Digital Commons Network^™

The Effect Of Acute Hypoxia Exposure, With Exercise, On Bone Metabolic Biomarkers, Alyssa Bailly

Health, Exercise, and Sports Sciences ETDs

Hypoxic environments, resulting from decreased atmospheric partial pressure of oxygen, reduce oxygen availability in the blood and tissues, leading to a mismatch between supply and demand. This elicits several physiological adaptations and may influence bone metabolism. Although evidence suggests that hypoxia can modulate bone remodeling through hypoxia-inducible pathways, findings remain mixed, with most data derived from chronic hypoxic exposures in animal and cell culture models. Exercise, an essential stimulus for bone health, may exacerbate hypoxic stress; however, the skeletal response to acute hypoxic exposure combined with exercise remains unclear. We propose that intermittent exercise in hypoxia may increase negative markers …

Microtubules In Breast Cancer: Exploring The Α/Β-Tubulin Toggle Switch And Its Implications In Human Breast Cancer, Annemarie Ianos

Student Theses and Dissertations

Microtubules, composed of a/b-tubulin heterodimers, play a central role in breast cancer tumor growth by polymerizing, leading to metastasis and depolymerizing, contributing to proliferation. Human enzymes protein kinase Ca (PKC-a) and cyclin-dependent kinase 1 (Cdk-1) mediate phosphorylation at sites a:Ser165 and b:Ser172, respectively, influencing the growth of microtubules. It is possible that alternating phosphorylation at these sites contribute to an a/b-tubulin “toggle switch” that mediates microtubule instability and tumor growth.

The project investigates the influence of the toggle switch model on microtubule stability by determining the impact of mutants (a:S165D, a:S165N, a:S165S_P, b:S172S_P and a:S165S_P/b:S172S …

Cfd Simulation Analyses Of The Blowdown Phase Of A Depressurized Loss Of Forced Cooling Accident In A Htgr, Keenan Kresl-Hotz

Nuclear Engineering ETDs

This research numerically investigates the helium-air mixing in HTGR containment cavities during the blowdown phase of a simulated DLOFC accident. The results of the performed CFD simulation analyses, using the commercial code STAR-CCM+, are compared with reported measurements from an experiment conducted at CCNY. The analyses investigate the effects of the RANS and LES turbulence models, numerical mesh refinement, time-step size, and flow rate and temperature of the injected hot helium into the scaled reactor cavity. Calculated parameters analyzed include the pressure and spatial distributions of temperature and oxygen concentration in the simulated reactor and steam generator cavities. CFD oxygen …

Shaping Emergent Competitive And Cooperative Behaviors In Multi-Agent General-Sum Games, Ethan F. Erickson

Honors Projects

Reinforcement learning (RL) algorithms can train agents to solve problems in environments using complex behaviors that are not explicitly programmed, known as emergent behaviors. The goal of our research is to investigate how different RL reward values influence the emergence of competitive and cooperative behaviors in games with teams of multiple agents. Specifically, we focus on general-sum games, in which the sum of gains and losses of each team may be non-zero, allowing situations for agents to mutually benefit or mutually fail. Using Unity’s ML-Agents Toolkit to train agents with RL self-play in bounded 2D environments, we identify high-level behaviors …

Efficacy And Equity In Type 2 Diabetes Care: Comparing Glp-1 Therapy And Dietary Interventions Through Clinical, Social, And Ethical Lenses, Makayla Bogle

Honors Projects

Objective: Explores the clinical and sociocultural dimensions regarding type 2 diabetes (T2DM) care, comparing GLP-1 receptor agonist (GLP-1 RA) therapy and dietary interventions for adults with T2DM. Part I consists of a narrative literature review examining clinical outcomes such as glycemic control, insulin sensitivity, and weight management for the two compared treatment methods. Part II conducts a narrative literature review examining the structural and social determinants that influence access to diabetes treatments. The review evaluates how social determinants of health (SDOH) shape the real-world implementation of both GLP-1 RA therapies and dietary interventions. The discussion highlights differences in measurable clinical …

Ab Initio Method Development For Electronic Structure Response And Symmetry Quantification, Duc Anh Lai

Chemistry Theses and Dissertations

Electronic structure provides a fundamental framework for understanding molecular properties and reactivity, as it encodes the spatial distribution of electrons and their response to external and internal perturbations. This dissertation develops theoretical and computational frameworks to characterize and manipulate electronic structure through two complementary directions: the response to oriented external electric fields and the quantification of symmetry regulation in electron density.

First, a rigorous theoretical and computational framework is established for treating electric fields with arbitrary orientations relative to molecular structure. The concept of the rotational potential energy surface is introduced to characterize the dependence of molecular energy on field …

Undergraduate Commencement Exercises Program, May 16, 2026

Bryant University Commencements

No abstract provided.

Musical Methods For Nonverbal Emotional Expression, Carrie Uddenberg

Music: Student Scholarship & Creative Works

No abstract provided.

The Formation Of Indian Health Services Within Imperial And Settler-Colonial Contexts, Jillian E. Grisel

American Studies ETDs

This dissertation examines the Indian Health Services as a Cold War biosecurity apparatus, showing how infectious disease was weaponized to dismantle treaty obligations, reorganize tribal lands into “service areas,” and reclassify Indigenous nations as surveilled populations. Against this carceral health economy, Indigenous nations refused. From the 1969 Alcatraz occupation to the 1976 Puyallup takeover of Cushman Indian Hospital, Native activists reclaimed health facilities as sovereign spaces, insisting that care is not a discretionary service but a treaty right grounded in land and kinship. Methodologically, I combine historical-legal analysis of congressional debates, Public Health Service reports, and IHS data with counter-archives …

Impact Of Third Trimester Alcohol Exposure (Ttae) On Oligodendrocyte Development And Behavior In Mice, Estrella Villicana

Biomedical Sciences ETDs

Prenatal alcohol exposure (PAE) during late gestation can cause cognitive, behavioral, and motor impairments associated with fetal alcohol spectrum disorders (FASDs). The third trimester corresponds to a critical period of brain growth and maturation. This study examined the effects of Third Trimester-equivalent Alcohol Exposure (TTAE) on oligodendrocyte development and adult behavior. Neonatal mice were exposed to ethanol or air vapor from postnatal day (P) 4–8. Immunohistochemical analyses were performed at P8 and P30 to assess myelination, apoptosis, and oligodendrocyte lineage progression. TTAE significantly reduced myelin basic protein (MBP) expression at P8, which was recovered by P30, indicating delayed developmental myelination. …

Computational Design Of Peptides And Proteins Through Machine Learning Approaches, Emily J. Hendrix

Chemistry and Chemical Biology ETDs

Advancements in machine learning have emerged as a pivotal tool in computational biochemistry, offering new advancements to address challenges in protein structure and function. However, current machine-learning approaches offer limited insight in understanding protein dynamics. The purpose of this work is to combine traditional physics-based computational tools, such as molecular dynamics and coarse-grained simulations, with recently developed AI-driven computational tools to bridge gaps and advance the understanding of proteins in both structural and dynamic aspects. I investigated several approaches such as (i) traditional physics-based methods to study protein conformation and ensembles; (ii) identifying a peptide inhibitor for the PICK1 PDZ …

Nanoscale Structure And Spontaneous Self-Assembly Of Hydrothermal Organic Products, Glorianne P. Dorce

Chemistry and Chemical Biology ETDs

Carbon nanomaterials derived from citric acid and urea exhibit behaviors that challenge conventional structure–property models based on static bulk descriptions. This study examines how precursor pairing and reaction duration, post‑synthetic thermal history, and time‑dependent aging govern nanoscale organization and optical response. Through controlled synthesis and processing, distinct nanostructures with tunable structural and spectroscopic profiles are generated.

A multiscale framework integrating nano‑FTIR, atomic force microscopy, and thermal analysis reveals chemical heterogeneity and continuous structural reorganization across length scales. By correlating local chemical environments with optical behavior, we show that fluorescence efficiency and photostability depend on specific nanoscale architectures rather than average …

Spring Graduate School Commencement: May 16, 2026, University Of North Dakota

UND Commencement Programs

UND Spring Graduate School Commencement program from May 16, 2026.

Mapping Homogeneous Configuration States For Learning Based Motion Planners, Yazied Hasan

Computer Science ETDs

Reinforcement learning (RL) excels at solving complex tasks, but training times can become prohibitively large for challenging motion-planning problems. Methods that address this cost often require additional training or tuning, counteracting the goal of reducing training time. A more effective approach is to exploit inherent task equivalences: many elements of the state space, dynamics, or structure are functionally interchangeable, enabling simplification or knowledge reuse. We present learning solutions that leverage these equivalences to enhance the RL process. First, we leverage the symmetry of homogeneous multi-agent teams to simplify the task to a single strategy. Second, we map correspondences between distinct …

Identification Of Aortic Centerline Shape Features, Bebel B. Trani

Mechanical Engineering and Materials Science Independent Study

Better predictions of the likelihood of an aortic event in patients are paramount to providing quality care in medicine. Ascending aortic aneurysms (AsAA) are typically asymptomatic until sudden complications, such as rupture or dissection, occur and are often fatal [1]. As a form of preventative care, physicians identify and monitor high-risk patients. Surgical interventions are also performed for high-risk patients, replacing the weakened segment of the ascending aorta before a catastrophic event occurs. Determining which patients require surgical intervention or close monitoring is therefore extremely important. These decisions are largely guided by maximum diameter measurements; for the ascending aorta, a …

2026 Lynn University Commencement Program, Lynn University

Commencement Programs

The commencement exercises program for Lynn University's class of 2025. The ceremony, held on Saturday, May 16, 2026 at the Palm Beach Convention Center, included all graduating students (undergraduates and graduates).

The commencement speaker was was Bruce J. Himelstein, former Chief Sales & Marketing Officer of the Ritz-Carlton Hotel Company and Loews Hotels.

Cyanogenesis Variation In White Clover Is Decoupled From Regional Climate And Human Footprint Across A Longitudinal Gradient, Philips O. Akinwole, Yangjie Tan, Victor L. Alfonso

Biology Faculty publications

Latitudinal clines in adaptive traits are well documented, yet how such patterns translate across longitudinal gradients, where climatic variation is reduced, remains poorly understood. We investigated spatial variation in hydrogen cyanide (HCN) - a well-characterized anti-herbivore defense polymorphism governed by two independently segregating loci (Ac and Li), in white clover (Trifolium repens) across nine Midwestern U.S. cities. A total of 269 populations (4,035 individuals) were sampled along urban-rural transects, and cyanotype (cyanogenesis phenotypes) frequencies were quantified alongside regional and site-level environmental variables, including vegetation cover (NDVI), land surface temperature (LST), snow cover, impervious surface intensity, aridity, …

Assessing Uranyl-Specific Dnazymes And Dna-Aptamers For Uranium Binding In Environmentally Relevant Waters, Ashley R. Apodaca-Sparks

Civil Engineering ETDs

The legacy of uranium mining affects many communities in the western United States, resulting in elevated levels of uranium in surface water. The ability to quickly and accurately detect uranium on site in affected communities can lead to real-time water quality analysis that informs risk assessment and remediation efforts. The objective of this work is to advance the application of biosensing technologies for the measurement of uranium in waters affected by mining legacy. The third chapter of this thesis compares ANDalyze by AlpHa Instruments, a commercially available uranium biosensor, and inductively coupled plasma mass spectrometry (an EPA-verified method for uranium …

Active Memory Civil Association Vs. Argentina, Kamila Knaudt

Loyola of Los Angeles International and Comparative Law Review

This case is about the botched investigation of the bombing of the building hosting the Asociación Mutual Israelita Argentina, (AMIA) in Buenos Aires, Argentina. The State admitted responsibility for the faulty investigation, which took more than twenty years, and the Court found Argentina in violation of several articles of the American Convention.

Córdoba V. Paraguay, Madeline Prokop

Loyola of Los Angeles International and Comparative Law Review

This case is about the abduction in Argentina of a minor by a parent. The child was taken to Paraguay without the father’s consent. It took more than nine years for Paraguay to return the child to Argentina. The Court found Paraguay in violation of several articles of the American Convention for the prolonged return proceedings.

Heavy Metal And Metalloid Accumulation In The Gallinas River Following The Hermit's Peak / Calf Canyon Wildfire, Olivia A. Kelly

Geography ETDs

This study evaluates the persistence and bioavailability of heavy metals and metalloids in the Gallinas River three years after the Hermit’s Peak/Calf Canyon Wildfire of 2022 using a multicompartment sampling framework that includes water, sediment, and benthic macroinvertebrate tissue analysis via inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Results indicate that the Hermit’s Peak/Calf Canyon Fire continues to influence the hydrogeochemical condition of the Gallinas River. Sediments contain elevated concentrations of several metals and metalloids, and these same elements are detectable in macroinvertebrate tissues, linking sediment contamination to biological uptake. Zinc (Zn), silicon …

Hybrid Densenet-U-Net Framework For Automated Grading Of Renal Cell Carcinoma, Rohini Jadhav, Banani Mohapatra, Bhavnish Walia, Sital Dash, Kailas Patil, Shrikant Jadhav, Ishwari Rohit Raskar

Faculty Research, Scholarly, and Creative Activity

Introduction: Precisely grading renal cell carcinoma (RCC) through histopathology slides is a requisite to predict the cancer prognosis and select treatments, however, there is a considerable variability in the assessment between observers. While some AI systems mainly rely on transformer-based and nuclei-centric models, they are computationally very demanding so their clinical use is thus limited. Hence, there is a need for practical and easy-to-understand solutions that can be integrated into digital pathology workflows. Methods: We built a hybrid framework that integrates U-Net-based tumor segmentation, convolutional feature extraction, nuclei-aware descriptors, stain normalization, and attention-based multiple instance learning for slide-level RCC grading. …

Developing A Durable, Memory-Driven, Cspz-Targeting Lyme Disease Vaccine By Rationale Adjuvant Selection\, Miranda Mccarty, Sergio A Hernández, Jill Malfetano, Ana Carolina Leão, Maria Jose Villar, Xiuli Yang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Ulrich Strych, Maria Elena Bottazzi, Utpal Pal, Klemen Strle, Wen-Hsiang Chen, Yi-Pin Lin

Faculty, Staff and Students Publications

Rational adjuvant selection is a systematic approach based on adjuvant-mediated immunomodulation to identify safe vaccine regimens that enhance protective immunity. Transmitted through ticks and caused by the bacterium Borrelia burgdorferi (Bb), Lyme disease (LD) is the most common vector-borne disease in the Northern hemisphere. There are no approved human vaccines, making it suitable for testing the concept of rational adjuvant selection. Here, we formulated our previously developed and effective LD vaccine antigen, CspZ-YAC187S, with different adjuvants suitable for human use; we analyzed the immune response by transcriptomics and tested the vaccine efficacy after Bb infection. We identified Alum-CpG and Alum-αGal …

Development And Preliminary Effectiveness Of Sel-Based Puzzle Media For Improving Emotional Regulation In Second-Grade Elementary Students, Kun Widya Nurfiani, Diana Septi Purnama

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study developed and evaluated the feasibility, practicality, and preliminary effectiveness of the Social Emotional Learning (SEL)-based Puzzle Expression Emotion media to improve emotional regulation among second-grade elementary school students. The study used a Research and Development design following the ADDIE model. Feasibility was assessed by subject-matter and media experts, practicality by classroom teachers, and preliminary effectiveness through a one-group pretest-posttest field trial involving 51 students from two public elementary schools in Surakarta. Data were collected through interviews, observations, validation sheets, practicality questionnaires, and an emotional regulation instrument. Quantitative data were analyzed descriptively, followed by a paired-sample t-test and N-gain …

Behind The Scores: How Federal Education Legislation Influenced Dayton Public Schools’ Special Education System For Students Of Color, Simran Kaur

Aurora

This paper analyzes the district special education system of Dayton Public Schools’ through federal legislation requirements and state-reported data to evaluate access, implementation, and equity. Findings show that while the district meets several procedural requirements at federal levels, students with disabilities (especially Black students) face limited access to general education environments, family engagement, and disability identification at a local level. Risk ratios reveal subjective disability categories, which is contributing to the district’s low Achievement Gap Closing rate through the state-wide report card.

Birth Control Use Alters Memory For A Stressful Experience, Julia N. Gross, Kristie Payment, Boyd R. Rorabaugh, Phillip R. Zoladz

Aurora

Hormonal birth control methods are widely used; however, some users suffer considerable side effects. Previous research suggests oral contraceptive users exhibit a blunted cortisol response to psychosocial stressors and alterations in emotional memory, including differential recall of emotional images and details of emotional stories. However, no studies have examined how birth control influences memory for a stressful experience.

The present study analyzes data previously collected from female undergraduate students. In this study, participants reported contraceptive use, then underwent a modified version of the Trier Social Stress Test (TSST) or the friendly-TSST (f-TSST). The TSST required participants to deliver a ten-minute, …

Understanding Counselor Burnout From An Ecological Systems Perspective, Stephanie Thorson-Olesen, Lisa Belknap, Emily Velidow, Jessica Gaul, Phoenix Rosewood, Nayara Aparecida Da Costa Silva Beall

Journal of Counselor Preparation and Supervision

Using Bronfenbrenner’s Ecological Systems Theory as a guiding framework, this study explored the experiences of licensed counselors who self-identified as having recovered from burnout. Burnout was conceptualized as a prolonged response to chronic occupational stress, while participants were invited to describe their experiences based on their own lived understandings of the phenomenon. A qualitative thematic analysis was conducted using data collected through an anonymous online survey featuring open-ended prompts. Participants included 32 licensed counselors who graduated from CACREP-accredited programs and reported previously experiencing burnout and no longer identifying as currently burned out. Thematic analysis yielded nine interrelated themes encompassing contributors, …

Navigating The Intersection Of Artificial Intelligence And Counseling: Implications For Counselor Identity, Ethics, And Counselor Education, Anabel Mifsud, Barbara Herlihy

Journal of Counselor Preparation and Supervision

This article examines the ethical, professional identity, and counselor education implications of integrating artificial intelligence (AI) into counseling practice. As AI use expands in mental health care, it offers opportunities to enhance accessibility and efficiency while raising complex ethical concerns regarding competence, accountability, transparency, confidentiality, equity, and preservation of the therapeutic relationship. The authors explore how AI may reshape counselor roles and professional identity, underscoring the need to safeguard core values and the relational foundation of counseling. Recommendations are offered for adapting counselor education to prepare future practitioners for AI-augmented practice. The authors call for sustained, critical dialogue to ensure …

Everything I Do Not Understand, James Croal Jackson

Studio One

No abstract provided.

Studio One Volume 50, Studio1 Literary Club

Studio One

No abstract provided.