Digital Commons Network^™

Beyond The Evidence: The Cervical Collar As Cultural Artefact, Tim Nutbeam

Peninsula Medical School

Background: Cervical collar application remains prevalent in trauma care despite the absence of evidence of neurological benefit from spinal immobilisation. Clinical behaviour in this area has proven resistant to change, and the persistence of the collar requires explanation beyond the evidential debate alone. The fear of cervical injury has origins that predate clinical practice. Neurobiological preparedness theory suggests that threat associations linked to survival-relevant stimuli are more rapidly acquired and more durably maintained than other learned fears; the cervical region is a plausible candidate for this form of prepared response. This disposition has been reinforced by centuries of cultural practice: …

Decoding Immunotherapy Response Through Computational Modeling, Bingrui Li, Ruihan Luo, Kexin Huang, Jiajia Liu, Weiling Zhao, Xiaobo Zhou

Faculty, Staff and Student Publications

Immunotherapy has seen success in treating patients with cancer, but variable responses underscore the need for effective patient stratification and therapy planning. Computational tools integrating multi-omics, imaging and machine learning have advanced, yet reliable personalized predictions remain challenging. This review analyzes the field through four converging paradigms: classical machine learning, deep learning, graph and network modeling, and mechanistic systems biology. We examine the evolution from correlational features to representation learning, relational inference, and causal simulation of tumor-immune dynamics, highlighting the shift towards multi-modal fusion and interpretable, clinically deployable models. By providing an integrated review of these computational tools, we hope …

Dietary Manipulations Of The Undernourished Infant Microbiome, Cyrus Zhou

Arts & Sciences Graduate Student Theses and Dissertations

Today, undernutrition affects approximately 150 million children worldwide. During the first two years of life, the healthy gut microbial community undergoes a series of predictable developmental transitions. These transitions are delayed in undernourished children resulting in microbiota “immaturity.” In a foundational study, immature gut microbial communities from undernourished children and normally developing communities from chronologically age-matched healthy children living in the same area were transplanted into groups of germ-free mice consuming the same diet – one representative of what consumed by the study population. Compared mice with a mature gut microbiome, mice with an immature gut microbiome had impaired weight …

Essays On Empirical Research Of Education, Criminal And Decision, Hsuan-Hua Huang

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation consists of three essays in applied microeconomics, examining how subjective beliefs, institutional designs, and policy incentives shape critical life-cycle decisions in education and public safety. The first chapter investigates how students form beliefs about their academic ability and how the misalignment between perceived and benchmark ability shapes high-stakes educational sorting. Using longitudinal data from Taiwan, I show that these ability gaps systematically predict school and track choices. By developing a model of utility maximization under perceived ability, the results highlight that subjective beliefs, rather than objective scores alone, are central to educational outcomes and potential mismatches in school …

Impact Of Living Shorelines On Coastal Morphology And Sedimentology, Sydney Garber

Electronic Theses and Dissertations 2020 - Present

Living shorelines, or nature-based solutions, have emerged as a preferred approach to coastal restoration, but have not been well studied or monitored postimplementation. This project evaluated the efficacy of living shorelines in protecting and stabilizing coastal morphology in Palm Beach County’s Lake Worth Lagoon. The study assessed surface and subsurface sedimentology, short-term water-level variability, and morphological change at two living shoreline areas of Jewell Steinhardt Cove and Snook Islands Natural Area. Each shoreline area has different breakwater designs aimed at stabilizing the shoreline with recruitment of oysters and mangroves in the Lake Worth Lagoon. Overall, seasonal morphology and sediment data …

Single-Nucleus Brain Transcriptomics Reveals Microglia Dysfunction In Multiple System Atrophy, Rasmus Rydbirk, Frederik Nørby Friis Sørensen, Jonas Folke, Henriette Haukedal, Andrea Asenjo Martinez, Irene Lisa Vargas, Simone Mcgarry, Oline Chantell Hollmann, Camila Gherardelli, Sofia Sepulveda, Adam T Szafran, Michael A Mancini, Sanne Simone Kaalund, Tomasz Brudek, Lisette Salvesen, Sara Bech, Justyna Okarmus, Peter Kharchenko, Morten Meyer, Claudio Soto, Kristine Freude, Abhisek Mukherjee, Susana Aznar, Konstantin Khodosevich

Faculty, Staff and Student Publications

Multiple system atrophy (MSA) is a rare, age-related neurodegenerative disease that shares clinical and pathological features with Parkinson's disease (PD) but presents a more devastating disease course. To elucidate the distinct cellular pathophysiology, we performed single-nucleus RNA sequencing on postmortem striatal brain tissue from 7 MSA and 12 PD patients, and 10 non-neurological cases. Here, we show significant compositional differences in astroglia and microglia subtypes, while oligodendroglia and neurons are comparable. PD brains show abundant microglia expressing MHC class II HLA haplotypes, indicative of a proinflammatory state, alongside more homeostatic astrocytes. In contrast, MSA lack activated microglia but has more …

2026-04-15 Redhawk Dining Announces Spring Changes, Maya Deguzman

The Spectator Online

No abstract provided.

Ellagic Acid Reduces Inulin's Adverse Effects: A Combined Approach To Enhance Therapeutic Potential In Nonalcoholic Steatohepatitis, Tharani Senavirathna, Shafaei, Ricky Lareu, Lois Balmer

Research outputs 2022 to 2026

This mouse study investigates the efficacy of ellagic acid (EA), a potent antioxidant in fruits and nuts, and inulin, a prebiotic known for gut microbiota benefits, in nonalcoholic steatohepatitis (NASH). A Western-style diet (WD) was used to induce NASH in C57BL/6J male mice for 16 weeks. Mice then received EA (100 mg/kg/day, oral gavage, 5 days/week) and/or 5% inulin (w/w in diet) for 12 weeks while continuing WD. Inulin increased energy intake and trended toward higher body weight and fasting glucose. EA reduced liver weights and restored the liver-to-body weight ratio. EA and inulin combined significantly reduced steatosis and hepatocyte …

High Germinability Can Facilitate Recovery Of Adelia Vaseyi (Euphorbiaceae), An Imperiled Tamaulipan Thornscrub Shrub, Saroj Dhakal, Bashira Chowdhury, Alejandro Fierro-Cabo

School of Earth, Environmental, & Marine Sciences Faculty Publications

While critical to maintaining dryland biodiversity and drought resilience, reforestation has been limited in subtropical dry forests because of knowledge gaps in seed biology that must be filled to upscale seedling production and ensure recovery of imperiled endemic plants. We characterized seed germination, dormancy, and storage needs for Adelia vaseyi, a threatened endemic shrub commonly included in planting mixes to restore Tamaulipan thornscrub, an imperiled subtropical forest spanning South Texas and Northeastern Mexico. We found A. vaseyi seeds have high germinability (82.0%) and a short mean germination time (3.04 ± 0.08 days). A delia vaseyi seed does not appear …

What It Takes To Solve The Origins Of Life: An Integrated Review. Part 2: Theoretical Methods And Emerging Trends, Silke Asche, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, Zheng Peng, Avinash Vicholous Dass, Eloi Camprubi

School of Integrative Biological & Chemical Sciences Faculty Publications

The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Understanding the processes relevant to the OoL demands theoretical frameworks that can connect processes across scales, from microscopic dynamics to emergent levels of organization. While experimental studies generate a wealth of data, theoretical and computational approaches provide the structure necessary to interpret and generalize these findings. In Part 1, we examined the most widely used experimental techniques in the field. Here, we focus on the mathematical, physical, and computational techniques used to model phenomena relevant to life’s origin(s). We discuss …

Emotional Awareness And Resilience In Adolescents, Emilie Zimmerman

Master's Theses (2009 -)

Adolescent trauma exposure is prevalent and associated with a range of negative developmental outcomes. However, some youth demonstrate resilience. Emotional awareness, a foundational component of emotion regulation, may play a role in promoting adaptive functioning following adversity, though its contribution to resilience in trauma-exposed adolescents remains unclear. The present study examined whether emotional awareness is associated with multiple domains of resilience including prosocial behavior, self-efficacy to handle conflict, perceived resilience, and emotional and conduct problems, after accounting for trauma exposure. Participants were 36 adolescents enrolled in a support program for at-risk youth. Data were obtained from youth-report measures of trauma …

Lateral Minimally Invasive Si Joint Fusion Following Adult Spinal Deformity: A Case-Report And Literature Review, Basel Musmar, Hassan Saad, Joshua Pelta-Heller

Department of Neurosurgery Faculty Papers

This case report describes lateral minimally invasive sacroiliac (SI) joint fusion for SI joint–mediated pain in a patient with a history of adult spinal deformity surgery. A 48-year-old woman with multiple medical comorbidities previously underwent long thoracolumbar fusion. She subsequently had L4-S1 anterior lumbar interbody fusion and posterior L4-pelvis instrumentation in 2010. Following a ground-level fall in 05/2021, she developed new left-sided hip and sacroiliac pain with intermittent left lower-extremity numbness. Radiographs demonstrated mild hip osteoarthritis and sacroiliac joint sclerosis; spine imaging revealed discontinuity of the right iliac fixation rod without acute fracture. MRI of the hip showed bilateral sacroiliitis …

Brown Pelican (Pelecanus Occidentalis) Groundings On A Four-Lane Divided Highway In South Texas: A Comparative Study Using Citizen Science, Bradley Evan Beer, Kevin W. Ryer, Md. Saydur Rahman, John H. Young Jr., Richard J. Kline

School of Integrative Biological & Chemical Sciences Faculty Publications

The population of the once-endangered brown pelican (Pelecanus occidentalis) has increased over the past several decades and is now considered fully recovered. However, in south Texas, the combined effects of weather patterns, transportation infrastructure, and brown pelican biology have led to road mortalities on State Highway 48 (SH 48) at the Carl “Joe” Gayman Bridge. To mitigate these mortalities, the Texas Department of Transportation modified traffic barriers on SH 48. We aimed to examine the effect of the barrier change and determine which weather variables influence brown pelican groundings on SH 48. Citizen scientists monitored sections of SH …

Uniqueness And Nonlinear Stability Of Positive Entire Solutions In Parabolic-Parabolic Chemotaxis Models With Logistic Source On Bounded Heterogeneous Environments, Tahir Bachar Issa

Faculty Research, Scholarly, and Creative Activity

This paper studies the asymptotic behavior of solutions of the parabolic-parabolic chemotaxis model with logistic-type sources in heterogeneous bounded domains: (formula present) We find parameter regions in which the system has a unique positive entire solution, which is globally asymptotically stable. More precisely, under suitable assumptions on the model’s parameters, the system has a unique positive entire solution (u∗(t, x), v∗(t, x)) such that for any u0 ∈ C⁰(Ω̅), v0 ∈ W^1,∞(Ω̅) with u0, v0 ≥ 0 and u0 ≢ 0, the global classical solution (u(t, x; t0, u0, v0), v(t, x; t0, u0, v0)) of …

The Influence Of The Timing Of Definitive Restoration Placement After Root Canal Completion: A 22-Year Retrospective Study, Shikha Gupta

Master's Theses (2009 -)

Objective: To evaluate how the time interval between root canal obturation and the placement of a definitive restoration impacts the incidence of tooth failure, defined as non-surgical retreatment, apical surgery, or extraction. Methods: This 22-year-retrospective cohort study utilized electronic health records from the Marquette University School of Dentistry (MUSoD) axiUm database, analyzing 11,002 teeth treated between 2004 and 2026. Inclusion criteria required patients to be at least 18 years of age, categorized as established patients of record, with all non-surgical root canal treatments (NSRCT) meeting the 2020 AAE quality standards. The interval between obturation and restoration was categorized into seven …

Inflammation- And Resolution-Programmed Myeloid Circuits Govern Therapeutic Resistance In Epithelial And Mesenchymal Triple-Negative Breast Cancer, Liqun Yu, Charlotte Rivas, Fengshuo Liu, Yichao Shen, Ling Wu, Zhan Xu, Yunfeng Ding, Xiaoxin Hao, Weijie Zhang, Hilda L Chan, Jun Liu, Bo Wei, Yang Gao, Luis Becerra-Dominguez, Yi-Hsuan Wu, Siyue Wang, Tobie D Lee, Xuan Li, Xiang Chen, David G Edwards, Xiang H-F Zhang

Faculty, Staff and Students Publications

Single-cell analysis of human triple-negative breast cancer revealed heterogeneous macrophage populations with opposing phenotypes - proinflammatory and proresolution of inflammation. Paradoxically, both subsets accumulated in therapy-refractory residual tumors but showed inverse correlations across patients, suggesting mutually exclusive resistance mechanisms. Inflammatory macrophages localized preferentially to epithelial-like tumors, whereas proresolution macrophages were enriched in mesenchymal-like tumors. Mouse models faithfully recapitulated these patterns. After chemoimmunotherapy, mesenchymal-like tumors expanded proresolution macrophages through phagocytosis/efferocytosis, ω-3 fatty acid uptake, and resolvin production. Macrophage-secreted C1q emerged as a principal antagonist of T cell function by targeting mitochondria and inducing metabolic dysfunction. By contrast, epithelial-like tumors accumulated inflammatory …

Kecenderungan Wanita Menjadi Korban Tindak Pidana Terhadap Kesusilaan, Sumiyanto Sumiyanto

Jurnal Hukum & Pembangunan

Abstract

Effects Of Solvent Type, Storage Time, And Storage Temperature On Free Radical Stability And Concentration In Model Radical Systems And Complex Vegetable Oil Matrices, Rachid Ismail Daboussi

Thesis/ Dissertation Defenses

Free radicals are reactive species with unpaired electrons that occur and form within a range of biological, physical, and chemical systems. These highly reactive entities can interact with each other and/or with other molecules present in a mixture, often leading to significant changes in the system. Control over free radical concentration and free radical reactions is necessary in various fields depending on the aim of the process. For instance, free radical addition reactions play an essential role in the synthesis of polymers, where controlled radical behavior is necessary. However, in the thermal cracking of oil, free radical addition reactions are …

Tenncare's Fiscal Year 23-24 Annual Report, Tennessee. Division Of Tenncare.

TennCare Annual Report

No abstract provided.

Actuarial Review Of The Tenncare And Tenncare Partners Programs (Fy 24), Tennessee. Department Of Human Services.

TennCare Actuarial Report

No abstract provided.

Actuarial Review Of The Tenncare And Tenncare Partners Programs (Fy 25), Tennessee. Department Of Human Services.

TennCare Actuarial Report

No abstract provided.

Dda Annual Report 2024, Tennessee. Commission On Aging & Disability.

Department of Disability & Aging

No abstract provided.

A Computational Assessment Of Halobacterium Salinarum Glutamate Dehydrogenase Enzymes, Maaz Abdalla

Thesis/ Dissertation Defenses

Glutamate dehydrogenase (GDH) is a hexameric enzyme. GDH is involved in several pathways and cellular processes such as oxidation-reduction homeostasis, ammonia metabolism, lipid biosynthesis, insulin and lactate production, and acid-base equilibrium. The main objective of this thesis is to understand the structural and biochemical properties of this enzyme and why some organisms, for e.g., Halobacterium salinarum, have more than one GDH with different coenzyme specificities. The catabolism of glutamate is linked to NAD+-specific GDHs, meanwhile, NADP+-specific GDHs play an anabolic role in ammonia assimilation. Molecular docking and binding free energy calculations were employed followed by long-scale (500 nanoseconds) comparative molecular …

College Student Perceptions Of Death, Shelby Brubaker, Melinda Heinz

INSPIRE Student Research and Engagement Conference

The purpose of this study was to understand college student perceptions of death. Undergraduate students were invited to participate in a focus group about their perceptions of death. Three focus groups were held and a total of nine students participated, all of whom had majors in the social sciences. All participants were women and approximately 55% were non-religious and 55% reported they were spiritual. Braun and Clarke’s reflexive thematic approach was used to code focus group transcriptions. Three themes were identified: 1) Family and Religious Influences: One participant said, “I think it is less of how religion has shaped …

Evaluating Moisture Content , Organic Matter And Mineral Matter In Mangrove Sediments Of The Wouri Estuary, Cameroon, Fama A. Dia

SACAD: Scholarly Activities

Mangroves are important coastal ecosystems that support carbon storage, coastal protection, biodiversity, and sediment dynamics. However, the variability and composition of sediments in the tropical Wouri Estuary (Cameroon) remain poorly understood. This study investigates the relationships between key properties such as moisture content, organic matter, and mineral matter in mangrove sediments of the Wouri Estuary. Three sediment cores were collected from the west (Mungo), central (Koo), and east (Dibamba) flanks of the estuary and analyzed using the Loss on Ignition (LOI) method. Samples were oven-dried at 105°C for 48 hours to determine moisture content and combusted at 550°C for 4 …

Fatal Ochrobactrum Anthropi Bacteremia Following Intravenous Stem Cell Therapy In Immunocompetent Patient, Daler Kudratov, Wendy Martinez, Jonathan Barnett

Central & West Texas and San Antonio GME Research Day 2026

No abstract provided.

Rare Clinical Presentation Of Primary Cutaneous Diffuse Large B-Cell Lymphoma (Pcdlbcl), Germinal Center B-Cell Subtype (Gcb), Confined To The Scalp, Anabel Al Abdallah, Angelo Piazza Ortiz, Joshua Rodriguez, Juan Herrada

Central & West Texas and San Antonio GME Research Day 2026

No abstract provided.

B Cells Enable Autoreactive T Cells To Avoid Suppression., Matthew Funsten, Renee De Pooter, Vineeth Varanasi, Michael Burrows, Katharine Block, Andrey Kuznetsov, David V. Serreze, Haochu Huang, Alexander Chervonsky

Faculty Research 2026

Clinical trials and experimental observations have shown that B cells are essential for development of T cell-mediated organ-specific autoimmunity, although their exact contribution is not clear. As antigen presentation by B cells is focused on antigens cognate to their antigen receptors, we reasoned that B cells would facilitate activation of T effector cells (Teff) with the same antigen specificity but would poorly activate regulatory T cells (Treg) due to insufficient presence of antigen-specific Tregs among polyclonal/multispecific Tregs at the early stages of pathogenesis. At the same time, activation of Teff by autoantigens presented by dendritic cells (DC) would be sensitive …

Race Evasion In White Student Affairs Professionals In Minnesota Higher Education: A Phenomenology, Cindy Boe

Dissertations, Theses, and Projects

Language that includes race-evasive frames is used by White individuals to maintain a status quo wherein White individuals hold greater access to societal power and resources than people of color. Race-evasive frames include abstract liberalism, naturalization, cultural racism, and disconnected power-analysis. In higher education, use of race evasive frames has been primarily documented in White college students and White faculty members. This study addressed in a gap in the literature related to race evasion in White student affairs professionals. Student affairs professionals provide direct support to college students. Scholars have suggested that student affairs professionals carry responsibility for advancing equity …

Tremor Modulation: A Systematic Review Of Resetting By Single-Pulse Transcranial Magnetic Stimulation ​, Handan Uzunçakmak Uyanik, Çağri Mesut Temuçi̇n

Turkish Journal of Medical Sciences

Background/aim: Tremor arises from mechanical, reflex, or central oscillatory mechanisms. Transcranial magnetic stimulation (TMS) can transiently perturb ongoing tremor and enables the quantitative assessment of phase resetting, offering circuit-level insight into tremor types. Although numerous studies have applied TMS-induced resetting, the findings have not been systematically reviewed. This study systematically reviews human studies evaluating TMS-induced tremor resetting across tremor types.

Materials and methods: A systematic search of PubMed and Google Scholar identified human studies using TMS to perturb tremor or rhythmic movement. Search terms included “tremor resetting,” “resetting of tremor,” “tremor phase shift,” “tremor phase reset,” “transcranial magnetic stimulation,” and …