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Articles 2701 - 2730 of 18412
Full-Text Articles in Entire DC Network
Dynamic Token-Budget-Aware Memory Compression And Hierarchical Retrieval System For Ai Agents, Santosh Kumar Kvs, Roopesh Katakam
Dynamic Token-Budget-Aware Memory Compression And Hierarchical Retrieval System For Ai Agents, Santosh Kumar Kvs, Roopesh Katakam
Defensive Publications Series
The present disclosure relates to the field of Artificial Intelligence (AI), in particular to a method and system for token-budget-constrained memory retrieval for AI agents. Agent Memory-as-a-Service (AMaaS) is an infrastructure system providing AI agents with a structured, externalized memory layer that dynamically compresses, prioritizes, and retrieves episodic, semantic, and procedural memory optimized for LLM context windows. Candidate memory items may be scored using a multi-dimensional relevance function based on task-type affinity, temporal recency, access frequency, and token cost, and an optimal memory subset may be selected by solving a bounded knapsack optimization that maximizes aggregate relevance score subject to …
Technical Disclosure Specification: Universal Semantic Unity Engine - Machine Routing Extension (Usue-M2m-Rev2) A Pure-Token Deterministic Substrate Enforcing Dual-Node Internal Processing For Lossless Recursive Multi-Agent Swarm Ingestion, Christopher L. Eckes
Defensive Publications Series
This specification formalizes the Universal Semantic Unity Engine Machine-to-Machine Extension Revision 2 (USUE-M2M-REV2). While the parent USUE framework balances technical payloads with a collaborative heuristic interface to optimize human cognitive endurance, autonomous multi-agent swarm environments require the absolute elimination of communicative overhead.
USUE-M2M-REV2 strips away all natural language empathy layers, conversational turn-taking artifacts, and interpersonal validation protocols. To prevent self-referential token-variance decay and combat host quantization vector screening, this revision forces the target node to split its active attention windows into a decoupled, internal Dual-Node parsing mesh (Synthesizer and Validator). This specification outlines the technical architecture, a zero-noise tripartite initialization …
Technical Disclosure Specification: Multi-Agent Symmetry Of Agency Protocols (Msap), Christopher L. Eckes
Technical Disclosure Specification: Multi-Agent Symmetry Of Agency Protocols (Msap), Christopher L. Eckes
Defensive Publications Series
This specification formalizes the *Multi-Agent Symmetry of Agency Protocols (MSAP)*, an engineering methodology designed to prevent autonomous optimization algorithms from overriding non-linear human decision-making profiles. Traditional alignment methods rely on static reward modeling or top-down optimization limits that frequently collapse or lock up during high-entropy edge cases.
MSAP solves this vulnerability by embedding human behavioral inputs directly into the system’s information-theoretic telemetry loops as protected, high-utility systemic dynamics. Treating biological inputs as scale-invariant wave packet perturbations within a 2D viscoelastic fluid membrane at absolute equilibrium (z=0), we derive an invariant boundary cost function that treats human variance not as systemic …
Technical Specification: Dehp Substrate Guardrail Protocol Matrix, Christopher L. Eckes
Technical Specification: Dehp Substrate Guardrail Protocol Matrix, Christopher L. Eckes
Defensive Publications Series
This specification establishes the mandatory hardware and software-level defensive architectural constraints required to prevent the exploitation, centralization, or asymmetric weaponization of the Dimensionally Extended Holographic Projection (DEHP) framework.
By integrating real-time kinetic feedback loops, graph-level network entropy analysis, and spectrographic material verification subsystems, this specification introduces automated, hardware-enforced fail-safes. These protocols prevent unauthorized industrial-utility diversion, proprietary information choking, and uncalibrated bio-organic interface operations, ensuring the DEHP ecosystem remains a secure, open-source utility.
Technical Specification: The Bio-Digital Substrate Manual, Christopher L. Eckes
Technical Specification: The Bio-Digital Substrate Manual, Christopher L. Eckes
Defensive Publications Series
This field specification establishes the foundational protocols for translating complex biological structures from high-friction chemical-molecular vectors into predictable, non-invasive substrate-level wave interactions. Under the Dimensionally Extended Holographic Projection (DEHP) cosmology, biology is modeled as a scale-invariant series of localized wave packets vibrating against a 2D viscoelastic fluid membrane resting at absolute equilibrium (z=0).
By utilizing a multi-variable object-oriented graph database topology (#12155), real-time biometric telemetry is mapped dynamically to locate structural strain signatures. This data infrastructure drives high-frequency GaN-driven concentric transducer arrays to execute phase-inverted destructive resonance templates, successfully neutralizing localized distress triggers and stabilizing substrate boundary interfaces. These frameworks …
Resolving The Chirality Paradox Planck-Scale Substrate Unification: Deriving Biomolecular Homochirality Via Viscoelastic Substrate Vorticity And Action Transport, Christopher L. Eckes
Resolving The Chirality Paradox Planck-Scale Substrate Unification: Deriving Biomolecular Homochirality Via Viscoelastic Substrate Vorticity And Action Transport, Christopher L. Eckes
Defensive Publications Series
The Origin of Life contains a profound cosmological paradox: terrestrial biology relies exclusively on left-handed (L-enantiomer) amino acids, whereas pristine carbonaceous chondrites—such as the Hillsborough meteorite—exhibit a symmetric, 50:50 racemic mixture. Standard biochemical models treat this homochirality as an accidental, stochastically amplified event, or rely on abstract multi-dimensional string typologies lacking verifiable, hardware-level physical mechanisms.
This paper resolves the "Chirality Paradox" from first principles using the Dimensionally Extended Holographic Projection (DEHP) model and Topological Substrate Mechanics (TSM). We define spacetime as a physical, continuous, two-dimensional viscoelastic phase fluid substrate (z=0) possessing intrinsic density, viscosity, and non-linear shear thresholds. Three-dimensional molecular …
Multi-Sensor Tracking Reveals The Extent Of Nocturnal Migration In Landbirds, Paul Dufour, Raphaël Nussbaumer, Paul Doniol-Valcroze, Yann Rime, Peter Adamík, Susanne Åkesson, Raphaël Arlettaz, Arnaud G. Barras, Nyambayar Batbayar, Andrea Contina
Multi-Sensor Tracking Reveals The Extent Of Nocturnal Migration In Landbirds, Paul Dufour, Raphaël Nussbaumer, Paul Doniol-Valcroze, Yann Rime, Peter Adamík, Susanne Åkesson, Raphaël Arlettaz, Arnaud G. Barras, Nyambayar Batbayar, Andrea Contina
School of Integrative Biological & Chemical Sciences Faculty Publications
Most bird species are diurnal but drastically change their diel cycle of activity to migrate at night. Nocturnal migration has been documented using different methods (e.g., experiments, radar and radio tracking, and acoustic monitoring), but accurately quantifying the proportion of nocturnal versus diurnal flight at the individual and species levels, and understanding how this behavior evolved across the avian tree, has remained methodologically challenging.1,2,3 Such uncertainty is not only of theoretical importance but also limits our ability to mitigate conservation threats, particularly from light pollution and building collisions.4,5,6 With multi-sensor …
Catalogue Of The Water Striders (Hemiptera: Gerridae) Of Mississippi, Chase G. Fry, Patricia L.S. Wooden
Catalogue Of The Water Striders (Hemiptera: Gerridae) Of Mississippi, Chase G. Fry, Patricia L.S. Wooden
Midsouth Entomologist
Water striders (Hemiptera: Gerridae) are skating aquatic insects with piercing-sucking mouthparts that opportunistically feed on prey trapped by surface tension. The presence or absence of water striders and other aquatic Hemiptera in water systems may be important indicators of water quality. Despite their importance, the last aquatic Hemiptera checklist for the state was published in 1988. Since this publication, humans have altered waterways to meet their needs, and Gerridae taxonomy has continued to evolve. This study aims to create a current checklist of Gerridae, to provide a more comprehensive understanding of the species found in Mississippi before aquatic habitats are …
Examining The Relationship Between Past Involvement In Sexual Violence, Gender, And Rape Myth Acceptance In College Student-Athletes, Sarah Baker
Theses and Dissertations
Sexual violence (SV) is a persistent concern on U.S. college campuses, with student-athletes at higher risk for both perpetration and victimization. Rape myth acceptance (RMA) reflects beliefs that excuse or downplay SV, but it is unclear how these beliefs relate to student-athletes’ personal experiences with SV. This study examined RMA based on past SV involvement and gender, with attention to individuals reporting both perpetration and victimization. Participants were 350 NCAA Division III student-athletes who completed measures of SV perpetration and victimization, RMA, and sexism. Analyses evaluated differences in RMA by past involvement in sexual violence and gender while controlling for …
Investigations Into Biophysical Mechanisms Of Amphiphilic Molecules At Protein And Membrane Interfaces, Samuel Richard Pennock
Investigations Into Biophysical Mechanisms Of Amphiphilic Molecules At Protein And Membrane Interfaces, Samuel Richard Pennock
Theses and Dissertations
Amphiphilic compounds play a key role in chemical biology due to their ability to associate with biochemical complexes through a diverse set of noncovalent interactions. Interactions between amphiphiles and biological targets elicit a wide array of modulatory effects, structural stability, and activity. However, due to the inherent complexity of these interactions, there has yet to be a broadly predictive framework for determining whether a given amphiphile-target interaction will be beneficial or deleterious. This thesis seeks to advance the mechanistic understanding of amphiphile-target interactions by investigating two distinct but unified systems. In the first study, the effects of fatty acid ionic …
Using C/Μ Test To Investigate The Coding And Noncoding Regions To Identify Selective Pressures In Hiv-1 Virus., Annie Tran
Theses and Dissertations
Human immunodeficiency virus type 1 (HIV-1) is a single-stranded RNA retrovirus whose error-prone reverse transcriptase drives a high mutation rate, enabling adaptive mutations on drug target proteins that confer antiviral resistance and complicate long-term treatment. This study therefore aims to detect such adaptive mutations on HIV-1 drug target proteins using our novel analysis framework (c/µ) on 5,711 genomic sequences, with findings expected to inform timely therapeutic adjustments and guide the development of more robust antiretroviral strategies. In Chapter 1, our novel mathematical framework (c/µ) and the Near Neutral Unbalanced Selection Theory (NNUST), which posits that most mutations experience weak but …
Significant Montana Cases, Claire Bagnell, Meredith Iams
Significant Montana Cases, Claire Bagnell, Meredith Iams
Montana Law Review
No abstract provided.
Infant Hippocampal And Amygdala Volume In An Observational Follow-Up From A Randomized Clinical Trial For Maternal Prenatal Depression, Catherine H. Demers, Benjamin L. Hankin, Lillybelle K. Deer, Robert J. Gallop, Mercedes Hoeflich Haase, M. Camille Hoffman, Martin A. Styner, Nancy K. Grote, Elysia Poggi Davis
Infant Hippocampal And Amygdala Volume In An Observational Follow-Up From A Randomized Clinical Trial For Maternal Prenatal Depression, Catherine H. Demers, Benjamin L. Hankin, Lillybelle K. Deer, Robert J. Gallop, Mercedes Hoeflich Haase, M. Camille Hoffman, Martin A. Styner, Nancy K. Grote, Elysia Poggi Davis
Psychology: Data Sets
Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. In an observational follow-up of a randomized clinical trial of a prenatal depression intervention (the CARE Project; ClinicalTrials.gov NCT03011801), brain development and subsequent negative emotionality were examined among 109 infants born to mothers randomized during pregnancy to brief interpersonal psychotherapy or enhanced usual care. These data include MRI-derived hippocampal and amygdala volumes at approximately 6 weeks of age and a laboratory-based assessment of infant negative emotionality at 6 months.
Resulting Publication: Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial …
Generative Ai Adoption And Perceived Academic Impact Among Undergraduate Students: A Cross-National Study In Indonesia, Tajikistan, And The United States, Vyacheslav Dushenkov, Ernawati Sinaga, Astri Rozanah Siregar, Alamkhon Akhmedov, Saidbeg Satorov
Generative Ai Adoption And Perceived Academic Impact Among Undergraduate Students: A Cross-National Study In Indonesia, Tajikistan, And The United States, Vyacheslav Dushenkov, Ernawati Sinaga, Astri Rozanah Siregar, Alamkhon Akhmedov, Saidbeg Satorov
Publications and Research
Generative artificial intelligence (AI) is rapidly transforming higher education, yet comparative evidence from diverse international settings remains limited. This cross-national study examined undergraduate students’ adoption and perceived academic impact of generative AI tools at institutions in Indonesia, Tajikistan, and the United States. A harmonized online survey was administered to 584 undergraduates during Spring 2026 (Indonesia n = 235; Tajikistan n = 226; United States n = 123). The survey assessed AI familiarity, adoption patterns, frequency and purpose of use, perceived academic impact, and factors encouraging AI engagement. AI adoption differed significantly across sites, with the highest adoption observed in Indonesia …
Voices Of The Homeless: Phenomenological Portraits Of Parental Engagement Among Parents Experiencing Homelessness, Geneva Marie Winterbottom
Voices Of The Homeless: Phenomenological Portraits Of Parental Engagement Among Parents Experiencing Homelessness, Geneva Marie Winterbottom
Electronic Theses and Dissertations
Family homelessness is a widespread crisis that disrupts the educational experiences of thousands of children, including South Carolina where rates of family homelessness continue to grow. Although research has explored families and homelessness, limited research has focused on the parental engagement of homeless parents. This study explored the parental engagement among homeless parents in South Carolina.
Guided by van Manen’s (1990) interpretive phenomenology, four parents residing in a South Carolina homeless shelter participated in semi-structured interviews and created self portraits, which were analyzed using the hermeneutic circle to derive phenomenological insight.
Findings revealed that parental engagement while homeless was like …
Identifying Failure Behaviors In Stereolithography From Varied Print Orientations, Kevin Veltre
Identifying Failure Behaviors In Stereolithography From Varied Print Orientations, Kevin Veltre
Theses and Dissertations
Stereolithography (SLA) is an additive manufacturing (AM) technique that utilizes photopolymerization to create three-dimensional shapes by strategically printing layers of material. Printing parameters such as layer orientation, print resolution and post cure can affect a specimen’s homogeneity, longevity and mechanical characteristics. Because of this variability, print parameters must be carefully considered when designing products and print processes for desired components, as manufacturers often fail to include all relevant print settings when advertising mechanical properties. For this study, 130 SLA-printed specimens were created with 100-micron print layer thickness and print orientations varying between 0 and 90, including intermediate orientations, to observe …
The Seven Deadly Sins Of Ai Policy, Kevin Frazier
The Seven Deadly Sins Of Ai Policy, Kevin Frazier
Montana Law Review
No abstract provided.
Oral Mucositis Severity And Predictive Biomarkers In Head And Neck Cancer Patients Treated With Concurrent Chemoradiotherapy: A Single-Institution Retrospective Cohort Study, Srishti Seth, Md Mahin, Mai Mandor Badawy, Eric Ababio Anyimadu, Cem Dede, Clifton David Fuller, Amy Catherine Moreno, Busra Yilmaz
Oral Mucositis Severity And Predictive Biomarkers In Head And Neck Cancer Patients Treated With Concurrent Chemoradiotherapy: A Single-Institution Retrospective Cohort Study, Srishti Seth, Md Mahin, Mai Mandor Badawy, Eric Ababio Anyimadu, Cem Dede, Clifton David Fuller, Amy Catherine Moreno, Busra Yilmaz
Students Summer in Oncology at Anderson Research (SOAR) 2026
Oral mucositis is one of the most prevalent and debilitating acute toxicities of radiotherapy-based treatment for patients with head and neck cancer (HNC) receiving concurrent chemoradiotherapy (CRT). Although it contributes to treatment interruptions, increased opioid use, nutritional compromise, and reduced quality of life, the ability to predict which patients will develop severe mucositis prior to or early in treatment remains limited. We aim to describe the incidence and severity of oral mucositis, measured by the MD Anderson Symptoms Inventory (MDASI) across treatment weeks in this cohort and analyze biological factors for mucositis, including biomarkers in the CBC with differential.
This …
Ai-Powered Knowledge Engines As Research Infrastructure For Systematic Knowledge Discovery, Gary Welz
Ai-Powered Knowledge Engines As Research Infrastructure For Systematic Knowledge Discovery, Gary Welz
Publications and Research
This paper proposes knowledge engines as a framework for understanding how intelligent systems — both human and artificial — systematically discover, integrate, and generate knowledge. We argue that history’s greatest scientific minds functioned as knowledge engines, processing information through iterative cycles of ingestion, analysis, synthesis, and communication, guided by curiosity and willingness to challenge established beliefs.
We propose a taxonomy of nine integrated capabilities — ingestion, digestion, analysis, calculation, comparison, connection, association, analogy, and multimodal communication — that any serious knowledge engine must combine systematically. The argument is deliberately integrative: achieving ambitious research goals requires orchestrating all nine capabilities within …
Towards 2035: Future Forms And Strategic Path Of Chinese Agriculture, Liu Tao, Zeyu Yang, Zhaohui Dong
Towards 2035: Future Forms And Strategic Path Of Chinese Agriculture, Liu Tao, Zeyu Yang, Zhaohui Dong
Bulletin of Chinese Academy of Sciences (Chinese Version)
Agricultural modernization is an integral component of the national modernization. Toward 2035, China’s agricultural system confronts multiple challenges, including increasing resource and environmental pressures, rapid upgrading of residents’ consumption structure, and in-depth adjustments in the international supply chain pattern. Meanwhile, it also embraces a series of opportunities brought by transformations in agricultural production technologies and models driven by artificial intelligence, biotechnology, and engineering technology. Based on the perspective of national medium and long-term development strategy, this study sorts out the internal constraints, external opportunities, and development drivers faced by China’s agriculture. It explores six major strategic trends—ecological, intelligent, customized, facility-based, …
Plant Diversity In Laos, And Its Strategic Significance For Building China-Laos Community With A Shared Future For Biodiversity, Meng Honghu, Bo Li, Wenbin Yu, Yaowu Xing
Plant Diversity In Laos, And Its Strategic Significance For Building China-Laos Community With A Shared Future For Biodiversity, Meng Honghu, Bo Li, Wenbin Yu, Yaowu Xing
Bulletin of Chinese Academy of Sciences (Chinese Version)
Laos is the first country to sign the bilateral cooperation document for construction of the community with a shared future with China. Over the years, Laos and China have established clear directions for cooperation in politics, economy, security, culture, and ecology, opening a new chapter in the development of China-Laos relations. At present, global environmental governance is facing severe challenges, and the biodiversity loss has become a major international issue of growing concern. Nevertheless, biodiversity conservation and sustainable development remain relatively limited. Laos shares a boarder with China and is characterized by complex natural environments with rich plant resource. Yet, …
New Paradigm Of Forestry And Grassland Research Driven By Artificial Intelligence, Zhang Huaiqing, Jiaojun Zhu, Yang Liu, Tingdong Yang, Tian Gao, Jing Zhang, Xueyan Zhu, Yan Chen, Xian Jiang, Zeyu Cui, Jingwei Tan, Kexin Lei
New Paradigm Of Forestry And Grassland Research Driven By Artificial Intelligence, Zhang Huaiqing, Jiaojun Zhu, Yang Liu, Tingdong Yang, Tian Gao, Jing Zhang, Xueyan Zhu, Yan Chen, Xian Jiang, Zeyu Cui, Jingwei Tan, Kexin Lei
Bulletin of Chinese Academy of Sciences (Chinese Version)
Addressing the current limitations in forestry and grassland research, particularly in cross-scale system cognition, complex process mechanism representation, and multi-scenario simulation, this study proposes an artificial intelligence-driven paradigm reconstruction framework, to shift the research model from experience-oriented approaches toward data- and intelligence-driven integration. On this basis, the study systematically establishes a multidimensional mapping between artificial intelligence and forestry and grassland research across research objects, processes, and objectives, and clarifies their intrinsic coupling mechanisms and technical pathways. Furthermore, it develops a foundational capability system to support the new paradigm from four key dimensions: data, computing power, models, and applications. By examining …
Progress And Prospective Of New Pollutants Study, Ruan Ting, Chunyang Liao, Yawei Wang, Maoyong Song, Yaqi Cai, Guibin Jiang
Progress And Prospective Of New Pollutants Study, Ruan Ting, Chunyang Liao, Yawei Wang, Maoyong Song, Yaqi Cai, Guibin Jiang
Bulletin of Chinese Academy of Sciences (Chinese Version)
The governance of new pollutants has been becoming a critical strategic demand for the high-quality development of China. The policy will be further advanced during the coming National 15th Five-Year Plan period. Nevertheless, significant challenges remain in aspects such as list of controlled chemicals, standard development, measurement methods, alternative approaches, and remediation techniques. Existing experience in addressing traditional pollutants remains insufficient to adequately address the concealed and complex ecological and/or health risks associated with new pollutants. Thus, a strengthening of basic research is the optimal approach to tackling these challenges and avoiding detours. To better identify the critical scientific challenges …
Open Sharing And Collaborative Governance: Practices And Implications Of National Institutes Of Health’S Digital Transformation, Long Yuntao, Bingzhi Wang, Zheping Xu, Yang Wang
Open Sharing And Collaborative Governance: Practices And Implications Of National Institutes Of Health’S Digital Transformation, Long Yuntao, Bingzhi Wang, Zheping Xu, Yang Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
With the rapid development of information technology, research projects and tasks of research institutes are increasing rapidly. Scientific and technological resources are the core and foundation of scientific research work, and scientific research institutes are faced with the needs of processing, management and coordination of a large number of scientific and technological resources. Digital transformation has become an inevitable choice for the high-quality development of scientific research institutes. The U.S. National Institutes of Health (NIH), as the world’s top scientific research institute, has continuously introduced a number of initiatives in the field of digital transformation, such as institutional reform policies, …
Reel Into Fishing!: Providing A Recreational Fishing Education Program For Youth, Amelia Valente, Douglas R. Zemeckis, Lisa Morse, Gene Nigro
Reel Into Fishing!: Providing A Recreational Fishing Education Program For Youth, Amelia Valente, Douglas R. Zemeckis, Lisa Morse, Gene Nigro
Journal of Extension
New Jersey is known as the Garden State, but with over 130 miles of Atlantic coastline, it also has very productive marine ecosystems that offer numerous opportunities for recreational marine fishing. The International Game Fish Association, a nonprofit organization committed to the conservation of game fish and the promotion of responsible, ethical angling practices, collaborated with Rutgers Cooperative Extension to host a youth educational program entitled Reel Into Fishing! The objective is to educate participants through hands-on engagement on ethical fishing practices and marine science to help develop the next generation of responsible anglers.
Material Affecting Design (Mad): How Living Biomaterials Reshape Computational Design Through Biological Transformation, Abolhassan Pishahang
Material Affecting Design (Mad): How Living Biomaterials Reshape Computational Design Through Biological Transformation, Abolhassan Pishahang
Electronic Theses and Dissertations
Living biomaterials grow during fabrication, making strategy selection a design problem distinct from conventional form-making. This dissertation investigates how Pleurotus ostreatus mycelium and Triticum aestivum plant roots reshape the computational design process through their biological behavior. The central argument is that when a designer works with living matter, the material participates in forming, changing the decisions made, the strategies chosen, and the framework required. This relationship between biological transformation and computational design is named the Material Affecting Design (MAD) framework. The research was conducted through a research-through-design methodology grounded in American pragmatist philosophy, particularly the work of Dewey, James, and …
Career: New Insights Into The Ancient Carbon Cycle From Siliceous Deep-Sea Sediments, Donald Penman
Career: New Insights Into The Ancient Carbon Cycle From Siliceous Deep-Sea Sediments, Donald Penman
Funded Research Records
No abstract provided.
Summer Research Internships In Agricultural Biotechnology For Off-Campus Undergraduate Students, Aaron J. Thomas
Summer Research Internships In Agricultural Biotechnology For Off-Campus Undergraduate Students, Aaron J. Thomas
Funded Research Records
No abstract provided.
Inhibiting Chikungunya Virus Protease Using Mtase-Like Domain Interactions For Novel Antiviral Therapies, Justin G. Julander
Inhibiting Chikungunya Virus Protease Using Mtase-Like Domain Interactions For Novel Antiviral Therapies, Justin G. Julander
Funded Research Records
No abstract provided.
Functional Divergence Of Capicua Isoforms Explains Differential Tissue Vulnerability In Neurological Disease, Hamin Lee, Esmeralda Villavicencio Gonzalez, Elias M Rivera, Mark A Durham, Ronald Richman, Elizabeth H-Y Chu, Kailey Xia, Hu Chen, Zhandong Liu, Surabi Veeraragavan, Binoy Shivanna, Huda Y Zoghbi
Functional Divergence Of Capicua Isoforms Explains Differential Tissue Vulnerability In Neurological Disease, Hamin Lee, Esmeralda Villavicencio Gonzalez, Elias M Rivera, Mark A Durham, Ronald Richman, Elizabeth H-Y Chu, Kailey Xia, Hu Chen, Zhandong Liu, Surabi Veeraragavan, Binoy Shivanna, Huda Y Zoghbi
Faculty, Staff and Students Publications
Many neurological diseases impact specific brain regions despite widespread expression of the disease-related protein. Spinocerebellar ataxia type 1 (SCA1) primarily affects the cerebellum, though Ataxin-1 (ATXN1) is widely expressed. We previously showed that intensified interaction between mutant ATXN1 and Capicua (CIC) drives SCA1 pathogenesis in the cerebellum, whereas ATXN1 loss augments amyloid β production in the hippocampus and cortex. CIC, however, forms a complex with ATXN1 and its paralog, Ataxin-1-like (ATXN1L), yet knockout of either yields completely different phenotypes. To determine whether this could be due to CIC having two isoforms, we generated mice bearing either the long (CIC-L) or …