Digital Commons Network^™

Assessment Of In-Frame Indel Variants In An Unsolved Cohort Of Inherited Retinal Diseases Using Machine Learning, David E Rauch, Meng Wang, Muhammad Jafar Hussain Hafiz, Daniel C Brock, Yumei Li, Molly Marra, Mark E Pennesi, Paul Yang, Everett Lesley, Irma Lopez, Robert Koenekoop, Edward Ryan Collantes, Joanne Bolinao, Rui Chen

Faculty, Staff and Students Publications

The standard for in silico pathogenicity prediction of in-frame insertions and deletions (indels) is less established compared to other types of variations. We aimed to systematically assess the performance of in silico machine learning (ML) tools on a patient cohort with inherited retinal diseases (IRDs). The performance of four ML tools (CADD, FATHMM-indel, VEST4, and MetaRNN-indel) was compared. Among them, MetaRNN-indel showed the best overall results. MetaRNN-indel was then applied to 1013 unsolved IRD patients, identifying two likely pathogenic causal variants in two unrelated IRD patients by confirming clinical phenotypes. Hence, our findings indicate that reliable prediction of the pathogenicity …

Identification Of Cand1 As A Dna-Dependent Protein Kinase-Regulated Coactivator Of Androgen Receptor And The Arv7 Splice Variant, Ross A Hamilton, Basil Paul, Ping Yi, Kimal Rajapakshe, Anil K Panigrahi, Sandra L Grimm, Cristian Coarfa, Anna Malovannaya, Nancy L Weigel, David M Lonard, Charles E Foulds

Faculty, Staff and Students Publications

ARv7, the most prevalent androgen receptor (AR) variant in castration-resistant prostate cancer, lacks the ligand binding domain (LBD), rendering it resistant to LBD-targeted therapies. Identifying new therapeutic targets requires defining the coregulators and associated regulatory enzymes that govern AR and ARv7 transcriptional activity. Here, we have developed a cell-free DNA pulldown assay employing androgen response elements (AREs) to isolate and characterize the AR- and ARv7-associated coregulator complexes formed on DNA. Mass spectrometry analyses of ARE DNA pulldowns revealed previously unrecognized AR and ARv7 associating coregulators, such as cullin-associated NEDD8-dissociated protein 1 (CAND1), in addition to previously known coregulators. ARv7 showed …

Therapeutic Potential Of Hookworm Proteins In Promoting Regulatory Immune Responses To Modulate Trypanosoma Cruzi Induced Liver Inflammation And Oxidative Stress, Maria Jose Villar, Cristina Poveda, Bin Zhan, Maya Gonsoulin, Kathryn M Jones

Faculty, Staff and Students Publications

Background: Chronic Trypanosoma cruzi infection causes significant liver pathology, and current antiparasitic treatments often worsen hepatic damage. Hookworm-derived proteins have shown immunomodulatory effects in inflammatory diseases, including T. cruzi-induced myocarditis.

Objective: This study evaluates recombinant hookworm proteins AIP-1 and AIP-2 for treating liver inflammation in a murine model of chronic Chagas disease (CD).

Methods: Female BALB/c mice infected with T. cruzi were treated with AIP-1 or AIP-2 (1 mg/kg) for seven days. Controls were untreated or received aspirin (25 mg/kg) for 14 days. Liver tissues were analyzed for parasite burden (quantitative polymerase chain reaction - qPCR), histopathology (H&E, Picrosirius Red), …

Inclusive Psychology Pedagogy Is Linked To Increased Belonging And Reduced Prejudice Toward Consensually Non-Monogamous Relationships, Rose Bern, Rachel Dinero, Kate Linenbach, Amy Moors

Psychology Faculty Articles and Research

Students enrolled in an elective psychology course entitled Relationship Science, which emphasized inclusive curricula focused on relationship diversity, completed pre- and postcourse assessments of attitudes toward consensually nonmonogamous (CNM) relationships, relationship skills (e.g., constructive communication), and classroom belonging. Given the established literature on lesbian, gay, bisexual, transgender, queer+-inclusive pedagogy, attitudes toward lesbian, gay, bisexual, transgender, queer+ individuals were also measured. Comparisons of pre- and postcourse assessments revealed significant reductions in stigma toward individuals engaged in CNM, alongside increased acceptance of CNM relationships more broadly. Students also reported increases in relationship skills and classroom belonging over the course of the …

Empowering Change From The Ground Up: Women’S Entrepreneurship In Sub-Saharan Africa’S Informal Sector, Rita Abban, Esi A. Elliot

International Business and Entrepreneurship Faculty Publications

Women’s entrepreneurship in Sub-Saharan Africa (SSA) is a critical driver of socio-economic development, within the informal sector where women enterprises are concentrated. Despite substantial contributions, structural and institutional barriers impede the formalization of these businesses, curbing their economic impact. This study examines how women entrepreneurs in Ghana and SSA navigate informal practices to achieve economic mobility. Employing a systematic literature review - PRISMA framework, the research synthesizes key themes including entrepreneurial capacity, sustainability, intellectual property, and institutional support. A comparative lens incorporating Rwanda and South Africa reveals Ghana’s high rate of female entrepreneurship, predominance of informal trade, and socio-cultural dynamics …

A Firm’S Operational Risk: Data Set And Empirical Evidence, Vivek Astvansh, Joseph J. Simpson

International Business and Entrepreneurship Faculty Publications

Problem definition: A firm’s stakeholders would benefit from a quantitative measure of the managerial disclosure of its operational risk and the implications of this disclosure. However, a quantitative and scalable measure of a firm’s disclosed operational risk is unavailable. Thus, the firm’s stakeholders remain unaware of its disclosed operational risk and the risk’s implications. Methodology/results: U.S. law requires a public firm to textually disclose its operational and nonoperational risks in Item 1A of its annual report (i.e., Form 10-K). We train 64 transformer models on U.S. public firms’ Item 1A text to score 131,920 firm-years (16,959 firms, 2005 to 2024) …

Making Words Count: Computational Linguistics In Management Research, Joseph J. Simpson, Richard A. Hunt, David M. Townsend, Judy Rady, Elham Asgari, Mohammad Rady, Daniel J. Beal

International Business and Entrepreneurship Faculty Publications

In recent years, a rapidly growing number of management scholars are using computational linguistics (CL) to analyze vast corpora of naturally occurring organizational language. Yet the rapid adoption of CL methods has outpaced the development of shared standards for linking theoretical constructs, linguistic data, and computational measurement. We synthesize 353 articles published in leading management journals for 2013–2025, identifying four recurring challenges shaping the credibility of CL-based research: misalignment between constructs and textual corpora, unnecessary model complexity, the opacity of large language model workflows, and insufficient transparency in reporting. Building on these patterns, we develop four integrative design principles—construct-language fit, …

Beyond Exposure: Belief In Police Misinformation, Media Consumption, And Support For Policing Reform, Linda Balcarova Dietz

Electronic Theses & Dissertations (2024 - present)

In today’s post-truth era, misinformation has become a central feature of modern society. While not a new phenomenon, the 2024 Presidential election demonstrated what a serious problem it represents, as public perceptions were driven more by information they received (true or false) than by objective social conditions. Policing is one of the most debated topics in criminal justice, dividing public opinion along partisan and racial lines. Studies show that the information people receive about police shapes their attitudes, yet criminologists have largely overlooked how misinformation may influence those views. This dissertation fills that gap by experimentally testing how exposure to …

Platelet Extravasation In The Microvasculature: An Under-Appreciated Role For Platelets, Justin A Courson, Vahid Afshar-Kharghan, Alan R Burns, Rolando E Rumbaut

Faculty, Staff and Students Publications

In recent years, evidence has accumulated highlighting the presence and role of platelet extravasation - wherein platelets accumulate in tissue parenchyma - at a variety of sites throughout the body. While platelets are traditionally known for their roles in hemostasis and thrombosis, it is evident that platelets are potent mediators of inflammation across an array of physiological and pathological contexts. While anucleate and small in size, platelets contain a rich diversity of molecules in their granules capable of modulating cell proliferation, tissue repair, and a host of immune responses. There is growing evidence that platelet extravasation out of the vascular …

Using Medication Pass Analysis To Examine Longitudinal Changes In Va Inpatient Nurse Staffing And Workload Before And Through The Covid-19 Pandemic: 2019-2022, Melissa K Knox, Chase S Eck, Lynette Dorsey, Paras D Mehta, Christine Yang, Laura A Petersen

Faculty, Staff and Students Publications

Background: The COVID-19 pandemic resulted in extended disruption to the health care system. National-level data-driven comparisons of inpatient nurse staffing and workload before and during the pandemic have been limited.

Objectives: Assess the extent to which registered nurse (RN) staffing and workload changed from prepandemic levels in a national integrated health care system.

Research design: Longitudinal descriptive analysis. Medication pass analysis using bar code medication administration data for the peak-time medication pass (PTM) assessing year-over-year changes from 2019 to 2022. To assess significance of year-over-year changes in means we used the Welch 2-sample t test.

Subjects: Staff (N=42,999) administering PTM …

Ptpn1 Regulation Via Ybx1-Ptbp1 Interaction Promotes Fibroblast Activation And Fibrotic Remodeling In The Lung, Huibing Liu, Cong Xia, Yingying Zhang, Yulong Gan, Lianhui Cheng, Xuqian Wang, Airu Chang, Wenyu Zhao, Bin Li, Yaxuan Wang, Yajun Li, Ivan Rosas, Juntang Yang, Guoying Yu, Lan Wang

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial pneumonia of unknown etiology. Its pathogenesis involves complex multicellular interactions and signaling pathways, with fibroblast-to-myofibroblast transition (FMT) being critical for fibrogenesis. Although the transcription factor Y-box binding protein 1 (YBX1) regulates processes such as cell proliferation, transcription, translation, and DNA repair, its role in IPF remains undefined. Here, we demonstrate that YBX1 overexpression significantly promotes transforming growth factor-β1 (TGF-β1)-induced pulmonary FMT, leading to substantially increased extracellular matrix (ECM) deposition in primary human (PHLFs) and mouse (PMLFs) lung fibroblasts. Conversely, YBX1 inhibition markedly suppresses TGF-β1-driven aberrant fibroblast migration and activation. Mechanistically, YBX1 …

Falling For Mobility, Wendy Savercool Dnp, Rn, Crni, Ocn, Fab, Ian Heck Msn, Rn, Nea-Bc, Kayla Rosica Msn, Rn, Ne-Bc, Medsurg-Bc

Patient Care Services / Nursing

No abstract provided.

Helping Nurses To ‘Get Their Good Work Out There’, Lori Grischott Msn, Rn, Nea-Bc, Npd-Bc, Rnc-Ob, Lauren Souchak Msn, Rn, Bea-Bc

Patient Care Services / Nursing

No abstract provided.

Immune-Mediated Diarrhea And Colitis With Normal Biochemical, Endoscopic And Histologic Findings: A Retrospective Study, Malek Shatila, Sharada Wali, Carolina Colli Cruz, Kei Takigawa, Andres Caleb Urias Rivera, Kian Abdul-Baki, Tanvi Gupta, Elliot Baerman, Linfeng Lu, Irene Jeong-Ah Lee, Raakhi Menon, Hamza Salim, Andrew Sullivan, Varun Vemulapalli, Cristina Natha, Ayesha Khan, Krishnavathana Varatharajalu, Stephane Champiat, Kerry L Reynolds, Lucy B Kennedy, Katy Tsai, Anusha Shirwaiker Thomas, Yinghong Wang

Faculty, Staff and Students Publications

Background: Immune-mediated diarrhea and colitis (IMDC) due to checkpoint inhibition infrequently presents with normal stool biomarkers and no endoscopic or histologic evidence of inflammation. Little is known about the treatment needs and outcomes of this subset of patients. We aimed to describe this entity and clarify the role of immunosuppressive treatments in its management.

Method: This was a single-center, retrospective study of patients treated with immune checkpoint inhibitors who developed clinical symptoms of IMDC, with no evidence of inflammation based on fecal calprotectin or endoscopic/histologic evaluation, between January 2010 and February 2024.

Results: Of 1151 patients with IMDC, 131 (11.4%) …

Interdisciplinary Swiss Consensus Recommendations For Follow-Up After Radical Cystectomy And Trimodal Treatment For Muscle-Invasive Bladder Cancer, Ernest Kaufmann, Stefanie Aeppli, Andres Affentranger, Nicolas Arnold, Winfried Arnold, Fabian Aschwanden, Panagiotis Balermpas, Jörg Beyer, Uwe Bieri, Joost Boormanns, Richard Cathomas, Berardino De Bari, Marco Dressler, Daniel S Engeler, Andreas Erdmann, Andrea Gallina, Silvia Gomez, Matthias Guckenberger, Thomas Herrmann, Thomas Hermanns, Ilaria Lucca, Hubert John, Thomas Matthias Kessler, Jan Klein, Mohamed Laouiti, David Lauffer, Seth Paul Lerner, Agostino Mattei, Michael Müntener, Daniel Nguyen, Philipp Niederberger, Alexandros Papachristofilou, Lukas Prause, Paul Martin Putora, Karsten Reinhardt, Emanuela Salati, Philippe Sèbe, Mohamed Shelan, Silvan Sigg, Räto Thomas Strebel, Arnoud Jan Templeton, Ursula Vogl, Marian Severin Wettstein, Stephen Wyler, Deborah Zihler, Thomas Zilli, Daniel Zwahlen, Beat Roth, Christian Daniel Fankhauser

Faculty, Staff and Students Publications

Introduction: Radical cystectomy or trimodal therapy are treatment options for non-metastatic bladder cancer. However, there is limited evidence guiding post-treatment follow-up regimens, resulting in variations in care.

Objective: A Swiss consensus meeting aimed to identify gaps in follow-up strategies and subsequently tailoring follow-up protocols after curative treatment for bladder cancer.

Methods: A consensus meeting including participants from urology, oncology, radiation oncology, neuro-urology, international advisors, and patient representatives was held. 19 pre-formulated questions addressing follow-up duration, frequency, and modalities after radical cystectomy or trimodal therapy for bladder cancer were discussed and voted by participants.

Results: 42 experts from 22 institutions participated …

Commencement Program 2026, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2026 Events of Commencement

5 | The Academic Procession

6 | Institutional Administration

7 | Board of Trustees

8 | Significance of Academic Regalia

9 | University History Highlights

11 | Loma Linda University Health and Loma Linda University Honorees

The Programs, The School Honorees, and The Speakers

24 | School of Medicine

43 | School of Pharmacy

54 | School of Dentistry

72 | School of Public Health

85 | San Manuel Gateway College

91 | School of Allied Health Professions — Allied Health Studies, Cardiopulmonary Sciences, Clinical Laboratory Science, …

Elementary Teachers' Perceptions On Mtss, Inclusion And Instructional Pedagogy, Sarah Mccusker

All Capstone Projects

The purpose of the study was to examine elementary teachers’ perceptions of the multi-tiered system of support (MTSS) implementation process, their understandings of inclusion, and the ways these beliefs informed their pedagogy. To gain deeper insight into these dynamics, a phenomenological approach was employed, in which elementary educators were invited to participate in interviews that focused on the MTSS process in their school contexts. Findings revealed teachers’ interpretations of inclusive classrooms, their perceptions of MTSS frameworks, and the strategies they used to address students’ academic and behavioral needs while recognizing individual strengths. Teachers shared their beliefs about students who do …

Non-Congenital Hsv-1 Keratitis In An Immunocompetent 9-Month-Old Infant, Caleb A Casanova, Stephanie Trejo Corona, Stephen F Pflugfelder

Faculty, Staff and Students Publications

Isolated, non-congenital herpes simplex virus type 1 (HSV-1) keratitis in immunocompetent infants is exceedingly rare and may be easily misdiagnosed, leading to delays in appropriate antiviral therapy. This case is unique in that it describes HSV-1 keratitis in a healthy 9-month-old infant presenting without systemic illness, initially treated as bacterial conjunctivitis. The patient presented with unilateral eye pain, redness, and corneal opacification. Subsequent evaluation revealed HSV-1 keratitis, and the patient was treated with intravenous acyclovir in combination with topical moxifloxacin and topical ganciclovir, resulting in complete resolution of symptoms within one week. This case adds to the limited literature on …

Point-Of-Care Ultrasound Foundations In Physics And Image Acquisition: An Innovative Hands-On Active Learning Workshop, Cherie Tator, Saul Flores, Alan Riley, Kiyetta Alade

Faculty, Staff and Students Publications

Introduction: We developed an innovative, active learning workshop to introduce foundations of point-of-care ultrasound (POCUS) physics and instrumentation. The workshop design aimed to reduce cognitive load and encourage learner-centered engagement through hands-on exploration that reinforces key principles and connects theory to practice.

Methods: First-year medical students participated in small-group, student-driven exercises to explore POCUS machine controls, transducers, and image acquisition skills. Each group was supported by a faculty member to guide activities and ensure accuracy. Students scanned pickles, hard-boiled eggs, and olives with pits; these items were selected for their low cost, sonographic characteristics, and recognizability. Later in the semester, …

How Do African American Alumni At Private Predominantly White Institutions Describe And Interpret The Influence Of Culturally Responsive Support Spaces On Their Sense Of Belonging, Academic Persistence, And Long-Term Professional Development With The Institutional Context, Karen Williams-Blackman

All Student Theses and Dissertations

This qualitative case study examined how African American alumni at a private, predominantly White institution (PWI) in the Midwest described and interpreted the influence of culturally responsive support spaces on their sense of belonging, academic persistence, and long-term professional development. Culturally responsive support spaces are defined as environments that affirm identity, provide protection, and foster community, offering relational and cultural validation beyond traditional institutional diversity or compliance-based initiatives. Guided by Critical Race Theory (CRT) and Validation Theory (VT), this research examined how alumni interpreted their interactions with these support spaces and how such experiences influenced their academic trajectories and enduring …

Linking Social Entrepreneurship To Crime Reduction Among Young African Americans In Chicago’S South And West Sides, Grady C. Wheaton Jr.

All Student Theses and Dissertations

This study examined community members’ perceptions of social entrepreneurship as an employment-centered strategy for addressing youth violence among African Americans on Chicago’s South and West Sides. The study was guided by the following research question: Can social entrepreneurship be leveraged to reduce youth violence among African Americans on Chicago’s South and West Sides, as perceived by community members? Using Fillmore Laundry, a healthcare linen-processing social enterprise located in North Lawndale, as a case example, this quantitative, cross-sectional study collected survey data from 99 eligible community members recruited through community-based partnerships. The survey assessed perceived youth- and community-level program benefits, evaluations …

Exploring Management Strategies To Reduce Workplace Violence: Perceptions Of Illinois Healthcare Professionals, Mary Mack

All Student Theses and Dissertations

This qualitative study examined how managers of nonprofit healthcare facilities in the Chicago metropolitan area implement strategies to reduce workplace violence, what these strategies are and how they are carried out, and what organizational factors facilitate or impede their implementation. Semi-structured interviews were conducted with seven healthcare professionals in management or safety-oriented roles across seven facilities, purposefully sampled through the researcher's professional network. Findings revealed four recurring patterns across the sample. Prevention infrastructure was installed reactively, following specific triggering incidents rather than anticipating documented risk. Facilities consistently favored lower-cost mitigation measures over more resource-intensive prevention strategies. Reliance on short-tenure contract …

The Lived Experiences Of Counselors Working With Adults Suffering From Major Depression In Nursing Home Facilities. A Qualitative Phenomenological Study Grounded In A Wellness Perspective, Melissa Arguelles De Jesus

All Student Theses and Dissertations

There is new knowledge that major depression disorder (MDD), specifically, is one of the most encountered mental health diagnoses assigned among older adult residents who live in a nursing home (NH) setting (Matos Queiros et al., 2021). Antidepressants are known to be the main improvement factor and optimal management for treating depression; however, consideration for other treatment modalities continues to be explored (Voineskos et al., 2020). Wellness counseling, which is known to foster a person-centered approach, may help NH residents develop coping skills to enhance both overall welfare and everyday functioning across multiple domains. Residents can be empowered as decision …

Works Progress Administration (Wpa) Inventories Of Church Records - Accession 410, Works Progress Administration, Church Records, South Carolina Historical Society

Manuscript Collection

These records were microfilmed by the South Carolina Historical Society through the cooperation of the South Caroliniana Library at the University of South Carolina, Columbia, under a grant from the South Carolina Committee for the Humanities as part of the grant titled “Genealogy, Community & Identity: Finding Local Roots.” These records represent the efforts of WPA field researchers who collected information on the history and records of approximately 2,500 South Carolina Churches in the late 1930s, including black congregations. The records include work forms, typed reports, newspaper clippings and short histories. The information pertains to physical descriptions of church buildings …

School-Level Gaps In Mmr Coverage As The Fuel For Measles Outbreaks, Meagan C Fitzpatrick, Chad R Wells, Abhishek Pandey, Lamia Ayaz, Peter J Hotez, Seyed M Moghadas, Alison P Galvani

Faculty, Staff and Students Publications

No abstract provided.

Cerebellar Deep Brain Stimulation Rescues Purkinje Cell Mitochondrial Density In A Genetic Mouse Model Of Cerebellar Ataxia, Lauren N Miterko-Myers, Lauren E Peacoe, Lita Duraine, Zhongyuan Zuo, Roy V Sillitoe

Faculty, Staff and Students Publications

Deep brain stimulation (DBS) improves motor function in a growing list of movement diseases including Parkinson's disease, dystonia, and tremor. There is evidence that DBS may also be effective in ataxia. It is not known why DBS is effective, but modulating cell activity and conferring neuroprotection are hypothesized to underlie its benefits. Understanding the effects of DBS on neurons is paramount to extending its clinical use in the treatment of various motor and non-motor diseases. Here, we stimulated the cerebellum of Car8 waddles (Car8wdl) mice, given the cerebellum's important role in ataxia pathophysiology. Using transmission electron microscopy, we tested the …

Flows, Financing Decisions, And Institutional Ownership Of The U.S. Equity Market, Alon Brav, Dorothy S. Lund, Lin Zhao

Faculty Scholarship

This Article analyzes the relationship between flows to institutional investment managers, corporate financing decisions, and institutional ownership of U.S. public equity. In so doing, it provides new evidence about the drivers of institutional investor growth in equity ownership over the past two decades. Contrary to conventional narrative, we find that equity capital flows into the “Big Three” investment managers have slowed in recent years, with substantial differences between each institution. We also present a framework to understand how fund characteristics and corporate actions such as stock buybacks and equity issuances combine to shape the evolution of institutional ownership, including that …

Campus Crises And The Limits Of Title Vi, Suzanne B. Goldberg, Olatunde C.A. Johnson

Faculty Scholarship

This Piece examines the deployment of Title VI of the Civil Rights Act of 1964 as a mechanism for regulating campus conflict following the 2023 to 2024 campus protests and seeks to reset the discourse in light of the statute’s history, doctrine, and role in higher education. Title VI is an important tool for addressing identity-based harassment, epithets, and violence between students, but it is neither designed nor effective as a tool for negotiating clashes between universities’ cornerstone commitments to robust debate and an optimal learning environment for all students. In converting the statute from a source of protection against …

Why Constitutional Argument Matters, Philip C. Bobbitt

Faculty Scholarship

The program for this symposium promised that I would be discussing the “descriptive grammar of constitutional law.” To put my purpose less benignly, I should say that I mean to attack the practice of limiting what I will call “modal analysis” to its descriptive virtues. Part of that attack will be the claim that courts and their commentators should pay closer attention to the modal requirements of the fundamental forms of constitutional discourse, but not because straying from this is a kind of grammatical faux pas. After all, if the system I have urged for constitutional analysis — the system …

Disconsents, Daryl J. Levinson, David E. Pozen

Faculty Scholarship

Consent is an indispensable standard and organizing principle in any liberal legal order that prizes self-directed autonomy, self-identified preferences, and collective agreement. Yet consent’s capacity to advance those values has become increasingly uncertain in a society beset by power imbalances, information asymmetries, and multiple forms of polarization. In this Article, we document how the rise of neoliberalism has led to greater reliance on consent throughout U.S. law, while at the same time leading to greater doubts about its moral efficacy and empirical feasibility. Connecting and generalizing pathologies of consent-based regulation that have been identified within myriad domains, the Article identifies …