Digital Commons Network^™

Sleep And Aging: Challenges And Recommendations For Middle-Aged And Older Adults, Quinn M. Pearson

Adultspan Journal

No abstract provided.

Csf Protein Changes Associated With Hippocampal Sclerosis Risk Gene Variants Highlight Impact Of Grn/Pgrn, David W. Fardo, Yuriko Katsumata, John S. K. Kauwe, Yuetiva Deming, Oscar Harari, Carlos Cruchaga, Alzheimer’S Disease Neuroimaging Initiative, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Objective—Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNPs).

Methods—Alzheimer’s Disease Neuroimaging Initiative cohort (ADNI; n=237) data, combining both multiplexed proteomics CSF and genotype data, were used to assess the association between CSF analytes and risk SNPs in four genes (SNPs): GRN (rs5848), TMEM106B (rs1990622), ABCC9 (rs704180), and KCNMB2 (rs9637454). For controls, non-HS-Aging SNPs in APOE (rs429358/rs7412) and MAPT (rs8070723) were also analyzed against Aβ1-42 and total tau CSF analytes.

Results—The GRN risk …

Expand Paid Family And Medical Leave, Ernest Gonzales, Nancy Morrow-Howell, Huy Ho

Center for Social Development Research

This policy action statement was developed by members of the network engaged in the Grand Challenge to Advance Long and Productive Lives. The Grand Challenges initiative’s policy action statements present proposals emerging from Social Innovation for America’s Renewal, a policy conference organized by the Center for Social Development at Washington University in collaboration with theAmerican Academy of Social Work & Social Welfare, which is leading the Grand Challenges for Social Work initiative to champion social progress through a national agenda powered by science.

Neighborhood Environment And Falls Among Community-Dwelling Older Adults, Emily Nicklett, Matthew Lohman, Matthew Smith

Dartmouth Scholarship

Falls present a major challenge to active aging, but the relationship between neighborhood factors and falls is poorly understood. This study examined the relationship between fall events and neighborhood factors, including neighborhood social cohesion (sense of belonging, trust, friendliness, and helpfulness) and physical environment (vandalism/graffiti, rubbish, vacant/deserted houses, and perceived safety walking home at night).

Are My Memory Changes Normal?, Maria Norton, Elizabeth B. Fauth

All Current Publications

This fact sheet discusses memory changes. As we age, our brains age right along with the rest of our bodies. Our reaction time may begin to slow as a result of aging, and we will continue to experience “mild forgetfulness” as a normal part of life. If your memory changes are greater, or these changes seem to be noticeably impacting your ability to carry on your normal day-to-day activities, these are indicators that it is time to be evaluated by a physician for MCI, dementia, or other cognitive problems. An accurate diagnosis of dementia will help you and your physician …

Guide To Ms637 Amelia Mendez Castillo Papers, Andres Lucero

Finding Aids

Born in 1934, Amelia (Amy) Mendez Castillo was a social worker in El Paso. Her papers date 1964 – 2009, bulk 1970s – 1990s. Types of records include publications, correspondence, reports, photographs, and notes. The papers help document Castillo’s activities as a social worker.

Motor Timing Intraindividual Variability In Amnestic Mild Cognitive Impairment And Cognitively Intact Elders At Genetic Risk For Alzheimer’S Disease, Christina D. Kay, Michael Seidenberg, Sally Durgerian, Kristy A. Nielson, J. Carson Smith, John L. Woodard, Stephen M. Rao

Psychology Faculty Research and Publications

Introduction: Intraindividual variability (IIV) in motor performance has been shown to predict future cognitive decline. The apolipoprotein E-epsilon 4 (APOE-ε4) allele is also a well-established risk factor for memory decline. Here, we present novel findings examining the influence of the APOE-ε4 allele on the performance of asymptomatic healthy elders in comparison to individuals with amnestic MCI (aMCI) on a fine motor synchronization, paced finger-tapping task (PFTT).

Method: Two Alzheimer’s disease (AD) risk groups, individuals with aMCI (n = 24) and cognitively intact APOE-ε4 carriers (n = 41), and a control group consisting of cognitively intact APOE-ε4 noncarriers ( …

A Comparison Of Physical Nursing Home Environment For Older Adults And Their Families, Phatt Thaitrong

All Graduate Theses, Dissertations, and Other Capstone Projects

Globally, aging populations and increases in chronic diseases mean that more people will need long-term care in the next decade. Providing appropriate care to meet the needs of older adults and their families is a key consideration. This move to create a home-like environment in nursing homes has become extensive this past decade. Having an appropriate atmosphere where residents feel like they belong can help elderly people to age healthfully. This systematic literature analysis will address older adult residents' and their families' needs for nursing home physical environments and identify key elements of the physical nursing home environment for older …

The Romantic Baby Boomer: A Successful Aging Analysis Of Romantic Comedy Film Trailers, Annette Marie Schelling Masterson

Theses - ALL

On any given Friday night, theaters across the United States are filled with teenagers and young adults, often to see the new Blockbuster that has just been released. The film industry has responded by producing content specifically targeted to this demographic. Unfortunately, this has left a major portion of the population waiting for material that is relatable. Even when there is a character over the age of 50, they are regularly for comic relief or portrayed as weak and incapable. The recent trend of romantic comedies incorporating storylines for older adults is still underrepresented in academic research. This thesis set …

Reliability And Minimum Detectable Change For Common Clinical Physical Function Tests In Sarcopenic Men And Women, Nathaniel D.M. Jenkins, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: To determine the test–retest reliability and minimum detectable change scores for seven common clinical measurements of muscle strength and physical function in a multiethnic sample of sarcopenic, malnourished men and women.

Design: Each participant visited the laboratory seven times over 25 to 26 weeks. Reliability was assessed for each measurement from Familiarization 1 to Familiarization 2 (R1), Familiarization 2 to baseline testing (R2), Familiarization 3 to 12-week testing (R3), and Familiarization 4 to 24-week testing (R4).

Setting: Data were collected during a clinical trial at 23 sites in the United States, Belgium, Italy, Mexico, Poland, Spain, Switzerland, and the …

Establishing Biological Plausibility For Cognitive Frailty, Lana Jean Sargent

MUSC Theses and Dissertations

Cognitive frailty is considered a potentially reversible age-related condition characterized by the simultaneous presence of both physical frailty and cognitive decline. The concept of cognitive frailty existing in older adults is indisputable, although the mechanisms and the directional relationship behind the dynamic association remain unexplained. Mechanisms have been suggested, often linking cognitive frailty to cognitive impairment or as a component of frailty but without an understanding of the biological bases for these associations we cannot not move forward with intervention trials. This dissertation examines the biological mechanisms for cognitive frailty. The study is the first to use a large number …

Integrative Care Models: Impact On An Aging Society Chelsea Rink, Chelsea Rink

SPNHA Review

This paper explores the need for healthcare reform to support the aging population in the United States. In the literature review, the author identifies the unique needs of the aging population and explores the application of integrated care models in achieving the healthcare Triple Aim. Two alternative integrated care models for older adults in the United States are examined: the Program of All-Inclusive Care for the Elderly (PACE) and Tandem 365. Berwick, Nolan, and Whittington’s (2008) recommendations of key framework for integrated care models to achieve the Triple Aim are introduced and utilized to evaluate and compare PACE and Tandem …

Aging Is In The Eye Of The Beholder: Eye-Tracking And Person-Perception Analyses Of Young And Old Faces, Stephanie M. Ha

Honors Theses

To examine possible mechanisms related to negative attitudes of aging revealed in face processing patterns, young and old participants rated their first impressions (positive or negative) of 100 faces of young and old individuals taken from the CAL/PAL Fate Database (Minear & Park, 2004) while gaze patterns were recorded using eye-tracking methods. In a follow-up study, an independent sample of young participants rated the same 100 faces on competence, attractiveness, and subjective age in order to further assess age-related stereotypes. This study replicated the T-gaze pattern in previous eye-tracking studies (Firestone, Turk, Browne, & Ryan 2007). We also found evidence …

The Relationship Between Physical Fitness And Falling Risk And Fear Of Falling Incommunity-Dwelling Elderly People With Different Physical Activity Levels, Mehmet Duray, Arzu Genç

Turkish Journal of Medical Sciences

Background/aim: The aim of this research was to determine the effects of physical activity level (PAL) and physical fitness on falling parameters in community-dwelling elderly people. Materials and methods: Seventy-six elderly people were grouped as low PAL group (group 1, n: 38) and high PAL (group 2, n: 38) according to their PAL scores. PAL was measured by the Physical Activity Scale for the Elderly and muscle strength, muscle endurance, aerobic endurance, and flexibility tests were applied; body mass index (BMI) was calculated for physical fitness measurement. Fall assessment included falling risk (Berg Balance Scale), dynamic balance (Time Up and …

Insulin Actions On Hippocampal Neurons, Shaniya Maimaiti

Theses and Dissertations--Pharmacology and Nutritional Sciences

Aging is the main risk factor for cognitive decline. The hippocampus, a brain region critical for learning and memory formation, is especially vulnerable to normal and pathological age-related cognitive decline. Dysregulation of both insulin and intracellular Ca2+ signaling appear to coexist and their compromised actions may synergistically contribute to neuronal dysfunction with aging. This dissertation focused on the interaction between insulin, Ca2+ dysregulation, and cognition in hippocampal neurons by examining the contributions of insulin to Ca2+ signaling events that influence memory formation. I tested the hypothesis that insulin would increase cognition in aged animals by altering Ca2+-dependent physiological mechanisms involved …

Moderate-Load Muscular Endurance Strength Training Did Not Improve Peak Power Or Functional Capacity In Older Men And Women, Simon J. Walker, Greg G. Haff, Keijo K. Häkkinen, Robert U. Newton

Research outputs 2014 to 2021

The present study determined the effects of muscular endurance strength training on maximum strength and power, functional capacity, muscle activation and hypertrophy in older men and women. Eighty-one men and women acted as an intervention group while 22 acted as non-training controls (age range 64-75 y). Intervention training included super-sets (i.e., paired exercises, immediately performing the second exercises following completion of the first) with short rest intervals (30-60 s between sets) at an intensity of 50-60% one-repetition maximum (1-RM) for 15-20 repetitions. Concentric leg press actions measured maximum strength (1-RM) and concentric peak power. Functional capacity was assessed by maximum …

Race And Income Disparities In Disaster Preparedness In Old Age, Katherine M. Cox

Master's Theses and Capstones

Objective: Older adults are one of the most vulnerable populations impacted by disasters and communities continue to struggle addressing preparedness. This study investigated to what extent income status and race/ethnicity in old age interplayed with disaster preparedness.

Methods: Data came from the 2010 Health and Retirement Study, a nationally representative panel survey of older Americans over 51 years old. Our sample was restricted to respondents who participated in a special survey about disaster preparedness (N=1,705). Disaster preparedness was measured as a score, which includes 13 variables related to personal, household, program, and medical preparedness. Race/ethnicity was categorized by White, Black, …

Initial Findings Of A Medicare Annual Wellness Visit Program, Hesper B. Nowatzki

Walden Dissertations and Doctoral Studies

Despite the emphasis of benefits on preventive health, many older adults are not receiving the recommended age specific, evidence based screenings and vaccinations. The Medicare Annual Wellness Visit (AWV) is designed to address modifiable risk factors with aging adults and close gaps in care not captured in routine office visits. Although a free Medicare benefit to patients, and a reimbursable service to health care providers, participation in the AWV is low nationwide. The purpose of the project is to introduce an AWV program to a rural health clinic in Northwest Illinois that has a population consisting of over 25% of …

Using Pentosidine And Hydroxyproline To Predict Age And Sex In An Avian Species, Brian S. Dorr, Randal S. Stahl, Katie C. Hanson-Dorr, Carol A. Furcolow

United States Department of Agriculture Wildlife Services: Staff Publications

All living organisms are subject to senescence accompanied by progressive and irreversible physiological changes. The error damage and cross-linking theories suggest that cells and tissues are damaged by an accumulation of cross-linked proteins, slowing down bodily processes and resulting in aging. A major category of these cross-linked proteins are compounds called advanced glycation end products (AGEs). We investigated the relationship between accumulation of the AGE, pentosidine (Ps), and hydroxyproline (HYP) a post-translationally modified amino acid, with age, sex, and breeding status (breeder/ nonbreeder) from skin samples of known age (i.e., banded as fledglings), free-ranging Double-crested Cormorants (Phalacrocorax auritus, …

Cognitive Correlates Of Driving Behavior In Older Adults With Hiv, Caitlin Northcutt Pope

All ETDs from UAB

Human immunodeficiency virus (HIV) currently affects over 1 million individuals in the United States. It is estimated that by the year 2020, up to 70% of individuals with HIV in the United States will be ages 50 and older, as these individuals live longer due to more advanced medicine and later diagnosis. Aging research suggests individuals with HIV may be at risk for accelerated or accentuated aging making age-related deficits, particularly with cognition and everyday functioning, of public concern. The current study investigated the complex associations between age, HIV disease state, cognition, health, and driving in 139 older adults (Mage …

An Examination Of The Neuropsychological Construct Executive Function And How It May Be Impacted By Cognitive And Exercise Interventions, Erica Schmidt

All ETDs from UAB

Background: There is a growing body of literature supporting the beneficial effects of cognitive training and exercise training on executive function (EF) in older adults. More recently, evidence is amassing that interventions which combine cognitive and physical activity, for example, exergames, may confer even greater cognitive benefits. Comparison of EF interventions for older adults requires more investigation and would benefit from improved operationalization of the EF construct and better understanding of factors which predict baseline EF in older adults. Methods and Results: Fifty-seven sedentary, non-gamer, community dwelling older adults were randomly assigned to one of three intervention groups (computerized cognitive …

Age Differences In Dynamic Fatigability And Variability Of Arm And Leg Muscles: Associations With Physical Function, Jonathon Senefeld, Tejin Yoon, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Introduction

It is not known whether the age-related increase in fatigability of fast dynamic contractions in lower limb muscles also occurs in upper limb muscles. We compared age-related fatigability and variability of maximal-effort repeated dynamic contractions in the knee extensor and elbow flexor muscles; and determined associations between fatigability, variability of velocity between contractions and functional performance.

Methods

35 young (16 males; 21.0 ± 2.6 years) and 32 old (18 males; 71.3 ± 6.2 years) adults performed a dynamic fatiguing task involving 90 maximal-effort, fast, concentric, isotonic contractions (1 contraction/3 s) with a load equivalent to 20% maximal voluntary isometric …

Gomds - Grumpy Old Men Doing Shakespeare; The Comedy Of Errors As Metaphor For Life, Aging, And Building Community, Elizabeth B. Pedersen

Theses and Dissertations

This thesis explores the process of building community over time, through collaboration, to rehearse and produce a portable production of Shakespeare's The Comedy of Errors, looking at the elements of time, trust and age with an ensemble of ten men, all actors over the age of 55. The building of trust over time was vital to the production process and the actors had the time to embody their roles and the language of the play. We look at the questions “why this play,” “why all men?” and “why theatre?” and investigate the physical nature of the play and its …

Narrative Review Of Vitamin D And Its Specific Impact On Balance Capacity In Older Adults, Ray Marks

Publications and Research

Introduction and Aims: Falls injuries among older adults, a widespread well-established contributor to high disability levels, excess morbidity and mortality rates, have many causes. This review examines the association between vitamin D levels and postural stability or balance control—a fairly consistent predictor of falls among older adults.

Materials and Method: All relevant English language peer reviewed research publications detailing the relationship between vitamin D levels and balance control among the elderly were sought. Key words included “Vitamin D and Balance or Postural Control.” Databases used were Academic Search Complete, PubMed, Scopus, and Web of Science.

Results: Analysis showed no consistent …

Development, Validation And Application Of A New Fornix Template For Studies Of Aging And Preclinical Alzheimer's Disease, Christopher A. Brown, Nathan F. Johnson, Amelia J. Anderson-Mooney, Gregory A. Jicha, Leslie M. Shaw, John Q. Trojanowski, Linda J. Van Eldik, Frederick A. Schmitt, Charles D. Smith, Brian T. Gold

Physical Therapy Faculty Publications

We developed a merged younger-older adult template of the fornix and demonstrated its utility for studies of aging and preclinical Alzheimer's disease (AD). In Experiment 1, probabilistic tractography was used to reconstruct the fornix in younger and older adults and successful streamlines were then averaged to create a merged template in standard space. The new template includes the majority of the fornix from the hippocampal formation to the subcallosal region and the thalamus/hypothalamus. In Experiment 2, the merged template was validated as an appropriate measure for studies of aging, with comparisons against manual tracing measures indicating identical spatial coverage in …

Salem For All Ages: An Age-Friendly Action Plan, Caitlin E. Coyle, Jan Mutchler

Center for Social and Demographic Research on Aging Publications

The City of Salem is dedicated to being an ideal place for people of all ages and abilities to live, work, learn and play. Towards this goal the City applied, and was accepted, to the World Health Organization’s Network of Age-Friendly Communities in 2015. Almost entirely directed by passionate resident leaders from Salem and with the support and enthusiasm of Mayor Kimberly Driscoll and participating City Departments, a series of activities were undertaken to assess the needs of Salem’s older adult population. In June 2016, the City of Salem invited collaboration from the Center for Social & Demographic Research on …

Psychological Stress Among Risks For Alzheimer's Disease, Maria C. Norton, Elizabeth B. Fauth

All Current Publications

This fact sheet defines stress, stressors and reaction to them, what stress does to our brain and body, and how stress effects can accumulate over time. It also includes tips on reducing the effects of stress on the brain.

Hiv And Aging: Global Implications For Social Care Of A Vulnerable Population, Mark Brennan-Ing

Aging Studies Institute

In the early 1980s when Human Immunodeficiency Virus (HIV), the cause Acquired Immune Deficiency Syndrome (AIDS), was first identified, life expectancy following diagnosis was approximately two years (Halkitis, 2013). With the advent of highly-active antiretroviral therapy (HAART) in the mid-1990s, life expectancy for people with HIV (PWH) increased sharply. PWH receiving HAART treatment shortly after diagnosis can now expect to live as long as uninfected individuals (van Sighem, Gras, Reiss, Brinkman, & de Wolf, 2010). As a result the population with HIV is aging. It is estimated that in 2015, 50% of PWH in the U.S. were age 50 and …

Examining The Interplay Between Spousal And Non-Spousal Social Support And Strain On Trajectories Of Functional Limitations Among Married Older Adults, Scott A. Adams

Department of Sociology: Dissertations, Theses, and Student Research

Marriage is a key social status related to the distribution of later life disablement. One factor within the marital relationship thought to be consequential for disablement is social support from the spouse. Nonetheless, marriage is not inherently supportive and may also be a source of chronic strain. According to the social support/stress model spousal social support is expected to result in better functional health outcomes while spousal strain is hypothesized to produce poorer functional health in later life. Beyond spousal support and strain, marriage is also embedded in a broader web of emotionally close non-spousal ties that are also likely …

Pubh 4231 - Health Aspects Of Aging, Jamie S. Cromley

College of Public Health: Faculty Syllabi (2014-2021)

This course is intended to familiarize students with promotion of health in an aging population, the notion that aging is a natural part of the lifecycle, community, state and federal health programs and services for the aged. Students will become acquainted with the process of and problems associated with aging in order to effectively manage this important public health issue. Specific health concerns of the elderly including the increase in life expectancy, current life extending research and technology and successful aging will also be examined. Knowledge and understanding of biological, psychological, and sociological aspects of aging as related to health …