Digital Commons Network^™

Strengthening Ocean Literacy: Marine Science Education And Training To Ensure Australia's Blue Future, Prue Francis, Rachel Kelly, Louise Swanson, Tanveer M. Adyel, Benjamin Arthur, Kirsten Benkendorff, Melanie J. Bishop, Helen Bostock, Marnie L. Campbell, Emma Church, Corrine Condie, Vaibhavi Dwivedi, Michelle Dyer, Matthew England, Liam Fullbrook, Charlie Huveneers, Malcolm Johnson, Brianna Le Busque, Rebecca R. Mcintosh, Amelie Meyer, Benjamin Mos, Jana Mrazova, Allyson O'Brien, Gretta T. Pecl, Amandine Schaeffer, Rebecca J. Shellock, Grant A. Smith, Scott Smithers, Ana Vila-Concejo, Graham Wood

Research outputs 2022 to 2026

This white paper sets out a national vision for advancing ocean literacy in Australia and outlines the role of marine science in fostering an informed, engaged society capable of addressing the challenges and opportunities of our changing oceans. As environmental pressures intensify, and marine resource demands increase, Australians’ capacity to engage with ocean issues, understand risks and opportunities, and participate in marine decision-making has never been more urgent. Marine science will play a central role in building ocean literacy by delivering credible, actionable science, and strengthening education and training systems that enhance understanding of, and connection to, the ocean. Our …

A Metabolite-Dependent Mechanism By Which Bifidobacterium Animalis Subsp. Lactis Promotes Bacteroides Colonization, Khashayar Shahin, Liang Wang, Zihan He, Bomin Lv, Arya Van Alin, Richard Lo-Man, Hao Wu, Philippe Sansonetti, Jean Marc Collard

Research outputs 2022 to 2026

Prokaryote-prokaryote symbiotic relationships influence interactions within microbial communities, affecting colonization, survival, and organization. Unlike competition, consortium species facilitate growth via metabolite cross-feeding. This study explored interactions between two early human gut colonizers: partially aerotolerant Bifidobacterium spp. and strict anaerobic Bacteroides spp., using omics techniques. Promotion of Bacteroides spp. growth by Bifidobacterium animalis subsp. lactis was demonstrated through co-culture experiments in anaerobic conditions. Metabolomic analysis revealed over 150 unique metabolites present in B. animalis subsp. lactis supernatants are absent in other Bifidobacterium species, including 3-hydroxycapric acid, D-alanyl-D-alanine, 2-isopropylmalic acid, and D-glucose 2-phosphate. These compounds served as nutritional substrates, including carbon and …

Cardiovascular–Kidney–Metabolic Syndrome Through The Lens Of Gut‑Derived Uremic Toxins, Chudan Xu, Matthew Snelson, Francine Z. Marques

Research outputs 2022 to 2026

Cardiovascular–Kidney–Metabolic (CKM) syndrome represents a complex, interconnected cluster of cardiovascular disease, chronic kidney disease, and metabolic disorders such as obesity and type 2 diabetes. These conditions share overlapping metabolic, inflammatory, and vascular pathways, with the gut microbiome increasingly recognised as a key contributor and common underlying risk factor. Uremic toxins, traditionally considered waste products of host and microbial metabolism, are now recognised as active mediators of tissue damage across the CKM spectrum, particularly in the context of impaired renal function. Their production and accumulation are amplified by disrupted intestinal barrier integrity, chronic inflammation, and reduced renal clearance, collectively driving systemic …

Development Of A Clinical Prediction Model To Guide The Selective Use Of Spect/Ct In Papillary Thyroid Cancer, Liya Zhu, Junik Son, Lu Wang, Haifeng Hou, Byeong Cheol Ahn

Research outputs 2022 to 2026

Background: Radioiodine whole-body scan (WBS) is routinely performed after radioiodine therapy in papillary thyroid cancer (PTC), but its two-dimensional nature limits anatomical localization. The addition of single-photon emission computed tomography/computed tomography (SPECT/CT) improves diagnostic accuracy; however, routine use exposes patients to additional radiation, longer imaging time, and higher costs. This study aimed to establish a predictive model to identify which patients with PTC are more likely to benefit by adding SPECT/CT imaging after WBS, enabling selective rather than routine use. Methods: This retrospective study included 265 patients with pathologically confirmed PTC who underwent postoperative radioiodine therapy followed by WBS and …

Diasporic Challenges, Domestic Abuse And Patriarchal Norms Experienced By Migrant Pakistani Women In Australia, Safia Iftikhar, Shajimon Peter, Vicki Banham, Elizabeth Reid Boyd

Research outputs 2022 to 2026

This article examines diasporic challenges, domestic abuse and patriarchal ideologies that constitute unique diasporic lives of first-generation migrant married Pakistani women (MPW) in Australia. For this qualitative study, 21 MPW residing in Australia were recruited for semi-structured in-depth interviews. Results from the interpretative phenomenological analysis of data revealed the diasporic encounters MPW face in Australia and the influence of patriarchal ideology on their lives in navigating those encounters. MPW’s responses to patriarchal norms in their married lives fell on a spectrum, which include conformation to the norms of patriarchal familial structures on the one side and resistance and bargaining against …

The Value Of Saltbush Revegetation For Biodiversity In A Highly Fragmented Landscape, Robert A. Davis, Michael D. Craig, Tim S. Doherty, Jonathan D. Majer, Eddie J.B. Van Etten

Research outputs 2022 to 2026

Secondary salinization is a significant global issue affecting up to 1 billion hectares of land, impacting biodiversity and particularly vegetation. One form of revegetation that can provide a return to landholders is saltbush (Atriplex spp.), which provides forage for a wide range of livestock. The effectiveness of saltbush plantings in providing useful habitat for fauna in agricultural landscapes suffering from secondary salinity is poorly understood. We aimed to address this knowledge gap by surveying bird, ant, and spider communities, and quantifying vegetation structure and floristic composition in saltbush and native woodlands in agricultural landscapes affected by secondary salinization in Western …

Prevalence Of Dementia In Selected Middle East And North Africa (Mena) Countries: A Systematic Review And Meta-Analysis, Mohsen Sedighi, Mohammad Hasan Shahabi, Alireza Amanollahi, Khurshid Alam, Soudabeh Shemehsavar, Zahra Shirzadi, Serena Sabatini, Ahmad R. Khatoonabadi, Matthew Prina, Akram A. Hosseini, Claire V. Burley, Jennifer Dunne, Simin Mahinrad, Iman Dajani, Ralph N. Martins, Blossom C.M. Stephan, Ali Chaari, Hamid R. Sohrabi

Research outputs 2022 to 2026

Data on dementia epidemiology in the Middle East and North Africa (MENA) region is limited. This systematic review and meta-analysis examined dementia prevalence across MENA. Databases were searched up to October 2024. Analyses were stratified by country and sex. Pooled prevalence was estimated using a random-effects model with a 95% confidence interval (CI). Fifty-two studies on the selected countries met inclusion criteria, covering 87,219 individuals with dementia from a total population of 1,045,908. The pooled prevalence was 12.16% (95% CI: 9.61–14.96) for the region and the Israel had the highest prevalence (17.00%), followed by Iran (13.20%), Turkey (11.40%), Saudi Arabia …

Negotiating Relationships With Food, The Body, And Physical Activity: Who Is The Healthiest Of Them All?, Valeria Varea, Victoria Evans, Dawn Penney, Eibhlish O'Hara

Research outputs 2022 to 2026

Healthy eating and regular exercise are things that many people aspire to, mainly for health reasons. However, these practices can be complex given broader societal discourses. This paper aims to critically interrogate the social conditions and discursive formations that underpin everyday exercisers’ relationships with food, the body, and physical activity by using biopower and biopedagogies as a theoretical approach, and healthism as a set of discourses. Photo elicitation interviews with vignettes were conducted with nine participants who were regular exercisers. We constructed three different scenarios from the interview data and the theoretical approach: 1. Anna: A performance-driven, health compliant, private …

Precision Exercise For Breast Cancer-Related Outcomes: Towards Personalised Training Based On Tumour, Treatment And Patient Characteristics, Cristina Crespo-Garcia, Anita Borsati, Dennis R. Taaffe, Carolyn J. Peddle-Mcintyre, John P. Campbell, Alice Avancini, Emily Jeffery, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Exercise is a promising strategy associated with improved cancer-related outcomes through multiple biological mechanisms. However, current exercise guidelines largely adopt a one-size-fits-all approach and overlook inter-individual variability in response. Given the heterogeneity of breast cancer, precision exercise prescriptions may better target biological pathways linked to therapeutic efficacy and long-term prognosis. Observational studies consistently show that higher physical activity levels are associated with improved survival outcomes, including reduced all-cause and breast cancer-specific mortality. In contrast, evidence from interventional trials remains limited and inconsistent, with effects on tumour response and survival largely derived from secondary or exploratory analyses. These discrepancies likely reflect …

Thinking With Trees: Responding To Sympoietic Plant Relations Through Visual Art, Xiaoyu Yang

Research outputs 2022 to 2026

Societal Impact Statement: Amid escalating climate crises, this paper explores how we might rethink our relationship with the natural world, particularly with plants and trees, through the perspectives of visual art. This paper reveals how art invites us to see trees and other plant life not as passive background scenery, but as living beings with their own forms of experience and individuality. Rather than offering technical solutions to the climate crisis, visual art creates something equally important: a shift in how we think and feel about ‘othering’ non-human life. By making visible the inner lives and behaviours of plants, art …

Creatine Monohydrate For Lean Mass, Strength, And Bone Density In Postmenopausal Women: A Systematic Review And Meta-Analysis, Siavash Naddafha, Jose Antonio, Richard B. Kreider, Jeffrey R. Stout

Research outputs 2022 to 2026

Background: Menopause is accompanied by accelerated losses in muscle mass and strength and declining bone density. Whether creatine monohydrate benefits postmenopausal women are uncertain. Methods: We systematically reviewed randomized, placebo-controlled trials examining creatine supplementation, with or without resistance training (RT), in postmenopausal women. MEDLINE, Embase, Scopus, Web of Science, SPORTDiscus, and Cochrane CENTRAL were searched from 2000 to August 2025, supplemented by trial registries and reference-list screening. Eligible studies included postmenopausal women aged ≥40–45 years, intervention durations ≥6 weeks for primary analyses, and outcomes including DXA-derived lean mass, one-repetition maximum (1RM) strength, bone mineral density, physical function, and safety. Dual …

Enhancing Physical Performance With Ischemic Preconditioning: A Systematic Review And Meta-Analysis Of Moderators And Performance Outcomes, Yilin Zhang, Kai Xu, Hao Kong, Mingyue Yin, Chenghao Liu, Yun Xie, Liam Kilduff, Gustavo R. Mota, Olivier Girard

Research outputs 2022 to 2026

This study examined the effects of ischemic preconditioning (IPC) on physical performance, considering the influence of timing, warm-up (WU), participant characteristics, and IPC protocols structure. A total of 90 trials (1,439 participants) were retrieved from three databases and assessed using PICOS criteria. Multilevel meta-analyses with cluster-robust variance adjustments were conducted to calculate pooled effect sizes (Hedge’s g). Risk of bias and certainty of evidence were assessed using the RoB 2 tool and GRADE framework. IPC produced a trivial but significant improvement in physical performance (g = 0.13, P < 0.01), which persisted after excluding SHAM effects (g = 0.10; P < 0.01). Significant improvements were observed for maximum repetitions, time to failure, and power output, but not for jump ability, strength, or oxygen uptake. Comparable benefits were found for anaerobic (g = 0.15) and aerobic (g = 0.10) exercise, with greater effects in males and less-trained participants. Performance was further enhanced when IPC was followed by WU (g = 0.16), with the optimal IPC-to-WU interval being ~42 minutes. Without WU, the effective IPC window narrowed to 6–7 minutes. In practice, IPC can enhance physical performance, independently of sham effects, moderated by sex, training level, and WU. For competition or testing, the most effective strategy appears to be 3 or 4 × 5-min IPC protocol, followed by a 42-min interval, standardized warm-up, and endurance testing. For mechanistic studies, WU should be excluded, and testing conducted 6-7 minutes post-IPC. Future research should target women, middle-aged individuals, and elite athletes.

Missing Planktivore Functions Drive Global Variation In Reef Fish Productivity, James Gahan, Helen F. Yan, David R. Bellwood, Graham J. Edgar, Leo T. Nankervis, Alexandre C. Siqueira, Rick D. Stuart-Smith, Sterling B. Tebbett

Research outputs 2022 to 2026

The functioning of high-diversity ecosystems, such as coral reefs, is intrinsically tied to the integrity and efficiency of the trophic pathways within these systems. Coral reef productivity depends, in part, on the input of external nutrients, primarily zooplankton, that is assimilated by extraordinarily diverse fish communities. The plankton–planktivore trophic pathway is thus crucial for sustaining the productivity that exemplifies coral reef ecosystems; however, it remains poorly understood at large spatial scales. Here we explore global patterns in reef fish community structure, revealing a major discrepancy between the Indo-Pacific and Caribbean in the productivity and fisheries potential of planktivorous reef fishes. …

Tinjauan Frasa “Setiap Orang” Dalam Pasal 3 Ayat (1) Peraturan Pemerintah Nomor 56 Tahun 2021 Tentang Pengelolaan Royalti Hak Cipta Lagu Dan/Atau Musik, Fajar Hidayansyah Ilham, Luna Dezeana Ticoalu

Jurnal Hukum & Pembangunan

Copyright is one form of legal protection for intellectual works, occupying an important position within the intellectual property law system. The Copyright Law explicitly grants exclusive rights to creators, encompassing both moral rights and economic rights. Economic rights, as stipulated in Article 9 paragraph (1), allow creators to obtain economic benefits from their works, ranging from publication, reproduction, distribution, performance, to communication to the public. This provision shows that creators hold a primary position as legal subjects entitled to protection, while also serving as central actors in the creative industry ecosystem. In practice, the mechanism for copyright protection requires implementing …

Competitive And Priority Effects Of Native Cool-Season Grasses On Invasive Bromus Species In The Northern Great Plains, Tyler Michael Geltmacher

Electronic Theses and Dissertations

Native grasslands and restoration sites in the Northern Great Plains face pressure from invasive cool-season grass species, such as smooth brome (Bromus inermis) and cheatgrass (Bromus tectorum). Native cool-season grass species may compete in the same niche as the invaders and provide resistance to invasion of existing or restored grasslands. Green needlegrass (Nassella viridula) and junegrass (Koeleria macrantha) were evaluated in this study for competitive effect and priority effect against invasive bromes to inform management decisions. Greenhouse studies were conducted to evaluate competitive ability of the two native species as well as how priority influences competition. In my first chapter, …

Ai-Assisted Wheat Spike And Spikelet Detection And Density Mapping Using Multiscale Remote Sensing Data To Support Wheat Grain Yield Forecasting, Hillson Ghimire

Electronic Theses and Dissertations

Wheat grain yield is determined by the number of spikes per unit area, the number of grains per spike, and kernel weight. However, spike number and spikelets per spike are still measured predominantly through manual counting, a labor-intensive and subjective process that limits phenotyping throughput and selection intensity in modern wheat breeding programs. This thesis develops and evaluates a deep learning framework for automated, high-throughput phenotyping of wheat spike and spikelet traits across complementary imaging scales and implements the framework as a deployable platform. First, two large-scale benchmark datasets with oriented bounding box (OBB) annotations were established, comprising 48,521 spike …

Longitudinal Associations And Interactions Of Adolescent Religious Deidentification And Parental Sanctification On Parent-Adolescent Relationships, Justin Hendricks, Sam A. Hardy, Michael A. Goodman, Emily De Schweintiz Taylor

Faculty Publications

In many religious families, shared religious identity is a strong source of intergenerational solidarity. However, when adolescents deidentify from their family faith, normative parent-adolescent conflict, which heightens in mid-adolescence and normally subsides in late-adolescence, may intensify and damage parent-adolescent social cohesion. Many religious parents view parenting relationships as sanctified, which typically leads to adaptive parenting, but in the context of deidentification may lead to greater distress. To understand how adolescent religious deidentification influences parentadolescent relationships, we examined the longitudinal associations and interactions of adolescent children’s religious deidentification and parental sanctification on parent-child religious conflict and parental warmth (N = 1,391 …

Evaluating Supplementation Strategies Using Precision Livestock Technologies And Energy Based Models In Developing Beef Heifers Grazing Dormant Rangeland, Kali-Jo Bentz

Electronic Theses and Dissertations

Replacement beef heifer development in extensive grazing systems is challenged by variation in forage quality, supplement intake, and animal behavior, all of which influence the ability to achieve targeted growth prior to breeding. Precision livestock technologies (PLT) enable continuous monitoring of individual animal performance, while energy-based nutritional models support individualized supplementation. However, their application under extensive grazing conditions remains poorly understood. Therefore, the objectives of this thesis were to (1) evaluate heifer utilization of multiple precision livestock technologies and their relationship with animal performance and (2) evaluate the accuracy of an individualized energy-based supplementation model by comparing predicted supplement allotments …

On The Edge Of Science?: Commentary On Birch On Edge Of Sentience, Mark Briffa, Lynne U. Sneddon

School of Biological and Marine Sciences

In The Edge of Sentience, Jonathan Birch (2024) provides a thought-provokingsynthesis of current perspectives on animal (and artificial) sentience. He addresses the question from conceptual, ethical, regulatory and empirical viewpoints. Here we focus on some of the scientific issues raised, including defining and operationalising the concept of sentience and the implications for policy and regulation. Despite unresolved conceptual challenges, the book makes a compelling case for the continued scientific investigation of animal sentience.

Plant-Insect Interactions In Great Plains Restoration And Invasion Ecology, Joseph H. Cammarano

Electronic Theses and Dissertations

Prairie ecosystem loss and invasive plant species are major ecological problems in the Great Plains. Plant-insect interactions have important consequences for both the restoration of prairie ecosystems and management of invasive plant species. Pollinating insects are vital to the sustainability of prairie ecosystems, and herbivorous insects can provide biological control of invasive plant species. Understanding how restoration strategies may influence potential pollinator communities can have important consequences for restoration sustainability and success and understanding how biological control strategies may help manage invasive plant populations can also help land managers reach restoration and conservation goals. In Ch. 2, I sought to …

Enzyme Susceptibility And Functionality Of High Protein Retentates And Reconstituted Ingredients, Khushi Dubey

Electronic Theses and Dissertations

This thesis explores the effects of processing history on the enzymatic susceptibility and functional properties of high-protein dairy ingredients, with a specific focus on ultrafiltered (UF) and microfiltered (MF) retentates and spray-dried powders. While retentates and powders are often used interchangeably in industrial applications, processing steps, such as drying, can induce structural and physicochemical changes that affect protein functionality and enzyme accessibility. Milk protein concentrates (MPC) and micellar casein concentrates (MCC) were standardized to 10% protein and subjected to enzymatic treatments, including proteolysis (Alcalase and rennet) and crosslinking (transglutaminase and laccase). Structural modifications were evaluated using capillary gel electrophoresis, non-protein …

Tau In Alzheimer’S Disease: Shaping The Future Patient Journey, Catherine J Mummery, Christopher Chen Li-Hsian, Cristian A Lasagna-Reeves, Rik Ossenkoppele, Christopher C Rowe, Douglas W Scharre, Huali Wang, Simon Kyaga, Jeffrey L Cummings

Faculty, Staff and Students Publications

Alzheimer's disease is a complex and multifactorial disease characterized by two key pathological hallmarks: amyloid-beta plaques and tau neurofibrillary tangles. Recent progress has led to the development and approval of disease-targeted therapies for Alzheimer's disease in the form of anti-amyloid-beta monoclonal antibodies. However, findings suggest that amelioration of multiple pathological drivers may be required to maximize clinical effect. An increasing body of evidence suggests that tau is a critical player in Alzheimer's disease pathophysiology, contributing significantly to neurodegeneration and cognitive decline. There are now several tau-targeting drugs in clinical development. In this review, we build on research and advancements in …

Esophageal Myotomy And Risk Of Esophageal Cancer And Mortality In Achalasia: Real-World Cohort Study, Fouad Jaber, Mohamad Ali Ibrahim, Mohammed Jaber, Youssef Soliman, Mai A Khalaf, Tara Keihanian, Fares Ayoub, Mohamed O Othman, Salmaan Jawaid

Faculty, Staff and Students Publications

Background and study aims: Achalasia is associated with increased risk of esophageal cancer, particularly squamous cell carcinoma. Although esophageal myotomy improves dysphagia, its impact on cancer risk and mortality remains unclear.

Patients and methods: We conducted a retrospective cohort study using the TriNetX research network, including adults (≥ 18 years) with achalasia confirmed by esophageal manometry. Patients were categorized based on treatment of those undergoing esophageal myotomy (peroral endoscopic myotomy [POEM] or laparoscopic Heller myotomy [LHM]) and those managed without myotomy. Patients with prior esophagectomy or malignancies associated with increased esophageal cancer risk were excluded. The primary outcome was incident …

Long Covid And Cardiovascular Diseases Among U.S. Adults: Results From The U.S. Medical Expenditure Panel Survey, Geoffrey Y Zhang, John C Lin, Dang Nguyen, Sameed Ahmed M Khatana, Thomas P Giordano

Faculty, Staff and Students Publications

Objective: Long COVID is associated with persistent symptoms including cardiovascular complications; however, the epidemiology and directionality of this association remain unclear.

Methods: Utilizing a retrospective cohort study design with cross-sectional analyses, 8,332 respondents aged 18 and older from the 2022 Medical Expenditure Panel Survey (MEPS) who had a prior COVID-19 infection, were analyzed to determine the temporal association between long COVID and cardiovascular disease (CVD), modeling each as both outcome and exposure in separate analyses.

Results: Long COVID was associated with any CVD diagnosis (OR 1.37; 95% CI: 1.05-1.80), specifically angina (OR 1.81; 95% CI: 1.18-2.77) and myocardial infarction (OR …

Astrocytic Sox9 Overexpression In Alzheimer’S Disease Mouse Models Promotes Aβ Plaque Phagocytosis And Preserves Cognitive Function, Dong-Joo Choi, Sanjana Murali, Wookbong Kwon, Junsung Woo, Eun-Ah Christine Song, Yeunjung Ko, Debosmita Sardar, Brittney Lozzi, Yi-Ting Cheng, Michael R Williamson, Teng-Wei Huang, Kaitlyn Sanchez, Joanna Jankowsky, Benjamin Deneen

Faculty, Staff and Students Publications

Astrocytes play essential roles in the brain, and their dysfunction is associated with nearly every form of neurological disease. Despite their ubiquity, knowledge of how astrocytes contribute to disease pathogenesis is incomplete; accordingly, harnessing their biology toward therapeutics remains a major challenge. Here we show that the transcription factor Sox9 plays a context-specific role in maintaining astrocyte function and circuit activity in the aging hippocampus and Alzheimer's disease (AD) models. We found that Sox9 overexpression in astrocytes in AD models clears existing amyloid beta (Aβ) plaques and preserves cognitive function. Mechanistically, Sox9 promotes the phagocytosis of Aβ plaques by astrocytes …

Toward Ethical Provenance Tracking: The Ga4gh Model Data Access Agreement (Daa), Alexander Bernier, Bartha Maria Knoppers, Jonathan Lawson, Robyn Mcdougall, Maili Raven-Adams, Vasiliki Rahimzadeh

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Standardizing contractual clauses that govern data access enables research institutions to responsibly steward genomic and related health data while enabling its efficient downstream reuse.

Methods: We describe a document analysis study using both qualitative and comparative law analytical approaches to identify the most common categories of clauses from 29 different data access agreements used by human biomedical research consortia globally. We furthermore characterized the legal positions and standard practices for each common element of the agreement and synthesized across them to develop model clauses. A total of 3 discussion sessions were organized virtually to refine the clauses among members …

Imagining Genomics And Population Health In 2050: Anticipating Future Research, Policy, And Governance Needs, Bartha Maria Knoppers, Yann Joly, Ma Apos N H Zawati, Habiba Alsafar, Jeffrey C Barrett, Laura Blackburn, Brian Hon-Yin Chung, Martina C Cornel, Edward S Dove, David Glazer, Calvin Wai-Loon Ho, Muin J Khoury, Anna C F Lewis, Anneke Lucassen, Peter F R Mills, Colin Mitchell, Nicola Mulder, Ainsley J Newson, Anthony Ng, Paul D P Pharoah, Vasiliki Rahimzadeh, Megan C Roberts, Saskia C Sanderson, Jeffrey M Skopek, Ron Zimmern, Eric M Meslin

Center for Medical Ethics and Health Policy Staff Publications

No abstract provided.

Access To Digital Health Technologies: Personalized Framework And Global Perspectives, Sanjiv M Narayan, Mina K Chung, Demilade Adedinsewo, Luisa C C Brant, Leslie L Davis, David Duncker, Jennifer L Hall, Janet K Han, Carolyn S P Lam, Eldrin Lewis, Joseph Loscalzo, Manlio F Márquez, Vasiliki Rahimzadeh, Fatima Rodriguez, Prashanthan Sanders, Emma Svennberg, Kenneth Stein, Mintu Turakhia, Clyde Yancy, Antonis A Armoundas

Center for Medical Ethics and Health Policy Staff Publications

The emergence and rapid adoption of digital health technologies (DHT) present unprecedented opportunities to democratize and reduce disparities in health care by monitoring health and disease at the point of care in all patients. However, limited access to DHT is becoming a major obstacle to realizing these goals. Access to DHT is influenced not only by well-recognized social determinants of health, but also by digital determinants of health, such as digital literacy and the need for broad access to digital infrastructure, as well as commercial and economic factors. Addressing these challenges and designing unbiased systems of care are essential to …

Clinical Informatics Education To Advance Learning Health Systems: A Scoping Review, Alexandra Zingg, L Ida Tovar, Laura Witte, Kelsey L Koym, Kyler Godwin

Library Staff Publications

Introduction: Learning health systems leverage clinical data and knowledge to advance healthcare quality. Effective training in informatics concepts and tools is essential for medical trainees to become health system experts and contributors to positive organizational change. The objective of this study is to summarize characteristics of existing clinical informatics training programs and map these to recommended Learning Health System informatics competencies. We aim to answer the following research questions: (1) How are academic medical institutions implementing informatics education initiatives for medical trainees? (2) Are these initiatives implementing recommended informatics competencies? and (3) How effective are these initiatives according to established …

Genome-Wide Gene-Sleep Interaction Study Identifies Novel Lipid Loci In 732,564 Participants, Raymond Noordam, Wenyi Wang, Pavithra Nagarajan, Heming Wang, Michael R Brown, Amy R Bentley, Qin Hui, Aldi T Kraja, John L Morrison, Jeffrey R O'Connel, Songmi Lee, Karen Schwander, Traci M Bartz, Lisa De Las Fuentes, Mary F Feitosa, Xiuqing Guo, Xu Hanfei, Sarah E Harris, Zhijie Huang, Mart Kals, Christophe Lefevre, Massimo Mangino, Yuri Milaneschi, Peter J Van Der Most, Natasha L Pacheco, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Quan Sun, Yasuharu Tabara, Dina Vojinovic, Yujie Wang, Stefan Weiss, Qian Yang, Wei Zhao, Wanying Zhu, Md Abu Yusuf Ansari, Hugues Aschard, Pramod Anugu, Themistocles L Assimes, John Attia, Laura D Baker, Christie Ballantyne, Lydia Bazzano, Eric Boerwinkle, Brain Cade, Hung-Hsin Chen, Wei Chen, Yii-Der Ida Chen, Zekai Chen, Kelly Cho, Ileana De Anda-Duran, Latchezar Dimitrov, Anh Do, Todd Edwards, Tariq Faquih, Aroon Hingorani, Susan P Fisher-Hoch, J Michael Gaziano, Sina A Gharib, Ayush Giri, Mohsen Ghanbari, Hans Jörgen Grabe, Mariaelisa Graff, C Charles Gu, Jiang He, Sami Heikkinen, James Hixson, Yuk-Lam Ho, Michelle M Hood, Serena C Houghton, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Tuomas O Kilpeläinen, Pirjo Komulainen, Henry J Lin, Gregorio V Linchangco, Annemarie I Luik, Jintao Ma, James B Meigs, Joseph B Mccormick, Cristina Menni, Ilja M Nolte, Jill M Norris, Lauren E Petty, Hannah G Polikowsky, Laura M Raffield, Stephen S Rich, Renata L Riha, Thomas C Russ, Edward A Ruiz-Narvaez, Colleen M Sitlani, Jennifer A Smith, Harold Snieder, Tamar Sofer, Botong Shen, Jingxian Tang, Kent D Taylor, Maris Teder-Laving, Rima Triatin, Michael Y Tsai, Henry Völzke, Kenneth E Westerman, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Alan B Zonderman, Xiaofeng Zhu, Jennifer E Below, Simon R Cox, Michelle Evans, Myriam Fornage, Ervin R Fox, Nora Franceschini, Sioban D Harlow, Elizabeth Holliday, M Arfan Ikram, Tanika Kelly, Timo A Lakka, Deborah A Lawlor, Changwei Li, Ching-Ti Liu, Reedik Mägi, Alisa K Manning, Fumihiko Matsuda, Alanna C Morrison, Matthias Nauck, Kari E North, Brenda Wjh Penninx, Michael A Province, Bruce M Psaty, Jerome I Rotter, Tim D Spector, Lynne E Wagenknecht, Ko Willems Van Dijk, Lifelines Cohort Study, Million Veteran Program, Cashell E Jaquish, Peter Wf Wilson, Patricia A Peyser, Patricia B Munroe, Paul S De Vries, W James Gauderman, Yan V Sun, Han Chen, Clint L Miller, Thomas W Winkler, Dabeeru C Rao, Susan Redline, Diana Van Heemst

Faculty, Staff and Student Publications

Background and aims: Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets.

Methods: We collected data from 55 cohorts with a combined sample size of 732,564 participants (87 % European ancestry) with data on lipid traits (high-density lipoprotein [HDL-c] and low-density lipoprotein [LDL-c] cholesterol and triglycerides [TG]). Short (STST) and long (LTST) …