Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (4124)
- Medicine and Health Sciences (4120)
- Social and Behavioral Sciences (2142)
- Physical Sciences and Mathematics (2108)
- Medical Sciences (1266)
-
- Education (1225)
- Arts and Humanities (1192)
- Medical Specialties (1116)
- Engineering (928)
- Plant Sciences (889)
- Biology (799)
- Earth Sciences (775)
- Psychology (774)
- Plant Biology (641)
- Agronomy and Crop Sciences (637)
- Agricultural Science (632)
- Soil Science (609)
- Law (604)
- Weed Science (590)
- Plant Pathology (587)
- Public Health (535)
- Environmental Sciences (440)
- Ecology and Evolutionary Biology (439)
- Animal Sciences (402)
- Chemistry (379)
- Oncology (335)
- Higher Education (332)
- Diseases (322)
- Biochemistry, Biophysics, and Structural Biology (310)
- Sociology (310)
- Institution
-
- The Texas Medical Center Library (863)
- University of Kentucky (816)
- University of Texas at Arlington (454)
- Liberty University (413)
- Arkansas State University (317)
-
- Thomas Jefferson University (311)
- TÜBİTAK (286)
- Old Dominion University (273)
- Technical Disclosure Commons (263)
- Walden University (247)
- Universitas Indonesia (246)
- University of Technology (243)
- University of Montana (241)
- Nova Southeastern University (234)
- University of Texas Rio Grande Valley (223)
- University of Arkansas, Fayetteville (219)
- University of Plymouth (214)
- Utah State University (213)
- University of Al-Qadisiyah (207)
- Edith Cowan University (202)
- Washington University School of Medicine (196)
- University of Central Florida (179)
- University of South Carolina (179)
- Universitas Padjadjaran (174)
- Design Research Society (168)
- Journal of Dental Sciences (166)
- City University of New York (CUNY) (162)
- Brigham Young University (155)
- University of Baghdad (155)
- Duquesne University (149)
- Keyword
-
- Humans (840)
- Female (490)
- Male (439)
- Animals (341)
- Mice (225)
-
- Middle Aged (214)
- Adult (183)
- Aged (161)
- ICTS (Institute of Clinical and Translational Sciences) (154)
- Biomarkers (119)
- Artificial intelligence (115)
- Biology (115)
- Child (113)
- Machine learning (108)
- Engineering (100)
- Adolescent (94)
- Mental health (87)
- Climate change (85)
- Inflammation (85)
- Education (84)
- Depression (74)
- Cancer (71)
- United States (70)
- Tumor (68)
- Stress (66)
- Anxiety (65)
- Science (64)
- Young Adult (63)
- Obesity (62)
- Signal Transduction (62)
- Publication
-
- IGC Proceedings (1977-2023) (571)
- Theses and Dissertations (378)
- Faculty, Staff and Student Publications (369)
- Faculty, Staff and Students Publications (350)
- The Shorthorn Newspaper Collection: 1980s (286)
-
- All Approved Curriculum (270)
- Doctoral Dissertations and Projects (265)
- Defensive Publications Series (263)
- Engineering and Technology Journal (243)
- Walden Dissertations and Doctoral Studies (226)
- Al-Qadisiyah Medical Journal (207)
- Honors Theses (195)
- 2020-Current year OA Pubs (190)
- Research outputs 2022 to 2026 (190)
- Electronic Theses and Dissertations (187)
- DRS Biennial Conference Series (156)
- Journal of Dental Sciences (152)
- Baghdad Science Journal (140)
- Undergraduate Student Symposium (139)
- Jurnal Ilmu Ternak Universitas Padjadjaran (137)
- Food and Machinery (136)
- Creative Nonfiction Magazine (126)
- Faculty Publications (126)
- Dissertations (118)
- Theses (108)
- Masters Theses (102)
- Master's Theses (101)
- Manuscripts, Articles, Book Chapters and Other Papers (95)
- All Graduate Theses and Dissertations, Fall 2023 to Present (89)
- Liberty University Research Week (86)
- Publication Type
Articles 4501 - 4530 of 18657
Full-Text Articles in Entire DC Network
Case Study On Operational Performance Improvement By Turbocharger Nozzle-Ring Modification In Shipboard Generators, Jong-Hun Im, Mukyeong Kang, Sang-Deuk Lee
Case Study On Operational Performance Improvement By Turbocharger Nozzle-Ring Modification In Shipboard Generators, Jong-Hun Im, Mukyeong Kang, Sang-Deuk Lee
Journal of Marine Science and Technology–Taiwan
Owing to increasingly stringent emission regulations imposed by the International Maritime Organization and rising fuel prices, the demand for enhanced energy efficiency and emission control in marine power systems is increasing. This study presents a case study in which the performance of an aging auxiliary generator is restored by modifying the turbocharger nozzle ring. The vessel, a 12-year-old crude-oil tanker, experienced repeated operational issues with its No. 3 generator. This included elevated exhaust gas temperatures, reduced intake air pressure, and frequent turbocharger surges. To address these challenges, the nozzle-ring blade angle was reduced by approximately 2° using spare components, while …
Towards Sustainable Marine Education: Assessing High School Students’ Understanding Of Conservation Concepts, Cheng-Chieh Chang, Tsuyoshi Sasaki, Ya-Yin Liao, Ling-Ya Hung, Liang-Ting Tsai
Towards Sustainable Marine Education: Assessing High School Students’ Understanding Of Conservation Concepts, Cheng-Chieh Chang, Tsuyoshi Sasaki, Ya-Yin Liao, Ling-Ya Hung, Liang-Ting Tsai
Journal of Marine Science and Technology–Taiwan
This study assesses the concepts of marine resource conservation and sustainability among Taiwanese high school students by developing a Chinese version of the Marine Resources Conservation and Sustainability Scale. Grounded in the cognitive, socio-emotional, and behavioral learning objectives outlined in UNESCO’s Education for Sustainable Development Goals (ESDGs), the scale targets students aged 16 to 18 to examine gender differences in marine knowledge and conservation concepts. The scale comprises 31 items across four dimensions: the first section evaluates marine knowledge, while the remaining dimensions utilize a four-point Likert scale to assess cognitive, socio-emotional, and behavioral learning objectives, respectively. The results indicate …
Dynamic Governance Of Transboundary Fisheries Through Deep Learning And High-Frequency Vessel Tracking Data For Climate-Resilient Management: An Application To The East China Sea, Qin Lin, Yaqing Shu, Manel Grifoll, Hongxiang Feng
Dynamic Governance Of Transboundary Fisheries Through Deep Learning And High-Frequency Vessel Tracking Data For Climate-Resilient Management: An Application To The East China Sea, Qin Lin, Yaqing Shu, Manel Grifoll, Hongxiang Feng
Journal of Marine Science and Technology–Taiwan
Transboundary fisheries governance is increasingly challenged by jurisdictional conflicts, regulatory asymmetries, and climate-induced stock shifts in fish stocks, especially in contested regions like the East China Sea (ECS). This study capitalizes on China’s high-frequency BeiDou Navigation Satellite System (BDS) data (June 2021–May 2022) to pioneer a CNN-BiLSTM deep learning model to dynamically identify fishing hotspots and evaluate policy effectiveness. By integrating vessel trajectories, environmental variables, and regulatory events, we examine spatiotemporal patterns of fishing effort relative to seasonal bans, extreme weather, and quota systems. Key findings reveal: (1) post-moratorium (September–December) concentration of fishing intensity, peaking in November; (2) significant weather-driven …
Lock Scheduling Decisions And Strategy Optimization Under Operation Interruption Scenarios, Junhe Li, Qiang Zhang, Junpeng Jiang, Jiangchao Bao
Lock Scheduling Decisions And Strategy Optimization Under Operation Interruption Scenarios, Junhe Li, Qiang Zhang, Junpeng Jiang, Jiangchao Bao
Journal of Marine Science and Technology–Taiwan
Locks are critical nodes in inland waterway transportation systems that concentrate vessel traffic between upstream and downstream reaches, making their operations highly sensitive to hydrological conditions. Therefore, disruptions caused by droughts, floods, or routine maintenance can easily trigger congestion. To address this issue, this study systematically examines the interrelationships among the number of ships awaiting passage, scheduling strategies, the trade-off between lock chamber utilization and ship waiting time, the influence of ship entry sequences on user satisfaction, and the combined effects of these factors on overall lock scheduling performance. Based on these analyses, an integrated decision-making model for two-stage ship …
Corrosion Protection Assessment Of Offshore Wind Turbine Substructures Using Beasy Cp Simulation Analysis, Chuan-Yang Wan, Hung-Hua Sheu, Sheng-Yu Wang, Yao-Ming Wang, Wei-De Chen, Ming-Yuan Lin, Hung-Bin Lee
Corrosion Protection Assessment Of Offshore Wind Turbine Substructures Using Beasy Cp Simulation Analysis, Chuan-Yang Wan, Hung-Hua Sheu, Sheng-Yu Wang, Yao-Ming Wang, Wei-De Chen, Ming-Yuan Lin, Hung-Bin Lee
Journal of Marine Science and Technology–Taiwan
This study investigates the corrosion protection assessment of offshore wind turbine substructures established in the waters off Keelung, Taiwan. First, a cathodic protection system for the monopile foundation is designed and established. The Boundary Element Method (BEM) is applied using the BEASY simulation software to develop a 3D geometric model for cathodic protection. In the steel monopile simulation analysis, the exposed marine environment is set based on the sea conditions of the Keelung small boat marina, including parameters such as salinity, resistance, and polarization curves, to establish an effective cathodic protection system for underwater structures. By simulating these parameters, a …
Face-To-Face Versus Distance Education In Competence-Based Maritime Education And Training, Clara Borén, Marcella Castells-Sanabra, Manel Grifoll
Face-To-Face Versus Distance Education In Competence-Based Maritime Education And Training, Clara Borén, Marcella Castells-Sanabra, Manel Grifoll
Journal of Marine Science and Technology–Taiwan
The COVID-19 pandemic created significant challenges for higher education, with universities being shut down and face-to-face teaching and assessment shifting to an online format. This presented an opportunity to focus on the continuity of learning through distance education, especially in the maritime context, due to the on-board training requirements, and even though five years have passed, this shift has reshaped the education landscape, proving that remote learning has come to stay.
At the Barcelona School of Nautical Studies, we have developed a weather routing software in the framework of distance education and teaching innovation. We conducted a teaching trial alternatively …
A Bibliometric And Visualization Analysis Of Global Giant Clam Research, Chia-Hsiang Chen, Chih-Hsien Chang
A Bibliometric And Visualization Analysis Of Global Giant Clam Research, Chia-Hsiang Chen, Chih-Hsien Chang
Journal of Marine Science and Technology–Taiwan
In this study, bibliometric analysis and visualization tools were used to investigate the academic network and knowledge structure surrounding global giant clam research. A total of 551 relevant publications from the Web of Science database, published from 1900 to 2024, were analyzed. The findings indicate that research on giant clams has experienced considerable growth since 2012, peaking in publication output in 2021. Sixty-six countries were represented in the study sample, with the United States, Australia, China, Singapore, and Japan being the most represented ones. Notably, the rate of international collaboration was only 29%, highlighting a need for additional integrated cross-border …
(Re)Claiming Homeplace: Dance As Embodied Resistance & Healing For Health & Spatial Justice, Preeya G. Kannan
(Re)Claiming Homeplace: Dance As Embodied Resistance & Healing For Health & Spatial Justice, Preeya G. Kannan
University Honors Theses
This thesis argues that dance functions as both an upstream public health intervention and a form of radical spatial resistance; creating healing, agency, and belonging among historically marginalized communities. Drawing on bell hooks' concept of homeplace, Jasbir Puar's assemblage theory, Nancy Krieger's eco-social theory, and Katherine McKittrick's Black geographies, I position the body as both an ecological and political landscape shaped by histories of colonialism, racial capitalism, displacement, and resilience.
Through this community-based participatory research study, Homeplace, I explore dance as a form of social prescription that centers liberation rather than pathology. Movement is often reduced in public health discourse …
The Human Side Of Humanitarian Work: Well-Being And Performance Among Aid Workers In Egypt, Mai Osama Kenawy
The Human Side Of Humanitarian Work: Well-Being And Performance Among Aid Workers In Egypt, Mai Osama Kenawy
Theses and Dissertations
Well-being and productivity are widely recognized as central to the work performance of humanitarian aid workers. Despite increasing attention to staff well-being, performance within the humanitarian sector in Egypt remains stagnant or, in some cases, declining. This study examines why expanded well-being initiatives have not yielded sustained performance improvements by examining how actors' external roles, organizational factors, and individual factors affect humanitarian workers’ well-being and work performance. A mixed-methods approach was adopted, combining ten in-depth interviews with humanitarian workers from international organizations, INGOs, and local NGOs, as well as a survey of eighty workers operating in the same context. The …
2026-06-15 Message From The President, Morehead State University. Office Of The President.
2026-06-15 Message From The President, Morehead State University. Office Of The President.
Staff Congress Records
Message sent on June 15, 2026 by the President to the campus community regarding modified hours, upcoming dates of importance, Board of Regents meeting summary, and campus personnel announcements and updates.
The Experience Of Newly Formed Syrian Female-Headed Households Refugees In Egypt: Challenges And Opportunities, Wasim Dia
Theses and Dissertations
This thesis examines the lived experience of Newly Formed Syrian Female-Headed Households in Egypt. It focuses on how the extended displacement reshapes gender roles, decision-making, and survival strategies. Since the beginning of the Syrian conflict in 2011, extensive family separation, death, disappearance, and male migration have occurred, leading to a significant rise in female-headed Syrian refugee households. As a result, displacement has intensified women’s vulnerability, generating new responsibilities and limited spaces for agency, especially within restrictive legal and socio-economic environments.
Based on in-depth qualitative interviews conducted in 2023, this research explores how Syrian refugee women navigate everyday life in Egypt …
“Between Cultural Norms And Economic Survival: Navigating Egyptian Lower And Middle Income Women’S Challenges In The Informal Versus The Formal Work: “A Case Study From Cairo”, Rowan Mahmoud Abdelnazer
“Between Cultural Norms And Economic Survival: Navigating Egyptian Lower And Middle Income Women’S Challenges In The Informal Versus The Formal Work: “A Case Study From Cairo”, Rowan Mahmoud Abdelnazer
Theses and Dissertations
This study investigates the ongoing gender inequities experienced by low and middle-income women in Egypt’s formal and informal labor economy, specifically it is based in Cairo. Although there are many advances made globally on women's rights, yet women still face great challenges such as discrepancies in salary, fewer leadership roles and cultural expectations which put child-bearing duties before professional growth. On the one hand, flexible work for women in developing countries is through informal sector, which makes them vulnerable and serves as a source of their exploitation and insecurity (e.g., lack of social security; workplace hazards), on the other hand, …
Proteomic Analysis Of Ammonia-Induced Stress In Chinese Hamster Ovary (Cho) Cell Cultures, David Ryan, Michael Henry, Christiana Kondylo Sideri, Esen Efeoglu, Paula Meleady
Proteomic Analysis Of Ammonia-Induced Stress In Chinese Hamster Ovary (Cho) Cell Cultures, David Ryan, Michael Henry, Christiana Kondylo Sideri, Esen Efeoglu, Paula Meleady
Research Outputs: 2025-Present
Ammonia (NH₃) and its ionic form ammonium (NH₄+) are both metabolic waste products and essential nitrogen sources within Chinese hamster ovary (CHO) cell cultures. Although necessary for amino acid synthesis, excessive accumulation in the extracellular environment can exert stress, reducing cell proliferation and impairing the efficiency of recombinant protein production. Proper endoplasmic reticulum (ER) function is critical for CHO cells as biotherapeutic producers. Previous work has linked elevated ammonia concentrations to reduced productivity via altered N-glycosylation pathways, but its broader effects on ER biology remain unclear. In this study, we applied high-resolution mass spectrometry to perform a comprehensive …
Integrative Assessment Of Body Composition And Micronutrient Status In An Adult Egyptian Population, Roua Aref Nouh
Integrative Assessment Of Body Composition And Micronutrient Status In An Adult Egyptian Population, Roua Aref Nouh
Theses and Dissertations
Integrative Assessment of Body Composition and Micronutrient Status in an Adult Egyptian Population: A Functional and Biochemical Approach
Obesity and metabolic dysfunction are increasingly recognized as heterogeneous conditions that cannot be sufficiently characterized by body mass index (BMI) alone. Alterations in body composition, particularly central adiposity and skeletal muscle mass, may coexist with micronutrient imbalances even among individuals who fall outside conventional BMI-based obesity classifications. In clinical settings, such metabolic vulnerability is frequently accompanied by non-specific functional symptoms, highlighting the need for integrative assessment approaches that extend beyond weight-centered metrics. This cross-sectional study aimed to investigate the associations between micronutrient …
Engineering Nanoelectrocatalytic Systems For Co2 And Nitrate Conversion Into Value-Added Chemicals, Abdelrahman Mohamed Abdelmohsen
Engineering Nanoelectrocatalytic Systems For Co2 And Nitrate Conversion Into Value-Added Chemicals, Abdelrahman Mohamed Abdelmohsen
Theses and Dissertations
The thesis addresses two major related environmental crises: nitrate pollution of water systems and the ever-increasing levels of atmospheric carbon dioxide. Both challenges are closely linked to anthropogenic disturbance of nitrogen and carbon cycles and require sustainable, energy efficient mitigation techniques. In this study, we investigate electrochemical conversion routes as a unified approach to convert these pollutants into value-added compounds: ammonia (NH3) via nitrate reduction (NO3-RR) and ethylene (C2H4) via carbon dioxide reduction (CO2RR). The first half of this work deals with the design and engineering of Cu-Zn alloy electrocatalysts for efficient NO3-RR. Tuning the alloy composition and surface nanostructure …
Sense Of Belonging Among Undergraduate Students At The American University In Cairo: Demographic Trends, Barriers And Facilitators, Lamiaa M. Mohamed
Sense Of Belonging Among Undergraduate Students At The American University In Cairo: Demographic Trends, Barriers And Facilitators, Lamiaa M. Mohamed
Theses and Dissertations
A sense of belonging is widely recognized as a key determinant of undergraduate students’ academic success, well-being, and persistence in higher education. However, existing research is largely grounded in Western contexts and often emphasizes institution-level measures, with limited attention to how belonging is experienced and constructed by students in non-Western settings. This study examines undergraduate students’ sense of belonging at the American University in Cairo, focusing on factors that shape belonging and institutional practices that may strengthen it. Using a sequential mixed-methods design, the study examined 87 responses from a quantitative survey adapted from the University Belonging Questionnaire, followed by …
Autophagic Flux Blockade Under Hypocapnia Reveals Co2-Sensitive Regulation Of Autophagy-Lysosome Homeostasis, Naghmana Ashraf, Zhen Sun, Jeanine L Van Nostrand
Autophagic Flux Blockade Under Hypocapnia Reveals Co2-Sensitive Regulation Of Autophagy-Lysosome Homeostasis, Naghmana Ashraf, Zhen Sun, Jeanine L Van Nostrand
Faculty, Staff and Students Publications
Hypocapnia, a reduction in partial pressure of carbon dioxide (CO2), commonly occurs in clinical contexts such as mechanical ventilation, panic disorder, and brain injury, yet its impact on cellular homeostasis remains poorly understood. Given the central role of autophagy in stress adaptation, we investigated how low CO2 influences autophagic flux and lysosomal function. We found that hypocapnia induces autophagosome accumulation while impairing cargo degradation, indicating a blockade in autophagic flux. This response was accompanied by increased lysosome biogenesis but, paradoxically, reduced autophagosome-lysosome fusion and lysosomal proteolytic activity. Mechanistically, hypocapnia promoted TFE3 dephosphorylation and nuclear translocation, driving transcriptional activation of lysosomal …
Ultrasound-Enabled Refreshable Electrochemical Sensors For Cardiac Biomarker Monitoring, Mayank Garg, Heng Guo, Myeong Namkoong, Elizabeth Zhanov, Connor Malone, Md Saifur Rahman, Ayse Akcan-Arikan, Limei Tian
Ultrasound-Enabled Refreshable Electrochemical Sensors For Cardiac Biomarker Monitoring, Mayank Garg, Heng Guo, Myeong Namkoong, Elizabeth Zhanov, Connor Malone, Md Saifur Rahman, Ayse Akcan-Arikan, Limei Tian
Faculty, Staff and Students Publications
Cardiac troponin I (cTnI) is the gold-standard biomarker for acute myocardial infarction, yet current laboratory-based high-sensitivity assays require centralized infrastructure, trained personnel, and serial testing, limiting their suitability for real-time or continuous monitoring in resource-limited settings. Point-of-care electrochemical sensors have shown promise for rapid cTnI detection, but their reliance on antibodies as biorecognition elements and redox mediator solutions, and single-use operation restricts practical translation. Here, we report an ultrasound-enabled refreshable electrochemical biosensor for sensitive, stable, and repeatable cTnI monitoring. The device employs a cTnI-specific peptide as the biorecognition element, providing enhanced stability during storage, transport, and operation. Label-free electrochemical impedance …
Macropinocytosis Inhibition Attenuates Profibrotic Responses In Lung Fibroblasts And Pulmonary Fibrosis Models, Ivan O Rosas, Aaron K Mcdowell-Sanchez, Santiago Sanchez, Juan D Cala-Garcia, Alan R Waich Cohen, Elisa Ruiz-Echartea, Scott A Ochsner, Daniel C Kraushaar, Lindsay J Celada, Dandan Sun, Francesca Polverino, Cristian Coarfa, Neil J Mckenna, Konstantin Tsoyi
Macropinocytosis Inhibition Attenuates Profibrotic Responses In Lung Fibroblasts And Pulmonary Fibrosis Models, Ivan O Rosas, Aaron K Mcdowell-Sanchez, Santiago Sanchez, Juan D Cala-Garcia, Alan R Waich Cohen, Elisa Ruiz-Echartea, Scott A Ochsner, Daniel C Kraushaar, Lindsay J Celada, Dandan Sun, Francesca Polverino, Cristian Coarfa, Neil J Mckenna, Konstantin Tsoyi
Faculty, Staff and Students Publications
Idiopathic pulmonary fibrosis (IPF) is a devastating chronic lung disorder with limited treatment options. Macropinocytosis is one of the key cellular processes involved in nutrient consumption from the extracellular environment under stress conditions. Here, we studied the role of macropinocytosis in experimental pulmonary fibrosis models. We found that macropinocytosis is increased in human lung fibroblasts (HLFs) derived from patients with IPF. The inhibition of macropinocytosis with 5-(n-ethyl-n-isopropyl)-amiloride (EIPA) inhibited profibrotic responses in IPF-derived and TGF-β1-stimulated HLFs and reduced pulmonary fibrosis in bleomycin-injured (Bleo-injured) mice. EIPA exerted its antifibrotic effects by regulating amino acid uptake, mammalian target of rapamycin complex 1 …
Exploring The Scales And Drivers Of Blue Transitions Of Marine Wild-Capture Fisheries To Mariculture In California, U.S.A, H. E. Froehlich, M. Rennick, R. R. Gentry, H. R. Lemoine, L. Gardner, S. E. Lester
Exploring The Scales And Drivers Of Blue Transitions Of Marine Wild-Capture Fisheries To Mariculture In California, U.S.A, H. E. Froehlich, M. Rennick, R. R. Gentry, H. R. Lemoine, L. Gardner, S. E. Lester
Faculty Research, Scholarly, and Creative Activity
Commercial capture fisheries worldwide are susceptible to perturbations and sudden declines, also known as shocks. While management reforms and diversification within wild fisheries have provided some stability, it is less clear how parallel sources of seafood production, such as aquaculture, fit into these dynamics, past and present. Marine aquaculture (mariculture) is one way to increase seafood supply as demand increases and fisheries landings potentially become more variable. This study examined historical trends in marine fisheries and mariculture in the state of California, U.S.A., with an aim to empirically understand local ‘blue transitions’, i.e. shifts from wild to farmed production. Using …
Personal Data Protection In Vietnam’S Burgeoning Insurance Sector, Thi Giang Thu Pham, Thị Long Nguyễn
Personal Data Protection In Vietnam’S Burgeoning Insurance Sector, Thi Giang Thu Pham, Thị Long Nguyễn
Washington International Law Journal
No abstract provided.
Lawrence University One Hundred Seventy-Seventh Commencement, Sunday, June 14, 2026, Lawrence University
Lawrence University One Hundred Seventy-Seventh Commencement, Sunday, June 14, 2026, Lawrence University
Commencement Programs
No abstract provided.
Baseline Lymphopenia Predicts Survival In Ici-Naïve Solid Tumor Patients Receiving Immune Checkpoint Inhibitors: A Propensity-Matched Real-World Pan-Cancer Analysis., Ahmed Ismail, Nina Balanchivadze, George R Simon, Yanis Boumber
Baseline Lymphopenia Predicts Survival In Ici-Naïve Solid Tumor Patients Receiving Immune Checkpoint Inhibitors: A Propensity-Matched Real-World Pan-Cancer Analysis., Ahmed Ismail, Nina Balanchivadze, George R Simon, Yanis Boumber
Oncology Articles
Background: Baseline lymphopenia is common among advanced solid tumors and may influence the efficacy/safety of immune checkpoint inhibitors (ICIs), but large real-world evidence is limited. We evaluated the association between baseline absolute lymphocyte count (ALC) and clinical outcomes in adults with solid tumors treated with ICIs in routine practice. Methods: We performed a retrospective cohort study using TriNetX. Adults with solid tumors who received pembrolizumab, nivolumab, or atezolizumab (ICI-Naïve) between January 2015 and June 2026 were included. Baseline ALC was measured within 30 days before first treatment and was classified as lymphopenic (ALC < 1.5 × 109/L) or non-lymphopenic (ALC ≥ 1.5 × 109/L). Propensity score matching (1:1) yielded 5249 patients per group. The index date was the first immunotherapy date, and outcomes were assessed at 6, 12, 24, 36 months, and 5 years. The primary outcome was 24-month overall survival (OS); secondary outcomes were OS at 6 and 12 months and 6-month risks of healthcare utilization, immune-related adverse events (irAEs), and serious infections; and exploratory outcomes included OS at 36 months and 5 years. All outcomes were analyzed using Kaplan-Meier analysis, Cox proportional hazards models, and risk ratios. Subgroup analysis included OS stratified by solid tumor subtypes and prior lines of therapy. Results: After matching, patients with baseline lymphopenia …
Making A Phrenological America: How The Science Of The Skull Influenced Reform Movements In The United States, Nathan C. Tamkin
Making A Phrenological America: How The Science Of The Skull Influenced Reform Movements In The United States, Nathan C. Tamkin
History Undergraduate Senior Theses
No abstract provided.
Destination “Burning River”: Restoration And Placemaking In A Rust Belt City, Mia Compton-Engle
Destination “Burning River”: Restoration And Placemaking In A Rust Belt City, Mia Compton-Engle
Geography Undergraduate Senior Theses
In 1969, the Cuyahoga River in Cleveland, Ohio caught fire from industrial pollution. Media narratives reframed the river fire as a symbol of environmental degradation, discursively transforming the Cuyahoga River from a place of industrial sacrifice to a place deserving ecological stewardship. Consequently, the river fire catalyzed the modern American environmental movement and local urban river restoration, materially transforming the Cuyahoga River from a place of industrial waste to a place of natural beauty and socioeconomic opportunity. Thus, urban river restoration presents an opportunity for novel placemaking: a local microcosm of the global turn towards urban sustainability. However, there is …
The Unspoken And The Unseen: An Analysis Of Victim Gender And Linguistic Framing Of Sexual Assault In Judicial Discourse, Sarnika Ali
Quantitative Social Science Undergraduate Senior Theses
Sexual assault is a profound legal and social crisis. However, it is also fundamentally a linguistic one. The words used, or conspicuously not used, to describe victims, perpetrators, and their actions are not neutral arbiters of fact. They are powerful mechanisms that shape perceptions of harm, attributions of blame, and assignments of credibility. The central battleground for survivors is credibility, and while a “credibility discount” is often applied to female victims, the male victim is rendered nearly invisible. This research is therefore guided by one central, overarching question: how does a sexual assault victim’s gender influence the judicial language used, …
Strategic Anti-Transgender Policy Diffusion: Interest Groups, Courts, And The Two-Track Politics Of Gender Regulation, Henry Danford
Strategic Anti-Transgender Policy Diffusion: Interest Groups, Courts, And The Two-Track Politics Of Gender Regulation, Henry Danford
University Honors Theses
This thesis analyzes the strategic diffusion of anti-transgender policy in the United States following the passage of Idaho House Bills 500 and 509 in 2020. It argues that conservative lawmakers and advocacy organizations employed a coordinated "two-track" policy strategy in which transgender sports bans served as highly visible and politically popular mode legislation while identity-document restrictions advanced more quietly through courts and administrative policy. Drawing on policy diffusion theory, the Advocacy Coalition framework, and minority stress theory, the study combines qualitative policy analysis with quantitative analysis of Household Pulse Survey mental health data and Media Cloud new coverage data from …
Elucidating The Function Of Yedk In Response To Dna Damage, Hank Munro
Elucidating The Function Of Yedk In Response To Dna Damage, Hank Munro
University Honors Theses
Apurinic/Apyrimidinic (AP) sites are one of the most prevalent forms of DNA damage. These lesions arise spontaneously or during base excision repair of modified DNA bases and are potentially mutagenic in both mammalian and bacterial cells. 5-hydroxymethylcytosine binding, ES cell specific (HMCES), a protein found in eukaryotic cells, has been shown to form a stable DNA-protein crosslink with AP sites in single stranded DNA and to reduce the number of AP sites occurring either spontaneously or after alkylative DNA damage, resulting in increased genome stability. YedK, the Escherichia coli ortholog of HMCES exhibits some of the same biochemical properties as …
Skeletons Vs. Mummies: Osteological Trauma On Bog Bodies As A Measure For Cultural Change In Ancient Europe, Miranda Hoodenpyl
Skeletons Vs. Mummies: Osteological Trauma On Bog Bodies As A Measure For Cultural Change In Ancient Europe, Miranda Hoodenpyl
University Honors Theses
Bog bodies are some of the most well known archaeological finds in the world, and are preserved human remains found in wetlands. Researchers use the information stored in the bones of bog skeletons and mummies to learn about cultural lifestyles, travels, diet, and diseases throughout time in Northern Europe and the British Isles. Through multiple cultural changes and migration, the "bog body phenomenon" has remained an unusual treatment displayed throughout time. This literature review looked at skeletal trauma on bog remains to identify cultural change over time in Northern Europe and the British Isles, spanning the Neolithic, Bronze, Iron, and …
Beyond The Best Prompt: A Coverage View Of Multilingual Reasoning, Harshiv Mistry
Beyond The Best Prompt: A Coverage View Of Multilingual Reasoning, Harshiv Mistry
University Honors Theses
Multilingual LLMs reason more accurately in English than in other languages, and recent work links part of this gap to reasoning behavior: native-language traces contain fewer cognitive behaviors (verification, backtracking, subgoal setting, backward chaining) that support effective problem solving. We test whether prompting for these behaviors at inference time narrows the gap, across seven conditions varying chain-of-thought, instruction and reasoning language, and cognitive-behavior descriptions, on two models, three languages. We find that English-scaffolded reasoning is the strongest single strategy on both models, closing the Hindi gap on Qwen, though the explicit scaffold's value over plain chain-of-thought is model-dependent. Beyond aggregate …