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Articles 27811 - 27840 of 28492
Full-Text Articles in Entire DC Network
Open Scholarly Information Systems: Status Quo, Challenges, Opportunities, Hannah Bast, Guillaume Cabanac, Paolo Manghi, Jian Wu, Marcel R. Ackermann
Open Scholarly Information Systems: Status Quo, Challenges, Opportunities, Hannah Bast, Guillaume Cabanac, Paolo Manghi, Jian Wu, Marcel R. Ackermann
Computer Science Faculty Publications
Over the past 30 years, a rich ecosystem of scholarly information systems has developed that openly provide their services to the scientific community. These systems include aggregators of bibliographic metadata (e.g., DBLP, OpenCitations, OpenAIRE Graph, OpenAlex, ORKG, Semantic Scholar, CiteSeerX, and CORE); publication, data, and software repositories (e.g., Arxiv.org, Figshare, Zenodo, Software Heritage, and Dataverse); and PID authorities (e.g., ORCID, ROR, Crossref, and DataCite). This interdisciplinary Dagstuhl Seminar "Open Scholarly Information Systems: Status Quo, Challenges, Opportunities" (25381) was the first of its kind to bring together practitioners from this ecosystem, as well as researchers investigating related questions or relying on …
Privacy-Preserving Federated Learning With Optimized Ensemble Weighting And Knowledge Distillation For Covid-19 Detection From Non-Iid Medical Imaging Data, Richard Annan, Hong Qin, Robert Newman, Madhuri Siddula, Letu Qingge
Privacy-Preserving Federated Learning With Optimized Ensemble Weighting And Knowledge Distillation For Covid-19 Detection From Non-Iid Medical Imaging Data, Richard Annan, Hong Qin, Robert Newman, Madhuri Siddula, Letu Qingge
Computer Science Faculty Publications
Medical imaging enables rapid and accurate diagnosis of COVID-19, with CT scans proving especially effective. However, data privacy concerns limit collaborative model development across hospitals. To address this issue, we introduce a novel federated learning framework. It is referred to as Independent Knowledge Distillation with post-Ensemble Federated Learning (IKDEFL). Differential Privacy (DP) is integrated into the framework to improve privacy guarantees. Three DP mechanisms are evaluated. These include Fixed Gaussian, Gaussian Adaptive, and Tree Adaptive. The evaluation has been conducted on heterogeneous and Non-Independent and Identically Distributed (Non-IID) datasets. These datasets reflect real-world hospital scenarios. Results show that IKDEFL significantly …
Guidelines For Automatic Grading Of Student Essays Using Large Language Models, Diwakar Yalpi, Sruta Keerti Kasula, Ravi Mukkamala
Guidelines For Automatic Grading Of Student Essays Using Large Language Models, Diwakar Yalpi, Sruta Keerti Kasula, Ravi Mukkamala
Computer Science Faculty Publications
Automated essay evaluation using large language models (LLMs) has emerged as a promising approach to support scalable and consistent educational assessment. However, the effectiveness of LLM-based grading varies significantly across evaluation dimensions and is highly influenced by prompt design and model selection. In this study, we evaluate five state-of-the-art LLMs across five rubric-based categories: Relevance to Question, Reasoning and Critical Thinking, Evidence and Examples, Organization, and Clarity and Writing Quality. We systematically investigate the impact of three prompting strategies, including rubric-only prompting, exemplar-based prompting (with and without rubric guidance)(Original and Refined prompt designs) incorporating structured instructions. Additionally, a prompt ablation …
Isotropic Shrinkage Of Patterned Vacancies Enables Three-Dimensional Nanoprecise Metastructures For Visible Light Applications, Quansan Yang, Gaojie Yang, Takahiro Nambara, Hiroyuki Kusaka, Yuichiro Kunai, Alex C. Matlock, Corban Swain, Brett Pryor, Yannick Salamin, Daniel Oran, Hasindu Kariyawasam, Ramith Hettiarachchi, Dushan Wadduwage, Marin Soljačić, Peter T. C. Soflaei, Edward S. Boyden
Isotropic Shrinkage Of Patterned Vacancies Enables Three-Dimensional Nanoprecise Metastructures For Visible Light Applications, Quansan Yang, Gaojie Yang, Takahiro Nambara, Hiroyuki Kusaka, Yuichiro Kunai, Alex C. Matlock, Corban Swain, Brett Pryor, Yannick Salamin, Daniel Oran, Hasindu Kariyawasam, Ramith Hettiarachchi, Dushan Wadduwage, Marin Soljačić, Peter T. C. Soflaei, Edward S. Boyden
Computer Science Faculty Publications
Three-dimensional metastructures with nanoscale feature sizes exhibit unique properties compared with structures with larger feature sizes, but are difficult to fabricate. Here we introduce implosion carving (ImpCarv), a method for photopatterning vacancies of complex geometry throughout materials, followed by isotropic shrinkage (>10-fold). ImpCarv works by photoactivating sensitizers to generate reactive oxygen species that cleave a swollen hydrogel at defined points, followed by controlled shrinkage via dehydration. ImpCarv creates three-dimensional metastructures where the refractive index of each point throughout a material can be specified with nanoscale precision via material presence or absence. By leveraging refractive index programmability for precise phase …
A Survey On Generative Ai For Detector Effects Unfolding In Particle And Nuclear Physics, Tareq Alghamdi, Tommaso Vittorini, Jitao Xu, Marco Battaglieri, Derek I. Glazier, Glòria Montaña, Giorgio Foti, Alessandro Pilloni, Nobuo Sato, Yaohang Li
A Survey On Generative Ai For Detector Effects Unfolding In Particle And Nuclear Physics, Tareq Alghamdi, Tommaso Vittorini, Jitao Xu, Marco Battaglieri, Derek I. Glazier, Glòria Montaña, Giorgio Foti, Alessandro Pilloni, Nobuo Sato, Yaohang Li
Computer Science Faculty Publications
In particle and nuclear physics, “detector effects unfolding” can be viewed as a highdimensional inverse problem whose goal is to recover the true event distributions from observed experimental data corrupted by detector-induced distortions. Recent advances in generative AI have positioned data-driven and machine learning-based approaches as powerful alternatives to traditional unfolding techniques, offering superior scalability to high-dimensional data, capability of learning complex detector responses, and the ability to operate directly at the event level. We survey state-of the-art generative AI-based models for detector folding and unfolding. We review existing architectures and training strategies, and highlight recent methodological advances and open …
Replicatorbench: Benchmarking Llm Agents For Replicability In Social And Behavioral Sciences, Bang Nguyen, Dominik Soós, Qian Ma, Rochana R. Obadage, Zack Ranjan, Sai Koneru, Timothy M. Errington, Shakhlo Nematova, Sarah Rajtmajer, Jian Wu, Meng Jiang
Replicatorbench: Benchmarking Llm Agents For Replicability In Social And Behavioral Sciences, Bang Nguyen, Dominik Soós, Qian Ma, Rochana R. Obadage, Zack Ranjan, Sai Koneru, Timothy M. Errington, Shakhlo Nematova, Sarah Rajtmajer, Jian Wu, Meng Jiang
Computer Science Faculty Publications
The literature has witnessed an emerging interest in developing and evaluating AI agents for automated assessment of research claims in scientific papers. Existing benchmarks focus primarily on the computational aspect of this task, testing agents' ability to reproduce or replicate research outcomes when having access to the code and data. This setting, while foundational, (1) fails to capture the inconsistent availability of new data for replication as opposed to reproduction, and (2) lacks ground-truth diversity by focusing exclusively on fully reproducible or replicable papers, thereby failing to evaluate an agent's ability to identify non-replicable research. Furthermore, most benchmarks only evaluate …
Exploit Machina, Andrea Matwyshyn
Exploit Machina, Andrea Matwyshyn
Faculty Scholarship
Over half a century ago, Hannah Arendt cautioned us to “think what we are doing” when we build new technologies. Engaging with her counsel and a set of historical case studies, this Article frames what it calls exploit machina problems. Exploit machina refers to situations where broken technologies and broken governance combine to irreparably harm the public. In other words, exploit machina involves organizational choices to knowingly leverage technology as part of legally problematic conduct, including various forms of fraud. In the language of data science, exploit machina situations implicate strategic decisions in building and managing artificial intelligence (AI); they …
Community Engagement Newsletter, January 2026, University Of Northern Iowa. Office Of Community Engagement.
Community Engagement Newsletter, January 2026, University Of Northern Iowa. Office Of Community Engagement.
Community Engagement Newsletter
Contents:
--- UNI Earns Carnegie Elective Classification for Community Engagement
--- UNI’s Day of Service - April 8, 2026
--- Engaged Department Institute: Save the Date, May 26-27
--- Volunteer & Internship Explore-A-Ganza
--- Community Engagement Celebration Day
--- UNI Engaged Podcast
--- Pack the Dome - Thank you!
Untrained Position-Encoded Multilayer Perceptron Network For Structured Illumination Microscopy Reconstruction, Sahil Sharma, Leonidas Zimianitis, Krishnendu Samanta, Balpreet Singh Ahluwalia, Joby Joseph, Dushan N. Wadduwage
Untrained Position-Encoded Multilayer Perceptron Network For Structured Illumination Microscopy Reconstruction, Sahil Sharma, Leonidas Zimianitis, Krishnendu Samanta, Balpreet Singh Ahluwalia, Joby Joseph, Dushan N. Wadduwage
Computer Science Faculty Publications
Structured Illumination Microscopy (SIM) enables super-resolution imaging by encoding high-frequency spatial information through patterned light. While traditional Fourier-based reconstruction methods are prone to artifacts under suboptimal conditions, recent deep learning approaches often require large training datasets and lack adaptability across different imaging setups. In this work, we present Position Encoded Multi-Layer Perceptron (PEM) network that leverages implicit neural representations (INRs) and SIM forward-model-driven modeling to reconstruct super-resolved images without any training data. PEM-SIM represents each spatial coordinate as a combination of sinusoidal functions across multiple frequencies, enabling rich encoding of fine spatial detail. A forward model grounded in SIM image …
Near Real-Time Adaptive Isotropic And Anisotropic Image-To-Mesh Conversion For Cerebral Aneurysm Simulations, Kevin Garner, Chander Sadasivan, Nikos Chrisochoides
Near Real-Time Adaptive Isotropic And Anisotropic Image-To-Mesh Conversion For Cerebral Aneurysm Simulations, Kevin Garner, Chander Sadasivan, Nikos Chrisochoides
Computer Science Faculty Publications
This paper presents two performance optimization techniques for a mesh adaptation method that is designed to help streamline the discretization of complex vascular geometries within the numerical modeling process. This method is integrated into a pipeline with an image-to-mesh conversion tool to generate adaptive anisotropic meshes from segmented medical images. The pipeline is shown to satisfy quality, fidelity, smoothness, and robustness requirements while providing near real-time performance for medical image-to-mesh conversion. Tested with two brain aneurysm cases and utilizing up to 96 CPU cores within a single, multicore node on Purdue University’s Anvil supercomputer, the parallel adaptive anisotropic meshing method …
Adaptive Self-Attention For Enhanced Segmentation Of Adult Gliomas In Multi-Modal Mri, Evan P. Savaria, Jiangwen Sun
Adaptive Self-Attention For Enhanced Segmentation Of Adult Gliomas In Multi-Modal Mri, Evan P. Savaria, Jiangwen Sun
Computer Science Faculty Publications
Every year there are an estimated 80,000–90,000 new glioma cases, highlighting the need for reliable imaging-based decision support. Although deep learning has improved tumor sub-region segmentation, many state-of-the-art models fail to fully capture complementary information across T1, T1Gd, T2, and FLAIR MRI modalities and often operate as “black boxes,” limiting physician trust when precise delineation is critical for surgical planning, radiation targeting, and treatment monitoring. To address these limitations, we propose AIMS, an Adaptive Integrated Multi-Modal Segmentation framework that maintains modality-specific feature streams and employs adaptive self-attention within a hierarchical CNN-Transformer architecture to prioritize and fuse multi-modal MRI features. We …
Application Paths Of Semantic Modeling In Financial Fraud Detection And Risk Identification, Victor P. Gauthier, Daniel S. Wu
Application Paths Of Semantic Modeling In Financial Fraud Detection And Risk Identification, Victor P. Gauthier, Daniel S. Wu
Computer Science Faculty Publications
Financial fraud and risk pose significant threats to economic stability and individual well-being. Traditional detection methods often struggle to keep pace with increasingly sophisticated fraudulent schemes. Semantic modeling, which focuses on understanding the meaning and relationships within data, offers a promising avenue for enhancing fraud detection and risk identification. This review paper explores the application paths of semantic modeling in this domain. We begin with a historical overview of fraud detection techniques, highlighting the limitations of traditional approaches. Subsequently, we delve into core themes, including knowledge graph-based fraud detection and semantic rule-based inference for risk assessment. We then compare and …
Integration Of Hybrid Quantum-Neuromorphic Ai With Cloud, Edge, And High-Performance Computing Environments, Arun B. Prasad, Ajay Prasad, Dineshkumar Rajendran, Anurag Tiwari, T. Akilan, Islombek Khushvaktov
Integration Of Hybrid Quantum-Neuromorphic Ai With Cloud, Edge, And High-Performance Computing Environments, Arun B. Prasad, Ajay Prasad, Dineshkumar Rajendran, Anurag Tiwari, T. Akilan, Islombek Khushvaktov
Computer Science Faculty Publications
The convergence of quantum computing, neuromorphic learning, and distributed cloud infrastructures has occurred very rapidly, and intelligent systems are now providing new opportunities, but the challenge of instability, complexity of orchestration, and noise sensitivity remains in the way of practical integration. The proposed work is based on a hybrid quantum and neuromorphic architecture, which is the integration of event-based neuromorphic adaptation and quantum-assisted global optimization, orchestrated by cloud-HPC. The architecture presents the thermodynamically regularized learning and resourceful task scheduling to the probabilistic search and the continuous local adaptation. Experimental evaluation across financial modeling, medical imaging, and physical system prediction shows …
Contextual Scaffolding And Self-Efficacy: Supporting Computer Skill Development Among Blind Learners In India, Akshay Kolgar Nayak, Yash Prakash, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok
Contextual Scaffolding And Self-Efficacy: Supporting Computer Skill Development Among Blind Learners In India, Akshay Kolgar Nayak, Yash Prakash, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok
Computer Science Faculty Publications
Inclusive computer literacy education efforts, broadening the participation of blind or visually impaired (BVI) individuals, have gained traction in recent years. Existing literature investigating these efforts primarily draws evidence from affluent Global North contexts, where accessibility resources and legal frameworks are relatively more mature. Little is known about the in-situ teaching and learning challenges faced by trainers and BVI students, respectively, in resource-constrained, multicultural Global South countries like India. To address this knowledge gap, we conducted a four-month contextual inquiry at two computer training centers catering to 94 BVI students in India. We notably observed a rigid, experience-driven training environment …
Voxvista: Enhancing Screen Reading Experience For Online User Comments, Yash Prakash, Akshay Kolgar Nayak, Mohammed Shoaib Alyaan, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok
Voxvista: Enhancing Screen Reading Experience For Online User Comments, Yash Prakash, Akshay Kolgar Nayak, Mohammed Shoaib Alyaan, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok
Computer Science Faculty Publications
Online discussions have become integral to how people exchange ideas, form opinions, and participate in collective deliberation. While sighted users can comfortably engage with online discussions, blind users who are dependent on screen readers are forced to listen to long threads narrated in a single, monotonic voice that lacks prosodic variation, rhythm, or emotion. This robotic auditory experience not only deteriorates the user engagement with the content but also increases cognitive strain, by making it difficult to remain attentive and discern meaning beyond literal words. In an interview study, most blind participants reported that monotonous narration hindered their ability to …
Modeling Joint Visual Attention In Naturalistic Dyadic Interactions, Kuushini Thennakoon, Yasasi Abeysinghe, Bhanuka Mahanama, Vikas Ashok, Sampath Jayarathna
Modeling Joint Visual Attention In Naturalistic Dyadic Interactions, Kuushini Thennakoon, Yasasi Abeysinghe, Bhanuka Mahanama, Vikas Ashok, Sampath Jayarathna
Computer Science Faculty Publications
Joint visual attention (JVA) provides important insight into how individuals coordinate attention during social interaction. Egocentric eye tracking enables the study of JVA in natural, multi-user settings. This work presents a multi-stage framework to identify and analyze JVA using egocentric video and gaze data. The approach consists of three steps: spatiotemporal tube-based visual similarity, gaze-guided object detection, and attention pattern analysis using the ambient–focal coefficient K. Results show that object-focused collaborative activities exhibit high JVA, with object detection capturing higher joint attention than visual similarity, whereas conversation-based or independent activities show lower and more fragmented joint attention. Analysis of K …
Exploring Marshall–Olkin Models Through Bibliometric And Topic Modeling Approaches Uses Latent Dirichlet Allocation (1981-2025): A Study Based On Scopus Data, Humberto Llinás, Brian Llinás, Carlos López, Daniela Nuñez
Exploring Marshall–Olkin Models Through Bibliometric And Topic Modeling Approaches Uses Latent Dirichlet Allocation (1981-2025): A Study Based On Scopus Data, Humberto Llinás, Brian Llinás, Carlos López, Daniela Nuñez
Computer Science Faculty Publications
The Marshall–Olkin family of distributions has gained increasing attention in fields such as reliability engineering, survival analysis, financial risk modeling, and actuarial science because of its flexibility in modeling dependence among events and its wide range of extensions. Despite its growing relevance, a systematic understanding of how research on Marshall–Olkin models has evolved over time is still limited. This study addresses this gap by combining bibliometric techniques with topic modeling to analyze the structure and evolution of the scientific literature on Marshall–Olkin models. The analysis includes all 266 peer-reviewed publications on Marshall–Olkin models indexed in Scopus between 1981 and 2025. …
Exploring Large Language Models For Trustworthy Use: Insights From Research And Development, Sandeep Kalari, Sahithi Padidela, Vikas Ashok, Ravi Mukkamala
Exploring Large Language Models For Trustworthy Use: Insights From Research And Development, Sandeep Kalari, Sahithi Padidela, Vikas Ashok, Ravi Mukkamala
Computer Science Faculty Publications
Large Language Models (LLMs) are increasingly being adopted in a wide variety of domains, including sensitive domains such as healthcare and finance. However, persistent challenges such as unreliable data sources, privacy breaches, and hallucinated output continue to hinder their usage. We have experimented with several strategies to address these challenges. First, we developed BlockQwen, a blockchain-augmented framework that integrates decentralized trust validation, role-specific access control, and verifiable audit trails into the Qwen 2.5 LLM workflow. Second, we developed PrivAware, a multilayered privacy-enforcement framework, using a fine-tuned Flan-T5 model with self-attention masking, to safeguard data while maintaining high utility. Both systems …
A Comparative Analysis Of Explainable Ai (Xai) Techniques For Transparent And Reliable Image Classification, Sovon Chakraborty, Shakib Mahmud Dipto, Kevin R. Pilkiewicz, Michael L. Mayo, Pratip Rana
A Comparative Analysis Of Explainable Ai (Xai) Techniques For Transparent And Reliable Image Classification, Sovon Chakraborty, Shakib Mahmud Dipto, Kevin R. Pilkiewicz, Michael L. Mayo, Pratip Rana
Computer Science Faculty Publications
Evaluating the trustworthiness of black-box machine learning models remains a significant methodological challenge. Their lack of transparency and interpretability limits applicability, because stakeholders often seek transparency before trusting the results of black-box machine learning models. Explainable AI (XAI) methods provide for human-understandable justifications and informed decision-making of these black-box architectures. Therefore, it is imperative to select the proper XAI model tailored to specific tasks. In this research, we focus on examining four XAI techniques: PEEK, LRP, GRAD-CAM, and LIME to understand how they perform against each other for image classification tasks. We evaluate the performance, robustness, generalizability, noise stability, and …
Susceptibility To High-Fidelity Misinformation: An Eye-Tracking Analysis, Yasasi Abeysinghe, Gavindya Jayawardena, Enkelejda Kasneci, Sampath Jayarathna
Susceptibility To High-Fidelity Misinformation: An Eye-Tracking Analysis, Yasasi Abeysinghe, Gavindya Jayawardena, Enkelejda Kasneci, Sampath Jayarathna
Computer Science Faculty Publications
With the rise of online misinformation and AI-generated text, understanding human perception of news truthfulness is critical. In this study, we examine visual attention and cognitive processing using eye-tracking measures as individuals read fake and real news articles sharing nearly identical structure and imagery, differing only in subtle textual changes. Using the public FakeNewsPerception dataset, we analyze advanced gaze measures, including scanpaths, AOI transitions, and luminance-corrected pupil measures, beyond basic gaze features, in relation to news truthfulness and perceived believability. Results show that, given the high fidelity of the fake news, readers exhibited comparable visual scanning patterns, attention allocation across …
Memebuddy: Dialog-Style Audio Representations For Engaging Non-Visual Meme Experiences, Chirag Bhansali, Vikas Ashok, Hae-Na Lee
Memebuddy: Dialog-Style Audio Representations For Engaging Non-Visual Meme Experiences, Chirag Bhansali, Vikas Ashok, Hae-Na Lee
Computer Science Faculty Publications
Image memes are a pervasive form of online communication, widely used to convey humor, opinions, and cultural references. Prior work has explored making memes accessible to blind users, primarily through auto-generated descriptive captions. While these approaches improve comprehensibility and sometimes incorporate prosodic or emotional cues, they often fail to capture the humor, narrative structure, and contextual nuances that make memes engaging. We present MemeBuddy, a system that models memes as dialog, generating structured, multi-turn audio representations using role-based speakers. MemeBuddy reinterprets a meme as a conversation between two speakers, integrating extracted meme text with contextual knowledge implicitly inferred by a …
Distributed Semi-Speculative Parallel Anisotropic Mesh Adaptation, Kevin Garner, Polykarpos Thomadakis, Nikos Chrisochoides
Distributed Semi-Speculative Parallel Anisotropic Mesh Adaptation, Kevin Garner, Polykarpos Thomadakis, Nikos Chrisochoides
Computer Science Faculty Publications
This paper presents a distributed memory method for anisotropic mesh adaptation that is designed to avoid the use of collective communication and global synchronization techniques. In the presented method, meshing functionality is separated from performance aspects by utilizing a separate entity for each - a multicore cc-NUMA-based (shared memory) mesh generation software and a parallel runtime system that is designed to help applications leverage the concurrency offered by emerging high-performance computing (HPC) architectures. First, an initial mesh is decomposed and its interface elements (subdomain boundaries) are adapted on a single multicore node (shared memory). Subdomains are then distributed among the …
A Survey Of Ai Methods For Geometry Preparation And Mesh Generation In Engineering Simulation, Steven Owen, Nathan Brown, Nikos Chrisochoides, Rao Garimella, Xianfeng Gu, Franck Ledoux, Na Lei, Roshan Quadros, Navamita Ray, Nick Winovich, Yongjie Jessica Zhang
A Survey Of Ai Methods For Geometry Preparation And Mesh Generation In Engineering Simulation, Steven Owen, Nathan Brown, Nikos Chrisochoides, Rao Garimella, Xianfeng Gu, Franck Ledoux, Na Lei, Roshan Quadros, Navamita Ray, Nick Winovich, Yongjie Jessica Zhang
Computer Science Faculty Publications
Artificial intelligence is beginning to reduce the manual effort in the CAD-to-mesh pipeline. Written for meshing and geometry practitioners with limited AI background, this survey organizes recent work by workflow step. We cover part classification and segmentation, mesh quality prediction, and defeaturing. We review AI guidance for unstructured meshing, block-structured meshing in 2D and 3D, and volumetric parameterization, including reconstruction from implicit or sampled geometry. We also discuss parallel mesh generation and scripting automation via reinforcement learning and large language models. Across these topics, AI complements established geometry and meshing algorithms rather than replacing them. We conclude with practical lessons …
Dynamic Social Impact Theory And The Consolidation And Dispersal Of Clusters In Squid Game: The Challenge, Adrienne Darrah, Robert J. Darrah
Dynamic Social Impact Theory And The Consolidation And Dispersal Of Clusters In Squid Game: The Challenge, Adrienne Darrah, Robert J. Darrah
Iowa Journal of Communication
This study utilizes a dynamic social impact theory (DSIT) framework to analyze human influence on the popular Netflix television series Squid Game: The Challenge. A British reality competition, Squid Game: The Challenge is comprised of ten-episodes and features 456 contestants vying for $4.56 million. As contestants self-organize into social alliances, their shared attitudes, beliefs, and values transform the physical space into a dynamic social space. The creation of clusters through these alliances, the correlation between contestant attitudes and behaviors, and the consolidation of contestant attitudes and behaviors reflective of alliance needs is reinforced by the physical proximity of contestants, the …
Research News, Publications, 2026, Volume 1, Soumyajit Majumdar
Research News, Publications, 2026, Volume 1, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period of January 1 - March 31, 2026.
Prickle4 Drives Microenvironmental Remodeling And Resistance To Parp Inhibition In Idh-Mutant Glioma, Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T Huse, Bo Chen, Timothy A Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang
Prickle4 Drives Microenvironmental Remodeling And Resistance To Parp Inhibition In Idh-Mutant Glioma, Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T Huse, Bo Chen, Timothy A Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang
Faculty, Staff and Student Publications
Mutations in isocitrate dehydrogenase (IDH) genes sensitize gliomas to PARP inhibition (PARPi) by inducing epigenetic reprogramming of DNA damage repair circuits. However, tumors treated with PARPi eventually relapse despite initial responsiveness. In this study, it is demonstrated that the anti-angiogenic agent lenvatinib synergizes effectively with PARPi, resulting in substantial tumor regression and significantly extended survival. Genomic analysis of tumors reveals that PARPi induces widespread transcriptomic changes that are predominantly pro-inflammatory, thereby promoting tumor angiogenesis. Prickle4, a planar cell polarity protein, is identified as a critical mediator of PARPi-induced neovascularization. Targeting Prickle4 effectively overcomes PARPi resistance in these tumors. Collectively, these …
Digital Communication Strategies For Culinary Medicine In Cancer Prevention And Survivorship: Information-Seeking Habits And Content Preferences Of Online Cooking Media Among Adults Participating In Four Cancer Prevention And Control Cohort Studies, Margaret Raber, Sara Fares, Maria Vazquez, Larkin Strong, Carrie Daniel-Macdougall, Lorna Mcneill, Karen Basen-Engquist
Digital Communication Strategies For Culinary Medicine In Cancer Prevention And Survivorship: Information-Seeking Habits And Content Preferences Of Online Cooking Media Among Adults Participating In Four Cancer Prevention And Control Cohort Studies, Margaret Raber, Sara Fares, Maria Vazquez, Larkin Strong, Carrie Daniel-Macdougall, Lorna Mcneill, Karen Basen-Engquist
Faculty, Staff and Student Publications
Introduction
Poor diet and excess weight have been linked to increased risk for at least 13 types of cancer. Culinary medicine utilizes experiential cooking skill development to improve individuals’ capacity for healthy eating. Digital communication strategies offer pathways for scalable culinary medicine interventions, but little research has explored how online cooking tools could be leveraged for cancer prevention messaging. We conducted a cross-sectional survey study exploring online cooking information-seeking habits and content preferences among participants in four cancer prevention and control cohorts to inform future digital culinary medicine interventions.
Methods
A cross-sectional survey study was conducted with a convenience sample …
Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles And Therapeutic Function In Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, Charles S Cox
Freeze-Dried, Not Frozen: Lyophilized Mesenchymal Stromal Cell-Derived Extracellular Vesicles And Therapeutic Function In Neuroinflammatory Models, Janet R Ashley, Aidan M Collier, Scott D Olson, Charles S Cox
Faculty, Staff and Student Publications
Background: Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) offer a promising acellular therapy for immune modulation, but clinical translation is hindered by variability and storage constraints. Lyophilization (freeze-drying) could enable shelf-stable EV therapeutics, although its effects on biological activity remain incompletely defined.
Study design: We compared the immunomodulatory effects of frozen and lyophilized EVs from bone marrow (BM), adipose tissue (AD), and umbilical cord (UC) MSCs using lipopolysaccharide-stimulated rodent splenocytes and microglial models and human peripheral blood mononuclear cells (PBMCs). Variables included batch scale (small vs large), cytokine priming, and MSC source. Tumor necrosis factor alpha (TNF-α) secretion was measured …
Single-Cell Lineage Trajectory Defines Cyclin-Dependent Kinase Inhibitor-Sensitive Cells-Of-Origin In Esophageal Squamous Cell Carcinoma, Kyung-Pil Ko, Jie Zhang, Sohee Jun, Jae-Il Park
Single-Cell Lineage Trajectory Defines Cyclin-Dependent Kinase Inhibitor-Sensitive Cells-Of-Origin In Esophageal Squamous Cell Carcinoma, Kyung-Pil Ko, Jie Zhang, Sohee Jun, Jae-Il Park
Faculty, Staff and Student Publications
Background and aims: Understanding the cells of origin is essential for overcoming therapy resistance and improving early intervention strategies in esophageal squamous cell carcinoma (ESCC). Despite recent advances in genomic profiling, the precise cellular hierarchies and molecular programs driving ESCC initiation remain poorly defined.
Methods: We utilized machine learning-based single-cell trajectory analysis on 4-nitroquinoline 1-oxide-induced murine models and genetically engineered organoids to identify cellular lineages during tumorigenesis. Combined with gene regulatory network analysis, we identified transcriptional drivers of tumor initiation and employed transcriptome-based drug repurposing to predict compounds targeting these initiating populations.
Results: Our analyses revealed multiple distinct epithelial clusters …
Engineering Mutation Clones In Mammalian Cells With Crispr/Cas9, Zijun Huo, Jian Tu, Rachel Shoemaker, Dung-Fang Lee, Ruiying Zhao
Engineering Mutation Clones In Mammalian Cells With Crispr/Cas9, Zijun Huo, Jian Tu, Rachel Shoemaker, Dung-Fang Lee, Ruiying Zhao
Faculty, Staff and Student Publications
CRISPR, Clustered Regularly Interspaced Short Palindromic Repeat, as a powerful genome engineering system, has been widely accepted and employed in gene editing of a vast range of cell types. Compared to zinc finger nucleases (ZFNs) or transcription activator-like effector nucleases (TALENs), CRISPR shows a less complicated process and higher efficiency. With the development of different CRISPR systems, it can be used not only to knock out a gene but also to make precise modifications, activate or repress target genes with epigenetic modifications, and even for genome wide screening. Here we will describe the procedure of generating a stable cell line …