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Managing The Legacy Of Historical Land Use In Central Appalachia: Soil Health, Carbon Storage, And Restoration Across Disturbed Ecosystems, Kyra R. Dukich

Graduate Theses, Dissertations, and Problem Reports (ETD)

Historical mining, intensive timber harvesting, agriculture, and atmospheric acid deposition have left lasting impacts on soil health throughout the Central Appalachian region, reducing soil productivity, carbon storage, and ecosystem resilience. This thesis evaluated restoration strategies across two long-term research systems in West Virginia to determine how land-use history and soil amendments influence soil health, carbon dynamics, and ecosystem recovery. The first study examined reclaimed mine lands and marginal agricultural soils planted with switchgrass (Panicum virgatum) or willow (Salix spp.) and treated with biochar or inorganic fertilizer. Soil greenhouse gas production, aggregate stability, total soil C:N, pH, and soil organic matter …

Dataless Neural Networks For Boolean Satisfiability And Network Optimization, Andrew Evan Gautier

Graduate Theses, Dissertations, and Problem Reports (ETD)

Combinatorial optimization problems (COPs) require searching over a finite solution space subject to constraints, with the goal of satisfying an objective function. They arise in operations research, scheduling, resource allocation, circuit design, and many other fields. Many problems in combinatorial optimization (including satisfiability and network design) are NP-hard. Traditionally, researchers have built approximate solvers that return near- optimal solutions efficiently by developing increasingly sophisticated heuristics and meta- heuristics. Deep learning has provided new opportunities for improving combinatorial solvers by leveraging neural guidance to prune the search space. Traditional neural networks have distinct drawbacks in this context: separate training and …

Sdrc Update (Volume 7, Issue 1), Joanna Cayton-Velante

SDRC Publications

No abstract provided.

Sdrc Update (Volume 6, Issue 2), Dlsu Social Development Research Center

SDRC Publications

No abstract provided.

The Hidden Costs Of Consumption: A Multi-Context Investigation On Stigma And Social Judgment, Siti Nuraisyah Suwanda

Graduate Theses, Dissertations, and Problem Reports (ETD)

Consumption is not always as simple as an exchange of value between a buyer and a seller. In many contexts, what individuals choose to consume or not consume can carry social meaning, leading to judgment and devaluation. While prior research has explored stigma broadly in marketing and consumer behavior, less attention has been given to stigma that caused specifically by consumption choices. This dissertation addresses this gap by examining how consumption becomes socially evaluated and judged across different contexts, with the goal of advancing both theoretical understanding and practical insights into socially sensitive consumption.

Essay One develops the foundation by …

Stakeholder Perceptions Of West Virginia’S Artificial Food Dye Ban In K–12 School Meals: Initial Year Of 2025-2026, Leah Michelle Rogers

Graduate Theses, Dissertations, and Problem Reports (ETD)

OBJECTIVES: Artificial food dyes (AFD+) are an increasing policy concern in the U.S., particularly in children’s foods. West Virginia’s House Bill 2354, the first statewide AFD+ ban implemented in K-12 schools, restricts seven AFD+ in state-funded meals. Little is known about how AFD+ bans are perceived or implemented. This study examined how the ban functioned within school food systems and the barriers and facilitators experienced by school stakeholders within the initial year of implementation during the 2025-2026 school year.

METHODS: A cross-sectional, observational mixed-methods study was conducted among implementers, enforcers, and receivers of the policy. A survey tool …

Reforma Alutsista Dan Sumber Daya Alam: Menjawab Tantangan Hukum Internasional Dan Perdamaian Dunia, Wildan Azkal Fikri, Rohadhatul Aisy

Jurnal Hukum & Pembangunan

This study departs from the paradox of the failure to achieve world peace despite the existence of an established international legal regime. It addresses three main objectives: (1) identifying the key factors that undermine world peace; (2) analyzing the failure factors of international law to realize global peace; and (3) formulating a responsive international legal architecture to future peace agendas. The study employs a critical descriptive method with a socio-legal (non-doctrinal) approach, drawing on the analytical frameworks of neorealism, great powers oligarchy, and Third World Approaches to International Law (TWAIL). The qualitative analysis is conducted by examining power relations, the …

Implementasi Land Freezing Di Kabupaten Kutai Kartanegara Dan Penajam Paser Utara: Antara Pengendalian Pertanahan Dan Pelindungan Hak Keperdataan, Anggita Mustika Dewi, Destriananda Safa Aina, Ananda Mulia Putri Maharani

Jurnal Hukum & Pembangunan

To prevent land speculation by land mafias in the Nusantara Capital City (IKN), the government introduced a land-freezing policy aimed at restricting the transfer of land rights within the IKN area. However, in practice, this policy has been alleged to hinder land registration processes and undermine civil rights of communities within the IKN delineation zone. This study seeks to examine the regulatory framework, implementation, and impacts of the land-freezing policy on land registration and the civil rights of affected communities. Employing an empirical normative legal research method with a statute approach, this research finds that the land-freezing policy has not …

Mathematicly Rigorous Quantum General Relativity, I: Pure, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

A pure quantum general relativity field is one lacking in matter. Such a field has a Lorentzian space-time geometry. A renormalized perturbation expansion, truncated to all finite orders, establishes  the existence of pure quantum general relativity with full mathematical rigor

Quantum General Relativity V2, James Glimm, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

We construct a quantum general relativity theory.. The construction includes specification of a cosmological model. Based on type Ia supernova data, the model has zero dark energy and zero cosmological constant.

The analysis is at the level of theoretical physics, with some mathematical details omitted.

The Pure Yang-Mills Field, \, Iia: The Axioms, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

A previously constructed pure Yang-Mills quantum gauge field theory is shown to satisfy all Osterwalder Schrader axioms.

Brst Conserved Moments For Fluids, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

This note adds a missing proof for an assertion in the original paper Gauge Invariance and Repeated Time Isolated Solution Discontinuities.

The assertion is that under weak limits and within a constant energy isosurface, enstrophy is conserved up to losses due to viscous dissipation.

According to the BRST theory for quantum Yang-Mills fields, the conserved moments are exactly those with infinite vacuum expectation values. Application of the BRST theory to fluids is explored. The BRST restriction to the loop expansion (fixed space) is justified by the reqirement that a perturbative expansion can be constructed. In this case the theory predicts …

Mathematicly Rigorous Quantum General Relativity, I: Pure, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

A pure general relativity (quantum or classical) is one lacking in matter. Such a field has a Lorentzian space time geometry. A renormalization perturbative expansion, truncated to all finite orders, establishes both the quantum and the general relativity theory with full mathematical rigor.

The Pure Yang-Mills Field. I: Eistence, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

Two pure Yang-Mills quantum gauge field theories are constructed, one based on short distance asymptotics and the other based on long distance asymptotics.

The construction is based on the axial gauge, ghost states, the BRST framework and Gribov extension of the Hamiltonian, with a loop expansion cutoff to all finite orders for the dynamics.

The construction is established by renormalized perturbation theory to all finite orders.

The construction depends on an assumed principle of a maximum rate of entropy production

Weak Solutions Of The Navier-Stokes Equation And Their Euler Limits, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

The existence of a weak solution of the incompressible isothermal Navier-Stokes equation with given initial conditions in the Sobolev space $\mathcal{H}_{-2}$ for energy fluctuations and in $\mathcal{H}_{-3}$ for enstrophy fluctuations is assumed. The existence is uniform with respect to the Euler limit of zero viscosity $\nu$. Thus, existence of weak solutions of the Euler equation with given initial conditions is established, and these Euler solutions are the zero viscosity limit of Navier-Stokes solutions, provided the Navier-Stokes solutions exist.

The Boson Yang-Mills Field: The Loop Expansion, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

This paper demonstrates convergence of the loop expansion for Yang-Mills fields.

The loop construction of perturbation theory is based on the axial gauge, ghost states, the BRST framework and the Gribov extension of the Hamiltonian, with the loop expansion perturbatively renormalizable.

The construction is established by renormalized perturbation theory convergent to all finite orders.

Two distinct Yang-Mills theories are constructed, one based on short distance asymptotics and the other based on long distance asymptotics.

The construction depends on an assumed principle of a maximum rate of entropy production.

The paper has sufficient generality to include existence for all cases that …

Infant Sensory Gating And A Developmental Cascade To Autistic Traits And Anxiety, Rebecca F Schwarzlose

2020-Current year OA Pubs

Disruptions to the infant sensory environment can have lasting effects on neural response properties and behavior in both humans and animals. Recent work has begun to highlight an additional factor in infant sensory experience: differences in inhibitory signaling and sensory gating. Converging work from human and animal studies has begun to implicate a developmental cascade by which impaired sensory gating during a sensitive period of neonatal neurodevelopment promotes a phenotype of sensory over-responsivity, autistic traits, anxiety, and other psychiatric challenges. In this Review, I propose a model for this developmental cascade and highlight how differences in infant sensory responsivity represent …

Steroid Hormone Metabolites And Mammographic Breast Density In Premenopausal Women, Ghazaleh Pourali, Kayode A Matthew, Myung Sik Jeon, Chongliang Luo, Gary J Patti, Jingqin Luo, Adetunji T Toriola

2020-Current year OA Pubs

BACKGROUND: Steroid hormones influence breast morphology and cellular proliferation and are associated with breast carcinogenesis. However, their associations with mammographic breast density (MBD) are less studied, particularly in premenopausal women. We, therefore, investigated the associations of steroid hormone metabolites with MBD in premenopausal women.

METHODS: Our study included 700 premenopausal women scheduled for screening mammograms. We analyzed 54 steroid hormone metabolites (Metabolon®) and assessed volumetric measures of MBD including volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV) using Volpara. We investigated associations using linear regression modeling to estimate the covariate-adjusted means of VPD, NDV, and DV, corresponding …

Preparing For Long-Acting Technologies: A Multistate Analysis Of Prep Persistence And Hiv And Sti Lab Coverage Among Oral Prep Initiators In St. Louis, Missouri (2014-2021), Lindsey M Filiatreau, Rupa Patel, Kate Curoe, Ashley Underwood, Joseph Cherabie, Elvin H Geng, Aditi Ramakrishnan, Rachel Presti, Aaloke Mody

2020-Current year OA Pubs

BACKGROUND: Engagement in pre-exposure prophylaxis (PrEP) care and routine screening for HIV and sexually transmitted infections (STIs) is critical to realizing the full benefits of this HIV prevention strategy.

METHODS: We enrolled a cohort of individuals seeking PrEP services in two clinics in Missouri, an Ending the HIV Epidemic priority state, from June 2014 to November 2021. We used electronic health record and survey data to explore outcomes in the 2 years following linkage to care using multistate methods. We assessed transitions between eight mutually exclusive care states differentiated by receipt of a prescription, lab coverage status, and retention. We …

Intraoperative Neurophysiological Monitoring In Full-Endoscopic Cervical Endoscopic Ulbd, Miles Hudson, Sarah Esposito, Mark M Zaki, Simon M Glynn, Osama N Kashlan, John Ogunlade, Chandan Krishna, Joshua Bakhsheshian, Christoph P Hofstetter

2020-Current year OA Pubs

No abstract provided.

Epithelial-Mesenchymal Transition And Stress Adaptations Underlie Yttrium-90 Resistance In Liver Cancer Cell Lines, Alexander Zheleznyak, Dhanusha Duraiyan, Prasanth Thunuguntla, Jessica Camacho, Shuang Wu, Jingxia Liu, Jason D Weber, Daniel L J Thorek, Benjamin S Strnad, Ryan C Fields, Matthew A Ciorba, Christine Yoon, Valerie Blanc, Nicholas Davidson, Jessica Silva-Fisher, Christopher D Malone

2020-Current year OA Pubs

UNLABELLED: Molecular signatures predict prognosis in hepatocellular carcinoma, but their relevance to transarterial radioembolization (TARE) with yttrium-90 (90Y) is unknown. We aimed to identify baseline and treatment-induced pathways associated with response and nominate biomarkers. Ten transcriptomically diverse human liver cancer cell lines were exposed to escalating activities of glass 90Y microspheres for 10 days. Normalized AUC values quantified sensitivity. Whole-transcriptome RNA sequencing at baseline and after treatment was analyzed with elastic net regression and gene set enrichment. Findings were corroborated by qRT-qPCR and exploratory analysis of pretreatment tumor samples from patients undergoing TARE. Liver cancer cell line responses to 90Y …

The Cognitive-Affective Social Processing And Emotion Regulation (Casper) Model, M Catalina Camacho, Elina Deshpande, Michael T Perino

2020-Current year OA Pubs

Humans are intensely social creatures. It is therefore not surprising that many psychiatric disorder criteria include social dysfunctions; however, overlapping presentations and diverse, complex etiologies make treating social dysfunctions difficult. Here, we introduce the Cognitive Affective Social Processing and Emotion Regulation (CASPER) model. CASPER integrates research from social psychology, cognitive neuroscience, and developmental science to describe how real-world social processing unfolds and is associated with differing psychiatric social cognitive neurophenotypes. Briefly, social processing can be broken down into the following cognitive steps: identifying relevant social cues, attending to related cues, interpreting cues, and adjusting behavior appropriately. Each of these steps …

A Microenvironment-Driven Hla-Ii-Associated Insulin Neoantigen Elicits Persistent Memory T Cell Activation In Diabetes, Neetu Srivastava, Anthony N Vomund, Rongzhen Yu, Orion J Peterson, Yuqing Yang, David P Turicek, Omar Abousaway, Tiandao Li, Pamela Stone, Aisha Ansar, Rima Melhem, Bo Zhang, Chang Liu, Hao Hu, Chyi-Song Hsieh, Laura Campisi, Emil R Unanue, Ana Maria Arbelaez, Cheryl F Lichti, Xiaoxiao Wan, Et Al.

2020-Current year OA Pubs

The antigenic landscape of autoimmune diabetes reflects a failure to preserve self-tolerance, yet how novel neoantigens emerge in humans remains incompletely understood. Here we designed an immunopeptidomics-based approach to probe HLA-II-bound, islet-derived neoepitopes in patients with type 1 diabetes. We uncovered a Cys→Ser transformation, conserved between mice and humans, that reshapes autoreactivity to insulin at the single-residue level. This transformation, which we call C19S, arises from oxidative remodeling of insulin in stressed pancreatic islets and also occurs in cytokine-activated antigen-presenting cells, contributing to a feed-forward loop of neoepitope formation and presentation. Despite involving just one amino acid, C19S is recognized …

Frontline Aspiration Versus Stent Retriever Thrombectomy For M2 Occlusions: Insights From The Star Registry, Michael Gaub, Joshua Osbun, Et Al.

2020-Current year OA Pubs

BACKGROUND: Recent trials have furthered uncertainty regarding the endovascular benefit for medium vessel occlusions (MeVO). Stent retrievers (SR) were employed in the first attempt in most interventional arm participants. We sought to compare outcomes in acute MCA M2 occlusions between frontline aspiration and SR, and to delineate procedural and anatomical covariates associated with differential treatment effect.

METHODS: Retrospective analysis of a multicenter stroke thrombectomy cohort identified cases of MT for M2 occlusions. Unmatched and propensity score-matched (PSM) cohorts were generated comparing frontline aspiration to standalone and combined SR. The primary outcome was functional independence (mRS 0-2) at 90 days. Recanalization, …

Phase I Trial Of Adp-A2afp Tcr T-Cell Therapy In Patients With Advanced Hepatocellular Or Gastric Hepatoid Carcinoma, Tim Meyer, Benjamin R Tan, Et Al.

2020-Current year OA Pubs

BACKGROUND & AIMS: Patients with advanced hepatocellular carcinoma (HCC) generally experience poor outcomes despite current therapies, necessitating the development of alternative treatments. ADP-A2AFP is an investigational autologous T-cell therapy with an affinity-enhanced T-cell receptor (TCR) targeting alpha-fetoprotein (AFP).

METHODS: We describe a phase I, open-label, first-in-human clinical trial of ADP-A2AFP (NCT03132792) in human leukocyte antigen-eligible participants with AFP-expressing HCC (or other tumor) not amenable to transplant/resection who progressed on, were intolerant to, or refused prior systemic therapy. Participants received lymphodepletion chemotherapy (cyclophosphamide 500 mg/m

RESULTS: Twenty-one participants, 20 with advanced HCC and one with gastric hepatoid carcinoma received ≥1 ADP-A2AFP …

Cutibacterium Adaptation To Life On Humans Provides A Potential C Acnes Infection Biomarker, Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H Mccoy 4th

2020-Current year OA Pubs

Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C acnes) now dominates 25% of human skin. C acnes colonization of human skin requires the protein RoxP. Although all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. In this study, we report an extensive assessment of 21 RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C acnes dominate …

Mutations In Hsp40 Co-Chaperone Change The Canonical Interdomain Interactions Stimulating Lgmdd1 Myopathy, Ankan K Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Daniel Chen, Jil Daw, Conrad C Weihl, Heather L True

2020-Current year OA Pubs

Limb-girdle muscular dystrophy D1 (LGMDD1) is a rare, dominantly inherited neuromuscular protein-misfolding chaperonopathy caused by mutations in the Hsp40 co-chaperone DNAJB6, primarily in the glycine-phenylalanine (GF) or J-domains. Currently, no treatments are available, and a challenge in understanding the disease is identifying a specific client protein for DNAJB6 in skeletal muscle. DNAJB6 has homology to the yeast DNAJ family member, Sis1. Our previous research indicated that LGMDD1 GF domain mutants in Sis1 exhibit substrate-specific effects, influenced by Hsp70 activity. Herein, we employed functional assays along with advanced molecular simulation studies to understand the regulatory interdomain interactions in disease-causing mutants of …

Diverse Misfolding Mutant Digestive Enzymes Cause Chronic Pancreatitis Through Common Pathways, Steven J Wilhelm, Grace E Curry, Neel Matiwala, Jianguo Lin, Tran Quach, Mark E Lowe, Miklós Sahin-Tóth, Xunjun K Xiao

2020-Current year OA Pubs

BACKGROUND & AIMS: Increasing evidence suggests that protein misfolding and proteotoxicity is an important mechanism of chronic pancreatitis (CP) in patients with genetic variants. Two mouse models carrying misfolding digestive enzyme variants, CPA1 N256K and PNLIP T221M, recapitulate the human CP phenotype. We hypothesized that both models develop CP through similar disease mechanisms.

METHODS: We conducted a comprehensive analysis of mice aged 1 to 6 months using histology, immunohistochemistry, protein immunoblotting, quantitative polymerase chain reaction (qPCR), transmission electron microscopy (TEM), and RNA sequencing (RNA-seq) analysis to characterize pancreatic pathological changes.

RESULTS: Both homozygous models exhibited CP hallmarks, including progressive acinar …

Airway Management In Emergency Department Thoracotomy: A Narrative Review, Aaron J Lacy, Adam Liebendorfer, Sarah M Guess, Rami S Al-Aref, Anthony P Kronfli, Rachel E Armstrong, Amelia W Maiga, Alexander Bracey, Ryan N Barnicle

2020-Current year OA Pubs

INTRODUCTION: Emergency department thoracotomy (EDT) is a high-risk, life-saving intervention for patients in traumatic cardiac arrest. A critical component of EDT is airway management, typically performed by emergency physicians, yet formal guidance regarding optimal strategies remains limited. Airway management in this setting is uniquely complex due to concurrent anatomic injury, physiologic instability, and the procedural demands of thoracotomy.

DISCUSSION: Endotracheal intubation (ETI) during EDT presents multiple challenges. Anatomic difficulties may arise from facial or cervical trauma, restricted positioning, and the presence of cervical collars. Cognitive load is heightened by the chaotic, multidisciplinary environment, requiring strategies such as pre-briefing, checklists, and …

Foot-Specific Exercise Intervention For Forefoot Deformity In Individuals With Type 2 Diabetes And Peripheral Neuropathy: A Randomized Controlled Clinical Trial With 3-Year Follow-Up, J A Zellers, K Steger-May, P K Commean, H-J Jeong, E M Bullard, M J Mueller, M K Hastings

2020-Current year OA Pubs

BACKGROUND: Diabetes with peripheral neuropathy can lead to metatarsophalangeal joint (MTPJ) deformity. The purpose of this study was to estimate the effect of a foot-specific intervention on MTPJ deformity. Secondary aims were determining MTPJ deformity progression over 3 years and predictors of MTPJ deformity progression.

METHODS: Sixty people with type 2 diabetes and peripheral neuropathy were recruited for this randomized controlled clinical trial. Participants were assessed at baseline, 6 months (post-intervention), 1.5 years, and 3 years. A 6-month, foot-specific intervention in the experimental group was compared to a shoulder intervention in the control group. The primary outcome was change in …