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2026

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Syllabus: Guttman Psyc101: Introduction To Psychology, Natalia Lara Gonzalez Jan 2026

Syllabus: Guttman Psyc101: Introduction To Psychology, Natalia Lara Gonzalez

Open Educational Resources

The present syllabus includes materials to be used for an introduction to psychology class. The topics range from basic cognitive, behavioral and developmental psychology to social sciences and nature vs. nurture debates. The syllabus also includes an abnormal psychology open access textbook where students can access details on mental health conditions which they present on at the end of the semester.


Disconsents, Daryl J. Levinson, David E. Pozen Jan 2026

Disconsents, Daryl J. Levinson, David E. Pozen

Faculty Scholarship

Consent is an indispensable standard and organizing principle in any liberal legal order that prizes self-directed autonomy, self-identified preferences, and collective agreement. Yet consent’s capacity to advance those values has become increasingly uncertain in a society beset by power imbalances, information asymmetries, and multiple forms of polarization. In this Article, we document how the rise of neoliberalism has led to greater reliance on consent throughout U.S. law, while at the same time leading to greater doubts about its moral efficacy and empirical feasibility. Connecting and generalizing pathologies of consent-based regulation that have been identified within myriad domains, the Article identifies …


Beyond The Brotherhood: Exploring Communal Leadership In Masculinity Contest Cultures, Scott A. Metzler Jan 2026

Beyond The Brotherhood: Exploring Communal Leadership In Masculinity Contest Cultures, Scott A. Metzler

Antioch University Dissertations & Theses

This phenomenological study explores the lived experiences of formal and informal leaders who exercise communal leadership, characterized by collaboration, inclusion, and relational focus, within the masculinity contest cultures of law enforcement and the fire service, where strength, competition, and hierarchical leadership often rule the day. Through in-depth qualitative interviews with 19 participants across the United States, this research investigates how and why leaders choose to challenge organizational norms, how they perceive the effects of their decisions on themselves and others, and how they navigate the tensions and contradictions between communal leadership and hypermasculine cultural expectations. The findings reveal that leaders …


Diagnosing The Discourse: How The Academy Of Breastfeeding Medicine Constructs And Constrains Treatment Of Tethered Oral Tissues, Mary E. Miller Jan 2026

Diagnosing The Discourse: How The Academy Of Breastfeeding Medicine Constructs And Constrains Treatment Of Tethered Oral Tissues, Mary E. Miller

Antioch University Dissertations & Theses

While breastfeeding is recognized as fundamental to global public health, oral restrictions that can affect infant latch, milk transfer, and feeding efficiency warrant further examination within policy frameworks. This dissertation proposes an expanded conceptualization of tethered oral tissues (TOTs) that encompasses not only anatomical frenal restrictions but also fascial tensions, neuromuscular limitations, and other conditions restricting orofacial function that may be congenital or acquired. The purpose of this study was to critically examine how this clinical guidance document shapes understandings and responses to TOTs. Using Carol Bacchi’s “What’s the Problem Represented to Be?” approach, a critical discourse analysis of the …


Feeling Seen By Being Heard: A Constructivist Critical Incident Study Of The Listening Experiences Of Ciswomen Of Color For The Development Of An Inclusive Listening Praxis For Leaders, Christina Zhong-Wen Chang Jan 2026

Feeling Seen By Being Heard: A Constructivist Critical Incident Study Of The Listening Experiences Of Ciswomen Of Color For The Development Of An Inclusive Listening Praxis For Leaders, Christina Zhong-Wen Chang

Antioch University Dissertations & Theses

This study examines how listening shapes inclusive workplaces by exploring the listening experiences of 23 professional cisgender women of color working in predominantly white institutional spaces. Although listening is a fundamental part of communication, it is frequently undervalued and overlooked in leadership literature. Using the constructivist critical incident technique (CCIT) methodology, the research analyzed 88 significant moments when participants felt distinctly heard or unheard by leaders. Findings reveal that listening operated as a relational practice signaling respect, affirmation of voice, and anchoring leadership in accountability, while enabling leaders to engage perspectives beyond their own. Four listening types emerged: Listening Withheld, …


A Content Analysis Of Black Women's Race And Gender Depiction In American History Textbooks, Le'marqunita De'sharay Lowe Jan 2026

A Content Analysis Of Black Women's Race And Gender Depiction In American History Textbooks, Le'marqunita De'sharay Lowe

Antioch University Dissertations & Theses

Using a race and gender analytical lens, this research study examined how Black women were depicted in four secondary Advanced Placement Pearson’s history textbooks. Content analysis was the methodology to collect data from Pearson’s Advanced Placement history textbooks. Captions and images were analyzed to observe the patterns and themes that displayed the intersection between Black women's race and gender depiction. The interdisciplinary fields of history and education allowed an in-depth analysis of race and gender to be conducted throughout this research study. Two research questions were answered throughout this study. What do captions and images teach about the race and …


Octavia E. Butler's Healing Heroines: An Exploration Of Black Girl Magic In The Patternist Series, Monique Skinner Jan 2026

Octavia E. Butler's Healing Heroines: An Exploration Of Black Girl Magic In The Patternist Series, Monique Skinner

Antioch University Dissertations & Theses

This study explores the concept of healing as Black Girl Magic in the five novels that make up Octavia E. Butler’s Patternist series. Through textual analysis backed in Afrofuturist theory the study answers the questions: How does Butler depict Black women as healers in the Patternist series? and What is her vision of Black women in the Afrofuture? On a deeper level, the study uses character analysis to examine the literary trope of the Black woman healer and how her magical power translates as literal Black Girl Magic. Through a journey of speculative literary discovery, we uncover the archetypes of …


Weaving Leadership: A Participatory Narrative Inquiry Into Alaska Native Women’S' Relational And Intersectional Leadership, Aleesha Ikayuk Towns-Bain Jan 2026

Weaving Leadership: A Participatory Narrative Inquiry Into Alaska Native Women’S' Relational And Intersectional Leadership, Aleesha Ikayuk Towns-Bain

Antioch University Dissertations & Theses

Alaska Native women have long supported their families, Tribes, and communities through leadership that is relational, adaptive, and rooted in Indigenous cultural values. In recent years, Alaska Native women have assumed significant leadership roles within a diverse range of Western sectors—including government, business, higher education, and nonprofits—while maintaining roles as critical culture holders and community builders. Despite their contributions, the leadership experiences of these women are poorly understood in both leadership practice and scholarship. The purpose of this research project was to explore how Alaska Native women make meaning of their leadership experiences through Indigenous relational values and at the …


She Leads: A Phenomenological Study Of Women's Leadership Experiences In Nonprofit Organizations, Trisha W. Lee Jan 2026

She Leads: A Phenomenological Study Of Women's Leadership Experiences In Nonprofit Organizations, Trisha W. Lee

Antioch University Dissertations & Theses

Women comprise a significant portion of the nonprofit sector workforce but are underrepresented in leadership, particularly among executives in larger revenue nonprofit organizations (NPOs). This phenomenological study explored the lived experiences of women who led large, local NPOs (those with annual revenues between $1 million and $5 million) in Ohio. Addressing a gap in understanding the intersection of gender and leadership in large revenue NPOs, this research compared women who were founders of their NPOs with women who ascended to leadership in established organizations. Did founding one’s own NPO provide an advantage in leading it once it grew? How did …


Against Audiepistemic Injustice: Claiming Deaf Futurity, Pamela R. Conley Jan 2026

Against Audiepistemic Injustice: Claiming Deaf Futurity, Pamela R. Conley

Antioch University Dissertations & Theses

This dissertation proposes a new theoretical framework: Audiepistemic Injustice (AEI). Expanding upon existing theories of epistemic injustice (EI), I identify AEI as the systemic marginalization and dismissal of deaf ways of knowing. AEI is a multidimensional phenomenon rooted in the nineteenth century, when auditory and linguistic biases became codified across education, law, and literature. This interdisciplinary study interrogates three nineteenth-century literary narratives as primary case studies to examine AEI: (1) Ivan Turgenev’s “Mumu,” (2) Guy de Maupassant’s “The Deaf Mute,” and (3) Abigail Bradley Hyde’s “The Deaf and Dumb Child: A True Narrative.” I synthesize these literary works with legal …


Beyond The Rabbit Hole: Dmt, Death, And The Hereafter, Abby Molina Jan 2026

Beyond The Rabbit Hole: Dmt, Death, And The Hereafter, Abby Molina

Antioch University Dissertations & Theses

This dissertation explores a proposed relationship between death and N,N-dimethyltryptamine (DMT) within the context of contemporary clinical psychology and the current psychedelic renaissance. Building on Rick Strassman’s hypothesis that DMT may be released at the moment of death and Imants Barušs’ conceptualization of death as an altered state of consciousness, this project examines the phenomenological similarities between DMT-induced experiences (psychedelic “trips”) and near-death experiences (NDEs). Through review of neurobiological research, psychedelic-assisted therapy literature, religious and cultural ceremonial practices, and documented DMT trip and NDE reports, this work evaluates the plausibility that endogenous DMT contributes to altered states of consciousness observed …


Hospitality As A Philosophy Of Care, Freddy Clark Jan 2026

Hospitality As A Philosophy Of Care, Freddy Clark

Antioch University Dissertations & Theses

This study examines hospitality as a philosophy of care and a practice of social justice, particularly within marginalized communities. While hospitality is often understood as a gesture of kindness or a function of the service industry, this research reframes it as an ethical and relational practice grounded in human dignity, mutuality, and community formation. It explores how hospitality extends beyond transactional exchanges to become a transformative expression of care that challenges exclusion and affirms belonging. Drawing on interdisciplinary frameworks, the study integrates biblical narratives, including the Good Samaritan and Matthew 25:35–40, philosophical perspectives from Emmanuel Levinas and Jacques Derrida, and …


Green Space: Investigation Into The Role Pocket Parks Play In Biodiversity And Human Well-Being, Jacalyn Speicher Jan 2026

Green Space: Investigation Into The Role Pocket Parks Play In Biodiversity And Human Well-Being, Jacalyn Speicher

Antioch University Dissertations & Theses

Natural communities and the birds that inhabit them are essential to the physical and emotional well-being of human residents in urban settings. The action research undertaken in this study addresses the social and environmental justice issues of equity, accessibility, and diversity afforded avian and human communities in the design of pocket parks within the urban landscape. As urbanization consumes the natural landscape, people and birds must adapt to the novel challenges of a changing environment. I studied 10 pocket parks identified in Center City, Philadelphia, Pennsylvania between January and June 2026. This time frame spanned the seasons from winter to …


Improving Parental Self-Efficacy In An Integrated Primary Care Setting, Leo Parini Jan 2026

Improving Parental Self-Efficacy In An Integrated Primary Care Setting, Leo Parini

Antioch University Dissertations & Theses

A pediatric mental health crisis in the United States has strained integrated primary care, leaving providers with high volumes of requests for psychotherapy. Low parental self-efficacy (PSE)—reduced caregiver confidence in supporting children's emotional and behavioral needs—may contribute to this demand. This study examined whether a brief, 4-week parent training curriculum informed by Supportive Parenting for Anxious Childhood Emotions (SPACE), targeting child anxiety and obsessive-compulsive disorder (OCD) and delivered by a clinical psychologist within an integrated primary care setting, would increase PSE. Using secondary, de-identified data, PSE was measured before and after the course with the Brief Parental Self-Efficacy Scale; 19 …


University Of Richmond Magazine - Summer 2026 Jan 2026

University Of Richmond Magazine - Summer 2026

University of Richmond Magazine

No abstract provided.


Between Care And Protection: Constraints On Political Authority In Kamala Harris's 2024 Presidential Campaign, Marissa Barbara Pax Jan 2026

Between Care And Protection: Constraints On Political Authority In Kamala Harris's 2024 Presidential Campaign, Marissa Barbara Pax

Graduate Student Theses, Dissertations, & Professional Papers

Competing expectations about strength, care, and protection shape how presidential leadership and authority are constructed in contemporary U.S. politics, particularly for members of marginalized communities. This thesis examines Kamala Harris’s 2024 presidential campaign as a case study to explore how candidates negotiate competing understandings of political authority through appeals to Lakoff’s (2002, 2008) Strict Father Morality and the Nurturant Parent Morality. An analysis of her campaign reveals that Harris repeatedly appeals to both moral frameworks, constructing authority through empathy, mutual responsibility, and care while also emphasizing threat identification, protection, discipline, and moral strength. Although Harris successfully mobilizes the rhetorical resources …


The Importance Of The Proline Residue In The Ldiapa Motif Of Cholera Toxin, Akash Bharathan Jan 2026

The Importance Of The Proline Residue In The Ldiapa Motif Of Cholera Toxin, Akash Bharathan

Honors Undergraduate Theses

Cholera is currently on its seventh global pandemic, disproportionately affecting developing countries. Vibrio cholerae, the bacterial etiologic agent, is able to cause infection by adhering to intestinal epithelial cells and secreting cholera toxin (CT), an AB-type exotoxin that dysregulates signaling pathways. Previous research by the Teter lab has shown that Hsp90, a host cytosolic chaperone, is required for CT to enter the cytosol where it produces toxic effects. Hsp90 binds to CT at two specific motifs, RPPDEI and LDIAPA. The prolines in the RPPDEI motif are essential for binding, but the proline in the LDIAPA has yet to be …


Aquatic Invasive Species Survey And Treatment On Lake Umatilla And Lake Celilo 2024-2025 Report, Jacob Rose, Gabriel E. Campbell Jan 2026

Aquatic Invasive Species Survey And Treatment On Lake Umatilla And Lake Celilo 2024-2025 Report, Jacob Rose, Gabriel E. Campbell

Center for Lakes and Reservoirs Publications and Presentations

Flowering Rush (Butomus umbellatus) is an invasive aquatic plant in the Pacific Northwest that threatens salmon habitat. The Center for Lakes and Reservoirs staff surveyed for this and other aquatic species from 2024 and 2025 in the Columbia River in Lake Umatilla and Lake Celilo. This document summarizes their survey efforts including their protocols, data, and small-scale removal efforts.


A Note On The Novel Passive Sampling In Environmental Dna (Edna) Collection Technique To Detect Yellow Mud Turtle (Kinosternon Flavescens): Field And Laboratory Approaches In Turtle Edna, Sakib Tahmid Rishan, Richard J. Kline, Md. Saydur Rahman Jan 2026

A Note On The Novel Passive Sampling In Environmental Dna (Edna) Collection Technique To Detect Yellow Mud Turtle (Kinosternon Flavescens): Field And Laboratory Approaches In Turtle Edna, Sakib Tahmid Rishan, Richard J. Kline, Md. Saydur Rahman

School of Integrative Biological & Chemical Sciences Faculty Publications

Environmental DNA (eDNA) is a powerful and sensitive method for monitoring aquatic and terrestrial organisms, offering insights into their distribution. Usually, eDNA is collected using a filter membrane through water filtration. However, the passive eDNA method can simplify sampling and broaden its scope, offering new insights for ecological surveillance. This study examined the efficacy of six different membrane filters in detecting the yellow mud turtle (Kinosternon flavescens) through a novel passive eDNA method. After being immersed in water for 12 h, only the mixed cellulose ester (MCE) membrane filter consistently demonstrated specific polymerase chain reaction (PCR) amplification using …


Healthy Places Healthy People Toolkit: A Resource For The Navajo Nation, Sally Davis, Elijah Maas Jan 2026

Healthy Places Healthy People Toolkit: A Resource For The Navajo Nation, Sally Davis, Elijah Maas

Healthy Places, Healthy People Toolkit

The University of New Mexico’s Prevention Research Center (UNM PRC) developed an evidence-based model to increase physical activity in rural communities in NM. Starting in the small, rural town of Cuba, NM, the model was expanded to other rural communities. Given the success of the model, the PRC was invited to partner with 10 Navajo Chapters (communities) in the Eastern Agency of the Navajo Nation, with funding from the Centers for Disease Control and Prevention (CDC). Together, they engaged in a project called Healthy Places— Healthy People.


Simulating Current And Future Ev Growth Scenarios In Indiana, Omar Faruqe Hamim, Xiaowei Chen, Kenny Chandra Wijaya, Lavan Teja Burra, Zengxiang Lei, Rajat Verma, Konstantina (Nadia) Gkritza, Satish Ukkusuri Jan 2026

Simulating Current And Future Ev Growth Scenarios In Indiana, Omar Faruqe Hamim, Xiaowei Chen, Kenny Chandra Wijaya, Lavan Teja Burra, Zengxiang Lei, Rajat Verma, Konstantina (Nadia) Gkritza, Satish Ukkusuri

JTRP Technical Reports

As Indiana transitions toward electric mobility, data-driven planning is essential to guide electric vehicle (EV) charging infrastructure investment and deployment. This study evaluates the current and future performance of Indiana’s EV charging infrastructure using Multimodal Energy-Efficient Trip Simulation in Real Time (METS-R), a high-resolution simulation platform. Five EV adoption scenarios, ranging from pessimistic to optimistic, are modeled for the years 2024 through 2031, to assess spatial and temporal variations in public charging demand. Results reveal increasing public charging demand under high adoption scenarios, with significant disparities between urban and non-urban areas. Accessibility to public charging is found to be uneven …


Scholarly Productivity Of Non–Pharmacy Practice Faculty In U.S. Schools And Colleges Of Pharmacy, 2019–2023, Osama A. Shoair, Sierra Pollard, Faith Fosuhene-Apenteng, Michael Pimentel-Galvan, Abrar Elagami, May H. Abdelaziz Jan 2026

Scholarly Productivity Of Non–Pharmacy Practice Faculty In U.S. Schools And Colleges Of Pharmacy, 2019–2023, Osama A. Shoair, Sierra Pollard, Faith Fosuhene-Apenteng, Michael Pimentel-Galvan, Abrar Elagami, May H. Abdelaziz

Pharmacy Faculty Publications and Presentations

Purpose: Scholarly productivity is central to academic advancement, institutional benchmarking, and accreditation in pharmacy education. This study evaluated the national scholarly productivity among non–pharmacy practice (NPP) faculty in U.S. schools and colleges of pharmacy and assessed variation in publication output across faculty and institutional characteristics.

Methods: A retrospective bibliometric analysis was conducted between January 2019 and December 2023. Faculty were identified using the American Association of Colleges of Pharmacy Roster of Faculty and Professional Staff and classified as biomedical and pharmaceutical sciences (BPS) or social and administrative sciences (SAS). Publications were retrieved from Web of Science and characterized …


The Interplay Between Loneliness, Cortisol, And Nk Cell Function: The Role Of Cortisol In Nk Cell Dysfunction, Abhinav Saurabh, Yvonne Baumer, Laurel G. Mendelsohn, Elizabeth M. Aquino Peterson, Dana Sadler, Shirley J. Lopez De Leon, Ayushi Dave, Andrew S. Baez, Lola R. Ortiz-Whittingham, Mario A. Pita, Manuel A. Cintron, Hannatu A. Tarfa, Sandy T. Reynolds, Shelby R. Hicks, Sonal Sharda, J. Eleanor Seo, Maria Lopez-Ocasio, Pradeep K. Dagur, Skyler A. Kuhn, Neelam R. Redekar, James F. Troendle, Ayanna L. Wells, Marie Marah, Katherine J. Tolentino, Michael J. Corley, Alika K. Maunakea, Lynnette K. Nieman, Marcus R. Andrews, Tiffany M. Powell-Wiley Jan 2026

The Interplay Between Loneliness, Cortisol, And Nk Cell Function: The Role Of Cortisol In Nk Cell Dysfunction, Abhinav Saurabh, Yvonne Baumer, Laurel G. Mendelsohn, Elizabeth M. Aquino Peterson, Dana Sadler, Shirley J. Lopez De Leon, Ayushi Dave, Andrew S. Baez, Lola R. Ortiz-Whittingham, Mario A. Pita, Manuel A. Cintron, Hannatu A. Tarfa, Sandy T. Reynolds, Shelby R. Hicks, Sonal Sharda, J. Eleanor Seo, Maria Lopez-Ocasio, Pradeep K. Dagur, Skyler A. Kuhn, Neelam R. Redekar, James F. Troendle, Ayanna L. Wells, Marie Marah, Katherine J. Tolentino, Michael J. Corley, Alika K. Maunakea, Lynnette K. Nieman, Marcus R. Andrews, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

Chronic psychosocial stressors contribute to cardiovascular disease (CVD) and related risk factors, particularly in under-resourced communities. Psychosocial stressors activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to sustained cortisol action on immune cells. Natural killer (NK) cells are altered in distribution and function in cardio-metabolic diseases; however, pathways linking cortisol as a marker of chronic stress to NK cell dysfunction remain understudied. We recruited 186 African American women from the Step It Up Community-Engaged, Digital Health Physical Activity Intervention study and collected cortisol, NK cell measures, and psychosocial stress measures using validated questionnaires, including chronic stress and loneliness. Plasma cortisol levels were …


The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo Jan 2026

The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

Substance use disorders (SUDs) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (ROS) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused substances including alcohol, cocaine, …


Redefining Family Law, 2026: New State Laws From 2025, Family Law Quarterly 2025–2026 Editors, New York Law School Jan 2026

Redefining Family Law, 2026: New State Laws From 2025, Family Law Quarterly 2025–2026 Editors, New York Law School

Redefining Family Law: State Legislative Updates

This is the fifth annual Family Law Quarterly article discussing new state family laws that were enacted in the previous year. The article discusses 34 laws from 27 states, New York City, and the District of Columbia, grouped into the following categories: (1) Child Welfare, (2) Parents’ and Children’s Rights, (3) Parentage, (4) Child Custody and Visitation, (5) Financial Support, (6) Domestic Violence, and (7) Technology and Artificial Intelligence. Specific topics of the laws featured in this article include, among others: • Restrictions on anonymous reports of child abuse and neglect (New York); • Protections for gender-affirming and reproductive health …


Senescent Fibroblasts In Aging And Pulmonary Fibrosis, Sara B. Palega, Aiwei Y. Borengasser, Yan Y. Sanders Jan 2026

Senescent Fibroblasts In Aging And Pulmonary Fibrosis, Sara B. Palega, Aiwei Y. Borengasser, Yan Y. Sanders

Microbiology & Molecular Cell Biology Faculty Publications

Aging is a major risk factor for many chronic lung diseases, including Idiopathic Pulmonary Fibrosis (IPF), a fatal and incurable disease characterized by progressive fibrotic remodeling. Age-associated structural alterations, impaired regenerative capacity, and dysregulated cellular signaling collectively create a pro-fibrotic microenvironment. A central driver of this pathological shift is the accumulation of senescent cells, which undergo irreversible growth arrest and develop a robust pro-inflammatory senescence-associated secretory phenotype (SASP). Emerging evidence identifies senescent lung fibroblasts as critical mediators of IPF pathogenesis. These cells promote excessive extracellular matrix deposition, myofibroblast differentiation, and tissue stiffening, while simultaneously impairing epithelial regeneration. Together, these effects …


Single-Cell Transciptomic Analysis Reveals Age-Related Remodeling Of Brain Endothelial Cells, Hai Duc Nguyen, Summer Siddiqui, Diana G. Bohannon, Robert V. Blair, Hong-Wen Deng, Alexandre Prat, Woong-Ki Kim Jan 2026

Single-Cell Transciptomic Analysis Reveals Age-Related Remodeling Of Brain Endothelial Cells, Hai Duc Nguyen, Summer Siddiqui, Diana G. Bohannon, Robert V. Blair, Hong-Wen Deng, Alexandre Prat, Woong-Ki Kim

Microbiology & Molecular Cell Biology Faculty Publications

Blood–brain barrier (BBB) integrity naturally declines with age. Brain endothelial cells (ECs) and pericytes (PCs) form the BBB, and aging impairs tight junctions, likely via altered PC-to-EC signaling. However, the molecular mechanisms underlying this impairment remain unclear. Using single-cell RNA sequencing, we profiled 68,316 brain ECs expressing 15,564 genes from young and old mice. Unsupervised clustering and annotation revealed five distinct EC subtypes—Capillary EC1, Capillary EC2, Arterial EC, Venous EC1, and Venous EC2—defined by marker genes Mfsd2a, Plvap, Bmx, Nr2f2, and Vcam1, respectively. Aging shifted EC subtype distribution, with reduced Capillary EC1 (45% vs. 57%) and increased Arterial …


Mepolizumab Improves Outcomes In Patients With Crswnp With One Or More Prior Nasal Polyp Surgeries, Joseph K. Han, Joaquim Mullol, Martin Wagenmann, Laura Walrave, Lingjiao Zhang, Ana R. Sousa, Peter Howarth, Claire Hopkins Jan 2026

Mepolizumab Improves Outcomes In Patients With Crswnp With One Or More Prior Nasal Polyp Surgeries, Joseph K. Han, Joaquim Mullol, Martin Wagenmann, Laura Walrave, Lingjiao Zhang, Ana R. Sousa, Peter Howarth, Claire Hopkins

Department of Otolaryngology (ENT) Faculty Publications

BACKGROUND: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often undergo multiple nasal surgeries. The Phase III SYNAPSE study (GSK ID:205687; NCT0308579) demonstrated that mepolizumab reduces the need for repeat surgery. We explored whether outcomes differed based on the number of prior surgeries. METHODOLOGY: This post hoc analysis of SYNAPSE stratified patients by history of 1 or more than 1 prior surgery. Patients were randomised to receive mepolizumab or placebo every 4 weeks, alongside standard of care, for 52 weeks. Outcomes included change from baseline in endoscopic nasal polyp (NP) score, visual analogue scale (VAS) scores for nasal obstruction, loss …


Clinical Microbiology & Infectious Diseases: A Concise Guide On The Fundamentals Of Infectious Disease In Podiatric Medical Education, Paramita Basu Jan 2026

Clinical Microbiology & Infectious Diseases: A Concise Guide On The Fundamentals Of Infectious Disease In Podiatric Medical Education, Paramita Basu

Open Touro Created

2026

This Open Educational Resource (OER), Clinical Microbiology & Infectious Diseases, is a student-centered textbook designed to support pre-clinical podiatric medical students enrolled in PCLP 610 Infectious Diseases at the New York College of Podiatric Medicine. The book is structured as a collection of concise “chapter briefs” or high‑yield notes that align closely with the course syllabus, lecture objectives, and student learning outcomes, while also reflecting the Microbiology learning objectives outlined in the AACPM Council of Faculties Curricular Guide.

The content covers core principles of medical microbiology and infectious diseases, including bacteria, viruses, fungi, parasites, host–pathogen interactions, antimicrobial therapy, resistance …


External Validation Of A Knowledge-Based Clinical Toxicology Consultant For Diagnosing Single Exposures, Hugo Lerogeron, Joel D. Schipper, Jay L. Schauben, Laurent Guéguen, Valentine Lacotte, Kim An Nguyen Jan 2026

External Validation Of A Knowledge-Based Clinical Toxicology Consultant For Diagnosing Single Exposures, Hugo Lerogeron, Joel D. Schipper, Jay L. Schauben, Laurent Guéguen, Valentine Lacotte, Kim An Nguyen

Publications

Introduction

Clinical prediction models assist healthcare providers in estimating disease likelihood using multiple patient-specific factors. While these models are increasingly used, few undergo the essential process of external validation, which limits their clinical utility. In toxicology, timely diagnosis is crucial and expertise scarce, making knowledge-based systems an excellent choice to support medical decision making. A knowledge-based system developed using data from the Florida Poison Information Center Network has shown promise but lacks external validation. This study aims to evaluate its performance using data from the Lyon Poison Information Center to assess its generalizability

Methods

To externally validate the Florida diagnostic …