Digital Commons Network^™

Intravenous Aviptadil And Remdesivir For Treatment Of Covid-19-Associated Hypoxaemic Respiratory Failure In The Usa (Tesico): A Randomised, Placebo-Controlled Trial, Samuel M Brown, Christina E Barkauskas, Birgit Grund, Shweta Sharma, Andrew N Phillips, Lindsay Leither, Ithan D Peltan, Michael Lanspa, Daniel L Gilstrap, Ahmad Mourad, Kathleen Lane, Jeremy R Beitler, Alexis L Serra, Ivan Garcia, Eyad Almasri, Mohamed Fayed, Kinsley Hubel, Estelle S Harris, Elizabeth A Middleton, Macy A G Barrios, Kusum S Mathews, Neha N Goel, Samuel Acquah, Jarrod Mosier, Cameron Hypes, Elizabeth Salvagio Campbell, Akram Khan, Catherine L Hough, Jennifer G Wilson, Joseph E Levitt, Abhijit Duggal, Siddharth Dugar, Andrew J Goodwin, Charles Terry, Peter Chen, Sam Torbati, Nithya Iyer, Uriel S Sandkovsky, Nicholas J Johnson, Bryce R H Robinson, Michael A Matthay, Neil R Aggarwal, Ivor S Douglas, Jonathan D Casey, Manuel Hache-Marliere, J Georges Youssef, William Nkemdirim, Brad Leshnower, Omar Awan, Sonal Pannu, Darragh Shane O'Mahony, Prasad Manian, J W Awori Hayanga, Glenn W Wortmann, Bruno M Tomazini, Robert F Miller, Jens-Ulrik Jensen, Daniel D Murray, Nina A Bickell, Jigna Zatakia, Sarah Burris, Elizabeth S Higgs, Ven Natarajan, Robin L Dewar, Adam Schechner, Nayon Kang, Alejandro Arenas-Pinto, Fleur Hudson, Adit A Ginde, Wesley H Self, Angela J Rogers, Cathryn F Oldmixon, Haley Morin, Adriana Sanchez, Amy C Weintrob, Alexandre Biasi Cavalcanti, Anne Davis-Karim, Nicole Engen, Eileen Denning, B Taylor Thompson, Annetine C Gelijns, Virginia Kan, Victoria J Davey, Jens D Lundgren, Abdel G Babiker, James D Neaton, H Clifford Lane

Faculty, Staff and Student Publications

BACKGROUND: There is a clinical need for therapeutics for COVID-19 patients with acute hypoxemic respiratory failure whose 60-day mortality remains at 30-50%. Aviptadil, a lung-protective neuropeptide, and remdesivir, a nucleotide prodrug of an adenosine analog, were compared with placebo among patients with COVID-19 acute hypoxaemic respiratory failure.

METHODS: TESICO was a randomised trial of aviptadil and remdesivir versus placebo at 28 sites in the USA. Hospitalised adult patients were eligible for the study if they had acute hypoxaemic respiratory failure due to confirmed SARS-CoV-2 infection and were within 4 days of the onset of respiratory failure. Participants could be randomly …

Greater Male Variability In Daily Energy Expenditure Develops Through Puberty, Lewis G Halsey, Vincent Careau, Philip N Ainslie, Heliodoro Alemán-Mateo, Lene F Andersen, Liam J Anderson, Leonore Arab, Issad Baddou, Linda Bandini, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Soren Brage, Maciej S Buchowski, Nancy Butte, Stephan G Camps, Regian Casper, Graeme L Close, Lisa H Colbert, Jamie A Cooper, Richard Cooper, Prasangi Dabare, Sai Krupa Das, Peter S W Davies, Sanjoy Deb, Christine Delisle Nyström, William Dietz, Lara R Dugas, Simon Eaton, Ulf Ekelund, Asmaa El Hamdouchi, Sonja Entringer, Terrence Forrester, Barry W Fudge, Melanie Gillingham, Annelies H Goris, Michael Gurven, Hinke Haisma, Catherine Hambly, Daniel Hoffman, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Wantanee Kriengsinyos, Rebecca Kuriyan, Robert F Kushner, Estelle V Lambert, Pulani Lanerolle, Christel L Larsson, Nader Lessan, Marie Löf, Corby Martin, Eric Matsiko, Gerwin A Meijer, James C Morehen, James P Morton, Aviva Must, Marian Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietilainen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto Rabinovich, Susan B Racette, David A Raichen, Eric Ravussin, Leanne Redman, John J Reilly, Rebecca Reynolds, Susan Roberts, Jennifer C Rood, Dulani Samaranayake, Luís B Sardinha, Albertine J Scuitt, Analiza M Silva, Srishti Sinha, Anders M Sjödin, Eric Stice, Albert Stunkard, Samuel S Urlacher, Mauro Eduardo Valencia, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jeanine A Verbunt, Jonathan C K Wells, George Wilson, Brian Wood, Tsukasa Yoshida, Xueying Zhang, Alexia Murphy-Alford, Cornelia Loechl, Amy Luke, Herman Pontzer, Jennifer Rood, Hiroyuki Sagayama, Klaas R Westerterp, William W Wong, Yosuke Yamada, John R Speakman

Faculty, Staff and Student Publications

There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at …

Cancer Patients' Preferences And Perceptions Of Advantages And Disadvantages Of Telehealth Visits During The Covid-19 Pandemic, Deepika Kumar, Nancy Gordon, Constanza Zamani, Tammy Sheehan, Ernesto Martin, Olga Egorova, Jessica Payne, Tatjana Kolevska, Elad Neeman, Raymond Liu

Faculty, Staff and Student Publications

PURPOSE: We aimed to ascertain oncology patients' perceptions of telehealth versus in-person (IP) visits for different types of clinical encounters.

METHODS: We surveyed adults undergoing cancer treatment at Kaiser Permanente Northern California infusion centers between November 2021 and May 2022 using a self-administered questionnaire. Patients were asked about visit modality preferences (video, phone, and IP) for six types of clinical discussions, overall advantages and disadvantages of telehealth (video or phone) versus IP modalities, and barriers to video visit use.

RESULTS: The 839 patients who completed surveys in English were 63% female; median age 63 years; 64% White; and 73% college-educated …

Low Pitch Significantly Reduces Helical Artifacts In Abdominal Ct, Moiz Ahmad, Peng Sun, Christine B Peterson, Marcus R Anderson, Xinming Liu, Ajaykumar C Morani, Corey T Jensen

Faculty, Staff and Student Publications

Purpose: High helical pitch scanning minimizes scan times in CT imaging, and thus also minimizes motion artifact and mis-synchronization with contrast bolus. However, high pitch produces helical artifacts that may adversely affect diagnostic image quality. This study aims to determine the severity and incidence of helical artifacts in abdominal CT imaging and their relation to the helical pitch scan parameter.

Methods: To obtain a dataset with varying pitch values, we used CT exam data both internal and external to our center. A cohort of 59 consecutive adult patients receiving an abdomen CT examination at our center with an accompanying prior …

Chronic Illness Education 2023: Workout Your Mind: How Exercise Can Help Fight Depression, Sarah Bdeir, Kevin Cobty, Dana Josifoski, Joyce Li, Sujit Prasad, Ahmad Khatib, Kishwar Basith

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Survey For Copd Risk Factors For Clinic Use, Saleh Al-Juburi, Alexa Kalaj, Amrutha Kotlure, Hannah Lee, Salvatore Serra, Juwan Taylor, Mirna Kaafarani

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: How To Promote Mental Wellness As Medical Students, Sneha Bhargava, Basel Mhaimeed, Demetrius Moncrease, Parshva Salvi, Marissa Yaldo, Fadumo Yusuf, Anna Kang

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Misconceptions Surrounding Adult Obesity With Targeted Educational Materials, Andrew Lemmen, Shrila Rajendran, Daniel Saxon, Devun Birk, Timothy Li, Pooja Polamarasetti

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Analyzing Effective And In-Effective Treatment Options For Physicians In Training With Anxiety And Depression., Sophia Gandarillas, Cyra Kharas, Robert Leone, Mihika Sridhar, Kishwar Basith

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Prevalence Of Anxiety In First And Second-Generation American Medical Students, Cyrus Amirfazli, Nina Brahmbhatt, Adam Chaban, Aminah Fayyaz, Karina Haleblian, Ajay Pradhan, Kishwar Basith

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Managing Cholesterol, Gabriella Gonzales, Leane Kuo, Tannia M. Rodriguez, Anah Nicolai, Mitchell Wu, Michelle Malik

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Deciphering Food Labels, Paige Awtrey, Jessica Elderkin, Hajirah Farah, Dylan Kato, Michael Salloum, Jack Visser, George Kidess

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Prevention And Treatment Of Cardiovascular Disease Amid Food Insecurity In Southeast Michigan, Kirsten Brinkmeier, John Gallagher, Hovhannes Hayrapetyan, Nasser Junedi, Julia Malewicz, Alisha Williams

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Healthy Heart Habits For Kids, Chase Aaron, Jane Dow, Max Jones, Karamoja Monchamp, Ingrid Rocha, Arhan Shetty, Kelsey Gockman

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Adult Obesity & Sedentary Lifestyle In Detroit, Lisa Doan, Kimera Harris, Cornelius Lau, Hani Nasr, Ciara White, Pooja Polamarasetti

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Increasing Nutritional Literacy For Adults Living With Type Ii Diabetes In Detroit, Mi, Morolayo Ilori, Katherine Gavagan, Izma Khaliq, Srikanth Pillai, Nabeel Sumbal, Derya Turk, Zechariah Jean

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Simplifying Treatment Options For Type Ii Diabetes Mellitus, Mura Abdul-Nabi, Lukas Biel, Nitya Deshpande, Melissa Elmali, Joseph Mccormick, Emily Smith, Matthew Corsi

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Diabetes Management In Arab American Communities With Middle Eastern Cuisine, Neeti Gandra, Uzair Khan, Christopher Rittle, Nora Sharba, Josiah Stryd, Gretchen Swift, Kinan Sawar

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Implications Of Uncontrolled Type Ii Diabetes On Healthspan And Strategies Of Prevention, Chanel Harvey, Brian Hughes, Neeraj Ochaney, Aalia Siddiqui, Anna Zhao, Anneliese Rademacher

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: A Comprehensive Survey To Follow-Up With Young Individuals Recently Diagnosed With Hiv, Brock Bradley, Pranally Desai, Nathan Li, Eve Sherbin, Jeremy Taigman, Zachary Vaishampayan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Five Easy Ways To Stick To Your Perinatal Hiv Treatment Plan, Simran Brar, Gabrielle Cowen, Anastasia Goldbaum, Austin Kim, Cole Sabinash, Kassim Salami, Zachary Vaishampayan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Don’T Be Salty About Ckd: How To Watch Your Sodium Intake, Anthony Bally, Sarah Chamdin, Yousif Jafar, Petar Martinovski, Manahil Shaikh, Nadeen Sukhon, Arnulfo Cazares

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Hiv Treatment Accessibility & Access To Clinics (Ages 18+) In Detroit, Brennan Burrows, Gabriella Cascio, Tiffany Chu, Samantha Odeesho, Sumeet Saini, Nickolas Vinokurov, Zachary Vaishampayan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Nontraditional Factors That Affect Blood Glucose: Things Diabetic Should Know, Hazem Alata, Rebecca Cameron, Desiree Duncan, Kyle O'Hollaren, Nicole Oska, Kyriacos Vlachos, Trey Vanaken

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Providing Resources For Wsusom Students Exhibiting Major Depressive Symptoms, Ece Erder, Zunaira Imran, Parsa Kamalipour, Deni Peterson, John Pum, Kishwar Basith

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Available Mental Health Resources For Students With Anxiety And Depression, Carline Dugue, Lauren Fleckenstein, Ethan Mathew, Alexander Minos, Katherine Sommers, Peter Zakaria, Anna Kang

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Glycemic Index And Diabetes, Michelle Chung, Olivia Decker, Nevil Khurana, Breanna Ramsey, Riley Wistrom, Sinyu Yang, Jacqueline Townshend

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Recognizing And Managing Anxiety And Depression In Medical Students, Angie Achkar, Brandon Doan, Abigail Jaczkowski, Julian Johnson, Diana Mcmahon, Kevin Tran, Anna Kang

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Healthy Living With Diabetes: How To Use And Understand Continuous Glucose Monitor (Cgm), Hussein Bazzi, Emma Breukink, Ranganath Kathawate, Ron Lukose, Vikram Rajan, Noor Sulaiman, Anneliese Rademacher

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: The Impact Of Food Deserts On Adult Diabetes Mellitus, Stephanie Barna, Blaise Deschamps, Jack Mao, Armaan Naghdi, Anjani Raja, Noor Sulieman, Anneliese Rademacher

Patient Education Projects

No abstract provided.