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Articles 111361 - 111362 of 111362
Full-Text Articles in Entire DC Network
Alzheimer's Disease Heterogeneity And Co-Pathologies: Defining Novel Targets, Biomarkers, Modalities, And Research Methodologies, Malú Gámez Tansey, Jorge J Llibre-Guerra, Suzanne E Schindler
Alzheimer's Disease Heterogeneity And Co-Pathologies: Defining Novel Targets, Biomarkers, Modalities, And Research Methodologies, Malú Gámez Tansey, Jorge J Llibre-Guerra, Suzanne E Schindler
2020-Current year OA Pubs
Alzheimer's disease (AD) is a biologically heterogeneous condition with vascular, proteinopathic, metabolic, and immune processes jointly shaping its clinical expression, trajectory of progression, and response to therapeutic intervention. Common AD co-pathologies such as cerebral amyloid angiopathy, Lewy body pathology, α-synuclein, and transactive response DNA-binding protein of 43 kDa (TDP-43)/limbic-predominant age-related TDP-43 encephalopathy are also increasingly connected with cognitive decline and therapeutic response. Significant advances in biomarkers, including seed amplification assays, proteomic signatures, and emerging positron emission tomography tracers bolster the field's understanding of a biological staging model and discovery of previously unrecognized co-pathologies. The Fall 2025 Alzheimer's Association Research Roundtable …
Understanding Processes Involved In Firefighter/Ems Resilience And Suicidality: A Mixed Methods Analysis, Benjamin H. Barnette
Understanding Processes Involved In Firefighter/Ems Resilience And Suicidality: A Mixed Methods Analysis, Benjamin H. Barnette
Clinical Psychology Dissertations
First responders in the fire service and emergency medical services (EMS) are the subject of research focused on career suicide risk, occupational hazards, and psychological resilience; however, the nature of the relationships between these three variables is not well understood. This study employed a mixed methods design to test the moderating role of resilience in the relationship between the severity of critical incident exposure and two distinct processes involved in suicidality: suicidogenic cognitions and the acquired capability for suicide. A total of 248 eligible participants with experience in firefighting and/or EMS responded to an online survey. Psychological resilience was negatively …