce neuroinflammation, partly due to the activation of microglia. Accurate identification of microglial populations is key to understanding therapeutic approaches that modify microglial responses to TBI and improve long-term outcome measures. Notably, previous studies often utilized an outdated convention to describe microglial phenotypes. We conducted a temporal analysis of the response to controlled cortical impact (CCI) in rat microglia between ipsilateral and contralateral hemispheres across seven time points, identified microglia through expression of activation markers including CD45, CD11b/c, and p2y12 receptor and evaluated their activation state using additional …

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Anatomical Variability, Multi-Modal Coordinate Systems, And Precision Targeting In The Marmoset Brain, Takayuki Ose, David C Van Essen, Matthew F Glasser, Et Al. Apr 2022

Anatomical Variability, Multi-Modal Coordinate Systems, And Precision Targeting In The Marmoset Brain, Takayuki Ose, David C Van Essen, Matthew F Glasser, Et Al.

2020-Current year OA Pubs

Localising accurate brain regions needs careful evaluation in each experimental species due to their individual variability. However, the function and connectivity of brain areas is commonly studied using a single-subject cranial landmark-based stereotactic atlas in animal neuroscience. Here, we address this issue in a small primate, the common marmoset, which is increasingly widely used in systems neuroscience. We developed a non-invasive multi-modal neuroimaging-based targeting pipeline, which accounts for intersubject anatomical variability in cranial and cortical landmarks in marmosets. This methodology allowed creation of multi-modal templates (MarmosetRIKEN20) including head CT and brain MR images, embedded in coordinate systems of anterior and …

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Cs1 Car-T Targeting The Distal Domain Of Cs1 (Slamf7) Shows Efficacy In High Tumor Burden Myeloma Model Despite Fratricide Of Cd8+Cs1 Expressing Car-T Cells, Julie O'Neal, Julie K Ritchey, Matthew L Cooper, Jessica Niswonger, L Sofía González, Emily Street, Michael P Rettig, Susan W Gladney, Leah Gehrs, Ramzi Abboud, Julie L Prior, Gabriel J Haas, Reyka G Jayasinghe, Li Ding, Armin Ghobadi, Ravi Vij, John F Dipersio Apr 2022

Cs1 Car-T Targeting The Distal Domain Of Cs1 (Slamf7) Shows Efficacy In High Tumor Burden Myeloma Model Despite Fratricide Of Cd8+Cs1 Expressing Car-T Cells, Julie O'Neal, Julie K Ritchey, Matthew L Cooper, Jessica Niswonger, L Sofía González, Emily Street, Michael P Rettig, Susan W Gladney, Leah Gehrs, Ramzi Abboud, Julie L Prior, Gabriel J Haas, Reyka G Jayasinghe, Li Ding, Armin Ghobadi, Ravi Vij, John F Dipersio

2020-Current year OA Pubs

Despite improvement in treatment options for myeloma patients, including targeted immunotherapies, multiple myeloma remains a mostly incurable malignancy. High CS1 (SLAMF7) expression on myeloma cells and limited expression on normal cells makes it a promising target for CAR-T therapy. The CS1 protein has two extracellular domains - the distal Variable (V) domain and the proximal Constant 2 (C2) domain. We generated and tested CS1-CAR-T targeting the V domain of CS1 (Luc90-CS1-CAR-T) and demonstrated anti-myeloma killing in vitro and in vivo using two mouse models. Since fratricide of CD8 + cells occurred during production, we generated fratricide resistant CS1 deficient Luc90- …

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Neuronal Origins Of Reduced Accuracy And Biases In Economic Choices Under Sequential Offers, Weikang Shi, Sebastien Ballesta, Camillo Padoa-Schioppa Apr 2022

Neuronal Origins Of Reduced Accuracy And Biases In Economic Choices Under Sequential Offers, Weikang Shi, Sebastien Ballesta, Camillo Padoa-Schioppa

2020-Current year OA Pubs

Economic choices are characterized by a variety of biases. Understanding their origins is a long-term goal for neuroeconomics, but progress on this front has been limited. Here, we examined choice biases observed when two goods are offered sequentially. In the experiments, rhesus monkeys chose between different juices offered simultaneously or in sequence. Choices under sequential offers were less accurate (higher variability). They were also biased in favor of the second offer (order bias) and in favor of the preferred juice (preference bias). Analysis of neuronal activity recorded in the orbitofrontal cortex revealed that these phenomena emerged at different computational stages. …

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