Digital Commons Network^™

Towards Efficient Continual Learning: From Memory Optimization To Foundation Models, Zilin Luo

Dissertations and Theses Collection (Open Access)

Continual learning, also termed lifelong learning, enables machine learning models to incrementally acquire new knowledge while mitigating the degradation of previously learned information—a capability essential for adapting to dynamic, real-world data environments. This dissertation investigates the core challenges of continual learning and extends its application to enhancing training efficiency in the era of foundation models. The first part of this dissertation addresses the constraints of few-shot exemplar storage with a novel compression framework. While leveraging class activation maps to downsample non-discriminative pixels, we introduce an adaptive masking model, optimized through bilevel optimization, to store more exemplars efficiently. The second part …

The Phoenix Flora: Plant Survival, Succession, And Putative Adaptation In The Post-Atomic Landscapes Of Hiroshima And Nagasaki, Gian Marco Ludo, Paola Amelia Tassi, Alba Iannotti, Colomba Russo, Fausto D'Agostino, Matilde Neble Segade, Timothy Mousseau, Andrea Malizia

Faculty Publications

The atomic bombings of Hiroshima and Nagasaki in 1945 created a unique environment of acute, high-dose ionizing radiation, contrasting sharply with the chronic low-dose rate exposure in the Chernobyl and Fukushima Exclusion Zones. This stands in stark contrast to the chronic, low-dose rate contamination that defines the Chernobyl and Fukushima Exclusion Zones. While the long-term ecological effects of the latter are well-documented, a systematic synthesis of the floral response to the atomic bombings is lacking. This review integrates historical data with modern radio-ecological principles to analyze plant survival and succession. We document the remarkable recovery of vegetation, from the resprouting …

Design And Characterization Of A Pulsed Electric Field Chamber For Microalgae Lysis, Connor Strutin

Electrical Engineering

Microalgae are a promising renewable source of biofuel due to their high lipid content and rapid growth rates; however, algae cells must be electroporated (lysed) to release these lipids. The system developed in this project applies short (40 μs–10 ms), high-intensity (up to 33 kV/cm) pulsed electric fields (PEF) across cell membranes to enable electroporation.

Our lab-scale PEF chamber generates uniform, high-intensity electric fields using parallel-plate electrodes with sub-millimeter spacing. The system is designed to efficiently lyse microalgae cells for lipid extraction and biofuel production.

Contributor Bios, Editorial Board

Intertidal

No abstract provided.

Rooted, Amelia Flint

Intertidal

No abstract provided.

Oral Health And Alzheimer’S Disease: The Systemic Connection, Anne O. Rice Bs, Rdh

Metro Denver Dental Society Articulator Magazine

This evidence-based article examines the research connecting oral inflammation and periodontal disease with Alzheimer’s disease and cognitive decline. The author, Anne O. Rice, explores inflammatory, vascular, microbial and airway-related pathways that may contribute to neurodegeneration. Practical applications for dental professionals are highlighted, including blood pressure screening, periodontal therapy, airway assessment and interdisciplinary collaboration. The article positions dentistry as an important contributor to preventive, whole-person healthcare and dementia risk reduction.

Biomedgraphica: An All-In-One Platform For Joint Textual Biomedical Prior Knowledge And Numeric Graph Generation, Heming Zhang, Shunning Liang, Tim Xu, Wenyu Li, Di Huang, Yuhan Dong, Philip Miller, Peter Goedegebuure, Marco Sardiello, Jonathan Cooper, William Buchser, Patricia Dickson, Ryan C Fields, Carlos Cruchaga, Yixin Chen, Michael Province, Philip Payne, Fuhai Li, Et Al.

2020-Current year OA Pubs

MOTIVATION: Multiomics data analysis is essential for scientific discovery in precision medicine. However, translating analysis results of omics data analysis into novel scientific hypotheses remains a significant challenge. Human experts must manually review analysis results and generate new hypotheses based on extensive and interconnected biomedical prior knowledge, which is subjective and not scalable. While large language models can accelerate the discovery, their reasoning improves when grounded in structured, auditable, and comprehensive biomedical prior knowledge. However, biomedical knowledge is scattered across heterogeneous databases that use diverse and inconsistent nomenclature systems, making it difficult to integrate resources into a unified format for …

Effects Of Led Light Spectra And 1-Mcp On Postharvest Quality And Bioactive Compounds Of Cucumber (Cucumis Sativus L.) During Cold Storage, Imad Eldin Abbas Yousif

Theses

Extending postharvest quality and maintaining the nutritional value of cucumber fruit requires specific storage conditions to postpone senescence and enhance marketability. The postharvest lighting environment is a main factor that influences quality preservation for harvested biomass. The objective of this study was to investigate the effects of different light emitting diodes (LED) spectra (green, red, blue, and white LED) alone or in combination with 1-Methylcyclopropene (1-MCP) on postharvest quality and bioactive compounds of cucumber fruit during cold storage for 16 days at 5°C, the control fruit were left in the dark. For combined treatment, the fruits were exposed to 1-MCP …

Control And Entrainment Of Oscillatory Dynamics In An Oncolytic Virus–Tumor Model Under Periodic Therapy Forcing, Aya Salaheddin Shujrawi

Theses

This thesis investigates the dynamics of a tumour–virus interaction model under sinusoidal periodic viral injection, using the three-compartment ordinary differential equation framework of Baabdulla and Hillen (2024). The aim is to characterise how the frequency and amplitude of periodic injection interact with the system's intrinsic oscillatory dynamics, and to identify conditions for stable frequency entrainment. Equilibrium and Hopf bifurcation analysis of the autonomous system yields a supercritical bifurcation at θ_H^auto ≈ 338.45 with intrinsic frequency Ω₀^auto ≈ 0.7552. Introducing a constant baseline injection u₀ = 0.05 raises the threshold to θ_H^forced ≈ 364.85 and shifts …

La Espiritualidad: Transmitting Peruvian Culturo-Spiritual Elements Into Occidental Systemic Spaces, Deisy Amorin-Woods

Research outputs 2022 to 2026

This paper is a decolonising, Indigenous qualitative inquiry that integrates elements of critical autoethnography, narrative methods and conceptual analysis to explore how Peruvian Andean cosmology can inform contemporary systems thinking and family therapy practice. Writing as a mestiza, a Peruvian migrant in Australia, the author traces the lived experience of cultural erosion within Western, individualistic contexts and her reconnection with ancestral Andean teachings. These teachings—rooted in reciprocity, ecological attachment, collective responsibility and relational balance—are presented as living epistemologies that offer timely contributions to working therapeutically. The author examines core Andean concepts including ayll (kinship-based community), ayni (sacred reciprocity), Yachay (aprenderes …

Precision Nutrition In Breast Cancer: Towards Patient- And Tumour-Informed Dietary Strategies, Cristina Crespo-García, R. Taaffe, Carolyn Peddle-Mcintyre, Emily Jeffery, John P. Campbell, Robert Thomas, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Dietary strategies are increasingly recognized as important modulators of breast cancer outcomes, acting through effects on metabolic regulation, weight management, hormone signalling, immune function, and the gut microbiome. However, breast cancer heterogeneity and inter-individual variability mean that generic dietary guidelines may not fully capture patient needs. Precision nutrition offers the opportunity to align dietary interventions with tumour subtype, treatment context, and host biology, potentially enhancing therapeutic response and survivorship in patients diagnosed with breast cancer. In this narrative review, we summarize evidence on dietary patterns and prognosis, and explore how targeted interventions, including fasting regimens, ketogenic diets, and caloric restriction, …

Engineering Immunity? Biotechnical Governance And The Experimental Failures Of Project Wolbachia In Singapore, Siew Ying Shee, Orlando Woods, Sayd Randle

Research Collection School of Social Sciences

This paper introduces the idea of ‘experimental failure’ to critically interrogate the limits of engineering biological systems for urban governance. Whilst experimentation through projects related to smart cities and eco-cities has garnered significant attention, biotechnical experiments––which manipulate living organisms through technology––remain underexplored. Unlike interventions leveraging non-living, inanimate systems, engineering life must contend with ecological ‘unruliness’ and social uncertainties. These complexities often resist straightforward quantification and exceed conventional evaluation frameworks, demanding a rethinking of what constitutes ‘success’ and ‘failure’ in such interventions. Drawing on ethnographic research with public health officers, pest management professionals and residents in Singapore, we analyse the government-led …

The Emerging Roles Of Ai In Self-Directed Stress Management: Systematic Review, Mary Kamillah Grace Reyes, Shauna Sha Min Teo, Andree Hartanto

Research Collection School of Social Sciences

Background: Stress is widespread and carries substantial mental health, social, and economic burdens. Yet, access to clinician-led stress management remains constrained by service capacity, cost, and stigma. In response, artificial intelligence (AI)–enabled tools have rapidly proliferated as scalable, self-directed options. However, evidence on how these systems support stress management outside formal clinical settings remains fragmented. Objective: This systematic review aimed to synthesize empirical evidence on how AI-enabled technologies are used for self-directed stress management. We mapped the emerging functions of these tools, the psychological frameworks informing their design, the populations and settings studied, and the outcomes reported. Methods: We conducted …

Benchmarking Gaslighting Negation Attacks Against Multimodal Large Language Models, Bin Zhu, Yinxuan Gui, Huiyan Qi, Jingjing Chen, Chong-Wah Ngo, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

Multimodal Large Language Models (MLLMs) have exhibited remarkable advancements in integrating different modalities, excelling in complex understanding and generation tasks. Despite their success, MLLMs remain vulnerable to conversational adversarial inputs. In this paper, we systematically study gaslighting negation attacks—a phenomenon where models, despite initially providing correct answers, are persuaded by user-provided negations to reverse their outputs, often fabricating justifications. We conduct extensive evaluations of state-of-the-art MLLMs across diverse benchmarks and observe substantial performance drops when negation is introduced. Notably, we introduce the first benchmark GaslightingBench, specifically designed to evaluate the vulnerability of MLLMs to negation arguments. GaslightingBench consists of multiple-choice …

June 2026 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Age-Related Increase In Plasma P-Tau217 In Amyloid-Beta–Negative Cognitively Unimpaired Individuals Affects Diagnostic Interpretation, Anna E. Mammel, Fernando Gonzalez-Ortiz, Ali Mousavi, Kelsey Hallett, Mary Encarnacion, Don Biehl, Pradip Gill, Sazan Ismael, Christopher Fowler, James D. Doecke, Larry Ward, Hans Frykman

Research outputs 2022 to 2026

Introduction: The extent to which non-pathological aging influences plasma biomarkers remains unclear. Here, we investigate factors influencing plasma p-tau217 levels in cognitively unimpaired (CU), amyloid-beta–negative (Aβ-) individuals. Methods: Plasma p-tau217 was measured in CU Aβ- positron emission tomography–negative (PET-) participants using two immunoassays (ALZpath n = 360 and LUMIPULSE G1200 n = 73). Associations between p-tau217 and age groups (60–69, 70–79, and 80+ years), apolipoprotein E (APOE) genotype, and gender were evaluated. Results: ALZpath plasma p-tau217 showed a non-pathological age-related increase (p < 0.001), and increased percentage within the intermediate zone with age. Lumipulse p-tau217 showed an increase in the percentage of subjects with positive results with age, however, this trend was not significant (p > 0.05). Men had higher levels of p-tau217 only with the ALZpath assay (p = 0.02; Lumipulse: p = …

Evidence For Direct And Sleep-Moderated Relationships Between Aquaporin-4 Genetic Variants And Alzheimer's Disease Phenotypes, Tenielle Porter, Ayeisha Milligan Armstrong, Eleanor K. O'Brien, Vincent Doré, Pierrick Bourgeat, Mitchell Turner, Paul Maruff, Christopher C. Rowe, Belinda M. Brown, Victor L. Villemagne, Stephanie R. Rainey-Smith, Simon M. Laws

Research outputs 2022 to 2026

Introduction: Variants in the aquaporin-4 gene (AQP4) have been associated with Alzheimer's disease (AD) diagnosis, cognition, and brain amyloid beta (Aβ) and may affect the sleep and Aβ relationship. Their association with other AD-related phenotypes/disease progression remain largely unknown. Methods: Associations between AQP4 variants, self-reported sleep measures, and AD-related phenotypes in cognitively unimpaired individuals with evidence of Aβ accumulation were examined using data from the Australian Imaging, Biomarkers and Lifestyle study. Results: AQP4 variants were directly associated with regional brain volumes, atrophy, and cognition. They were also associated with differences in regional brain volumes and atrophy in interaction with sleep …

Numerical Evaluation Of A Zero Poisson’S Ratio Structure In Μ-3d-Printed Self-Expanding Nitinol Stents, Farhana Yasmin, Ana Vafadar, Majid Tolouei-Rad

Research outputs 2022 to 2026

Stenting is a minimally invasive treatment used in managing peripheral artery disease (PAD). However, clinical challenges persist, including in-stent thrombosis and restenosis, primarily driven by axial foreshortening or elongation and suboptimal balance between radial stiffness and flexibility inherent to conventional stent designs. This study proposes an innovative arrow-shaped geometry exhibiting zero Poisson’s ratio (ZPR) behaviour for 3D-printed self-expanding Nitinol stents. The complete stent deployment process was modelled using finite element analysis (FEA), including radial crimping and subsequent expansion to enable systematic parametric investigation while accounting for µ-3D printing constraints. Response surface methodology (RSM) rigorously evaluated mechanical performance, defining peak stress, …

Sporadic Appetites: Unearthing The Fungal Diets Of Two Mycophagous Mammals Across An Australian Climate Gradient, Rebecca J. Quah, Saul J. Cowen, Robert A. Davis, Harriet R. Mills, Anna J.M. Hopkins

Research outputs 2022 to 2026

Translocating threatened ecosystem engineers may offer the dual benefit of contributing to species conservation and ecosystem restoration. Boodies (burrowing bettong; Bettongia lesueur) and woylies (brush-tailed bettong; Bettongia ogilbyi) are threatened mycophagous marsupials known for their crucial role in ecosystem health through fungal dispersal and bioturbation. As part of restoration efforts across Australia, these bettong species are frequently targeted for translocations, where a better understanding of their fungal dietary requirements is essential for ensuring their resource requirements are met and in predicting their ecological contributions to recipient ecosystems. Here, we used DNA metabarcoding to study the fungal diets of boodies and …

The Effect Of Boosting Dietary Lactobacillus And Phytochemical Rich Foods On Biomarkers Of Longevity—A Phase Ii Randomised Placebo Controlled Trial, Robert J. Thomas, Madeleine Williams, Jeffrey W.F. Aldous, Stacey A. Kenfield, Robert U. Newton

Research outputs 2022 to 2026

As men age, systemic inflammation increases, whereas grip strength (GS) and testosterone levels tend to fall. This rate of decline is known to be influenced by gut microbial health, lifestyle and diet but the role for interventions to slow this decline are less well established. This double-blind randomised controlled trial evaluated the impact, and explored the synergistic potential, of boosting phytochemical rich foods and Lactobacillus probiotics on these physical and biological markers. Two hundred and eight men with untreated early prostate cancer managed with observation only (average age 74 years) received a phytochemical rich supplement (PRS) containing concentrated broccoli, green …

The Life Study: A Cross-Sectional Study Protocol For Lifestyle Risk Factors For Chronic Disease Across The Stages Of Reproductive Ageing, Laura E. Pernoud, Jamie L. Noll, Paul A. Gardiner, Melinda Dean, Kathryn M. Broadhouse, Meegan Anne Walker, Hattie H. Wright, Anthony Villani, Joseph Scott, Alexandra P. Metse, Mia A. Schaumberg

Research outputs 2022 to 2026

Introduction: The dynamic physiological and hormonal changes through the menopause transition predispose women to an increased risk of chronic diseases including cardiovascular disease, metabolic disease, depression and dementia. The underlying mechanisms remain unclear, yet it is thought that chronic systemic inflammation and changes to lifestyle behaviours play important roles. The LIfestyle risk Factors for chronic disease across the stagEs of reproductive ageing (LIFE study) is a cross-sectional study aimed to characterise how hormonal and lifestyle (physical activity, diet and sleep) differences across pre, peri and postmenopause influence chronic systemic inflammation, visceral adiposity, cognitive function and sleep health. Methods and analysis: …

Detection And Evaluation Of Hazardous Mercury Contamination In Various Biological Samples, Krish Italiya

Biochemistry and Molecular Biology

Mercury is a toxic environmental pollutant that threatens ecosystems and human health. This study investigates mercury contamination in Lactuca sativa (lettuce) and selected fish species, including tuna and salmon, focusing on plant responses and the limitations of X-ray fluorescence (XRF) analysis. In a controlled experiment, lettuce plants were exposed to mercury to evaluate uptake and toxicity, and XRF spectroscopy was used for quick, non-destructive elemental analysis. Results confirmed mercury accumulation in lettuce, along with visible stress symptoms such as leaf yellowing, purple pigmentation, and tissue damage. Mercury was not detected in tuna and salmon samples, likely due to concentrations below …

Screening Tools For Maternal Mental Health In Africa: A Systematic Review, Joyce Jebet, Irene Mageto, Benard Mutwiri, Abednego Ongeso, Ruth Wagathu, Rose Maina, Denis Munene, Kawira Kithuci, Peter Gatiti

School of Nursing & Midwifery, East Africa

Background:

Maternal health during pregnancy and the postnatal period encompasses mental health, which is a key aspect in enhancing a positive outcome. Despite screening for other possible complications during pregnancy and the postnatal period, very little attention has been paid to screening for mental health. Screening is a key tool in early diagnosis and, eventually, timely diagnosis and management in cases where complications arise.

Aim:

This study aimed to assess the available maternal mental health screening tools and compare the outcome on their utilization during pregnancy and postnatal periods in the African continent.

Methodology:

This was a …

Investigating The Effects Of Increased O-Glcnaylation On Pathology In Alzheimer’S Disease, Melissa Louise Garcia

ETDs from 2020-2029

Alzheimer’s disease (AD) is currently the 7th leading cause of death, with few treatment options. It is known that AD pathology begins 20-30 years before clinical symptoms manifest. Some of the earliest pathological changes occur in glial cells of the hippocampus, causing them to become chronically reactive, as well as the accumulation of Amyloid-β (Aβ) in the hippocampus and hyperphosphorylated Tau (pTau) in the locus coeruleus, resulting in dysfunction of the noradrenergic (NA) system. Preclinical studies have shown promise in the abilities of the post-translational modification O-linked β-N-acetylglucosamine (O-GlcNAc). O-GlcNAc is a tightly regulated reversible enzymatic modification controlled by the …

Elucidating The Role Of The Rnf20 Histone Modifier In Pancreatic Beta Cells, Tanya Hans Pierre

ETDs from 2020-2029

Diabetes is defined as a loss of functional beta cell mass. It is classically categorized into Type 1 Diabetes (T1D), immune-mediated beta cell destruction and Type 2 Diabetes, which is characterized by whole body insulin resistance alongside beta cell dysregulation. The incidence of diabetes worldwide has risen annually. Despite the presence of therapeutic interventions, diabetes’ heterogeneity can prompt ineffective glycemic control and the development of diabetes-associated comorbidities. For that reason, new approaches to glycemic control for individuals with diabetes are required. One approach to restore glucose homeostasis is beta cell replacement therapy, in which stem cells are programmed into beta-like …

The Association Of Motherhood And Maternal-Related Life Events And Cardiovascular-Related Health, Disease Events, And Mortality, Taishayla Mckitt

ETDs from 2020-2029

More than 40% of U.S. women have cardiovascular disease (CVD), and nearly half have at least one major risk factor. Sparse evidence exists related to the role of childrearing (regardless of prior pregnancy) on CVD. A recent literature review highlighted the influence of reproduction on CVD and health and identified opportunities for advancement. At present, it has yet to be discovered from prospective epidemiologic studies the extent to which parenting and maternal events have influence on cardiovascular health and clinical events. It has been demonstrated that parous women have greater prevalence of cardiovascular risk factors (e.g., short sleep duration and …

Balancing Act: How Graduate Student Mothers Navigate Dual Roles, Jessica Seymour

ETDs from 2020-2029

Graduate student mothers represent a growing but often overlooked population within higher education. While research has examined the experiences of undergraduate student parents, significantly less attention has been given to graduate students who balance academic responsibilities with motherhood. This study explores the experiences of graduate student mothers enrolled at public four-year institutions, focusing on the institutional, financial, and social barriers that shape their academic success and participation in campus life. Using a phenomenological approach, this research seeks to understand how graduate student mothers navigate the dual roles of parenting and pursuing advanced degrees. The study employs a Borderland Theoretical Framework …

Comparative Evaluation Of Translucency, Fluorescence, And Structural Analysis Of 3d-Printed Vs. Conventionally Fabricated 3y, 4y And 5y Zirconia, Surabhi Chhabra

ETDs from 2020-2029

Statement of Problem: Additive manufacturing has emerged as an alternative to conventional milling for zirconia-based dental restorations because of its potential to reduce material waste and increase design flexibility. However, whether 3D-printed zirconia can provide optical and structural properties comparable with those of conventionally milled zirconia for esthetic applications remains unclear. Purpose: The purpose of this in vitro study was to compare the optical properties of 3D-printed zirconia and conventionally milled 3Y, 4Y, and 5Y zirconia, as measured by translucency and fluorescence, and to evaluate their structural characteristics, as measured by density, porosity, phase composition, and surface morphology. Materials and …

Recognizing Patients In Places: A Multilevel Analysis Of Severe Heat-Related Illness Risk In Birmingham, Al, Andria Cimino

ETDs from 2020-2029

Socially marginalized people face a higher risk of adverse health outcomes from extreme heat—as many as 12,000 U.S. deaths a year are attributable to heat-related illness (HRI), a preventable but multifactorial condition. Where one lives plays a critical role in HRI incidence, with evidence linking historically segregated and disinvested urban environments to a higher risk. The literature also suggests that Black adults experience worse HRI outcomes than non-Hispanic White adults, and that men are often, though not always, at higher risk than women. Individuals with heat-sensitive conditions and socially isolated adults also face elevated risk. Yet the mechanisms by which …

Protein Glycosylation In Natural And Synthetic Minimal Genome Mycoplasmas, John Sanford

ETDs from 2020-2029

Mycoplasmas are cell wall-less bacterial symbionts with remarkably streamlined genomes. Mycoplasmas offer two intriguing model organisms for studying concepts of minimal life. Mycoplasma genitalium has streamlined its genome to 580-kbp while maintaining virulence to suit its niche of parasitizing the human urogenital tract. The J. Craig Venter Institute has synthesized and transplanted a 543-kbp genome into a recipient cell, resulting in a non-pathogenic organism termed JCVI-syn3A. The conservation of a biological process in M. genitalium and JCVI-syn3A strongly implies an essential function in mycoplasmas, and potentially all life. Despite common thought of mycoplasmas being the simplest cells, much of their …