Digital Commons Network^™

Targeting Of The Oncogenic Fusion Ewsr1-Fli1 In Ewing Sarcoma By Crispr/Dcas9 Silencers, Shahama Taifour, Chee Wai Wong, Christopher Wallis, Edina Wang, Ash W.J. Tie, Eleanor Woodward, Charlene Waryah, Mahnaz Hosseinpour, Dilys Lam, Ryan Lister, Larissa Dymond, Andrew Woo, Peter J. Houghton, K. Swaminathan Iyer, Marck Norret, Cameron W. Evans, Louise Winteringham, Silvana Gaudieri, Pilar Blancafort

Research outputs 2022 to 2026

Despite the revolutionary impact of genome engineering tools in medicine, the safe and effective intracellular delivery of CRISPR remains a major obstacle to clinical applications. Here, we utilize precision molecular targeting and delivery strategies based on CRISPR-nuclease-dead Cas9 (dCas9) systems adapted for epigenetic repression (dCas9-Krüppel-associated box [KRAB]) to silence oncogenic drivers with high selectivity. As proof of principle, we target the EWSR1-FLI1 translocation, which encodes a chimeric and hard-to-drug oncogenic transcription factor driving approximately 85% of the cases of Ewing sarcoma (EWS)—an aggressive childhood malignancy. We describe the development of a programmable, non-viral polymeric system for the delivery of dCas9-KRAB …

Algorithm Envelopment In Platform Markets, Liang Chen, Zhou Zhou, Lester Chan

Research Collection Lee Kong Chian School Of Business

The theory of platform envelopment rests on network effects as the key mechanism for value creation, which nonetheless receives mixed support for its efficacy in determining competitive outcomes. We argue that the value of network effects depends on matching quality, which is a function of platform-specific algorithm technology and market-level data-driven learning. In formalizing these conceptualizations, we analyze a model that demonstrates how an entrant with a superior algorithm technology may outcompete an incumbent possessing a user base advantage, a strategy we call “algorithm envelopment.” By considering specific characteristics of data-driven learning, our analysis leads to propositions regarding the entry …

Brief For Jonathan H. Adler As Amicus Curiae Supporting Respondents And Affirmance, Jonathan Adler

Briefs

Global climate change presents many complex and intractable legal and policy questions. Assuming this Court has jurisdiction, the legal questions in this case are comparatively simple and straightforward. Nothing in federal law, let alone the Constitution, preempts state-law claims seeking relief from injuries allegedly caused or exacerbated by petitioners’ conduct.

At issue in this case is whether allegedly aggrieved parties, including subnational governments, may seek redress under state law from defendants otherwise subject to state court jurisdiction for harms allegedly caused or contributed to by petitioners’ conduct. In order to succeed, respondents will ultimately need to show that the damages …

Osmotic Dilators Vs. Foley Balloons: Bayesian Secondary Analyses Of The Dilafol Trial, Antonio F. Saad, Elenir B. C. Avritscher, Claudia Pedroza, Xiao Han, George R. Saade

Department of Obstetrics & Gynecology Faculty Publications

Background: Dilapan-S, a synthetic osmotic dilator used for pre-induction cervical ripening, has proven to be as effective as the Foley balloon in terms of vaginal versus cesarean delivery and has been associated with increased patient satisfaction. Nevertheless, its ability to lower cesarean rates and its cost-effectiveness remain poorly studied.

Objectives: To estimate the likelihood that synthetic osmotic dilators reduce cesarean deliveries and to evaluate their health system costs (2026 US$) and incremental cost-effectiveness compared to the Foley balloon during cervical ripening.

Study Design: Secondary Bayesian analyses were conducted using data from the single-center DILAFOL randomized controlled trial, which enrolled 419 …

Faith Between Coercion And Freedom: Religious Policy, Repressions, And Cultural Memory In Ukraine From The Soviet Era To The Present, Andrii Fesenko, Illya Lukovenko

Occasional Papers on Religion in Eastern Europe

A comprehensive historical and religious studies analysis of the evolution of Church- state relations, repressive practices, and transformations of cultural memory in Ukraine from the Soviet era to contemporary wartime challenges. The mechanisms of Soviet "spiritual genocide" as an institutional prelude to the Holodomor are examined, accompanied by the destruction of religious infrastructure, confiscation of property, and deprivation of legal status of religious communities. The formation of the contemporary Ukrainian model of Church- state relations, which is grounded in the principles of religious pluralism, partnership, and the separation of Church and state as a direct antithesis to state-imposed totalitarian atheism. …

The Social Role And Significance Of Religion For Ukraine Today – Historical Dynamics And Current Contributions, Olena Svysiuk

Occasional Papers on Religion in Eastern Europe

The paper delivers an analysis of Ukrainians’ religious worldview, tracing its development and transformation under historical, social and political influences. The contribution of the main Christian denominations − Orthodoxy, Greek-Catholicism and Protestantism − to national identity-building, the shaping of moral values, social cohesion and civic engagement is outlined. The work highlights how religion is deeply entwined with Ukrainian traditions, spirituality, and political life, serving as both a moral compass and a catalyst for social change. It also points to the churches’ social ministry − humanitarian, educational and psychological support − during the full-scale war. The involvement of religious institutions as …

Religious And Cultural Dimension Of The "Ringing Cedars Of Russia" Movement In The Context Of Hybrid Warfare, Oleksandr Lukyanenko, Vitaly Dmytrenko, Vita Dmytrenko

Occasional Papers on Religion in Eastern Europe

The article is devoted to a comprehensive religious analysis of the neo-religious movement “The Ringing Cedars of Russia,” based on the works of Vladimir Megre and the image of the prophetess Anastasia. The study covers the ideological and doctrinal foundations of the movement, its socio-cultural practices, the functioning of tribal settlements, as well as mechanisms of influence on individual and collective consciousness. Particular attention is paid to the concepts of “Vedrussia”, the sacralization of “Russian space” and the mythologization of Russia’s calling to revive the “primitive civilization of harmony.” The analysis shows that the movement, while declaring ecological and humanistic …

Two Fronts Of War: Physical And Spiritual: A Conversation With The Head Of The Chaplaincy Service Of The Land Forces Of The Armed Forces Of Ukraine– Larysa Polianska, Valentyna Kuryliak

Occasional Papers on Religion in Eastern Europe

She is an officer – and a woman. Emphasizing that she is not a military chaplain herself, she describes her role as a manager of the spiritual front. She is responsible for organizing the fulfillment of soldiers’ spiritual and religious needs and coordinating military chaplaincy activities. This conversation with Colonel Larysa Polyanska explores what it means for a woman to lead the chaplaincy service of the Land Forces of the Armed Forces of Ukraine, the reality of two fronts – physical and spiritual – and the pain of loss, prayer, and the power of words.

A Ukrainian Refugee Helping Her Fellow Refugees; Interview With Anya Starzhevska, Mark Elliott

Occasional Papers on Religion in Eastern Europe

Anya Starzhevska began helping her fellow Ukrainian refugees very soon after her own flight from Odesa to Warsaw in February-March 2022. Based at Warsaw Bible Church, she has taken on myriad administrative responsibilities including assistance for Ukrainian refugees in transit to farther west--Warsaw's main railway station is a 20-minute walk from the New Life Center at Warsaw Bible Church. Other roles she has been filling include facilitating the provision of shelter, food, and clothing for refugees; gatherings of Ukrainian refugee entrepreneurs; trauma care sessions with refugee mothers and children, and language and professional training events. On occasion she has also …

Ten Signatories, A Hundred Communities: Pluralization Without Consolidation In Slovenian Protestantism, Katja Brkič Golob

Occasional Papers on Religion in Eastern Europe

This article examines why contemporary Slovenian Protestantism exhibits a dual structure: a low‑variance Lutheran core (the Evangelical Church of the Augsburg Confession - ECAC) and a high‑variance neo‑Protestant field (mainly Pentecostal, Charismatic, Evangelical, and some Baptist communities). Using the public Register of Churches and Other Religious Communities as an administrative tracer of organizational volatility (first registrations, renamings, deletions), and situating findings in census/survey context, the study shows that post‑1991 legal liberalization enabled rapid formalization without automatic consolidation. A four‑lens framework—historico‑legal, sociological (church–sect–mysticism; religious‑economy), ecclesiological (order vs. movement), and psychological (charisma and its routinization; risks of authoritarian patterns)—explains why tensions in …

Disenchantment Of The World In The Context Of The Russian-Ukrainian War,, Olga Dobrodum, Eduard Martyniuk, Olena Nykytchenko, Mykola Palinchak, Ruslana Tkachenko

Occasional Papers on Religion in Eastern Europe

The article analyzes Max Weber's concept of the "disenchantment of the world" («Entzauberung der Welt») in the context of the full-scale Russian-Ukrainian war, which began with Russia's invasion in February 2022 and continues to the present. The author examines disenchantment as a process of rationalization and desacralization of society, tracing its development from ancient origins (Epicurus) and monotheistic traditions to contemporary interpretations (Adorno and Horkheimer, Barthes, Baudrillard, Habermas, Taylor, Haraway, Latour). The paradoxical nature of the process is emphasized: secularization does not eliminate the sacred but transforms it into new forms—from commodity fetishism to digital eschatology and posthumanist animism.

The …

Religious Television Of Ukraine In Shaping Spiritual Identity In The Context Of Contemporary Media Practices, Oleh Sokolovskyi, Vadym Slyusar, Maksym Melnychuk, Yuliia Kondratiuk

Occasional Papers on Religion in Eastern Europe

The article is devoted to analysing religious television in Ukraine as a key institution of contemporary sacred communication, which shapes a new configuration of spiritual presence within the digital media space. Religious TV channels are examined as mediatized spaces for producing and transmitting symbolic meanings, within which traditional theological narratives are adapted to the demands of audiovisual culture, and the sacred acquires new forms of visualisation, emotional accessibility, and communicative dynamism. It is demonstrated that television broadcasting provides a unique format of spiritual support, enabling faith communities to participate in prayer practices, catechetical programmes, and moral-ethical discourse beyond the boundaries …

The Autonomy Of Bulgarian Theological Scholarship: Institutional Control And Discursive Transformation Under The Communist Regime (1944–1960s), Diana Petrova Tyurkedzhieva

Occasional Papers on Religion in Eastern Europe

The article examines the autonomy of theological scholarship in Bulgaria under the communist regime as part of the broader problem of academic freedom under authoritarian rule, focusing on 1944 to the 1960s. While existing research has primarily addressed the relationship between the Orthodox Church and the State through institutional restriction and political repression, this study analyses how theological scholarship was transformed institutionally and discursively. It combines historical and institutional analysis with an examination of speeches, public statements, and academic publications in ecclesiastical and theological periodicals. The article argues that the separation of the Faculty of Theology from Sofia University in …

The Symbolic Language Of Militarized Orthodoxy In Patriarchal Sermons, Architecture, And Pseudo-Historical Memory, Oleksandr Lukyanenko

Occasional Papers on Religion in Eastern Europe

The article is devoted to a comprehensive cultural and religious analysis of the processes of militarization of religious worldview in modern Russia using the example of public speeches of Patriarch Kirill of Moscow, as well as the symbolic space of the Main Temple of the Armed Forces of the Russian Federation. Particular attention is paid to the study of the mechanisms of sacralization of war through the integration of historical memory, Orthodox rhetoric and the state ideology of the “Russian world”. The study analyzes the peculiarities of the interpretation of World War II as the sacred foundation of modern Russian …

The Rise And Fall Of The First Atheist State: Albania’S Rediscovery Of Faith, Fatos Tarifa

Occasional Papers on Religion in Eastern Europe

This paper explores Albania’s unprecedented experience as the only modern state to constitutionally declare itself atheist. After World War II, Enver Hoxha’s communist regime sought to reshape society through radical ideological transformation. In 1967, the regime banned all religious practice, dismantled churches, mosques, and monasteries, and persecuted clergy. Religion was criminalized, while atheism was promoted as a central component of socialist identity, enforced through education, propaganda, and cultural policy. In 1976, Albania was proclaimed by its constitution the world’s first atheist state. The paper examines the historical circumstances that produced this extreme stance and its consequences: suppression of traditions, erosion …

2026-2027 Graduate Catalog, Morehead State University. Registrar's Office.

Morehead State Catalog Archive

2026-2027 graduate catalog for Morehead State University.

2026-2027 Undergraduate Catalog, Morehead State University. Registrar's Office.

Morehead State Catalog Archive

2026-2027 undergraduate catalog for Morehead State University.

Srgan-Based Deep Learning Framework For Wind Turbine Damage Detection From Sentinel-2 Imagery, Kübra Çakir, Onur Elma, Murat Kuzlu

Engineering Technology Faculty Publications

The operational reliability of wind turbines is critical for sustainable energy production in smart grids. This study proposes a remote monitoring approach using perceptually enhanced satellite imagery. Sentinel-2 multispectral data (10 m resolution) has been processed with a Super-Resolution Generative Adversarial Network (SRGAN) to improve visual quality to a perceptual resolution of 30 cm. Although true spatial refinement is not achieved, the sharper structural details enhance classification accuracy. The data set comprises 15,000 images—10,000 SRGAN-enhanced and 5000 augmented through rotation, zoom in, increasing brightness, noise addition, and blurring. A custom Convolutional Neural Network (CNN) has been trained to classify turbines …

Identifying Industry-Preferred Automation Software In Engineering: An Indeed-Based Analysis To Inform Engineering Technology Curriculum Design, Triet Minh Phan, Collins Okafor, Winifred Okafor, Devang Mehta, Mohsen Souissi, Jenora Waterman, Connie Mayberry, Misty Thomas, Orlando Ayala, Angie Price, Maurizio Manzo

Engineering Technology Faculty Publications

In the evolving field of automation engineering, staying aligned with industry software demands is critical to preparing graduates for the modern workforce. This study investigates the prevalence of leading industrial automation platforms—Rockwell / Allen-Bradley (RSLogix / Studio 5000), Siemens (TIA Portal / Step 7), and Schneider Electric (EcoStruxure / Unity Pro)—across job postings collected from Indeed using the keyword "automation engineering." The research compiles a structured dataset of job postings with seven fields: ID, Job Title, Organization, Rockwell / Allen-Bradley, Siemens, Schneider Electric, and Posting URL. Each entry is manually coded to indicate whether the listed software platforms are mentioned, …

Interpretable Machine Learning For Bridge-Pier Scour Prediction And Flood Resilience, Adil Khan, Dalya Ismael

Engineering Technology Faculty Publications

Bridge-pier scour is a leading cause of flood-induced bridge failure, yet practice still lacks transparent, physics-informed tools that link data-driven prediction with design guidance. This study develops an interpretable, physics-aware machine-learning framework to predict equilibrium scour depth and translate those predictions into actionable strategies for flood-resilient infrastructure. Using the 2014 U.S. Geological Survey Pier-Scour Database (569 laboratory cases), five models: Gradient Boosting, AdaBoost (Tree), XGBoost, Gaussian Process (RBF kernel), and Kernel Ridge (polynomial), were trained and evaluated with K-fold cross-validation. Model performance was evaluated using R², RMSE, and MAE. Gradient Boosting performed best, achieving training and testing R² of 0.99 …

Generative Ai And Llm Applications In Renewable Energy And Smart Grids: A Systematic Review For The Sustainable Energy Transition, Umit Cali, Ugur Halden, Merlinda Andoni, Ferhat Ozgur Catak, Si Chen, Benoit Couraud, Emre Kantar, Samuel Knapper, Ibrahim Kucukdemiral, Huseyin Kusetogullari, Murat Kuzlu, Yashar Mousavi, Sonam Norbu, Taha Selim Ustun, David Flynn

Engineering Technology Faculty Publications

The global energy transition toward decarbonization and digitalization requires advanced methods to manage decentralized, data-intensive cyber-physical energy systems. This systematic review analyzes 106 research studies on Generative Artificial Intelligence (GenAI) and Large Language Models (LLMs) in renewable energy and smart grids, organized into seven application clusters covering forecasting, system design, operation, reliability, data and cybersecurity, and energy markets. The review situates these applications within a Cyber-Physical-Social Systems (CPSS) framework. Results show that GANs dominate current applications (47.2%), followed by LLMs (10.4%) and VAEs (9.4%), with growing adoption of diffusion and score-based models (7.5% each). Selected studies report improved probabilistic forecasting …

Analytical And Semi-Analytical Modeling Of Solar Cells Using The Lambert W Function: A Comprehensive Review Of Equivalent Circuits, Adel El-Shahat, Martin Ćalasan, Snežana Vujoševic, Shady H. E. Abdel Aleem

Engineering Technology Faculty Publications

The modeling of photovoltaic (PV) cells through equivalent circuits forms a central element in the analysis, simulation, and optimization of solar energy systems. Traditional approaches often depend on iterative numerical methods to solve the implicit current–voltage (I–V) equations. In contrast, the Lambert W function has emerged as an effective mathematical tool that enables closed-form or semi-analytical expressions for a wide range of PV models. This paper presents a Lambert W-centered review of analytical and semi-analytical formulations for PV equivalent-circuit models, covering classical single-diode and multi-diode structures and modern variants incorporating additional elements, voltage-dependent parameters, and topology rearrangements. The models are …

A Large Language Model-Based Academic Advising Assistant For Engineering Technology Students, Murat Kuzlu, Vukica M. Jovanovic, Katherine Smith, Otilia Popescu, Adel El-Shahat, Ryan Cotton, Kayla Marie Seegers, William Austin Henderson

Engineering Technology Faculty Publications

In recent years, Artificial Intelligence (AI)-based solutions, particularly Large Language Models (LLMs), have been applied to a variety of domains, such as energy, finance, transportation, healthcare, and education. Among these domains, education has become increasingly popular due to strong interest among educators and students. This study proposes an academic advising assistant system that uses LLMs to help Engineering Technology (ET) students plan their course load based on their educational history, departmental course offerings, and personal constraints, such as their preferred semester course load. The proposed LLM-based academic advising assistant system maintains a database of students' course histories and upcoming course …

Artificial Intelligence (Ai) In Educating Next Generation Of Engineering Technology Students, Adel El-Shahat, Murat Kuzlu, Vukica M. Jovanovic, Katherine Smith, Abdullah Al Mamun, Otilia Popescu

Engineering Technology Faculty Publications

Artificial Intelligence (AI) is transforming education, particularly for electrical engineering technology (EET) students, by presenting adaptive learning, immediate responses, and unconventional tools. Therefore, this paper proposes investigating modern learning to employ AI in educating future electrical engineering technology students. Firstly, the paper explores how to shape AI knowledge for EET students, supplying them with hands-on skills in AI tasks, clarifying coding, data analysis, and AI ethical usage. Then, as educators, what are the efficient AI tools to utilize in teaching, such as tailored tutoring, automated code assessment, AI-driven design/simulation, lecture dictation, and smart content creation? Key tools, for instance, Google …

Deep Learning-Based High-Resolution Spectrogram Reconstruction For Robust Bearing Fault Diagnosis, Sabyasachi Biswas, Saifur Rahman Tushar, Md Ebtidaul Karim, Abdullah Alam Mamun, Mahathir Mohammad Bappy

Engineering Technology Faculty Publications

Accurate and reliable bearing fault diagnosis is critical for the safe and efficient operation of rotating machinery. Conventional time–frequency (TF) analysis techniques, such as the short-time Fourier transform (STFT), are limited by their fixed window sizes and the inherent trade-off between time and frequency resolution, often leading to suboptimal fault representation under varying operating conditions. To address these challenges, this paper proposes a deep learning-based framework that reconstructs high-resolution, noise-robust TF representations directly from raw vibration signals. The proposed model integrates a denoising encoder with a learnable TF transformation network to adaptively capture fault related frequency patterns without manual parameter …

Using A Study Journal To Support Class Engagement And The Development Of Entrepreneurial Mindset Habits, Otilia Popescu, Dimitrie C. Popescu

Engineering Technology Faculty Publications

Engineering Technology programs were historically introduced to support non-traditional students and offer college pathways for students working and having already a developing career. This is even more true in the current academic environment, with a large percentage of students enrolled in engineering technology programs being either fully or part-time employed, active or retired military, and at different stages in their lives, usually with families to care for. Often, non-traditional students attend classes online, either synchronously or even more often asynchronously, due to their schedule constraints. Course instructors regularly face schedule or time management constraints from the students’ side, and they …

Wip: Arduino-Based Pbl To Foster Entrepreneurial Mindset, Nathan Q. Holland, Vukica M. Jovanovic

Engineering Technology Faculty Publications

This work-in-progress paper examines a semester-long project-based learning initiative begun in an introductory engineering course during the Fall 2025 semester. The project aims to enhance students' hands-on experience by integrating information literacy, the engineering design process (EDP), and an entrepreneurial mindset (EM) [1]. The objective is to boost student confidence in teamwork, technical problem-solving, and application of skills, preparing them for future courses in their discipline. Students in this introduction to engineering course received an Arduino Uno R3 Controller board kit and additional sensors. They were tasked to develop a device addressing engineering in the medicine challenge of their choosing. …

An Empirical Framework For Evaluating Semantic Preservation Using Hugging Face, Nan Jia, Anita Raja, Raffi Khatchadourian

Publications and Research

As machine learning (ML) becomes an integral part of high-autonomy systems, it is critical to ensure the trustworthiness of learning-enabled software systems (LESS). Yet, the nondeterministic and run-time-defined semantics of ML complicate traditional software refactoring. We define semantic preservation in LESS as the property that optimizations of intelligent components do not alter the system's overall functional behavior. This paper introduces an empirical framework to evaluate semantic preservation in LESS by mining model evolution data from HuggingFace. We extract commit histories, $\textit{Model Cards}$, and performance metrics from a large number of models. To establish baselines, we conducted case studies in three …

Color-Blind Resilience: How Uniform Climate Standards Reproduce Environmental Inequality In The Rockaways, Aaryan M. Nair

Publications and Research

This paper examines how ostensibly uniform climate resilience standards can reproduce environmental inequality in socially uneven landscapes, using the Rockaway Peninsula in New York City as a critical case study. While flood-resistant building codes, zoning regulations, and insurance frameworks are designed to provide equal protection across flood-prone areas, this analysis argues that their “color-blind” application obscures and intensifies underlying disparities in financial capacity, housing conditions, and tenure. Drawing on environmental justice (EJ) theory, the paper identifies two key mechanisms through which inequality is reproduced. First, “code without capacity” demonstrates how uniform technical standards—such as elevation requirements under NYC Building Code …

Gendered Resistance: Women’S Strategies Against Military Dictatorships, Argentina And Chile, Maricarmen Canales-Moreno

Publications and Research

This article compares the Madres de Plaza de Mayo in Argentina and the Agrupación de Familiares de Detenidos Desaparecidos (AFDD) in Chile to examine how women transformed their identities as mothers, wives, and daughters into strategies of political resistance under military dictatorship. It argues that maternal imagery, public mourning, and the transformation of private grief into collective defiance enabled women-led human rights organizations to challenge authoritarian regimes while strategically drawing on gender roles those regimes sought to enforce. The article traces the emergence of both organizations, their occupation of public space, hunger strikes, legal action, and engagement with international human …