Digital Commons Network^™

Mobile Genetic Elements Shape Microbial Diversity And Functions In Thawing Permafrost Soils, Jiarong Guo, Samuel T. N. Aroney, Guillermo Domínguez-Huerta, Derek Smith, Dean Vik, Carlos Owusu-Ansah, Akbar Adjie Pratama, Sergei Solonenko, Funing Tian, Cristina Howard-Varona, Zhi-Ping Zhong, Aminata Fofana, Garrett J. Smith, Suzanne B. Hodgkins, Dylan Cronin, Isogenie Field Teams 2010–2017, 2019, Emerge Coordinators, Ben J. Woodcroft, Gene W. Tyson, Virginia I. Rich, Matthew B. Sullivan, Simon Roux, Sarah C. Bagby, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Ecosystems are shaped by communities of microorganisms whose niches and impacts depend on functional profiles influenced by gene gains and losses. Culture-based experiments demonstrate that mobile genetic elements (MGEs) can mediate gene flux, but quantitative understanding of these dynamics in natural systems remains limited. Here we develop and apply a systematic, meta-omic framework to investigate MGEs in a complex natural system using an 8-year soil time series collected at Stordalen Mire, in Sweden’s thawing permafrost margin. In this climate-critical peatland, we identify ~2.1 million MGE recombinases across 89 microbial phyla and assess ecological distributions, affected functions, past mobility and current …

Application Of Toast Criteria, Comorbidities And Outcomes In Patients With Ischemic Stroke: Multicenter Collaboration In The Dominican Republic, Ryna Then, Maria Muñoz, Cristina Ramos, Marcos Mota, Priscilla Sepulveda, Lisa José, Luis Suazo, Francisco Mendez, Yahaira Franco, Cosme González Villamán, Acela Gonell, Violiza Inoa, Gillian Gordon Perue, Manuel Colomé-Hidalgo, Nadja García

Einstein Health Papers

INTRODUCTION: Stroke is a leading cause of neurological-related death in the Caribbean. The Dominican Republic has among the highest stroke-related mortality rates in the Americas. We aimed to determine ischemic stroke etiologies, characterize comorbidities, and describe outcomes in the Dominican Republic using the TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification.

METHODS: We analyzed a multicenter quality registry between January 2022 and October 2024. Statistical analyses included Mann–Whitney U and Kruskal–Wallis tests with Bonferroni correction, chi-square tests, and Spearman correlation.

RESULTS: The most common stroke subtype was undetermined etiology (54.8%), followed by large artery atherosclerosis (17.2%) and cardioembolism …

Dietary Hermetia Illucens Larvae Meal Enhances Growth Performance, Intestinal Health And Modulates Intestinal Microbiota Of Juvenile Mirror Carp (Cyprinus Carpio), Sahya Maulu, Ben Eynon, Glenn Harper, Owen Day, Leona Emenike, Mark Rawling, Daniel Merrifield

School of Biological and Marine Sciences

As global aquaculture expands, sustainable alternative feed ingredients are needed to reduce reliance on fishmeal (FM) and conventional plant proteins. Herein, this study evaluated defatted black soldier fly (BSF; Hermetia illucens) larvae meal as a replacement mainly for soybean meal (SBM) and soy protein concentrate (SPC) in juvenile mirror carp diets. Fish (initial weight: 7.28 ± 0.09 g) were reared in a recirculating aquaculture system and fed for 8 weeks on either a control diet or diets containing 20% (BSF20) or 40% (BSF40) BSF meal. After the trial, growth performance was significantly improved in BSF-fed groups, with higher final weight, …

Cervical Insufficiency Revisited: A Proposal For A New Treatment-Aligned Definition, Vincenzo Berghella, Ilaria Paladino, Moti Gulersen, Rupsa Boelig, Amanda Roman

Department of Obstetrics and Gynecology Faculty Papers

Cervical insufficiency [CI] has traditionally been defined as painless cervical dilation resulting in recurrent second-trimester pregnancy loss in the absence of labor or placental pathology. Definitions from the American College of Obstetricians and Gynecologists and the Royal College of Obstetricians and Gynecologists emphasize historical clinical presentation. However, contemporary obstetrics relies increasingly on ultrasound-based cervical length surveillance and evidence-based cerclage indications rather than retrospective diagnosis. The objective of the review was to propose a definition of cervical insufficiency aligned with current evidence-based indications for mechanical prevention of preterm birth, i.e. cervical cerclage. In modern obstetric practice, the operational diagnosis of clinically …

Tusc3 Serves As A Rate-Limiting Gatekeeper Of A Glycan-Mediated Er Triage Checkpoint For Bmp4/Dpp, Antonio Galeone, Emilio Solazzo, Francesco Lavezzari, Seung Yeop Han, Gaia Consonni, Bruna My, Riccardo Rizzo, Giuseppe Gigli, Hamed Jafar-Nejad, Thomas Vaccari

Faculty, Staff and Students Publications

Trimming of the three glucose residues decorating nascent N-glycoproteins is a critical step for their entry into the endoplasmic reticulum quality control (ERQC) and recognition by ER chaperones. However, the functional relevance of the second glucose (G2) and the regulatory step upstream of its removal by glucosidase II (GCS2) remain poorly understood. Here, we report that TUSC3, a component of the oligosaccharyltransferase (OST) complex, regulates G2 to G1 trimming on N-glycosylated bone morphogenetic protein 4 (BMP4) and its Drosophila homolog Dpp to promote their ERQC entry. Loss- and gain-of-function genetic experiments and biochemical assays in mammalian cells and flies indicate …

Chemotherapeutic Induction Of Cytosolic Single-Stranded Dna Accumulation Sensitizes Triple-Negative Breast Cancer To Immunotherapy, Yong Du, Li Yang, Hui Dai, Jianli Zhou, Zhicheng Zhou, Ruoxi Yuan, Rui Ye, Anh Thai Quynh Nguyen, Kishor Bhatia, Shiaw-Yih Lin

Faculty, Staff and Students Publications

Background: Despite the widespread adoption of chemoimmunotherapy in triple-negative breast cancer (TNBC), the mechanisms by which cytotoxic chemotherapy engages antitumor immunity remain poorly defined. Identifying tumor-intrinsic immunogenic programs that predict and enhance responsiveness to immune checkpoint blockade (ICB) is therefore of critical clinical importance.

Methods: Transcriptomic signatures of TREX1 deficiency were generated from CRISPR-engineered TNBC models and applied to multiple independent TNBC cohorts treated with chemoimmunotherapy. Cytosolic single-stranded DNA (ssDNA) accumulation was quantified using a flow cytometry-based assay to functionally screen chemotherapeutic agents. Immune activation and therapeutic efficacy were evaluated using in vitro assays, syngeneic mouse tumor models, flow cytometry, …

Success Of Deuruxolitinib (Leqselvi™) In Extensively Treatment-Resistant Alopecia Universalis: A Case Report, Simona Kogan, Moises Lutwak, Daniel Lutwak, Tara Howard, Stanley Skopit, Sumeet Bhardwaj

Student Publications

Alopecia universalis (AU) is a severe autoimmune disorder characterized by complete loss of scalp and body hair. The introduction of Janus kinase (JAK) inhibitors has expanded therapeutic options for patients with severe disease; however, treatment responses remain variable, particularly among individuals with extensive and longstanding hair loss. Reporting cases with atypical or limited responses to therapy remains important for understanding the spectrum of clinical outcomes observed in practice.

We describe a 30-year-old man with a 23-year history of AU who demonstrated minimal response to multiple prior therapies, including tofacitinib (pan-JAK inhibitor) and ritlecitinib (JAK3/TEC inhibitor), without meaningful scalp, eyebrow, or …

Programmes That Integrate Parenting Support And Financial Well-Being Support: A Systematic Scoping Review, Eleanor F. Bryant, Morwenna Rogers, Amy Bond, Georgia Smith, Rebecca Summers, James Hall, Kristin Liabo, Iain Lang, Vashti Berry, Nick Axford

Peninsula Medical School

Childhood experiences of economic disadvantage have harmful and long-lasting effects on child health. Early intervention can reduce some harms but it is unclear whether addressing economic disadvantage alongside psychosocial support yields additional benefits. This systematic scoping review aimed to identify evaluated programmes that integrate parenting support (PS) and financial well-being support (FWbS) for parents of children aged 0–19. The objectives were to describe programmes, relevant components, evaluation designs and impact on outcomes, and to consider if any programmes merit replication and testing in a UK context. Outcome or implementation evaluations of integrated PS and FWbS programmes published in English were …

Gender Perspective(S): Lessons From International Human Rights Law To Defend Against Pregnancy Related Prosecutions, Megan Osadzinski

Northwestern Journal of Human Rights

The criminalization of pregnancy outcomes—such as miscarriages, abortion, obstetric emergencies, and stillbirth—is a violation of fundamental human rights guarantees; including the right to a fair trial when read in conjunction with the right to equality and the right to health. This article outlines state obligations under international human rights law toward women charged in pregnancy prosecutions, translating them into national criminal defense strategies using a gender perspective. Using intersectional theory, this article calls for the use of a gender perspective to challenge such prosecutions as unlawful gender-based discrimination and a gendered violation of due process, using the case study of …

Distribution And Transport Of Lithium Ions At Interfaces Between Graphite And Carboxymethyl Celluloses, Zi-Jun Huang, Zhen-Ying Zheng, Hua-Wei Cao, Jian Wang, Qing-Feng Zhang, Sheng-Li Chen

Journal of Electrochemistry

Carboxymethyl cellulose (CMC) is a water-processable binder widely used for graphite anodes. However, a microscopic understanding of why the identity of CMC counterions (Li⁺/Na⁺/K⁺) strongly affects electrode performance remains limited. Here, molecular dynamics (MD) simulations are used to track Li⁺ transport accessibility across electrolyte/CMC/graphite three-phase interfaces, comparing pure CMC-Li, CMC-Na, CMC-K, and mixed-counterion CMC binders. We find that CMC-Li sustains a continuous Li⁺ transport pathway from the electrolyte through the binder phase toward graphite. In contrast, in CMC-Na and CMC-K, Na⁺/K⁺ ions preferentially enrich at the graphite/binder interface, forming …

Crowd-Sourced Glacier Mapping As A Tool For Enhancing Climate Literacy And Data Generation, Caroline Clason, Sally Rangecroft, Shaun Lewin, Gina Kallis, Tom Mullier, Will Blake, Iain Stewart

School of Geography, Earth and Environmental Sciences

Citizen science approaches are increasingly used to support data generation and public engagement across the environmental sciences, yet their wider pedagogical value within physical geography remains underexamined. To explore the value of mapping-based citizen science for both glaciological investigation and geographical learning, we developed GlacierMap, an interactive online tool enabling participants to map glacier change in Peru’s Cordillera Blanca over a 34-year period. GlacierMap was designed not only to assess the feasibility and value of crowd-sourced glacier mapping, but also as a vehicle to support experiential learning of the trends in, and impacts of, tropical mountain glacier retreat. Participants mapped …

Two Decades Of Progress In The Prevention And Treatment Of Colorectal Cancer: From Aspirin To Targeted Therapy, Lovyanne Vergel De Dios, Salique Hassan Shaham, Puneet Vij, Manish Kumar Tripathi

School of Medicine Publications

No abstract provided.

Review Of: A Fragile Heritage: Untangling The Strands Of Faith And Mutation—Sheryl Leinbach, Beth Bennett, Karen Conley

Journal of Amish and Plain Anabaptist Studies

Get ready for an emotional roller coaster with parallel intellectual stimulation while reading Sheryl Leinbach’s A Fragile Heritage. Sheryl authentically describes the span of emotions and challenges faced by the mother of a child with Maple Syrup Urine Disease (MSUD), from birth through successful liver transplant. The book invites the reader to accompany the author on a journey of growing faith, intellectual expansion, and societal reflection as the family navigates through the turbulence of loving a notably broken child in a fallen world. [First paragraph.]

Life Writing Knowledge And Narrative Medicine : Creating The Transnational Self, Alfred Hornung

SOROUD: The journal of Literacy Criticism

Poetry and narration are among the most distinctive expressions of lifewriting. Poetic and narrative representations of the self, often associated with discrimination and disease, have got a psychotherapeutic effect. Ideally, collaborating agents in life- writing and narrative would produce a kind of societal knowledge with a global dimension, transcending the individual selfawareness, creating thus a framework for a would-be social integration. This paper is concerned with Audre Lorde’s poetic and narrative report on breast cancer, preceding her years in Berlin as a visiting professor in the 1980s, when her own experience as a “black lesbian poet or feminist lover” testified …

The Hunting Charge, Omar Mounir

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

Written in the form of a deliberately polemical essay, this text challenges the very concept of the 'hunting permit' and proposes to replace it with that of the 'hunting charge', effecting a conceptual revolution with profound legal implications regarding the status of game and the rights and duties of hunters. The author denounces the dominant mentality of hunters who, armed with their paid permit, believe themselves authorised to harvest without limits or responsibilities, ignoring the biological cycles of game, the issues of species balance, and the fragility of the environment, and assimilating hunting to a simple 'purchased right' rather than …

On The Use Of Lorawan For Smart Fishing Applications In The Blue Economy Sector, Eva Shayo

Tanzania Journal of Engineering and Technology (TJET)

The growth of digital technology is expected to transform small-scale fishery sectors, where a need for robust, low-cost, long-range communication networks becomes critical. There exist several technologies that are used in the fishery sector but they are never affordable to small scale fisheries. This study evaluates the feasibility of using low cost Long Range Wide Area Network (LoRaWAN) technology specifically tailored for smart fishing environments to small scale fishery sector. Using simulation, we assess the performance of the key performance metrics including probability of success and energy efficiency under varying device densities and time. During evaluation, we considered end devices …

Physicochemical Properties And Chemical Compositions Of Cashew Nut Shell Liquid Extracted With Carbon Dioxide–Expanded Hexane, Neema Msuya, Joseph Yn Philip, Frank Jacob, Kando K. Janga

Tanzania Journal of Engineering and Technology (TJET)

Cashew nut shell liquid (CNSL) is a mixture of phenolic compounds that can effectively replace commercially available phenols in various applications. This study investigated the physicochemical properties and chemical composition of CNSL extracted using CO₂–expanded hexane (CXH) and compared to the traditional Soxhlet extraction method. Steamed cashew nut shells (sCNS) were used in both cases.  The CXH was carried under varying CO₂-mole fractions (0.468-0.892) and temperatures (20-36 °C) whereas Soxhlet extraction was performed at atmospheric pressure and hexane boiling point. Response Surface Methodology (RSM) with Central Composite Face-Centred Design (CCFD) was employed to evaluate the effect …

Enhancing Community Engagement Through ‘Nitunze Kilombero’ Mobile App: Case Of Climate Land Use And Cover Management For Kilombero Basin, Ghanima Chanzi, Subira Munishi

Tanzania Journal of Engineering and Technology (TJET)

The Kilombero Basin in southeastern Tanzania faces significant challenges due to rapid land use and land cover (LULC) changes driven by climate change, population growth, and unsustainable farming practices. This study assessed the role of community engagement and digital reporting through the 'NITUNZE KILOMBERO', mobile application in supporting water resources management in the basin. The App facilitates real-time reporting of environmental issues, provides educational resources, and enables collaboration between local communities and authorities. A mixed-methods approach, including household surveys and key informant interviews, was employed to assess the app's effectiveness. Results indicate high community awareness of LULC impacts, with 85% …

Translating Science Into Evidence-Based Policy For The Protection And Restoration Of Essential Fish Habitat, Olivier Le Pape, Benjamin J. Ciotti, Karen E. Van De Wolfshaar, Rochelle D. Seitz, Julia Friese, David Eggleston, Elliot J. Brown, Rachel M. Turnbull, Filipe Martinho, Adam Waugh, Francisco E. Werner, Kenneth A. Rose

School of Biological and Marine Sciences

Coastal and estuarine ecosystems are vital as essential fish habitat (EFH). Given accelerating climate- and human-driven environmental change, conserving these habitats is increasingly urgent to ensure the sustainability of marine populations and their associated fisheries. This paper examines how scientific knowledge is being used to support management of EFH in the USA, Europe, and elsewhere. We find that while scientific knowledge to identify and quantify important habitats has rapidly increased, the transfer of this knowledge to management practice has been limited and slow, resulting in important habitats being vulnerable to degradation. Through an international review of EFH concepts and their …

Why Not Pachucos? Mexican Americans, Hollywood, And The Impact Of Sleepy Lagoon In The 1940s And 1950s, Krystal Catalina Ledesma

Journal of 20th Century Media History

The unsolved murder of a young Mexican American on the outskirts of Los Angeles in 1942—commonly known as the Sleepy Lagoon Murder—came at a pivotal time in Mexican American history. The consequent arrests, unjust trial, and imprisonment of over one dozen young Mexican American men caused such a stir that Sleepy Lagoon is considered a precursor to the infamous Zoot Suit Riots of 1943. During the Sleepy Lagoon trial, impassioned leftists in Los Angeles created the Sleepy Lagoon Defense Committee (SLDC) to raise awareness about the crime and trial and to collect funds from supporters across the U.S., who ranged …

J3) The Autopoiesis Of Pilgrimage Tourism: How Cruise Passengers Self-Organise Transformational Meaning In Mass Tourism, Taja Macek, Tadeja Jere Jakulin

International Religious Tourism and Pilgrimage Conferences

Modern cruise tourism presents a theoretical paradox for the Mediterranean basin. Every year, millions of passengers sail along maritime routes that follow ancient pilgrimage routes. They head towards Rome, the Holy Land, and the coastal approaches to Lourdes, Santiago, and Montserrat. All this takes place within one of the most operationally regulated and commercially standardised forms of mass tourism. Even within this structural rigidity, travellers regularly report profound personal transformation, spiritual encounters, and meaning-making that are strikingly reminiscent of traditional pilgrimage narratives (Collins-Kreiner, 2010; Olsen & Timothy, 2006). This discrepancy between the system's design and the individual's experience poses a …

The Shorthorn: July 18, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: July 25, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthon: July 3, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: June 20, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: May 2, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: April 19, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: April 18, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: April 17, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.

The Shorthorn: April 13, 1984

The Shorthorn Newspaper Collection: 1980s

No abstract provided.