Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2026

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 113791 - 113820 of 114555

Full-Text Articles in Entire DC Network

Winner, Best Appellate Brief In The 2025 Native American Law Student Association Moot Court Competition, Baylee Ogle, Madison Bailey Jan 2026

Winner, Best Appellate Brief In The 2025 Native American Law Student Association Moot Court Competition, Baylee Ogle, Madison Bailey

American Indian Law Review

No abstract provided.


Front Pages Jan 2026

Front Pages

American Indian Law Review

No abstract provided.


When Tribal Sovereign Immunity And The Americans With Disabilities Act Collide, Who Wins?, Baylee M. Ogle Jan 2026

When Tribal Sovereign Immunity And The Americans With Disabilities Act Collide, Who Wins?, Baylee M. Ogle

American Indian Law Review

No abstract provided.


Native Gifts In An Electric Universe: Exploring Tribal Sovereignty Through Digital Data, Spectrum, And Technological Imaginings, Michael Johnson Jan 2026

Native Gifts In An Electric Universe: Exploring Tribal Sovereignty Through Digital Data, Spectrum, And Technological Imaginings, Michael Johnson

American Indian Law Review

No abstract provided.


In Pursuit Of Federal Recognition: A Legal And Historical Analysis Of The Duwamish Tribe’S Fight For Federal Tribal Recognition, Gabrielle Gollihar Jan 2026

In Pursuit Of Federal Recognition: A Legal And Historical Analysis Of The Duwamish Tribe’S Fight For Federal Tribal Recognition, Gabrielle Gollihar

American Indian Law Review

No abstract provided.


Becerra V. San Carlos Apache Tribe And The Indian Self Determination & Education Assistance Act: Keeping Indian Health Services Responsible In The Wake Of Forced Sterilizations, Alexis K. O’Brien Jan 2026

Becerra V. San Carlos Apache Tribe And The Indian Self Determination & Education Assistance Act: Keeping Indian Health Services Responsible In The Wake Of Forced Sterilizations, Alexis K. O’Brien

American Indian Law Review

No abstract provided.


Tribal Civil Jurisdiction: Lexington V. Smith And The Evolution Of The Montana Framework, Will Speed Jan 2026

Tribal Civil Jurisdiction: Lexington V. Smith And The Evolution Of The Montana Framework, Will Speed

American Indian Law Review

No abstract provided.


Runt-Related Transcription Factor 2 Transcriptionally Represses Sirtuin 1 To Regulate Osteoclastogenesis And Tooth Eruption, Jie Li, Changqing Yan, Xinyi Sun, Chenying Zhang, Xiaozhe Wang, Yang Liu, Shuguo Zheng Jan 2026

Runt-Related Transcription Factor 2 Transcriptionally Represses Sirtuin 1 To Regulate Osteoclastogenesis And Tooth Eruption, Jie Li, Changqing Yan, Xinyi Sun, Chenying Zhang, Xiaozhe Wang, Yang Liu, Shuguo Zheng

Journal of Dental Sciences

Background/purpose: Cleidocranial dysplasia (CCD), caused by Runt-related transcription factor 2 (RUNX2) haploinsufficiency, features delayed tooth eruption. Although impaired osteoclastogenesis contributes to eruption failure, the direct molecular mechanisms linking RUNX2 deficiency to osteoclast dysfunction remain elusive. Sirtuin 1 (SIRT1) is a critical regulator of osteoclastogenesis; however, whether it serves as a downstream effector of RUNX2 remains unexplored. This study aimed to elucidate the mechanistic link between RUNX2 and SIRT1 in regulating osteoclast differentiation and tooth eruption.

Materials and methods: Tooth eruption and osteoclast differentiation were assessed by micro-computed tomography and histological analysis in Runx2+/- mice. Chromatin immunoprecipitation quantitative polymerase chain …


Ansys Discovery And Fluent Files For Modeling A Hydrocyclone With Scco2 And Coal Fly Ash, Isaiah Morones, Catherine Brewer Jan 2026

Ansys Discovery And Fluent Files For Modeling A Hydrocyclone With Scco2 And Coal Fly Ash, Isaiah Morones, Catherine Brewer

Chemical & Materials Engineering: Datasets

No abstract provided.


Variable Temperature And Moisture Requirements For Germination Within Populations Of Kochia (Bassia Scoparia) In Field Margins, Brian Schutte, Rebecca Creamer Jan 2026

Variable Temperature And Moisture Requirements For Germination Within Populations Of Kochia (Bassia Scoparia) In Field Margins, Brian Schutte, Rebecca Creamer

Entomology, Plant Pathology, & Weed Science: Datasets

No abstract provided.


The Trademark Bargain: Registration As Disclosure, Dustin Marlan Jan 2026

The Trademark Bargain: Registration As Disclosure, Dustin Marlan

Faculty Publications

This Article highlights the central—and under-theorized—role that disclosure plays within trademark law. By loose analogy, the patent disclosure requirement is a cornerstone of patent law, embodying the “patent bargain” where an inventor must disclose their invention in exchange for a twenty-year monopoly. This quid pro quo is believed to stimulate the progress of science and technology, making patent disclosure the very pulse of the patent regime. However, the fundamental importance of disclosure in trademark law remains underexplored. Like patents, trademark law imposes a rigorous bargain—to obtain the enhanced rights granted by federal registration, trademark owners must first make significant disclosures …


A First Amendment Right To Know, David S. Ardia Jan 2026

A First Amendment Right To Know, David S. Ardia

Faculty Publications

This Article tackles an increasingly important question: Can police round up people on American streets and keep secret the names of those they detain without violating the First Amendment? Alarmingly, the government made this very argument in the summer of 2020 when it sought to break up Black Lives Matter protests occurring in cities across the country. Based in part on a Supreme Court decision from the 1970s involving access to prisons, the government argued that the First Amendment imposes no constraints on government secrecy. If it is true that the government can shield its exercise of police power from …


Tradition Without Text?, Daniel B. Rice Jan 2026

Tradition Without Text?, Daniel B. Rice

Faculty Publications

This Essay critiques the Supreme Court’s emerging “history and tradition” methodology, as articulated in Dobbs v. Jackson Women’s Health Organization, arguing that its reliance on affirmative textual recognition in historical positive law fundamentally misrepresents the nature of American liberty traditions. By insisting that unenumerated rights are constitutionally cognizable only when earlier legal sources explicitly identified them as rights, the Court adopts a truncated evidentiary framework that privileges written enactments while disregarding lived experience, social practice, and the normative assumptions that shaped earlier understandings of permissible state power. The result, the Essay contends, is a mechanized and impoverished account of …


Desperation Finance: Merchant Cash Advances In Bankruptcy And Beyond, Kara J. Bruce Jan 2026

Desperation Finance: Merchant Cash Advances In Bankruptcy And Beyond, Kara J. Bruce

Faculty Publications

Over the last several years, Merchant Cash Advances (“MCAs”) have risen in prominence as a form of short-term financing for distressed small businesses. MCA transactions are distinct from most small-business lending because they are not structured as loans at all. Rather, in exchange for a lump sum of cash, the merchant purports to sell to the funder an unidentified percentage of its future receipts or receivables. This structure allows funders to sidestep the application of lending regulations and usury protections, but it strains the foundations of commercial law and generates a host of interpretive challenges.

Bankruptcy, district, and circuit courts …


Limits On Damages For Breach Of A Forum Selection Clause, John F. Coyle, Tanya Monestier Jan 2026

Limits On Damages For Breach Of A Forum Selection Clause, John F. Coyle, Tanya Monestier

Faculty Publications

When a plaintiff sues in a court other than the one designated in a forum selection clause, the defendant’s remedial options are limited. It can ask the court to dismiss the case outright. Or it can ask the court to transfer the case to the designated forum. The defendant typically cannot, however, recover money damages—in the form of attorneys’ fees and related expenses—that it incurs in the course of persuading the court that transfer or dismissal is appropriate. This is because the conventional wisdom among judges has long been that damages are not available for breach of a forum selection …


Health Care Fraud And The End Of Chevron, Joan H. Krause Jan 2026

Health Care Fraud And The End Of Chevron, Joan H. Krause

Faculty Publications

What do the Environmental Protection Agency’s “plantwide” definition of a “stationary” pollution source,” a National Marine Fisheries Service determination of who pays for fishing boat observers, and a Department of Health and Human Services rule governing the marketing of prescription drugs have in common? In short, a government agency’s interpretation of a federal statute. All three cases go to the heart of the administrative state: the ability of an agency, staffed by experts in the field, to interpret static statutory language to offer practical guidance to an ever-evolving industry.

The same is true of health care fraud, although it is …


Choice Of Law In Terrorism Cases, John F. Coyle Jan 2026

Choice Of Law In Terrorism Cases, John F. Coyle

Faculty Publications

When an Iranian-backed terrorist group operating out of Lebanon detonates a bomb in Israel that kills a U.S. citizen domiciled in Texas, what law governs civil claims brought against Iran in the District of Columbia? Some version of this choice-of-law question has been presented to U.S. courts many times over the past two decades. Their answers have been frustratingly inconsistent. In some cases, courts have applied the law of the place of the attack. In others, they have applied the law of the plaintiff’s domicile. In still others, they have applied the law of the forum where the plaintiff brings …


Journal Of Dental Sciences Editorial Board Jan 2026

Journal Of Dental Sciences Editorial Board

Journal of Dental Sciences

No abstract provided.


Dental Treatment And Oral Care For Patients With Severe Mental Illness Receiving Psychiatric Home-Visit Care: A Narrative Review With An Illustrative Case, Takayuki Suga, Trang Thi Huyen Tu, Yuji Gamo, Takafumi Asakura, Shigeru Iida, Akira Toyofuku Jan 2026

Dental Treatment And Oral Care For Patients With Severe Mental Illness Receiving Psychiatric Home-Visit Care: A Narrative Review With An Illustrative Case, Takayuki Suga, Trang Thi Huyen Tu, Yuji Gamo, Takafumi Asakura, Shigeru Iida, Akira Toyofuku

Journal of Dental Sciences

Patients with severe mental illness (SMI) often have untreated caries, periodontal inflammation, tooth loss, xerostomia-related risk, dental anxiety, and delayed dental attendance. This narrative review aimed to synthesize evidence relevant to dental treatment planning for patients with SMI receiving psychiatric home-visit care and to clarify when domiciliary dental assessment and repeated professional oral care may be indicated. Targeted literature searches and citation tracking were used to identify reviews, epidemiological studies, intervention studies, qualitative syntheses, and special care dentistry guidance. The evidence indicates that oral disease in SMI reflects not only limited knowledge but also avolition, cognitive impairment, psychosis, sedation, medication-induced …


Higher Serum Gastric Parietal Cell Antibody Titers Are Associated With Increased Frequencies Of Macrocytosis, Vitamin B12 Deficiency, And Hyperhomocysteinemia In Patients With Oral Lichen Planus, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang Jan 2026

Higher Serum Gastric Parietal Cell Antibody Titers Are Associated With Increased Frequencies Of Macrocytosis, Vitamin B12 Deficiency, And Hyperhomocysteinemia In Patients With Oral Lichen Planus, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous study found 139 gastric parietal cell antibody (GPCA)-positive oral lichen planus (OLP) patients (GPCA+OLP patients) in a group of 588 OLP patients. This study evaluated whether higher-titer (serum GPCA titer ≥ 160) GPCA+OLP patients had greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and hyperhomocysteinemia than lower-titer (GPCA titer ≤ 80) GPCA+OLP patients or 588 healthy control subjects.

 

Materials and methods: Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 53 higher-titer GPCA+OLP patients, 86 lower-titer GPCA+OLP patients, and …


Evaluation Of Condylar Position Displacement Using Various Centric Relation Recording Techniques Based On Maximum Intercuspation Position: A Systematic Review And Meta-Analysis, Ling-Shiuan Huang, Yen-Chang Huang, I-Ting Wu, Shinn-Jyh Ding Jan 2026

Evaluation Of Condylar Position Displacement Using Various Centric Relation Recording Techniques Based On Maximum Intercuspation Position: A Systematic Review And Meta-Analysis, Ling-Shiuan Huang, Yen-Chang Huang, I-Ting Wu, Shinn-Jyh Ding

Journal of Dental Sciences

Background/ purpose: Restoring tooth defects is a key clinical task for dentists, aimed at either maintaining or reconstructing a functional occlusal dentition. This study conducted a systematic review and meta-analysis of clinical trials comparing centric relation (CR) and maximum intercuspal position (MIP) condylar positions obtained using various CR techniques, and to verify the reproducibility of these methods.

Materials and methods: The PubMed, Embase, Google Scholar, and Cochrane Library databases were searched for articles published before January 2026. The single-arm meta-analysis used a random-effects model to calculate the overall effect size.

Results: This study included 12 articles published …


Endothelin-1 Drives Cyclooxygenase-2 And Prostaglandin E2 Expression In Osteoblasts Through Mitogen-Activated Protein Kinase And Activator Protein-1 Signaling During Periodontal Inflammation, Fang-Yu Fan, Thi Thuy Tien Vo, Hsuan Kuo, Chien-Fu Tseng, Wei-Ning Lin, Chia-Yu Wu, Yang-Che Wu, Chuen-Mao Yang, Li-Der Hsiao, I-Ta Lee Jan 2026

Endothelin-1 Drives Cyclooxygenase-2 And Prostaglandin E2 Expression In Osteoblasts Through Mitogen-Activated Protein Kinase And Activator Protein-1 Signaling During Periodontal Inflammation, Fang-Yu Fan, Thi Thuy Tien Vo, Hsuan Kuo, Chien-Fu Tseng, Wei-Ning Lin, Chia-Yu Wu, Yang-Che Wu, Chuen-Mao Yang, Li-Der Hsiao, I-Ta Lee

Journal of Dental Sciences

Background/purpose: Endothelin-1 (ET-1) has been implicated in inflammatory tissue responses, but its role in osteoblast-mediated inflammation during periodontal inflammation remains unclear. This study investigated whether ET-1 induces cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) release in osteoblasts and explored the underlying signaling mechanisms.

Materials and methods: Murine osteoblast-like MC3T3-E1 cells were stimulated with ET-1. COX-2 protein and mRNA expression, promoter activity, and PGE2 release were assessed by Western blotting, real-time RT-PCR, luciferase reporter assay, and ELISA, respectively. Pharmacological inhibitors and siRNA knockdown were used to examine the roles of ETA/ETB receptors, Gq …


Cephalometric And Soft Tissue Determinants Of Esthetic Outcomes After Single-Jaw Mandibular Setback Surgery In Skeletal Class Iii Patients: A Retrospective Study, Chun-Te Ho, You-Ru Chen, Tsui-Hsien Huang, Jnug-Chun Yeh, Tzu-Yu Peng, Chia-Tze Kao Jan 2026

Cephalometric And Soft Tissue Determinants Of Esthetic Outcomes After Single-Jaw Mandibular Setback Surgery In Skeletal Class Iii Patients: A Retrospective Study, Chun-Te Ho, You-Ru Chen, Tsui-Hsien Huang, Jnug-Chun Yeh, Tzu-Yu Peng, Chia-Tze Kao

Journal of Dental Sciences

Background/purpose: Orthognathic surgery is an effective treatment for skeletal Class III malocclusion; however, the relative influence of skeletal and soft tissue variables on postoperative esthetic outcomes remains unclear. This study aimed to evaluate the relationships among cephalometric parameters, soft tissue changes, and esthetic outcomes following single-jaw mandibular setback surgery.

Materials and methods: A retrospective study was performed on 258 adult patients with skeletal Class III malocclusion subspinale-nasion-supramentale (ANB) angle < 0° who were treated between 2016 and 2021. Patients were divided into three groups: bilateral vertical ramus osteotomy (BVRO) group (n = 99), genioplasty alone group (n = 30), and BVRO plus genioplasty group. (n = 129). Cephalometric and …


Isoliquiritigenin Represses The Pro-Fibrotic Tgf-Β/Smad2 Signaling And Nuclear Enriched Abundant Transcript 1 (Neat1) In Oral Submucous Fibrosis, Chi-Shan Tseng, Shih-Min Wang, Yi-Wen Liao, Her-Hsiung Huang, Cheng-Chia Yu, Yicyuan Chen Jan 2026

Isoliquiritigenin Represses The Pro-Fibrotic Tgf-Β/Smad2 Signaling And Nuclear Enriched Abundant Transcript 1 (Neat1) In Oral Submucous Fibrosis, Chi-Shan Tseng, Shih-Min Wang, Yi-Wen Liao, Her-Hsiung Huang, Cheng-Chia Yu, Yicyuan Chen

Journal of Dental Sciences

Background/purpose: Isoliquiritigenin (ISL) has shown anti-fibrotic potential in several organ systems, but its effects on oral submucous fibrosis (OSF) remain unclear. This study investigated whether ISL attenuates myofibroblast activities in buccal mucosal fibroblasts (BMFs) from OSF patients by modulating TGF-β/Smad2 signaling and the long non-coding RNA NEAT1.

Materials and methods: Primary normal BMFs and fibrotic BMFs (fBMFs) were isolated from human buccal mucosa, and cell viability, collagen gel contraction, migration, and wound closure were examined after ISL treatment with or without arecoline. TGF-β1 secretion was quantified, while protein expression of phosphorylated Smad2, COL1A1, and α-SMA was analyzed, and …


Dual-Layer Biphasic Calcium Phosphates/Tantalum Pentoxide Coating On Titanium For Concurrent Biocorrosion Resistance And Enhanced Biocompatibility, Ying-Sui Sun, Kai-Yi Lin, Wei-Cheng Chen, Her-Hsiung Huang Jan 2026

Dual-Layer Biphasic Calcium Phosphates/Tantalum Pentoxide Coating On Titanium For Concurrent Biocorrosion Resistance And Enhanced Biocompatibility, Ying-Sui Sun, Kai-Yi Lin, Wei-Cheng Chen, Her-Hsiung Huang

Journal of Dental Sciences

Background/purpose: Titanium (Ti) dental implants must resist biocorrosion while maintaining biocompatibility. This study developed a dual-layer biphasic calcium phosphates/tantalum pentoxide (BCPs/Ta₂O₅) coating on Ti to improve both biocorrosion resistance and biological performance.

Materials and methods: A dense Ta₂O₅ inner layer was fabricated via a hydrolysis–condensation process to act as a corrosion barrier. Subsequently, a porous BCPs outer layer was deposited by electrochemical cathodic deposition to provide a bioactive interface. Surface morphology, functional groups, crystalline structure, wettability, surface free energy, coating thickness and nanostructure, protein adsorption, and in vitro bioactivity were characterized. Biocorrosion behavior was evaluated using polarization curve measurements in …


Developing Anti-Inflammatory Mineral Trioxide Aggregate As Dental Implant Crown Cement To Reduce Peri-Implantitis Incidence, Yung-Fu Hsu, Sea-Fue Wang, Yi-Le Liao, Chih-Sheng Lin, Ssu-Chi Chen, Sheng-Yang Lee, Wei-Chun Lin Jan 2026

Developing Anti-Inflammatory Mineral Trioxide Aggregate As Dental Implant Crown Cement To Reduce Peri-Implantitis Incidence, Yung-Fu Hsu, Sea-Fue Wang, Yi-Le Liao, Chih-Sheng Lin, Ssu-Chi Chen, Sheng-Yang Lee, Wei-Chun Lin

Journal of Dental Sciences

背景/目的:牙周組織周圍的牙科樹脂黏固劑殘留是植體周圍炎的原因之一。嚴重病例可能導致植體鬆動或脫落。因此,本研究旨在對礦物三氧化物聚集體(MTA)進行改性,使其成為一種抗發炎的牙科植體冠黏固劑(ICC)。

材料與方法:本研究評估了去離子水溶液(Daq)、羥基磷灰石溶液(Haq)和氯化鈣溶液(Caq)對ICC凝固時間、抗壓強度、黏結強度和生物相容性的影響。以單因子變異數分析(ANOVA)檢定各實驗組間的差異( P < 0.05)。

結果:表面微觀結構分析表明,添加Haq和Caq有助於ICC顆粒間的結合。表面元素分析表明,添加Haq增加了Ca離子含量。凝固時間結果表明,與Daq相比,Caq和Haq分別使最終凝固時間縮短了46.5%和34.7%( P < 0.05)。 Caq的抗壓強度分別比Daq和Haq高35.1%和13.4%( P < 0.05)。三種ICC組的黏接強度結果表明,樹脂黏接劑的效果相同( P > 0.05)。生物相容性和清除活性測試表明,ICC優於樹脂黏接劑。

結論: ICC與Caq合併使用可縮短凝固時間、提高抗壓強度、增強生物相容性並降低發炎發生的可能性。因此,ICC與Caq聯合使用可作為牙科樹脂黏固劑的替代方案。


Antisense Oligonucleotides-Mediated Rescue Of The Amelx Splicing Defects, Eui-Sic Cho, Youn Jung Kim, Figen Seymen, Mine Koruyucu, Jan C.-C. Hu, James P. Simmer, Jung-Wook Kim Jan 2026

Antisense Oligonucleotides-Mediated Rescue Of The Amelx Splicing Defects, Eui-Sic Cho, Youn Jung Kim, Figen Seymen, Mine Koruyucu, Jan C.-C. Hu, James P. Simmer, Jung-Wook Kim

Journal of Dental Sciences

Background/purpose: Amelogenesis imperfecta (AI) is a group of rare, inherited disorders characterized by abnormal enamel formation. While identifying the genes and mutations that cause the disease is important, understanding its molecular pathogenesis is essential to developing precision and personalized medicine, which aim to stop disease onset, slow its progression, and provide a range of treatment options. Previously, we identified mutations that affect the conserved alternative splicing of the AMELX gene, leading to the inclusion of normally skipped exon 4 and resulting in a characteristic AI phenotype.

Materials and methods: HEK293 cells were grown on cell culture dishes …


A Comprehensive Analysis And Sex-Related Differences In Root And Root Canal Anatomy In The Taiwanese Population, Ho-Sheng Chiang, Wei-Cheng Lee, Ying-Wu Chen, Ling-Yu Kung, Kuei-Yuan Chen, Ren-Yeong Huang, Yi-Shing Shieh, Yu-Chiao Wu Jan 2026

A Comprehensive Analysis And Sex-Related Differences In Root And Root Canal Anatomy In The Taiwanese Population, Ho-Sheng Chiang, Wei-Cheng Lee, Ying-Wu Chen, Ling-Yu Kung, Kuei-Yuan Chen, Ren-Yeong Huang, Yi-Shing Shieh, Yu-Chiao Wu

Journal of Dental Sciences

Background/purpose: Root canal morphology exhibits substantial anatomical variation influenced by ethnicity and sex, which may complicate endodontic treatment if unrecognized. This study aimed to comprehensively evaluate root and root canal configurations in a Taiwanese population using cone-beam computed tomography (CBCT) and to investigate sex-related differences in canal anatomy.

Materials and methods: CBCT scans from 802 patients treated between 2022 and 2024 were retrospectively analyzed. A total of 18,578 teeth met the inclusion criteria. Root canal configurations were assessed for every root using Vertucci’s classification, and C-shaped canals were further categorized based on morphology. Sex-related differences were analyzed using chi-square tests. …


Optical Properties Of Conventional And High-Translucency Zirconia Ceramics And Their Effects On Resin Cement Polymerization, Chia-Ling Li, Ping-Ju Chen, Jui-Che Lin, Shu-Fen Chuang Jan 2026

Optical Properties Of Conventional And High-Translucency Zirconia Ceramics And Their Effects On Resin Cement Polymerization, Chia-Ling Li, Ping-Ju Chen, Jui-Che Lin, Shu-Fen Chuang

Journal of Dental Sciences

Background/purpose: Adequate polymerization of resin luting cements is essential for durable bonding in zirconia restorations. However, variations in zirconia microstructure and composition may influence translucency and light transmittance, thereby affecting resin cement polymerization. This study aimed to investigate the optical properties of conventional and high-translucency zirconia ceramics and their effects on resin cement polymerization.

Materials and methods: Six zirconia ceramics were evaluated: CerconBase, CerconHT, and VitaHT (3Y-TZP); VitaST (4Y-PSZ); and CerconXT and VitaXT (5Y-PSZ). Disk specimens (0.5 and 1.0 mm thick) were fabricated and sintered. Grain size and elemental compositions were analyzed using scanning electron microscopy and energy-dispersive X-ray …


Spatially Resolved Transcriptomics Identifies Epithelial-Specific Oncogenic Signaling Networks In Ameloblastoma, Chih-Huang Tseng, Shohei Yoshimoto, Kai-Feng Hung, Pei-Hsuan Lu, Yi-Ping Wang, Julia Yu-Fong Chang Jan 2026

Spatially Resolved Transcriptomics Identifies Epithelial-Specific Oncogenic Signaling Networks In Ameloblastoma, Chih-Huang Tseng, Shohei Yoshimoto, Kai-Feng Hung, Pei-Hsuan Lu, Yi-Ping Wang, Julia Yu-Fong Chang

Journal of Dental Sciences

Background/purpose: Ameloblastoma is a benign odontogenic tumor characterized by locally aggressive growth and a high recurrence rate. Although recurrent mutations such as BRAF V600E have been identified, the epithelial-specific molecular mechanisms underlying tumor initiation and invasion remain incompletely defined. Previous transcriptomic studies have been limited by stromal contamination and lack of spatial resolution.

Materials and methods: An integrative transcriptomic strategy was applied, combining bulk RNA sequencing of fresh ameloblastoma and dental follicular tissues, RNA sequencing of primary cultured ameloblastoma epithelial cells and dental follicular epithelial cells, and spatial transcriptomic profiling of formalin-fixed, paraffin-embedded ameloblastoma specimens.

Results: Differential expression and functional …