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2026

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Establishing And Validating Foundational Competencies In The Application Of Behavioral Gerontology Through Expert Consensus, Alexandra Doran Aug 2026

Establishing And Validating Foundational Competencies In The Application Of Behavioral Gerontology Through Expert Consensus, Alexandra Doran

Dissertations

Behavioral gerontology continues to evolve and grow as an application of behavior analysis, but there remains a critical need to define competencies necessary for behavior analysts to provide ethical, effective care within their scope of competence. This study sought to establish and validate foundational competencies for Board Certified Behavior Analyst s® (BCBA s® ) working in this area. A mixed-methods design using three experiments was used. In Experiment 1, a review of discipline-specific competency frameworks and a job mapping process yielded a preliminary set of behavior-analytic competencies for behavioral gerontology. This produced a preliminary framework consisting of 142 competencies. Experiment …


Analysis Of A Process-Based Approach To Case Formulation And Treatment With Acceptance And Commitment Therapy, Callum Smith Aug 2026

Analysis Of A Process-Based Approach To Case Formulation And Treatment With Acceptance And Commitment Therapy, Callum Smith

Dissertations

Process-Based Therapy (PBT) is a novel approach to clinical research and practice. PBT is proposed as an alternative model to classic diagnostic frameworks. It emphasizes conceptualizing psychological problems through adaptive and maladaptive processes of change. The aim of current PBT research is to develop reliable methods of organizing change processes into network models. In network models, change processes are presented in nodes connected by lines and arrows to represent the interacting relationships between those processes for a given individual. The present project aims to evaluate the inter-rater reliability and predictive validity of a novel semi-structured interview method to aid in …


The Impact Of Using History On Learning In Physics Laboratory Settings, Patrick W. Clouse Aug 2026

The Impact Of Using History On Learning In Physics Laboratory Settings, Patrick W. Clouse

Dissertations

Integrating History of Science (HOS) into science courses has many benefits. Students demonstrate improved scientific content knowledge, develop their understanding of Nature of Science (NOS), and improve their attitudes towards science. However, barriers prevent instructors from effectively incorporating history into their teaching. The traditions and culture of science instruction, individual teacher attitudes and skills, existing institutional frameworks, and prevailing curricular materials all prevent HOS integration. Preservice teachers may never be exposed to HOS in their science or education courses, meaning they lack experience and knowledge surrounding the benefits of HOS. Therefore, alternative avenues for effective integration should be considered to …


Melatonin-Functionalized Silver Nanoparticles Enhance Salinity Tolerance In Brassica Juncea By Modulating Antioxidant Defence And Growth Physiology, Mohini Yadav, Manar Fawzi Bani Mfarrej, Vikash Kumar, Ankita Singh, Faheem Ahmad, Saurabh C. Saxena Aug 2026

Melatonin-Functionalized Silver Nanoparticles Enhance Salinity Tolerance In Brassica Juncea By Modulating Antioxidant Defence And Growth Physiology, Mohini Yadav, Manar Fawzi Bani Mfarrej, Vikash Kumar, Ankita Singh, Faheem Ahmad, Saurabh C. Saxena

All Works

Soil salinity is a major abiotic stress that severely limits plant growth and productivity by inducing osmotic stress, oxidative damage, and ionic imbalances. The present study evaluated the potential of melatonin-mediated silver nanoparticles (Mel AgNPs) to enhance salinity stress tolerance in Brassica juncea. Pot experiments were conducted using 21-day-old plants exposed to salinity stress and treated with Mel AgNPs at different concentrations (50 and 100 mg L⁻¹) through both root application and foliar spray. Morphological, physiological, and biochemical responses were assessed 48 h after nanoparticle exposure. Salinity stress markedly increased lipid peroxidation and hydrogen peroxide accumulation while suppressing antioxidant defence. …


Using Life-History Information To Identify Management Priorities Within An Emergent Multi-Species Grey Mullet Fishery, Calum J. Pritchard, Ayşegül Tuğçe Han, Andrew Macleod, Rachel M. Turnbull, Jamie Small, Sarah Birchenough, Simon Pengelly, Benjamin J. Ciotti Aug 2026

Using Life-History Information To Identify Management Priorities Within An Emergent Multi-Species Grey Mullet Fishery, Calum J. Pritchard, Ayşegül Tuğçe Han, Andrew Macleod, Rachel M. Turnbull, Jamie Small, Sarah Birchenough, Simon Pengelly, Benjamin J. Ciotti

School of Biological and Marine Sciences

Three grey mullets are native to the United Kingdom: Chelon labrosus, Chelon ramada, and Chelon auratus, for which there is an emergent fishery. These species are managed under a broad grey mullet fishery, but aspects of the life-histories of these populations remain undetermined. The fishery has never been formally assessed. For each species, this research i) investigated their life-history, ii) quantified relative fishing pressure, and iii) investigated their relative vulnerability to overfishing. Grey mullets were collected from commercial fisheries along the southern coast of England. Fish were weighed, measured, and ages were assigned by counting scale annuli. Maturity was determined …


A Review Of Blue Carbon Credit Projects' Socio-Economic Activities, Nata Tavonvunchai, Holly J. Niner, Abigail Mcquatters-Gollop, Siân E. Rees Aug 2026

A Review Of Blue Carbon Credit Projects' Socio-Economic Activities, Nata Tavonvunchai, Holly J. Niner, Abigail Mcquatters-Gollop, Siân E. Rees

School of Biological and Marine Sciences

Coastal ‘blue carbon’ ecosystems (mangroves, seagrasses and saltmarshes) are critical for climate regulation and biodiversity, yet significant funding gaps persist in marine conservation. While blue carbon credits are increasingly used to bridge these gaps, concerns remain regarding their efficacy in delivering socio-economic benefits. Based on lessons from terrestrial carbon markets, failing to prioritise local community needs can lead to inequitable outcomes and externally mandated constraints, which undermine the legitimacy of nature-based solutions. This research seeks to add to the centralised understanding of the social dimension of blue carbon by delivering a comprehensive review of 77 publicly listed projects from global …


Integrating Hydrology And Human Water Footprints: A Case Study Of The Great Salt Lake Basin, Rachel Lynne Seeley Aug 2026

Integrating Hydrology And Human Water Footprints: A Case Study Of The Great Salt Lake Basin, Rachel Lynne Seeley

All Graduate Theses and Dissertations, Fall 2023 to Present

Global demand for water is outrunning supply, and how we account for water is part of the problem. Many water management frameworks are based solely on how much physical water moves through rivers, aquifers, and other water bodies, missing the water that is embedded in food and other products a region produces and exports. This study developed a new, generalizable water accounting framework that incorporates this “hidden water,” known as virtual water, into water management and applied the framework in the Great Salt Lake Basin.

The Great Salt Lake is shrinking, and an often-overlooked driver of the lake’s decline is …


Secure Agricultural Futures: Re-Defining And -Imagining Agricultural Water Landscapes In The Us West, Britta L. Schumacher Aug 2026

Secure Agricultural Futures: Re-Defining And -Imagining Agricultural Water Landscapes In The Us West, Britta L. Schumacher

All Graduate Theses and Dissertations, Fall 2023 to Present

Aridity is swiftly becoming the US West’s new normal. As agricultural communities adjust to persistent growing-season scarcity, they find their livelihoods under increasing threat. This points to the urgency of finding paths toward more secure water futures. A piece of this future puzzle includes water (re-)distribution – taking excess from one place and delivering it to another in need. To begin thinking about (re-)distribution, this dissertation engages with three mixed-methods and multiscale studies. The first study pairs county-level data across the 11 westernmost US states with survey data collected from individual producers in Utah to assess past and current trends …


Advancing Management Strategies For Two Promising Mason Bee Species (Osmia Ribifloris And Osmia Bruneri) For Berry Pollination, Miranda L. Jones Aug 2026

Advancing Management Strategies For Two Promising Mason Bee Species (Osmia Ribifloris And Osmia Bruneri) For Berry Pollination, Miranda L. Jones

All Graduate Theses and Dissertations, Fall 2023 to Present

Bee management can broadly refer to human manipulation of one or multiple parts of a bee’s lifecycle. Managing honey bees, commonly referred to as beekeeping, is responsible for providing most pollination for global food crops. However, using more than one bee species for crop pollination can have many benefits. Benefits include better crop pollination and insurance in case one bee species underperforms or its population collapses. Some bees within the genus Osmia are already widely managed for crop pollination because their developmental lifecycle allows bee managers to readily deploy pollinating bees in sync with varying crop blooms, and for certain …


Visualizing The Phase Space Of Two Interacting Spherical Magnets Via Lagrangian Descriptors, Matthew Pontius Aug 2026

Visualizing The Phase Space Of Two Interacting Spherical Magnets Via Lagrangian Descriptors, Matthew Pontius

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis studies the motion of one spherical magnet sliding on another fixed spherical magnet. Although the setup is simple, the resulting motion can range from regular and predictable to chaotic as the energy increases. To understand this behavior, mathematical tools are used to visualize how all possible motions are organized in phase space. These methods reveal patterns such as stable regions, repeating motions, and chaotic trajectories. The results show how order and chaos coexist in this system and provide insight into how small changes in the initial conditions can lead to very different outcomes.


Evolving Roles: School Counselors Addressing Mental Health In Pk-12 Education, Evin Daines Aug 2026

Evolving Roles: School Counselors Addressing Mental Health In Pk-12 Education, Evin Daines

All Graduate Theses and Dissertations, Fall 2023 to Present

A significant number of children and youth are currently experiencing poor mental health. School counselors work with all students and are in a position to provide support to students experiencing mental health challenges. School counselors can also identify what may hinder children and youth from accessing mental health resources in their communities. This study explores how many school counselors engage in mental health counseling, how school counselors view their roles in addressing student mental health, and what barriers they perceive as keeping children and youth from accessing mental health and behavior services.


An Examination Of Lifetime Traumatic Brain Injury And Anti-Inflammatory Medication Use In The Risk For Alzheimer's Disease, Mikaela A. Drewel Aug 2026

An Examination Of Lifetime Traumatic Brain Injury And Anti-Inflammatory Medication Use In The Risk For Alzheimer's Disease, Mikaela A. Drewel

All Graduate Theses and Dissertations, Fall 2023 to Present

Alzheimer’s disease (AD) is the leading cause of dementia in individuals aged 65 years and older. There are a number of lifestyle and genetic factors that affect one’s risk for AD including traumatic brain injury (TBI), and genes such as those for Apolipoprotein E (APOE) and brain-derived neurotrophic factor (BDNF). This study examined sex differences in how TBI history influences risk for AD, exploring genetic variants suspected to play a role in TBI recovery. Additionally, in following an inflammatory mechanism in TBI, the study also determined if nonsteroidal anti-inflammatory drug (NSAID) use reduced subsequent risk for AD. The study analyzed …


Investigating Recruitment Bottlenecks Of Juvenile Native Fish In The Colorado River Basin, Utah, Anna R. Amidon Aug 2026

Investigating Recruitment Bottlenecks Of Juvenile Native Fish In The Colorado River Basin, Utah, Anna R. Amidon

All Graduate Theses and Dissertations, Fall 2023 to Present

The first year of life is a vulnerable period for most fish species. Whether young fish survive this early stage determines how many individuals eventually survive and grow into reproductive adults, a process called recruitment. In desert rivers like the Colorado River Basin, native fish evolved alongside extreme natural conditions but now face additional pressure from drought and water storage infrastructure, which alter the shoreline habitats on which young fish depend. Long-lived, migratory native species with complex life cycles are especially vulnerable. We used four decades of monitoring data from the Upper Colorado River Basin to evaluate whether young-of-year (YOY, …


Affective And Cognitive Factors Contributing To Male-Female Differences In Mathematics, Sarah N. Herod Aug 2026

Affective And Cognitive Factors Contributing To Male-Female Differences In Mathematics, Sarah N. Herod

All Graduate Theses and Dissertations, Fall 2023 to Present

Math differences between men and women have been studied for several decades, with original theories suggesting a biological reason for the differences and more new ones suggesting multiple factors, such as self-efficacy, anxiety, and spatial ability, may be responsible for these apparent differences. Additionally, most research into math differences between the sexes involves the use of a composite score, rather than examining the different sub-domains of math separately. The purpose of the current study was to examine the relationship between sex and math performance within the context of an individual's belief and attitudes towards math and spatial information. Seventy-one participants …


Nh Dfl - 25 Years Of Hwa - Peterborough_2026_Aug_11, Ryan Crandall Aug 2026

Nh Dfl - 25 Years Of Hwa - Peterborough_2026_Aug_11, Ryan Crandall

UNH Cooperative Extension

No abstract provided.


Effects Of Concurrent Neuropathologies With Alzheimer Disease Neuropathologic Change On Cognitive Decline: Minimal Impact Of Vascular Brain Injury Compared With Other Combinations, Sarah M Yasuda, Charles Mock, Kathryn Gauthreaux, Kwun C G Chan, C Dirk Keene, Jessica E Culhane, Yen-Chi Chen, Walter Kukull Aug 2026

Effects Of Concurrent Neuropathologies With Alzheimer Disease Neuropathologic Change On Cognitive Decline: Minimal Impact Of Vascular Brain Injury Compared With Other Combinations, Sarah M Yasuda, Charles Mock, Kathryn Gauthreaux, Kwun C G Chan, C Dirk Keene, Jessica E Culhane, Yen-Chi Chen, Walter Kukull

2020-Current year OA Pubs

We examined cognitive changes associated with several neuropathologic entities, alone and in combination. We studied 808 participants from the National Alzheimer's Coordinating Center to assess associations between neuropathologic diagnoses (from autopsy) and neuropsychologic test scores (trajectories over time for 5 domains: overall cognition, episodic memory, attention, language, executive function). Neuropathologies included: Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), vascular brain injury (VBI), and limbic-predominant age-related TDP43 encephalopathy neuropathologic change (LATE-NC). Using linear mixed-effects models, we examined trajectories of cognitive decline for ADNC alone compared to ADNC plus LBD, VBI, or LATE-NC. We also examined differences between observed trajectories …


Validated Crispr/Cas9 Guide Rnas Targeting Neurodevelopmental Genes In The Tunicate Ciona Robusta, Sydney Popsuj, Tenzin Kalsang, Eduardo D. Gigante Aug 2026

Validated Crispr/Cas9 Guide Rnas Targeting Neurodevelopmental Genes In The Tunicate Ciona Robusta, Sydney Popsuj, Tenzin Kalsang, Eduardo D. Gigante

Faculty Articles

The tunicate Ciona robusta provides a powerful and simplified model for dissecting the genetic control of developmental and cell biology. With a larval CNS composed of just over 200 neurons and sensory cells, it has also emerged as a model organism for neurobiology and the development of the nervous system. Although CRISPR/ Cas9-mediated mutagenesis is now routinely used in Ciona as an important technique used to interrogate gene function in diverse biological processes, validated single-guide RNAs (sgRNAs) have yet to be validated for several key neural genes. Here, we report the design and experimental validation of 25 novel sgRNAs targeting …


Black Protection: Black Social Media Competency And Urban, Black Adolescents On Social Media, Taylor A. Williams Aug 2026

Black Protection: Black Social Media Competency And Urban, Black Adolescents On Social Media, Taylor A. Williams

Dissertations

While urban, Black adolescents interact with racial identity content on social media, their identity is primarily shaped through offline experiences and later reflected or reinforced online. Through the concept of Black social media competency (B-SMC), this study examined the relationships between Black urban adolescents’ social media use, exposure to race-related content, and experiences navigating the digital environment. The study used a qualitative design, grounded in the phenomenological and ecological frameworks, with 21 adolescents recruited from two urban, Midwestern schools and programs to participate in semi-structured interviews, and data were analyzed using thematic analysis to identify patterns in how the participants …


The Relationship Between Depression And Cognitive Proficiency Index Across Biological Sex, Angela N. Ferdinardo Aug 2026

The Relationship Between Depression And Cognitive Proficiency Index Across Biological Sex, Angela N. Ferdinardo

Dissertations

Depression is a widely studied mood disorder, and understanding its effect on cognitive functioning has become an important area of research. While research has examined relationships among depression, working memory, and cognitive deficits, limited research has explored depressive symptoms and cognitive proficiency across biological sex. Depression manifests similarly in men and women, though men are more likely to experience irritability, impulsivity, and anger, while women tend to experience sadness, stress, and sleep disturbances (Johns Hopkins Medicine, 2023). Women are also more likely to seek treatment and cope differently than men. This study examined the relationship between depression and cognitive proficiency …


Association Between Stress Mindset, Psychological Symptoms, And Psychosocial Risk In Liver Transplant Patients, Sarah Kay Brill Aug 2026

Association Between Stress Mindset, Psychological Symptoms, And Psychosocial Risk In Liver Transplant Patients, Sarah Kay Brill

Dissertations

Psychosocial functioning is a central component of liver transplant evaluation, yet less is known about how cognitive factors, such as stress mindset, relate to transplant readiness. The present study examined the association between stress mindset and psychosocial risk, as well as its relationship with depressive symptoms, anxiety, and perceived stress among patients undergoing liver transplant evaluation. Patients included 62 adults completing standard pre-transplant assessment measures, including the Stress Mindset Measure–Specific (SMM-S), Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Perceived Stress Scale (PSS). Hierarchical logistic regression analyses indicated that stress mindset was …


Seeing The Unspoken: A Pilot Eye-Tracking Study Of Moral Injury Among Veterans, Eva M. Valdez Aug 2026

Seeing The Unspoken: A Pilot Eye-Tracking Study Of Moral Injury Among Veterans, Eva M. Valdez

Dissertations

This pilot study examined associations between self-reported moral distress, state distress, combat exposure, deployment history, and maximum pupil reactivity among veterans diagnosed with PTSD. Participants viewed neutral and morally relevant images while pupil responses were recorded using eye-tracking technology. Self-report measures included moral distress severity, exposure to potentially morally injurious events, Subjective Units of Distress Scale (SUDS) ratings, total deployments, number of combat deployments, and Combat Exposure Scale scores. Maximum pupil reactivity was calculated by subtracting the mean z-scored maximum pupil response during neutral image presentations from the mean z-scored maximum pupil response during morally relevant image presentations. This variable …


The Legacy Of Trauma: Exploring The Effect Of Generational Stress On Gut Health And Mental Well-Being In Black Women, Jocelynn Jones Aug 2026

The Legacy Of Trauma: Exploring The Effect Of Generational Stress On Gut Health And Mental Well-Being In Black Women, Jocelynn Jones

Dissertations

This dissertation examines how generational trauma and chronic stress may relate to gut health and mood outcomes among Black women. Using a literature review design, this work brings together research on intergenerational trauma, gendered racism, Superwoman Schema, weathering, allostatic load, mood disorders, reproductive health disparities, and the microbiota-gut-brain axis. The central argument is that depression, anxiety, gastrointestinal symptoms, fatigue, reproductive vulnerability, and healthcare mistrust should not be understood as fully separate concerns when they may be shaped by shared stress conditions. The proposed integrated model does not claim that trauma directly causes gut dysbiosis or mood disorders. Instead, it suggests …


Pathways To The Streets: A Proposed Model Examining The Factors Influencing Gang Affiliation And Involvement Among Young Black Men In The United States, Ceauna L. Juarez Aug 2026

Pathways To The Streets: A Proposed Model Examining The Factors Influencing Gang Affiliation And Involvement Among Young Black Men In The United States, Ceauna L. Juarez

Dissertations

This literature review examined gang involvement among young Black men in the United States and explored the factors that contribute to joining gangs and the consequences that may follow. The first chapter provides a brief history of gang involvement in Black communities and introduces Erikson’s development model, self-determination theory, and the minorities’ diminished returns as the three theoretical frameworks. The second chapter discusses common challenges faced by young Black men who are currently involved in gangs or are at risk of joining. The chapter explores issues such as life expectancy after gang involvement, adverse childhood experiences, mental health concerns, and …


The Influence Of Leadership On Leader Retention, Ruiwei Li Aug 2026

The Influence Of Leadership On Leader Retention, Ruiwei Li

Dissertations

Prior research provided limited insight into how mid-to-senior leaders experienced and interpreted leadership in relation to retention. This interpretative phenomenological analysis (IPA) study explored how mid-to-senior leaders in a U.S. retail organization experienced and interpreted upper management leadership in relation to their retention decisions. Five leaders with at least four years of tenure participated in semi-structured, in-depth interviews. Each account was analyzed idiographically before patterns of convergence, variation, and divergence were examined across cases. Findings showed that willingness to remain reflected continued internal growth and meaningful influence, supportive leadership that affirmed personal value while preserving agency, and relational and cultural …


Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai Aug 2026

Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai

Faculty, Staff and Students Publications

Purpose: Magnetic resonance imaging using hyperpolarized (HP) [1-13C]-pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi-quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular metabolism. A validated pharmacokinetic (PK) model for analysis of intracellular pyruvate metabolism is needed to enhance the accuracy of quantitative metrics and clinical translation of metabolic MRI using HP pyruvate.

Methods: A PK model with two physical compartments and two chemical pools was developed to analyze the conversion of labeled pyruvate into lactate in vitro. …


Dupilumab Versus Placebo In Adults And Adolescents With Eosinophilic Gastritis (Degas): A Double-Blind, Placebo-Controlled, Phase 2, Multicentre, Randomised Controlled Trial, Nirmala P Gonsalves, Evan S Dellon, Kara L Kliewer, Tetsuo Shoda, Regina Yearout, Seema S Aceves, Nicoleta C Arva, John A Besse, Julie M Caldwell, Mirna Chehade, Amaziah Coleman, Margaret H Collins, Sara Anvari, Gary W Falk, Sandeep K Gupta, Girish Hiremath, David A Katzka, Paneez Khoury, John Leung, Calies Menard-Katcher, Paul Menard-Katcher, Kathryn A Peterson, Maria A Pletneva, Amanda K Rudman Spergel, Jonathan M Spergel, Tatyana Vaysman, Joshua B Wechsler, Benjamin L Wright, Guang-Yu Yang, Xue Zhang, Meijian Zhou, Ashish Bansal, Bram P Raphael, Amr Radwan, Jennifer Maloney, Antonio Martin, Yamo Deniz, Glenn T Furuta, Lisa J Martin, Marc E Rothenberg Aug 2026

Dupilumab Versus Placebo In Adults And Adolescents With Eosinophilic Gastritis (Degas): A Double-Blind, Placebo-Controlled, Phase 2, Multicentre, Randomised Controlled Trial, Nirmala P Gonsalves, Evan S Dellon, Kara L Kliewer, Tetsuo Shoda, Regina Yearout, Seema S Aceves, Nicoleta C Arva, John A Besse, Julie M Caldwell, Mirna Chehade, Amaziah Coleman, Margaret H Collins, Sara Anvari, Gary W Falk, Sandeep K Gupta, Girish Hiremath, David A Katzka, Paneez Khoury, John Leung, Calies Menard-Katcher, Paul Menard-Katcher, Kathryn A Peterson, Maria A Pletneva, Amanda K Rudman Spergel, Jonathan M Spergel, Tatyana Vaysman, Joshua B Wechsler, Benjamin L Wright, Guang-Yu Yang, Xue Zhang, Meijian Zhou, Ashish Bansal, Bram P Raphael, Amr Radwan, Jennifer Maloney, Antonio Martin, Yamo Deniz, Glenn T Furuta, Lisa J Martin, Marc E Rothenberg

Faculty, Staff and Students Publications

Background: Eosinophilic gastritis currently has no approved treatments and is postulated to be driven by type 2 inflammation. Dupilumab blocks type 2 cytokines IL-4 and IL-13 and has efficacy in multiple diseases characterised by type 2 inflammation, including eosinophilic oesophagitis. We aimed to assess the efficacy and safety of dupilumab in patients with eosinophilic gastritis.

Methods: DEGAS was a proof-of-concept, phase 2, multicentre, randomised controlled trial consisting of a 12-week, double-blind, placebo-controlled period, followed by a 24-week open-label extension period. Patients aged 12-70 years from 11 hospitals in the USA with histologically active eosinophilic gastritis (≥30 eosinophils per high-power field …


Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium Aug 2026

Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium

Faculty, Staff and Students Publications

Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D case subjects, 61,036 control subjects, and up to 50,011 individuals with no diabetes with fasting glucose, fasting insulin, and HbA1c from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Program. We performed single-variant association testing, conditional analysis, fine-mapping, and Bayesian colocalization to …


Piracy, Terrorism, And The Law: Differential Equations In Hostage Situations, Gabriel Hallevy Jul 2026

Piracy, Terrorism, And The Law: Differential Equations In Hostage Situations, Gabriel Hallevy

Journal of Humanistic Mathematics

Pirates have taken the crew of an American ship hostage. They promise to release the hostages only if another pirate who is held in an American prison for commission of piracy crimes against American citizens, is released. Should the U.S. government enter into negotiations with them? Should they send armed forces and risk the hostages? Should they release the prisoner immediately and unconditionally? The article models and analyzes possible policies regarding sensitive situations involving hostages and other related risks using differential equations. The solutions are surprisingly simple, but not necessarily intuitive. Our analysis aims to demonstrate how powerful mathematics is …


Technological Behaviour Of Pellets Containing Dried Green Crop, Christian Furll Jul 2026

Technological Behaviour Of Pellets Containing Dried Green Crop, Christian Furll

IGC Proceedings (1977-2023)

Pelleted dried green crop presents essential advantages compared to chaff and meal as processing forms. Normally, the solidity of the pellets does not exceed the values required by animal feeding. Abrasion resulting from turnover processes is at present too high, particularly for the discharge of bins. Belt conveyors, vibrating conveyors, and bucket elevators are suitable to convey pellets. Storage of pellets over long periods has to be done by respecting prescribed climate conditions. Zones with excessive portion of abraded par­ticles in the storing pile are a preferred cause for self-heating. Slit-type dosing units as well as dosing units equipped with …


Results Of Comparative Investigations Into The Chevving And Ruminating Activities Of The Dairy Cow Fed Dried Forage From Grass And Leguminous Crops, B Piatkowski, S Nagel Jul 2026

Results Of Comparative Investigations Into The Chevving And Ruminating Activities Of The Dairy Cow Fed Dried Forage From Grass And Leguminous Crops, B Piatkowski, S Nagel

IGC Proceedings (1977-2023)

The chewing and ruminating activities were studied of dairy cows fed grass, alfalfa, and straw of different physical forms. An electronic­ally controlled measuring device was applied. When feeding 8 kg of grass hay (32 % crude fibre in dry matter), the ruminating time was 5: 24 and 1 :49 hours (20,712 and 6,982 ruminat­ing movements) for chopped and ground + pelleted forages, respectively. It declined from 1 : 49 to 0: 0 l hours (from 6,929 to 70 move­ments) when hot-air dried alfalfa (23 % crude fibre) was fed in chopped and ground + pelleted forms, respectively. The ruminating time …