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Articles 110581 - 110610 of 110961
Full-Text Articles in Entire DC Network
Regulating Galaxy Growth: Ionized Gas Conditions, Star Formation Histories, And Environmental Effects, Shweta Jain
Regulating Galaxy Growth: Ionized Gas Conditions, Star Formation Histories, And Environmental Effects, Shweta Jain
University of Kentucky Doctoral Dissertations
Understanding galaxy formation and evolution requires tracing how baryons cycle between stars, gas, and the interstellar medium (ISM) across cosmic time. The efficiency of star formation, the buildup of metals, and the regulation of gas inflows and outflows are governed by evolving physical conditions within galaxies and their environments. My thesis investigates how the ionized ISM, star formation histories, and environmental processes have shaped galaxy evolution over the past ∼ 12 Gyr. The primary focus of this work is the evolution of the physical conditions of ionized gas in galaxies, including gas-phase metallicity and ionization state. Using new and archival …
Technology-Facilitated Violence And Abuse: Portrayals And Perceptions, Christina S. Walker
Technology-Facilitated Violence And Abuse: Portrayals And Perceptions, Christina S. Walker
University of Kentucky Doctoral Dissertations
In the past, intimate partner violence (IPV) was primarily perpetrated in person. However, due to new mediated communication technologies and capabilities like social media and artificial intelligence (AI), perpetrators can use this technology for various purposes including subjecting others to violence, harassment, and abuse. Such violence can be a form of IPV and is referred to as technology-facilitated violence and abuse (TFVA). TFVA is becoming increasingly prevalent and is encountered by a staggering percent of women. Furthermore, unlike traditional forms of IPV, even men are subjected to TFVA at increasing and disproportionate rates, particularly male teens.
In the current state …
A Nonlocal Lattice Particle Method For Modeling Hcp Polycrystalline Solids, Di Liu
A Nonlocal Lattice Particle Method For Modeling Hcp Polycrystalline Solids, Di Liu
University of Kentucky Doctoral Dissertations
Polycrystalline materials, composed of individual grains with varying grain size, shape, and crystallographic orientation are widely used in various engineering and industrial applications. Conventional applications of polycrystalline materials rely on the macroscopic performance, and the microstructural features are usually homogenized out. With the advancement of modern technologies and improvement of characterization methods, polycrystalline materials find their applications in meso- and micro-scale systems. At these length scales, the microscopic features including grain boundary characteristics significantly affect the material physical responses. As a result, the conventional continuum mechanics models become problematic, especially for material failure problems where the microstructural features play dominant …
The Power Of A Picture: Building Visual Depictions Of The Eppm Bolstering Sunscreen Application Motivation, Ansley M. George
The Power Of A Picture: Building Visual Depictions Of The Eppm Bolstering Sunscreen Application Motivation, Ansley M. George
University of Kentucky Doctoral Dissertations
This study investigates visual depictions of efficacy skin cancer health risk messages. Using Witte's Extended Parallel Processing Model (EPPM) and existing literature on fear appeals and visual persuasion as a theoretical framework, the study aims to explore how self and response efficacy imagery impacts individuals' perceptions of health risk messages in the context of skin cancer prevention when emphasizing specific principles of design. Formative research was employed via qualitative photo sorts and participants were exposed to an assortment of images depicting efficacy in the context of skin cancer prevention where they discussed why they felt they were or were not …
Multiscale Modeling Of The Thermomechanical Behavior Of Polymeric And Molecular Organic Semiconductors, Kehinde H. Fagbohungbe
Multiscale Modeling Of The Thermomechanical Behavior Of Polymeric And Molecular Organic Semiconductors, Kehinde H. Fagbohungbe
University of Kentucky Doctoral Dissertations
Organic semiconductors, derived from π-conjugated polymers and molecules, enable the development of deformable, stretchable and flexible electronics due to their tunable redox, optical, electronic and mechanical properties. However, an informed understanding of how multi-scale morphological characteristics of the polymeric and molecular semiconductors influence bulk properties that contribute to electronic and optical performance, especially under operational thermal and mechanical stresses, remains incomplete. This lack of understanding poses a challenge to scalability and commercialization of organic electronics. This dissertation develops and deploys computational modeling approaches, particularly atomistic molecular dynamics (MD) simulations, to investigate the multiscale morphological behavior of these synthetic semiconducting materials …
Personality Exceptions: Enhancing Character In Narrative Planners With Internal Memory, Elinor Rubin-Mcgregor
Personality Exceptions: Enhancing Character In Narrative Planners With Internal Memory, Elinor Rubin-Mcgregor
University of Kentucky Doctoral Dissertations
Stories and narratives are powerful tools for forging connections between people, as they induce emotions shared through their audience and help build empathy and understanding through sharing unique perspectives. Interactive stories can do all this and more, as they can be used to better educate and engage their audience. But in such stories, the characters must have consistent personality and human-like emotions in order for the audience to relate to them. Current implementations of personality in interactive narratives either portrays characters with static personality that feel less realistic, or else require a great deal of additional work from the author …
Ayer Y Hoy De España En Guinea Ecuatorial. Construcción De La Colonia Africana Y Sus Consecuencias En La Actualidad A Través De Las Voces Femeninas En La Literatura En Español, Jesús Ponte Bernal
Ayer Y Hoy De España En Guinea Ecuatorial. Construcción De La Colonia Africana Y Sus Consecuencias En La Actualidad A Través De Las Voces Femeninas En La Literatura En Español, Jesús Ponte Bernal
University of Kentucky Doctoral Dissertations
Equatorial Guinea was a Spanish colony until 1968. Despite this, it has never received much attention from the Iberian Peninsula, so its literature and history remain unknown to much of the Spanish-speaking population. This has been due to historical factors, such as the Franco dictatorship, which classified everything related to the African colony as confidential, but also due to the racial exclusion experienced by the Black population throughout history. Generally, only some Equatorial Guinean male authors have managed to carve out a place for themselves in the cultural canon.
This study analyzes eight books whose plots take place in Equatorial …
Non-Invasive Digital Restoration Of Damaged Photographic Film Negatives, Ankan Bhattacharyya
Non-Invasive Digital Restoration Of Damaged Photographic Film Negatives, Ankan Bhattacharyya
University of Kentucky Doctoral Dissertations
Physical restoration of damaged photographic film causes more damage. Also, existing non-invasive digital restoration of film negatives does not produce print-quality optical images. Instead, they produce X-ray projections, which are not the same as optical projections. This thesis addresses these problems and establishes a framework that can digitally restore old, damaged films without the need to open them physically. Virtual Unwrapping is an existing pipeline that has proven itself over the last couple of decades to work on unopenable papyrus scrolls, like the Herculaneum Scrolls. This thesis utilizes the concept of virtual unwrapping to restore damaged photographic film negatives. Due …
Colorectal Cancer Screening In Saudi Arabia: Current Challenges And Future Directions, Abdulrahman A. Aljabri, Abdulrahman G. Alharbi
Colorectal Cancer Screening In Saudi Arabia: Current Challenges And Future Directions, Abdulrahman A. Aljabri, Abdulrahman G. Alharbi
Saudi Medical Journal
Abstract Colorectal cancer has become a major public health concern in Saudi Arabia. It is the most prevalent cancer among men and the third most prevalent among women. Although screening for people aged 45-75 is recommended by national recommendations, screening uptake is still below 10%, and less than 1% of older persons have a colonoscopy. With regional differences that vary from age-standardized rates of 3.2 per 100,000 in Jouf to 21.8 per 100,000 in Riyadh among men, approximately 29% of cases are detected at late stages. Therefore, we assessed the epidemiological, social, and health-related systemic structures preventing effective colorectal cancer …
Magnitude Of Abdominal Solid Organs Injuries Among Patients With Pelvic Fracture At King Abdullah Hospital, Bisha City, Saudi Arabia, Ali Ibrahim Alshehri, Mohammed Jalawi Karkaman, Nawaf Amer Alsoiry, Naif Abdulaziz Alqarni
Magnitude Of Abdominal Solid Organs Injuries Among Patients With Pelvic Fracture At King Abdullah Hospital, Bisha City, Saudi Arabia, Ali Ibrahim Alshehri, Mohammed Jalawi Karkaman, Nawaf Amer Alsoiry, Naif Abdulaziz Alqarni
Saudi Medical Journal
Objective: To access the magnitude of these injuries in patients with pelvic fractures at King Abdullah Hospital, Bisha, Saudi Arabia. Abdominal solid organ injuries are life-threatening and results in adverse health effects particularly to patients with pelvic fracture. Methods: An analytical cross-sectional retrospective hospital-based study that reviewed a total of 236 medical records of patients with abdominal organ injuries and pelvic fractures at King Abdullah Hospital, Bisha, Saudi Arabia. Cleaned data was coded and analyzed with the use of SPSS version 23 to drive key insights. Results: The study comprised of 236 patients in total. Approximately 38 (16.1%) patients had …
Targeted Neonatal Echocardiography And Neonatal Hemodynamics In The Kingdom Of Saudi Arabia: A One-Year Experience In Service Implementation, Abdulaziz Homedi, Kamal Ali Ali, Abdulrahman Almehaid, Mohanned Alrahili, Abdulrahman Mandurah, Mohammed Almahdi, Faisal Alamer, Eman Bazbouz, Shatha Algarni, Atheer Alshehri, Faisal Alsehli, Hanof Bakri
Targeted Neonatal Echocardiography And Neonatal Hemodynamics In The Kingdom Of Saudi Arabia: A One-Year Experience In Service Implementation, Abdulaziz Homedi, Kamal Ali Ali, Abdulrahman Almehaid, Mohanned Alrahili, Abdulrahman Mandurah, Mohammed Almahdi, Faisal Alamer, Eman Bazbouz, Shatha Algarni, Atheer Alshehri, Faisal Alsehli, Hanof Bakri
Saudi Medical Journal
Objective: To evaluate the impact of a newly established targeted neonatal echocardiography (TNE) and Neonatal Hemodynamics consultation service on the assessment and management of neonates. Methods: This is a descriptive retrospective cohort study that included all neonates who underwent TNE consultations in the Neonatal Intensive Care Unit from October 2023 and September 2024. Clinical indications, diagnostic findings, and subsequent management were analyzed. Result: A total of 237 TNE consultations were performed for 105 neonates. The mean gestational age was 29.9 weeks, and the mean birth weight was 1433 grams. On average, 19.8 echocardiographic scans were performed per month. The leading …
Clinical Characteristics And Outcomes Of Patients With Amphetamine Associated Emergency Department Visits At A Tertiary Care Hospital In Riyadh, Saudi Arabia, Mohammed K. Alsharef, Mahdi Almutairi, Nouf Ababtain, Mohammed Alajmi, Abdulrahman Alrajhi, Faisal Alhusain, Mohammad Al Deeb
Clinical Characteristics And Outcomes Of Patients With Amphetamine Associated Emergency Department Visits At A Tertiary Care Hospital In Riyadh, Saudi Arabia, Mohammed K. Alsharef, Mahdi Almutairi, Nouf Ababtain, Mohammed Alajmi, Abdulrahman Alrajhi, Faisal Alhusain, Mohammad Al Deeb
Saudi Medical Journal
Objective: To investigate the demographic and clinical profiles of patients presenting with amphetamine-related emergencies at a tertiary hospital in Riyadh, Saudi Arabia. Amphetamine use is an escalating public health issue linked to a rise in emergency department (ED) visits. Methods: This retrospective study encompasses 14 years and focuses on individuals diagnosed with amphetamine-related toxicity. Results: Among the 659 cases studied, a predominant 96% were male, with over half (52%) aged between 19 and 30 years. Most patients (91%) were Saudi nationals. The leading cause of presentation was trauma, accounting for 24% of cases. This was followed by altered mental status …
Endovascular Thrombectomy For Acute Ischemic Stroke Among Stroke Patients In Jeddah, Saudi Arabia: A Retrospective Cohort Study (2024) Detailing Dual Center Experience, Abdullah M Alkutbi, Omar Abdulhamidayoub, Fawaz Mosaedalshareef, Mohammed M Alwadi, Rawan I Alqurashi, Rayan I Almaghrabi, Naif F Alharbi, Omar M Alhazmi, Ziad H Alzabidi, Nagham S Alsolaimani, Saher F Alqarni
Endovascular Thrombectomy For Acute Ischemic Stroke Among Stroke Patients In Jeddah, Saudi Arabia: A Retrospective Cohort Study (2024) Detailing Dual Center Experience, Abdullah M Alkutbi, Omar Abdulhamidayoub, Fawaz Mosaedalshareef, Mohammed M Alwadi, Rawan I Alqurashi, Rayan I Almaghrabi, Naif F Alharbi, Omar M Alhazmi, Ziad H Alzabidi, Nagham S Alsolaimani, Saher F Alqarni
Saudi Medical Journal
Background: Te evaluate the outcomes of Endovascular thrombectomy (EVT) -treated AIS patients in Jeddah, Saudi Arabia, and explores predictors of functional recovery. Endovascular thrombectomy (EVT) is the standard of care for acute ischemic stroke (AIS), though patient outcomes can vary based on regional and clinical factors. Method: A retrospective cohort study was conducted using medical records from King Abdulaziz University Hospital (KAUH) and King Fahad Hospital Jeddah (KFHJ), including AIS patients treated with EVT between January 2020 and July 2024. Neurological status was assessed using the NIH Stroke Scale (NIHSS), and clinical outcomes were evaluated with the modified Rankin Scale …
Gender Differences In Sociodemographic And Clinical Characteristics Of Methamphetamine Use In Saudi Arabia, Halima M. Adam, Mohamed Abouzed, Ahmed H. Aljadani, Benayan B. Alrasheedy, Muath A. Alarfaj, Salwa R. Alshammari, Mohamed S. Almuqahwi
Gender Differences In Sociodemographic And Clinical Characteristics Of Methamphetamine Use In Saudi Arabia, Halima M. Adam, Mohamed Abouzed, Ahmed H. Aljadani, Benayan B. Alrasheedy, Muath A. Alarfaj, Salwa R. Alshammari, Mohamed S. Almuqahwi
Saudi Medical Journal
Objectives: To explore gender-related variations in sociodemographic factors, clinical presentations, and psychosocial characteristics among methamphetamine users in Saudi Arabia. Methods: A retrospective cross-sectional study was conducted using the electronic health records of 1,181 patients (91% male, 9% female) treated at multiple Erada Mental and Addiction Centers across Saudi Arabia (2020–2024). Data on sociodemographic characteristics, methamphetamine use patterns, psychiatric comorbidities, and psychosocial functioning were collected and analyzed using validated tools, including the Addiction Severity Index, Beck Depression and Anxiety Inventory, and Quality of Life Scale. Results: Female participants were younger than males (mean age 25.3 vs 28.5 years; p < 0.001) and initiated methamphetamine at a later age (21.4 vs 19.2 years; p < 0.001). Females had greater proportion of daily use (65.4% vs. 60%, p = 0.035) but consumed smaller amounts per day (1.5 vs. 1.8 g, p = 0.041). They also exhibited higher rates of psychiatric comorbidities, including depression (50% vs. 30.0%, p < 0.001) and anxiety (40% vs. 20%, p < 0.001), and reported more severe psychosocial impairments, including lower quality of life (54.8 vs. 62.4, p < 0.001), higher unemployment rates (59.8% vs. 30%, p < 0.001), and more family conflicts (65.4% vs. 50%, p < 0.001). In contrast, Legal issues were more common among males (40% vs. 29.9%, p = 0.002). Conclusions: Female methamphetamine users demonstrate greater vulnerability with earlier onset, more psychiatric comorbidities, and worse psychosocial outcomes. Targeted interventions are needed for female methamphetamine users in Saudi Arabia.
Invasive Methicillin-Susceptible And Methicillin-Resistant Staphylococcus Aureus Infections In The Pediatric Population: Prevalence And Management Outcomes, Khalifa M. Binkhamis, Ibrahim A. Alhezam, Hassan A. Alabdullatif, Othman M. Alabdullah, Omar Y. Alkadhi, Nawaf M. Alrefaei, Abdullah S. Almayah, Fatema A. Juma, Sarah S. Alangari
Invasive Methicillin-Susceptible And Methicillin-Resistant Staphylococcus Aureus Infections In The Pediatric Population: Prevalence And Management Outcomes, Khalifa M. Binkhamis, Ibrahim A. Alhezam, Hassan A. Alabdullatif, Othman M. Alabdullah, Omar Y. Alkadhi, Nawaf M. Alrefaei, Abdullah S. Almayah, Fatema A. Juma, Sarah S. Alangari
Saudi Medical Journal
Objectives: Infections by invasive methicillin-resistant Staphylococcus aureus (MRSA) are associated with higher morbidity and mortality compared to methicillin-susceptible Staphylococcus aureus (MSSA) infections, and have increased significantly in both healthy children and children with chronic illnesses. In our study we aimed to estimate the prevalence of invasive MSSA and MRSA among invasive Staphylococcus aureus (S. aureus ) infections in the pediatric population and measure the association between management outcomes and methicillin resistance in these infections. Methods: We conducted an observational, analytical, retrospective cross-sectional, chart-review study of pediatric patients (aged ≤16 years) admitted to King Khalid University Hospital in Riyadh, Saudi Arabia …
Medication Errors Reporting And Analysis: A Comparative Study For Advancing Medication Safety Practices In Ministry Of Health Hospitals In Saudi Arabia, Saleh A. Alghamdi
Medication Errors Reporting And Analysis: A Comparative Study For Advancing Medication Safety Practices In Ministry Of Health Hospitals In Saudi Arabia, Saleh A. Alghamdi
Saudi Medical Journal
Objectives: To analyze and compare these stages, types, frequency, causes, and corrective actions related to medication errors (MEs) reported in Ministry of Health (MOH) hospitals in Saudi Arabia, and thereby enhance medication safety through data driven decisions. Methods: A retrospective cross-sectional study was conducted using ME reports submitted to the Saudi MOH national reporting system from January 2023 to December 2024.Data were collected from nine hospitals, covering medication involved, reporting personnel, level of harm and corrective actions. A novel stratification framework (NSF) was used to visualize emerging risks and protective trends. Statistical analyses were conducted using relative risk (RR), risk …
Sphingosine-1-Phosphate Regulation To Alleviate Sickle Cell Disease Severity: A Promising Therapeutic Approach, Shahanas Chathoth
Sphingosine-1-Phosphate Regulation To Alleviate Sickle Cell Disease Severity: A Promising Therapeutic Approach, Shahanas Chathoth
Saudi Medical Journal
Abstract Sickle cell disease (SCD) is a genetic disorder that affects millions of individuals worldwide. Chronic anemia, hemolysis and vasculopathy are the most common symptoms that arise from hemoglobin (Hb) polymerization, which is the primary event of SCD. The above process can lead to erythrocyte sickling. Therapeutic options for SCD remain limited, and novel therapies are still being evaluated for their effectiveness in particular populations. Sphingosine-1-phosphate (S1P), a significant bioactive sphingolipid, acts as a potent signal mediator, modulating several cellular functions. The potential role of erythrocyte-S1P in enhancing SCD severity has been previously reported by multiple studies. Therefore, the present …
From Text To Test: Pre-Lecture Reading Boosts Medical Students’ Comprehension And Retention, Hamad A. Alfahaad, Mohammed Y. Alasmary, Emad M. Masuadi, Henk G. Schmidt
From Text To Test: Pre-Lecture Reading Boosts Medical Students’ Comprehension And Retention, Hamad A. Alfahaad, Mohammed Y. Alasmary, Emad M. Masuadi, Henk G. Schmidt
Saudi Medical Journal
Objective: Medical students frequently attend lectures without prior review of the related literature when preparing for examinations. It raises the question of whether studying the material in advance could enhance their learning outcomes during lectures. Methods: A total of 102 medical students from a Saudi Arabian university took part in this research. Participants were assigned to one of 2 cohorts: one read a 4-page passage before a 15-minute lecture, while the other attended the lecture before reading the passage. Knowledge acquisition was measured using a test that assessed their ability to recall concepts administered 3 times—prior to the session, post …
National Heart Center/Saudi Heart Association 2025 Guidelines For Cardiovascular Diseases Prevention And Risk Assessment, Jamilah S Alrahimi, Laith Hussain-Alkhateeb, Ali M. Albarrati, Owayed M. Alshammeri, Talal S. Alghamdi, Ada M Al-Qunaibet, Nada A. Alnaji, Rasha A. Alfawaz, Waleed M. Alharbi, Waleed A. Alhabeeb, Fahad M. Alnouri, Adel A. Tash
National Heart Center/Saudi Heart Association 2025 Guidelines For Cardiovascular Diseases Prevention And Risk Assessment, Jamilah S Alrahimi, Laith Hussain-Alkhateeb, Ali M. Albarrati, Owayed M. Alshammeri, Talal S. Alghamdi, Ada M Al-Qunaibet, Nada A. Alnaji, Rasha A. Alfawaz, Waleed M. Alharbi, Waleed A. Alhabeeb, Fahad M. Alnouri, Adel A. Tash
Saudi Medical Journal
Objectives: To develop an evidence-based clinical guideline for the prevention and management of cardiovascular diseases (CVDs) in Saudi Arabia, tailored to local epidemiology and healthcare needs. Methods: A multidisciplinary task force comprising cardiologists, public health specialists, and epidemiologists from different healthcare sectors in Saudi Arabia developed the guideline. Evidence synthesis was based on a comprehensive literature review and adaptation of international guidelines, particularly the 2021 European Society of Cardiology recommendations, contextualized to the Saudi setting. Results: The guideline provides recommendations for both primary and secondary CVD prevention. Primary prevention emphasizes risk assessment incorporating genetic, lifestyle, and clinical factors, as well …
Obesity As A Health Priority: Insights From Research Productivity In The Arab World, Rania Hammami, Mirvat Alsnag
Obesity As A Health Priority: Insights From Research Productivity In The Arab World, Rania Hammami, Mirvat Alsnag
Saudi Medical Journal
No abstract provided.
Aba Renewal Of Fentanyl Seeking Using A Drug-Prime And Peer Stimulus In Rats, Meagan Blanchard
Aba Renewal Of Fentanyl Seeking Using A Drug-Prime And Peer Stimulus In Rats, Meagan Blanchard
University of Kentucky Master's Theses
People with opioid use disorder can experience craving and relapse to use when exposed to cues that were previously paired with the drug-taking environment. These cues can be both social and non-social in nature. This study aimed to explore the effect of a peer cue and a drug-prime cue, both together and separately. First, rats were trained to self-administer fentanyl in Context A (peer and drug present). Then, rats extinguished this behavior in Context B (no peer and no drug present) while self-administering saline instead of fentanyl. Lastly, rats underwent 4 different renewal test conditions (control, peer only, drug only, …
Engineering Plga Nanoparticle Size To Modulate Immune Responses After Spinal Cord Injury, Daniel J. Kolpek
Engineering Plga Nanoparticle Size To Modulate Immune Responses After Spinal Cord Injury, Daniel J. Kolpek
University of Kentucky Doctoral Dissertations
Spinal cord injury is a severe and debilitating condition that often results in lifelong complications, including paralysis. Many of these chronic outcomes are driven by a sustained inflammatory response at the injury site, which limits tissue regeneration and functional recovery. As a result, therapeutic strategies that modulate this immune response have gained significant interest. Polymer based nanoparticle therapies have emerged as a promising approach due to their ability to interact with and influence immune cell behavior. Importantly, the physicochemical properties of nanoparticles can be precisely tuned to optimize these effects. Among these properties, size has been shown to influence key …
Beyond Drugs And Surgery: Superselective Adrenal Artery Embolization Redefines Primary Aldosteronism Management-A Systematic Review And Meta-Analysis, Kimia Darmiani, Mehrad Zare, Alisa Mohebbi, Mohammad Mirza-Aghazadeh-Attari, Mohammad Ghasemi Rad, Afshin Mohammadi
Beyond Drugs And Surgery: Superselective Adrenal Artery Embolization Redefines Primary Aldosteronism Management-A Systematic Review And Meta-Analysis, Kimia Darmiani, Mehrad Zare, Alisa Mohebbi, Mohammad Mirza-Aghazadeh-Attari, Mohammad Ghasemi Rad, Afshin Mohammadi
Faculty, Staff and Students Publications
Background: Primary aldosteronism (PA) is a leading cause of secondary hypertension associated with increased cardiovascular and cerebrovascular risk. Superselective adrenal artery embolization (SAAE) has emerged as a minimally invasive alternative to adrenalectomy and mineralocorticoid receptor antagonists (MRAs). This systematic review and meta-analysis evaluates the efficacy and safety of SAAE in PA management.
Methods: We searched PubMed, Web of Science, Embase, and Cochrane Library through June 2026 for studies enrolling patients with PA treated by SAAE. Outcomes of interest were changes in blood pressure (BP), biochemical markers (serum potassium, aldosterone, renin activity, and aldosterone-to-renin ratio), clinical and biochemical response rates, daily …
The All Of Us Evenings With Genetics Research Program, Stacy M Lloyd, Jasmine Baker, Carolina Jorgez, Julie Coleman, Laterrica Williams, April Adams, Ashley Butler, Elizabeth Atkinson, Shamika Ketkar, Steven Scherer, Kim Worley, Susan Fernbach, Keasia Daniels, Latanya Hammonds-Odie, Laura Rosales, Brendan Lee, Debra Murray
The All Of Us Evenings With Genetics Research Program, Stacy M Lloyd, Jasmine Baker, Carolina Jorgez, Julie Coleman, Laterrica Williams, April Adams, Ashley Butler, Elizabeth Atkinson, Shamika Ketkar, Steven Scherer, Kim Worley, Susan Fernbach, Keasia Daniels, Latanya Hammonds-Odie, Laura Rosales, Brendan Lee, Debra Murray
Faculty, Staff and Students Publications
The All of Us Evenings with Genetics (All of Us EwG) Research Program, funded in part by the National Institute of Health’s All of Us Research Program, engages researchers to utilize the All of Us Researcher Workbench to advance precision medicine. The All of Us EwG program has two core aims: (1) address barriers to research productivity for minorities, disadvantaged, and persons with disabilities aspiring to enter STEM fields; and (2) promote the use of the All of Us Researcher Workbench to develop research focused on health equity. To achieve these goals, the program implements three key activities: (1) …
The Rna-Binding Protein Hur Modulates The Expression Of The Disease-Linked Ccl2 Rs1024611g-Rs13900t Haplotype, Feroz Akhtar, Joselin Hernandez-Ruiz, Ya-Guang Liu, Roy G. Resendez, Denis Feliers, Liza D. Morales, Alvaro Diaz-Badillo, Donna M. Lehman, Rector Arya, Juan Carlos Lopez-Alvarenga, John Blangero, Ravi Duggirala, Srinivas Mummidi
The Rna-Binding Protein Hur Modulates The Expression Of The Disease-Linked Ccl2 Rs1024611g-Rs13900t Haplotype, Feroz Akhtar, Joselin Hernandez-Ruiz, Ya-Guang Liu, Roy G. Resendez, Denis Feliers, Liza D. Morales, Alvaro Diaz-Badillo, Donna M. Lehman, Rector Arya, Juan Carlos Lopez-Alvarenga, John Blangero, Ravi Duggirala, Srinivas Mummidi
School of Medicine Publications
CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis. The rs1024611 (alleles: A>G; G is the risk allele) polymorphism in the CCL2 cis-regulatory region is associated with increased CCL2 expression in vitro and ex vivo, leukocyte mobilization in vivo, and deleterious disease outcomes. However, the molecular basis for the rs1024611-associated differential CCL2 expression remains poorly characterized. It is conceivable that genetic variant(s) in linkage disequilibrium (LD) with rs1024611 could mediate such effects. Previously, we used rs13900 (alleles: C>T) in the CCL2 …
Accountability For Lawyers And Lawyer-Bashers: Reflections On Wendel's Canceling Lawyers, David Luban
Accountability For Lawyers And Lawyer-Bashers: Reflections On Wendel's Canceling Lawyers, David Luban
Georgetown Law Faculty Publications and Other Works
This article is part of a symposium on W. Bradley Wendel’s Canceling Lawyers: Case Studies of Accountability, Toleration, and Regret. I agree with Wendel’s two fundamental claims: first, and contrary to the reigning conception, lawyers can be held accountable for choosing to represent a particular client (assuming they have a choice), and therefore that they cannot use their professional role as a “magic shield or force field” (Wendel’s term) to deflect all criticism. Second, however, there is also an ethics of blaming, and critics who blame lawyers irresponsibly can themselves be blamed. One of Wendel’s examples is lawyers who …
Creation And The Republican Revival, William M. Treanor
Creation And The Republican Revival, William M. Treanor
Georgetown Law Faculty Publications and Other Works
Gordon Wood's classic book Creation of the American Republic has long influenced legal thought and originalist scholarship in particular. It played a central role in the Republican Revival movement, an effort by leading scholars such as Cass Sunstein and Frank Michelman to recover a progressive originalism at the same time as conservative originalism was starting to shape constitutional jurisprudence. But, while the Republican Revival nominally relied on Wood, it misread central elements of his book - his concept of virtue and his belief that republicanism had largely been displaced at the time of the drafting of the Constitution.
The time …
Holding The Line On Academic Freedom In Law School Clinics, Ty Alper, Praveen Kosuri, Beth Lyon, Alicia E. Plerhoples, Laura Riley, Robin Walker Sterling
Holding The Line On Academic Freedom In Law School Clinics, Ty Alper, Praveen Kosuri, Beth Lyon, Alicia E. Plerhoples, Laura Riley, Robin Walker Sterling
Georgetown Law Faculty Publications and Other Works
Since the emergence of modern clinical legal education, law school clinics have periodically faced political interference in their selection of clients and cases, interference that threatens clinics’ essential dual missions of training practice-ready lawyers and providing legal services to marginalized clients who would otherwise lack representation. While such pressure is not new, contemporary threats differ in scale and institutional form. Today, funding, oversight, and enforcement mechanisms are weaponized in an attempt to discipline universities, heightening institutional anxiety and prompting some universities to contemplate preemptive constraints on clinic autonomy in the name of risk management and reputational protection. This shift to …
Trolling The Rule Of Law: Presidential Lawfare, The Stalingrad Defense, And The Lawyers, David Luban
Trolling The Rule Of Law: Presidential Lawfare, The Stalingrad Defense, And The Lawyers, David Luban
Georgetown Law Faculty Publications and Other Works
This paper, part of a symposium on presidential lawfare, examines the so-called “Stalingrad Defense”—a strategy of total procedural obstruction—within the broader phenomenon of rule-of-law backsliding facilitated by legal professionals. By exhausting judicial resources and weaponizing procedural delays on behalf of political leaders, such lawyers do not merely defend a client; they actively participate in subverting the institutional foundations of democracy. I argue that the standard conception of legal ethics, which emphasizes neutral partisanship and zealous advocacy, is fundamentally inadequate to capture the wrongfulness of lawyers who use legal tools to dismantle the legal system itself. In its place, I propose …
Rethinking Legal Models For Aligning U.S.-African Trade And The Afcfta, Katrin Kuhlmann
Rethinking Legal Models For Aligning U.S.-African Trade And The Afcfta, Katrin Kuhlmann
Georgetown Law Faculty Publications and Other Works
The U.S.-African trade relationship has become increasingly volatile and conditional, with significant implications for supply chains, trade corridors, and regional and global markets. This relationship has historically been based on a unilateral, preferential legal approach through a trade preference programme – the African Growth and Opportunity Act (AGOA) – under which individual countries petition for eligibility to receive duty-free treatment. AGOA expired in September 2025 in the midst of U.S. tariffs, but in early 2026 the programme was retroactively reauthorised through December 2026, with further application subject to “modernisation” and alignment with the “America First” policy. While many see reauthorisation …