Digital Commons Network^™

Municipal Budgeting In Times Of Crisis: A Study Of Fiscal Conjunctures In Three U.S. Cities, Mark Davidson, Kevin Ward

Geography

Since the late 1950s and early 1960s, U.S. cities have been associated with various types of crises. Recent decades have been no exception, with the Global Financial Crisis (GFC) and COVID-19 pandemic being external events that severely disrupted U.S. urban fiscal governance. This disruption involves both the generation of new challenges (e.g., housing market declines, social distancing) and a worsening of longstanding urban challenges relating to, for example, housing, inequality, racism, segregation, and so on. This paper focuses on how the internal fiscal governance of three U.S. cities—Buffalo, Nashville, and San Jose—navigated the GFC and COVID-19 pandemic. We find that …

Quantum General Relativity V2, James Glimm, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

We construct a quantum general relativity theory.. The construction includes specification of a cosmological model. Based on type Ia supernova data, the model has zero dark energy and zero cosmological constant.

The analysis is at the level of theoretical physics, with some mathematical details omitted.

Mathematicly Rigorous Quantum General Relativity, I: Pure, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

A pure general relativity (quantum or classical) is one lacking in matter. Such a field has a Lorentzian space time geometry. A renormalization perturbative expansion, truncated to all finite orders, establishes both the quantum and the general relativity theory with full mathematical rigor.

Weak Solutions Of The Navier-Stokes Equation And Their Euler Limits, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

The existence of a weak solution of the incompressible isothermal Navier-Stokes equation with given initial conditions in the Sobolev space $\mathcal{H}_{-2}$ for energy fluctuations and in $\mathcal{H}_{-3}$ for enstrophy fluctuations is assumed. The existence is uniform with respect to the Euler limit of zero viscosity $\nu$. Thus, existence of weak solutions of the Euler equation with given initial conditions is established, and these Euler solutions are the zero viscosity limit of Navier-Stokes solutions, provided the Navier-Stokes solutions exist.

The Yang-Mills Field: The Fermion Sign Problem, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

A mathematical resolution of the Fermion sign problem is accomplished based on the theory of homology groups and thimbles. The original contribution of this paper is the mathematicly rigorous convergence of residual states. The residual states remain after use of a rigorous Picard-Lefschetz saddle point optimization.

The proofs depend on an assumed principle of a maximum rate of entropy production.

Two Yang-Mills gauge field theories are constructed, one based on short distance asymptotics and the other based on long distance asymptotics.

The Pure Yang-Mills Field. I: Eistence, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

Two pure Yang-Mills quantum gauge field theories are constructed, one based on short distance asymptotics and the other based on long distance asymptotics.

The construction is based on the axial gauge, ghost states, the BRST framework and Gribov extension of the Hamiltonian, with a loop expansion cutoff to all finite orders for the dynamics.

The construction is established by renormalized perturbation theory to all finite orders.

The construction depends on an assumed principle of a maximum rate of entropy production

The Pure Yang-Mills Field: The Mass Gap; Axioms Minus One, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

A strictly positive gap at low temperatures is demonstrated in the energy spectrum of the previously constructed pure Yang-Mills quantum gauge field theories. Axioms other than the cluster axiom are verified.

The Pure Yang-Mills Field, \, Iia: The Axioms, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

A previously constructed pure Yang-Mills quantum gauge field theory is shown to satisfy all Osterwalder Schrader axioms.

Non-Smooth Solutions Of The Navier-Stokes Equation And Their Means, James Glimm, Jarret Petrillo

Department of Applied Mathematics & Statistics Faculty Publications

Non-smooth (finite time blowup) Leray-Hopf solutions of the incompressible Navier-Stokes equation are constructed. The initial data for blowup is characterized by nonzero energy related turbulent fluctuations. The construction occurs in a finite periodic cube T3. The mean value of a weak solution of the Navier-Stokes equation is identified as a smooth solution of the Navier-Stokes equation.

General Relativity: Existence, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

A mathematically rigorous renormalized perturbative expansion, truncated to all finite orders, establishes the existence of quantum general relativity theories with Fermion matter fields. The expansion is initialized with the selection of a vacuum state.

Distinct infrared (IR) and ultraviolet (UV) vacuum states are considered. The IR vacuum state defines a cosmology model. The UV vacuum state defines a black hole model.

The vacuum state is initialized with a $\mathfrak{o}^3$ gauge Lie algebra defining a quark-gluon plasma. With this choice, string theory is avoided.

Finite order renormalized perturbation theory, defined using Bosons to avoid Fermion sign cancellation, is convergent to all …

The Pure Yang-Mills Field, Repeated Blowups, James Glimm, James G. Glimm

Department of Applied Mathematics & Statistics Faculty Publications

The temporal scaling of the quantum Yang-Mills solution is characterized by analytic solutions for a limited time interval, ended by a discontinuity (blowup).

For general initial conditions, there will be a finite series of these discontinuities.

The time asymptotic limit of this series of discontinuities is given as the mean of these solutions, starting with the mean of the initial data. The time asymptote is the solution in $\mathcal{S}'$ of the heat equation as a stochastic process.

The time asymptote satisfies the cluster axiom, to complete the requirements for a solution of the Millennium Yang-Mills problem.

The principle of a …

The Boson Yang-Mills Field: The Loop Expansion, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

This paper demonstrates convergence of the loop expansion for Yang-Mills fields.

The loop construction of perturbation theory is based on the axial gauge, ghost states, the BRST framework and the Gribov extension of the Hamiltonian, with the loop expansion perturbatively renormalizable.

The construction is established by renormalized perturbation theory convergent to all finite orders.

Two distinct Yang-Mills theories are constructed, one based on short distance asymptotics and the other based on long distance asymptotics.

The construction depends on an assumed principle of a maximum rate of entropy production.

The paper has sufficient generality to include existence for all cases that …

School-Level Gaps In Mmr Coverage As The Fuel For Measles Outbreaks, Meagan C Fitzpatrick, Chad R Wells, Abhishek Pandey, Lamia Ayaz, Peter J Hotez, Seyed M Moghadas, Alison P Galvani

Faculty, Staff and Students Publications

No abstract provided.

Evaluating Mesothelin As An Immunotherapeutic Target For Endogenous T Cells, Kiriakos Koukoulias, Ryu Yanagisawa, Alejandro G Torres Chavez, Penelope G Papayanni, Yovana Velazquez, Hyun-Sung Lee, Spyridoula Vasileiou, Ann M Leen

Faculty, Staff and Students Publications

Background: Mesothelin (MSLN) is a GPI-anchored cell surface glycoprotein that is overexpressed in various solid tumors, including mesothelioma, triple-negative breast cancer, colon, ovarian and pancreatic cancer, with restricted normal tissue expression.

Methods: To explore the immunogenicity and immunotherapeutic potential of MSLN to T cells with native receptor specificity, 29 individuals of diverse HLA backgrounds were interrogated for T cell activity against MSLN.

Results: Twenty one (72%) subjects (21/29) mounted a specific T cell response when repetitively challenged with MSLN antigen. Reactive cells were Th1-polarized, polyfunctional, predominantly detected in the CD8+ T cell compartment and cytotoxic toward autologous and MSLN+/HLA-matched tumor …

Discordant Molecular Biomarkers In Unfavorable Intermediate-Risk Localized Prostate Cancer, Michael Rooney, Krishnan R Patel, Shalin Shah, Justin R Gregg, Steven Jay Frank, Karen Hoffman, Ryan Park, Comron J Hassanzadeh, Seungtaek Choi, Sean Mcguire, Quynh-Nhu Nguyen, Daniel N Costa, Patricia Troncoso, Sumit K Subudhi, Shuang George Zhao, Curtis A Pettaway, Paul Corn, Chad Tang, Phuoc T Tran

Faculty, Staff and Students Publications

No abstract provided.

Risk Stratification As A Guide To Goal-Oriented Management Of Patients With Fibrotic Interstitial Lung Disease: A Registry-Based Analysis, Jürgen Behr, Antje Prasse, Hubert Wirtz, Dirk Koschel, David Pittrow, Matthias Held, Jens Klotsche, Stefan Andreas, Martin Claussen, Christian Grohé, Heinrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner, Sven Gläser, Claus Neurohr, Martin Schwaiblmair, Katharina Buschulte, Tobias Veit, Marion Frankenberger, Christopher J Ryerson, Kerri A Johannson, Veronica Marcoux, Jolene H Fisher, Deborah Assayag, Helene Manganas, Nasreen Khalil, Martin Kolb, Michael Kreuter

Faculty, Staff and Students Publications

Introduction: Idiopathic pulmonary fibrosis (IPF) has high morbidity and mortality with limited treatment options. Goal-oriented management approaches, such as the "treatable traits" concept, have yet to be implemented in IPF. This study aims to identify specific treatment goals in IPF for potential interventions by analysing outcomes from two national registries.

Methods: We used data from the INSIGHTS-IPF registry, comprising 1232 IPF patients, enrolled from 2014 to 2020 as derivation cohort. Baseline and 6-month follow-up data were examined to assess clinical progression and predict 1-year mortality. Variables included forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide ( …

Dual Targeting Of Amrc12 And Malassezia Globosa Disrupts Myc Liquid Condensates-Driven Nuclear Pore Complex Biogenesis In Neuroblastoma, Anpei Hu, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Jiaying Qu, Xiaojing Wang, Liduan Zheng, Qiangsong Tong

Faculty, Staff and Students Publications

Rationale: Neuroblastoma (NB) is a predominant extra-cranial malignancy in childhood, while molecular drivers of its progression and effective treatment strategies have yet to be clarified.

Methods: RNA sequencing was performed to identify transcriptional regulators and corresponding target genes. To explore the biological effects and underlying mechanisms of these regulators, a comprehensive methodology was utilized, encompassing chromatin immunoprecipitation, dual-luciferase reporter assay, qRT-PCR, western blot, alongside gene over-expression and silencing techniques, co-immunoprecipitation, and mass spectrometry. The MTT assay, soft agar colony formation, Matrigel invasion, and nude mouse xenograft models were applied to assess oncogenic properties. Patient survival was analyzed using the log-rank …

A Rare Case Of Eosinophilic Granulomatosis With Polyangiitis Following Development Of Central Diabetes Insipidus: A Case Report And Literature Review, Tatsuaki Kosaka, Shinya Yamamoto, Naoko Yasugi, Sayaka Sugioka, Takuro Hakata, Rintaro Saito, Ryosuke Hiwa, Sho Koyasu, Yuki Teramoto, Motoko Yanagita

Faculty, Staff and Students Publications

Central diabetes insipidus (CDI) can develop as an acquired systemic disease. However, cases of eosinophilic granulomatosis with polyangiitis (EGPA) with concurrent CDI are rare. We herein report a case of EGPA following CDI. A 68-year-old woman with a 30-year history of sinusitis and asthma developed CDI, followed by severe renal dysfunction with eosinophilia and elevated myeloperoxidase-antineutrophil cytoplasmic antibody levels. A renal biopsy confirmed EGPA. Intensive treatment resulted in dialysis discontinuation, while partial improvement in arginine vasopressin secretion suggested a potential link between EGPA and CDI. We also conducted a literature review on concurrent EGPA and CDI. Clinicians should be aware …

Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits With Severe Acute Kidney Injury Successfully Managed By Clone-Directed Therapy: A Case Report, Shohei Maekawa, Shinya Yamamoto, Tatsuaki Kosaka, Hisashi Kamido, Yasuyuki Arai, Yayoi Ogawa, Naoka Murakami, Yuki Teramoto, Motoko Yanagita

Faculty, Staff and Students Publications

Introduction

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a form of monoclonal gammopathy of renal significance, characterized by kidney injury caused by monoclonal immunoglobulin deposition in the glomeruli. While detectable clones are only found in 20–30% of PGNMID, plasma cell- or B-cell-targeting therapies are suggested to be effective. Recent case reports suggested immune dysregulation, such as viral infections or vaccinations, could potentially trigger the onset or relapse of PGNMID. Here, we report a case of PGNMID without detectable clones, which relapsed after viral enteritis, presenting with severe acute kidney injury (AKI) and nephrotic syndrome.

Case Presentation

A 60-year-old man, …

Bile Acid Profiles Define Disease-Specific Cholestatic States In Primary Sclerosing And Primary Biliary Cholangitis, Brian D Juran, Bryan M Mccauley, Chang Hu, Ahmad H Ali, Erik M Schlicht, Jackie K Bianchi, Marjana J Schell, Elizabeth J Atkinson, Johannes R Hov, Mette Vesterhus, William Rosenberg, Nicholas F Larusso, Gregory J Gores, Tom H Karlsen, Konstantinos N Lazaridis

Faculty, Staff and Students Publications

Background and aims: Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic cholestatic liver diseases with overlapping features but distinct biology. While bile acids (BAs) are central to cholestatic pathophysiology, the extent to which circulating BAs define disease-specific states remains unclear.

Methods: Plasma BA profiling and clinical laboratory tests were performed in patients with PSC (n = 269), PBC (n = 262), and matched controls (n = 269/262), respectively. BA composition, conjugation patterns, and pool characteristics were compared within and across diseases. Associations with hepatic decompensation were evaluated using univariable and exploratory multivariable analyses, including comparison with established …

Layers To Leaves: A Suite Of Modular 3d Printed Hydroponics Components For Research And Education, Ethan A Shaw, Suraj K Chandramouli, Michael P Dzakovich

Faculty, Staff and Students Publications

Hydroponics is a widely utilized technique to precisely control the plant growing environment and maximize productivity. In some cases, hydroponics systems can be expensive and require specialized expertise to build and maintain. Here, we present a suite of 3D-printed devices that can be constructed into a single or double tower hydroponics system of variable height and composition. This system is easily scalable to fit the needs of a user and can be implemented in a variety of research and educational contexts. Components in this suite can be made from inexpensive plastic filament using household-grade 3D printers. The vertical design of …

Researching A New Religious Phenomenon Of The Central Asia: Digital Sufism, Bekzhan A. Azhimov, Nurlan Kairbekov, Jolaman Bulan, Tussipkhan Imammadi

Occasional Papers on Religion in Eastern Europe

This study examines the emergence of digital Sufism as a modern spiritual phenomenon. It investigates the participation of Sufi groups on social media, the themes conveyed in their online sermons, and the ways their digital strategies compare with other Islamic organizations. The article further explores how Sufi orders navigate virtual environments, questioning whether they reveal elements of esoteric knowledge in these spaces. The notion of digital Sufism is presented as a lens for understanding how Sufi traditions integrate modern technology to widen the influence and relevance of their teachings. The research highlights how Sufism has adjusted to the challenges of …

Legislative Support Of Religious Policy In Ukraine Under Martial Law, Volodymyr Karpunets, Andrii Shevchuk, Oleksandr Bilchuk

Occasional Papers on Religion in Eastern Europe

The article examines the legislative framework of Ukraine's religious policy under the conditions of martial law caused by the full-scale armed aggression of the Russian Federation. The constitutional foundations of state-confessional relations are analyzed, particularly the provisions of Article 35 of the Constitution of Ukraine on freedom of conscience and religion, as well as Article 64, which provides for the possibility of temporary restrictions on religious rights under martial law. Key legislative acts are reviewed: the Laws of Ukraine "On Freedom of Conscience and Religious Organizations" (1991, with amendments in 2018 and 2019), "On the Legal Regime of Martial Law" …

From The History Of The Arrival Of The True Cross In Georgia, Giorgi Sosiashvili, Aleksandre Mgebrishvili Prof. Dr.

Occasional Papers on Religion in Eastern Europe

This article explores the complex historical and theological narratives surrounding the arrival of the True Cross—the Life-Giving Wood—in Georgia, as preserved in medieval Georgian chronicles and ecclesiastical writings. Drawing upon primary sources such as the Conversion of Kartli, the chronicles of Leonti Mroveli, Nikoloz Gulaberidze, and Arsen Ikaltoeli, as well as later accounts by Prince Teimuraz, Niko Dadiani, and Platon Ioseliani, the study reconstructs the multi-layered tradition of how fragments of the Holy Cross were brought from Byzantium to Kartli during the reign of King Mirian. According to these sources, Emperor Constantine the Great and Queen Helena dispatched to Georgia …

Preservation Of Architectural-Religious Heritage In Modern Ukraine, Olga Gold, Maksym Vasalatiy, Olga Dobrodum

Occasional Papers on Religion in Eastern Europe

This article examines answers to a number of pressing questions regarding the preservation of architectural heritage in the modern world: what philosophical views underlie the preservation of world heritage; and what is unique about the protection of religious architectural heritage. The architectural philosophy of religious buildings represents a complex of original concepts, both material and spiritual. The hypothesis consists of constructing an algorithm and mechanism for protecting cultural heritage from the perspective of the philosophy of architecture in post-war Ukraine. The preservation of historical and cultural heritage sites is one of the most complex areas of activity in the fields …

Moral Quandaries In Extremis: The Last Thing By Leopold Lahola, Madeline Vadkerty

Occasional Papers on Religion in Eastern Europe

A review of Leopold Lahola, The Last Thing. Translated by Julia and Peter Sherwood. Prague, Karolinum Press, 2025. 217 pages, paperback, ISBN 978-80-246-6041.7

Injuries In Children Undergoing Subspecialty Abuse Evaluations Because Of Intimate Partner Violence, M Katherine Henry, Gunjan Tiyyagura, Joanne N Wood, Jan Leonard, Kristine A Campbell, Daniel M Lindberg, Angela N Bachim, Farah W Brink, Lori D Frasier, Nancy S Harper, Claire Hickey, Natalie Laub, John D Melville, Hannah Sahud, Philip V Scribano

Faculty, Staff and Students Publications

Background and objectives: Intimate partner violence (IPV) and child physical abuse often co-occur, but the frequency and risk factors for abusive injuries in IPV-exposed children remain unknown. Our objectives were to (1) determine frequency of skeletal surveys (SSs) and neuroimaging use because of IPV and their diagnostic value in children aged less than 24 months evaluated by a child abuse pediatrics specialist (CAP) and (2) identify factors associated with performance of and findings on SS and neuroimaging.

Methods: We conducted a retrospective study of children aged less than 24 months undergoing CAP consultations because of IPV exposure from February 2021 …

Tracheobronchial Mucoepidermoid Carcinoma In Four Pediatric Patients, Kalen Hendra, Muhammad Ijlal Khan, Mitali Thanawala, Manuel Silva-Carmona, Eric D Zee

Faculty, Staff and Students Publications

Pediatric tracheobronchial mucoepidermoid carcinoma (MEC), also called pulmonary MEC, is a rare malignant primary lung neoplasm that is typically found in the large airways. Patients may present with symptoms such as cough, pneumonia, fever, hemoptysis, dyspnea, wheezing, chest pain, weight loss, and fatigue. These nonspecific symptoms (or lack of symptoms in some cases) often result in a delayed diagnosis. Chest CT typically demonstrates findings consistent with bronchial obstruction and diagnosis is made via histopathology. Surgical resection is the mainstay of treatment and children often have favorable outcomes. Here we present four cases of tracheobronchial MEC in children treated at three …

Use Of New Tobacco And Nicotine Products As A Harm Reduction Strategy: A Critical Review Of The Evidence, Carlos Andrés Jimenez-Ruiz, José Ignacio De Granda-Orive, Carlos Rábade Castedo, Harold J Farber, Angélica Ocampo, Susana Luhning, Beatriz Raboso-Moreno, Lola Del Puerto-Garcia, Daniel Buljubasich, Manuel Conrado Pacheco-Gallego, José Antonio Castillo-Vizueta, Rosa Mirambeaux-Villalona, Marcos García-Rueda, Juan Antonio Riesco-Miranda, Ángela Ramos-Pinedo, Jaime Signes-Costa, Ledys Blanquicett-Barrios, Eva De Higes-Martinez, Catalina Casillas-Suarez, Concepción Rodríguez-García, Cristina Villar-Laguna, Gloria Francisco-Corral, Esther Pastor-Esplá, Paz Vaquero-Lozano, Francisco Carrion-Valero, Lourdes Cañón-Barroso, Raúl Sandoval-Contreras, Inmaculada Gorordo-Unzueta, Ruth Pitti-Pérez, María Ángeles Muñoz-Vidal, Susana Calvo-Pascual, Eva Cabrera-Cesar, Germán Díaz-Santos, Maribel Cristóbal-Fernández

Faculty, Staff and Students Publications

The sale, distribution, and indiscriminate use of new tobacco and nicotine products have multiplied. The most relevant products are: electronic cigarettes (ECs), heated tobacco (HT), and nicotine pouches (NPs). From the tobacco industry and its related health sectors, and even from some health institutions with no clear influence from this industry, the use of all these devices is being promoted as an excellent harm reduction strategy for those conventional tobacco smokers who do not want to or cannot quit smoking. This paper reviewed the lack of scientific evidence of this strategy.

Association Of Alcohol Use With Helmet Use In Cyclists: Analysis Of The National Trauma Data Bank, Daniel C Brock, Gaibo Yan, Chad T Wilson, Emanuel Narcis Husu

Faculty, Staff and Students Publications

Background: Helmet use significantly reduces the risk of traumatic brain injury among cyclists; however, the influence of alcohol use on helmet-wearing adherence remains understudied in large national data sets. The goal of this study was to investigate the relationship between alcohol use and helmet use in injured cyclists.

Methods: This study is a retrospective cross-sectional analysis of 155 766 cyclists with traumatic injuries from the National Trauma Data Bank spanning 8 years (2017-2023). Cyclists were categorized by blood alcohol concentration (BAC) as follows: not screened, sober (BAC < 0.02), impaired (BAC 0.02-0.08), intoxicated (BAC ≥0.08), and multidrug intoxicated (BAC ≥0.08 plus ≥1 positive drug screen). The primary outcome was helmet usage. Secondary outcomes included mortality, hospital and intensive care unit length of stay, Injury Severity Score, and adverse events. Comorbid substance use disorders were considered as covariates.

Results: Alcohol use was associated with a dose-response decrease in helmet use. Helmet …