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Developing Training And Streamlining Training Management Process For Smithfield Fire Department Employees In Aha, Naemt, And Aap Certifications, Michael Christopher Popa Ii
Developing Training And Streamlining Training Management Process For Smithfield Fire Department Employees In Aha, Naemt, And Aap Certifications, Michael Christopher Popa Ii
Undergraduate Honors Capstone Projects
The rapid operational expansion of the Smithfield Fire Department and EMS (SFD)—marked by a 300% increase in call volume and a transition to a fully professional, independent paramedic service—exposed critical systemic inefficiencies in clinical preparedness and personnel credentialing. This project addresses the "HALO Paradox," wherein high-acuity, low-occurrence emergencies require expert-level proficiency that cannot be maintained through call volume alone. Historically, the agency relied on fragmented, external continuing education (CE) that incurred high financial costs, lacked equipment standardization, and created administrative bottlenecks during biannual recertification cycles. The central objective of this capstone was to engineer a sustainable, in-house training infrastructure that …
The Hitchhiker's Guide To The Host: Fleas And The History Of Pikas In North America, Josh Pletcher
The Hitchhiker's Guide To The Host: Fleas And The History Of Pikas In North America, Josh Pletcher
All NMU Master's Theses
Parasite phylogenetics can offer windows into the cryptic evolutionary history of hosts, often highlighting events that are not recorded by the phylogenetics of the host. Pikas (small lagomorphs) host a diverse parasite community comprising endoparasites (e.g., coccidians, nematodes, and cestodes) and ectoparasites (e.g., fleas and mites). Phylogenetic analysis of pika endoparasites has revealed pikas evolved in Asia and colonized North America in two waves, and that contact between these two pika lineages allowed parasites to be transferred from one lineage to another and to survive the extinction of their original host. To uncover these cryptic histories, understanding the biogeography of …
Nutrition Teaching Methods In Communities, Emery Fayth Rowles
Nutrition Teaching Methods In Communities, Emery Fayth Rowles
Undergraduate Honors Capstone Projects
Community is a vital part of non-formal education. A sense of, longing for, and responsibility towards community draws individuals to participate in local services and classes. Community has been shown to have positive impacts on learning, self efficacy, and health.
Many of the techniques used in education mirror techniques used in building community—such as the use of small group discussions and cultural sensitivity—but with distinct differences in mindset. Most educational approaches see the acquisition and use of knowledge as the key purpose of the program and evaluate participants on an individual basis. This approach makes sense for programs meant to …
Ccr5 Sulfopeptide Library And O-Glycosylated Amino Acids As Chemical Tools For Probing Chemokine Receptor Recognition, Mostafa Mohammed Mohammed Ali Eldeen
Ccr5 Sulfopeptide Library And O-Glycosylated Amino Acids As Chemical Tools For Probing Chemokine Receptor Recognition, Mostafa Mohammed Mohammed Ali Eldeen
Electronic Theses and Dissertations
Chemokine-receptor interactions play a central role in immune regulation and disease pathogenesis, particularly through CCR5, a receptor engaged by chemokines such as CCL3, CCL4, and CCL5. Post-translational modifications of the CCR5 N-terminus—including tyrosine sulfation at positions 3, 10, 14, and 15, and O-glycosylation at serine 6—critically modulate chemokine recognition and selectivity. However, the impact of specific sulfation patterns on chemokine binding and the synergistic effects of combined sulfation and glycosylation remain incompletely understood. This thesis presents a two-project chemical approach to systematically investigate CCR5 post-translational modifications. In Project 1, a comprehensive 16-member library of CCR5???? sulfopeptides representing all possible combinations …
A Revised Quantifier Variance And Its Implications On Vagueness, Isaac Alexander Huling
A Revised Quantifier Variance And Its Implications On Vagueness, Isaac Alexander Huling
Electronic Theses and Dissertations
This paper argues that the Special Composition Question has no substantive answer, not because compositional talk is empty but because the physical structure it tracks does not have the form that would privilege a unique answer. The argument accepts Sider’s methodological premise that the world must provide structure beyond description if ontological vocabulary is to mean anything, and deploys that apparatus against his specific application of it to composition. Constraint processes among a system’s parts – the forces and interactions that hold rigid bodies together, maintain organisms, bind solar systems – satisfy every condition Lewis required of reference magnets. They …
Landscape Connectivity And Wildlife Access To Water Across An International Border: Barriers And Opportunities For Facilitating Transboundary Movement, Bogdan Chivoiu, Erin L. Koen, Michael J. Osland, Christopher A. Gabler, Jerald T. Garrett, Ernesto Reyes, Stephanie A. Bilodeau, Mitch A. Sternberg, Jude A. Benavides, James Martinez
Landscape Connectivity And Wildlife Access To Water Across An International Border: Barriers And Opportunities For Facilitating Transboundary Movement, Bogdan Chivoiu, Erin L. Koen, Michael J. Osland, Christopher A. Gabler, Jerald T. Garrett, Ernesto Reyes, Stephanie A. Bilodeau, Mitch A. Sternberg, Jude A. Benavides, James Martinez
School of Earth, Environmental, & Marine Sciences Faculty Publications
Rapid global acceleration in the construction of physical barriers along international borders has greatly influenced biodiversity and animal movement. Physical barriers can fragment landscapes, hinder access to essential resources, impact long-distance migrations, and inhibit dispersal and gene flow. The effects of physical barriers on animal movement and landscape connectivity can be exacerbated in dryland environments where access to water is a limiting factor. In recent decades, the construction of border barrier infrastructure has accelerated along the international boundary between the United States and Mexico. Here, we used a landscape connectivity model to investigate the effects of barriers on wildlife access …
Establishing Caenorhabditis Elegans As A Platform For Bioaccumulation And Selectivity Screening Of Anthelmintic Compounds, Jiarui Li
McKelvey School of Engineering Graduate Student Theses & Dissertations
To address the cuticular barrier in anthelmintic discovery, this study establishes a bifurcated framework in Caenorhabditis elegans. First, HPLC-based quantification of 14 PIM inhibitors revealed that cuticular penetrance is primarily dictated by phylogenetic lineage (Clade V) rather than ecological niche. Specifically, C. elegans demonstrated a significant pharmacokinetic correlation with the hookworm Ancylostoma ceylanicum (Clade V) but not the whipworm Trichuris muris (Clade I), validating it as a superior surrogate model for hookworm bioaccumulation. Within this small molecule inhibitor library, SGI-12was identified as a lead candidate with superior potency against C. elegans and bioaccumulation. Second, target validation using a C. …
Neuropsychological Functioning And Coping Strategy Intervention Approaches In Youth With Posttraumatic Stress Disorder, Kalliopi Megari, Dimitra V. Katsarou, Georgios A. Kougioumtzis, Evangelos Mantsos, Maria Sofologi, Agathi Argyriadi, Alexandros Argyriadis, Efthymia Efthymiou
Neuropsychological Functioning And Coping Strategy Intervention Approaches In Youth With Posttraumatic Stress Disorder, Kalliopi Megari, Dimitra V. Katsarou, Georgios A. Kougioumtzis, Evangelos Mantsos, Maria Sofologi, Agathi Argyriadi, Alexandros Argyriadis, Efthymia Efthymiou
All Works
Background: Posttraumatic stress disorder (PTSD) in ages 3–18 is associated with disturbances in attention, working memory, processing speed, and executive control, as well as persistent difficulties in affect regulation. These neuropsychological vulnerabilities might interfere with learning, peer relationships, and the consolidation of age-appropriate developmental skills. Methods: We conducted a narrative review informed by a structured literature search in PubMed, Scopus, PsycINFO, Embase, EBSCOhost, Web of Science, and Google Scholar. English-language publications from 1990 to 2025 were considered if they examined (1) neuropsychological outcomes of trauma exposure or PTSD in youth and/or (2) interventions with potential to modify neurocognitive or affective …
Population Pharmacokinetics And Dosing Simulations Of Pentobarbital In The Pediatric Population, Victoria Etges Helfer, Lorena Medina-Aymerich, William J. Muller, Marisa Meyer, Amira Al-Uzri, Russell Mcculloh, Chi D. Hornik, Stephen J. Balevic, Rachel G. Greenberg, Daniel K. Benjamin, Sarah G. Anderson, Daniel Gonzalez
Population Pharmacokinetics And Dosing Simulations Of Pentobarbital In The Pediatric Population, Victoria Etges Helfer, Lorena Medina-Aymerich, William J. Muller, Marisa Meyer, Amira Al-Uzri, Russell Mcculloh, Chi D. Hornik, Stephen J. Balevic, Rachel G. Greenberg, Daniel K. Benjamin, Sarah G. Anderson, Daniel Gonzalez
Department of Pediatrics Faculty Papers
Pentobarbital is a barbiturate with sedative and anticonvulsant properties, occasionally used in pediatric patients for preoperative sedation, deep sedation during mechanical ventilation, and seizure control. Despite its long-standing clinical use, age-appropriate dosing remains challenging due to variability across studies and limited pediatric pharmacokinetic (PK) data. This study (NCT01431326) aimed to characterize the population pharmacokinetics of pentobarbital in pediatric patients (birth to 21 years) and evaluate dosing strategies using model-based simulations. A two-compartment population PK model, allometrically scaled to total body weight, adequately described pentobarbital plasma concentrations, with no additional covariates identified as significant. Simulations were conducted across four age groups: …
Cell-Type Specific Control Of Visual Fixation In Drosophila Melanogaster, Meagan Leung
Cell-Type Specific Control Of Visual Fixation In Drosophila Melanogaster, Meagan Leung
Biological Sciences
Navigation in complex environments requires precise visual processing. To move effectively through their surroundings, animals must orient toward and maintain fixation on objects of interest to preserve a stable heading. However, the neural mechanisms underlying this behavior remain poorly understood. We use Drosophila melanogaster as our model organism because its visual behavior can be precisely measured and the availability of genetic tools which enables us to perturb the underlying neural circuits. Using a closed-loop virtual reality environment combined with locomotion tracking, we developed a stimulus protocol that reliably elicits fixation responses. To determine whether specific visual neurons drive fixation responses, …
Albany City As A Case Study In Language Mapping, Storm Pupina
Albany City As A Case Study In Language Mapping, Storm Pupina
Linguistics
This thesis uses Albany, NY, as a case study in urban language mapping, following the example of many other language mapping projects, most notably the NYC Language Mapping Project. Albany's languages and linguistic features were analyzed to better understand the area's linguistic ecology and ongoing heritage-language maintenance efforts. Various types of American Census data were compared to reach the conclusions. Despite not being a major city, Albany is bustling with both new and old language communities. Similar efforts with more varied data-gathering tactics would greatly benefit other American urban landscapes.
Low-Cost Rf Exposure Monitoring With Tinyml Prediction, Sanad Sahawneh
Low-Cost Rf Exposure Monitoring With Tinyml Prediction, Sanad Sahawneh
Nanoscale Science & Engineering (discontinued with class year 2014)
The proliferation of wireless technologies has produced a dense, increasingly heterogeneous radio-frequency (RF) environment that surrounds modern life. While regulatory bodies such as the Federal Communications Commission (FCC) and the World Health Organization (WHO) maintain exposure guidelines, the tools that ordinary people, educators, and small institutions can use to actually observe RF exposure in their own spaces remain expensive, specialized, and largely confined to professional laboratories. Spectrum analyzers and calibrated field probes routinely cost between five hundred and one hundred thousand dollars per unit, placing continuous local monitoring out of reach for most environments where exposure questions are most natural …
An Experimental Study Of The Morphology Of Dna-Carbon Nanotube Hybrid Structures In Direct Dna Sequencing, Avery P. Davis
An Experimental Study Of The Morphology Of Dna-Carbon Nanotube Hybrid Structures In Direct Dna Sequencing, Avery P. Davis
Biomedical Engineering Undergraduate Honors Theses
Hybrid structures formed between single-stranded DNA (ssDNA) and single-walled carbon nanotubes (SWCNT) have emerged as promising components in future direct DNA sequencing technologies due to their unique morphological and electronic properties. The nanoscale configuration of these hybrids, including the DNA wrapping angle, pitch, and contour behavior, directly influences their potential for stable electronic readout. This thesis presents an experimental study of DNA-SWCNT hybrid morphology using a fixed, reproducible wrapping protocol designed to minimize environmental variability and isolate the influence of DNA nucleotide sequence on hybrid structure. As described in prior work, this protocol produces well-dispersed hybrids suitable for high-resolution imaging. …
Long-Term Stimulant Use Is Associated With Normalized White Matter Integrity In The Vta-Nacc Pathway In Adolescents, Isaac T. Arsenault
Long-Term Stimulant Use Is Associated With Normalized White Matter Integrity In The Vta-Nacc Pathway In Adolescents, Isaac T. Arsenault
Biological Sciences Undergraduate Honors Theses
Medical practitioners are diagnosing Attention-Deficit/Hyperactivity Disorder (ADHD) at a high and ever-increasing rate. The use of stimulant medication to treat ADHD is also increasing and is associated with changes in the brain. Past research found that children with ADHD have lower volume in reward neurocircuitry, such as the ventral tegmental area (VTA) and the nucleus accumbens (NAcc). Research has also found that stimulant usage in those with ADHD might “normalize” the reward circuits. However, few longitudinal studies have directly tested the long-term effects of stimulant medication on brain development. Here we tested whether long-term stimulant use is associated with changes …
Examining The Relationship Between Active And Passive Screen Media Design, Engagement, And User Motivation And Impacts On Mental Health In Emerging Adults, Susan Richey
Human Development and Family Sciences Undergraduate Honors Theses
Rates of depression among adolescents and emerging adults have increased in recent years, with screen media use identified as a potential contributing factor. Prior research links passive screen use to poorer mental health outcomes, while active engagement shows mixed effects; however, many studies overlook differences between platform design and actual user behavior, as well as the role of notifications. This study examined how screen media habits, platform design, user motivations, and notification settings relate to mental health among emerging adults. A sample of 399 participants (ages 18–29) from a large southeastern U.S. university completed a survey assessing screen use, engagement …
The Relationship Between Academic Stress And Sleep Quality Among University Students, Braden C. Baker
The Relationship Between Academic Stress And Sleep Quality Among University Students, Braden C. Baker
Finance Undergraduate Honors Theses
This research explores the significance of the question of whether academic stress affects the quality of sleep among university students across the globe. The following research will explore what can cause university students to experience high levels of academic stress, as well as explore ways that universities as a whole can assist with this stress. The research will also dive deeper into what actually causes these students to experience different qualities of sleep and whether high levels of academic stress are actually what causes low quality of sleep.
Throughout this research, a wide variety of studies and data from these …
Romulus As A Rhetorical And Historiographical Tool In Imperial Roman Literature, Jaden M. Perry
Romulus As A Rhetorical And Historiographical Tool In Imperial Roman Literature, Jaden M. Perry
History Undergraduate Honors Theses
This study exames the figure of Romulus in imperial Roman literaure as neither a fixed mythological nor historical subject, but as a flexible rhetorical and historiographical tool. Surveying a range of authors from the late first to fourth centuries CE, inlcuding historians such as Florus, Tacitus, Justin, Suetonius, and the Historia Augusta, as well as literary authors like Juvenal, Silius Italicus, Valerius Maximus, and Seneca, the thesis argues that references to Romulus and his deified counterpart Quirinus are deliberately manipulated to serve distinct authorial purposes. Rather than merely recounting Rome’s foundational myth, these writers employ Romulus to construct comparisons, …
Leveraging Historic Collections: Investigating Morphometric Differentiation In Members Of The Arisaema Triphyllum (L.) Schott (Araceae) Species Complex, Morgan Bradley Russell
Leveraging Historic Collections: Investigating Morphometric Differentiation In Members Of The Arisaema Triphyllum (L.) Schott (Araceae) Species Complex, Morgan Bradley Russell
Graduate Theses and Dissertations
The Jack-in-the-pulpit (Arisaema triphyllum (L.) Schott) is an herbaceous perennial herb of North America, and its taxonomic history is full of confusion and rank shifts. Now split into six species, the A. triphyllum species complex consists of morphologically similar taxa that have differing ploidy levels. In Chapter I, I compiled a detailed introduction and history for these taxa, focusing on their taxonomic complexity and morphological ambiguity in herbarium specimens and immature plants. I also presented their ploidy distinctions and how the implications of polyploidy may hold answers to parsing them apart, especially in dried herbarium specimens where defining characteristics are …
Impact Of Salt Block Utilization During Dry-Aging On Pork Loin Microbial And Meat Quality, Cason H. Frisby
Impact Of Salt Block Utilization During Dry-Aging On Pork Loin Microbial And Meat Quality, Cason H. Frisby
Food Science Undergraduate Honors Theses
This study aimed to investigate the effects of dry-aging and salt block utilization during dry aging on pork loin quality attributes. Pork loins were collected at 7 days postmortem, cut into three equal sections, and randomly assigned to wet aging (WA), traditional dry-aging (DA), and salt block dry-aging (SDA) groups to be aged for 28 days. During the dry-aging period, SDA cabinet exhibited lower humidity fluctuation (Avg. 71.52, St. Dev. 4.7) compared to DA cabinet (Avg 70.76, St. Dev. 7.9). Following the aging period, no differences were found in pH or Warner Bratzler shear force values between treatments (P>0.05). …
Mammalian Biodiversity Of The Easley Conservation Stewardship Area, Grayson C. Belt
Mammalian Biodiversity Of The Easley Conservation Stewardship Area, Grayson C. Belt
Honors College Theses
Monitoring wildlife is an important part of conservation and is particularly vital for newly acquired conservation areas to provide a baseline of what is present. In 2025, the 22 ha Murray State University Easley Conservation Stewardship Area (MSU ECSA) was established following a donation to the university by Melissa Easley. I conducted a survey using trail cameras at the ECSA in fall 2025 and winter 2025/26 to record mammalian diversity. The survey consisted of two subprojects: a mesomammal subproject of 18 knee height trail cams and a small mammal subproject using 15 custom small mammal bucket cameras. I uploaded all …
Exploring The Effects Of Protein Intake On Mood And Sleep Quality In Post-Menopausal Women, Deborah Crouch
Exploring The Effects Of Protein Intake On Mood And Sleep Quality In Post-Menopausal Women, Deborah Crouch
General Human Environmental Sciences Undergraduate Honors Theses
Background: Menopause is a phase of life that roughly half of the world’s population will go through. Although research looking into how the body changes and is impacted by menopause, studies relating to how diet can affect the aging body of post-menopausal women is limited. The objective of this study was to gain insight into how mood and sleep are affected by increasing protein intake in the diet.
Methods: 29 participants were assigned to either a control group (n=20) or a treatment group (n=9). The treatment group was assigned to consume 1.6 g/kg/day of protein, including 7 servings of beef …
Relationship Between Disordered Eating Behaviors And Sport In Female Collegiate Athletes, Elizabeth Files
Relationship Between Disordered Eating Behaviors And Sport In Female Collegiate Athletes, Elizabeth Files
General Human Environmental Sciences Undergraduate Honors Theses
Disordered eating behaviors and body image concerns remain prevalent among collegiate athletes, yet the role of sport type and sport-related environmental factors, such as uniforms, is not fully understood. The purpose of this study was to examine the relationship between sport type, uniform perception, and disordered eating behaviors among female collegiate athletes at the University of Arkansas. A quantitative, non-experimental design was used, with 36 athletes completing an anonymous Qualtrics survey incorporating demographic questions, uniform perception items, and the Eating Disorder Examination Questionnaire Short Form (EDE-QS).
Descriptive analyses indicated a predominantly young (ages 18–21), White, and underclassman sample. Chi-square analyses …
Population Structure And Connectivity Of Atlantic Nurse Sharks (Ginglymostoma Cirratum) In The Bahamas And Outlying Areas, Baylie A. Fadool
Population Structure And Connectivity Of Atlantic Nurse Sharks (Ginglymostoma Cirratum) In The Bahamas And Outlying Areas, Baylie A. Fadool
School of Natural Resources: Dissertations, Theses, and Student Research
Understanding animal ecosystem dynamics and behavior at the individual and population levels is essential for identifying life-history patterns and important areas for management and conservation. Marine fish species often face minimal geographic barriers to movement, but environmental (temperature, salinity, current) or intrinsic barriers (philopatry, site fidelity) can dictate gene flow. Atlantic nurse sharks (Ginglymostoma cirratum) are an International Union for Conservation of Nature (IUCN) listed ‘vulnerable’ species and present a unique opportunity to investigate patterns of population structure and connectivity in large-bodied sharks. They are benthic and display reproductive philopatry, with recent work suggesting they have the capacity …
Exploring Student Sensemaking During A Collaborative Biology Lab, Rebecca Kollipara
Exploring Student Sensemaking During A Collaborative Biology Lab, Rebecca Kollipara
School of Natural Resources: Dissertations, Theses, and Student Research
Collaborative learning environments offer valuable opportunities for students to construct scientific understanding through dialogue, yet the conditions that support sustained conceptual reasoning in group settings remain incompletely understood. While prior research has identified discourse moves associated with productive collaboration, less attention has been paid to how those moves function together across turns and conceptual boundaries, or how individual student characteristics shape their emergence. This thesis examines collaborative sensemaking in an undergraduate General Biology II course, drawing on two complementary analyses of student discourse during a bryophyte life-cycle modeling activity.
Chapter 1 investigates how student groups participated in sensemaking and how …
Gaining Mussel: Evaluating Reintroduction Success Of Native Freshwater Mussels In Nebraska And Eastern Wyoming, Travis A. Moore
Gaining Mussel: Evaluating Reintroduction Success Of Native Freshwater Mussels In Nebraska And Eastern Wyoming, Travis A. Moore
School of Natural Resources: Dissertations, Theses, and Student Research
Freshwater mussels are one of the most imperiled groups of organisms in North America, with over two-thirds of species considered threatened, endangered, or of special concern. These long-lived bivalves are essential to stream ecosystems, acting as filter feeders that improve water quality and as indicators of aquatic health. In Nebraska and Wyoming, native mussel populations have declined sharply due to habitat modification, pollution, and reduced connectivity. Two species of particular concern are the Plain Pocketbook Lampsilis cardium, listed as Tier I at-risk in Nebraska, and the Fatmucket Lampsilis siliquoidea, a Tier II at-risk species. In response, state agencies …
The Impact Of Glucose Exposure On Organic Cation Transporters (Oct) Function In A Corneal Epithelial Cell Line, David A. Garza
The Impact Of Glucose Exposure On Organic Cation Transporters (Oct) Function In A Corneal Epithelial Cell Line, David A. Garza
Theses & Dissertations
Organic cation transporters (OCT) facilitate the movement of neurochemicals and medications, contribute to the removal of cellular waste, and facilitate neuronal communication. Three subtypes of these high-capacity, low-affinity transporters (OCT1, OCT2, and OCT3) are differently expressed in peripheral tissues such as the liver, kidneys, as well as the central nervous system. OCTs are also expressed in ocular tissues. Chronic hyperglycemia is a complication commonly associated with diabetes that can lead to ocular diseases such as diabetic keratopathy, which affects the cornea. In this project, we expose immortalized human corneal epithelial cells (HCE-S) to various glucose concentrations to study their impact …
If It’S A Fit, Perhaps They’Ll Stick: An Examination Of Black Women Teachers, Perceptions Of Fit With Their Schools, And Their Retention In American Public Schools, Taylor M. Young
Graduate Theses, Dissertations, and Capstones
This dissertation examines how perceived person-organization (PO) fit between Black women teachers (BWTs) and characteristics of their respective schools influence their intention to remain at their current school. Using quantitative methods, this study explores how these characteristics predict the likelihood of retention. The study centered (n = 85) BWTs within a full sample of women teachers (N = 125). The findings revealed that perceived PO fit with colleagues, teaching assignment, and student population predicted a higher likelihood of remaining at their current school for both BWTs and the full sample. The study intends to inform recruitment and retention efforts for …
Honeybee Colony Response To Probiotic Supplementation And Grazing Practices, Katya M. Busenitz
Honeybee Colony Response To Probiotic Supplementation And Grazing Practices, Katya M. Busenitz
Department of Entomology: Dissertations, Theses, and Student Research
Honeybee health is a complicated issue. Studies were conducted to scale honeybee (Apis mellifera) health from the microbiome to the landscape. Colony health parameters were measured in response to probiotic administration. Colony capped brood production, colony summer weight gain, and Varroa mite incidence were measured. I found that applications of over-the-counter probiotics did not improve the measured parameters of honeybee health compared to a control group. Results suggest that probiotic application was not beneficial but positive benefits may depend on application method, brand, or strain of probiotics used. I also examined how colony health metrics responded to different …
Beyond The Switch: Identifying Gli2-Associated Secretory Targets For Igm Regulation In Waldenström’S Macroglobulinemia, Trevor Charles Chapman
Beyond The Switch: Identifying Gli2-Associated Secretory Targets For Igm Regulation In Waldenström’S Macroglobulinemia, Trevor Charles Chapman
Master's Theses and Capstones
Waldenström’s Macroglobulinemia (WM) is a rare non-Hodgkin lymphoma characterized by the increased presence of monoclonal IgM circulating in the blood and the infiltration of lymphoplasmacytic cells into the bone marrow. WM cells are heterogeneous, sharing features of both B-lymphocytes and plasma cells while not being able to terminally differentiate. Our labs’ previous work established that inhibiting and knocking down the GLI2 transcription factor effectively reduces IgM secretion in three different WM cell lines. This observed phenotype was discovered to operate through IL-6Rα signaling but whether IgM was regulated transcriptionally was not assessed. GLI2 was initially hypothesized to regulate IgM production …
Conserved Spatial Proximity And Immune-Linked Evolution Of Lncrnas From Protein-Coding Genes In Vertebrates, Sahar Jamialahmadi
Conserved Spatial Proximity And Immune-Linked Evolution Of Lncrnas From Protein-Coding Genes In Vertebrates, Sahar Jamialahmadi
Master's Theses and Capstones
Long non-coding RNAs (lncRNAs) are widespread components of vertebrate genomes, yet theevolutionary principles governing their genomic positioning, origin, and functional associations remain incompletely understood. Here, we performed a comparative genomic analysis across 96 vertebrate species to investigate the spatial relationship between lncRNAs and protein-coding genes, their evolutionary trajectories within gene families, and their functional and genomic contexts.
We show that lncRNAs are consistently positioned in close proximity to protein-codinggenes across vertebrates, with distance distributions significantly deviating from random genomic placement in all species examined. Despite this non-random organization, genome-wide lncRNA–mRNA distance distributions were highly conserved across species. Ancestral state reconstruction …