Digital Commons Network^™

An Artificial Intelligence Assisted Framework For Automated Quantified Root Canal Curvature Measurement On Periapical Radiographs, Ming-Yi Chen, Shih-Lun Chen, Yu-Jen Chang, Yuan-Jin Lin, Chiung-An Chen, Tsung-Yi Chen, Kuo-Chen Li, Wei-Chen Tu, Patricia Angela R. Abu

Journal of Dental Sciences

Background/purpose: Root canal curvature is a complex anatomical variation that complicates endodontic treatments. Traditionally, dentists rely on two-dimensional periapical radiographs (PA) and manual methods to estimate curvature angles. However, this conventional approach is highly time-consuming and subjective, often leading to inconsistent measurements.

Materials and methods: This study aims to develop a fully automated, objective framework for precise angular measurement and severity grading of root canal curvature. The YOLO26n-seg model was employed to segment roots and classify single- or multi-rooted teeth from PA. Furthermore, we proposed an image processing algorithm that standardized orientation, extracted centerlines, and applied three-point circle fitting …

Exosomes Derived From Bone Substitute-Induced Gingival Mesenchymal Stem Cells Promote Angiogenesis, Chongyu Shen, Zheng Guan, Rui Chu, Zhengyin Li, Jiangting Lu, Liangkun Xie

Journal of Dental Sciences

Background/purpose: In certain clinical bone grafting scenarios, bone substitutes frequently interface with the adjacent soft tissues. This study aimed to investigate whether deproteinized bovine bone mineral (DBBM) and coralline hydroxyapatite (CHA) induce paracrine responses in human gingival mesenchymal stem cells (GMSCs), thereby altering the pro-angiogenic capacity of their derived exosomes, and to profile specific cargo alterations.

Materials and methods: Exosomes were isolated from GMSCs co-cultured with DBBM (DBBM-G-EXO) or CHA (CHA-G-EXO), while native GMSCs-derived exosomes (G-EXO) were collected as controls. The angiogenic effects of these exosomes on human umbilical vein endothelial cells (HUVEC) were evaluated via cell proliferation, scratch wound …

Submicron Diamond-Assisted Irrigation Enhances Apical Biofilm Removal Under Sonic And Ultrasonic Activation: An Ex Vivo Study, Yung-Szu Hsu, Nai-Chia Teng, Sin-Yu Chen, Huan-Cheng Chang, Haw-Ming Huang, Sung-Chih Hsieh

Journal of Dental Sciences

Background/purpose:

Residual apical biofilm often persists despite sodium hypochlorite (NaOCl) irrigation with sonic or ultrasonic activation. Submicron diamond particles (SMD) have shown promise as a particle-assisted adjunct for root canal cleaning, but their effects on mature intracanal biofilm remain unclear. This study evaluated whether 500-nm SMD particles (10 mg/mL) improve the antibacterial and antibiofilm efficacy of saline or NaOCl irrigation against mature Enterococcus faecalis (E. faecalis) biofilms.

Materials and methods:

One hundred single-rooted human premolars infected with E. faecalis for 21 days were randomly allocated to ten irrigation protocols (n = 10). Antibacterial efficacy was assessed by …

Silencing The Mir-132/Sirt1 Axis Suppresses Nlrp3 Inflammasome Activation And Myofibroblast Differentiation In Oral Submucous Fibrosis, Ming-Yung Chou, Min Yee Ng, Yi-Wen Liao, Chuan-Hang Yu, Cheng-Chia Yu, Sin-Jia Tseng

Journal of Dental Sciences

Background/purpose

Oral submucous fibrosis (OSF) is a chronic oral potentially malignant disorder characterized by progressive extracellular matrix deposition, myofibroblast activation, oxidative stress, and inflammatory signaling. However, the upstream microRNA-mediated mechanisms linking fibrogenesis and NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome activation remain unclear. This study investigated the role of the miR-132/sirtuin 1  (SIRT1) axis in OSF-associated fibrotic and inflammatory responses.

Materials and methods

miR-132 expression was examined in OSF tissues, normal tissues, primary buccal mucosal fibroblasts (BMFs), and fibrotic buccal mucosal fibroblasts (fBMFs) using RNA sequencing and quantitative real-time PCR. Patient-derived fBMFs were transfected with a miR-132 inhibitor …

Biphasic Remodeling And Trabecular-Cortical Uncoupling In The Jawbone During Antiresorptive Therapy And Medication-Related Osteonecrosis: A Quantitative Imaging Analysis, Ling-Ying Wei, Jun-Ching Lee, Ching-Ming Chiu, Sang-Heng Kok, Hung-Ying Lin, Wei-Yih Chiu, Hao-Hueng Chang, Shih-Jung Cheng, Jang-Jaer Lee

Journal of Dental Sciences

Background/purpose: Although antiresorptive therapy (ART) is crucial for managing oncology-related skeletal complications, it carries a risk of medication-related osteonecrosis of the jaw (MRONJ). Because conventional radiography relies on subjective interpretation, detecting early necrotic transition remains challenging. This study aimed to establish objective, quantitative imaging criteria for jawbone remodeling and MRONJ onset by evaluating 2D fractal dimension (FD) and 3D CBCT cortical thickness under zoledronic acid or denosumab therapy.

Materials and methods: Panoramic radiographs and CBCT scans of cancer patients receiving zoledronic acid (ZA, n = 155) or denosumab (Dmab, n = 168), and healthy controls (n = 95) were analyzed. …

A Scientometric Study On Research Trends And Characteristics Of Kimura Disease, Zhongjing Lv, Yiming Luo, Wei Liu, Jian Yuan

Journal of Dental Sciences

Background/purpose: Kimura disease (KD) is an idiopathic condition that presents as a chronic, benign inflammatory disorder, typically affecting the head and neck region. The purpose of this study was to analyze the scientometric characteristics and research trends of KD.

Materials and methods: All the papers on KD were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2012 and after 2012 in the analysis of research trends.

Results: There were 925 papers on KD, with total citations of 10,821 and the h index of 47. Eosinophilia, lymphadenopathy, nephrotic syndrome, angiofollicular lymph node hyperplasia, …

Artificial Intelligence In Dentistry: A Cross-Domain Bibliometric Analysis Of Technologies, Functional Applications, And Dental Specialties, Yinghui Yang, Cheng-Chia Yu, Min Yee Ng

Journal of Dental Sciences

Background/purpose: Artificial intelligence is increasingly applied in dentistry across diagnosis, prediction, treatment planning, education, and patient communication. This study aimed to provide a structured cross-domain overview of dental AI research by integrating AI technologies, functional applications, and dental specialties within one bibliometric framework.

Materials and methods: AI-related dental publications from 2016 to 2026 were retrieved from the Web of Science Core Collection. Original and review articles were screened and classified by AI technology, functional application, and dental specialty. Bibliometric mapping, collaboration analysis, keyword co-occurrence, and heatmap-based cross-domain visualization were performed.

Results: A total of 920 publications were included. Publication …

Keratin 18 As A Cytoskeletal Regulator Of Epithelial–Mesenchymal Plasticity And Prognostic Risk In Oral Squamous Cell Carcinoma, Tuan-Yu Kao, Hsuan-Chao Lin, Chien-Wei Lai, Julia Yu-Fong Chang, Feng-Chiao Tsai, Jang-Jaer Lee, Jean-San Chia

Journal of Dental Sciences

Background/purpose: Oral squamous cell carcinoma (OSCC) shows poor survival, and conventional staging does not fully capture biologic aggressiveness. Keratin 18 (KRT18) has been linked to malignant progression in epithelial cancers, but its prognostic and biologic significance in OSCC remains unclear. This study investigated whether KRT18 expression is associated with aggressive invasion patterns and adverse outcomes in OSCC, and whether KRT18 contributes to epithelial–mesenchymal plasticity-related malignant phenotypes.

Materials and methods: Eighty-eight non-irradiated OSCC specimens obtained after primary surgical resection at National Taiwan University Hospital were analyzed by immunohistochemistry. Associations between KRT18 expression and clinicopathological variables were assessed, and survival was evaluated …

Anemia, Hematinic Deficiencies, And Gastric Parietal Cell Antibody Positivity In Recurrent Aphthous Stomatitis Patients With Or Without Hyperhomocysteinemia, Yi-Ping Wang, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous study found that 42 of 430 recurrent aphthous stomatitis (RAS) patients have hyperhomocysteinemia. This study assessed whether these 42 RAS patients with hyperhomocysteinemia (hyperhomocysteinemia/RAS patients) had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 388 RAS patients without hyperhomocysteinemia (non-hyperhomocysteinemia/RAS patients) or 430 healthy control subjects.

Materials and methods: The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 42 hyperhomocysteinemia/RAS patients, 388 non-hyperhomocysteinemia/RAS patients, and 430 healthy control subjects were measured and compared.

Results: We found that 42 hyperhomocysteinemia/RAS patients had significantly …

Very Early Interceptive Management Of Class Iii Malocclusion In Primary Dentition Using A Prefabricated Functional Education Appliance: Preliminary Clinical Observations, Thi Ngoc Anh Do, Thi Huong Le, I-Ta Lee, Tong-Hsien Chow, Pao-Chang Chiang, Thi Thuy Tien Vo

Journal of Dental Sciences

Background/purpose: Class III malocclusion with anterior crossbite in primary dentition may progress and complicate future orthodontic treatment. This short communication presents preliminary clinical observations of very early interception using a prefabricated functional education appliance.

Materials and methods: Three children aged 4 to 6 years with dental, functional, or mild skeletal class III malocclusion were treated using a prefabricated removable functional education appliance worn at night, with regular follow-up.

Results: In the dental class III case, anterior crossbite was corrected within 9 months and remained stable at the 2-year follow-up. In the functional class III case, anterior crossbite and mandibular shift …

A Scientometric Study On Research Trends And Characteristics Of Lymph Node Metastasis In Oral Cancer, Linjian Huang, Xiaocui Tong, Wei Liu, Xinyu Zhang

Journal of Dental Sciences

Background/purpose: Cervical lymph node metastasis (LNM) is the most critical prognostic factor in oral cancer (OC) patients. The purpose of this study was to analyze the scientometric characteristics and research trends of LNM in OC.

Materials and methods: All the papers on LNM in OC were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2016 and after 2016 in the analysis of research trends.

Results: There were 946 papers on LNM in OC, with total citations of 21,154 and the h index of 70. The trend of clinical aspect including lymph …

Oral Health Knowledge Across Cultural Boundaries: A Physiology And Hygiene Textbook From The Tamsui Middle School During The Japanese Colonial Period, Hung-Lun Pan, Feng-Chou Cheng, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Application Of Medical Imaging Examinations For Temporomandibular Disorders Under Taiwan's National Health Insurance System, Feng-Chou Cheng, Mu-Hsiung Chen, Yu-Ling Wu, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Light-Curing Staining Materials And Application Techniques For Dental Resin Restorations, Fu-Chuan Tsai, Kuo‑Ning Ho, Yu-Chieh Lin, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Topical Fluoride Treatment For Irradiated Head And Neck Cancer Patients Under Taiwan's National Health Insurance System, Feng-Chou Cheng, Mu-Hsiung Chen, Sheau-Jing Yu, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Microsurgical Management Of Non-Union Mid-Root Fractures In Endodontically Treated Maxillary Incisors: A Case Report With 2-Year Follow-Up, Saeed Asgary

Journal of Dental Sciences

No abstract provided.

Maximizing Tooth Preservation In Persistent Apical Periodontitis Using Selective Root Resection And Calcium-Enriched Mixture (Cem) Cement: A Case Report, Saeed Asgary

Journal of Dental Sciences

No abstract provided.

The Evolution Of Artificial Intelligence And Deep Learning In Removable Partial Denture Design, Fu-Chuan Tsai, Hsin-Hua Chou, Takashi Saito, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Artificial Intelligence-Powered Chatbots’ Responses To Orthodontic Questions From The Dentistry Specialization Examination: Accuracy And Source Evaluation, Berrak Çakmak, Tevhide Sökmen,, Burcu Balos‚ Tuncer

Journal of Dental Sciences

No abstract provided.

The Clinical Potential Of Cone-Beam Computed Tomography Image Segmentation In Dentistry, Hsin-Hua Chou, Takashi Saito, Chih-Kai Huang, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Digital Impression Workflows And Mucosal Considerations In Removable Complete Dentures, Fu-Chuan Tsai, Hsin-Hua Chou, Takashi Saito, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Virtual Patient Technology Enabled The Reconstruction Of Craniofacial Hard And Soft Tissues Through The Integration And Superimposition Of Multimodal Dental Imaging Datasets, Hsin-Hua Chou, Kuo‑Ning Ho, Takashi Saito, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Roles And Functions Of The Dental Division At The National Taiwan University Cancer Center, Feng-Chou Cheng, Yu-Jie Shen, Shu-Yu Liu, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Exploring Exhibited Works On Dentistry-Related Topics At The Student Science Fair Projects In Taiwan From 1970 To 2025, Mei-Huei Li, Feng-Chou Cheng, Kun-Ming Lien, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Ruptured Silicone Cheek Implant Mimicking Odontogenic Infection: A Diagnostic Pitfall, Kimiko Ohgi, Tomoko Shiraishi, Toyohiro Kagawa, Yasunori Yoshinaga

Journal of Dental Sciences

No abstract provided.

Radiographic Signs Of Numb Chin Syndrome As An Initial Indicator Of Burkitt Lymphoma: A Case Report, Yu-Hsiang Tang, Meng-Ling Chiang, Jyh-Kwei Chen

Journal of Dental Sciences

No abstract provided.

Maxillary Furcation-Involved Class Ii Subclass B Molar With Advanced Distal Vertical Bone Defect Treated By Er:Yag Laser-Assisted Comprehensive Periodontal Pocket Therapy Under A Microscope: A Case Report, Taichen Lin, Yoichi Taniguchi, Koji Mizutani, Akira Aoki

Journal of Dental Sciences

No abstract provided.

Recurrent Maxillary Medication-Related Osteonecrosis Of The Jaw With Maxillary Sinusitis In An Edentulous Patient: A Possible Bidirectional Relationship, Wun-Ting Lin, Yu-Nung Lee, Yu-Fen Yen, Ken-Chung Chen

Journal of Dental Sciences

No abstract provided.

Comment On “Zygomatic Fracture Characteristics And Their Association With Brain Injury: Evidences From A 10-Year Retrospective Study In Northern Taiwan”, Yang-Zhou Huang, Kun Zhao, Jing Xiao, Zhou-Hui Wu

Journal of Dental Sciences

No abstract provided.

Corrigendum To "Human Umbilical Cord Mesenchymal Stem Cells Secretome And Nanoemulsion Propolis Combination Ameliorate Osteoclastogenesis In Lipopolysaccharide-Induced Osteolysis In Hyperglycemia Rats"

Journal of Dental Sciences

No abstract provided.