Digital Commons Network^™

A Phase Ii Trial Of Defactinib Combined With Avutometinib In Patients With Metastatic Uveal Melanoma, Rino S. Seedor, Mizue Terai, Sergei A. Koshkin, Andrew E. Aplin, Marlana Orloff, Erin Sharpe-Mills, Madeleine Naccarato, Aurora Mills, Alfredo A. Molinolo, J. Silvio Gutkind, Takami Sato

Kimmel Cancer Center Faculty Papers

Background: Treatment options are limited, and outcomes remain poor for patients with metastatic uveal melanoma (MUM). We conducted an investigator-initiated, prospective, single-arm, single-institution, phase II study evaluating the combination of an FAK inhibitor (defactinib) with a RAF/MEK inhibitor (avutometinib) for the treatment of MUM. Methods: From February 2021 through January 2023, 12 patients with MUM were treated with the combination of defactinib and avutometinib. Defactinib was given 200 mg twice daily, and avutometinib was given 3.2 mg twice a week. Both drugs were given for 3 weeks on and 1 week off (28-day cycle). Disease control rate was the primary …

Ecological Footprint Assessment, Santina Benincasa

Open Educational Resources

This handout guides students through a structured ecological footprint assessment using the online Footprint Calculator. By following a series of steps—selecting their location, entering detailed lifestyle information, and reviewing personalized results—students evaluate how many planets would be required if everyone lived with their same resource consumption patterns. The activity prompts learners to identify the largest contributors to their footprint, quantify their impact in global hectares, and explore scenario-based changes that could reduce their environmental demand. Through reflection, students consider how everyday human behaviors influence Earth’s productive capacity and resource availability. Overall, the exercise encourages critical thinking about sustainability and personal …

Correlating High-Resolution Terrestrial Organic Carbon Isotope Records Across The Cretaceous-Paleogene Boundary, Gregory D. Price, Rhodri M. Jerrett, Lauren K. O'Connor, Emily Dearing Crampton-Flood, Bart E. Van Dongen, Sabine K. Lengger, Marc Davies

School of Geography, Earth and Environmental Sciences

The Cretaceous–Paleogene boundary (∼66 million years ago) represents the most recent mass extinction event when an estimated 75% of all species became extinct, including all non-avian dinosaurs. Here we focus on the stable carbon isotope (δ¹³C) analysis of coal and coaly sediments across the terrestrial K/Pg boundary from 10 sites, between 42 and 64°N, USA and Canada. Our δ¹³C data set shows a statistically significant positive correlation with paleolatitude that we interpret as a consequence of our lower latitude sites being relatively warmer and more humid than our higher latitude sites. Temporally, our data indicates that …

An Ecophysiological Approach To Improving Health Outcomes Of Ornamental Shrimp During Aquarium Trade And Transportation, Sancha Conway Holroyd, John Spicer, Robert P. Ellis, Lucy Turner

School of Biological and Marine Sciences

Ecophysiology examines the interactions between an organism’s physiology and its environment. It seeks to understand how an organism functions and adapts under changing conditions. This has direct applications to live-trade aquaculture sectors, including the ornamental aquarium trade, where traded animals experience a variety of changing, and often stressful, environmental conditions that can threaten their health and survival. This review proposes a role for ecophysiology in managing organismal health, using Hatch (1962) theoretical framework of disease and dysfunction as a foundation for defining and distinguishing health. We focus on tropical (marine and freshwater) ornamental shrimp as an exemplar group to highlight …

Health Profile Of Brazilian Mothers, Carlos Eduardo Siqueira

Gastón Institute Publications

No abstract provided.

Impact Of Social Media-Driven Feeding Practices On The Gut Microbiome Of Captive Asian Elephants (Elephas Maximus) In Surin, Thailand, Pongpreecha Malaluang, Nuttapon Bangkaew, Jaruwan Chaiyakhot, Patinya Patikae, Nattaya Watwiengkam, Phimphanit Choklikitumnuey, Thanaphat Phupanna, Sudachanok Phowiset, Prim Chuesaard, Tarid Purisotayo

The Thai Journal of Veterinary Medicine

This study investigated the effects of social media-driven live-streaming dietary supplementation on the gastrointestinal microbial community of captive Asian elephants (Elephas maximus) at the Elephant Kingdom, Surin Province, Thailand. A hierarchical two-tier observational design was used: Tier 1 compared a minimal-supplementation control group (Group H, n = 6) with a frequent heterogeneous-supplementation group (Group L, n = 18); Tier 2 compared, within Group L, low-frequency (Group A, ≤ 3 sessions per week, n = 7) and high-frequency (Group B, > 3 sessions per week, n = 11) live-streaming sub-groups. Faecal microbial profiles were obtained by 16S rRNA gene (V3–V4) …

Technical Disclosure: Integrated Space Readiness Training Center (Isrtc), Christopher L. Eckes

Defensive Publications Series

Current ground-based deep-space environmental analogs suffer from an institutional vulnerability designated as "Escape Room Bias." When human subjects operate under an implicit institutional guarantee of safety, their cognitive, behavioral, and adaptive responses default to gamified problem-solving rather than genuine expeditionary survival. This psychological insulation limits the validity of collected behavioral datasets to less than 20% of actual deep-space operational reality, leaving aerospace organizations blind to the most critical human failure mode in high-consequence environments: the psychological freeze response under unyielding peril.

The Integrated Space Readiness Training Complex (ISRTC) eliminates this predictive gap by establishing an enduring Dynamic Test Assembly operating …

Design, Fabrication, And Performance Evaluation Of A Recycling Machine For Converting Biodegradable Waste Into Compost, Mohamed T. Eraky, M.M Radwan, Abdelkhalik Eladl

Mansoura Engineering Journal

This study evaluates the technical feasibility of composting shredded printed paper blended with organic waste using a manually operated aerobic composting system. The investigation focused on process performance under controlled initial conditions, particularly an optimized carbon-to-nitrogen (C:N) ratio of 30:1. Three composting piles were constructed with systematic variations in moisture content, aeration frequency, and additive composition (poultry manure, yeast, crushed eggshells, and cardboard) to assess their influence on thermal behavior and decomposition efficiency. Process performance was monitored through continuous temperature profiling and periodic observation of physical parameters, including color development and material degradation rate. Among the experimental setups, Pile 3 …

Electrospun Nanofiber Dressings: Advances In Fabrication, Polymers, And Clinical Applications For Skin Healing, Ahmed Yaseen, Maher Abdulrazzaq Luqman Al-Hakeem, Yasir Qasim Almajidi, Yaseen Taha Aljuburi

Maaen Journal for Medical Sciences

The increasing global need for more effective wound care arises because conventional dressings have limited antibacterial efficacy and other shortcomings. The protection that is provided by the materials used for dressing and the drug delivery to the wounds is crucial in the management of wounds. Today, extracellular matrix ECM structure and function-mimicking electrospun nanofiber membranes are deemed one prospective next-generation alternative for dressings in wounds. This review examines electrospun nanofiber dressings with an overview of fabrication principles, polymer selection, and challenges for clinical translation in an attempt to establish the current status and prospects of these dressings in the management …

The Host's Immune Responses Against Viruses: How We Know Our Own Bodies And How Our Bodies Defend Themselves From Viruses, Eman A. Muhsin, Neyaf Majid Alageedi, Shahrazad Ahmed Khalaf

Maaen Journal for Medical Sciences

Background: Viral infections pose a significant threat to health worldwide, requiring a coordinated and effective immune response to limit and eventually eliminate viral infection. The purpose of this review is to examine the different ways by which the immune system responds, both by innate and adaptive pathways, against viral infections, along with the mechanisms by which viruses evade host immune responses.

Method: A systematic literature review was performed with an organized search through the following databases; PubMed, Scopus, Web of Science and ScienceDirect. The search was for studies published between 2015-2025. The final number of included articles was 45 as …

Antibacterial Efficacy Of Resin-Based Dental Composites Modified With Antibacterial Agents Against S. Mutans: A Systematic Review, Ahmad Setiawan Jarigau, Erwin Gunawan, Muhammad Akira Takashi Dharma, Fanny Dinda Nur Aulia, Lenni Indriani Hatta, Nurhayati Natsir

International Arab Journal of Dentistry

Introduction: Dental caries caused by Streptococcus mutans is a leading cause of dental restoration failure. Enhancing composite resins with antibacterial agents aims to inhibit bacterial growth and prolong restoration life.

Objectives: This review evaluates the anti-bacterial agents efficacy of these modified composites against S. mutans and explores their mechanisms and potential clinical benefits.

Methods: A comprehensive literature search was conducted across multiple databases following PRISMA guidelines, focusing on in vitro studies published between 2015 and 2025. Studies evaluating composites with antibacterial additives against S. mutans using standard microbiological assays were included. The quality of eligible studies was assessed using the …

Comparison Of Three Intraoral Scanners For Digital Impressions Of Biologically Oriented Preparation: An In-Vivo Study, Lara Habli, Pascale Habre-Hallage, Hani Tohme, Dany Noujaim, Maryse Nassif, Camille Haddad

International Arab Journal of Dentistry

Introduction: The accuracy of intraoral scanners (IOSs) in capturing a Biologically Oriented Preparation Technique (BOPT) remains uncertain. The aim of this study was to evaluate the accuracy of digital impressions obtained with three intraoral scanners for recording BOPT preparations.

Methods: A maxillary central incisor was prepared following BOPT. After temporization, a conventional polyvinyl siloxane impression was scanned with a desktop scanner to obtain a reference model. Forty-two scans (n D 14 per scanner) were recorded with three IOSs—Trios 3, Sirios, and Helios 680—by a single operator under standardized conditions. Accuracy was assessed using Geomagic Control X by calculating 3D surface …

Evaluation Of Optimal Force For Intrusion Of A Periodontally Compromised Maxillary Anterior Dentition Treated With Fixed Orthodontics – A Finite Element Analysis, Tanzim Ahmed, Amrita Puri, Aatira Nair, Anshul Singla, Mathew Koshy Vaidyan, Shruti Sharma, Chhavi Singh

International Arab Journal of Dentistry

Introduction: Adult orthodontic treatment is increasingly sought due to aesthetic and functional concerns, often involving periodontally compromised patients with altered biomechanics. Reduced bone support shifts the center of resistance and necessitates lower, carefully controlled forces, while finite element modeling has become a key tool to analyze tissue response under such conditions.

Objectives: The study aimed to determine the optimal intrusive force for periodontally compromised maxillary anterior teeth using Finite Element Analysis (FEA).

Methods: A 3D finite element model of the maxillary anterior dentition was created and divided into healthy and compromised halves, the latter with one-third alveolar bone loss. A …

Impact Of Antihypertensive Medications On Implant Success: A Retrospective Cohort Study On Monomedicated Patients, Antony Chidiac, Stephanie Mrad, Charbel Kachouh, Richard M. Sadaka, Joseph Bassil

International Arab Journal of Dentistry

Objective: The aim of this study main is to analyze the influence of antihypertensive treatments on the failure and survival rates of dental implants.

Methods: Medical records of 586 patients who received a total of 1,814 dental implants between 2012 and 2022 met the inclusion criteria and were retrospectively reviewed. Patients were divided into two groups: a control group comprising 512 systemically healthy patients with 1581 implants, and a group of 74 patients taking only antihypertensive medications who received a total of 233 implants. Implant failure was assessed according to criteria defined by the International Congress of Oral Implantologists.

Results: …

Hypo-Responsiveness Of The Dental Pulp In Patients With Type 2 Diabetes And Hypertension: A Cross-Sectional Study, Kavitha M, Mallolu Anthony Sanjana Vijay, Niveditha B, Fathima A.I, Pavithra D, Vigneshwaran J

International Arab Journal of Dentistry

Introduction: Diabetes mellitus and hypertension, two of the most prevalent metabolic disorders worldwide, exert profound and progressive effects on multiple physiological systems. While their systemic complications are well documented, their subtle yet clinically significant impact on oral structures, particularly the dental pulp, remains underexplored.

Objectives: This study aims to assess the functional responsiveness of dental pulp nerves in individuals with type 2 diabetes mellitus and systemic hypertension, and to compare the findings with responses from healthy individuals, using an Electric pulp tester (EPT) as a diagnostic tool.

Methods: A total of 600 teeth from 75 adult patients (25 diabetic, 25 …

Minimally Invasive Decompression And Long-Term Follow-Up Of An Orthokeratinized Odontogenic Cyst Of The Mandible: A 7-Year Case Report, Akram Belmehdi, Karima El Harti

International Arab Journal of Dentistry

Introduction: Orthokeratinized odontogenic cyst (OOC) is a rare developmental jaw lesion with indolent behavior and low recurrence potential.

Case presentation: A 33-year-old healthy male was referred after incidental discovery of a mandibular radiolucency. Cone-beam CT revealed a well-defined unilocular lesion in close relation to the inferior alveolar canal. Aspiration confirmed its cystic nature, and a conservative decompression was performed using a rubber drain to reduce lesion size and preserve adjacent structures. Histopathologic examination identified orthokeratinized epithelium consistent with OOC. After seven months of decompression, the lesion showed marked ossification, allowing safe enucleation and peripheral curettage. Radiographic follow-ups at 19 months …

Analisis Respon Siswa Berdasarkan Asesmen Berbasis Taksonomi Solo (Structure Of The Observed Learning Outcome) Pada Materi Perubahan Fisika Dan Kimia, Nurul Amaliyah, Imraatul Mufidah, Dyne Rizki Puspitasari, Siti Zubaidah

Journal of Innovation and Teacher Professionalism

This study aimed to describe the level of seventh-grade students' understanding of physical and chemical changes through the analysis of their responses using a SOLO taxonomy-based assessment. The study employed a qualitative descriptive approach, with lesson implementation conducted through the Lesson Study stages of plan, do, and see. The participants were 31 seventh-grade students of SMP Laboratorium Universitas Negeri Malang. Data were collected from students' written responses to four essay questions representing the unistructural, multistructural, relational, and extended abstract levels of the SOLO taxonomy and were analyzed descriptively. The results showed that most students were at the …

Influence Of Genetic Relationships On The Spatial Distribution Of Breeding Eastern Wild Turkeys (Meleagris Gallopavo Silvestris) In West-Central Louisiana, Rachel D. Price

LSU Master's Theses

Eastern wild turkeys (Meleagris gallopavo silvestris) have a complex social system influenced by dominance hierarchies and exhibit seasonal variation in gregarious behaviors. Previous work has examined the influence of kin relationships on interactions between same sex conspecifics and flock associations, but information on how genetic relatedness influences interactions between individuals remains lacking. We constructed a dyad-based social network using high-resolution GPS data from 179 female and 68 male wild turkeys in west-central Louisiana during the 28-day period before a females’ 1^st nest initiation to quantify interaction probability based on genetic relatedness and age. Our findings suggest that …

Paediatrics & Child Health | Newsletter Vol 8 Issue 1, Department Of Paediatrics & Child Health

Department of Paediatrics & Child Health Archives

• I write to you in unsettled times...
• Service | Clinics and Nursing
• World Autism Awareness Day 2025 — Understanding Autism: Myths, Challenges & Strategies
• Research | Conferences, Field Sites, Studies and Dissemination Strategies
• MoU with SHINE
• Three honours at the 23rd Annual
• Protecting infant gut health in early life
• Academics | PG, UG, CME
• The Science Behind a Paediatrician’s Quick Diagnosis
• Making Immunology Simple for Clinical Practice
• Achievements
• Behind the Systems That Build Great Doctors
• 15,000+ physical therapists. 1,440+ posters. One team from Pakistan.
• Awards and recognitions
• After hours
• Ramzan Iftar Dinner
• Alumni reunion
• PRISMA appreciation night
• In the media …

Science, Uncertainty, And Stewardship: Climate Change Viewpoints In Higher Education, Jamie Jensen, Isaiah Aduse-Poku

ScholarsArchive Data

This dataset supports a Q-methodology study of climate change viewpoints among undergraduate students at Brigham Young University. Participants were recruited from an introductory non-majors biology course during Fall 2025. The study examined how students organized climate-change views across scientific evidence, human causation, uncertainty, political beliefs, religious stewardship, moral responsibility, perceived agency, climate policy, and future risks.

Comparative Evaluation Of A-Prf+ Or Collagen Membrane On Hard And Soft Tissue Changes Following Immediate Implant Placement: A Randomized Clinical Trial, Raagul S, Rahul Chopra, Sumit Malhotra, Prashansa Sharma, Ankur Tyagi, Nancy Singh

International Arab Journal of Dentistry

Objectives: To evaluate and compare clinical and radiographic parameters viz. Gingival Index (GI), Plaque Index (PI), Width of Keratinized Tissue (WKT), Midbuccal & Midlingual/Midpalatal soft tissue thickness (STT), ISQ values and crestal bone levels (CBL) using CBCT at baseline and 6 months in Group I (Immediate implant placement & A-PRF+) and Group II (Immediate implant placement & Collagen Membrane).

Methods: A total of 20 sites indicated for extraction were selected and randomly divided into: GROUP I : 10 sites were treated with immediate implant placement and covered with an A-PRF+ membrane and GROUP II : 10 sites were treated with …

Predictive Analysis For Success And Complications In Dental Implant Therapy Using Artificial Intelligence Models, Vishnu Priya Veeraraghavan, Aysha Jebin A, Isha Dusane, Govind Baheti, Ankita Agarwal, Santosh R Patil

International Arab Journal of Dentistry

Introduction: Dental implant therapy is a predictable treatment for tooth replacement, but its success is influenced by multiple patient, surgical, and systemic factors. Traditional statistical models, such as logistic regression, are limited in capturing nonlinear relationships among these variables. Artificial intelligence (AI) can integrate diverse predictors to enhance clinical risk assessment and improve treatment outcomes.

Objective: To identify key predictors of dental implant success and develop AI-based models capable of accurately forecasting implant outcomes using clinical and surgical parameters.

Methods: This retrospective cohort study analyzed data from 172 patients (219 implants) placed between 2020 and 2021. Patient demographics, systemic health …

Specific Carbohydrate Diet Versus Mediterranean Diet In Adult Patients With Mild To Moderate Ulcerative Colitis: A Randomized Controlled-Feeding Trial, Albert Sheng-Yin Chen, Long Nguyen, Brianna Gray, Katherine Williams, Jenny Gurung, Lauren Canha, Jessica Mcgoldrick, Jane Hubbard, Hamed Khalili

Student Papers, Posters & Projects

Background and aims: This pilot randomized controlled-feeding trial compared the effect of Specific Carbohydrate Diet (SCD) and Mediterranean diet (MeD) in mild to moderate ulcerative colitis (UC).

Methods: Seventeen adults were randomized to a 6-week SCD (n = 8) or MeD (n = 9) intervention. Primary outcome was change in partial Mayo Clinic score (pMCS).

Results: The study was discontinued early due to significant dropout (n = 9, 52.9%). There was no significant between-group differences observed for pMCS change (SCD, -0.8; MeD, -1.3; p = 0.499) or secondary outcomes. Exploratory metagenomic analysis revealed enrichment of Parasutterella excrementihominis …

Progesterone And Cerclage Together For Short Cervix: Evaluating Potential Complementary Effects For Improved Preterm Birth Prevention, Vincenzo Berghella, Ilaria Paladino, Moti Gulersen, Lauren Sayres, Amanda Roman, Rupsa C. Boelig

Department of Obstetrics and Gynecology Faculty Papers

Management of patients with a short cervical length (CL) on transvaginal ultrasound (TVU) often involves therapy with vaginal progesterone and/or cervical cerclage. Although these interventions are frequently viewed as alternative strategies, they may also represent complementary approaches targeting different mechanisms involved in spontaneous preterm birth. As in other areas of medicine, therapies with different mechanisms are often used together rather than as mutually exclusive options. In line with current level 1 evidence from randomized controlled trials (RCTs) and meta-analyses of RCTs on either vaginal progesterone or cerclage, in singleton gestations with no prior spontaneous preterm birth (SPTB), vaginal progesterone is …

Technical Disclosure: The Unified Metric-Shift Engine (Umse), Christopher L. Eckes

Defensive Publications Series

This technical disclosure formalizes the system engineering specifications for the Unified Metric-Shift Engine (UMSE). Rather than treating elemental replication, spatial teleportation, and temporal navigation as independent physical anomalies, the UMSE architectural framework unifies them into a single hardware-software stack built upon 2D viscoelastic substrate mechanics .

By manipulating the z-axis coordinate projection and helical phase vectors of localized soliton excitations (particles), the system operates entirely within room-temperature, non-equilibrium phase space . Inspired by the Nobel-Prize-adjacent mechanics of Soliton Trapping (Caltech) and Laser Wakefield Acceleration (LWFA), this disclosure details how a garage-budget harmonic computer can manipulate the fundamental universal source code—the …

Female Resistance To Patriarchal Norms: A Study Of Identity And Self-Determination In The Film Enola Holmes (2020), Mikkial Muna, Eli Nofriati, Zuraini Zuraini

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study examines the representation of women's resistance to patriarchy through identity formation and self-determination in the film Enola Holmes (2020). Set in the Victorian era, the film portrays a patriarchal society that limits women's rights, educational opportunities, and freedom to determine their own lives. This study employed a descriptive qualitative design with a grounded theory approach. The primary data were collected through repeated observation of the film, focusing on relevant scenes, dialogues, character actions, and visual elements, and were analyzed using thematic analysis interpreted through the perspectives of patriarchy and liberal feminism. The findings reveal that patriarchy is represented …

Understanding The Effects Of Simulated Microgravity On Staphylococcus Epidermidis And Escherichia Coli In Co-Culture, Emma Costa, Mitchell K. Villafania, Makaila Olson, Kareigh N. Gammon, Hugo Castillo

Beyond: Undergraduate Research Journal

With the popularity of space travel increasing, it is important to understand the effects of microgravity on microbial communities as alterations on bacterial interactions can occur. Staphylococcus epidermidis and Escherichia coli are bacteria that are commonly found within human microbiomes. S. epidermidis is a cocci-shaped gram-positive bacterium that is part of the human skin microbiome. However, it can gather on sites of open skin and enter the body leading to an infection. E. coli is a rod-shaped gram-negative bacterium that can be found in the human gut microbiome. The pathogenic strains of E. coli have the potential to cause harmful …

New Products, New Ideas, Paula Lauer

CompassPoint

No abstract provided.

Beyond Treatment- The Value Of Prognosis Discussions In Dentistry, Shwetha Rodrigues Dds

Virginia Dental Journal

No abstract provided.

Prepared Or Not? Perceptions Of Novice Counseling Professionals On Working With Trauma Clients, Christina L. Richardson

Walden Dissertations and Doctoral Studies

The prevalence of trauma across clinical settings and limited trauma training for clinicians can negatively affect trauma survivors. The impact of novice clinicians’ lack of preparedness and its implications for clients should be important considerations for educators, supervisors, and policymakers. The purpose of this qualitative study was to explore the lived experiences of novice counselors and their preparedness to work with trauma survivors. Grounded in descriptive phenomenology, this study explored participants’ perceived preparedness to work with trauma survivors and the ways these experiences may inform counselor education and supervision. Participants were provisionally licensed counselors within three years of graduating from …