Digital Commons Network^™

Stem Cell-Derived Developmental Models For Translational Evaluation Of Disease And Therapy, Maria B. Paredes-Espinosa

Electronic Theses & Dissertations (2024 - present)

Human development as well as congenital and adult diseases emerge from coordinated interactions among multiple cell types, regulatory programs, and tissue compartments that remain largely unresolved. Conventional simple lineage-restricted in vitro systems poorly capture this complexity. My dissertation uses human stem cell-derived developmental models to study human cardiac morphogenesis and heart diseases and application of a networked neuron platform to explore senescence-associated neurodegeneration impact on Alzheimer’s neurons.

Elongating multi-lineage organized cardiac (EMLOC) gastruloids are a synthetic embryology model that co-generates contractile cardiomyocyte populations alongside mesenchymal, endothelial, epicardial-like, neural crest-associated, and neuronal cells within a shared in vitro developmental environment. Single-cell …

Next-Generation Computing Hardware: Advancements In Tantalum Oxide Reram For Ai And Neuromorphic Applications, Rajas Ravindra Mathkari

Electronic Theses & Dissertations (2024 - present)

The rapid development of artificial intelligence, machine learning, and data-intensive computing has exposed the fundamental limitations of conventional von Neumann architectures, in which energy and time are continuously lost transferring data between physically separate memory and processing units. In contrast, the human brain performs complex computations directly at the point of memory storage through billions of parallel synaptic connections, a paradigm known as in-memory computing. Realizing this in hardware requires memory devices that are fast, energy-efficient, non-volatile, and capable of storing multiple resistance levels in an analog manner. Resistive Random Access Memory (ReRAM) based on tantalum oxide (TaOx) is one …

From Sparks To Insights: An Aggregate Analysis On Arson And Explosive Data Reporting Published By The Atf (2014-2024), Zahra A. Khan

Electronic Theses & Dissertations (2024 - present)

This thesis provides an aggregate assessment of arson and explosives incidents reported by the Bureau of Alcohol, Firearms, and Tobacco, from 2014 to 2024. This thesis is written to highlight trends, investigative outcomes, and evolving patterns of criminal activity. Analysis of the data reveals notable shifts in incident frequencies, data distributions, and case resolution rates. This suggests both emerging technologies and changing operational dynamics that have affected long-term trends in arson and explosive incidents. Variations in incident types and investigative outcomes underscore the interplay between law enforcement priorities, resource allocation, and reporting practices over the ten-year period. The study also …

The Relationship Between State-Level Career And Technical Education (Cte) Policies And Secondary Student Enrollment In Construction, Manufacturing, And Health Sciences Cte Programs, Brittany A. Kitterman

Electronic Theses & Dissertations (2024 - present)

Across the United States, employers in construction, manufacturing, and healthcare report ongoing difficulty filling positions. These shortages have been driven by an aging workforce, increased demand, and high rates of retirement. Compounding these shortages, Federal investments such as the Infrastructure Investment and Jobs Act and the CHIPS Act have further increased demand. Career and Technical Education programs are well positioned to support workforce development and help close workforce shortages, but access and participation remain limited. Supported by Federal Perkins funding, states have enacted CTE policies to increase access and enrollment in CTE programs aligned with high-demand industries such as construction, …

Entropic Dynamics Approach To The Classical Limit Of Quantum Mechanics: Decoupling Of The Center Of Mass Motion For A Mesoscopic Particle, Fatimah Judayba

Electronic Theses & Dissertations (2024 - present)

In the Entropic Dynamics (ED) approach, quantum mechanics is derived from the principles of entropic inference and information geometry. The ED approach differs from other interpretations by making a clear commitment to distinguishing which variables are ontic (real) and which are epistemic. The classical limit for the center of mass (CM) coordinate is achieved for a large number of particles, M →∞, while Planck’s constant ℏ remains finite. Typically, the emergence of the classical limit requires decoherence through interactions with the external environment. In this work, we investigate whether the classical behavior of the CM coordinate in a mesoscopic system …

The Chemistry Of Red Lipstick: The Impact Red Lipstick Has On Society, Lilliana Weldeslassie

Electronic Theses & Dissertations (2024 - present)

Cosmetic chemistry is deeply embedded in everyday life, shaping the products people use from morning to night. Among these, red lipstick stands out as a formulation that blends complex chemistry with a cultural meaning. This thesis examines the scientific foundations of red lipstick through its chemical composition, pigment structure, toxicological history, analytical methods, and evolving sustainability practices. Historically, red lipsticks relied on high-risk ingredients such as lead, mercury, and other toxic metals, reflecting an era before chemical safety and regulatory oversight were incorporated.²¹ Modern formulations have established safer synthetic dyes, natural waxes, plant-based oils, and stabilizers created to optimize …

Corannulene: Optimized Synthesis And Four-Fold Reduction, Guy Rozenman

Electronic Theses & Dissertations (2024 - present)

Corannulene is a bowl-shaped π-conjugated fragment of the ball-shaped C₆₀-fullerene that undergoes stepwise multielectron reduction and can accept four electrons to form the aromatic tetraanion, C₂₀H₁₀⁴⁻. Prior literature has established this charge state in donor-solvated alkali-metal assemblies: early solution studies identified the formation of the tetraanion under lithium reduction in THF, and later X-ray diffraction crystallography demonstrated a triple-decker lithium sandwich in which two corannulene tetraanion decks encapsulate five Li⁺ ions. The central objective of this thesis is to determine whether the corannulene tetraanion can instead be isolated as a bulk solvent-free alkali-metal salt containing only corannulene and …

Specification Of Validated Groundwater Flow And Transport Models For Historical Perfluorinated Compound Dose Reconstruction, Cindy A. Arthur

Electronic Theses & Dissertations (2024 - present)

Per- and polyfluoroalkyl substance (PFAS) contamination in Hoosick Falls, New York, resulted from historical industrial activities, with groundwater transport identified as the primary pathway impacting the municipal wellfield within the Village of Hoosick Falls, whereas atmospheric deposition remains a potential source of private well contamination. This study employed two complementary methodologies to evaluate historical municipal and private well contamination: (i) groundwater flow and transport modeling of PFOA, PFOS, PFHxS, and PFNA within the village, and (ii) Geographic Information Systems (GIS)–based inverse distance weighting (IDW) interpolation of PFOA concentrations in private wells across the broader Town of Hoosick.

Groundwater modeling results …

On Quantum Processes And The Epistemic Constraints, Varun Immanuel Premkumar Immanuel

Electronic Theses & Dissertations (2024 - present)

This doctoral dissertation on the foundations of quantum theory tells the story of a conceptual protagonist I have called “Epistemic Constraint.” Here, epistemic constraints are the definite, intersubjectively agreeable, ordinary-language conditions under which experiments are described.

The usual formulation of the quantum measurement problem, which I call the Schrodingerian measurement problem, has the structure of an anomaly: if we take quantum theory at face value, we expect no definite values, and yet we see definite values in experiments. The responses to this problem have been either to solve it or to dissolve it. These responses, which have taken the form …

Combating Antibiotic Resistance With Plasmid-Dependent Phages, Rhiannon T. Mariano

Electronic Theses & Dissertations (2024 - present)

The alarming rise of carbapenem-resistant bacteria poses an urgent global health threat, driven in large part by the horizontal spread of carbapenemase-encoding plasmids (Ma et al., 2023). These plasmids are often highly mobile and transmissible, enabling rapid dissemination of resistance genes across diverse bacterial populations. Their mobility is largely mediated by conjugation, a process dependent on the formation of pili, which serve as physical bridges for plasmid transfer between cells (Murray et al. 2022; San Millan and MacLean 2017; Virolle et al. 2020). Beyond their role in gene exchange, these pili also act as entry points for a unique class …

Advancing Data Extraction Workflows For Single-Case Design Meta-Analysis Using Large Language Models, Yaosheng Lou

Electronic Theses & Dissertations (2024 - present)

Single-case experimental designs (SCEDs) are a form of longitudinal research that is particularly valuable for studying marginalized and underrepresented populations. Meta-analysis plays an essential role in synthesizing evidence across studies and enhancing the generalizability of findings. However, as interest in SCEDs grows and the evidence base expands, conducting meta-analyses has become increasingly labor-intensive and time-consuming. This dissertation addresses these challenges by examining the applicability of large language models (LLMs) for data extraction and meta-analytic dataset compilation in the context of SCED meta-analysis. Because LLM performance is influenced by model selection, prompt design, and the specific materials being extracted, this dissertation …

Cognate Awareness Training For Novice L2 Learners: Orthographic And Phonological Routes To Vocabulary Learning, Jennifer M. Martin

Electronic Theses & Dissertations (2024 - present)

Within the study of cross-linguistic influence, research on cognate facilitation has consistently shown that proficient bilinguals process cognates (e.g., English “sock” and German “Socke”) more efficiently than non-cognates. However, less is known about how novice adult learners may benefit from these similarities during the earliest stages of second language acquisition or how instructional interventions might facilitate this process. This dissertation addressed this gap through experiments with English-speaking adults learning German. A series of experiments examined the effects of cross-linguistic similarity and explicit cognate awareness training on vocabulary acquisition. Experiment 1A found robust similarity effects in written recall and …

High-Tcr Multivalence Vanadium Oxide Thin-Films From Deposition Parameter Control To Microbolometer Applications, Latika Susheel M. Chaudhary

Electronic Theses & Dissertations (2024 - present)

This thesis details the development of multivalence-nanostructured vanadium oxide (VOₓ) thin films for uncooled microbolometer applications, with a systematic optimization of magnetron-sputtering parameters. The temperature coefficient of resistance (TCR), resistivity, and optical response of VOₓ thin-film sensing layers are controlled by valence composition, grain growth, and surface morphology. The primary goal was to achieve a high TCR with low resistivity to improve thermal detector performance.

Multivalent VOₓ thin films were deposited on silicon, SiO₂, and glass substrates using DC magnetron sputtering. Three key parameters were systematically varied: Ar:O₂ ratio (18:2 to 15:5), deposition time (60–120 minutes), and DC power (300W …

Improving Modeling Of Corrosion Products In The Primary Circuit Of Light Water Reactors Through The Experimental Determination Of Crud Characteristics, Sri Saravana Konganapuram Narasimma Bharathi

Electronic Theses & Dissertations (2024 - present)

High-temperature water flowing through the coolant circuits in pressurized water reactors (PWRs) creates a harsh environment, deteriorating these materials. This corrosion results in the formation of oxide layer(s) primarily composed of nickel ferrites, iron oxides, nickel oxides, and other nickel-iron-chrome spinel oxides. Being exposed to fluid with high flow rates and pressure, these oxide layers can be eroded, resulting in particulate fouling due to the release of corrosion products (Chalk River Unidentified Deposits, CRUD) into the coolant circuit. When CRUD subsequently deposits on fuel surfaces, it negatively affects the fuel performance (heat transfer and fuel failure); in addition, the particles …

Hepatitis C Among Persons Who Inject Drugs In New York State: Progress Towards Elimination, Meredith A. Barranco

Electronic Theses & Dissertations (2024 - present)

Background: Hepatitis C virus (HCV) infection is one of the leading causes of liver disease in the United States (US) and worldwide. In the United States today, HCV is transmitted primarily through injection drug use (IDU) and therefore disproportionately impacts persons who inject drugs (PWID), a population with a range of complex social and health needs. HCV is not vaccine-preventable but can be cured in over 90% of cases with an 8–12-week course of daily direct-acting antiviral (DAA) medication. Since approval of curative medications in 2014, various jurisdictions have developed plans to eliminate HCV. In 2021, the New York State …

Audiovisual Motion Onset Asynchrony As Expectation Violation: Effects On Memory And Liking In Media Contexts, Sijia Song

Electronic Theses & Dissertations (2024 - present)

This research presents the first systematic investigation of motion-onset asynchrony (MOA) as a form of audiovisual temporal incongruency grounded in contemporary spatial audio and extended reality (xR) systems. MOA—the delay between the onset of visual and auditory motion—was manipulated at three levels (0 s, 1.1 s, 3 s) to test its effects on cognitive (memory) and affective (liking) outcomes during short 2D animated video viewing. Guided by inverted-U models of expectation violation, it was hypothesized that moderate MOA would be associated with the highest memory performance and liking ratings and that liking would mediate MOA’s effects on memory. Across two …

Nanostructured Cathode Catalysts For Aem Electrolysis: From Catalyst Design To Degradation And Hydrogen Dynamics, Yamini Kumaran

Electronic Theses & Dissertations (2024 - present)

Anion exchange membrane water electrolysis (AEMWE) presents a promising pathway toward cost-effective and sustainable hydrogen production by integrating the chemical robustness of alkaline systems with the compact, zero-gap design of proton exchange membrane electrolyzers. However, the widespread implementation of AEMWE is limited by the availability of highly active and durable platinum-group-metal (PGM)-free catalysts and by an incomplete understanding of their degradation behavior under realistic operating conditions.

This dissertation focuses on the development, characterization, and mechanistic investigation of nanostructured MoNi₄–MoO₂-based electrodes for efficient and stable hydrogen generation under alkaline and membrane-integrated environments. MoNi₄–MoO₂ nanorods …

Bio-Orthogonal Chemistry-Based Strategy To Turn-On And Turn-Off Crispr-Cas9 Gene Editing In Solution And In Live Cells, Bhoomika Pandit

Electronic Theses & Dissertations (2024 - present)

The CRISPR–Cas9 system is a widely popular tool for genome engineering. There is a strong interest in developing tools for temporal control of CRISPR-Cas9 activity to address some of the challenges and to broaden the scope of potential applications. In this thesis I describe two biorthogonal based approaches to either Turn-ON and Turn-OFF CRISPR-Cas9 gene editing.

In first project work I describe a bio-orthogonal chemistry-based approach to Turn-ON Cas9 nuclease activity with temporal precision. We report a TCO-acylimidazole reagent that acylates 2′-OH groups of RNA. Poly-acylation (“cloaking”) of RNA was optimized in vitro using a model 18-nt oligonucleotide, as well …

Cervical Ligament Systems In Sauropod Dinosaurs: What Support Is There?, Audrey Rose Williams

Masters Theses

"Sauropod dinosaurs, such as Diplodocus, have been the subject of numerous hypotheses about what ligamentous structures could have lifted and supported their long necks. Because the supportive tissues rarely fossilize, palaeontologists rely on osteological correlates on the bone to infer their nature. Options for supportive cervical ligaments in sauropods are mammal-style nuchal ligaments, avian-style interlaminar elastic ligaments, reptilian-style supraspinal ligaments, or some combination thereof. This study tested for the presence of a mammal-style nuchal ligament via histological and micro-computed tomography of posterior cervical hemispinous processes of Apatosaurus and Diplodocus, in addition to examining gross morphological features of the cervical vertebrae …

The Occurence Of Expansive Clay Soils In Illinois And Their Effects On Shallow Lightly Loaded Foundations, Greg James Gollaher

Masters Theses

"The damage caused to shallow foundations and slabs on grade by the shrink-swell activity of clay soils is well documented across the United States. There are local and national resources available that delineate areas that are problematic and areas that are not. These resources paint Illinois as an undemanding foundation environment. However, our experience differs from this. Our experience tells us that damage related to the shrink-swell activity of clay soils is widespread, and commonly severe causing not only cosmetic damage to structures and hard improvements but also affecting the serviceability and longevity of structures. My goal is to accurately …

High Temperature Diffraction From Aerodynamically Levitated Materials, Chris J. Benmore, Stephen K. Wilke, David Lipke, Richard Weber

Materials Science and Engineering Faculty Research & Creative Works

Aerodynamic levitation combined with laser beam heating has become an established technique for studying the structure of materials at ultra-high temperatures and under non-equilibrium conditions. This article briefly highlights some recent technical and scientific advancements in understanding the relationships between a material's behavior and its structure, investigated using diffraction methods. It focuses on three evolving frontiers: sophisticated sample environments for accessing metastable states and reactive chemistries, high-flux photon and neutron probes to reveal atomic structure, and advanced computational modeling frameworks. Free from contamination, containerless processing (levitation) can minimize heterogeneous nucleation at the interface, enabling access to deeply supercooled melts or …

Anisotropic Second-Harmonic Ince-Gaussian Beam Generation Using Nbobr2 Holograms, Jayanta Deka, Xiaodong Yang, Jie Gao

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Ince-Gaussian (IG) modes are a complete and orthogonal set of solutions to the paraxial wave equation in elliptic coordinates representing a continuous transition between Hermite-Gaussian modes and Laguerre-Gaussian modes. Chip-scale platforms to generate IG beams have great significance for various applications, including optical trapping and micromanipulation of particles, optical communication, and quantum optics. On the other hand, materials with high optical anisotropy are crucial for building polarization-sensitive optical devices. In this context, niobium oxide dihalides are a new class of ferroelectric materials exhibiting strong, tailorable, and highly anisotropic second-harmonic generation responses. Here, we report the generation of highly anisotropic second-harmonic …

Supersonic Wind Tunnel Free Stream Turbulence Characterization Using 2-Point Focused Laser Differential Interferometry, Joseph Villarreal, Joshua Gary, Davide Vigano

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Non-intrusive laser-based diagnostics, such as Two-Point Focused Laser Differential Interfer-ometry (2-FLDI), play a crucial role in modern aerodynamic research by enabling simultaneous measurements of density and velocity in compressible flows. A 2-FLDI system has been developed and implemented for the Missouri S&T Supersonic Wind Tunnel to characterize free stream turbulence fluctuations and free stream convective velocity. Design choices that enabled the 2-FLDI to overcome low turbulence to measure free stream velocity are detailed. The free stream velocity measurements are validated against previous particle image velocimetry data, showing good agreement. Analysis of normalized velocities and density-based turbulence intensities found that the …

Analytical And Empirical Data-Driven Risk-Governance Design Across The Different Phases: Creating Informed Policy Adjustments For The Transportation Project Lifecycle, Mariam A. Elazhary

Doctoral Dissertations

"Transportation infrastructure is a critical foundation for economic productivity, yet agencies still face challenges in translating the expanding transportation datasets into defensible, phase-specific risk-governance tools. This dissertation addresses this gap by developing analytical and empirical, data-driven approaches to support risk governance across the transportation project lifecycle. Module 1 uses a panel model with bid-letting data to examine how out-of-state contractor participation affects pre-award competition and to derive entry-governance rules. Module 2 analyzes nonfatal injury data through iterative multiple linear regression and fatality data through association-rule change mining to identify multi-factor safety-risk configurations and develop adaptive safety-governance provisions. Module 3 develops …

Re-Crosslinkable Hyper-Branched Polymer Gels Based On A Transamidation Reaction, Tao Song, Baojun Bai, Thomas P. Schuman

Patents

The present invention generally relates to the field of conformance control in oil fields, particularly to a re-crosslinkable preformed particle gel system, and composition thereof. The composition of the re-crosslinkable preformed particle gel system contains monomers, crosslinkers, a polymer matrix, and additives. Components in the composition for re-crosslinkable preformed particle gel in the present invention have excellent compatibility with each other, and the obtained gel has excellent long term high-temperature resistance property. Different from prior products, in the recrosslinkable preformed particle gel compositions according to embodiments of the present invention, the components that are used to re-crosslink the particle gels …

Super-Resolution Learning Inspired Spectral-Spatial Correlation Network For Hyperspectral Target Detection, Jiaping Zhong, Yunsong Li, Jianxin Li, Yanzi Shi, Weiying Xie, Paolo Gamba

Research outputs 2022 to 2026

Hyperspectral target detection (HTD) aims at extracting targets from complex backgrounds while overcoming noise interference. Existing deep learning models for HTD usually suffer from low spatial resolution and unitary representation, especially in space-borne platforms. Super-resolution, as a critical technology to enhance the spatial details, could effectively address the aforementioned issue. To make super-resolution absolutely pose positive effects on target detection, this paper proposes an end-to-end novel super-resolution learning inspired spectral-spatial correlation network for hyperspectral target detection (SR-HTD) from the perspective of spatial and spectral regularization to achieve high-precision detection. Specifically, we designed a Spatial Correlation Aggregation (SCA) module inspired by …

Csr Disclosure In Family-Controlled And Politically Connected Firms: Do Audit Committees Matter?, Md Harun Ur Rashid, Habib, Rashid Zaman

Research outputs 2022 to 2026

Purpose – This study aims to investigate whether audit committees shape the corporate social responsibility (CSR) disclosure practices of family-controlled and politically connected firms. Specifically, this study examines the extent to which audit committees mitigate the tendency of these firms to withhold CSR information and enhance transparency in an emerging market context. Design/methodology/approach – This study analyses 1, 108 firm-year observations from 140 non-financial firms listed on the Dhaka Stock Exchange over the period 2013–2023. To examine how family control, political connections and audit committees influence CSR disclosure. This study estimates several multivariate regression models. In addition, to strengthen causal …

Effect Of Caffeine Ingestion On Cycling Performance: A Systematic Review And Meta-Analysis, Jinyan Wu, Kai Xu, Mingyue Yin, Xianming Ding, Tong Wang, Qiubo Zhang, Xiaowei Wu, Ningkun Xiao

Research outputs 2022 to 2026

This study aimed to determine the effects of acute caffeine ingestion on cycling performance through a systematic review and meta-analysis, while also exploring the moderating roles of caffeine dosage, training status, and athlete age. A comprehensive search was conducted across five databases, yielding 20 eligible studies with a total of 226 participants. A three-level mixed-effects model was applied to pool main effects on cycling time trial performance, mean power output, mean heart rate, and ratings of perceived exertion (RPE). Subgroup analyses and meta-regression were performed to examine potential moderators. Caffeine intake significantly reduced cycling completion time (SMD = −0.36, 95% …

The Effectiveness Of 3d Printing Project-Based Learning In Developing Future Skills And Academic Passion Among 10th Grade Students In Physics, Asma Abdullah Alshabnuti, Salim Khamis Al Harmali, Sulaiman Mohammed Al-Balushi

Journal of Educational and Psychological Studies

The study aimed to explore the effectiveness of 3D Printing Project-based Learning in developing future skills, according to the Omani Future Skills Framework, and academic passion among 10th-grade students in physics in the Sultanate of Oman. A quasi-experimental research design was used, with a control and experimental group. The sample consisted of (114) male and female students. The Study instruments were the Future Skills Classroom Observation and the Academic Passion Scale, to gather data. Findings showed statistically significant differences in favor of the experimental group in most of future skills, except in flexibility and adaptation skill. The effect size of …

Advancing Management Strategies For Airport Infrastructure Development: A Holistic Project Delivery And Contractual Perspective, Ramy Ahmed Anwar Ahmed Khalef

Doctoral Dissertations

The airport sector plays a vital role in the US infrastructure. Neglecting the maintenance and improvement of such critical domain poses serious repercussions. Current initiatives within the aviation sector have fallen short in providing substantial quantitative or qualitative support for comprehensive project and risk management processes. This research fills this knowledge gap. The associated objectives include: (1) identifying a holistic set of Design-Build risk factors and providing associated research recommendations; (2) enhancing the understanding of Design-Build (DB) with respect to Design-Bid-Build (DBB) on key risks impacting schedule/cost performance in airport projects; (3) establishing a risk-based benchmarking framework to evaluate schedule/cost …