Digital Commons Network^™

The Phosphatidylinositol 3-Kinase As A Potential Diagnostic Marker For Beta-Thalassemia And Its Correlation With Hemoglobin Profiles, Duaa K. Mohammed, Layla O. Farhan

Baghdad Science Journal

The erythropoietic dysfunction and iron insufficiency associated with β -Thalassemia (β -TH) underscore the importance of augmenting traditional diagnostic techniques with independent biomarkers, beyond standard panels. This single-center case–control study (n = 120 β -TH major, 55; β -TH intermedia, 25; control, 40) examined whether circulating phosphatidylinositol-3-kinase (PI3K) distinguishes patients from controls and correlates with hemoglobin fractions. The serum PI3K was significantly higher in β -TH (p < 0.001), with excellent discrimination tested in serum (AUC = 0.934; optimal cut-off > 1301 pg/mL; sensitivity 100%, specificity 80%). In a multivariable model, HbA₂% and HbF% were both positively and independently associated with PI3K. These results are biologically consistent with the interaction of erythroid …

T2b Gallbladder Adenocarcinoma Diagnosed By Frozen Section With High-Grade Dysplasia At The Cystic Duct Margin: Diagnostic And Prognostic Considerations, Christopher M. Ahmad, Rachana Tadakamalla, Rae-Anne Kastle, Salman Muqeet, Amer Abboud

Student Publications

Gallbladder adenocarcinoma is an uncommon gastrointestinal malignancy that is frequently discovered incidentally during cholecystectomy. Intraoperative frozen section is often used to guide surgical decision-making but has inherent limitations, particularly in assessing depth of invasion. We report the case of a 78-year-old female who underwent an elective laparoscopic cholecystectomy for a gallbladder mass. Intraoperative frozen section demonstrated a tubulovillous adenoma with at least carcinoma in situ. Subsequent permanent histologic evaluation revealed a moderately differentiated adenocarcinoma invading the hepatic-side perimuscular connective tissue, consistent with pT2b disease. Despite the advanced T stage, the tumor exhibited several relatively favorable histologic features, including negative margins …

Comprehensive Mass Spectrometry Screening-Derived Atlas Of Hdac Inhibitors Reveals Histone-Specific Acetylation Changes, Rashmi Karki, Francisca N De Luna Vitorino, Richard M Searfoss, Joanna K Lempiäinen, Cheryl H Arrowsmith, Benjamin A Garcia

2020-Current year OA Pubs

Histone deacetylase inhibitors (HDACis) have emerged as valuable therapeutics for cancer and other diseases; however, their effects on histone post-translational modification remain poorly characterized. Here, we applied quantitative mass spectrometry and high-throughput sequencing to systematically profile site-specific changes in histone modifications in response to a panel of HDACis. This platform enabled mapping of histone modification changes across hundreds of sites, including low-abundance histone marks. Furthermore, an integrative analysis of chromatin immunoprecipitation followed by sequencing (ChIP-seq) and RNA-sequencing (RNA-seq) data identified genome-wide binding sites for the low-abundance histone modification of H2A.Z acetylation in HeLa and MDA-MB-231 breast cancer cells, highlighting the …

The Metric Field And Its Primitives, Steven Kirkland

Defensive Publications Series

The Metric Field and Its Primitives is the formal-mathematics layer of a research project whose popular-science companion, Inners Guide to the Hyper Loop, ships the story. This volume ships the mathematics: definitions, theorems, proofs, falsifier ladders, and the algebra the framework reads across substrates from atomic spectra to slime moulds to the cosmic substrate.

The framework. A candidate fundamental framing under Metric Field Ontology (MFO) commitments. The conventional readings of physics — general relativity, quantum field theory, the Standard Model, ΛCDM cosmology, M-theory's eleven-dimensional supergravity — are preserved at the mathematical level. What is shifted is the ontological framing: …

Ocular Neuro‑Restoration System (Onrs): A Non‑Invasive Ultrasound‑Driven Drug Delivery & Biomarker Platform, Michael Victor Caldwell Mr.

Defensive Publications Series

The Ocular Neuro‑Restoration System (ONRS) is a non‑invasive, wearable ultrasound platform designed to deliver neuroprotective and vascular‑restorative therapeutics to the retina, optic nerve head, and posterior eye without injections. The system uses low‑intensity focused ultrasound (LIFU), vortex‑phase acoustic fields, microbubble‑enhanced sonoporation, and microfluidic tear‑exchange diagnostics to overcome the anatomical barriers that normally block ocular drug delivery.

A CMUT phased array generates controlled acoustic streaming and reversible tight‑junction modulation, enabling 10–50× enhanced penetration of small molecules and biologics, consistent with published evidence that ultrasound increases ocular permeability and drug transport .

A PDMS microfluidic gel‑refresh system maintains uniform coupling and eliminates …

Advances In Kenaf Fibre Reinforced Biocomposites: Processing Techniques, Performance Optimisation, And Future Research Directions, Thomas Adedayo Ayorinde, Tamba Jamiru, Peet F Le Roux, Basiru Philip Aramide, Oluwafemi Emmanuel Ogundahunsi

Engineering and Technology Journal

Kenaf fibre-reinforced composites have attracted considerable interest lately as eco-friendly materials due to their light weight, renewability, degradability, and favourable specific mechanical properties. Despite the advances already achieved in natural fibre composites, the commercial-scale use of kenaf-based composites has been hindered by variations in raw material quality, moisture sensitivity, interphase degradation, thermal instability, and other processing issues. This review critically assesses the morphology, reinforcement behaviour, fibre extraction methods, surface treatments, manufacturing processes, and characterisation techniques employed for kenaf fibre-reinforced composites within the framework of performance and sustainability. The study shows that no extraction and manufacturing process simultaneously optimises fibre integrity, …

Ambient Pre-Conscious Intelligence (Api), Johny Manuel-Devadoss, Deepthi Prasad, Jayden Jack Johnson

Defensive Publications Series

Current artificial intelligence systems are, in practice, still largely reactive in nature. Even the most advanced assistants typically require explicit user prompts, clearly observable interaction events, or high-confidence inference of user intent before they engage in meaningful computational support. As a result, there is an inherent delay between the moment a cognitive need begins to emerge and the moment a system is able to respond. This delay is not merely a technical limitation; it introduces measurable friction into everyday human–computer interaction. In complex, information-dense environments, this friction accumulates, contributing to increased task-switching costs, reduced continuity of thought, and elevated cognitive …

Crime-Related Media Consumption And Fear Of Crime Victimization: The Moderating Roles Of Stress And Coping, Katelyn Elizabeth Byers

Walden Dissertations and Doctoral Studies

No abstract provided.

Popgenhelpr: An R Package To Streamline And Facilitate Informed Population Genomic Analyses And Visualization Of Genetic Ancestry, Diversity And Differentiation, Keaka Farleigh, Mason O. Murphy, Christopher Marie Blair, Tereza Jezkova

Publications and Research

Analysing large population genomic datasets requires an interdisciplinary skillset. Beyond a knowledge base in genetics and population biology, population genomic analyses involve computer science and statistics, representing a barrier for researchers without experience in those fields. PopGenHelpR seeks to lower this barrier by enabling researchers to perform population genomic analyses and generate near-publication quality figures in a streamlined and informed fashion. PopGenHelpR allows users to estimate genetic diversity within populations as well as differentiation among populations and individuals from single nucleotide polymorphism data. PopGenHelpR includes commonly used measures such as observed heterozygosity and FST. PopGenHelpR also provides five …

A Review Of Full-Lifecycle Management Practices For Blue Mining Centered On Sustainable Development And Resource Efficiency, Hou Zhengmeng, Zhang Shengyou, Chen Qianjun, Sun Wei, Zhang Tian, Cai Nan, Huang Liangchao, Wang Qichen, Shi Tianle, Xu Xiaochuan

Coal Geology & Exploration

Against the backdrop of China’s goals of peak carbon dioxide emissions and carbon neutrality, along with the growing demand for critical minerals, this study presents a systematic review of domestic and international literature and engineering cases. Based on the Blue Mining concept proposed by Langefeld’s team of the Clausthal University of Technology and from the perspective of planning forward, this study organizes key technologies, treatment pathways, and essentials of full-lifecycle management used to transition mines from single-purpose stopes to multifunctional infrastructures. Centered on four guiding principles, i.e., energy, ergonomics, water resources, and circularity, this study reviews the synergetic planning process …

Confronting Inequality: Three Eras Of Gender And Tax Scholarship, Bridget J. Crawford

Loyola of Los Angeles Law Review

Tax law is not neutral—it encodes social values and reinforces certain longstanding hierarchies. For over fifty years, legal scholarship at the intersection of gender and tax has exposed how seemingly neutral tax laws perpetuate gender inequality. This Article uses the metaphor of quilting to trace the evolution of this scholarly field across three distinct eras.

Part I names and defines the designing era (1971–1986), which began with Grace Blumberg’s writing on the gendered impact of tax laws on marriage, labor, and caregiving; she framed taxation as a tool of social control over women. Blumberg’s work laid the foundation for other …

Epileptic Seizure Prediction From Eeg Using Continual Learning With Cnns, Adnan Amin, Ammar Bathich, Feras Al-Obeidat, Safa Naes, Maria Jose Sousa

All Works

Epilepsy is a persistent neurological disorder that affects over 50 million people worldwide, with nearly one-third of patients remaining unresponsive to conventional therapeutic treatments. This study introduces a progressively adaptive seizure prediction framework designed to enhance early detection and clinical decision-making. The proposed model employs a deep learning strategy grounded in continual learning (CL) principles, using Convolutional Neural Networks (CNNs) in combination with knowledge distillation techniques. This enables the model to assimilate new data while retaining previously learned information. The approach was evaluated on the publicly available Bonn University EEG dataset, following a sequential learning process in which each successive …

Symmetry And Psychosocial Adaptation To Trauma, Illness And Disability Part I: Views From Physics, Medicine And Psychology, Hanoch Livneh

Leadership, Learning and Counseling Faculty Publications and Presentations

The aim of this two-part paper is to discuss the concept of symmetry and its derivatives, symmetry breaking and asymmetry, and the role they assume in elucidating the structure and processes that underlie psychosocial adaptation to traumatic experiences. To achieve this aim, in Part I, first, a cursory review of symmetry is undertaken as it applies to physics, including conservation laws, the forces of nature, and leading theories of nature. Second, the paper addresses how symmetry is perceived in biology and medicine, including symmetry within biochemical and genetic structures, the human body, and the onset of disease processes. Third, the …

Biogeochemical Mechanisms Behind Water Quality Evolution And Valuable Element Reutilization Of Abandoned Mine Drainage: A Review, Wu Pan, Huang Jiangxun, Li Qingguang, Zhang Ruixue, Li Bo

Coal Geology & Exploration

Background Abandoned mine drainage, also known as acidic mine drainage (AMD), represents a major pollution source in mining areas while also serving as an important carrier of strategic critical metals and underground space utilization. In China, water pollution stemming from coal mining is more severe in the south than in the north. This spatial pattern is jointly shaped by climatic conditions, geological settings, and mining history. Advances From the perspective of the environmental geochemical frontier, this study presents a systematic review of AMD formation and evolution mechanisms, as well as technologies for water pollution prevention and control, resource recovery, and …

A Disorder-Aware Computational Framework To Identify Structurally Tractable Targets In Proliferative Vitreoretinopathy, Mak B. Djulbegovic, Nedym Hadzijahic, David J. Taylor Gonzalez, Michael Antonietti, Sidra Zafar, Ajay E. Kuriyan

Wills Eye Hospital Papers

OBJECTIVE: Proliferative vitreoretinopathy (PVR) remains a major cause of failure after rhegmatogenous retinal detachment repair and lacks effective pharmacologic therapies. Although epithelial-mesenchymal transition (EMT) is central to PVR pathogenesis, the structural determinants governing the tractability of EMT regulators, particularly those involving intrinsic disorder, remain poorly defined. We developed a disorder-aware, artificial intelligence-enabled computational framework to evaluate EMT-associated proteins in PVR and prioritize structurally tractable regulators for structure-based targeting.

DESIGN: A computational, hypothesis-generating study employing an in silico screening and structural modeling pipeline.

SUBJECTS: No human subjects or biological specimens were included. The dataset comprised 25 EMT-associated proteins implicated in PVR, …

Probiotic Intake Related To Hemoglobin A1c Among U.S. Veterans With Type 2 Diabetes Mellitus, Maryann Martin

Walden Dissertations and Doctoral Studies

No abstract provided.

Examining School Principals’ Perceptions Of The Challenges That Impede Instructional Leadership, Dan Hartman

Walden Dissertations and Doctoral Studies

No abstract provided.

Exploring Child Welfare Social Workers’ Professional Versus Personal Values Regarding Medication-Assisted Treatment, Natalie Renee Avery Green

Walden Dissertations and Doctoral Studies

No abstract provided.

A Neutrosophic Interpretation Of The Island Rule: From The Tethys Ocean To Urban Gigantism In Freshwater Crabs, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Bibliometric Study Of Neutrosophy As An Emerging Discipline, Miguel Cruz Ramírez, Osvaldo Jesús Rojas Velázquez, Elio H. Cables

Neutrosophic Sets and Systems

No abstract provided.

Injectable, In Situ Forming Peptide Nanofiber Reinforced Composite Hydrogels For Age-Related Macular Degeneration, Shambhavi Bagewadi Ms

Theses and Dissertations

Cell therapy for age-related macular degeneration (AMD) is limited by the absence of a functional substrate such as Bruch’s membrane (BM), which is critical for retinal pigment epithelial (RPE) cell survival and integration. Although preformed substrates have been explored, their implantation can disrupt the fragile retinal architecture, compromise ocular immune privilege and increase infection risk. To address these limitations, an injectable hydrogel capable of forming in situ was developed. The hydrogel consists of thiol-modified hyaluronic acid (HA-SH) and polyvinyl alcohol (PVA). Peptide nanofibers were incorporated to enhance structural reinforcement. Three self-assembling peptides - RADA-16, GAGA and GAGA-YIGSR were designed and …

Trends In The Management Of Acute Pyogenic Flexor Tenosynovitis Of The Hand: A Comprehensive Analysis., Michael Anderson, Taylor J Manes, Davis Hedbany, Sylvester Okoro, Nithin Gupta, Morgan Turnow, Stephen Berling

Ambulatory and Primary Care Articles

Background Acute pyogenic flexor tenosynovitis (APFT) is typically managed operatively, but there is growing interest in nonoperative treatments using intravenous (IV) antibiotics to reduce surgical complications. Timely intervention is essential, as delayed treatment increases the risk of systemic, life-threatening infections. This study aimed to characterize national trends in the operative management of APFT and to compare mortality and amputation outcomes between operatively and nonoperatively managed patients. Methods A retrospective analysis was conducted using data from the TriNetX United States Collaborative Network from 2015 to 2023. Patients were identified using ICD-10 and CPT codes and categorized into operative and nonoperative cohorts, …

Continuity Of Care For Alcohol Use Disorder Patients Using Telehealth During The Covid-19 Pandemic, Martine Beaubrun

Walden Dissertations and Doctoral Studies

No abstract provided.

Perceived Concepts Which Influence Initial Methamphetamine Use Amongst Young Latina Women, Rebeca Rivera

Walden Dissertations and Doctoral Studies

No abstract provided.

Family Caregivers’ Experiences Of Caring For Virally Nonsuppressed Hiv-Positive Adolescents In Uganda, James Byarugaba

Walden Dissertations and Doctoral Studies

No abstract provided.

Phytochemical Composition And Bioactivities Of Roselle (Hibiscus Sabdariffa L.) Extracts Obtained By Infusion, Ethanolic Maceration, And Maltodextrin-Assisted Drying, Risna Silvianti, Warsito Warsito, Elok Zubaidah, Zubaidah Ningsih, Aqidatul Izza

Karbala International Journal of Modern Science

Roselle (Hibiscus sabdariffa L.) is rich in phenolic compounds and anthocyanins, but the extraction method may influence its chemical composition and biological activity. This study compared hot-water infusion, ethanolic maceration, and maltodextrin-assisted drying. It aimed to examine the relationship between the extraction method, chemical profile, and bioactivity. The resulting extracts (EI, EM, and EP) were analyzed for total phenolic, flavonoid, and anthocyanin, LC-HRMS profiles, and antioxidant capacity by the FRAP assay. Antibacterial analysis was conducted against Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923) using agar well diffusion. Cytotoxicity tests (MTT, 24 h) were performed against HT-29, 4T1, …

The Utilization Of Interactive Learning Videos To Improve Critical Thinking In Social Studies Learning Among Grade V Students At Sd Negeri 1 Kota Fajar, Cut Oktanalisa, Lili Kasmini

Jurnal Pendidikan Humaniora

Critical thinking is an essential competency for elementary students because it enables them to interpret information, analyze everyday problems, evaluate reasons, and communicate responsible decisions. In social studies learning, this competency needs to be developed through contextual, dialogic, and visually supported learning experiences. This study investigated the utilization of interactive learning videos to improve the critical thinking skills of Grade V students at SD Negeri 1 Kotafajar. The study employed a qualitative descriptive design supported by quantitative descriptive data. The participants were 30 Grade V students in the 2024/2025 academic year. Data were collected through pretest and posttest tasks, classroom …

Caring For The Carers: Exploring The Mental Wellbeing Of Informal Palliative Caregivers Of Cancer Patients In Kenya, James Kariuki, Rose Njiraini

Journal of Global Awareness

Cancer cases have been on the increase globally, and this has led to economic burden on the affected households. One way of reducing the cost of care is through home-based care by informal palliative caregivers who include family members, friends, and other people assigned by the family members to take care of the patient. The objectives of this study were to assess the status of the mental wellbeing of palliative caregivers of cancer patients; to examine the relationship between the ability of the patient to cope with cancer diagnosis and the mental wellbeing of the caregiver; and to investigate the …

Heroism As Emotional Integration: A Process Model Of Emotion-Driven Heroic Action, Scott T. Allison

Heroism Science

Heroism is often framed as the expression of prosocial motivation fueled by positive emotions such as empathy, compassion, and moral elevation. This perspective, however, overlooks the complex emotional dynamics that characterize high‑risk, morally consequential action. This article advances a process model of heroism as emotional integration, involving the dynamic coordination of multiple and often competing emotions—including fear, anger, compassion, and moral concern—under conditions of uncertainty and threat. Drawing on research in heroism studies, positive psychology, and affective science, the model distinguishes heroism from ordinary helping by emphasizing emotional conflict, regulatory processes, and identity‑based commitment. It further differentiates rapid, intuitive …

The Machine For Its Own Sake: Tolkien's Critique Of Instrumental Reason And The Modern Ecological Ethos, Ahmad J. El-Youssef

Journal of Tolkien Research

This essay examines J.R.R. Tolkien's legendarium as a systematic critique of instrumental reason, positioning his work as a vital philosophical resource for diagnosing and navigating the Anthropocene. Rather than a simplistic anti-technology stance, Tolkien's concept of the "Machine" represents a teleological logic that reduces the living world to a standing reserve, paralleling contemporary ecological crises. Through analysis of key narratives, particularly the industrialisation of Isengard, the corruption of the Shire, and the restoration of Lothlórien, this study demonstrates how Tolkien dramatises the ontological flattening inherent in instrumentalist domination. The essay contrasts this with Tolkien's alternative ethos of sub-creation and stewardship, …