Digital Commons Network^™

Risk Stratification As A Guide To Goal-Oriented Management Of Patients With Fibrotic Interstitial Lung Disease: A Registry-Based Analysis, Jürgen Behr, Antje Prasse, Hubert Wirtz, Dirk Koschel, David Pittrow, Matthias Held, Jens Klotsche, Stefan Andreas, Martin Claussen, Christian Grohé, Heinrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F Meyer, Joachim Kirschner, Sven Gläser, Claus Neurohr, Martin Schwaiblmair, Katharina Buschulte, Tobias Veit, Marion Frankenberger, Christopher J Ryerson, Kerri A Johannson, Veronica Marcoux, Jolene H Fisher, Deborah Assayag, Helene Manganas, Nasreen Khalil, Martin Kolb, Michael Kreuter

Faculty, Staff and Students Publications

Introduction: Idiopathic pulmonary fibrosis (IPF) has high morbidity and mortality with limited treatment options. Goal-oriented management approaches, such as the "treatable traits" concept, have yet to be implemented in IPF. This study aims to identify specific treatment goals in IPF for potential interventions by analysing outcomes from two national registries.

Methods: We used data from the INSIGHTS-IPF registry, comprising 1232 IPF patients, enrolled from 2014 to 2020 as derivation cohort. Baseline and 6-month follow-up data were examined to assess clinical progression and predict 1-year mortality. Variables included forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide ( …

Perceived Barriers And Recommendations To Improve Well-Child Visits Among Medicaid Enrollees: An Explanatory Sequential, Mixed-Methods Study, Shawnda Schroeder, Keona Manuelito

Indigenous Health Faculty Publications

Despite the critical role of well-child visits (WCVs) in preventive care, many Medicaid-enrolled children miss these appointments, leading to gaps in early intervention and immunization. Existing research has largely focused on either quantitative analyses of visit rates and predictors or qualitative insights into patient and provider experiences. This study employs a mixed-methods, community-based approach to examine barriers to WCV attendance among Medicaid-enrolled families in North Dakota who missed all WCVs in 2021. Through administrative data analysis (n=64,364), surveys (n=1,294), and focus groups (n=40), findings reveal structural, economic, and cultural obstacles, including cost concerns, lack of Medicaid transparency, and logistical challenges. …

Brewed Differently: Comparing Subheading Use In Embase And Medline, Cynthia M. Schmidt, Danielle Westmark

Posters and Presentations: Leon S. McGoogan Health Sciences Library

This project compared MEDLINE and Embase indexers' use of therapy subheadings and discusses the implications for literature searching. Objectives Our long experience with MEDLINE searching and attendance at NNLM-sponsored PubMed training sessions taught us to depend on specific patterns of subheading use by MEDLINE’s indexers. For instance, we learned to expect that drug trials would be indexed with a drug heading combined with a therapeutic use subheading. Our library licensed EMBASE in 2012. We soon began to suspect that subheading application was not as predictable in EMBASE as it was in MEDLINE. We wanted the recommendations we provide novice EMBASE …

Longnose Dace: Place-Based Learning Plan For The Msum Regional Science Center, Madison Tillman

OER Materials

This lesson will be used to help students create connections with specific traits of the Longnose dace and why the traits are beneficial for their environment. This lesson uses the 5E model and should be used at the MSUM Regional Science Center to help provide real-life examples and encourage inquiry.

Silver Leaves On The Prairie: Investigating What Prairie Sage Needs, Taylor Lau

OER Materials

In this place-based lesson, fifth-grade students investigate a living prairie sage (Artemisia ludoviciana) plant, native to the Moorhead, Minnesota area, during a curiosity walk at the MSUM Regional Science Center. Aligned to Minnesota benchmark 5L.1.2.1.3, students collect at least three pieces of evidence, including measurements and observations of sunlight and soil, to show that plants get the materials they need for growth chiefly from air and water. Using the 5E model, students connect their findings to photosynthesis and Van Helmont’s willow experiment, then write a claim, evidence, and reasoning response about the conditions prairie sage needs to grow …

Using A Multimedia Icu Diary To Support Patient Recovery And Enhance Family Engagement In The Medical Intensive Care Unit Primary, Eliza Palow

MaineHealth Maine Medical Center

The purpose of this project was to design and implement a multimedia ICU diary incorporating QR-coded educational tools to support patient and family engagement, improve understanding of the ICU environment, and enhance emotional orientation and recovery during and after hospitalization.

The Fundamentals Of Care (Foc) Experience: Educators Introducing Clinical Staff To The Fundamentals Of Care Through Technology., Ashley E. Cunningham, Sophia Ouellette

MaineHealth Maine Medical Center

The aim of this project was to examine how watching a video explanation of the Fundamentals of Care Framework would influence clinical staffs’ reflections on their implementation of fundamental care.

A Retrospective Study Of Dietitian Assessment On 30-Day Readmission In Hospitalized Adults With Malnutrition, Paul Blakeslee, Kristiina Hyrkas, Wendy Craig, Rachel Haskell

MaineHealth Maine Medical Center

The aim of this study was to evaluate the impact of nutrition assessment on 30-day readmission of adults who were discharged with a diagnosis of malnutrition by conducting a secondary analysis.

Rethinking Orientation: Embedding The Fundamentals Of Care Framework In The Onboarding Of Newly Licensed Nurses, Angela Cyr

MaineHealth Maine Medical Center

The transition from education to NICU practice is a vulnerable and high‑stakes period for new nurses, requiring rapid clinical, emotional, and professional adaptation. Grounded in the Fundamentals of Care framework, this work reframes orientation as a person‑centered, relational process that supports readiness, well‑being, and sustainable practice.

Scalar Source Localization Using Multi-Sensor Domains Of Dependence In Turbulent Channel Fow, Zejian You, Xiaowei Zhu, Qi Wang

Mechanical and Materials Engineering Faculty Publications and Presentations

Tracking hazardous events such as wildfire smoke, coastal oil spills, or chemical releases in natural environments is complicated by turbulent dispersion and molecular diffusion. This study presents a method to localize pollutant sources rapidly and accurately using infinite time-averaged measurements from a multi-sensor network, leveraging the duality between mean forward and adjoint scalar fields. The forward-adjoint duality states that measurements at the sensor (forward feld) are equal to the adjoint field at the source, providing crucial spatial information about the source. Consequently, the adjoint scalar fields can be interpreted as the domain of dependence for the sensor observations [1, 2]. …

Supporting Clinical Readiness And Well-Being In New Graduate Nurses: A Scoping Review, Angela Cyr Msn, Rn, Rnc-Nic, Npd, Bc

MaineHealth Maine Medical Center

Objectives: To map and synthesize current evidence on orientation strategies that integrate clinical and psychosocial support for newly licensed nurses, with a focus on first-year retention outcomes.

Competency Campfire Stories: S'Mores & Skills, Competency & Curriculum, Sparks & Social Media, Emily Bovino Msn, Rn, Cnl, Ccrn, Michael Defrancisco Msn, Rn, Britney Meunier Msn, Rn, Ccrn, Amy Stafford Dnp, Aprn, Ccns, Kristen Stogsdill Bsn, Rn, Ccrn

MaineHealth Maine Medical Center

Learning Objectives

• Identify strategies to foster connections and build confidence among new nurses by creating a supportive, interactive learning environment.

• Describe how to design and facilitate the Camp Competency onboarding experience to engage new nurses through interactive learning.

• Incorporate social media tools to enhance learner interaction and community-building.

Evolving Practices From Fasting To Non-Fasting Before Cardiac Catheterization: A Scoping Review, Sungjun Park Bsn, Cvbc, Cmsrn, Rn, Kristiina Hyrkas Phd, Licnsc, Mnsc, Rn

MaineHealth Maine Medical Center

NPO before cardiac catheterization may overstate aspiration risk: evidence supports allowing clear liquids before catheterization.

From Evidence To Action: Optimizing Ards Care In The Icu, Amy Stafford Dnp, Aprn, Ccns

MaineHealth Maine Medical Center

Objectives

• Define ARDS using historical and current diagnostic criteria

• Explain the pathophysiology of ARDS and its impact on lung mechanics, including compliance, driving pressure, and recruitable lung

• Recognize limitations of common monitoring tools, including pulse oximetry, and incorporate this into clinical decision-making

• Apply evidence-based management strategies for ARDS, including lung protective ventilation, PEEP optimization, proning, and adjunctive therapies

• Analyze clinical case scenarios to make decisions related to ventilator management, oxygenation strategies, and escalation of care

Changing Culture Through Shared Passion: How We Found Our Identity In The Medical Icu, Lorrie Sluti Bsn, Rn, Ccrn, Alison Griffin Bsn, Rn, Ccrn, Megan Massey Bsn, Rn

MaineHealth Maine Medical Center

The purpose is to examine the cultural transformation of a Medical Intensive Care Unit after the COVID-19 pandemic; highlighting how the development of a Unit-Based Practice Council restored unit identity, nursing job satisfaction, and improved patient outcomes.

Aerocom: Winter 2026, John D. Odegard School Of Aerospace Sciences

Aerocom: John D. Odegard School of Aerospace Sciences Alumni Magazine

No abstract provided.

Demographic Response Of Rana Uenoi To Land Use Near Breeding Sites: A Case Study From The Gayasan Region, South Korea, Hyun Kim, Hyun Tae Kim, Na Yeong Kim, Soo Dong Lee, Jared Wolfe

Michigan Tech Publications

Amphibians are highly sensitive to habitat disturbance because of their permeable skin and reliance on both aquatic and terrestrial environments. To evaluate how human-driven land-use change affects a forest-stream amphibian, we analysed long-term population dynamics of Rana uenoi in the Gayasan region of South Korea, with a focus on breeding habitats. Between 2007 and 2023, annual egg-mass surveys were conducted at 14 breeding sites, and land-use composition was extracted each year within a 500 m buffer from national geospatial databases. Land-use categories were reclassified into ecologically relevant groups (breeding, high-quality, low-quality and non-living/high-mortality habitats) and their areas were quantified for …

Examining Team Leader Visual Dynamics And Team Performance In Pediatric Emergency Simulations, Annamarie Brosnihan

Graduate Studies Theses and Dissertations 2026

Pediatric medical emergencies are dynamic, high-intensity clinical situations that demand coordinated interdisciplinary actions for optimal patient outcomes. Effective teamwork and leadership are critical, especially during the preparatory phase. Here, team leaders define task goals, assign individual roles, and maintain situational awareness. This phase directs attention, organizes team dynamics, and ensures medical interventions are deployed properly. Medical simulations provide a unique opportunity to capture dynamic leadership behaviors in a controlled low-stakes environment using multimodal data, such as eye tracking, to gain insight into team leader cognitive processes (i.e., attention allocation and information processing). Prior research suggests that leaders who visually attend …

Restoring The Wild East: Predicting Public Support For Cougar And Red Wolf Reintroduction In The Eastern United States, Benjamin Ghasemi, Jeremy T. Bruskotter, John A. Vucetich, L. Mark Elbroch, Robyn S. Wilson, Neil H. Carter, Axel Moehrenschlager, Shelby Perry, Joseph W. Hinton

Michigan Tech Publications

Restoring large carnivores to human-dominated landscapes remains ecologically and socially contentious, though reintroduction may offer important benefits where coexistence is possible. Yet, efforts to reintroduce cougars (Puma concolor) and red wolves (Canis rufus) in the Eastern U.S. face major challenges, largely due to human-caused mortality and opposition. We employed the hazard acceptance model and structural equation modeling to investigate the socio-psychological drivers of public support for reintroduction. Survey data were collected from residents of the Eastern U.S. for cougars (n = 2665) and red wolves (n = 3825). For both species, support was positively associated with perceived personal and societal …

Developing The Whole Child: A Retrospective Ethnographic Case Study Of Prosocial Learning Efforts At One Elementary School, Bevan Brown

Graduate Studies Theses and Dissertations 2026

An alarming trend among elementary-aged students in the United States exhibiting significant deficits in social-emotional competency development has intensified since the Covid-19 pandemic. Challenges in developing competent prosocial skills in the elementary-aged years have been associated with difficulties in emotional regulation and social interactions, which can result in compromising school readiness and long-term academic success. Existing school infrastructure provides a vehicle for early intervention, specifically in supporting students with poor social and emotional wellbeing. Thus, the need for innovative pedagogical and instructional approaches that address the complex challenges of the 21st century has become increasingly essential. Coordinated approaches to prosocial …

Detonability Limits Of Liquid Fuel Cloud, Khaoula Chougag

Graduate Studies Theses and Dissertations 2026

Detonation-based propulsion systems are of significant interest owing to their high thermodynamic efficiency, rapid energy release, and favorable entropy production relative to deflagration-based systems. Liquid fuels offer practical advantages in storage and volumetric energy density, making them attractive candidates for next-generation detonation engines. This dissertation investigates the detonability characteristics of liquid hydrocarbon fuel clouds through three interconnected studies conducted in a turbulent shock-tube environment using high-speed imaging and pressure diagnostics. The first study maps the detonability limits of monodisperse n-dodecane clouds by systematically varying droplet diameter (5-50 μm) and O₂/N₂ oxidizer composition at equivalence ratios spanning ϕ = 0.8-2.0. Results …

Yspiwrites Anthology: Selected Fiction, Art, And Poetry, Angelica Esquivel, Ypsiwrites

YpsiWrites Featured Writing

No abstract provided.

Do Fair Schedules Matter? Work-Home Conflict And Justice In Emergency Medicine, Maresca J. Brand

Graduate Studies Theses and Dissertations 2026

Emergency physicians work in a high-demand environment requiring irregular, around-the-clock schedules, which can contribute to elevated work-home conflict and burnout. While previous research has focused on objective schedule characteristics such as length of shift or time of day worked, less attention has been given to how emergency physicians perceive the fairness of the scheduling process itself. Drawing on Work-Home Resources Theory and Personal Resource Allocation Theory, this study examines whether perceptions of schedule justice influence work-home conflict via schedule satisfaction. I propose that perceived fairness in schedule creation functions as a contextual resource that shapes whether a schedule is experienced …

Case Report: Primed Dendritic Cell Immunotherapy For Multiple Solid Tumors, Jeffrey Jones, Aly Alrabaa, William Decker, Luis Ferbeyre, Gregorio Viramontes, Rafael Gonzalez, Elideth Angulo, Antonio Zamudio, Raul Hernandez, Stephen Noga, Susana Hernandez-Reyes, Paul Zhang, Darryl Smith, Ara Karamanian, Luis Tamara, Dalton Greenwood, Matthew Halpert

Faculty, Staff and Students Publications

Many patients with advanced solid tumors ultimately develop resistance to conventional therapies, with especially limited options for those experiencing rapid progression or poor performance status, highlighting the need for personalized immunotherapies capable of inducing durable responses. In this retrospective case series, we describe the clinical course and outcomes of five adults (4 male, 1 female; median age 51 years [range, 39-62]) with metastatic solid tumors who achieved complete and durable remission following doubly loaded autologous dendritic cell therapy after failure of standard treatments, such as immune checkpoint inhibition, radiation, surgery, or endocrine therapy. Five patients, including prostate adenocarcinoma (n=1), malignant …

Metabolites Produced By Agat+ Cells Support Regeneration In The Planarian Schmidtea Mediterranea, Aubrey M Kent, Carlos Guerrero-Hernández, Carolyn Brewster, Sean Mckinney, Jason A Morrison, Mary C Mckinney, Eric J Ross, Frederick G Mann, Blair W Benham-Pyle, Alejandro Sánchez Alvarado

Faculty, Staff and Students Publications

Planarians exhibit extraordinary regenerative abilities driven by pluripotent neoblasts, yet the roles of post-mitotic progenitor and differentiated cells in this process remain incompletely understood. Here, we investigate the function of agat+ cells, epidermal progenitors expressing members of the arginine:glycine amidinotransferase (agat) gene family, in the regeneration of Schmidtea mediterranea. Comprehensive analysis of all five planarian agat paralogs revealed that agat-1, -2, -3, and -4 are co-expressed in subepidermal populations enriched at wound sites, while agat-5 is minimally expressed. RNAi-mediated knockdown of agat-1 and agat-2 resulted in severe defects: agat-1 primarily disrupted tissue homeostasis, …

Inheriting Chromosome Conformation, Kyle P Eagen

Faculty, Staff and Students Publications

No abstract provided.

Personalizing Therapies Over The Course Of Hormone Receptor-Positive/Her2-Negative Metastatic Breast Cancer, Akshara Singareeka Raghavendra, Senthil Damodaran, Carlos H Barcenas, Suzanne A Fuqua, Rachel M Layman, Debu Tripathy

Faculty, Staff and Students Publications

The hormone receptor (HR)‐positive/human epidermal growth factor receptor 2 (HER2)‐negative breast cancer subtype accounts for most early and metastatic breast cancer (MBC) cases. HR‐positive/HER2‐negative MBC is characterized by a relatively prolonged, although variable, disease course and substantial intertumoral and intratumoral heterogeneity. Although endocrine‐based therapies remain the cornerstone of treatment, nearly all patients eventually develop resistance, which is increasingly addressed with biologically targeted agents and newer‐generation cytotoxic drugs. This review summarizes the current understanding of HR‐positive/HER2‐negative MBC biology, highlighting mechanisms of intrinsic and acquired resistance, including driver genomic alterations that, along with clinical factors, help guide therapeutic choices and sequencing. The …

Esr1 Fusions In Breast Cancer: Functions, Mechanisms And Therapeutic Opportunities, Xuxu Gou, Zoya Farooqui, Charles E Foulds

Faculty, Staff and Students Publications

Approximately 70% of all breast cancers are driven by estrogen receptor-alpha (ERα) that binds the predominant circulating female estrogen, 17ꞵ-estradiol (E2). Because of this, drugs collectively termed “endocrine therapy (ET)” that either suppress E2 level or inhibit the activity of ERα have been used as first-line therapy. While initially effective, resistance to ET drugs occurs with subsequent lethal metastasis. The most common genetic alterations are point mutations in the ESR1 gene within the last exon encoding the ligand-binding domain (LBD), resulting in constitutively active ERα proteins. Recently, new oral selective estrogen receptor degraders (SERDs) that effectively target these point mutants …

Surface Marker Identification To Capture Live Circulating Tumor Cells In Metastatic Triple-Negative Breast Cancer, Bree M Lege, Khushali J Patel, Brendan Panici, Ping Gong, Michael T Lewis, Matthew J Ellis, Chonghui Cheng

Faculty, Staff and Students Publications

Metastatic triple-negative breast cancer (TNBC) is highly aggressive and lacks targeted therapies. Circulating tumor cells (CTC) are invaluable for monitoring metastatic tumor progression and treatment response but are difficult to capture because of their rarity and heterogeneity. Surface-based staining for live CTCs is essential to preserve RNA quality in single cells, but current markers tend to perform poorly on more mesenchymal tumor cells such as TNBCs. To enhance live TNBC CTC detection, we developed a workflow for live CTC capture and single-cell RNA sequencing (scRNA-seq). Using a mouse model of metastatic TNBC, we identified four new CTC surface markers, AHNAK2, …

Lysine Demethylase 4a Is A Centrosome-Associated Protein Required For Centrosome Integrity And Genomic Stability, Pratim Chowdhury, Xiaoli Wang, Richard I Han, Manga Motrapu, Ashley G Boice, Yuya Nakatani, Sofia Vargas-Hernandez, Julia F Love, Claude Chew, Sandra L Grimm, Dereck Mezquita, Frank M Mason, Elisabeth D Martinez, Cristian Coarfa, Cheryl L Walker, Anna-Karin Gustavsson, Ruhee Dere

Faculty, Staff and Students Publications

Centrosomes play a fundamental role in nucleating and organizing microtubules in the cell and are vital for faithful chromosome segregation and maintenance of genomic stability. Loss of structural or functional integrity of centrosomes causes genomic instability and is a driver of oncogenesis. Here we identify lysine demethylase 4A (KDM4A), an epigenetic 'eraser' of chromatin methyl marks, as a centrosome-localized protein, visualized at the nanometer-scale resolution. We additionally uncovered that KDM4A demethylase enzymatic activity is required to maintain centrosome homeostasis and integrity; a previously unknown functionality unlinked to altered expression of genes regulating centrosome number. We find that KDM4A interacts with …