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Serum Igg N-Glycosylation Profiles Distinguish Primary Sjögren’S Disease, Rheumatoid Arthritis, And Systemic Lupus Erythematosus And Are Associated With Disease Activity In Sjögren’S Disease, Zhixian Chen, Xiaojia Xu, Manshu Song, Fengcai Shen, Haifeng Hou, Wei Wang, Ling Lin

Research outputs 2022 to 2026

Background: IgG N-glycosylation regulates immune effector functions and inflammation, but disease-specific patterns in primary Sjögren’s disease (SjD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are insufficiently defined, particularly in SjD.

Objectives: To identify serum IgG N-glycan biomarkers that differentiate SjD, RA, and SLE and reflect disease activity in SjD.

Design: A clinical case-control study.

Methods: Serum IgG N-glycans from 88 SjD patients, 102 RA patients, 86 SLE patients and 91 healthy controls were profiled using ultra-performance liquid chromatography. Discriminative glycans were selected through machine learning-based feature selection and evaluated for their diagnostic performance using cross-validated logistic regression and receiver …

Sarcopenia, Obesity, Sarcopenic Obesity And Dementia Risk: A Systematic Review And Meta-Analysis Of Cohort Studies, Uraiporn Booranasuksakul, Zhongyang Guan, Leticia Radin Pereira, Kostas Tsintzas, Ian Macdonald, Ellise Stirling, Sana Farzam, Lorenzo M. Donini, Alexandra M. Johnstone, Marc Sim, Blossom Stephan, Mario Siervo

Research outputs 2022 to 2026

Sarcopenia and obesity, characterised respectively by reduced muscle mass and function and increased adiposity, may co-occur as sarcopenic obesity (SO). This systematic review summarises cohort evidence linking these body composition phenotypes to dementia risk. MEDLINE, EMBASE, Cochrane Database and PsycINFO were searched from inception to February 2026. Outcomes included incident all-cause dementia (ACD) and subtypes. Pooled hazard ratios were calculated for each phenotype using random-effects models. Fourteen publications were included for sarcopenia, 72 for obesity, and four for SO. Late-life obesity (≥65 years) was protective for ACD (HR 0.83, 95% CI 0.76–0.89), whereas mid-life obesity (<65 years) modestly increased risk (HR 1.09, 95% CI 1.01–1.16). Sarcopenia was associated with increased risk (HR 1.42, 95% CI 1.26–1.58). SO showed no significant association (HR 1.43, 95% CI 0.87–1.99). These findings highlight age-dependent effects of obesity and an elevated dementia risk with sarcopenia; the predictive role of SO requires further research.

Effect Of Blood Flow Restricted Walking On Cardiovascular Fitness, Muscular Development, And Functional Performance In Adults: A Systematic Review With Meta-Analysis, Michael Beere, James R. Mckee, Isaac Selva Raj, Kieran J. Marston, Kristen De Marco, Brook Galna, Jeremiah J. Peiffer, Belinda Brown, Keith D. Hill, Peter Edwards, Brendan R. Scott

Research outputs 2022 to 2026

Increasing evidence from randomised controlled trials demonstrates blood flow restriction (BFR) improves walking intervention outcomes compared to walking without BFR. This systematic review and meta-analysis examined the effects of BFR walking interventions on cardiovascular fitness, muscle strength and hypertrophy, and functional performance in adults, and moderators of age, health status, training volume and intensity. Six databases were systematically searched following PRISMA guidelines, up to April 2025. Studies were eligible if participants were ≥ 18 years, included randomised controlled trials with BFR walking interventions ≥ 12 sessions and ≥10 min/session, at least one measure of cardiovascular fitness, muscular strength, muscular hypertrophy, …

Evaluation Of Poly-Ε-Caprolactone/Graphene Oxide Three-Dimensional Porous Scaffolds For Potential Application In Alveolar Bone Repair, Yung-Kang Shen, Huei-Yu Huang, Jowy Tani, Hsuan Chen, Silvia Anitasari, Hendrik Budi, Wei-Chun Lin

Journal of Dental Sciences

Background/purpose Alveolar bone reconstruction or regeneration demands the interim porous scaffold. It possesses adequate mechanical properties to enable it to withstand injured bones. These scaffolds are used to regulate the cell growth that migrate from surrounding tissue or are implanted within porous scaffold. This study is devoted to the manufacturing of 3D porous scaffolds and application on repair and regeneration of alveolar bone. Materials and methods Graphene oxide (GO) was mixed with poly-ε-caprolactone (PCL) material to fabricate 3D porous scaffolds by a solvent-casting/particulate-leaching method. The effects of various concentrations of GO (0.05, 0.1, 0.5, 1, and 2 wt.%) in PCL/GO …

Biofunctionalized 3d-Printed Gelatin-Alginate Scaffolds With Arginine-Glycine-Aspartic Acid (Rgd) Peptides For Enhanced In Vitro Osteogenesis, Ting-Yi Renn, You-Ru Ma, Chia-Chen Hsu, Eisner Salamanca, Hiroshi Egusa, Ying-Sui Sun, Chun-Pin Lin, Wei-Jen Chang

Journal of Dental Sciences

Background/purpose Alveolar bone defects are difficult to treat due to ongoing resorption and limitations of conventional grafts. Tissue engineering strategies, particularly 3D hydrogel-based scaffolds, offer promising alternatives by mimicking the extracellular matrix and supporting cell-driven regeneration. This study aimed to incorporating arginine-glycine-aspartic acid (RGD) peptides into 3D-printed gelatin-alginate hydrogels to enhances their bioactivity and osteogenic potential for effective alveolar bone repair. Materials and methods The physical characterization of RGD peptides-grafted 3D-printed gelatin-alginate scaffolds was conducted using morphological observation, elemental composition analysis, Fourier-transform infrared spectroscopy (FTIR), and assessments of swelling and degradation behavior. Biological performance was examined in vitro through cell …

Human Oral Microbiota Dysbiosis May Be A Novel Non-Invasive Indicator Of Erectile Dysfunction, Yu Qiao, Fei Mao, Bing-Ru Jiang, Shu-Yan Lv, Heng-Bing Wang, Guang-Bo Fu

Journal of Dental Sciences

No abstract provided.

Risk Of Deep Vein Thrombosis In Patients With Periodontitis: A Nationwide Population-Based Cohort Study In Taiwan, Ying-Ting Yeh, Nai-Chen Shih, Ping-Ju Chen, Yu-Hsun Wang, Chao-Bin Yeh

Journal of Dental Sciences

No abstract provided.

Developing Anti-Inflammatory Mineral Trioxide Aggregate As Dental Implant Crown Cement To Reduce Peri-Implantitis Incidence, Yung-Fu Hsu, Sea-Fue Wang, Yi-Le Liao, Chih-Sheng Lin, Ssu-Chi Chen, Sheng-Yang Lee, Wei-Chun Lin

Journal of Dental Sciences

背景/目的：牙周組織周圍的牙科樹脂黏固劑殘留是植體周圍炎的原因之一。嚴重病例可能導致植體鬆動或脫落。因此，本研究旨在對礦物三氧化物聚集體（MTA）進行改性，使其成為一種抗發炎的牙科植體冠黏固劑（ICC）。

材料與方法：本研究評估了去離子水溶液（Daq）、羥基磷灰石溶液（Haq）和氯化鈣溶液（Caq）對ICC凝固時間、抗壓強度、黏結強度和生物相容性的影響。以單因子變異數分析（ANOVA）檢定各實驗組間的差異（ P < 0.05）。

結果：表面微觀結構分析表明，添加Haq和Caq有助於ICC顆粒間的結合。表面元素分析表明，添加Haq增加了Ca離子含量。凝固時間結果表明，與Daq相比，Caq和Haq分別使最終凝固時間縮短了46.5%和34.7%（ P < 0.05）。 Caq的抗壓強度分別比Daq和Haq高35.1%和13.4%（ P < 0.05）。三種ICC組的黏接強度結果表明，樹脂黏接劑的效果相同（ P > 0.05）。生物相容性和清除活性測試表明，ICC優於樹脂黏接劑。

結論： ICC與Caq合併使用可縮短凝固時間、提高抗壓強度、增強生物相容性並降低發炎發生的可能性。因此，ICC與Caq聯合使用可作為牙科樹脂黏固劑的替代方案。

Optical Properties Of Conventional And High-Translucency Zirconia Ceramics And Their Effects On Resin Cement Polymerization, Chia-Ling Li, Ping-Ju Chen, Jui-Che Lin, Shu-Fen Chuang

Journal of Dental Sciences

Background/purpose: Adequate polymerization of resin luting cements is essential for durable bonding in zirconia restorations. However, variations in zirconia microstructure and composition may influence translucency and light transmittance, thereby affecting resin cement polymerization. This study aimed to investigate the optical properties of conventional and high-translucency zirconia ceramics and their effects on resin cement polymerization.

Materials and methods: Six zirconia ceramics were evaluated: CerconBase, CerconHT, and VitaHT (3Y-TZP); VitaST (4Y-PSZ); and CerconXT and VitaXT (5Y-PSZ). Disk specimens (0.5 and 1.0 mm thick) were fabricated and sintered. Grain size and elemental compositions were analyzed using scanning electron microscopy and energy-dispersive X-ray …

Modulation Of Osteoclast Differentiation By Epigallocatechin-3-Gallate (Egcg)/Type I Collagen–Coated Titanium Implant Surface In Vitro, Her-Hsiung Huang, Yu-Ying Cheng, Chia-Fei Liu, Wei-Cheng Chen

Journal of Dental Sciences

Background/purpose: Implant osseointegration depends not only on osteogenesis but also on coordinated bone remodeling. Our previous study demonstrated that epigallocatechin-3-gallate (EGCG)/type I collagen–coated titanium (Ti) surfaces enhance angiogenesis and osteogenic differentiation in vitro. However, their influence on osteoclast differentiation remains unclear. This study evaluated the modulatory effects of this coating on osteoclast responses in vitro.

Materials and methods: Sandblasted and acid-etched (SLA) Ti surfaces followed by alkaline treatment (SLAA) were prepared. Type I collagen was immobilized onto SLAA surfaces using the natural crosslinker EGCG (10 or 50 μg/mL). Surface morphology, roughness, hydrophilicity, and functional groups were characterized. RAW 264.7 macrophages …

Pathogenic Oral Microbiota Abundance Is Associated With Reduced Bite Force In Patients With Periodontitis, Chih-Chieh Wen, Thu Ya Linn, Ting-Yi Renn, Hui Yin Nam, Chia-Chen Hsu, Yi-Jen Lin, Yi-Fan Wu, Wei-Jen Chang

Journal of Dental Sciences

Background/purpose: Periodontitis leads to tissue destruction and functional impairment, but the interplay between microbiota, clinical parameters, and biomechanics remains unclear. This study aimed to quantitatively correlate specific oral microbial signatures and clinical inflammatory indicators with bite force in patients with periodontitis.

Materials and methods: Fifteen patients with stage III-IV periodontitis and 15 periodontally healthy controls were recruited. Clinical parameters (Probing Depth, Clinical Attachment Loss, Bleeding on Probing, Plaque Index) and MBF (pressure-sensitive film) were recorded. Supragingival plaque was analyzed through 16S rRNA gene sequencing (PacBio SMRT) to determine microbial composition. Correlation analyses were performed.   

Results: The periodontitis …

Rigorous Validation Of Machine Learning Models For Orthodontic Extraction Prediction Using Nested Cross-Validation And Smotenc-Integrated Pipelines., Anh Thi-Ngoc Do, Hung Trong Hoang, Thuy-Trang Thi Ho, Hieu Ngoc Le

Journal of Dental Sciences

Background/purpose: Machine learning (ML) in orthodontics often suffers from optimistic bias due to data leakage and improper handling of class imbalance. This study implemented and evaluated a production-grade validation framework - nested cross-validation (CV) - for three distinct algorithm classes (logistic regression, random forest, and gradient boosting) using a consensus-labeled orthodontic dataset.

Materials and methods: A retrospective dataset of 500 patients (334 non-extraction/166 extraction) was curated with 41 processed features. Two stratified split protocols (70/30 and 80/20) were evaluated to assess model robustness. To ensure methodological rigor, a 5-fold outer/3-fold inner nested cross-validation was implemented. Crucially, SMOTENC (synthetic minority over-sampling …

Influence Of All-On-4 Implant Angles On Stability And Crestal Bone - A Finite Element Optimization Analysis,, Jing-Jie Chen, Chen-Sheng Chen

Journal of Dental Sciences

No abstract provided.

Poly-Ε-Caprolactone/Multi-Wall Carbon Nanotube Composites As Osteoinductive Scaffolds For Alveolar Bone Regeneration,, Chien-Yang Yeh, Firdiansyah Rasyid

Journal of Dental Sciences

No abstract provided.

Comparative Effects Of Plasma Activation And Monomer Infiltration On The Surface Characteristics And Wettability Of 3d-Printed Permanent Crown Resin,, Pyi Phyo Win, Szu-Yu Lai

Journal of Dental Sciences

No abstract provided.

Activities Of Dental Hygienists Registered In The Disaster Relief System Of The Japan Dental Hygienists’ Association In The 2024 Noto Peninsula Earthquake, Hitomi Suzuki, Kumiko Sugimoto

Journal of Dental Sciences

No abstract provided.

Mesenchymal Stem Cells Derived From Gingiva Normoxic Or Hypoxic-Preconditioning Allogenous Transplantation Affect Orthodontic Tooth Movement In Vivo, Alexander Patera Nugraha, Guang Hong

Journal of Dental Sciences

No abstract provided.

Strategy Of Allying General Dentistry Staffs Into Pre-Anesthetic Dental Assessment Reduces Perioperative Dental Injury Risk During General Anesthesia, Cheng Lu, Mei-Chun Chen

Journal of Dental Sciences

No abstract provided.

Oral Health-Related Quality Of Life And Diabetes Outcomes: Evidence From A Nationally Representative U.S. Sample, Hsueh-Fen Chen, Jou-Hsun Lee

Journal of Dental Sciences

No abstract provided.

Vanadium-Functionalized Methyl Methacrylate-Based Primer Enhances Self-Curing And Bonding Of Resin Cement To Polyetheretherketone Restorations, Takeru Kondo, Jun Sato

Journal of Dental Sciences

No abstract provided.

Comparative In Vivo Study Of 3d-Printed Composite Bioceramic Scaffolds Fabricated By Distinct Pre-Processing Methods, Yu-Ting Li, Ju-Hsuan Yang

Journal of Dental Sciences

No abstract provided.

Retrospective Accuracy Comparison Of Marker-Based And Marker-Free Registrations Using Dynamic Implant Navigation, Zhiyi Zhu, Shikai Zhao

Journal of Dental Sciences

No abstract provided.

Postoperative Conductive Hearing Loss After Full-Arch-Implantation Surgery Under General Anesthesia In An Oral Submucous Fibrosis Patient: A Case Report, Hao-Chen Wang, Fu-Chuan Tsai, Chia-Che Wu, Chih-Yuan Fang

Journal of Dental Sciences

No abstract provided.

Factors Influencing Dental Career Decision-Making Among High-Achieving Students In Taiwan, Chien-Hong Yu, Mei-Huei Li, Feng-Chou Cheng, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Effects Of Cleaning Protocols On The Material Properties Of Clear Aligners And Retainers: A Systematic Review, Yao-Chang Chiang, Tu Manh Nguyen, Thuy-Trang Thi Ho, Loc Minh Lu, Yang-Che Wu, Tong-Hsien Chow, Chiang-Wen Lee, Fang-Yu Fan, Li-Nai Chen, I-Ta Lee

Journal of Dental Sciences

Clear aligners and retainers are widely used in contemporary orthodontics because of their esthetic appearance, removability, and patient-centered advantages. However, repeated exposure to dietary pigments and cleaning procedures may alter their optical, surface, mechanical, and chemical properties, potentially affecting appliance appearance, hygiene, and performance. This systematic review evaluated changes in the material properties of clear aligners and retainers following different cleaning protocols. Electronic searches were performed in PubMed, Scopus, LILACS, and the Cochrane Library from inception to February 28, 2026. Twenty studies were included, comprising 18 in vitro studies and 2 randomized clinical crossover studies. Cleaning protocols were categorized as …

Herbal Medicine For Oral Ulcer Treatment: Mechanisms, Efficacy, And Therapeutic Potential, Shinn-Zong Lin, Tsung-Hsien Chuang, Chih-Yang Huang, Tsung-Jung Ho, Yi-Pang Lee

Journal of Dental Sciences

Oral ulcers are common inflammatory lesions of the oral mucosa that significantly affect patients’ quality of life through pain, eating difficulties, and psychological stress. Their development is multifactorial, involving mechanical trauma, infection, nutritional deficiencies, immune dysregulation, and oxidative stress. Conventional treatments including antiseptics, corticosteroids, and immunomodulators, provide symptomatic relief but are often limited by side effects, recurrence, and poor patient adherence. Increasing interest has therefore focused on herbal medicines as complementary or alternative therapies. Numerous single herbs such as Aloe vera, licorice, curcumin, chamomile, berberine, neem, sage, myrrh, and guava and traditional formulations have demonstrated anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and …

The Ph-Pi3k/Akt/Mtorc1 Axis In The Survival Of Stem Cells From The Apical Papilla: A Critical Target For Rescue By Microenvironment-Engineered Hydrogels In Pulp Regeneration, Chunlei Zhang, Haisheng Cao, Jie Li, Changqing Yan, Yang Liu, Shuguo Zheng, Xiaozhe Wang

Journal of Dental Sciences

Background/purpose: The pH within infected root canals fluctuates dynamically under pathological conditions, yet its impact on stem cells from the apical papilla (SCAPs) in dental pulp regeneration remains unclear. This study investigated how potential of hydrogen (pH) variations govern SCAPs survival and the associated signaling to identify therapeutic targets for enhancing tissue regeneration.

Materials and methods: SCAPs were cultured at pH 5.4-10.4. Proliferation and apoptosis were assessed using cell counting kit-8 (CCK-8) assays, real-time live-cell analysis, and flow cytometry. RNA-sequencing (RNA-seq) identified differentially expressed genes, which were validated through reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR), Western blotting, and mechanistic …

Osteoblastogenesis Stimulation By Human Umbilical Cord Stem Cell Secretome During Maxillary Expansion, Alexander Patera Nugraha, Guang Hong, Firdaus Hariri, I Gusti Aju Wahju Ardani, Adya Pramusita, Nurul Aisyah Rizky Putranti, Nindya Rizky Anjani Marhendra, Naora Dewi Rahma Fadzila, Ananda Firman Putranto, Muhammad Luthfi, Wibi Riawan, Putri Cahaya Situmorang, Rony Abdi Syahputra, Thantrira Porntaveetus, Khairul Anuar Shariff, Nissia Ananda, Maudina Dwi Heriasti, Kotaro Tanimoto

Journal of Dental Sciences

Background/purpose: Maxillary expansion induced by mechanical force (MEMF) is a standard orthodontic approach for correcting transverse maxillary deficiency. The human umbilical cord mesenchymal stem cell secretome (HUCMSC-S) has the potential to stimulate accelerate bone remodeling. This study aimed to evaluate local HUCMSC-S application effect during MEMF on the expression bone morphogenetic protein (BMP)-2, BMP-4, BMP-7, vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), transforming growth factor-beta (TGF-β), and fibroblast growth factor-2 (FGF-2) in a Wistar rat (Rattus norvegicus).

Materials and methods: Twenty-four healthy male Wistar rats (R. norvegicus) were randomly divided into four groups: …

A Bibliometric Evolution Of Molecular Mechanisms And Emerging Research Trends Of Therapeutic Resistance In Oral Cancer, Chu-Yen Chien, Ying-Chen Chen, Jia-Rong Wu, Hsu-Hua Chu, Yi-Jen Hung, Yi-Shing Shieh

Journal of Dental Sciences

Background/purpose: Drug resistance has served as a primary determinant of treatment failure and disease recurrence in oral cancer. The present study aimed to evaluate the global research landscape of drug resistance mechanisms in oral cancer by integrating bibliometric mapping with bioinformatic validation.

Materials and methods: A comprehensive dataset of 1660 publications was retrieved from the Scopus database. Bibliometric analyses were performed using Biblioshiny and VOSviewer to evaluate publication trends, collaborative networks, and thematic evolution. To bridge research trends with biological mechanisms, 1469 genes associated with oral cancer and drug resistance were extracted from the GeneCards database and subjected to functional …

Adhesion Performance Of Conventional And High-Translucency Zirconia: Effects Of Airborne-Particle Abrasion And 10-Methacryloyloxydecyl Dihydrogen Phosphate Treatments, Chia-Ling Li, Li-Li Kang, Jui-Che Lin, Shu-Fen Chuang

Journal of Dental Sciences

Background/purpose: High-translucency zirconia exhibits different microstructure and composition, which may influence their responses to mechanical and chemical treatments, affecting resin–zirconia adhesion. This study aimed to evaluate the adhesive behaviors of conventional and high-translucency zirconia, focusing on surface modifications induced by airborne-particle abrasion (AA) and 10-methacryloyloxydecyl dihydrogen phosphate (MDP).

Materials and methods: Disk-shaped specimens were fabricated from six zirconia materials: CerconBase, CerconHT, and VitaHT (3Y-TZP); VitaST (4Y-PSZ); and CerconXT and VitaXT (5Y-PSZ). Specimens were air-abraded with alumina particles at 0.25 MPa. Micromorphology and roughness were analyzed using scanning electron microscopy (SEM), profilometry, and atomic force microscopy (AFM). Surface chemical composition …