Digital Commons Network^™

Excellent Outcomes In Feasibility Study Of Radiation-Free Conditioning And Transplant In Pediatric Severe Aplastic Anemia, Mithra Lakshmi Narasimhan, Irem Eldem, Jeffrey J Bednarski, Ginny L Schulz, Robert J Hayashi, Shalini Shenoy

2020-Current year OA Pubs

Severe aplastic anemia (SAA) is treated with a hematopoietic cell transplant (HCT) in the presence of an HLA-matched sibling donor (MSD) with disease-free survival (DFS) of >90%. In the absence of an MSD, immunosuppressive therapy (IST) can induce remission but concerns for relapsed/refractory disease and clonal hematopoiesis persist. IST failure is an indication for HCT. Modern HCT approaches target barriers such as graft rejection (GR), graft-versus-host disease (GVHD), and transplant-related toxicities. Traditionally, total body irradiation (TBI) inclusive HCT conditioning helps decrease GR, but the use of TBI in children increases concerns for late effects such as malignancies. To describe outcomes …

Perceived Hiv Risk, Barriers, And Preferences For Hiv Testing In Structurally Vulnerable Communities In St. Louis: A Best-Worst Scaling Survey, Emmanuel K Tetteh, Noelle Le Tourneau, Gregory Gross, Mckenzie Swan, Tyrell Manning, Justin Cole, Katie Wolf, Lawrence Hudson-Lewis, Julia D López, Todd Combs, Virginia R Mckay

2020-Current year OA Pubs

BackgroundPersistent gaps in efforts to end the HIV epidemic in the United States highlight the need for community-specific, evidence-based HIV testing strategies. This study investigated barriers and preferences around HIV testing among underserved populations, including Black, queer, and young adults in the St. Louis, Missouri area.MethodsWe conducted a Best-Worst Scaling (BWS) survey with adults (16+ years) recruited at community events, collecting responses electronically and providing a $25 incentive. The survey assessed the relative importance of 13 potential barriers to HIV testing such as stigma, structural barriers, and perceived HIV risk, chosen based on literature review and community input. Mean preference …

Comparison Of Breast And Gastric Her2 Immunohistochemistry (Ihc) Scoring Criteria In The Assessment Of Endometrial Carcinoma, Rachel L Furuya, Whitney Grither, Matthew A Powell, Premal H Thaker, Et Al.

2020-Current year OA Pubs

BACKGROUND: Immunohistochemistry (IHC) testing is the primary method to determine HER2 status at many institutions, often with reflex to in situ hybridization (ISH). DNA- and RNA- based platforms are emerging for HER-2 assessment. While approved IHC algorithms exist for HER2 scoring in breast and gastric carcinomas, neither has been validated in endometrial cancer. This study seeks to compare them and evaluate patterns of DNA and RNA expression.

METHODS: 263 endometrioid endometrial adenocarcinoma (EEA), 275 serous endometrial carcinoma (SEC), and 214 uterine carcinosarcoma (UCS) specimens were randomly selected. Previously stained HER2 IHC slides underwent blinded review by two board-certified pathologists and …

A Single-Cell Atlas Characterizes Dysregulation Of The Bone Marrow Immune Microenvironment Associated With Outcomes In Multiple Myeloma, William C Pilcher, Lijun Yao, Yizhe Song, Kazuhito Sato, Julia T Wang, Reyka G Jayasinghe, Jennifer A Foltz, Mark A Fiala, Chiang I-Ling, Julie Fortier, Michael Slade, Stephen T Oh, Michael P Rettig, John F Dipersio, Shaji Kumar, Ravi Vij, Li Ding, Et Al.

2020-Current year OA Pubs

Multiple myeloma (MM) remains incurable despite advances in treatment options. Although tumor subtypes and specific DNA abnormalities are linked to worse prognosis, the impact of immune dysfunction on disease emergence and/or treatment sensitivity remains unclear. We developed an Immune Atlas of MM by generating profiles of 1,397,272 single cells from the bone marrow (BM) of 337 newly diagnosed participants and characterized immune and hematopoietic cell populations. Cytogenetic risk-based analysis revealed heterogeneous associations with T cells of BM, with 17p13 deletion showing distinct enrichment of a type 1 interferon signature. The disease progression-based analysis revealed the presence of a proinflammatory immune …

Atomic Models Of The Toxoplasma Cell Invasion Machinery, Jianwei Zeng, Yong Fu, Pengge Qian, Wei Huang, Qingwei Niu, Wandy L Beatty, Alan Brown, L David Sibley, Rui Zhang

2020-Current year OA Pubs

Apicomplexan parasites, responsible for toxoplasmosis, cryptosporidiosis and malaria, invade host cells through a unique gliding motility mechanism powered by actomyosin motors and a dynamic organelle called the conoid. Here, using cryo-electron microscopy, we determined structures of four essential complexes of the Toxoplasma gondii conoid: the preconoidal P2 ring, tubulin-based conoid fibers, and the subpellicular and intraconoidal microtubules. Our analysis identified 40 distinct conoid proteins, several of which are essential for parasite lytic growth, as revealed through genetic disruption studies. Comparative analysis of the tubulin-containing complexes sheds light on their functional specialization by microtubule-associated proteins, while the structure of the preconoidal …

Influence Of Obesity And Insulin Resistance With Hepatic Steatosis On The Human Plasma Lipidome, Max C Petersen, Gordon I Smith, Aaron M Armando, Xiong Su, Oswald Quehenberger, Edward A Dennis, Samuel Klein

2020-Current year OA Pubs

Insulin resistance accompanied by hepatic steatosis is a common complication of obesity. In an effort to identify plasma lipids that could be biomarkers or causes of insulin resistance with steatosis in people with obesity, we evaluated the plasma lipidome in three distinct groups separated by adiposity, hepatic steatosis, and insulin sensitivity, assessed by using the hyperinsulinemic-euglycemic clamp procedure: i) insulin-sensitive lean (ISL, n = 13); ii) insulin-sensitive obese (ISO, n = 14); and iii) insulin-resistant obese with hepatic steatosis (IROS, n = 13). We evaluated 759 complex lipid species in 16 subclasses (including phospholipids, glycerolipids, sphingolipids, acylcarnitines, and cholesteryl esters) …

On-Device Artificial Intelligence Solutions With Applications To Smart Environments, Fabrizio De Vita, Dario Bruneo, Sajal K. Das

Computer Science Faculty Research & Creative Works

Recent advances in Artificial Intelligence (AI) and the increasing availability of computational power have accelerated the diffusion of Intelligent Cyber-Physical Systems (ICPSs), enabling smart applications with reasoning capabilities. However, the limited resources of embedded and Edge devices significantly constrain the complexity of deep learning models that can be effectively deployed. Traditional approaches rely on cloud-based training and edge-only inference, a paradigm that becomes inadequate when low latency, privacy, security, and high customization are required. In this context, On-device AI is emerging as a new paradigm in which both training and inference are performed directly on the device, avoiding data transfer …

Fairrfl: Fair And Robust Federated Learning In The Presence Of Selfish Clients, Andrea Augello, Ashish Gupta, Giuseppe Lo Re, Sajal K. Das

Computer Science Faculty Research & Creative Works

Federated Learning (FL) is a paradigm that enables collaborative machine learning without disclosing the local data of the participants. However, in real-world FL deployment scenarios, some unscrupolous clients may alter the training process to skew the global model towards their local optimum, unfairly prioritizing their data distribution. Their influence can degrade overall model performance for normal clients and reduce fairness in the system. We call this novel category of misbehaving clients 'selfish'. This work proposes a Fair and Robust strategy for aggregation in the Federated Learning (FL) server to mitigate the effect of Selfish clients (FairRFL). FairRFL incorporates a novel …

Smartflow: A Communication-Efficient Sdn Framework For Cross-Silo Federated Learning, Osama Abu Hamdan, Hao Che, Engin Arslan, Md Arifuzzaman

Computer Science Faculty Research & Creative Works

Cross-silo Federated Learning (FL) enables multiple institutions to collaboratively train machine learning models while preserving data privacy. In such settings, clients repeatedly exchange model weights with a central server, making the overall training time highly sensitive to network performance. However, conventional routing methods often fail to prevent congestion, leading to increased communication latency and prolonged training. Software-Defined Networking (SDN), which provides centralized and programmable control over network resources, offers a promising way to address this limitation. To this end, we propose SmartFLow, an SDN-based framework designed to enhance communication efficiency in cross-silo FL. SmartFLow dynamically adjusts routing paths in response …

Utility-Preserving Federated Graph Learning With Dual-Perspective Fairness, Renqiang Luo, Huafei Huang, Shuo Yu, Fengqi Yu, Feng Xia, Sajal K. Das, Chengqi Zhang

Computer Science Faculty Research & Creative Works

Fairness-aware federated graph neural networks (FedGNNs) necessitate consideration of both the server and the clients. However, fairness-aware methods struggle to enhance dual-perspective (i.e., server and clients) fairness without sacrificing utility due to the distributed learning framework. As a consequence, the utility sacrifices of fairness-aware graph learning methods are even exacerbated in federated frameworks. In this work we propose F3GL, a dual-perspective fairness federated graph learning method that enhances both global (for the server) and local fairness (for clients) while preserving utility. Through theoretical analysis, we delineate the similarity between original sensitive features and those after convolution under different spectra. Our …

Lost Before Forgetting: Objective Driving Metrics Track Navigation Deficits Tied To Preclinical Alzheimer's Disease, Yiqi Zhu, Ramkrishna K Singh, Semere Bekena, David C Brown, Chen Chen, Matthew Blake, Jean-François Trani, Ganesh M Babulal

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Navigation is a complex, multisensory process in which subtle changes may emerge before the onset of symptomatic Alzheimer's disease (AD). This study investigated whether navigation abilities were associated with amyloid and tau pathology in cognitively normal older adults.

RESEARCH DESIGN AND METHODS: Among 285 cognitively unimpaired older adults, navigation and objective driving behaviors were assessed using the self-reported Santa Barbara Sense of Direction Scale (SBSOD) and a datalogger, respectively. Amyloid and tau burden were quantified using PET-MRI 2 years post-initial driving data collection. Linear mixed-effects models were used to evaluate the associations between biomarker status and longitudinal …

Advancing Inter-Brain Synchrony Measurement: A Comparative Hyperscanning Study Of Diffuse Optical Tomography And Functional Near-Infrared Spectroscopy, Shuo Guan, Yuhang Li, Yingbo Geng, Dongyun Li, Qiong Xu, Peisong Niu, Dalin Yang, Adam Eggebrecht, Yingchun Zhang, Rihui Li

2020-Current year OA Pubs

Inter-brain synchrony (IBS), measured by hyperscanning, refers to the synchronization of multiple individuals' brain activities during social interactions. Traditional fNIRS-based hyperscanning suffers shortcomings like low spatial resolution and high susceptibility to superficial interference, causing imprecise estimation of IBS in complex social tasks. This study aims to fill the knowledge gap by comprehensively assessing diffuse optical tomography (DOT), an enhanced alternative to fNIRS, can benefit hyperscanning studies of complex social interactions. Sixteen dyads were engaged in both collaborative and individual tangram puzzle tasks, and their brain activities were recorded simultaneously using DOT and fNIRS. We found that DOT demonstrated significantly stronger …

Abnormalities In Sensorimotor Brain Function Are Related To Chronicity Of Low Back Pain, Jo Armour Smith, Rongwen Tain, Kelli G Sharp, Laura M Glynn, Linda R Van Dillen, Jesse V Jacobs, Steven C Cramer

2020-Current year OA Pubs

Maladaptive plasticity in the brain may contribute to chronic low back pain (LBP) and underlie the altered postural control of the lumbopelvic musculature that is evident in some individuals with LBP. We recently described an MRI-compatible leg-raise paradigm to measure brain activity associated with lumbopelvic postural control. The objective of this study was to compare brain function in young adults with and without a history of LBP and to determine relationships between brain function, pain, and postural control characteristics. We recruited 55 participants with a history of LBP, who were asymptomatic when studied, and 30 healthy controls. Postural control during …

Clinical Outcomes Following Mechanical Thrombectomy In Pulmonary Embolism Response Team-Consulted Patients: A Retrospective Analysis, Ryan Nolan, Maanasi Samant, Suresh Vedantham, Westley Ohman, Nathan Droz, Kristen Sanfilippo, Pavan Kavali

2020-Current year OA Pubs

PURPOSE: To determine if use of mechanical thrombectomy (MT) impacts survival and additional outcomes in patients with acute intermediate-high-risk and high-risk pulmonary embolism (PE) who were evaluated by a Pulmonary Embolism Response Team (PERT).

METHODS: This retrospective, single-center study included patients with intermediate-high-risk and high-risk PE who received PERT evaluation over 3.5 years and were treated with anticoagulation (AC) alone or MT + AC. The primary outcome was 30-day all-cause mortality, measured with inverse probability of treatment weighting. Exploratory outcomes included survival during the study period, PE-associated/caused mortality, hospital length of stay (LOS), supplemental oxygen at discharge, and MT-related metrics. …

Knowledge, Interest, And Willingness Of Hematologists And Oncologists To Care For Adults With Vascular Anomalies, Bryan A Sisk, Anna M Kerr, Sally Cohen-Cutler, Margaret T Lee, Katie Harmoney, Alexandra Borst, Shelley E Crary, Shelbie Fishman, Stephanie Chen, Danielle Cicka, Stephanie Milam, Christine Bereitschaft, Kristen M Sanfilippo

2020-Current year OA Pubs

BACKGROUND: Vascular anomalies (VAs) are rare diseases that cause significant morbidity. Adults with VAs struggle to access expert care. Hematologists and oncologists in adult medicine are positioned to provide expert care, but no prior studies have characterized their openness to this role.

OBJECTIVES: This study characterized the experience, confidence, willingness, and motivating factors for hematologists/oncologists to care for adults with VAs.

METHODS: We surveyed United States hematologists and oncologists in adult medicine between October 2024 and March 2025. The questionnaire assessed knowledge, experience, confidence, and willingness to care for adults with VAs, as well as open-ended questions assessing factors influencing …

Mouse Alport Podocytes Are Susceptible To Aav9 Transduction In Vivo, Meei-Hua Lin, Kohei Omachi, Joshua F Begin, Jennifer L Richardson, Jeffrey H Miner

2020-Current year OA Pubs

INTRODUCTION: Alport syndrome features a defective glomerular basement membrane (GBM) due to variants in COL4A3, COL4A4, and COL4A5. The most severe forms, which lack the GBM's collagen α3α4α5(IV) network, progress from hematuria in early childhood to proteinuria, chronic kidney disease, and kidney failure by the age of ∼30. As a monogenic disease without specific treatments, and with podocytes being the only glomerular cells that synthesize collagen α3α4α5(IV), the ability to efficiently deliver genes to Alport podocytes could open up new possibilities for treatment.

METHODS: As a proof-of-concept study, we investigated whether podocytes in X-linked Alport mice were susceptible to transduction …

Cgrp Expression And Signaling Sensitization In A Mouse Model Of Chronic Oxaliplatin-Induced Peripheral Neuropathy, Junwei Du, Leland C Sudlow, Margaret H Johnson, Kanishk Satish, Abraham Villagomez, Hongzhen Hu, Mikhail Y Berezin

2020-Current year OA Pubs

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and dose-limiting side effect of oxaliplatin treatment, yet its molecular mechanisms remain incompletely understood. Calcitonin gene-related peptide alpha (CGRPα, encoded by

The Effectiveness Of A Program Based On The Use Of Concept Maps In Improving Descriptive Text Among Female Students With Learning Disabilities, Bedour Ahmed Bahamam

University of Tabuk Journal for Humanities and Social Sciences

This study aimed to investigate the effectiveness of a program based on the use of concept maps in improving descriptive text writing among middle school female students with learning disabilities. The study employed a quasi-experimental methodology using a single-group pre-test and post-test design. The research instruments included a training program and descriptive writing tasks. The study sample consisted of 21 middle school female students with learning disabilities in Riyadh. The results revealed statistically significant differences between the pre-test and post-test in the number of words produced in the descriptive texts, with the post-test showing superior performance. Additionally, statistically significant differences …

Consumer Rights In E-Commerce Contracts Under The Saudi Legal System: Reality And Challenges, Saeed Abdullah Badawi Al-Zahrani

University of Tabuk Journal for Humanities and Social Sciences

E-commerce is rapidly evolving in the Kingdom of Saudi Arabia, which necessitates the intervention of the Saudi legislator to provide greater protection for consumers who face various challenges in e-commerce contracts. The central research problem lies in identifying the challenges facing consumer rights in e-commerce contracts under the Saudi legal system and exploring ways to enhance consumer protection in this field - a question this study seeks to answer. This study aims to clarify the concept of e-commerce and the notion of consumer rights in e-commerce, while also highlighting the most significant challenges consumers face in such contracts. Moreover, it …

Digital Aesthetics And Post-Internet Art: Transformations Of The Saudi Art Scene Between Global Discourse And Local Narrative, Lina M. Kattan

University of Tabuk Journal for Humanities and Social Sciences

This research investigates the evolution of artistic practices in Saudi Arabia, focusing on the impact of digital infrastructures and "post-Internet" aesthetics. Addressing the challenges within the Kingdom's 2030 Vision for cultural transformation, the study examines how digital technologies are reshaping art production and exhibition. The core problem lies in understanding Saudi artists' engagement with the global digital landscape while preserving their connection to Arab and Islamic cultural traditions. The research clarifies the dynamic interplay between global digital art discourse and local storytelling, exploring how artists utilize new technologies and addressing challenges like digital archiving, virtual exhibition sustainability, and technological access …

Presupposition In Shaqraa Al-Madkhali's "I Almost See Me": A Pragmatic Study, Hadiah Faiz Monawer Alrashidy

University of Tabuk Journal for Humanities and Social Sciences

This research investigates the presuppositions inherent in the poetic collection (Diwan) titled "Akadu Arani" (I Almost See Myself) by the poetess, Shaqra al-Madkhali. The study aims to categorize these presuppositions and analyze their functional role in articulating the poetess's intentionality, ultimately facilitating the efficacy of the communicative process. Methodologically, the paper adopts a pragmatic framework complemented by a descriptive-analytical approach. The study is organized into an introduction, a theoretical preamble on the concept of presupposition, and five core analytical sections: (1) Existential, (2) Factive, (3) Lexical, (4) Structural, and (5) Non-factive presupposition. The investigation concludes with several key findings, most …

The Extent Of Acquiring Scientific Concepts In Science Curricula In The Primary Stage For Hearing, Deaf, And Hard-Of-Hearing Students: Evaluating Achievement, Teaching Practices, Challenges, And Improvement Mechanisms, Rashdan Bin Humeed Bin Masoud Al-Mutarrfi

University of Tabuk Journal for Humanities and Social Sciences

This study aimed to investigate the level of acquisition of scientific concepts among hearing, deaf, and hard-of-hearing students in the fifth and sixth grades, and to identify the teaching practices used by science teachers when teaching scientific concepts to these students. Additionally, the study sought to uncover the challenges faced by science teachers in teaching scientific concepts to hearing, deaf, and hard-of-hearing students and to propose mechanisms to help science teachers in primary education increase the acquisition of scientific concepts among these students. The study sample consisted of 136 male and female students and 137 male and female teachers. The …

Evaluating The Quality Of Learning Disabilities Programs In Saudi Arabia From Teachers' Perspectives: Qualitative Study, Ahmed Lowiheg Aldousari

University of Tabuk Journal for Humanities and Social Sciences

This study investigates the quality of learning disabilities (LD) programs in the Kingdom of Saudi Arabia (KSA) from the perspectives of teachers directly involved in their implementation. The study adopts a qualitative research design, utilizing semi-structured interviews conducted with ten teachers of learning disabilities, including five male and five female teachers. The aim of the study is to explore teachers' perceptions of the effectiveness of current LD programs, identify key challenges encountered in practice, and highlight areas for improvement. The findings reveal that while teachers demonstrate strong commitment and positive attitudes toward supporting students with learning disabilities, several challenges persist, …

Assessing Teachers' Perceptions Toward Giftedness And Creativity Among Students With Learning Disabilities In Regular Classrooms In The Ha'il Region, Muqrin Mubrik Almutairi

University of Tabuk Journal for Humanities and Social Sciences

In this study, the researcher sought to assess teachers' perceptions toward giftedness and creativity among students with learning disabilities in regular classrooms in the Ha'il region. The sample consisted of 155 teachers working in public schools during the 2024-2025 academic year. A demographic survey was used to collect categorical information on participants. Categories included gender, academic qualification, teaching experience, and training courses. The study adopted a descriptive survey design and employed a questionnaire developed to explore teachers' perceptions across three domains: perceptions of giftedness and creativity in all students, perceptions of learning disabilities, and perceptions of giftedness and creativity among …

Designing An Instructional Unit To Develop Skills In Sustainable Children's Clothing Production, Mona Omar Ali Al Omar

University of Tabuk Journal for Humanities and Social Sciences

The manufacture of sustainable children's garments-particularly reverse-style transformative clothing-has recently emerged as an innovative approach aimed at maximising utilisation efficiency by designing multifunctional products that prolong service life and reduce waste. The significance of this study lies in preparing female students to engage with the rapid advancements in sustainable apparel production, thereby strengthening their capacity to meet the demands of a modern labour market that increasingly values innovation and sustainability. The study sought to design an instructional unit that would enhance students' knowledge and skills in producing sustainable, reverse-transformative children's clothing, and to implement the unit in order to assess …

A Stylistic Analysis Of Abu Tammam's Poem "Aya Wayla Al-Shaji Min Al-Khali", Fatimah Abdullah Al Shammry

University of Tabuk Journal for Humanities and Social Sciences

This research undertakes a stylistic study of Abu Tammam's poem "Aya Wayl al-Shajiyy min al-Khaliyy," seeking to reveal the aesthetic and semantic characteristics that distinguish the stylistic structure of his poetry. The study adopted the stylistic approach as a theoretical and analytical framework for examining the poetic text through its phonetic, syntactic, semantic, and rhetorical levels, based on a perspective that views language as a tool for generating both meaning and emotion. The research consists of two main sections: the first addresses the theoretical framework, including the definition of stylistics, its origins, methods, and trends, alongside a biographical overview of …

The Judgments Of The Commentators On Ibn Malik's Statements Concerning Apparent Discrepancies Between Al-Tashil And Its Commentary: A Critical Study, Sarah Abdullah Abdul Aziz Al-Sabih

University of Tabuk Journal for Humanities and Social Sciences

This study examines the instances in which commentators on al-Tashil pointed to what appears to be a difference between Ibn Malik's statements in Tashil al-Fawa'id wa-Takmil al-Maqasid and his Sharh al-Tashil. It aims to analyze these judgments and assess their validity considering textual context and grammatical methodology. Adopting a descriptive-analytical approach, the study correlates the concise formulations of the Tashil with their expanded explanations in the commentary and traces the criteria employed by the commentators in identifying difference or inconsistency. The findings indicate that most cases described as contradiction do not constitute genuine inconsistency. Rather, they result from variation in …

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a wide-spectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (−72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

More Than Just Multiculturally Competent: Doctoral Student Competency And Preparedness To Work With Individuals With Disabilities, Kristen N. Dickens, Chantrelle Varnado-Johnson, Synthia Best

Georgia Educational Researcher

Phenomenological inquiry was used to interview counselor education doctoral students about their experiences and perceived competency and preparedness to counsel individuals with disabilities. Three overarching themes emerged: (1) continuous self-directed learning, (2) disability is multifaceted, misunderstood, and evolving, and (3) influential learning factors. Implications and recommendations for counselor educators and training programs are provided.

Using Culturally Familiar Readings In A Predominantly Latinx Middle School To Bolster Self-Efficacy, Heather M. Kelley Ph.D., Morgan Adams, Meagan Chisholm, Kate Warner

Georgia Educational Researcher

Twenty-eight seventh graders from a predominantly Latinx middle school participated in an instructional intervention involving both a culturally familiar and unfamiliar reading task. Immediately after reading, students joined focus groups to discuss their experiences. These sessions were recorded, transcribed, and analyzed using a discourse analysis framework. The analysis revealed that students based their reading self-efficacy on three key factors: their ability to relate to the text, their interest in the story, and the perceived difficulty of the task. The findings suggest that implementing culturally sustaining pedagogy—through the use of culturally relevant texts—can enhance reading self-efficacy and support academic achievement for …