Digital Commons Network^™

Neuro-Advocacy: Harmonizing Persuasion With The Operation Of The Brain, Gary Gildin

Faculty Scholarship

The most significant contemporary advances in effective courtroom advocacy will emerge from what on the surface is an unlikely source: neuroscience. Revolutionary advances in technology for the first time allow us to see how the human brain makes decisions. The findings are wholly inconsistent with how the trial process presupposes the finder of fact will perceive and use information delivered by lawyers and witnesses. Consequently, lawyers seeking to persuade jurors (and judges) must reframe their advocacy to align with what we have learned about how the minds of these decision-makers will receive testimony and argument and use these inputs to …

The Serotonin 1b Receptor In Psilocybin’S Therapeutic-Like Mechanisms: From Behavior To Network Reorganization, Sixtine Fleury

Dartmouth College Ph.D Dissertations

Mood disorders represent a substantial and growing global health crisis, with ~10 million adults in the US meeting criteria for a major depressive disorder (MDD). Current first-line treatments such as SSRIs require long-term daily administration and fail a significant proportion of patients, driving renewed interest in rapid-acting alternatives. Psilocybin, a serotonergic psychedelic, shows growing clinical evidence of efficacy in treating depressive and anxiety disorders, often producing therapeutic effects persisting weeks to months following a single dose. Yet, the neural mechanisms underlying these enduring effects remain poorly understood and have been largely attributed to the serotonin 2A receptor (5-HT2AR) based on …

Polymeric Micelle In Drug Delivery And Nanotechnology: Preparation Methods And Multifunctional Application, Abhishek Sanjay Patil, Savita Ullegaddi, Nagesh C, Suma N

Manipal Journal of Medical Sciences

Nanomedicine, an emerging discipline, integrates nanotechnology with pharmaceutical and biomedical science to develop new drugs and imaging compounds with improved efficacy and safety profiles. One of the most important aspects of this field is the creation of new nano-drug delivery systems (NDDS), which harness the power of nanomaterials to bypass such conventional limitations as poor solubility and instability. One form of NDDS, micelles, have been identified as a viable option, providing a safe and effective means of encapsulating hydrophobic natural products. Self-assembling amphiphilic block copolymers, micelles form a core-shell structure that shields the encapsulated drug from degradation while allowing controlled …

Dr. Janice Chism Piano Music Collection - Accession 1744, Janice Chism

Manuscript Collection

The Dr. Janice Chism Piano Music Collection consists of piano sheet music owned and used by Dr. Janice Chism, a distinguished professor of Biology and Anthropology at Winthrop University. The collection reflects Dr. Chism’s personal musical interests and provides insight into popular and classical music performed in domestic and recreational settings during the early to mid-twentieth century.

The collection is composed primarily of individual pieces of piano sheet music dating from approximately 1919 to 1951, with the majority originating in the 1920s, 1930s, and 1940s. Titles include popular show tunes, jazz-influenced standards, patriotic and folk songs, and light classical arrangements. …

Luckett Davis Lecture Notes Collection - Accession 1846, Luckett Vanderford Davis

Manuscript Collection

The Dr. Luckett Davis Lecture Notes Collection documents the teaching and academic work of Luckett Vanderford Davis, Professor of Biology at Winthrop University, where he served from 1964 until his retirement and later held the title of Emeritus Professor of Biology. The collection consists primarily of lecture notes, seminar materials, laboratory manuals, and instructional aids used by Dr. Davis in teaching a wide range of undergraduate biology courses.

The bulk of the collection contains handwritten and typed lecture notes prepared for courses in zoology, genetics, evolution, ecology, and marine biology. These materials document Dr. Davis’s approach to teaching biological sciences …

Immune Suppression And Epigenetic Reprogramming In Epithelial-Mesenchymal Transition, Hanxu Lu

Dartmouth College Ph.D Dissertations

Epithelial-mesenchymal transition (EMT) is increasingly recognized as a dynamic spectrum of cellular programthat contributes to tumor progression, metastasis, and therapeutic resistance. Rather than existing as discrete epithelial or mesenchymal phenotypes, tumor cells undergo intermediate EMT states in which epithelial and mesenchymal features are partially and variably expressed. In this thesis, I studied EMT state heterogeneity through two complementary and integrated dimensions: tumor-immune interactions and the dynamic remodeling of epigenetic programs across the EMT spectrum. Using a clonal EMT model derived from the murine triple-negative 4T1 mammary carcinoma cell line, including epithelial, intermediate, and mesenchymal states that are stably maintained in …

Organizational Executives’ Perspectives On Cultural Humility And Diversity, Lynette Piggee-Pinero

University of the Pacific Theses and Dissertations

The purpose of this action-oriented dissertation was to understand how executives perceive their own cultural humility and how their perceptions impact diversity promotion in the workplace. This study used action research to examine the perspectives of executives on their own cultural humility and how cultural humility promotes diversity. This study included data collected from interviews with eight executives. Findings from the study revealed that executives perceived their own cultural humility as evident in a commitment to learning about others, their ability to suspend their own biases, and their commitment to ongoing learning. The findings were also that executives expressed connections …

What Makes A Family: Steepparent's Experiences Supporting Children With Autism In School Systems, Veronica Barrera

University of the Pacific Theses and Dissertations

This qualitative multiple case study explored the lived experiences of stepparents of children with autism spectrum disorder, examining how they navigate their roles within school and family systems during early elementary years (kindergarten through second grade). Despite the increasing prevalence of blended families, stepparent perspectives remain largely absent from research. Stepparents often occupy ambiguous legal and social positions that limit their access to educational information and participation in IEP meetings and school decision-making. Two stepparents of children with Level 1 autism participated in semi-structured interviews. Data were analyzed using inductive coding and thematic analysis, with narrative restorying to preserve participants’ …

Detection And Quantification Of Spreading Depolarization In Drosophila Melanogaster Using High-Throughput, Wide-Field Brain Imaging, Wolfgang Stein, Allison L. Harris

Faculty publications – Physics

Spreading depolarization (SD) is a ubiquitous neural phenomenon implicated in mammalian neurological disorders including cerebral ischemia, brain death, stroke, brain injury, and migraine, as well as in insect chill coma. During SD, a breakdown of ion homeostasis and a slowly spreading wave of neural depolarization leads to processing deficits, such as sensory disturbances and paralysis. Our protocols introduce high-throughput techniques using wide-field fluorescence brain imaging in Drosophila melanogaster larvae and adults to detect and quantify the spatial and temporal dynamics of SD and its initiation points. Two SD initiation techniques, rapid cooling and pharmacological manipulation, are detailed. The larval protocols …

Spectroscopic And Structural Characterization Of Unexpected Porphyrinoid Byproducts Resulting From The Reaction Of A Cyclopentadiene Trialdehyde With N-Alkyltripyrranes, Kimberly Le, Gregory M. Ferrence, Timothy D. Lash

Faculty Publications – Chemistry

Acid-catalyzed condensation of N-alkyltripyrranes with a cyclopentadiene trialdehyde, followed by oxidation with aqueous ferric chloride solutions, gave unusual tripyrrolic byproducts in addition to previously reported carbaporphyrins and oxycarbaporphyrins. These stable nonaromatic structures incorporate aldehyde substituents, macrocyclic ketones, two conjugated pyrrole units, and a pyrrolo[1,2-a]pyrrole moiety. The NMR and UV-vis data were consistent with a nonaromatic system, and single-crystal X-ray diffraction confirmed that these structures are highly distorted. Structural characterization of a related aromatic carbaporphyrin triketone was also accomplished.

A Note On The Novel Passive Sampling In Environmental Dna (Edna) Collection Technique To Detect Yellow Mud Turtle (Kinosternon Flavescens): Field And Laboratory Approaches In Turtle Edna, Sakib Tahmid Rishan, Richard J. Kline, Md. Saydur Rahman

School of Integrative Biological & Chemical Sciences Faculty Publications

Environmental DNA (eDNA) is a powerful and sensitive method for monitoring aquatic and terrestrial organisms, offering insights into their distribution. Usually, eDNA is collected using a filter membrane through water filtration. However, the passive eDNA method can simplify sampling and broaden its scope, offering new insights for ecological surveillance. This study examined the efficacy of six different membrane filters in detecting the yellow mud turtle (Kinosternon flavescens) through a novel passive eDNA method. After being immersed in water for 12 h, only the mixed cellulose ester (MCE) membrane filter consistently demonstrated specific polymerase chain reaction (PCR) amplification using …

The Periodical 2025-2026, Southern Adventist University

the Periodical – Chemistry Department Newsletter

Vol. 13, Issue 1 of the Periodical features an article on new faculty member, Sarah Pak, chemistry graduates, and several Meet the Faculty highlights.

Stem Identities Of Iowa State University's Biological And Biomanufacturing Systems Technology Students, Levi Nettleton

Dissertations and Theses @ UNI

STEM identity plays a crucial role in students' pursuit and persistence into the STEM field. Iowa State University's Biological and Biomanufacturing Systems Technology (BBST) undergraduate program, developed in alignment with the goals of Chemurgy 2.0, prepares students for careers in the growing STEM workforce. The purpose of this study is to examine how participation in the Biological and Biomanufacturing Systems Technology program influences undergraduate students' STEM identity and how students within the program perceive themselves within the scope of STEM. Specifically, the study investigates students' perceptions of their STEM identity across the four components of STEM identity: recognition, performance and …

Liver X Receptor Α (Lxrα) Regulates 5Β-Reductase (Akr1d1) Expression In Avian Embryos: Implications For Yolk Steroid Metabolism, Ryan T. Paitz, Sara E. Waters, Delaney K. Reynolds, Emily M. Drew, Emily P. Harders

Faculty Publications – Biological Sciences

Steroid-mediated maternal effects are well-studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure. The 5β-reduction of steroids by the enzyme 5β-reductase (AKR1D1) has been identified as a pathway through which yolk progesterone, testosterone, and corticosterone are all metabolized early in avian development. We set out to characterize the mechanism through which AKR1D1 expression is regulated in chickens (Gallus gallus) during embryonic development. We found …

A Phenomenological Analysis Of Sense Of Belonging Among Community College Educators, Muhammad Owais Aziz

EVMS School of Health Professions Theses & Dissertations

This phenomenological study explored the complex phenomenon of sense of belonging (SB) among diverse health professions educators (HPEs) and non-health professions educators (non-HPEs) at a Canadian community college. SB, as a dynamic construct shaped by an individual's perception of being valued and respected, is influenced by personal preferences and by complex interactions with the individual's surroundings. To better understand SB and foster a more inclusive environment for diverse educators, it is necessary to investigate SB among these educators. This qualitative study used eleven semi-structured interviews and seven steps of data analysis. The results of this study can inform strategies, policies, …

The Impact Of Synchronous And Asynchronous Preference On The Performance Of Distance Learning Students, Christopher A. Wilson

Electronic Theses and Dissertations

Distance learning is a growing part of education. The transition to distance learning was underway at higher education institutions, but the COVID-19 pandemic forced institutions of all types to rapidly transition to distance learning. The technology that was adapted during this emergency distance learning remained in the classroom once normal instruction resumed. This quantitative study examined two aspects of distance learning technology in education. The study examined student preference for either synchronous or asynchronous instruction through the framework of expectancy theory. Students who were more familiar with the course material were hypothesized to have a higher expectation of success and …

Assistant Principals’ Perspectives And Experiences Concerning Their Influence As Instructional Leaders On Student Achievement In Title I Schools, Courtney J. Charles

Electronic Theses and Dissertations

Abstract

This qualitative descriptive study explored the perspectives and experiences of assistant principals in Title I schools in the context of their instructional leadership responsibilities. The study examined the relationship between assistant principals as instructional leaders in Title I schools and student achievement by addressing research questions related to curriculum implementation, data-driven decisions, school culture, instructional support, and professional development. Moreover, this study used purposeful sampling to select 13 assistant principals from Title I schools, and data were collected through semistructured interviews and analyzed using thematic analysis. Marzano’s focused school leader evaluation model served as the framework for interview questions. …