Digital Commons Network^™

Senolytic-Resistant Senescent Cells Have A Distinct Sasp Profile And Functional Impact: The Path To Developing Senosensitizers, Bryan T Piatkowski, Allyson K Palmer, Nino Giorgadze, Christina Inman, Nathan Gasek, Ming Xu, Kurt O Johnson, Tamar Pirtskhalava, Selim Chaib, Larissa P G Langhi Prata, Yi Zhu, Renuka Kandhaya-Pillai, Stefan G Tullius, Saranya P Wyles, Rambabu Majji, Hari Krishna Yalamanchili, David B Allison, Tamar Tchkonia, James L Kirkland

Faculty, Staff and Students Publications

The senescent cell (SC) fate is linked to aging, multiple disorders and diseases, and physical dysfunction. Senolytics, agents that selectively eliminate 30%-70% of SCs, act by transiently disabling the senescent cell antiapoptotic pathways (SCAPs), which defend those SCs that are proapoptotic and pro-inflammatory from their own senescence-associated secretory phenotype (SASP). Consistent with this, a JAK/STAT inhibitor, Ruxolitinib, which attenuates the pro-inflammatory SASP of senescent human preadipocytes, caused them to become "senolytic-resistant". Administering senolytics to obese mice selectively decreased the abundance of the subset of SCs that is pro-inflammatory. In cell cultures, the 30%-70% of human senescent preadipocytes or human umbilical …

Organ Chips And Translational Research: Identifying And Examining New Ethical Issues, Melanie Jeske

Center for Medical Ethics and Health Policy Staff Publications

Organ chips, also known as organ-on-a-chip devices, tissue chips, or microphysiological systems, have emerged over the last decade as a promising translational technology amidst growing concern about the translational crisis between laboratory research and patient bedside. Pointing to high rates of failure between nonhuman animal models and safety and efficacy in humans, organ chips and similar new approach methods have attracted substantial public and private investment. As human-cell-based alternatives to animal models, organ chips promise more predictive, efficient, and ethical platforms for pharmaceutical and toxicity testing. Engineered cultivation systems that enable cells to assemble into tissue-like structures (e.g. kidney, brain, …

Sewers To Solutions: A Guide To Wastewater Pathogen Monitoring

Faculty, Staff and Students Publications

Wastewater-based epidemiology (WBE) is the analysis of wastewater to detect pathogen levels or activity for public health awareness or action. Pioneered in the 1940s, WBE underwent a resurgence during the COVID-19 pandemic, providing important information about number of cases, outbreaks, and seasonal impact. With advancements in detection technologies and growing interest in environmental surveillance, WBE is poised to become a standard practice in public health monitoring. Here, we provide an overview of the current state of the art of pathogen WBE, including methods of molecular detection, analysis of wastewater data, real-world applications and programs, public health interventions, and benefits and …

Effect Of Graphene Oxide On The Upconversion Photoluminescence Behavior Of Er/Yb Co-Doped Pvdf-Go Composite Nanofibers, Saptasree Bose, Jack Ryan Summers, Bhupendra B. Srivastava, Karen Lozano, Victoria Padilla-Gainza

Mechanical Engineering Faculty Publications

Upconversion photoluminescence (UCPL) materials, particularly rare-earth (RE) doped nanoparticles, have garnered significant attention due to their ability to convert near-infrared (NIR) excitation into visible emission, offering benefits such as high photostability, long lifetimes, low autofluorescence, and deep tissue penetration. Among various platforms, polymer-based one-dimensional (1D) nanofibers with in-situ lanthanide doping remain relatively unexplored, despite their superior mechanical flexibility, processability, and potential for improved luminescence performance. In this study, we report the fabrication and UCPL quenching behavior of Er3+/Yb3+ co-doped polyvinylidene difluoride (PVDF) nanofibers incorporated with graphene oxide (GO), synthesized for the first time using the scalable Forcespinning® technique. PVDF, a …

A Position Statement On Endovascular Models And Effectiveness Metrics For Mechanical Thrombectomy Navigation, On Behalf Of The Stakeholder Taskforce For Artificial Intelligence-Assisted Robotic Thrombectomy (Start), Harry Robertshaw, Anna Barnes, Phil Blakelock, Raphael Blanc, Robert Crossley, Rebecca Fahrig, Ameer E. Hassan, Benjamin Jackson, Lennart Karstensen

School of Medicine Publications

Although we are making progress in overcoming infectious diseases and cancer, one of the major medical challenges of the mid-21st century will be the increasing prevalence of stroke. Occlusions in large vessels are especially debilitating, yet effective treatment—needed within hours to achieve best outcomes—remains limited because of geographic accessibility. One solution for improving timely access to mechanical thrombectomy in geographically diverse populations is the widespread deployment of robotic surgical systems. Artificial intelligence assistance may enable the safe and effective upskilling of operators in this emerging therapeutic delivery approach. Our aim was to establish consensus frameworks for developing and validating artificial …

“They Told Me To Succeed Where They Couldn’T”: Parent Support And Stem Motivation Among Stem Majors From Low Socioeconomic Status Backgrounds, Christine R. Starr, Tess A. Shirefley

Human Development & Family Science Publications and Presentations

Grounded in situated expectancy-value theory, this retrospective mixed-methods study examined how parent support during adolescence relates to STEM (science, technology, engineering, and math) motivation among low SES undergraduates currently majoring in STEM (n = 222; 86% women; 53% White, 19% Latine, 17% Asian, 7% Black). Past work has demonstrated that parent support positively relates to STEM motivation. However, few studies have examined this pattern amongst low socioeconomic status (SES) students, defined as students who are first-generation and/or from low-income backgrounds. Open-response thematic analysis revealed that socioemotional support, instrumental support, and role models were the most common forms of support for …

“But How Does Flying Work On Gravity When You Just Go Up?”: An Investigation Of Children’S Science Questions While Reading Life And Physical Science Books In Early Childhood, Tess A. Shirefley, Campbell Leaper

Human Development & Family Science Publications and Presentations

Children’s question-asking during early childhood plays a central role in cognitive development, reflecting children’s natural curiosity about the world. While research on early science learning has focused on informal contexts (e.g., home) where adults play a key role, less is known about children’s own contributions during these interactions, particularly across different science domains. Our study investigated how children aged 4 to 7 years engage in scientific inquiry by comparing the types of questions children asked while reading a life science book and a physical science book. We recorded 93 mother–child dyads reading two science books from the popular Let’s-Read-and-Find-Out-Science series. …

Amino Acids And Lean Mass Accretion In Preterm Neonates

Faculty, Staff and Students Publications

Purpose of review: This review evaluates recent evidence on how total protein and energy intake, amino acid composition, and nutrient delivery modality influence protein synthesis in preterm neonates, with the goal of informing nutritional strategies to support optimal lean mass accretion and growth.

Recent findings: Preterm neonates exhibit anabolic resistance to feeding due to impaired insulin and amino acid signaling in skeletal muscle. Enteral nutrition, especially fortified human milk, supports better lean mass accretion and neurodevelopment than parenteral nutrition. Intermittent bolus feeding and pulsatile leucine supplementation during continuous feeding further enhance mTORC1-dependent translation initiation signaling and protein synthesis efficiency in …

Agglomerama, Lee Anne Fennell

Public Law and Legal Theory Working Papers

No abstract provided.

An Engine, Not A Vessel: Place, Politics, And Health In The United States, Philip B. Rocco

Political Science Faculty Research and Publications

Social scientists often treat places as containers for social and economic phenomena that shape health outcomes. Yet this analytic practice conceals more than it reveals. Local governments in the United States should be understood as engines of both health promotion and stratification. As the contributions to this symposium suggest, governments not only occupy a formal place in the U.S. public health system, their decisions on everything from housing to transportation infrastructure can also have profound impacts on health outcomes. Local political economies likewise renegotiate the parameters of acceptable health interventions, public understandings of health disparities, and the status of population …

The Impact Of Users On The Operational Effectiveness Of Residential Photovoltaic Systems In Fragile-Grid Contexts: Iraq As A Case Study, O. Al-Hafith, B. Al-Hafiz, Z. Alhafedh

School of Art, Design and Architecture

Residential photovoltaic (PV) systems are increasingly promoted as key components of low-carbon and intelligent buildings. While extensive research has examined technological and climatic influences on PV performance, limited attention has been given to how users operate PV systems and the operational challenges that arise, particularly in fragile-grid contexts where PV systems function as primary electricity sources. This study addresses this gap by exploring user practices and identifying operational challenges affecting residential PV system performance in Iraq, a high-solar context characterised by persistent electricity supply interruptions. A mixed-methods approach was adopted, combining operational data from 30 PV system loggers with survey …

Findings And Recommendations From The State Of The Art (Sota) Conference On Nursing Research To Improve Veteran Outcomes, David Atkins, Catherine Battaglia, Elizabeth Burkhart, Renee Colsch, Marguerite Daus, Heather Gilmartin, Nipa Kamdar, Melissa Knox, Ann Kutney-Lee, Christine M Olney, Kathryn Rugen, Tracy Weistreich, Sheila Cox Sullivan, On Behalf The Nursing Sota Planning Committee

Faculty, Staff and Students Publications

The Veterans Health Administration (VHA), the largest employer of nurses in the United States, has more than 120,000 nursing personnel providing care to over 9 million Veterans across diverse settings. Despite nursing's central role in delivering and sustaining care, research on strengthening the nursing workforce and optimizing nursing practice has remained underdeveloped in VHA. To address this gap, VHA's Office of Research and Development, in partnership with the Office of Nursing Services, convened a State of the Art (SOTA) conference in November 2023 focused on nursing. The Nursing SOTA brought together nurses, researchers, operational leaders, and other stakeholders to review …

How Equity Changes, Samuel L. Bray

Public Law and Legal Theory Working Papers

In Trump v. CASA, the Supreme Court decisively rejected universal injunctions and offered a major decision about the law of equity. This Article grapples with a central question raised by CASA: if equity is not static, then what counts as legitimate innovation? This Article argues (1) that equity, in order to perform its functions, must have the capacity to innovate; (2) that any innovation should be in keeping with those functions and with equity’s own principles; and (3) that the primary stewards of the law of equity are the courts, not Congress. The vulnerabilities of Grupo Mexicano on these points …

Valuing Future Lives, Daniel J. Hemel, Jonathan S. Masur

Public Law and Legal Theory Working Papers

Federal regulation often involves a tradeoff between monetary costs in the present and life-saving benefits in the future. A central question in regulatory cost-benefit analysis is how to assign a present dollar value to future lives so that future lives and present dollars can be compared. For regulations that are projected to prevent deaths years or decades down the road, agencies make two key analytical moves. First, they adjust the value of a statistical life upward to reflect the fact that society’s willingness to pay to save lives will rise as people become wealthier in the future. Second, they discount …

Administrative Self-Constitutionalism, Brian Lipshutz

Public Law and Legal Theory Working Papers

Since the days of the Interstate Commerce Commission, federal agencies have generally refused to address the constitutionality of statutory provisions. They have offered little reasoning to justify that refusal, yet scholars have generally accepted it. This Article explains why agencies can—and should—address constitutional challenges to statutory provisions.

Agencies have the power to assess the constitutionality of statutory provisions. They already exercise a similar authority when they apply the canon of constitutional avoidance and consider the constitutionality of individual actions. There is no basis for stopping short of addressing challenges to statutes. And many scholars have recognized that, as a formal …

The Protective Power Of Psychological Resources In Mitigating Burnout And Enhancing Flourishing, Dylan R. Polkinghorne, David J. Radosevich, Deirdre M. Radosevich, Dianne D. Murphy, Laken James, Sue S. Craver

Management Faculty Research and Publications

Purpose

This study explores how burnout mediates the relationships between critical psychological resources, specifically resilience, flow and self-efficacy, and flourishing in contemporary work environments.

Design/methodology/approach

Data from 374 participants, including undergraduate students at a regional comprehensive university in the Midwest and full-time working adults in the USA, were analyzed using mediation analysis in MPlus 8.11 to assess the indirect and direct effects among burnout, psychological resources and flourishing in a work environment.

Findings

Results indicate that self-efficacy significantly predicts lower burnout levels and higher flourishing. Resilience and flow were negatively associated with burnout, reducing its impact; however, the direct effects …

Likelihood-Based Inference For Random Networks With Changepoints, Daniel Cirkovic, Tiandong Wang, Xianyang Zhang

Mathematical and Statistical Science Faculty Research and Publications

Generative, temporal network models play an important role in analyzing the dependence structure and evolution patterns of complex networks. Due to the complicated nature of real network data, it is often naive to assume that the underlying data-generative mechanism itself is invariant with time. Such observation leads to the study of changepoints or sudden shifts in the distributional structure of the evolving network. In this paper, we propose a likelihood-based methodology to detect changepoints in undirected, affine preferential attachment networks where, upon introduction, a new node selects one old to attach to with probability proportional to its degree. In particular, …

Evidence For A Spectral Break Or Curvature In The Spectrum Of Astrophysical Neutrinos From 5 Tev To 10 Pev, Karen Andeen

Physics Faculty Research and Publications

We report improved measurements of the all flavor astrophysical neutrino spectrum with IceCube by combining complementary neutrino samples in two independent analyses. Both analyses show evidence of a harder spectrum at energies below  ∼30  TeV compared to higher energies where the spectrum is well characterized by a power law. The spectrum is better described by a log parabola or a broken power law, the latter being the preferred model. Both, however, reject a single power law over an energy range 5 TeV–10 PeV with a significance  >4⁢𝜎, providing new constraints on properties of cosmic neutrino sources.

Black Hole Spectroscopy And Tests Of General Relativity With Gw250114, Jaclyn (Jax) Sanders

Physics Faculty Research and Publications

The binary black hole signal GW250114, the loudest gravitational wave detected to date, offers a unique opportunity to test Einstein’s general relativity (GR) in the high-velocity, strong-gravity regime and probe whether the remnant conforms to the Kerr metric. Upon perturbation, black holes emit a spectrum of damped sinusoids with specific, complex frequencies. Our analysis of the postmerger signal shows that at least two quasinormal modes are required to explain the data, with the most damped remaining statistically significant for about one cycle. We probe the remnant’s Kerr nature by constraining the spectroscopic pattern of the dominant quadrupolar (ℓ=m=2) …

A Review Of Data Interoperability As A Barrier To Non-Residential Building Energy Policy: Evidence From Ireland, Ankur Mitra, Kriti Bhalla, Ciara Ahern

Research Outputs: 2025-Present

Non-residential buildings account for a significant share of energy use and greenhouse gas emissions across the EU, yet evidence-based policy development remains hindered by fragmented and non-interoperable building data systems. This study evaluates the suitability of publicly available electronic datasets for characterising Ireland’s non-residential building stock and supporting bottom-up energy modelling in the context of the recast Energy Performance of Buildings Directive (EPBD 2024/1275/EU).A systematic scoping review of national government and institutional datasets was conducted using an adapted PRISMA-ScR approach. The analysis identified the national Energy Performance Certificate database and GeoDirectory as the only datasets with sufficient scale and detail …

Browser-Based Phishing Detection System Using Modern Web Technologies, Muhammad Arshad, Beena Sherin Kuriakose, Choo Wou Onn, Farhan Ahmad Siddiqui, Mohammad Shahid Kamal

Research Outputs: 2025-Present

Phishing remains one of the most persistent cybersecurity threats, exploiting human trust to steal sensitive information through deceptive websites. Traditional detection methods, reliant on blacklists and reactive reporting, offer limited protection against rapidly evolving zero-day attacks. To address these challenges, this study proposes and evaluates a hybrid browser-resident phishing detection framework that combines three complementary detection mechanisms: a locally executed Random Forest model using URL lexical features, lightweight real-time DOM structure analysis, and VirusTotal’s multi-engine reputation service. Communication between the client and server is optimised using gRPC over the QUIC protocol, ensuring secure, high-performance data exchange with built-in retry mechanisms …

A Memetic Nsga-Ii (M-Nsga-Ii) For Secure, Energy- And Latency-Aware Service Placement In Electronic Smart Grid Edge Networks, Saeed Javanmardi, Bahareh Pahlevanzadeh

Research Outputs: 2025-Present

Today, smart grids use small electronic nodes to run services, but deciding where to put each service is hard. If we use cheap nodes, we save energy, but they are slow and not very secure. If we use fast nodes, they use too much power. In this paper, we look at this problem with three goals: using less energy, lowering security risks, and cutting down time delays. We must also make sure no node gets too much work. To do this, we propose a memetic optimization method named M-NSGA-II. It improves the normal NSGA-II by adding a smart start, changing …

Regulatory Invisibility And Energy Poverty: Epc Exclusion, Traveller Mobile Homes And Ireland’S Low-Carbon Transition, Paul Lally, Ehiaze Ehimen, Mary Galvin, Ciara Ahern

Research Outputs: 2025-Present

Energy Performance Certificate (EPC) systems play a central role in residential decarbonisation by determining how dwellings are assessed, benchmarked and made eligible for retrofit support. However, these systems are largely designed around conventional, permanent, site-built housing and can exclude non-standard dwelling types. This paper examines the exclusion of permanently occupied Traveller mobile homes from Ireland’s EPC framework and considers the implications for energy poverty, retrofit policy and energy justice. Using a critical narrative synthesis, the study integrates academic literature, statutory reports, policy documents and community-based evidence to trace the relationship between Traveller accommodation policy, regulatory classification and contemporary decarbonisation frameworks. …

Regulatory Design Choices For Ai: The What, The Who And The How, Aziz Z. Huq

Public Law and Legal Theory Working Papers

This chapter identifies three common design choices that must be made in the course of an effort to regulate artificial intelligence “AI”). By isolating the way in which those different sovereign regulators approach these choices in respect to AI, it is possible to evaluate more clearly the likely effects of regulation, and to better understand aspects of regulatory design that to date have been overlooked. First, the “what” of AI regulation is not just a matter of how “AI” is defined, but also which element of the technology stack is targeted by law: compute, data, or models. Second, the “who” …

Redundant Public-Private Enforcement, Zachary D. Clopton

Public Law and Legal Theory Working Papers

Redundancy is a four-letter word. According to courts and scholars, redundant litigation is costly, unfair, and confounding. Modern civil procedure has a (nearly) maximalist preference for centralization, and various rules seek to limit duplicative suits within and across court systems. This seemingly dominant view stands in marked contrast to the reality of the modern regulatory state. Redundant public-private enforcement, in which public and private actors have overlapping authority to enforce the law, is ubiquitous. Redundant enforcement also is noticeably underrepresented in the substantial literature on private and public enforcement, which typically treats government agencies and private attorneys general as substitutes …

Intercornual Distance And Postoperative Reproductive Outcomes In Moderate-To-Severe Intrauterine Adhesions: A Retrospective Cohort Study, Changfa Shu, Xiaoming Guan, Jia Guo, Dabao Xu

Faculty, Staff and Students Publications

Study question: Does intercornual distance (ICD), as reflected by intrauterine stent size during hysteroscopic adhesiolysis, have an association with reproductive outcomes and provide information for postoperative risk stratification in women with moderate-to-severe intrauterine adhesions?

Summary answer: A smaller ICD was independently associated with a lower likelihood of clinical pregnancy within 1 year of the final hysteroscopy and may offer additional information for postoperative risk stratification in women with moderate-to-severe intrauterine adhesions.

What is known already: Reproductive outcomes following treatment for moderate-to-severe intrauterine adhesions vary considerably. Existing severity classifications offer limited discrimination within this group. The potential association between ICD and …

Molecular Heterogeneity Of Hpv-Associated Cancers And Strategies To Overcome Treatment Resistance, Danyal Daneshdoust, Anam Khan, Rani Mahyoob, Chongwen Cao, Zihao Yu, Nagireddy Putluri, Gennady Shvets, Haichang Li, Bo Zhao, Xuefeng Liu, Jenny Li

Faculty, Staff and Students Publications

Human papillomavirus (HPV) is a major driver of global cancer incidence, responsible for nearly all cervical cancers and a significant proportion of oropharyngeal, anal, and other anogenital cancers. Despite the availability of effective vaccines, HPV-associated cancers persist due to persistent infection, immune evasion, and the virus's ability to integrate into the host genome, contributing to molecular heterogeneity and therapeutic resistance. Here, we summarize molecular heterogeneity and the emerging combined therapeutic strategies. High-risk HPV types, notably HPV16 and HPV18, initiate carcinogenesis through persistent infection of epithelial basal cells and through the actions of the E6 and E7 oncoproteins, which disrupt the …