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Articles 1321 - 1350 of 10784
Full-Text Articles in Entire DC Network
Physiological Role And Mechanisms Of Action For A Long Noncoding Haplotype Region., Hong Xue, Manoj K Mishra, Yong Liu, Pengyuan Liu, Michael Grzybowski, Rajan Pandey, Kristie Usa, Mark A Vanden Avond, Niharika Bala, Abdel A Alli, Allen W Cowley, Qiongzi Qiu, Andrew S Greene, Sridhar Rao, Caitlin C O'Meara, Aron M Geurts, Mingyu Liang
Physiological Role And Mechanisms Of Action For A Long Noncoding Haplotype Region., Hong Xue, Manoj K Mishra, Yong Liu, Pengyuan Liu, Michael Grzybowski, Rajan Pandey, Kristie Usa, Mark A Vanden Avond, Niharika Bala, Abdel A Alli, Allen W Cowley, Qiongzi Qiu, Andrew S Greene, Sridhar Rao, Caitlin C O'Meara, Aron M Geurts, Mingyu Liang
Faculty Research 2025
Direct targeting of noncoding genomic regions harboring common sequence variants associated with human traits through in vivo animal model studies and precise genome editing in human cells is essential for closing the critical gap between genetic discoveries and physiological understanding. However, such investigation has been impractical for many of these variants as they are in haplotypes containing multiple single-nucleotide polymorphisms (SNPs) spanning thousands of base pairs and have small effect sizes. We developed an integrated approach to address this challenge, combining an efficient two-step technique to precisely edit large haplotypes in human induced pluripotent stem cells and orthologous region deletion …
Cholesterol Metabolism Regulated By Camkk2-Creb Signaling Promotes Castration-Resistant Prostate Cancer, Chenchu Lin, Thomas L Pulliam, Jenny J Han, Jiaqian Xu, Carlos Vera Recio, Sandi R Wilkenfeld, Yan Shi, Manoj Kushwaha, Sarah Bench, Eduardo Ruiz, Sanjanaa Senthilkumar, Jayasurya Dileep, Peter D A Shepherd, Nora M Navone, Albert R Klekers, Elizabeth M Whitley, Michael M Ittmann, Livia S Eberlin, Wenyi Wang, Daniel E Frigo
Cholesterol Metabolism Regulated By Camkk2-Creb Signaling Promotes Castration-Resistant Prostate Cancer, Chenchu Lin, Thomas L Pulliam, Jenny J Han, Jiaqian Xu, Carlos Vera Recio, Sandi R Wilkenfeld, Yan Shi, Manoj Kushwaha, Sarah Bench, Eduardo Ruiz, Sanjanaa Senthilkumar, Jayasurya Dileep, Peter D A Shepherd, Nora M Navone, Albert R Klekers, Elizabeth M Whitley, Michael M Ittmann, Livia S Eberlin, Wenyi Wang, Daniel E Frigo
Faculty, Staff and Student Publications
Castration-resistant prostate cancer (CRPC) remains an incurable disease in need of improved treatments. CAMKK2 is an emerging therapeutic target whose oncogenic effects in prostate cancer have, to date, been largely attributed to its activation of AMP-activated protein kinase (AMPK). Here, we demonstrate that CAMKK2 promotes prostate cancer growth through an alternative downstream pathway involving CAMKI and CREB. Unbiased transcriptomics identify CREB-mediated transcription as a CAMKK2-regulated process, findings that we validate using diverse molecular, genetic, and pharmacological approaches in vitro and in vivo. CAMKK2 promotes CREB phosphorylation/activation through CAMKIα independently of AMPK, CAMKIV, or other CAMKI isoforms. Functionally, the CREB family …
Apolipoprotein M Attenuates Age-Related Macular Degeneration Phenotypes Via Sphingosine-1-Phosphate Signaling And Lysosomal Lipid Catabolism, Tae Jun Lee, Andrea Santeford, Kristen M Pitts, Carla Valenzuela Ripoll, Ryo Terao, Zhen Guo, Mualla Ozcan, Dagmar Kratky, Christina Christoffersen, Ali Javaheri, Rajendra S Apte
Apolipoprotein M Attenuates Age-Related Macular Degeneration Phenotypes Via Sphingosine-1-Phosphate Signaling And Lysosomal Lipid Catabolism, Tae Jun Lee, Andrea Santeford, Kristen M Pitts, Carla Valenzuela Ripoll, Ryo Terao, Zhen Guo, Mualla Ozcan, Dagmar Kratky, Christina Christoffersen, Ali Javaheri, Rajendra S Apte
2020-Current year OA Pubs
Age-related macular degeneration (AMD) is a leading cause of blindness in people over 50. AMD and cardiovascular disease share risk factors including age, impaired lipid metabolism, and extracellular lipid deposition. Because of its importance in age-related diseases, we hypothesize that apolipoprotein M (ApoM), a lipocalin that binds sphingosine-1-phosphate (S1P), might restore lipid homeostasis and retinal function in AMD. In support, we find that human patients with AMD demonstrate significantly reduced ApoM compared to controls. In mice with impaired retinal cholesterol efflux, ApoM improves retinal pigment epithelium (RPE) function and lipotoxicity in an S1P- and S1P receptor 3-dependent manner. Ultrastructural evidence …
Protocol For Assessing Mobilization Of Peritoneal B Cells To The Pre-Metastatic Omentum In An Orthotopic Mouse Model Of Ovarian Cancer, Wonjae Lee, Hironari Akasaka, Honami Naora
Protocol For Assessing Mobilization Of Peritoneal B Cells To The Pre-Metastatic Omentum In An Orthotopic Mouse Model Of Ovarian Cancer, Wonjae Lee, Hironari Akasaka, Honami Naora
Faculty, Staff and Student Publications
The omentum is a visceral adipose tissue that undergoes dynamic immunological changes prior to and following metastasis. Here, we present a protocol for assessing the mobilization of peritoneal B cells to the pre-metastatic omentum in a mouse ovarian cancer model. We describe steps for isolation and adoptive transfer of peritoneal donor B cells and their detection in the omentum of recipient mice. This protocol could be utilized to study the mobilization of peritoneal B cells to the omentum in other pathological contexts. For complete details on the use and execution of this protocol, please refer to Lee et al.
Monoclonal Antibodies Targeting The Fimh Adhesin Protect Against Uropathogenic E. Coli Uti, Edward D B Lopatto, Jesús M Santiago-Borges, Denise A Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W Timm, Isabella F Fox, Aaron J Schmitz, Jackson S Turner, Shaza M Sayed Ahmed, Lillian Ortinau, Nathaniel C Gualberto, Jerome S Pinkner, Karen W Dodson, Ali H Ellebedy, Andrew L Kau, Scott J Hultgren
Monoclonal Antibodies Targeting The Fimh Adhesin Protect Against Uropathogenic E. Coli Uti, Edward D B Lopatto, Jesús M Santiago-Borges, Denise A Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W Timm, Isabella F Fox, Aaron J Schmitz, Jackson S Turner, Shaza M Sayed Ahmed, Lillian Ortinau, Nathaniel C Gualberto, Jerome S Pinkner, Karen W Dodson, Ali H Ellebedy, Andrew L Kau, Scott J Hultgren
2020-Current year OA Pubs
As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the health care system, increasing the need for alternative antibiotic-sparing treatments. Most UTIs are caused by uropathogenic
Elucidating Brain Transport Pathways And Cell Type-Dependent Gene Silencing Of A Durable Lipid-Sirna Conjugate Administered Into Cerebrospinal Fluid, Alexander G Sorets, Kathleen M Schoch, Timothy M Miller, Et Al.
Elucidating Brain Transport Pathways And Cell Type-Dependent Gene Silencing Of A Durable Lipid-Sirna Conjugate Administered Into Cerebrospinal Fluid, Alexander G Sorets, Kathleen M Schoch, Timothy M Miller, Et Al.
2020-Current year OA Pubs
The clinical neurosciences are in the midst of a renaissance spurred by the development of new therapeutic modalities. Short interfering RNAs (siRNAs), in particular, are gaining interest for treating neurological diseases owing to their capacity to sustain inhibition of nearly any gene target. However, to be effective, siRNA therapies must achieve delivery and on-target gene silencing activity in specific sites and cells in the brain. To this end, we developed a lipid-siRNA conjugate (L2-siRNA) that transports effectively throughout the brain when injected into cerebrospinal fluid (CSF). We provide a detailed examination of regional bulk tissue gene silencing in mice, highlighting …
Review: The Great Fuzz Frenzy, Rachel Schwedt
Review: The Great Fuzz Frenzy, Rachel Schwedt
Ages 7-9
Boldness, Community, Competition, Cooperation, Courage, Duty, Gratitude, Leadership, Survival, Trustworthiness
Review: Great Joy, Rachel Schwedt
Review: Great Joy, Rachel Schwedt
Ages 7-9
Caring, Friendliness, Generosity, Inquisitiveness, Inspiration, Joyfulness, Kindness, Sharing
Review: Francine Poulet Meets The Ghost Raccoon, Rachel Schwedt
Review: Francine Poulet Meets The Ghost Raccoon, Rachel Schwedt
Ages 7-9
Courage, Cooperation, Cooperation, Fear, Humor, Pride, Respect, Responsibility, Fear, Humor, Pride, Respect, Responsibility
Review: Babe: The Gallant Pig, Rachel Schwedt
Review: Babe: The Gallant Pig, Rachel Schwedt
Ages 7-9
Caring, Courage, Responsibility
Review: A Boy Called Bat, Rachel Schwedt
Review: A Boy Called Bat, Rachel Schwedt
Ages 7-9
Respect, Responsibility, Trustworthiness
Review: Whittington, Rachel Schwedt, Janice Delong
Review: Whittington, Rachel Schwedt, Janice Delong
Ages 10-12
Caring, Community, Compassion, Cooperation, Coping, Courage, Determination, Empathy, Encouragement, Faithfulness, Fear, Family loyalty, Friendship, Hope, Inspiration, Manners, Obedience, Persistence, Pride, Resolve, Respect, Self-control, Understanding, Work ethic
Review: Urchin Of The Riding Stars, Janice Delong, Rachel Schwedt
Review: Urchin Of The Riding Stars, Janice Delong, Rachel Schwedt
Ages 10-12
Ambition, Citizenship, Courage, Cooperation, Dependability, Devotion, Diversity, Faith, Fearlessness, Greed, Hope, Initiative, Inspiration, Jealousy, Pride, Respect, Responsibility, Spunk, steadfastness, Survival (physical), Trust, Trustworthiness
Review: The Talking Earth, Janice Delong, Rachel Schwedt
Review: The Talking Earth, Janice Delong, Rachel Schwedt
Ages 10-12
Appreciation of nature, Citizenship, Cleverness, Confidence, Coping, Courage, Craftsmanship, Creativity, Cunning, Curiosity, Dignity, Discernment, Diversity, Ethnic pride, Fear, Friendliness, Independence, Initiative, Kindness, Knowledge, Maturity, Obedience, Persistence, Perseverance, Resilience, Resourcefulness, Respect, Responsibility, Self-reliance, Self-respect, Sharing, Spunk, Strength, Survival (physical), Understanding, Wisdom, Work ethic
Review: The Iron, Janice Delong, Rachel Schwedt
Review: The Iron, Janice Delong, Rachel Schwedt
Ages 10-12
Caring, Citizenship, Cooperation, Coping, Courage, Determination, Dignity, Duty, Endurance, Fear, Greed, Honesty, Honor, Humility, Inspiration, Joyfulness, Knowledge, Leadership, Love, Loyalty, Maturity, Patience, Perseverance, Resilience, Respect, Responsibility, Selflessness, Self-control, Self-respect, Tolerance, Wisdom, Work ethic
Review: The Green Ember, Janice Delong, Rachel Schwedt
Review: The Green Ember, Janice Delong, Rachel Schwedt
Ages 10-12
Acceptance, Boldness, Citizenship, Cleverness, Community, Confidence, Courage, Craftsmanship, Dependability, Determination, Devotion, Discernment, Discipline, Diversity, Duty, Encouragement, Endurance, Faith, Fear, Forgiveness, Friendship, Hope, Imagination, Individuality, Inspiration, Leadership, Love, Obedience, Passion, Patriotism, Pride, Resolve, Resourcefulness, Respect, Responsibility, Spunk, Steadfastness, Survival (Physical), Trust, Trustworthiness, Wisdom
Review: The Boy Who Drew Birds: A Story Of John James Audubon, Janice Delong, Rachel Schwedt
Review: The Boy Who Drew Birds: A Story Of John James Audubon, Janice Delong, Rachel Schwedt
Ages 10-12
Appreciation of nature, Cleverness, Creativity, Curiosity, Dedication, Devotion, Independence, Initiative, Inquisitiveness, Joyfulness, Knowledge, Originality, Patience, Persistence, Resolve, Resourcefulness, Respect, Self-reliance, Steadfastness, Trust, Understanding, Wisdom, Wonder, Work ethic
Review: The Animal Book: A Collection Of The Fastest, Fiercest, Toughest, Cleverest, Shyest, And Most Surprising Animals On Earth, Janice Delong, Rachel Schwedt
Review: The Animal Book: A Collection Of The Fastest, Fiercest, Toughest, Cleverest, Shyest, And Most Surprising Animals On Earth, Janice Delong, Rachel Schwedt
Ages 10-12
Cleverness, Creativity, Imagination, Knowledge
Review: The Book Of Three, Janice Delong, Rachel Schwedt
Review: The Book Of Three, Janice Delong, Rachel Schwedt
Ages 10-12
Cooperation, Coping, Courage, Dependability, Determination, Devotion, Diversity, Duty, Endurance, Fear, Fearlessness, Friendship, Gratitude, Hope, Humor, Imagination, Joyfulness, Kindness, Leadership, Maturity, Obedience, Persistence, Pride, Resilience, Resolve, Respect, Responsibility, Sacrifice, Sharing, Spunk, Strength, Trust, Trustworthiness, Unselfishness, Wisdom
Review: Stickteen: John Muir And The Brave Little Dog, Janice Delong, Rachel Schwedt
Review: Stickteen: John Muir And The Brave Little Dog, Janice Delong, Rachel Schwedt
Ages 10-12
Confidence, Cooperation, Courage, Determination, Diligence, Encouragement, Endurance, Enthusiasm, Fear, Fearlessness, Friendship, Hope, Intuition, Joyfulness, Knowledge, Obedience, Passion, Perseverance, Resolve, Respect, Responsibility, Spunk, Survival (Physical), Trust, Wonder, Work ethic
Review: Rain Reign, Janice Delong, Rachel Schwedt
Review: Rain Reign, Janice Delong, Rachel Schwedt
Ages 10-12
Caring, Coping, Determination, Encouragement, Fear, Family love, Generosity, Hope, Kindness, Knowledge, Patience, Responsibility, Understanding
Review: Project Mulberry, Janice Delong, Rachel Schwedt
Review: Project Mulberry, Janice Delong, Rachel Schwedt
Ages 10-12
Appreciation of Nature, Competitiveness, Cooperation, Coping, Creativity, Curiosity, Dependability, Determination, Devotion, Diligence, Diversity, Enthusiasm, Forgiveness, Friendship, Ingenuity, Initiative, Neighborliness, Obedience, Patience, Respect, Responsibility, Sharing, Trust, Work ethic
Review: Owls In The Family, Janice Delong, Rachel Schwedt
Review: Owls In The Family, Janice Delong, Rachel Schwedt
Ages 10-12
Enthusiasm, Friendship, Ingenuity, Knowledge, Resourcefulness, Responsibility, Self-reliance, Sharing, Trustworthiness, Work ethic
Review: My Side Of The Mountain, Janice Schwedt, Rachel Schwedt
Review: My Side Of The Mountain, Janice Schwedt, Rachel Schwedt
Ages 10-12
Appreciation of nature, Cleverness, Courage, Craftsmanship, Creativity, Curiosity, Determination, Diligence, Endurance, Enthusiasm, Fear, Flexibility, Family love, Friendship, Humor, Independence, Individuality, Ingenuity, Initiative, Inquisitiveness, Knowledge, Originality, Persistence, Pride, Resolve, Resourcefulness, Self-respect, Spunk, Steadfastness, Thrift, Wisdom, Work ethic
Review: Dillon, Dillon, Rachel Schwedt, Janice Delong
Review: Dillon, Dillon, Rachel Schwedt, Janice Delong
Ages 10-12
Appreciation of nature, Caring, Coping, Independence, Inspiration, Patience, Respect, Responsibility, Self-acceptance, Steadfastness, Understanding, Wonder
Review: Cartwheeling In Thunderstorms, Janice Delong, Rachel Schwedt
Review: Cartwheeling In Thunderstorms, Janice Delong, Rachel Schwedt
Ages 10-12
Acceptance, Contentment, Courage, Determination, Diversity, Endurance, Fear, Friendship, Honesty, Initiative, Kindness, Resilience, Resolve, Self-reliance, Self-respect, Spunk, Tolerance, Wisdom
Fur, Fins, And Feathers: Abraham Dee Barlett And The Invention Of The Modern Zoo, Rachel Schwedt, Janice Delong
Fur, Fins, And Feathers: Abraham Dee Barlett And The Invention Of The Modern Zoo, Rachel Schwedt, Janice Delong
Ages 3-6
Citizenship, Caring, Dedication, Devotion, Enthusiasm, Leadership, Unselfishness
Fire On The Mountain, Rachel Schwedt, Janice Delong
Fire On The Mountain, Rachel Schwedt, Janice Delong
Ages 3-6
Fairness, Ambition, Cleverness, Courage, Endurance, Honesty, Humilty, Resourcefulness, Resolve, Wisdom
Integrating Endocannabinoid Signaling, Cck Interneurons, And Hippocampal Circuit Dynamics In Behaving Animals, Shreya Malhotra, Florian Donneger, Jordan S Farrell, Barna Dudok, Attila Losonczy, Ivan Soltesz
Integrating Endocannabinoid Signaling, Cck Interneurons, And Hippocampal Circuit Dynamics In Behaving Animals, Shreya Malhotra, Florian Donneger, Jordan S Farrell, Barna Dudok, Attila Losonczy, Ivan Soltesz
Faculty, Staff and Students Publications
The brain's endocannabinoid signaling system modulates a diverse range of physiological phenomena and is also involved in various psychiatric and neurological disorders. The basic components of the molecular machinery underlying endocannabinoid-mediated synaptic signaling have been known for decades. However, limitations associated with the short-lived nature of endocannabinoid lipid signals had made it challenging to determine the spatiotemporal specificity and dynamics of endocannabinoid signaling in vivo. Here, we discuss how novel technologies have recently enabled unprecedented insights into endocannabinoid signaling taking place at specific synapses in behaving animals. In this review, we primarily focus on cannabinoid-sensitive inhibition in the hippocampus in …
Btp2 Restricts Tulane Virus And Human Norovirus Replication Independent Of Store-Operated Calcium Entry, Francesca J Scribano, J Thomas Gebert, Kristen A Engevik, Nicole M Hayes, Jorge Villanueva, Son Pham, Soni Kaundal, Janam J Dave, B V Venkataram Prasad, Mary K Estes, Sasirekha Ramani, Joseph M Hyser
Btp2 Restricts Tulane Virus And Human Norovirus Replication Independent Of Store-Operated Calcium Entry, Francesca J Scribano, J Thomas Gebert, Kristen A Engevik, Nicole M Hayes, Jorge Villanueva, Son Pham, Soni Kaundal, Janam J Dave, B V Venkataram Prasad, Mary K Estes, Sasirekha Ramani, Joseph M Hyser
Faculty, Staff and Students Publications
Human norovirus is the leading cause of viral gastroenteritis across all age groups. While there is a need for human norovirus antivirals, therapeutic development has been hindered by a lack of cell culture systems and animal models of infection. Surrogate viruses, such as Tulane virus (TV), have provided tractable systems to screen potential antiviral compounds. Our previous work demonstrated that TV encodes a viral ion channel, which dysregulates cytosolic calcium signaling. We set out to investigate whether host pathways triggered by viral ion channel activity, including store-operated calcium entry (SOCE), play a role in virus replication. Using pharmacologic inhibitors and …