Digital Commons Network^™

Clinical Subtypes Of Co-Morbid Insomnia And Obstructive Sleep Apnea (Comisa): Results Of A Cluster Analysis, Yuan Shi, Xujun Feng, Fengyi Hao, Yuru Nie, Yihui Zhang, Zhaohua Chen, Siqi Guan, Larry D. Sanford, Michael V. Vitiello, Xiangdong Tang

Department of Pathology & Anatomy Faculty Publications

Background

Variations in the bidirectional relationship between obstructive sleep apnea (OSA) and insomnia in co-morbid insomnia and OSA (COMISA) may form distinct subtypes of COMISA, which have not been previously characterized. This study aims to identify and characterize subtypes of COMISA.

Methods

From a community-recruited COMISA cohort 256 individuals who met diagnosis for COMISA were used to identify subtypes using a two-step clustering methodology. Demographics and multidimension clinical characteristics were collected and compared among obtained subtypes. Logistic models were used to evaluate whether these subtypes were associated with cardiometabolic and mental disorders. A clinical cohort of 1816 COMISA patients was …

The Rna-Binding Protein Pumilio Limits Polymodal Noiception In Drosophila Larvae, Sara Palega, Hannah Davenport, Rebeccah K. Stewart, Jessica Horton, Andrew Bellemer

Microbiology & Molecular Cell Biology Faculty Publications

Nociception is the process by which the nervous system detects and processes information about potentially harmful environmental stimuli to generate behavioral and physiological responses. The process of nociception undergoes plasticity in response to injury, inflammation, and infection to shape the sensitivity of nociceptive circuits and the behavioral responses they control. We are increasingly aware that post-transcriptional regulation of gene expression shapes the sensitivity and plasticity of nociceptive sensory neurons and nociceptive behavior. In Drosophila, the Pumilio RNA-binding protein interacts with diverse target mRNAs to regulate their abundance and translation in a wide range of contexts including the establishment of …

Senescent Fibroblasts In Aging And Pulmonary Fibrosis, Sara B. Palega, Aiwei Y. Borengasser, Yan Y. Sanders

Microbiology & Molecular Cell Biology Faculty Publications

Aging is a major risk factor for many chronic lung diseases, including Idiopathic Pulmonary Fibrosis (IPF), a fatal and incurable disease characterized by progressive fibrotic remodeling. Age-associated structural alterations, impaired regenerative capacity, and dysregulated cellular signaling collectively create a pro-fibrotic microenvironment. A central driver of this pathological shift is the accumulation of senescent cells, which undergo irreversible growth arrest and develop a robust pro-inflammatory senescence-associated secretory phenotype (SASP). Emerging evidence identifies senescent lung fibroblasts as critical mediators of IPF pathogenesis. These cells promote excessive extracellular matrix deposition, myofibroblast differentiation, and tissue stiffening, while simultaneously impairing epithelial regeneration. Together, these effects …

Single-Cell Transciptomic Analysis Reveals Age-Related Remodeling Of Brain Endothelial Cells, Hai Duc Nguyen, Summer Siddiqui, Diana G. Bohannon, Robert V. Blair, Hong-Wen Deng, Alexandre Prat, Woong-Ki Kim

Microbiology & Molecular Cell Biology Faculty Publications

Blood–brain barrier (BBB) integrity naturally declines with age. Brain endothelial cells (ECs) and pericytes (PCs) form the BBB, and aging impairs tight junctions, likely via altered PC-to-EC signaling. However, the molecular mechanisms underlying this impairment remain unclear. Using single-cell RNA sequencing, we profiled 68,316 brain ECs expressing 15,564 genes from young and old mice. Unsupervised clustering and annotation revealed five distinct EC subtypes—Capillary EC1, Capillary EC2, Arterial EC, Venous EC1, and Venous EC2—defined by marker genes Mfsd2a, Plvap, Bmx, Nr2f2, and Vcam1, respectively. Aging shifted EC subtype distribution, with reduced Capillary EC1 (45% vs. 57%) and increased Arterial …

Llm-Assisted Legal Propositions Identification From Party Arguments In The U.S. Supreme Court Briefs, Heng Zheng, Alex Zhang

Faculty Scholarship

Merits briefs are central to U.S. litigation, serving as the primary means for parties to present arguments and persuade judges. Legal propositions in these merits briefs are the atomic units of arguments, whose relationships evolve throughout litigation and inform court decisions and precedent. Large language models (LLMs) have been applied to legal document review, but there is limited evidence on their ability to identify legal propositions in merits briefs. Given the laborintensive nature of the task, we evaluate a human-AI collaborative approach to identifying legal propositions in the U.S. Supreme Court merits briefs, in which legal annotators review and revise …

Places My Anxiety Lives, Sydney Dombrowik

OTD 721: Cultural Responsiveness & Occupation

Through sharing my story, I hope to increase awareness of how anxiety can influence everyday life and remind others that they are not alone in their mental health journey. The pages in this zine highlight the different environments where my anxiety is most present.

My own experiences have shown me that mental health can have a significant impact on health outcomes, routines, and wellbeing. As a future occupational therapist, I will strive to consider each client's mental health experiences and perspectives when providing client-centered care.

Braided Thoughts: Beautifully Indigenous, Trinity Gould

OTD 721: Cultural Responsiveness & Occupation

I am an enrolled tribal member of the Spokane Tribe, and I have cultural ties to the surrounding tribes as well. I have a daughter who is currently a first line descendent of my tribe through me, and I want to tell my daughter the importance of our shared culture.

I want to show her through this zine a snippet of our culture traditions and practices to educate her that our culture is still here and we should be proud of who we are and our culture. I want her to uphold our traditions to carry on to the next …

The Culture Of Fast Fashion, Karli Reed

OTD 721: Cultural Responsiveness & Occupation

As a current Whitworth OTD student, I reacted this zine to educate fellow students and young adults about the impacts of fast fashion. Social media often pressures us to keep up with trends and fit a certain mold, but finding your own voice and style is far more meaningful. Exploring fashion in a more person- and environmentally-friendly way -- such as thrifting, repairing clothing, or investing in quality pieces form ethical brands -- can help reduce many of the issues highlighted in this zine.

As future practitioners/members of society, we can also share these ideas with our clients and peers. …

"Mangia, You're Too Skinny": A Story Of Italian Culture, Theresa Oliveri-Montes

OTD 721: Cultural Responsiveness & Occupation

"Mangia, You're Too Skinny": A Story of Italian Culture is a personal reflection of my Italian heritage. With this zine, I sought to not only explain, but illustrate, pieces of Italian culture and traditions. Each photograph includes members of my family and our food that we prepare.

My family immigrated to the United States from San Giovanni in Fiore, which is a small village in Calabria, located in southern Italy. They did not experience the "American Dream" that is portrayed in the media. Instead, they grappled with fear, prejudice, and the pressure to assimilate, which resulted in the loss of …

Rooted: Nature, Belonging, & Occupational Justice, Grace Barnett

OTD 721: Cultural Responsiveness & Occupation

This zine was created for OTD 721: Cultural Responsiveness & Occupation. I recognize that I cannot speak or represent all cultures, but I approach this work with cultural curiosity and a commitment to learning. I was intentional about not speaking for others, but instead reflecting on my own understanding, experiences, and using scholarly articles.

I chose this topic because environments have a powerful influence on occupational participation. Nature, in particular, has been a source of healing, grounding, and comfort in my own life, which shaped my interest in exploring this connection more deeply though an occupational lens.

One of the …

Occupations Around The World: What Other Cultures Have Taught Me, Elliot Hammond

OTD 721: Cultural Responsiveness & Occupation

This zine is meant to highlight the wisdom that other cultures, people, and experiences have brought into my life. Culture and place deeply shape who we are; stepping into other cultures often challenges us in new and profound ways as people. It tests our beliefs and begs us to question our ways of living.

My advice is this: get out of your world; step into someone else's. Ask good questions, remain humble in your understanding, and be open to learning.

How To Be 2slgbtqia+ And Neurodivergent Affirming As An Occupational Therapist, Ellie Shoop

OTD 721: Cultural Responsiveness & Occupation

When we were asked at the beginning of our class, "What is one thing you have experienced that you wish no one would ever have to experience again?", by author and occupational therapist Elizabeth Ching, OTD, M.Ed., BSOT, OTR/L, my mind began to swirl with ideas. I identify as a gay, white, neurodivergent, non-binary person, and I wish that no one would be misgendered or have their sexuality assumed by health professionals ever again. I also wish that people with neurodivergent brains would be given the support they need to thrive in a world that was not built with us …

Looking Out, Looking In: Air Travel, Culture, & Occupational Justice, Ashley Compton

OTD 721: Cultural Responsiveness & Occupation

As I continue becoming an occupational therapist, I've found myself caring more deeply about accessibility, inclusion, and the different ways people experience participation in meaningful occupations. This zine gave me the opportunity to think about travel as a meaningful occupation that can be shaped by culture, identity, privilege, accessibility, and opportunity.

Travel, particularly air travel, has shaped so much of who I am, and creating this zine helped me think more deeply about what it means to participate in the world. My hope is that it encourages others to think about who may be left out and how we can …

What If I Fail...?, Benjamin Janke

OTD 721: Cultural Responsiveness & Occupation

The theme of "fear of failure" is a unique field in occupational therapy because of the power it has to completely inhibit or affirm occupational participation. Fear of failure is something that has been a struggle in my past and is still part of my life that I'm trying to work on as a person and as an aspiring occupational therapy practitioner.

Even though failing is difficult and sometimes painful, it's amazing to see what rises in its place with time. Because of how unique our fears and perceptions about failure are, we must utilize cultural humility and holistic care …

Girl, Just Shut Up & Take An Advil: A Zine About Periods, Participation, And Why We All Became Experts At The Tampon-To-Sleeve Transfer, Alexa Ford

OTD 721: Cultural Responsiveness & Occupation

Like many people, I learned early on that menstruation was something to manage quietly. I learned how to check for stains without making it obvious. I learned how to strategically tie a sweatshirt around my waist. I learned that asking, "Do you have one?" across a public restroom often resullts in an immediate and enthusiastic, "Yes, girl. What do you need?" Over time, I realized these weren't just funny shared experiences. They reflected something bigger. The silence. The stigma. The expectation that people should function through discomfort without complaint.

As I've learned more through occupational therapy, I've started to understand …

Finding My Voice In The City Of Destiny: Music, Identity, And Occupational Justice In Tacoma's Creative Culture, Bella Holtz

OTD 721: Cultural Responsiveness & Occupation

Tacoma's music culture taught me that participation is more than simply doing an activity. Through music, I found identity, belonging, and a deeper understanding of community. As a future occupational therapist, I hope others access meaningful occupations that allow them to discover their own voice.

The Stories That Shape Us, Brenna Strand

OTD 721: Cultural Responsiveness & Occupation

Reading has always been a meaningful occupation in my life. Some of my earliest memories involve my family gathering around stories, reading a chapter of Harry Potter or Percy Jackson before bed, or sharing stories around a campfire. These rituals shaped my sense of connection, imagination, and belonging. However, when I entered school and began struggling to read independently, I felt a growing disconnect from the culture and routines that had once grounded me. That experience made me aware of how deeply reading influences identity, confidence, and participation in everyday life.

This zine explores reading through an occupational therapy lens, …

Stitched With Purpose, Abigail Gooler

OTD 721: Cultural Responsiveness & Occupation

I chose this topic for this zine because fiber arts have become a meaningful part of my life. What began as a hobby during the COVID pandemic has grown into a way for me to manage stress, find purpose through creating, and build a small business.

This project deepened my understanding of occupational justice and the way that occupations are shaped by culture, gender, access, and social determinants of health. It challenged me to view what is an everyday occupation for me as culturally significant and, at times, political.

This project also reminded me of the privilege I have to …

The Interplay Between Loneliness, Cortisol, And Nk Cell Function: The Role Of Cortisol In Nk Cell Dysfunction, Abhinav Saurabh, Yvonne Baumer, Laurel G. Mendelsohn, Elizabeth M. Aquino Peterson, Dana Sadler, Shirley J. Lopez De Leon, Ayushi Dave, Andrew S. Baez, Lola R. Ortiz-Whittingham, Mario A. Pita, Manuel A. Cintron, Hannatu A. Tarfa, Sandy T. Reynolds, Shelby R. Hicks, Sonal Sharda, J. Eleanor Seo, Maria Lopez-Ocasio, Pradeep K. Dagur, Skyler A. Kuhn, Neelam R. Redekar, James F. Troendle, Ayanna L. Wells, Marie Marah, Katherine J. Tolentino, Michael J. Corley, Alika K. Maunakea, Lynnette K. Nieman, Marcus R. Andrews, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

Chronic psychosocial stressors contribute to cardiovascular disease (CVD) and related risk factors, particularly in under-resourced communities. Psychosocial stressors activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to sustained cortisol action on immune cells. Natural killer (NK) cells are altered in distribution and function in cardio-metabolic diseases; however, pathways linking cortisol as a marker of chronic stress to NK cell dysfunction remain understudied. We recruited 186 African American women from the Step It Up Community-Engaged, Digital Health Physical Activity Intervention study and collected cortisol, NK cell measures, and psychosocial stress measures using validated questionnaires, including chronic stress and loneliness. Plasma cortisol levels were …

The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

Substance use disorders (SUDs) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (ROS) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused substances including alcohol, cocaine, …

Quadriceps And Ankle Weakness In Inclusion Body Myositis: Impact On Descending Balance Control And Rehabilitation Strategies - A Systematic Review, Woohyoung Jeon, Ashley Dalby, Melinda Hermanns, Manuel Lubinus

Nursing Faculty Publications and Presentations

Background

Inclusion Body Myositis (IBM), a progressive neuromuscular disorder, is characterized by quadriceps and ankle muscle weakness, leading to impaired balance control and increased fall risk during functional activities. Existing research highlights inconsistent evidence on fall risk reduction and a lack of standardized rehabilitation protocols, creating gaps in effective management. This systematic review aims to synthesize evidence on the impact of muscle weakness on balance and fall risk and evaluate rehabilitation strategies, including task-specific interventions, to improve functional outcomes in IBM patients.

Methods

Following PRISMA guidelines, we conducted a systematic search of MEDLINE, Embase, and the Cochrane Library from inception …

Optimal Quantization On Spherical Surfaces: Continuous And Discrete Models—A Beginner-Friendly Expository Study, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

This expository paper provides a unified and pedagogical introduction to optimal quantization for probability measures supported on spherical curves and discrete subsets ofthe sphere, emphasizing both continuous and discrete settings. We first present a detailedgeometric and analytical foundation for intrinsic quantization on the unit sphere, includingdefinitions of great and small circles, spherical triangles, geodesic distance, Slerp interpolation,the Fréchet mean, spherical Voronoi regions, centroid conditions, and quantizationdimensions. Building upon this framework, we develop explicit continuous and discretequantization models on spherical curves, namely great circles, small circles, and greatcircular arcs—supported by rigorous derivations and pedagogical exposition. For uniformcontinuous distributions, we compute optimal …

Gain-Delay Decoupling In Human Stimulus Frequency Otoacoustic Emissions Reveals Constraints On Cochlear Nonlinear Amplification, Yoshita Sharma, Arturo Moleti, Renata Sisto, Teresa Botti, Hansapani Rodrigo, Sri Mishra

School of Mathematical & Statistical Sciences Faculty Publications

Purpose: The nonlinear cochlear amplifier, driven by outer hair cells, underlies the remarkable sensitivity and frequency selectivity of the mammalian auditory system. Stimulus frequency otoacoustic emissions (SFOAEs) provide a noninvasive window into these active cochlear processes, yet the relationship between emission gain and delay across stimulus levels remains incompletely understood. This study examined the level dependence of SFOAEs in normal-hearing human listeners to characterize cochlear nonlinear response properties. We tested how emission gain and delay vary with stimulus level and estimated the frequency of the apical–basal transition associated with the breakdown of the approximate local scaling symmetry.

Methods: SFOAEs were …

Pedagogical Moves For Provoking Prospective Teachers’ Intellectual Needs While Connecting Abstract Algebra And Secondary Mathematics, Kaitlyn Stephens Serbin, Estrella Johnson, Sthefanía Espinosa

School of Mathematical & Statistical Sciences Faculty Publications

Researchers have exhibited ways in which prospective secondary mathematics teachers can connect content from abstract algebra with secondary mathematics in ways that reshape their understanding of secondary mathematics and thereby support their teaching of that content. However, there has been very little research done on what mathematics teacher educators can do in the classroom to help prospective teachers make connections between abstract algebra and secondary algebra in ways that support such reshaping. This study focuses on a mathematics teacher educator who guided a class of prospective teachers to connect properties of algebraic structures with equation-solving procedures by directing their focus …

Fully Discrete Finite Element Methods For The Stochastic Kuramoto–Sivashinsky Equation With Multiplicative Noise, Hung D. Nguyen, Liet Vo

School of Mathematical & Statistical Sciences Faculty Publications

We investigate a fully discrete finite element approximation for the stochastic Kuramoto–Sivashinsky equation, combining the standard finite element methods in spatial discretization with the implicit Euler–Maruyama scheme in time. Rigorous error estimates are established for two distinct noise regimes. In the case of bounded multiplicative noise, we prove optimal strong convergence rates in full expectation. The analysis relies crucially on a stochastic Gronwall inequality and an exponential stability estimate for the PDE solution, which together control the interplay between the nonlinear drift and the multiplicative stochastic forcing. For general multiplicative noise, where boundedness no longer holds, we derive sub-optimal convergence …

Coaching For Emotional Resilience And Reflective Growth: Applying The University-Based Coaching Framework In Pre-Service Teacher Supervision, Dana L. Morris

Education Faculty Publications and Presentations

Teacher preparation is an emotional as well as a cognitive process in which pre-service teachers must develop both reflective judgment and the emotional resilience needed for demanding instructional contexts. This study examined how university-based supervisors enacted the relational spaces of the University-Based Coaching Framework (UBCF) and how these enactments shaped pre-service teachers’ emotional and reflective development. Drawing on qualitative analysis of coaching discourse among three supervisor-preservice teacher pairs, the comparative case study identifies distinct coaching identities that emerged from supervisors’ patterned relational moves. These identities corresponded to varying intensities of UBCF space enactment and produced differential pathways through a reflective-motional …