Digital Commons Network^™

Helicobacter Pylori And Cancer: What's The Link?, Elettra Merola, Giovanni Mario Pes, David Yates Graham, Maria Pina Dore

Faculty, Staff and Students Publications

Helicobacter pylori (H. pylori) is a human bacterial pathogen that causes one of the most common chronic bacterial infections worldwide. The microorganism has been classified by the International Agency for Research on Cancer as a Group I carcinogen. While the etiological link to gastric cancer is well established, the precise molecular and cellular mechanisms driving this transformation are highly complex and incompletely understood. Fundamentally, the infection results from the chronic presence of acute on chronic gastric mucosal inflammation. H. pylori pathogenicity is increased by bacterial virulence factors including the cytotoxin-associated gene A (CagA) and Vacuolating cytotoxin A (VacA) …

The Crisis Of Theodicy In Wartime Ukraine: From Gottverlassenheit To The Anthropodical Shift, Tetiana Havryliuk, Yuriy Chornomorets, Svitlana Shkil

Occasional Papers on Religion in Eastern Europe

Examination of the crisis of classical theodicy in the context of contemporary warfare, with particular attention to the experience of Russia’s full-scale war against Ukraine. The problem of innocent suffering can no longer be approached solely through speculative attempts to justify the world order or reconcile radical evil with divine providence. Methodologically, the study combines hermeneutic, phenomenological, and comparative-conceptual analysis. It reconstructs a selective genealogy of Gottverlassenheit from Martin Luther’s Theologia Crucis through Dietrich Bonhoeffer and Jürgen Moltmann, brings this tradition into dialogue with contemporary moral anti-theodicy, and examines Ukrainian philosophical and religious reflections shaped by wartime experience. The article’s …

Religious Norms In The Mechanisms Of Legal Regulation Of Freedom Of Conscience In Modern States, Mykola Lahodych

Occasional Papers on Religion in Eastern Europe

This article is devoted to role of religious norms in the legal regulation of freedom of conscience, with a special focus on the institutional interaction in modern democratic societies between religious organizations and the state, particularly in Central and Eastern Europe. The extant scholarly literature has addressed first and foremost the constitutional guarantees of religious freedom and church autonomy. However, less attention has been devoted to the institutional mechanisms through which religious norms operate within public administration. The study utilizes comparative legal analysis, institutional analysis, discourse analysis of official church documents and qualitative analysis of 28 judicial and institutional cases …

Early Drowsiness Detection Via Second-Order Derivative Analysis Of Heart Rate Variability: A Non-Contact Ecg Approach With Machine Learning, Fabrice Vaussenat, Abhiroop Bhattacharya, Julie Payette, Alireza Saidi, Victor Bellemin, Geordi-Gabriel Renaud-Dumoulin, Sylvain G. Cloutier, Ghislain Gagnon

Études primaires

Drowsy driving contributes to roughly 20% of traffic fatalities, yet most detection systems rely on behavioral cues that appear only after impairment has set in. Here we ask whether first and second derivatives of heart rate variability (HRV) can detect pre-crash states earlier than conventional approaches. Twenty-five participants completed 49 driving simulator sessions while we recorded cardiac activity through capacitive ECG electrodes embedded in the seat backrest—a non-contact method that avoids the privacy concerns of camera-based monitoring. To prevent circular evaluation, ground truth labels were based solely on crash proximity rather than HRV-derived scores. The combined HRV feature set (conventional …

Le Parcours Des Travailleurs Immigrants Blessés Et Son Incidence Sur L’Alliance Thérapeutique : Une Étude De Cas Longitudinale En Contexte De Réadaptation Au Travail Au Québec, Maude Arsenault, Jessica Dubé, Daniel Côté

Études primaires

Cette étude explore l’incidence du parcours prélésionnel des travailleuses et travailleurs immigrants (TI) blessés sur l’alliance thérapeutique (AT) en réadaptation au travail. À partir d’une ethnographie longitudinale menée dans une clinique québécoise, sept trajectoires ont été analysées selon leurs dimensions migratoires, socioprofessionnelles et linguistiques. Les résultats montrent que le déclassement professionnel, la précarité de l’emploi, les barrières linguistiques et les expériences de racisme fragilisent la construction du lien de confiance et la définition partagée des objectifs de retour au travail. Lorsque l’emploi prélésionnel est perçu comme transitoire ou inadéquat, l’obligation institutionnelle d’y retourner crée une rupture symbolique qui entre en …

Occupational Exposure To Pesticides Increases The Risk Of Amyotrophyc Lateral Sclerosis: A Systematic Review And Meta-Analysis, France Labrèche, Pamela Prudhomme, Maryse Gagnon, Nicolas Dupré, Sabrina Gravel

Études primaires

Objective To systematically review the evidence on the association between occupational exposure to pesticides and the risk of amyotrophic lateral sclerosis (ALS).

Methods A systematic search, conducted in eight bibliographic databases for publications between 1990 and 2025, identified observational studies estimating the risk of ALS after occupational pesticide exposure. Study quality was assessed using the WHO Risk of Bias (RoB) assessment instrument for systematic reviews, with the ROBINS-E (RoB in non-randomised studies of exposure) tool domains of bias. Pooled risk estimates were produced using random-effects models with restricted maximum likelihood, heterogeneity was assessed with I² statistics, and meta-regressions and publication …

Computer Vision-Based Collision Prevention In Construction: Bridging Academic Advances And Industrial Requirements, Marwa Ziadia, François Gauthier, Damien Burlet-Vienney

Études primaires

Computer vision (CV) technologies have emerged as promising tools for real-time collision risk management. This paper examines CV-based collision-prevention systems from academic and industrial perspectives with a focus on identifying technical and implementation challenges affecting their deployment on construction sites. A scoping review of 158 publications was conducted, alongside an assessment of commercial CV-based collision-prevention systems currently used in construction. The analysis focused on five key functions: object detection, distance measurement and proximity estimation, tracking, worker re-identification (ReID), and deployment robustness. Academic studies demonstrate substantial progress in detection accuracy, real-time processing, trajectory tracking, and predictive risk assessment through deep learning …

Discipline With Due Process: Constitutional Safeguards For Student Speech After Plaintiff A, Sarah Stich

Missouri Law Review

When fifteen-year-old Louie posted a TikTok video criticizing his school’s disciplinary policies from his bedroom, he faced a month-long suspension despite having no notice of which policies he had violated. Across the country, Kaitlin shared a Snapchat criticizing her chemistry teacher with friends at a local coffee shop and faced expulsion with minimal opportunity to explain the context. In both cases, students received limited procedural protections before suffering severe academic consequences.

Endogenous Processes Underlying Clock-Like Mutational Signatures, Teresa Druck, Rami I Aqeilan, C Marcelo Aldaz, Nicola Zanesi, Kay Huebner

Faculty, Staff and Student Publications

Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging and present in normal tissues. SBS1 results from cytosine demethylation, whereas SBS5 and SBS40 arise from unknown endogenous mechanisms. We hypothesized that loss of fragile‐site genes drives these two signatures. FHIT, located at FRA3B, is frequently deleted in cancers, and Fhit‐deficient mouse tissues exhibit a mutation profile resembling human SBS5. Data mining of …

Blood Flow Regulates Metabolism In Hematopoietic Development, Pamela L Wenzel

Faculty, Staff and Student Publications

Blood flow modifies oxygen availability and biomechanical forces within the vasculature of the embryo as the hematopoietic system develops. The aorta-gonad-mesonephros (AGM) envelops the largest artery in the body and is a critical site for the emergence of hematopoietic stem cells (HSCs). Herein, I discuss the role of hypoxia-inducible factors (HIFs) and force as determinants of metabolism and fate determination. To address the effects of blood flow on hematopoietic development, I employ mouse embryo models and biomimetic culture. Real-time cell metabolic analyses show that oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) are altered by flow in cultures of …

Host Modulation Therapy In Periodontitis: From Established Therapies To Emerging Technologies, Aonjittra Phanrungsuwan, Jiaqi Huang, Neeraja Dharmaraj, Alejandra Cobos Perez, Omid Veiseh, Simon Young, Chun-Teh Lee

Faculty, Staff and Student Publications

Periodontitis is a biofilm-induced chronic inflammatory disease, characterized by gingival inflammation and alveolar bone loss. According to a national survey, approximately half of the U.S. adults are affected by periodontal disease. To effectively prevent and treat periodontitis, it is essential to address its underlying causes. The primary etiological factors include polymicrobial synergy and dysbiosis of the oral microbiota, and a dysregulated immune response. The standard therapeutic approach, mechanical removal of biofilm through debridement, sometimes demonstrates limited efficacy, particularly in cases of severe periodontitis, which may require adjunctive or additional therapy. Emerging evidence indicates that periodontal tissue destruction is initiated by …

Serum Protein Signatures For Breast Cancer Detection In Treatment-Naïve African American Women Using Integrated Proteomics And Pattern Analysis, Padma Tadi Uppala, Elmer Rivera, Hyun J. Kwon, Sharon S. Lum

Faculty Publications

Breast cancer is the leading cause of cancer-related mortality in African American (AA) women. In this study we evaluated the serum proteomic profile of AA women with breast cancer using an integrated proteomic framework with multivariate pattern analysis. Using 2D-DIGE, thousands of serum protein spots were detected across 33 gels; 46 spots met criteria for presence, statistical significance, and differential expression. Proteins from the spots were identified by MALDI-TOF/TOF and matched in curated databases, highlighting serum biomarkers including ceruloplasmin, alpha-2-macroglobulin, complement component C3 and C6, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein and haptoglobin-related protein. LC-MS/MS analysis revealed 163 differentiating peptides after imputing and …

Prophetic Preaching As A Tool For Social Justice, Trevor A. O'Reggio

Faculty Publications

No abstract provided.

Evolving Molecular Subtypes Of Gastric Cancer: From Past Classifications To Present Consensus And Future Directions For Precision Therapy, Ju-Seog Lee

Faculty, Staff and Student Publications

Gastric cancer is a biologically heterogeneous disease. The advent of high-throughput multi-omic technologies has revolutionized our understanding of gastric cancer by deconstructing this heterogeneous entity into distinct and more homogeneous molecular subtypes. Early classifications based on gene expression, methylation, and histology have laid the groundwork for multi-omic frameworks proposed by The Cancer Genome Atlas and Asian Cancer Research Group, which established the foundation of modern molecular taxonomy. Subsequent integrative efforts, particularly the Consensus Genomic Subtypes (Super 6) model, have unified this collected information into clinically relevant subtypes that bridge prognostic stratification with treatment strategies. Established biomarkers such as human epidermal …

Nsd2 Inhibitors Rewire Chromatin To Treat Lung And Pancreatic Cancers, Jinho Jeong, Simone Hausmann, Hanyang Dong, Kacper Szczepski, Natasha M Flores, Andy Garcia Gonzalez, Liyang Shi, Xiaoyin Lu, Joanna Lempiäinen, Moritz Jakab, Liyong Zeng, Tourkian Chasan, Eric Bareke, Rui Dong, Emma Carlson, Reinnier Padilla, Dylan Husmann, Julia Thompson, Gerry A Shipman, Emily Zahn, Courtney A Barnes, Laiba F Khan, Liz Marie Albertorio-Sáez, Eva Brill, Vishnu Udayakumar Sunita Kumary, Matthew R Marunde, Danielle N Maryanski, Cheryl C Szany, Bryan J Venters, Carolina Lin Windham, Michal Eligiusz Nowakowski, Iwona Czaban, Mariusz Jaremko, Michael-Christopher Keogh, Kang Le, Michael J Soth, Benjamin A Garcia, Łukasz Jaremko, Jacek Majewski, Pawel K Mazur, Or Gozani

Faculty, Staff and Student Publications

NSD2 catalyses the epigenetic modification H3K36me2 (refs. 1,2) and is a candidate convergent downstream effector of oncogenic signalling in diverse malignancies3–5. However, it remains unclear whether the enzymatic activity of NSD2 is therapeutically targetable. Here we characterize a series of clinical-grade small-molecule catalytic NSD2 inhibitors (NSD2i) and show that the pharmacological targeting of NSD2 constitutes an epigenetic dependency with broad therapeutic efficacy in KRAS-driven preclinical cancer models. NSD2i inhibits NSD2 with single-digit nanomolar half-maximal inhibitory concentration potency and high selectivity over related methyltransferases. Structural analyses reveal that the specificity of NSD2i for NSD2 …

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell

Faculty, Staff and Student Publications

Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and …

Review Of 'The Royal Musical Association: Creating Scholars, Advancing Research' By Leanne Langley, Nuria Bonet

School of Art, Design and Architecture

No abstract provided.

Presence And Characteristics Of Plastics And Microplastics On The Seabed Of The Western English Channel, Faye Read, Andrew Turner

School of Geography, Earth and Environmental Sciences

Little is known about the presence, distribution, origins and characteristics of plastic litter and microplastics on the ocean floor. In this study, plastics trawled from the bed of the western English Channel have been categorised and analysed by a variety of optical and spectroscopic techniques. A total of 90 plastic samples were classified, in descending order of abundance, as food-drink packaging, unknown, homeware, military and fishing. Most samples showed varying degrees of weathering (e.g., discolouration, distortion, cracking, fragmentation) and were visibly fouled by calcareous deposits. The majority of samples were constructed of polymers of negative buoyancy (e.g., polyamides, polyethylene terephthalate …

Planetarity And Relation: Ecology As Method, Ashish Ghadiali

School of Art, Design and Architecture Theses

The List of Works submitted comprises research through film, text, exhibition, performance and policy engagement, developed during a three-year period from 2021 to 2024 in the site-specific location of Southwest England. This multi-modal and interdisciplinary practice is framed in response to the question of how art and cultural strategy can, in the contexts of climate breakdown and global racial inequity, be conceived of as agency for environmental justice. In this integrative summary, I present a theoretical framework where ecology, in response to conditions of environmental crisis, is understood not only as a subject of inquiry but also as method. In …

Feminism, Domestic Abuse And The Singer-Songwriter, Kathryn Ferguson

School of Art, Design and Architecture Theses

This project explores how feminism and domestic abuse can be articulatedthrough songwriting. Research in music therapy, sociology and popular musicincreasingly speaks to the value of songwriting as a tool for personal andcommunity empowerment, but there is space to actively use songwriting toexplore feminist issues independently of the traditional commercial context ofpopular music. Existing feminist music has been deemed as at its mostsuccessful when it is linked clearly to social change in our communities(Greene, 2017, p.8). Modern popular feminist songwriting has been criticised fornot going far enough in deconstructing systemic patterns of patriarchy (Tong,2024, p.9). Considering this, engaging with academic research …

Translating Human Emotion Into Music: A Multimodal Machine-Learning Framework Linking Movement, Facial Expression, And Real-Time Generative Composition, Martin Mc Corry

School of Art, Design and Architecture Theses

This thesis investigates whether embodied human expression—captured through facial and full-body motion—can be translated into musically coherent behaviour using time-series machine learning and real-time generative systems. The project develops and evaluates a multimodal framework that links participant-specific emotion inference to an interpretable, artist-configurable generative music system.Across two sensing modalities, personalised BiLSTM-based models achieved ~99%window-level validation accuracy within participants under a strict leak-free protocol, with no evidence of overfitting. These models were deployed within a low-latency real-time inference system. The research introduces a structured translation layer comprising a consensus mapping matrix and a tiered control architecture, mediating between probabilistic inference and …

Analysis Of Volatility Between Macroeconomic Variables And Busan Port Cargo Throughput According To Global Risks, Sang Ho Cho

Plymouth Business School Theses

This study investigates how container (BPC) and non-container (BPB) cargo throughput at Busan Port responds to structural shocks in global and domestic macroeconomic variables, and how their relative importance changes over time. The selection of variables was based on a combination of a Systematic Literature Review (SLR) and semi-structured interviews (SSI). The econometric analysis applied a stepwise framework, employing cumulative Impulse Response Functions (IRF) and Forecast Error Variance Decomposition (FEVD) based on Vector Error Correction Model (VECM) estimations, as well as Historical Decomposition (HD) for specific crisis periods. While IRF and FEVD were used to capture dynamic properties under general …

Predicting Smes’ Credit Risk Using Artificial Intelligence Applications: Evidence From The Uk Smes, Fatima Badi

Plymouth Business School Theses

Financial distress is a state in which businesses struggle to pay their debts, whichfrequently results in bankruptcy or company failure. Small and medium-sizedenterprises are an essential part of economies, making substantial contributions toproductivity growth, innovation and employment. Evaluating financial health iscrucial to preventing possible hardship, reducing systemic risks and ensuring long-term stability because of its significant contribution to national and internationaleconomies.Bankruptcy prediction models play a critical role as early warning systems that enablefirms, lenders and policymakers to identify financial distress at an early stage and takecorrective action before failure becomes inevitable. These warning indicators mayresult from internal issues, such as …

In Trust We Trust: Role Of Trust In Business Negotiations In The Context Of Switzerland As A High-Trust Country, Aksana Babich

Plymouth Business School Theses

The present research examines the role of trust in business negotiations in the context of Switzerland, a high-trust country. Using a qualitative, practitioner-oriented design grounded in template analysis, the research draws on semi-structured interviews with thirty professionals from diverse sectors of the economy of the canton of Geneva. Switzerland’s high-trust environment provides an empirical context in which trust mechanisms are particularly visible and operational.The research advances conceptual, empirical and methodological knowledge of trust in negotiations. Conceptually, it clarifies the meaning of trust, demonstrating that trust is not a one-dimensional construct centred on risk and vulnerability, but a multifaceted moral value …

Examining The Nexus Between Social Capital, Value Co-Creation And Entrepreneurship In Nigeria: Assessing The Moderating Role Of Social Media In A Resource-Constrained Context, Ben Omoruyi

Plymouth Business School Theses

This research provides a transformative perspective on how Social Capital (SC), Value Co creation (VCC), and Social Media (SM) interact to shape Entrepreneurial Outcomes (EOs) in institutionally weak, resource-constrained contexts. Positioned within a positivist ontology and grounded in Social Capital Theory, the research reconceptualises SC not as a passive stock of relationships but as a dynamic entrepreneurial capability, strategically mobilised to access resources, legitimacy, and opportunities. Focusing on Nigeria’s fashion industry, a sector characterised by informality, weak institutions, and heavy network reliance, the study adopts a quantitative, deductive design. Data from a cross-sectional survey of 580 entrepreneurs aged 18–55, in …

Driving Venture Success: A Collaborative Framework For The Consumer Goods Industry, Mohammad Alhusaeini Mohammad

Plymouth Business School Theses

This thesis addresses the persistent gap between the strategic promise of external corporate venturing (ECV) and its frequently disappointing outcomes in the global consumer goods industry, with a specific focus on the non-durable consumer goods sub‑sector. Despite ECV’s recognised importance for innovation—particularly in a sector characterised by rapid consumer preference shifts, tight margins, and complex supply chains—collaborations with external start-ups are often undermined by cultural misalignment, strategic ambiguity, and ineffective performance measurement. Through an abductive, mixed-methods research design within an interpretivist paradigm—integrating archival analysis, six in-depth corporate case studies (P&G, PepsiCo, Unilever, Danone, Henkel, and L’Oréal), and 32 interviews with …

Exploring The Views Of Children With Cerebral Palsy, Their Parents And Physiotherapists On Participating In A Feasibility Randomised Controlled Trial Testing An Exergaming Device: A Qualitative Study, Rachel Rapson, Jos M. Latour, Jonathan Marsden, Bernie Carter

School of Nursing and Midwifery

Background: This study aimed to understand the experiences and views of children with cerebral palsy, their parents and physiotherapists participating in the ACCEPT feasibility randomised controlled trial, which explored a 10-week physiotherapy intervention using an interactive gaming training device. Design: Qualitative methods included semi-structured interviews, e-diary and photographs. Nine parent–child dyads and three physiotherapists participated. Children were aged between 7 and 16 years; four had co-existing additional needs. Interviews were transcribed. Reflexive thematic analysis was used. Results: Five themes covered the breadth of participants’ experiences: (1) Fitting in therapy; (2) Motivation; (3) New opportunities; (4) Physiotherapists out of their comfort …

A Taxonomy And Empirical Evaluation Of Webassembly Runtimes For Performance And Energy Across Machine Learning And Arithmetic Workloads, Sallar Khan, Tania Malik, Khalid Hasanov

Research Outputs: 2025-Present

WebAssembly (Wasm) has emerged as a lightweight, portable, and secure execution environment beyond the browser, with growing adoption in data-intensive, machine learning, and performance-sensitive workloads. However, the runtime ecosystem remains fragmented, and a systems-level understanding of how runtime design affects performance and energy efficiency is still lacking. This paper makes two contributions. First, it presents a taxonomy of modern WebAssembly runtimes that classifies the runtime landscape by execution model, compilation strategy, integration style, and systemslevel capabilities. Second, it provides an empirical evaluation of 13WASI-compatible runtimes and a native baseline across eight benchmarks, namely, four machine learning workloads (Logistic Regression, K-Means, …

Ai For Prognosis Among People Living With Hiv: Protocol For A Systematic Review And Meta-Analysis, Degninou Yehadji, Markus Hofmann, Petros Isaakidis, Smaila Alidou, Olushina Ayo Junior Ale, Kofivi Mawouko Yena, Kodjo Guidigan, Geraldine Gray, Nadjime Pindra, Gayo Diallo

Research Outputs: 2025-Present

Background: Advanced HIV disease remains a major global health concern, with nearly 40.8 million people living with HIV as of 2024. Antiretroviral therapy has improved outcomes, but its success depends on timely intervention, adherence, and retention in care. AI, including machine learning and deep learning, offers promising tools for prognostic modeling that could support clinical decision-making and personalized treatment. Existing syntheses, however, have been largely narrative and have not systematically evaluated the performance, risk of bias, reporting quality, or clinical readiness of AI-based prognostic models, leaving a critical gap in understanding their validity and applicability. Objective: This study aims to …

Best Practice Guidelines For Professional Carers In Emergency Seizure Medication, Rohit Shankar

Peninsula Medical School

No abstract provided.