Digital Commons Network^™

Cgrp Expression And Signaling Sensitization In A Mouse Model Of Chronic Oxaliplatin-Induced Peripheral Neuropathy, Junwei Du, Leland C Sudlow, Margaret H Johnson, Kanishk Satish, Abraham Villagomez, Hongzhen Hu, Mikhail Y Berezin

2020-Current year OA Pubs

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and dose-limiting side effect of oxaliplatin treatment, yet its molecular mechanisms remain incompletely understood. Calcitonin gene-related peptide alpha (CGRPα, encoded by

Metal–Organic Frameworks : Opportunities And Challenges In Nutrient Recovery, Suchana Amnuaychaichana, Chi-Wang Li, Pongsak (Lek) Noophan, Sumeth Wongkiew

Applied Environmental Research

Nutrient recovery from waste streams is a critical strategy for promoting sustainable agriculture and mitigating environmental degradation. Essential nutrients commonly present in organic waste and wastewater, such as nitrogen and phosphorus, can be reclaimed and reintegrated into agricultural systems. Metal‒organic frameworks (MOFs), which are composed of metal clusters coordinated with organic ligands, have emerged as promising materials for adsorption and have the potential for nutrient recovery and pollutant removal because of their high porosity, large surface area, and tunable physicochemical properties. These attributes enable MOFs to serve in diverse applications, including heavy metal adsorption, organic pollutant degradation, and nutrient transformations. …

Psychological And Clinical Risk Factors For Substance Use In People With And Without Hiv, Joanna M Hobson, Shameka L Cody, Shannon R Gilstrap, Michael A Owens, Myles D Moody, Dyan M White-Gilliam, Stephen Justin Thomas, Emily J Bartley, Burel R Goodin

2020-Current year OA Pubs

BackgroundDespite growing concerns, limited research has demonstrated how psychological factors influence substance use in people with HIV (PWH). Therefore, we examined the association between heightened vigilance and substance use outcomes in people with (PWH) and without HIV (PWoH), while accounting for key risk factors.MethodsParticipants (n = 138) were recruited from an HIV clinic and the surrounding community, completing a urine drug screener (UDS) and questionnaires.ResultsPWH reported greater insomnia (

Perception Of Dementia Risk Among Black Adults: An Ecological Analysis Of Causal Loop Diagrams With A Structural And Social Determinant Of Health Composite Index, Jean-Francois Trani, Ramkrishna K Singh, Alexis Ib Walker, Semere Bekena, Yiqi Zhu, Ganesh M Babulal, Robbie Hart

2020-Current year OA Pubs

INTRODUCTION: To investigate drivers of dementia risk disparities among older Black Americans using a community-based system dynamics (CBSD) approach.

METHODS: Over 18 months, 234 participants created 36 causal loop diagrams (CLDs) on dementia risk. An ecological analysis compared structural differences across groups based on scores on a structural and social determinants of health composite index (S/SDOH-CI).

RESULTS: Groups in the highest SDOH-CI quantile were more likely to identify key protective pathways linking mental health, substance use, exercise, medication, and community support to reduce dementia risk. In contrast, fewer than 25% of low-SDOH-CI groups identified these connections, and under 15% recognized …

Novel Insights Into Early Alzheimer's Disease: Quantitative Gradient Recalled Echo Mri Reveals Preatrophic Neuronal And Myelin Injury Concurrent With Emerging Amyloid Pathology, Satya V V N Kothapalli, Tammie L S Benzinger, Randall J Bateman, Melody Li, Cihat Eldeniz, John C Morris, Dmitriy A Yablonskiy

2020-Current year OA Pubs

BACKGROUND: Brain amyloid accumulation is considered an early sign of Alzheimer's disease (AD) pathology, appearing decades before manifestation of clinical symptoms. However, very little is known about neurodegeneration during this early AD stage. Herein we use quantitative gradient recalled echo (qGRE) magnetic resonance imaging (MRI) to reveal preatrophic microstructural neuronal and myelin damage concurrent with amyloid pathology.

METHODS: qGRE MRI and positron emission tomography (PET) amyloid [

RESULTS: qGRE detected significantly lower gray matter neuronal density and white matter myelination in the group of participants with amyloid level below the conventional amyloid-positive threshold (mean cortical standardized uptake value ratio of …

The Association Between Major Depressive Disorder, Plasma Biomarkers Of Alzheimer's Disease, And Mild Behavioral Impairment Among Older Adults, Yiqi Zhu, Jean-Francois Trani, Ramkrishna K Singh, Semere Bekena, Jonathan Williams, Eric J Lenze, Ganesh M Babulal

2020-Current year OA Pubs

INTRODUCTION: Plasma biomarkers and mild behavioral impairment (MBI) are associated with dementia risk, but their relationships with major depressive disorder (MDD) are understudied. This study aimed to examine associations between plasma biomarkers of Alzheimer's disease (AD) and MBI among older adults with and without MDD.

METHODS: Older adults aged ≥65 were recruited from longitudinal studies of depression and AD (

RESULTS: Older adults with MDD were more likely to endorse MBI. After adjustment, Aβ42/Aβ40 and p-tau217/np-tau217 positivity were associated with MBI among those with MDD but not among those without.

DISCUSSION: Neuropsychatric symptoms (NPS) and biomarkers are AD risk factors. …

The Impact Of Congenital Heart Disease On The Timing Of Alzheimer's Disease In Down Syndrome, Julianne G Clina, Beau Ances, Et Al.

2020-Current year OA Pubs

INTRODUCTION: The incidence of Alzheimer's disease (AD) in Down syndrome (DS) exceeds 90%. Approximately 50% of people with DS have congenital heart disease (CHD). Having CHD increases risk for early-onset AD in populations without DS, but it is unclear if CHD influences AD in DS.

METHODS: Data from the Alzheimer Biomarker Consortium-Down Syndrome (ABC-DS) were used. Participants with CHD (

RESULTS: People with CHD scored lower for visuospatial ability (

DISCUSSION: Presence of CHD may influence AD progression in DS.

HIGHLIGHTS: In adults with Down syndrome (DS), those with congenital heart disease (CHD) had higher amyloid beta and reached the …

Alzheimer's Disease Stage 1 And 2: Biology, Diagnostics, And Treatment, Suzanne E. Schindler, Sarah M. Hartz, Et Al.

2020-Current year OA Pubs

No abstract provided.

Eligibility For Anti-Amyloid Treatment In A Multiethnic Community-Based Study, Lydia Trudel, Joseph Therriault, Arthur C Macedo, Karin L Meeker, Meredith N Braskie, Arthur W Toga, Serge Gauthier, Paolo Vitali, Suzanne E Schindler, Sid E O'Bryant, Pedro Rosa-Neto

2020-Current year OA Pubs

INTRODUCTION: The approval of anti-amyloid monoclonal antibodies (mAbs), including lecanemab and donanemab, represents a significant advance in disease-modifying therapies (DMTs) for early Alzheimer's disease (AD). While appropriate use recommendations (AURs) have been established to guide clinical decision-making, the proportion of individuals with cognitive impairment in real-world, multiethnic populations meeting eligibility criteria remains unknown, as do potential differences in treatment-related risks across ethnic groups.

METHODS: We included 513 cognitively impaired individuals from the Health and Aging Brain Study-Health Disparities study, a multiethnic community-based cohort. Eligibility for lecanemab and donanemab was determined using published AUR criteria. Counts of amyloid-related imaging abnormalities were …

Rationale And Trial Design Of Ribolaris: A Phase Ii Trial Of Neoadjuvant And Adjuvant Ribociclib Plus Endocrine Therapy For Clinically High-Risk Hr+/Her2-Negative Breast Cancer, Paul Cottu, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

BACKGROUND: Despite advances in endocrine therapy, patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC) remain at risk of recurrence (ROR). Chemotherapy is often used in high-risk cases, but not all patients benefit.

OBJECTIVES: To evaluate whether chemotherapy can be safely omitted in patients with stage II, grade 2/3 HR+/HER2- eBC who convert to low genomic risk (ROR-low) following neoadjuvant ribociclib plus letrozole.

METHODS: RIBOLARIS (NCT05296746) is an open-label, multicenter phase II trial in patients with stage II, grade 2 or 3, HR+/HER2- eBC defined as high risk based on a Ki-67 index ⩾20% …

Establishing Demographic-Based Normative Values For Neurofilament Light Chain And Glial Fibrillary Acidic Protein In Serum And Plasma Samples, Tyler L Borko, Salim Chahin, Et Al.

2020-Current year OA Pubs

BACKGROUND: Interpretation of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) levels in blood requires reference ranges from healthy cohorts, accounting for demographic features.

OBJECTIVE: To compare serum and plasma NfL and GFAP in healthy individuals, accounting for age, sex, and body mass index (BMI).

METHODS: Adolescents through older adults were recruited at Colorado community events and a senior clinic. A neurologist reviewed self-reported medical histories. Paired serum and EDTA plasma samples were assayed using the Quanterix SR-X Simoa Neuro 4-Plex. Log-linear models estimated percent change per year of age, per BMI unit, and sex ratios. GFAP used …

Concordance Of Fluorescence In Situ Hybridization, Whole-Exome Sequencing, And Chromosomal Microarray For Evaluating High-Risk Molecular Features In Meningiomas, Brenndan Crumley, Emilie Russler-Germain, Sonika Dahiya

2020-Current year OA Pubs

BACKGROUND: Meningiomas are the most common primary intracranial tumors, classified into three WHO grades based on histologic and/or molecular criteria. cIMPACT-NOW Update 8 underscores the increasing importance of molecular testing in grading and risk stratification, noting that morphologically WHO grade 1 tumors with concurrent 1p and 22q losses demonstrate clinical behavior comparable to WHO grade 2 meningiomas. This study aimed to assess the concordance of fluorescence in situ hybridization (FISH), chromosomal microarray analysis (CMA), and whole-exome sequencing (WES) in defining the molecular risk profile of meningiomas.

METHODS: A total of 113 meningiomas were analyzed by WHO grade to assess the …

Seasonal Variations In Co2 Emission From Poultry Manure-Amended Soils In Two Contrasting Tropical Agroecosystems, Gladys M. Akande, Adebayo J. Adeyemo, Chidozie J. Oraegbunam, Iduh J.J. Otene, Ezekiel C. Are, Babatunde S. Ewulo, Chioma M. Ahukaemere, Samuel O. Kolawole, Sunday E. Obalum

Applied Environmental Research

The soil remains the largest carbon sink, the capacity of which varies spatiotemporally and with anthropogenic activities, with implications for carbon dioxide (CO2) emissions and associated global warming. Despite the increasing popularity of organic amendments in the ecologically and anthropoculturally diverse farming systems of tropical Africa, manure-induced CO2 emissions in this region with high soil-carbon-sequestration potential are poorly documented. This study assessed seasonal CO2 emissions from poultry manure-amended sandy-clay-loam and sandy-loam soils in the Rainforest-Savannah and Southern Guinea Savannah zones, respectively, of Nigeria. Following manure application at 3 rates (0, 10, and 15 t ha-1), soil samples were collected during …

Activated Carbon Prepared From Residual Eucalyptus Wood For The Removal Of Methyl Orange: Equilibrium, Kinetics, Thermodynamics, And Desorption, Mathin Jaikua, Phuthidhorn Thanaphu, Sunisa Ungwiwatkul, Jakkrawut Maitip, Kanyarak Prasertboonyai

Applied Environmental Research

This research utilizes activated carbon derived from residual Eucalyptus wood (EW) for the removal of methyl orange (MO). The residual Eucalyptus wood-based activated carbon (EWAC) was produced through carbonization at 400 °C (EWC) followed by activation with a mass ratio of H3PO4 to EWC of 1:3, which was conducted at 800 °C for 1 h. The characterization of the EWAC involved various analytical techniques, including FTIR, XRD, BET, and CHN analysis. The adsorption parameters, such as pH (range: 3–8), adsorbent dose (range: 0.01–0.5 g per 50 mL of MO solution), contact time (range: 5–720 min), initial MO concentration (range: 5–600 …

Blue Carbon Stock Assessment And Climate Resilience Potential Of Mangrove Forest In Hung Thang Commune, Vietnam, Hla Phong Ko, Pham Hong Tinh, Nguyen Thuy Duong

Applied Environmental Research

Mangrove forests are vital blue carbon sinks that contribute to climate change mitigation and coastal resilience. This study assessed the carbon stock and spatial‒temporal dynamics of a mangrove forest in Hung Thang commune, Hai Phong Province, Vietnam, via a combination of field measurements, soil organic carbon (SOC) analysis, and normalized difference vegetation index (NDVI)-based remote sensing models. The results revealed that mangroves in the Hung Thang community store an average of 87.42 tC ha-1, with SOC accounting for approximately 19% of the total carbon. A generalized additive model (GAM) analysis revealed a consistent increase in carbon stocks between 1996 and …

Bioremediation Potential Of Indigenous Stutzerimonas Stutzeri 08tbb Isolated From Mercury-Contaminated Gold Mining Sites In Indonesia, Uun Rohmawati, Juanita Hibatullah, Achmad Rodiansyah, Yunita Messe, Dwi Nur Aini Fajriah

Applied Environmental Research

Artisanal and small-scale gold mining (ASGM) widely uses mercury (Hg) in the amalgamation process, and the resulting waste is often discharged directly into the environment, posing serious risks to ecosystems and human health because of the high toxicity of Hg. This study aimed to isolate and screen indigenous Hg-tolerant bacteria from contaminated gold mining sites in Indonesia; characterize the most effective isolate using morphological, biochemical, and molecular approaches; evaluate Hg(II) degradation performance using ICP‒OES, FTIR, and SEM analyses; and identify key metabolites involved in Hg detoxification through untargeted LC–HRMS metabolomics. A total of 51 bacterial isolates were obtained from Hg-contaminated …

Ammonium Adsorption From Aqueous Solutions Using Mnfe2o4-Functionalized Coffee Husk Biochar Nanocomposites : An Evaluation Of Hno3 And Naoh Activation, Thuy-Tien Do, Huu-Tap Van, Thi-Minh-Thu Nguyen

Applied Environmental Research

This research investigated the development of MnFe2O4-based composite adsorbents (MFO@CFA and MFO@CFB) by activating coffee husk-derived biochar with HNO3 and NaOH, followed by synthesis through coprecipitation and hydrothermal techniques. The structural and chemical properties of the nanocomposites were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. Batch adsorption experiments were used to assess ammonium removal efficiency across a range of conditions: solution pH (3–8), contact time (5–120 min), adsorbent dosage (0.2–3 g L-1), and initial ammonium concentration (10–60 mg L-1). The findings indicated that compared with MFO@CFB, which was synthesized from NaOH-activated biochar, MFO@ CFA, derived …

Assessing Forest Fragmentation And Edge Expansion In Nan Province, Thailand, Using Landsat Data (2014–2022), Kasidit Rison, Marut Fuangarworn, Chatchawan Chaisuekul

Applied Environmental Research

The increasing pressure from land-use change and agricultural expansion in Nan Province, northern Thailand, has accelerated forest fragmentation and reduced the ecosystem service value (ESV) of the landscape. This study aims to: assess land use and forest fragmentation change in Nan Province between 2014 and 2022, and evaluate the impact of land use change on ESV. Landsat 8 OLI satellite imagery from 2014 and 2022 was used to classify land cover into five types: forest, agriculture, settlements, exposed soil, and others. Forest fragmentation was evaluated using landscape metrics such as patch number, mean patch size, edge length, and core area. …

Performance And Mechanisms Of Activated Natural Coagulants For Efficient Microcystis Removal Via Coagulation–Flocculation In Thailand, Apiradee Sukmilin, Peangtawan Phonmat, Ratcha Chaichana

Applied Environmental Research

Thailand produces fruit peels and seeds rich in natural polymers, which can serve as eco-friendly coagulants to control algal blooms. In this study, banana peel (Musa spp.), orange peel (Citrus sinensis), basil seed (Ocimum basilicum) mucilage, and chia seed (Salvia hispanica) mucilage were used. These activated natural coagulants with aluminum were compared with nonactivated and commercial coagulants (ferric sulfate, ferrous sulfate, and polyaluminum chloride) for Microcystis removal. Phytochemical composition analysis, Fourier transform infrared (FTIR) spectroscopy, and oxidation–reduction potential (ORP) analysis were conducted. The results revealed that banana and orange peels contain phenolic compounds, …

Evaluating Sediment Control Strategies Using Swat Based Bmp Assessment In A Tropical Highland Watershed, Northern Thailand, ฺBanchongsak Faksomboon, Wilailak Suanmali

Applied Environmental Research

Soil erosion remains a critical environmental challenge in the tropical highland watersheds of Southeast Asia, where steep terrain, intense monsoonal rainfall, and intensive land use interact to accelerate sediment generation and downstream degradation. This study aims to quantify spatial patterns of sediment yield and to systematically evaluate the effectiveness of individual and combined best management practices (BMPs) at both the watershed and subwatershed (SWW) scales using the Soil and Water Assessment Tool (SWAT) in a tropical highland watershed in northern Thailand. Baseline simulations reveal pronounced spatial heterogeneity in erosion severity, with substantial portions of the watershed exhibiting moderate to extreme …

Application Of Diatom Indices To Monitor Environmental Shifts In The Downstream Tuntang River, Central Java, Mirza Hanif Al Falah, Tri Retnaningsih Soeprobowati, Hadiyanto -, Muhammad Isnaini Ibnu Sabil, Marta Wojewódka-Przybył, Łukasz Kruszewski, Paweł Rydelek

Applied Environmental Research

Diatoms are widely recognized as sensitive bioindicators for reconstructing past water quality and ecological changes in aquatic ecosystems. In this study, multiple diatom-based indices were applied to sediment cores collected from three downstream stations of the Tuntang River, Central Java, to infer long-term environmental change in a tropical river system. A total of 38 sediment subsamples were analyzed, with dominant taxa including Fragilaria crotonensis (2.4–18.6%), Nitzschia palea (3.1–22.4%), and Aulacoseira granulata (2.0–15.8%), indicating sustained nutrient enrichment. Diatom indices consistently classified conditions as mesotrophic to eutrophic throughout the sediment profiles. The occurrence of the marine diatom Cylindrotheca closterium (up to 6.3%) …

Sustainable Approach For The Removal Of Cu(Ii) From Aqueous Solutions Using Lotus Seedpod-Alginate Composite Biosorbents, Lan Tran-Nguyen, Hue Tran Nguyen-Le, Hong T Hi Anh Nguyen, Tran Nguyen-Phuong-Dung, Ly Kim-Phung, Huynh Quoc-Khanh, Nguyen Minh-Nhut, Phuong Lan Tran-Nguyen

Applied Environmental Research

Turning waste or agricultural byproducts into valuable products has recently become a concern of scientists. In this study, the facile and cost-effective synthesis of a biocomposite derived from lotus seedpod (LS) and alginate (AG) was further applied for Cu2+ ion uptake from aqueous solutions. SEM images revealed the layered structures of the composites, which were thin and irregularly stacked sheets of a complex 3D network. The abundant functional groups on the surface of the LS-based material and its negative zeta potential value of -37.50 mV also facilitated efficient Cu2+ removal. Adsorption results revealed a Cu2+ adsorption efficiency (AE) and experimental …

Tree Composition And Carbon Sequestration Potential Of A University Campus In Bangkok, Thailand, Chaiwat Boonpeng, Pawanrat Butrid Butrid, Marisa Pischom, Satatip Noikrad

Applied Environmental Research

Trees play important roles in atmospheric carbon dioxide (CO2) absorption and climate change mitigation. The objective of this study was to assess tree characteristics and carbon sequestration potential at Ramkhamhaeng University (Hua Mak Campus), Bangkok, Thailand. Tree attributes, including species composition, abundance, diameter at breast height (DBH), and tree height, were recorded. Tree biomass, carbon storage, and CO2 sequestration were estimated using appropriate allometric equations. A total of 2,149 trees were recorded in the study area, corresponding to a tree density of 45.8 trees ha-1. The tree community was dominated by the palm family (Arecaceae), while Terminalia ivorensis was the …

Initial Screening Of Halophilic Plastic-Degrading Bacteria From Mangrove Water And Sediment In Pekalongan, Indonesia, Novia Safinatunnajah, Muhammad Zainuri, Aris Ismanto, Tony Hadibarata, Kunarso -, Sugeng Widada, Hermin Pancasakti Kusumaningrum, Candra Wahyuningsih

Applied Environmental Research

Microplastic pollution in tropical mangrove ecosystems represents an increasing environmental concern, particularly in coastal regions such as Pekalongan, Indonesia, where industrial and residential activities contribute substantially to plastic waste. This study aimed to isolate and preliminarily screen halophilic bacteria from mangrove sediments and seawater collected from a plastic-impacted coastal area. Using mineral salt medium (MSM) supplemented with polyethylene glycol (PEG), six bacterial strains were obtained and evaluated for their potential to interact with polyethylene (PE) and polypropylene (PP) on the basis of gravimetric weight loss measurements. Among the isolates, Halomonas Cupida A1, Marinobacter nauticus A6.3, and Marinobacter nauticus SD5.2 exhibited …

Effects Of The Psb-To-Ow Ratio And Light Intensity On Biogas Composition During Phototrophic-Assisted Anaerobic Fermentation Of Organic Waste, Kridsana Jirasansawat, Sirilak Prasertkulsak, Nitiwist Teangthai

Applied Environmental Research

The integration of phototrophic processes into anaerobic fermentation offers a promising strategy for improving biogas quality; however, the combined effects of the photosynthetic bacteria-to-organic waste (PSB-to-OW) ratio and light intensity remain unclear. In this study, the photosynthetic bacteria (PSB)-assisted anaerobic fermentation of municipal organic waste under varying PSB-to-OW ratios and light intensities was evaluated. An optimal PSB-to-OW ratio of 1:2 resulted in significantly higher CH4 concentrations and lower CO2 and H2S concentrations than the other tested ratios did (p < 0.05). At this ratio, moderate illumination (2000 lx) resulted in the highest CH4 concentration (68.2 ± 0.3%), compared with 1000 lx (61.5 ± 0.4%) and 4000 lx (63.1 ± 0.5%). Under illumination, the CO2 and H2S concentrations were lower than those under dark conditions, indicating a more favorable biogas composition. Kinetic analysis indicated that CO2 and H2S exhibited apparent first-order behavior under illumination, with the highest rates occurring at 2000 lx (kH2S = 0.093 day-1; kCO2 = 0.059 day-1), suggesting light-dependent transformation processes. Metagenomic analysis revealed a microbial community dominated by sulfide-oxidizing (Chlorobium sp.), photoheterotrophic (Rhodopseudomonas sp.), and syntrophic bacteria, supporting coupled carbon conversion and sulfur transformation. Overall, optimization of the …