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Articles 107161 - 107190 of 107906
Full-Text Articles in Entire DC Network
The Influence Of Scale In Modeling Social Vulnerability And Disaster Assistance, Sina Razzaghi Asl, Oronde Drakes, Eric Tate, Samuel Brody, Wesley Highfield, Kayode Atoba
The Influence Of Scale In Modeling Social Vulnerability And Disaster Assistance, Sina Razzaghi Asl, Oronde Drakes, Eric Tate, Samuel Brody, Wesley Highfield, Kayode Atoba
Political Science & Geography Faculty Publications
Understanding how social vulnerability relates to disaster impacts is critical for addressing social equity, yet the role of spatial scale in this relationship is often overlooked. Most studies use aggregated data, risking ecological fallacy-misinterpreting individual outcomes from group-level data. This study examines how spatial scale influences the relationship between social vulnerability and federal disaster assistance after Hurricane Harvey. Using spatial econometric models at both household and census tract levels, we assessed the strength of key vulnerability indicators in explaining disaster assistance. Results show that disability, housing tenure, household size, and income predict assistance at the household level, but their influence …
Africa As A Strategic Arena: How Great Power Rivalry Is Reshaping Security Governance, Chick Edmond
Africa As A Strategic Arena: How Great Power Rivalry Is Reshaping Security Governance, Chick Edmond
Political Science & Geography Faculty Publications
The rising importance of Africa as a key battleground in great power rivalry is an important shift in global politics that will have significant impacts on security governance in Africa. This article will explore the ways in which increased competition between the U.S., China and Russia will affect African states and regional organizations, and how economic dependency, regional security architecture and diplomatic strategy will influence the overall security environment in Africa. Using recent case studies and academic research, along with current policy analysis, it will analyze whether or not African countries and regional organizations will be able to mitigate potential …
Beyond Discrete Indicators: Modeling Intersectional Flood Vulnerability, Sina Razzaghi Asl, Eric Tate, Christopher T. Emrich, Md Asif Rahman, Kaeleb Royster
Beyond Discrete Indicators: Modeling Intersectional Flood Vulnerability, Sina Razzaghi Asl, Eric Tate, Christopher T. Emrich, Md Asif Rahman, Kaeleb Royster
Political Science & Geography Faculty Publications
Social vulnerability to flooding is shaped by intersectional social marginalization, yet most quantitative assessments employ indicators of single populations. This study applies spatial machine learning to examine how the intersectional social vulnerability indicators of poverty-race, poverty-housing tenure, and race-housing tenure compare with traditional discrete indicators of single populations in predicting flood exposure in California. Using geographically weighted random forests and partial dependence plots, we model spatial heterogeneity and non-linear relationships between social vulnerability and exposure. We quantified flood exposure using a population-adjusted measure derived from building footprints and modeled 500-year fluvial and pluvial flood hazard. The results reveal distinct explanatory …
The Balance Of Power In Ukraine And Deterrence Effectivenes Against Nuclear-Armed Russia, Chick Edmond
The Balance Of Power In Ukraine And Deterrence Effectivenes Against Nuclear-Armed Russia, Chick Edmond
Political Science & Geography Faculty Publications
Russia's invasion of Ukraine has raised several significant questions regarding the impact of deterrence, the European balance of power and the ability of current security frameworks to restrict the actions of nuclear-armed revisionist powers. This paper uses an integrated theoretical framework consisting of deterrence theory, the balance of power theory, the security dilemma and neorealism to analyze the dynamic relationships between Russia, Ukraine and the Western alliance. The primary contribution of the paper is to develop a comprehensive analytical framework to evaluate the relationship between different aspects of deterrence (i.e., to prevent an initial attack, to limit further escalation and …
2026 Retirees Association Newsletter., Morehead State University. Alumni Association.
2026 Retirees Association Newsletter., Morehead State University. Alumni Association.
Morehead State Alumni Association Publications
The Morehead State University 2026 Retirees Association Newsletter.
Reduced Threat-Related Neural Efficiency: A Possible Biomarker For Pediatric Anxiety Disorders, Julia O. Linke, Reut Naim, Simona P. Haller, Parmis Khosravi, Beck Scheinberg, Meghan E. Byrne, Anita Harrewijn, Ellen Leibenluft, Melissa A. Brotman, Anderson M. Winkler, Daniel Samuel Pine
Reduced Threat-Related Neural Efficiency: A Possible Biomarker For Pediatric Anxiety Disorders, Julia O. Linke, Reut Naim, Simona P. Haller, Parmis Khosravi, Beck Scheinberg, Meghan E. Byrne, Anita Harrewijn, Ellen Leibenluft, Melissa A. Brotman, Anderson M. Winkler, Daniel Samuel Pine
School of Medicine Publications
Objective: Pediatric anxiety disorders are common and predict adult psychopathology, yet current treatments, such as cognitive-behavioral therapy (CBT), produce lasting remission in less than 50% of affected youths. To support the search for improved, mechanistically grounded interventions, this study evaluated neural efficiency, defined as similarity in functional connectivity between a threat task and rest, as a potential biomarker. The study evaluated neural efficiency in relation to anxiety diagnosis and treatment response.
Methods: The authors compared 103 youths with an anxiety disorder diagnosis (mean age, 12.5 years [SD=2.91], 62% female) to 103 youths with no psychiatric diagnosis (mean age, 13.4 years …
Toward Neurosymbolic Reinforcement Learning Via Editable Specifications, Vedant Khandelwal, Hong Yung Yip, Amit Sheth
Toward Neurosymbolic Reinforcement Learning Via Editable Specifications, Vedant Khandelwal, Hong Yung Yip, Amit Sheth
Publications
Reinforcement learning systems are commonly adapted to new settings by retraining or fine-tuning policies. This default is costly, difficult to audit, and poorly aligned with structured requirement changes such as revised safety rules, new operational constraints, or updated user preferences. We argue for an alternative abstraction: adaptation via edits to an external, human-readable specification that the agent consults at execution time. We propose conditioning decision-making on an editable knowledge graph encoding (i) rules capturing action applicability and high-level effects, (ii) hard constraints defining feasibility, and (iii) soft preferences shaping tradeoffs among feasible behaviors. Requirement changes become graph edits, not policy …
Organic Pollutants And Risk Of Type 2 Diabetes: A Systematic Review And Meta-Analysis, Yousif M. Hydoub, Ricardo Loor-Torres, Abdul Qadeer, Kinaan Farhan, Thaer K. Swaid, Hanieh S.T. Yeganeh, Joelle N. Friesen, Shangwe Kiliaki, Iman Fawad, Danielle J. Gerberi, Thirumurugan Prakasam, Rainer Lohmann, H. Hassan Murad, Sagar B. Dugani
Organic Pollutants And Risk Of Type 2 Diabetes: A Systematic Review And Meta-Analysis, Yousif M. Hydoub, Ricardo Loor-Torres, Abdul Qadeer, Kinaan Farhan, Thaer K. Swaid, Hanieh S.T. Yeganeh, Joelle N. Friesen, Shangwe Kiliaki, Iman Fawad, Danielle J. Gerberi, Thirumurugan Prakasam, Rainer Lohmann, H. Hassan Murad, Sagar B. Dugani
Graduate School of Oceanography Faculty Publications
Objective: To evaluate the associations between organic pollutants (OPs) and risk of type 2 diabetes (T2D).
Patients and Methods: We searched Medline, Embase, Scopus, Web of Science, and Cochrane Central from inception through March 18, 2024. We included studies reporting the adjusted or unadjusted association between serum concentration of OPs and risk of T2D. We excluded studies on type 1 diabetes, self-reported exposure, and if fewer than 100 T2D cases. We classified OPs using 2 classification methods and reported pooled risk estimates using a random-effects model (odds ratio [95% CI]) and assessed risk of bias at the levels …
Allowing Unlimited Pfas Manufacturing Contradicts The Core Intention Of The European Union’S Pfas Restriction Proposal, Anna J. Miller, Amanda Rensmo, Ian Cousins, Rainer Lohmann, Gretta Goldenman, Dorte Herzke, Xenia Trier, Zhanyun Wang, Martin Scheringer
Allowing Unlimited Pfas Manufacturing Contradicts The Core Intention Of The European Union’S Pfas Restriction Proposal, Anna J. Miller, Amanda Rensmo, Ian Cousins, Rainer Lohmann, Gretta Goldenman, Dorte Herzke, Xenia Trier, Zhanyun Wang, Martin Scheringer
Graduate School of Oceanography Faculty Publications
No abstract provided.
Presence Of Legacy And Emerging Pfas In Human Liver Specimens Banked In The United States From 2000 To 2024, Juliana Agudelo Areiza, Jitka Becanova, Simon Vojta, Johanna Ganglbauer, Udayan Apte, Luigi Brunetti, Sean Kumer, Faiz Haque, Euna Kim, Elsie M. Sunderland, Rainer Lohmann, Fabian C. Fischer, Angela L. Slitt
Presence Of Legacy And Emerging Pfas In Human Liver Specimens Banked In The United States From 2000 To 2024, Juliana Agudelo Areiza, Jitka Becanova, Simon Vojta, Johanna Ganglbauer, Udayan Apte, Luigi Brunetti, Sean Kumer, Faiz Haque, Euna Kim, Elsie M. Sunderland, Rainer Lohmann, Fabian C. Fischer, Angela L. Slitt
Graduate School of Oceanography Faculty Publications
Per- and polyfluoroalkyl substances (PFAS) are persistent, bioaccumulative chemicals linked to liver toxicity and metabolic disease. 54 PFAS were measured in 211 adult human livers collected between 2000 and 2024 to reveal temporal trends, relative PFAS abundance, and demographic predictors of hepatic burden. PFAS were detected in 210 individuals, with 15 compounds found in ≥30 livers. Total summed PFAS concentrations decreased by 94% over the 24-year period in weighted linear regression, and by 68% after adjusting for age, sex, and liver health in multivariate models. Since 2019, a ∼950-fold variability in concentration was observed, and the PFAS profile in the …
Preliminary Cruise Report: Tn452 Eastern Lau Spreading Center And Northeastern Lau Basin, Kingdom Of Tonga, April 19, 2026 – May 18, 2026, Roxanne A. Beinart, Shawn Arellano
Preliminary Cruise Report: Tn452 Eastern Lau Spreading Center And Northeastern Lau Basin, Kingdom Of Tonga, April 19, 2026 – May 18, 2026, Roxanne A. Beinart, Shawn Arellano
Graduate School of Oceanography Faculty Publications
No abstract provided.
Relationship Among Sleep Disturbance, Stress, And Suicidal Ideation In Clinical High Risk For Psychosis, Heather M Wastler, Daniel Mamah, Et Al.
Relationship Among Sleep Disturbance, Stress, And Suicidal Ideation In Clinical High Risk For Psychosis, Heather M Wastler, Daniel Mamah, Et Al.
2020-Current year OA Pubs
BACKGROUND AND HYPOTHESIS: Sleep disturbance is a well-established risk factor for suicide, though few studies to date have examined whether sleep disturbance contributes to suicide risk among individuals at clinical high risk for psychosis (CHR). The current study addressed this gap in the literature. We hypothesized that sleep disturbance would have a unique relationship with suicidal ideation/attempts when accounting for other variables in the model. We also hypothesized that the interaction between sleep disturbance/attenuated positive symptoms and sleep disturbance/stress would be related to suicidal ideation/attempts in CHR.
STUDY DESIGN: The current study used data generated by the Accelerating Medicines Partnership® …
State Of The University Annual Report - 2025-2026, Office Of The President, East Tennessee State University, University Marketing And Communication, East Tennessee State University
State Of The University Annual Report - 2025-2026, Office Of The President, East Tennessee State University, University Marketing And Communication, East Tennessee State University
Office of the President State of the University Annual Report
No abstract provided.
Growing South Dakota (Winter 2026), College Of Agriculture, Food And Environmental Sciences
Growing South Dakota (Winter 2026), College Of Agriculture, Food And Environmental Sciences
Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)
[Page] 2 International Year of Rangelands and Pastoralists: South Dakota rangelands take center stage
[Page] 4 The professor and the soil
[Page] 8 Range ready: Helping students bridge the gap between conservation and agriculture
[Page] 9 Resilient rangelands: Native Plant Initiative’s role in reviving South Dakota’s prairies
[Page] 10 Jackrabbits lead the charge in bison research and education
[Page] 12 Agricultural and biosystems engineering celebrates century of education
[Page] 16 SDSU Quarter Scale Tractor Club: An impact beyond awards
[Page] 18 Building a legacy of opportunity: Karen D. Stuck Endowment strengthens agricultural communication program at South Dakota State University
[Page] …
Governing The Digital Commons, Madelyn Rose Sanfilippo, Brett Frischmann, Michael J. Madison, Katherine J. Strandburg
Governing The Digital Commons, Madelyn Rose Sanfilippo, Brett Frischmann, Michael J. Madison, Katherine J. Strandburg
Faculty Publications
The digital commons, as the coproduction of data, digital cultural products, and community, raise a variety of governance issues. From questions of participation, including voice mechanisms, to the legitimacy of decision-making or ownership, to specific action arenas, governance is complex and dynamic, reflecting the characteristics of the networks in which these commons are situated. This mini-track explores governance challenges and solutions across an array of case studies to highlight governance failures and solutions, many of which focus on reconciling the intersections of different action arenas and aligning policies with contextual norms.
The Paradox Of Matriliny: Cultural Authority And The Political Marginalization Of Women In Meghalaya, Kasturi Bharadwaj
The Paradox Of Matriliny: Cultural Authority And The Political Marginalization Of Women In Meghalaya, Kasturi Bharadwaj
Journal of International Women's Studies
The global discourse on gender equality gained momentum after the 1975 United Nations World Conference on Women. It continued through a series of international initiatives and culminated in the Beijing Declaration and Platform for Action, which emphasized women’s rights and their participation in political, social, and economic life. Despite these normative commitments at the international level, women’s political participation and representation within administrative and decision-making structures continue to be uneven, limited, and structurally constrained across many societies. In this context, the study investigates the political participation and representation of women in Meghalaya, a tribal state in Northeast India characterized by …
Comparing Us Medicare Coverage Options As A Contributing Mechanism To Sticking Or Switching To An Insurance Plan, Lisa M. Grabert, Brian J. Miller, Kathryn L. Wagner
Comparing Us Medicare Coverage Options As A Contributing Mechanism To Sticking Or Switching To An Insurance Plan, Lisa M. Grabert, Brian J. Miller, Kathryn L. Wagner
College of Nursing Faculty Research and Publications
Background
In 2025, the US Medicare program is expected to spend over $1.1 trillion taxpayer dollars. A growing trend in the US Medicare program is more beneficiaries electing a private insurer, referred to as Medicare Advantage (MA), to manage their care. Since 2023, a slight majority of Medicare beneficiaries have elected to enroll in MA, yet little is understood about the mechanisms that drive beneficiaries toward their choices.
Methods
Our objective was to examine the association between comparing coverage options and ‘switching’ or ‘sticking’ with Fee-for-Service (FFS) Medicare or Medicare Advantage (MA). We conducted a panel study, using data from …
Identifying Disparities In Same-Day Surgery Cancellations: Impact Of Race And Socioeconomic Factors In A Pediatric Health System, Nicole M Santucci, Daniel Alligood, Amanda Maytin-Hevia, Danyi Wang, Kelly Chilson, Jesse Vrecenak, Andrew Yeh, Colin A Martin
Identifying Disparities In Same-Day Surgery Cancellations: Impact Of Race And Socioeconomic Factors In A Pediatric Health System, Nicole M Santucci, Daniel Alligood, Amanda Maytin-Hevia, Danyi Wang, Kelly Chilson, Jesse Vrecenak, Andrew Yeh, Colin A Martin
2020-Current year OA Pubs
PURPOSE: Same-day surgery (SDS) cancellations have significant implications on patients and hospitals. This study aimed to identify demographic and socioeconomic factors that impact SDS cancellations across a single pediatric health system.
METHODS: A case-control retrospective review captured patients (age < 18) who underwent SDS procedures from July 2022 to August 2024. Patients were included if they underwent any procedure at three operative sites: a tertiary pediatric academic hospital (PAH) and two outpatient surgery centers (OSC). Patients whose SDS was cancelled (n = 2,034) were compared to those whose surgeries proceeded as scheduled (n = 25,573). Patient zip codes were matched to Child Opportunity Index (COI) 2.0 data.
RESULTS: The overall SDS cancellation rate was 7.37 %, with a significantly higher rate observed at the PAH compared to OSC (11.4 % vs 53 %, p < 0.001). Patients with cancelled cases were more likely to identify as Black and have the lowest quintile COI (p < 0.001). Cancelled in preop and no shows were two reasons with the most racial disparities. In a sub-analysis comparing cancelled cases between operating sites, PAH cancelled patients tended to be Black (23.8 % vs 11.7 %, p < 0.001) and have very low COI (20.1 % vs. 10.6 %, p < 0.001).
CONCLUSION: SDS cancellation rates are significantly higher amongst patients who identify as Black and reside in low opportunity neighborhoods. Disparities in cancellation rate are more significant in patients scheduled at the urban PAH compared …
Molar-Incisor Hypomineralization: Diagnosis, Management, And Treatment, Giovana Anovazzi Medeiros Dds, Msc, Phd, Bahareh Enghiad Dmd, James R. Boynton Dds, Ms
Molar-Incisor Hypomineralization: Diagnosis, Management, And Treatment, Giovana Anovazzi Medeiros Dds, Msc, Phd, Bahareh Enghiad Dmd, James R. Boynton Dds, Ms
The Journal of the Michigan Dental Association
Molar Incisor Hypomineralization (MIH) is a qualitative developmental enamel defect affecting at least one permanent first molar. Characterized by high porosity and reduced mineral content, MIH leads to hypersensitivity, post-eruptive breakdown, and increased caries susceptibility. The etiology is multifactorial, typically occurring between birth and four years of age. Management depends on severity, ranging from topical fluorides and sealants for mild cases to stainless-steel crowns or extractions for severe instances. Because porous enamel facilitates bacterial penetration and pulpal inflammation, achieving effective local anesthesia is often difficult, necessitating individualized behavioral management and early intervention to preserve tooth structure.
Turning Your Membership Into Measurable Value, Reva Darling
Turning Your Membership Into Measurable Value, Reva Darling
The Journal of the Michigan Dental Association
MDA membership offers significant financial leverage by negotiating programs that return money to dental practices. In 2025, practices utilizing endorsed vendors realized potential annual savings exceeding $50,000. Highlighted services include MEDVA, which provides virtual assistants to reduce salary expenses by over 60%, and PPO Negotiation Solutions, which has increased some practices' collections significantly. Members also benefit from discounts on dental supplies (TDSC.com), accounting services, and precious metal refining. Furthermore, Bridge Commercial Realty assists with real estate transitions, offering fee discounts and free appraisals. Collectively, these endorsed programs are designed to offset membership dues and strengthen a practice's financial health.
Advancing Inter-Brain Synchrony Measurement: A Comparative Hyperscanning Study Of Diffuse Optical Tomography And Functional Near-Infrared Spectroscopy, Shuo Guan, Yuhang Li, Yingbo Geng, Dongyun Li, Qiong Xu, Peisong Niu, Dalin Yang, Adam Eggebrecht, Yingchun Zhang, Rihui Li
Advancing Inter-Brain Synchrony Measurement: A Comparative Hyperscanning Study Of Diffuse Optical Tomography And Functional Near-Infrared Spectroscopy, Shuo Guan, Yuhang Li, Yingbo Geng, Dongyun Li, Qiong Xu, Peisong Niu, Dalin Yang, Adam Eggebrecht, Yingchun Zhang, Rihui Li
2020-Current year OA Pubs
Inter-brain synchrony (IBS), measured by hyperscanning, refers to the synchronization of multiple individuals' brain activities during social interactions. Traditional fNIRS-based hyperscanning suffers shortcomings like low spatial resolution and high susceptibility to superficial interference, causing imprecise estimation of IBS in complex social tasks. This study aims to fill the knowledge gap by comprehensively assessing diffuse optical tomography (DOT), an enhanced alternative to fNIRS, can benefit hyperscanning studies of complex social interactions. Sixteen dyads were engaged in both collaborative and individual tangram puzzle tasks, and their brain activities were recorded simultaneously using DOT and fNIRS. We found that DOT demonstrated significantly stronger …
Improving Pid Control With Bayesian Optimization For Adversarially Robust Federated Learning, Adrian Pena, Sergei Chuprov, Raman Zatsarenko, Leon Reznik
Improving Pid Control With Bayesian Optimization For Adversarially Robust Federated Learning, Adrian Pena, Sergei Chuprov, Raman Zatsarenko, Leon Reznik
Computer Science Faculty Publications
Federated Learning (FL) often suffers from unstable convergence and reduced robustness under non-IID data and malicious attacks. In this paper, we present FedPIDAvg_tuned, a control-theoretic aggregation framework for improving stability and adversarial robustness in FL. In particular, our approach combines a server-side Proportional–Integral–Derivative (PID) controller with Bayesian optimization to tune controller gains for different data and attack conditions. The PID controller regulates global model updates through feedback on loss dynamics, providing adaptive scaling that improves stability and convergence. The tuned gains are applied within a trust-weighted trimmed-mean mechanism to remove adversarial or outlier updates. Using the Flower framework, we evaluate …
Dgamlss: An Exact, Distributed Algorithm To Fit Generalized Additive Models For Location, Scale, And Shape For Privacy-Preserving Population Reference Charts, Fengling Hu, Jiayi Tong, Margaret Gardner, Chris Adamson, Sophie Adler, Aaron F. Alexander-Bloch, Evdokia Anagnostou, Kevin M. Anderson, Ariosky Areces-Gonzalez, John Blangero
Dgamlss: An Exact, Distributed Algorithm To Fit Generalized Additive Models For Location, Scale, And Shape For Privacy-Preserving Population Reference Charts, Fengling Hu, Jiayi Tong, Margaret Gardner, Chris Adamson, Sophie Adler, Aaron F. Alexander-Bloch, Evdokia Anagnostou, Kevin M. Anderson, Ariosky Areces-Gonzalez, John Blangero
Human Genetics Publications
Motivation There is growing interest in estimating population reference ranges across age and sex to better identify atypical clinically-relevant measurements throughout the lifespan. For this task, the World Health Organization recommends using Generalized Additive Models for Location, Scale, and Shape (GAMLSS), which can model non-linear growth trajectories under complex distributions that address the heterogeneity in human populations. Fitting GAMLSS models requires large, generalizable sample sizes, especially for accurate estimation of extreme quantiles, but obtaining such multi-site data can be challenging due to privacy concerns and practical considerations. In settings where patient data cannot be shared, privacy-preserving distributed algorithms for federated …
Phase I Trial Of Adp-A2afp Tcr T-Cell Therapy In Patients With Advanced Hepatocellular Or Gastric Hepatoid Carcinoma, Tim Meyer, Benjamin R Tan, Et Al.
Phase I Trial Of Adp-A2afp Tcr T-Cell Therapy In Patients With Advanced Hepatocellular Or Gastric Hepatoid Carcinoma, Tim Meyer, Benjamin R Tan, Et Al.
2020-Current year OA Pubs
BACKGROUND & AIMS: Patients with advanced hepatocellular carcinoma (HCC) generally experience poor outcomes despite current therapies, necessitating the development of alternative treatments. ADP-A2AFP is an investigational autologous T-cell therapy with an affinity-enhanced T-cell receptor (TCR) targeting alpha-fetoprotein (AFP).
METHODS: We describe a phase I, open-label, first-in-human clinical trial of ADP-A2AFP (NCT03132792) in human leukocyte antigen-eligible participants with AFP-expressing HCC (or other tumor) not amenable to transplant/resection who progressed on, were intolerant to, or refused prior systemic therapy. Participants received lymphodepletion chemotherapy (cyclophosphamide 500 mg/m
RESULTS: Twenty-one participants, 20 with advanced HCC and one with gastric hepatoid carcinoma received ≥1 ADP-A2AFP …
Defining Radiological Healing In Perianal Fistulizing Crohn's Disease: A Topclass Global Expert Delphi Consensus, Easan Anand, Jalpa Devi, David H Ballard, Shivani Joshi, Phil Tozer, Ailsa Hart, Anna Antoniou, Parakkal Deepak, Jaap Stoker, Phillip Lung, Topclass Collaborative Authors
Defining Radiological Healing In Perianal Fistulizing Crohn's Disease: A Topclass Global Expert Delphi Consensus, Easan Anand, Jalpa Devi, David H Ballard, Shivani Joshi, Phil Tozer, Ailsa Hart, Anna Antoniou, Parakkal Deepak, Jaap Stoker, Phillip Lung, Topclass Collaborative Authors
2020-Current year OA Pubs
BACKGROUND & AIMS: Perianal fistulising Crohn's disease (pfCD) affects one-fifth of patients with Crohn's disease (CD), significantly affecting their quality of life. Magnetic resonance imaging is the gold standard for evaluating fistula healing in pfCD, but variability in radiological definitions hampers meaningful clinical interpretation and consistent trial design. This study aimed to establish an international consensus on the definition of radiological healing in pfCD.
METHODS: The study was conducted in 2 phases. Phase 1 involved a systematic review to identify magnetic resonance imaging-based variables and indices used to define healing in pfCD, assessing methodological quality using the COnsensus-based Standards for …
Atomic Models Of The Toxoplasma Cell Invasion Machinery, Jianwei Zeng, Yong Fu, Pengge Qian, Wei Huang, Qingwei Niu, Wandy L Beatty, Alan Brown, L David Sibley, Rui Zhang
Atomic Models Of The Toxoplasma Cell Invasion Machinery, Jianwei Zeng, Yong Fu, Pengge Qian, Wei Huang, Qingwei Niu, Wandy L Beatty, Alan Brown, L David Sibley, Rui Zhang
2020-Current year OA Pubs
Apicomplexan parasites, responsible for toxoplasmosis, cryptosporidiosis and malaria, invade host cells through a unique gliding motility mechanism powered by actomyosin motors and a dynamic organelle called the conoid. Here, using cryo-electron microscopy, we determined structures of four essential complexes of the Toxoplasma gondii conoid: the preconoidal P2 ring, tubulin-based conoid fibers, and the subpellicular and intraconoidal microtubules. Our analysis identified 40 distinct conoid proteins, several of which are essential for parasite lytic growth, as revealed through genetic disruption studies. Comparative analysis of the tubulin-containing complexes sheds light on their functional specialization by microtubule-associated proteins, while the structure of the preconoidal …
Beyond Numbers: Bridging Statistical Significance And Clinical Relevance In Healthcare Research, Maharaj Singh, Waheeda Khan, Mehreen Fatima
Beyond Numbers: Bridging Statistical Significance And Clinical Relevance In Healthcare Research, Maharaj Singh, Waheeda Khan, Mehreen Fatima
College of Nursing Faculty Research and Publications
Objective: This study aims to bridge the gap between statistical significance and clinical relevance using rigorous statistical methodologies applied to simulated healthcare data, thereby enhancing the translational value of research outcomes for patient‑centered care. Methods: A synthetic dataset representing 10,000 patients was generated, and descriptive statistics were applied to compare two treatment groups. Binary outcomes were predicted using both a logistic regression model and a neural network. Two‑tailed tests with a significant level of 0.05 were employed, utilizing SAS version 9.4 and IBM SPSS Statistics, Version 29.0 (IBM Corp., Armonk, New York, United States of America). Results: The simulated dataset …
New Student Convocation, Brady Poisal
The Performance Of Machine Learning Algorithms In Predicting Under-Five Anaemia In Tanzania, Henry Ofori Duah, Derrick Nyantakyi Owusu, Godwin G. Duah, Paul Shidende
The Performance Of Machine Learning Algorithms In Predicting Under-Five Anaemia In Tanzania, Henry Ofori Duah, Derrick Nyantakyi Owusu, Godwin G. Duah, Paul Shidende
College of Nursing Faculty Research and Publications
Aim
Anaemia in children under five remains a major public health concern, contributing significantly to global child morbidity and mortality. With the rise of machine learning (ML), novel opportunities exist to model and predict anaemia more effectively. This study aimed to evaluate and compare the performance of five ML algorithms in predicting anaemia among under-five children in Tanzania.
Methods
We conducted a secondary data analysis using the 2017 Tanzania Malaria Indicator Survey (TMICS). The dataset (n = 5906) was randomly split into training (70%) and test (30%) sets. Five ML algorithms, Linear Discriminant Analysis (LDA), Logistic Regression, Random Forest (RF), …
Modeling Clinical Relevance And Risk In Yttrium-90 Radioembolization Of The Liver: Lung Shunt Fraction Variability According To Imaging Modality, Cancer Type, And Tumor Size, M Allan Thomas, Tharun Alamuri, Ryan C Lee, Dan Giardina, John Karageorgiou, Naganathan Mani, Daniel A Braga, Christopher D Malone
Modeling Clinical Relevance And Risk In Yttrium-90 Radioembolization Of The Liver: Lung Shunt Fraction Variability According To Imaging Modality, Cancer Type, And Tumor Size, M Allan Thomas, Tharun Alamuri, Ryan C Lee, Dan Giardina, John Karageorgiou, Naganathan Mani, Daniel A Braga, Christopher D Malone
2020-Current year OA Pubs
PURPOSE: To test the hypothesis that lung shunt fraction (LSF) in yttrium-90 (
MATERIALS AND METHODS: This was a retrospective analysis of 354 consecutive cases from a 34-month period at a single institution. Cancer type (hepatocellular carcinoma [HCC] vs non-HCC) and maximum tumor size were tracked. LSF was computed from planar imaging (LSF
RESULTS: Median LSF was significantly different (all P < .001) among LSF
CONCLUSIONS: Despite significant variations with imaging modality and correction methods, consistent trends in LSF magnitude with cancer type and tumor size were still uncovered. The relative risk of observing clinically relevant LSF can be modeled for different liver tumor …