Digital Commons Network^™

Volumetric Fluorescence Microscopy For High-Throughput And High-Sensitivity Imaging: From Single Molecules To Tissues, Le-Mei Wang

Graduate Studies Theses and Dissertations 2026

Fluorescence microscopy is an indispensable tool in the biological sciences, enabling researchers to investigate intricate subcellular structures, particularly for volumetric studies. However, conventional optical microscopy for volumetric imaging remains fundamentally constrained by imaging speed and throughput. To bypass traditional serial z-scanning, we introduce an axially scan-free method using a phase layer cake to modulate the system's point spread function. This approach projects volumetric information onto a 2D plane in a single shot, offering high flexibility in tuning axial depth alongside simultaneous multicolor imaging with high spatial resolution and sensitivity. This dissertation divides these technical advancements into cellular and tissue imaging …

Phytoremediation Potential Of Selected Plant Species (Ambrosia Artemisiifolia L. And Erigeron Canadensis L.) For Reducing Priority Heavy Metal And Metalloid (As, Cd, Cr, Cu, Hg, Pb, Zn) Contamination In Anthropogenically Impacted Soils Of Ukraine, Volodymyr Laptiev

Theses

Soil contamination with priority heavy metals and metalloids of anthropogenic origin represents one of the most pressing environmental challenges of the present day, directly associated with risks to public health, ecosystem degradation, and the achievement of the Sustainable Development Goals, particularly those of the World Health Organization and the United Nations aimed at ensuring a healthy environment, safe ecosystems, and sustainable land management. Under conditions of long-term technogenic pressure, compounded by the additional impact of military activities on the territory of Ukraine, the search for scientifically substantiated, environmentally safe, and economically feasible approaches to reducing soil contamination has become especially …

To The Hague And Beyond: The Shifting Terrain Of International Criminal Justice, Leila Nadya Sadat, Valerie Oosterveld, Sharon Weil, Nancy Combs, David Crane

Faculty Publications

Panel of international criminal law experts speak about the areas in which they work.

One Family Under Kim:, Jared Johnson

BYU Asian Studies Student Journal

The Democratic People’s Republic of Korea (D.P.R.K. or the state), as one of the most isolated and controlled states in Asia, has since its founding attempted to shape the culture and ideology surrounding the family construct to support the rule of the socialist regime and its leaders, the Eternal President, Kim Il Sung, and his successors. In Korea, like the rest of East Asia, the traditional family unit has been a central societal structure for centuries. Largely based upon Confucianism, the nuclear family—referring generally to the biological family unit of parents and children—has determined not only the lifestyle and livelihood …

The Idea Of Air, Jonathan Skinner-Thompson

Publications

How we view air, especially clean air, has meaningful normative and practical implications. Today, it is commonly recognized as an exhaustible natural resource. But air was not always thought of as something to be conserved, developed, and used. This Article is the first to explore and interrogate that view.

The shift to seeing air as a resource started in the first part of the twentieth century. Previously, air was characterized by its limitless supply of oxygen: a pure public good. Over time, the quality of that good changed, and a precious resource emerged. That resource—especially its chemical and physical characteristics—inspired …

Finite Ventures, Andrew A. Schwartz

Publications

The law endows corporations and other business organizations with the awesome power of perpetual life—unless the charter expressly provides for a certain duration, such as ten years. But does anyone ever actually choose limited life? Why would they?

This article reveals that limited-life business entities—finite ventures—play a significant and underappreciated role in modern commerce. Private equity and venture capital funds, SPACs, and insurance syndicates are all organized with a limited lifespan.

Their motivation? This article claims that limited life is a valuable, but often overlooked, tool for ameliorating agency costs: the managers of a finite venture know they must produce …

Gender Therapy False Equivalency, Scott Skinner-Thompson

Publications

One critical dispute surrounding the rights of LGBTQ people and societal recognition of their existence is the legal debate regarding very different types of gender therapy. On the one hand, several states have banned the provision of gender-affirming medical care to transgender youth, positing that it is a dangerous form of mutilation. A separate set of states has banned the practice of so-called gay or gender conversion therapy that seeks to transform youth away from their queer identities, concluding that it is a form of abuse. Both sets of laws have been challenged in courts with the Supreme Court recently …

The Internet And The Lost Law Of Transit, Vivek Krishnamurthy

Publications

For centuries, the law of transit has specified when states must permit foreign persons and goods to traverse their territory on journeys beginning and ending beyond their borders. Transit is a right — not a privilege — that tempers territorial sovereignty. Though largely forgotten today, the right to transit springs from states’ responsibilities to the international community when their territory hosts infrastructure of global utility.

Yet the internet stands as a striking exception to this tradition. Despite its importance, no doctrine of transit constrains states’ power to block or disrupt internet traffic that merely passes through their territory. This is …

Against A Medical Exception To Equal Protection, Govind Persad

Publications

Government regulations of medicine sometimes treat patients differently based on their race or sex. Does heightened scrutiny apply to such regulations—as is usual when law treats someone differently based on a protected characteristic? Or is there a medical exception to equal protection?

Recently, in United States v. Skrmetti, the Supreme Court upheld a law that restricted access to medical treatments for transgender minors. Though its holding did not rely on medical exceptionalism, its discussion reinvigorated interest in a "medical exception" to equal protection: that medical decisions are exempt from the searching review applied when governmental decisions consider protected characteristics.

For …

Secondary Teachers' Experiences In International Professional Development For Convergence Research In Stem And Tradition, Rachel Sparks White, Kristie S. Gutierrez, James K. Ferri

Teaching & Learning Faculty Publications

Convergence education promotes learning experiences that integrate science, technology, engineering, and mathematics (STEM) to address complex real-world problems. However, secondary teachers often report limited access to professional development (PD) and curricular resources that support transdisciplinary instruction. This exploratory case study examines how four secondary teachers (three chemistry; one engineering) made sense of a transdisciplinary PD model, Convergence Research in STEM and Tradition (CReST), that leverages cultural heritage artifacts (Renaissance frescoes) as boundary objects to connect chemistry, engineering, world history, and technology. Teachers participated in a four-day immersive PD experience in Firenze (Florence) and Pisa, Italy, that included site-based learning, interaction …

'I Want To Learn Biology And Preserve My Culture' Testing The Efficacy Of A Culturally Relevant And Context Specific Approach, Umar Adam, Musa Adekunle Ayanwale, Hafsat Mustapha, Sakibu Olajide Saibu, Tunde Owolabi, Adekunle Ibrahim Oladejo

Teaching & Learning Faculty Publications

Background

The dominance of Western-inspired teaching methods and instructional materials has contributed to cultural erosion in African schools. In response, increasing attention has been directed toward culturally responsive approaches to decolonising science education. One such approach is the Culturo-Techno-Contextual Approach (CTCA), which enables African students to conceptualize science as culturally embedded knowledge, integrated into their everyday experiences and practically relevant to their lived realities.

Purpose

This study examined the potency of the CTCA in enhancing students' achievement in the biology topic of variation, which is widely regarded as conceptually challenging.

Sample

The study involved 105 Senior Secondary II students from …

Pre-Service Elementary Teachers' Science Content Knowledge And Confidence: Teaching Science Methods With Metacognitive Awareness Activities, Demetrice Smith-Mutegi, Erika Wise

Teaching & Learning Faculty Publications

Few elementary teachers are confident in teaching science or in their science knowledge. This study sought to address this concern by investigating the impact of a science methods course on confidence and science knowledge for pre-service elementary teachers (PSETs). In this study, 23 participants enrolled in a teacher education program at a Midwest US university participated in a quasi-experimental pretest-posttest design. The participants engaged in course content, including metacognitive awareness activities, for a full semester and qualitatively described their confidence within the pre-post assessment survey. Results were analyzed using an independent samples t-test, mean content assessment scores, and paired samples …

Pre-Service Teachers' Perceptions Of Literacy In Stem Classroom Instruction By Implementation Of Project-Based Lessons, Sarah Ferguson, Maryam Enderson, Jamie Colwell

Teaching & Learning Faculty Publications

This study examines how project-based learning (PBL) supports pre-service STEM teachers (PSTs) in understanding and applying disciplinary literacy in classroom instruction. Conducted in a semester-long PBL course at a mid-sized public university, the research explores PSTs’ shifting perceptions of literacy in STEM and the challenges and successes they experience. Using qualitative methods grounded in student voice and case study frameworks, data were collected through focus groups, reflections, and lesson plan analyses. Findings show PSTs initially held narrow views of literacy but developed more nuanced understandings through PBL. Key successes included increased confidence and use of inquiry-based strategies; challenges involved time …

On Dark Skinned Jesus Of Nazareth: Why Color Matters, Nicholas Berkel

MA Theses

This thesis examines the historical, religious, and cultural consequences of portraying Jesus as white within Christian art. Although Western art has overwhelmingly depicted Christ with white skin, archaeological, and contextual evidence supports a dark-skinned Jesus rooted in the ethnogeography of first century Palestine. The persistence of a White Jesus has shaped religious imagination and perception for centuries, reinforcing racial hierarchy and legitimizing systems of white supremacy. Through an interdisciplinary analysis combining biblical studies, Christian iconography, ethnography of ancient Semitic, Greco-Roman, and Egyptian peoples, medieval symbolism, modern mass-produced imagery, and Black thought, this study demonstrates how Jesus’ original complexion was gradually …

About Witch Hunt: Feminist And Political Agency In Contemporary Art, Rana Sumerler

MA Theses

The Witch Hunt exhibition conjures a powerful dialogue between history, identity, and empowerment, bringing together sixteen international artists to channel the spirit of the witch. This show traces a vast genealogy of women—from the 15th century witch hunts to Californian artistic legacies of the 1970s, to the exhibitions opening in 2021, and into present day. The participating artists emerge as symbols of resistance through their creations which transform domesticity, sexuality, and labor into sites of inquiry all while grappling with the intersectional concerns of womanhood.  In a moment marked by political upheaval, the exhibition is particularly resonant in its exploration …

A Position Statement On Endovascular Models And Effectiveness Metrics For Mechanical Thrombectomy Navigation, On Behalf Of The Stakeholder Taskforce For Artificial Intelligence-Assisted Robotic Thrombectomy (Start), Harry Robertshaw, Anna Barnes, Phil Blakelock, Raphael Blanc, Robert Crossley, Rebecca Fahrig, Ameer E. Hassan, Benjamin Jackson, Lennart Karstensen

School of Medicine Publications

Although we are making progress in overcoming infectious diseases and cancer, one of the major medical challenges of the mid-21st century will be the increasing prevalence of stroke. Occlusions in large vessels are especially debilitating, yet effective treatment—needed within hours to achieve best outcomes—remains limited because of geographic accessibility. One solution for improving timely access to mechanical thrombectomy in geographically diverse populations is the widespread deployment of robotic surgical systems. Artificial intelligence assistance may enable the safe and effective upskilling of operators in this emerging therapeutic delivery approach. Our aim was to establish consensus frameworks for developing and validating artificial …

Association Between Neighborhood Social Determinants Of Health And Stillbirth, Tetsuya Kawakita, Misa Hayasaka, Ann M. Harper, John Brush, George Saade

Department of Obstetrics & Gynecology Faculty Publications

OBJECTIVE:

To examine the association between neighborhood-level social determinants of health and stillbirth.

METHODS:

We performed a retrospective cohort study of deliveries that occurred at a gestational age of at least 20 weeks within a five-hospital system (2012-2022). Electronic health record data mapped to the Observational Medical Outcomes Partnership Common Data Model were geocoded using addresses at the time of delivery and linked to neighborhood health indices, which included the Area Deprivation Index (ADI), Maternal Vulnerability Index (MVI), and Social Vulnerability Index (SVI) at the Census tract level. Stillbirths were adjudicated by medical record review. Modified Poisson regression generated relative …

Contribution Of Comorbidities And Pregnancy Complications To Severe Maternal Morbidity In The United States, Tetsuya Kawakita, Sora A. Jones, Natsume Furukawa, George Saade

Department of Obstetrics & Gynecology Faculty Publications

Objective: To quantify the extent to which rising rates of severe maternal morbidity (SMM) in the United States from 2016 to 2022 are attributable to increasing prevalence of maternal risk factors, including advanced maternal age, obesity, pregestational diabetes mellitus, gestational diabetes, chronic hypertension, and hypertensive disorders of pregnancy (HDP).

Methods: We conducted a retrospective cohort study using the Nationwide Readmissions Database from 2016 to 2022, representing more than 25 million weighted delivery hospitalizations. The primary outcome of SMM was identified with the Centers for Disease Control and Prevention's 21-condition algorithm; a secondary outcome excluded transfusion to improve specificity. Temporal trends …

Cervicovaginal Lavage Fluid Iron And Manganese Levels In Women With And Without Vaginitis, Barbara Kozma, David Ratonyi, Bence Kozma, Peter Takacs, Attila G. Sipos

Department of Obstetrics & Gynecology Faculty Publications

Transition metals such as iron and manganese are critical for cellular metabolism, redox balance, and immune function, and they also influence host–pathogen interactions. Vaginitis is characterized by mucosal inflammation that may alter local trace-element homeostasis. We hypothesize that inflammatory conditions such as vaginitis may be associated with altered cervicovaginal iron and manganese levels. We performed a prospective, single-center cohort study at the University of Debrecen (Hungary) between April 2023 and April 2024, enrolling 80 women ≥ 18 years with vulvovaginal complaints. Participants were assessed at baseline and at weeks 4, 8, and 12 with clinical evaluation and cervicovaginal lavage (CVL) …

The Association Between The Degree Of Social Vulnerability And Maternal Anemia And Other Adverse Perinatal Outcomes, Rubymel J. Knupp, Christina T. Blanchard, Ariann Nassel, Ashley Shea, Lindsay S. Robbins, Jeff M. Szychowski, Ashley N. Battarbee, Akila Subramaniam

Department of Obstetrics & Gynecology Faculty Publications

Objective

Maternal anemia in pregnancy is associated with many adverse maternal, fetal, and neonatal outcomes. The role of social determinants of health (SDOH) in the development of maternal anemia and other adverse outcomes is continually evolving. One such newer tool, the Social Vulnerability Index (SVI), measures an individual's community-level SDOH, with higher SVI denoting higher vulnerability. Our objective was to evaluate the association between SVI, maternal anemia, and other adverse perinatal outcomes.

Methods

Retrospective cohort study of pregnant individuals delivering singletons at a gestational age ≥23 weeks at a single center from 2014 to 2018. Patients with sickle cell disease, …

Evaluating The Mediating Role Of Gestational Phthalate And Replacement Biomarkers In The Associations Between Race/Ethnicity And Birthweight, Amir J. Lueth, Danielle R. Stevens, Sarahna A. Moyd, Elena Sinkovskaya, Ann Przybylska, Antonia M. Calafat, Julianne C. Botelho, George Saade, Alfred Abuhamad, Kelly K. Ferguson

Department of Obstetrics & Gynecology Faculty Publications

Background

Gestational exposure to phthalates is higher among non-Hispanic black (NHB) women than non-Hispanic white (NHW) women and may contribute to racial/ethnic differences in birthweight z-scores.

Objective

We aimed to investigate whether gestational phthalate and replacement biomarkers mediate the association between race/ethnicity and birthweight z-scores.

Methods

We analyzed data from 271 pregnancies in the Human Placenta and Phthalates study, a prospective cohort recruited from 2017 to 2020. Urinary phthalate metabolite concentrations were measured at up to eight time points during pregnancy and averaged to represent gestational exposure. Metabolites were grouped by parent compound. Linear regression models estimated associations in phthalate …

The Limits Of Daca: Affordability- And Access-Related Barriers To Health Professions Education, Nicole Perez, Laura Hirshfield

Journal of College Access

The U.S. is currently facing a shortage of health professionals from underrepresented backgrounds. One potential pathway to decrease this shortage is through the Deferred Action for Childhood Arrivals (DACA) program, a policy that provides temporary relief from deportation for individuals who migrated to the U.S. before age 16. This study, using 15 life-history narrative interviews, investigates the experiences of Latinx young adults who were pursuing health professions education or working as health professionals. Nine of the participants were DACA recipients, while the remaining six were second-generation (i.e., children of immigrants). An iterative, inductive approach to data analysis was used to …

Dupilumab For Patients With Allergic Fungal Rhinosinusitis, Amber U. Luong, Joshua M. Levy, Sarah K. Wise, Joseph K. Han, Mamoru Yoshikawa, Luo Zhang, Rodney Schlosser, Prerna Ranganathan, Paula Dakin, Jennifer Maloney, George D. Yancopoulos, Andrew P. Fontenot, Neelam A. Phadke, Lacey R. Robinson

Department of Otolaryngology (ENT) Faculty Publications

Background

Allergic fungal rhinosinusitis (AFRS) is a severe subtype of chronic rhinosinusitis characterized by fungal hypersensitivity and accentuated type 2 inflammation. Dupilumab-a fully human monoclonal antibody blocking interleukin-4/13, approved for type 2 inflammatory diseases, including chronic rhinosinusitis with nasal polyps-may benefit patients with AFRS.

Objective

We sought to understand the effect of dupilumab in AFRS

Methods

In this phase 3 trial, patients with AFRS aged ≥6 years were randomized to dupilumab or matched placebo for 52 weeks. The primary end point was Lund-Mackay computed tomography (LMK-CT) score, quantifying sinus opacification, at 52 weeks. Secondary end points were multiplicity-controlled and hierarchically …

Structural Design And Development Of Deployable Propeller Blade, Annan Mashin

Graduate Studies Theses and Dissertations 2026

Aerospace systems frequently face competing requirements between compact packaging and high aerodynamic performance. Large propellers improve efficiency and thrust generation, yet launch constraints and confined storage volumes limit their maximum span. Conventional deployable solutions rely on hinges, locking mechanisms, and external actuation, increasing mechanical complexity and reducing reliability. This dissertation investigates an alternative approach in which elastic instabilities in thin composite shells are deliberately harnessed to enable rapid, mechanism- free deployment of aerodynamic structures. This work harnesses propagating instability in open- section thin-walled airfoil geometries to enable reversible transformation between compact stowed and stiff deployed configurations. By tailoring structural architecture, …

Perceptions Of High School Students’ Sports Participation And Potential Impact On Post-Secondary Involvement, Anthony J. Wishart

Graduate Studies Theses and Dissertations 2026

This dissertation examined the shifting culture of youth sports in the United States and its impact on academic motivation among adolescent student athletes. The study utilized Self-Determination Theory (SDT) as a framework. Traditionally, youth sports have helped students with personal growth and academic success. However, the contemporary emphasis on early sport specialization and the decline of opportunities in nonrevenue male sports are part of broader cultural shifts and require deeper exploration.

This study investigated the relationship between sport specialization among high school male junior and senior student athletes and their levels of academic motivation, as well as the consequences of …

Establishment Of An In Vitro Dss-Induced Epithelial Injury Model To Investigate Il-6 Signaling And Microbial Metabolite Mediated Barrier Recovery, Srijal Kunwar

Graduate Studies Theses and Dissertations 2026

Dextran sodium sulphate (DSS) is widely used in vivo to induce epithelial injury; however, the molecular effects of DSS on intestinal epithelial cells, that investigate inflammatory and metabolic repair mechanisms remain unclear. Here, we establish an in vitro DSS-induced epithelial damage model using differentiated Caco-2 cell monolayer. Exposure to 2.5%(w/v) DSS for 24 hours resulted in significant upregulation of pore forming protein Claudin-2(2.677-fold) and oxidative marker, NOX-1(1.866-fold), accompanied by increased ROS production confirmed via DHE staining. Increased epithelial permeability was observed by TEER analysis, without significant cytotoxicity. Surprisingly, ELISA analysis revealed significant downregulation of IL-6 (p-value …

Mapping Cave Vulnerability And Priority Areas For Biospeleological Conservation, C. Lael Anderson

Theses

Alabama contains some of the highest levels of subterranean biodiversity in North America, yet no statewide assessment of cave vulnerability has previously been conducted. A spatially explicit vulnerability assessment was developed for Alabama caves using species occurrence records, landscape characteristics, anthropogenic threat data, and groundwater vulnerability metrics. Distribution maps were generated for cave- obligate and bat species, and vulnerability was assessed using human population, land- use, groundwater quality, groundwater quantity, and modified DRASTIK models. Results identified numerous single-site endemic species, regional biodiversity hotspots, and cave systems facing elevated anthropogenic threats. Conservation priority rankings highlighted species and caves of greatest management …

Design And Characterization Of A Low-Power Bulk-Driven Two-Stage Ota In 65nm, 90nm, And 130nm Cmos Technologies For 0.4v-0.6v Biomedical Applications, Raihan Khan Akash

Theses

Biomedical instrumentation requires low-power amplifiers to maximize battery life. Due to threshold voltage limitations, standard gate-driven operational transconductance amplifiers (OTAs) require higher supply voltages. To overcome this, a differential bulk-driven two-stage OTA is introduced for low-power applications. The proposed topology is implemented in 65nm, 90nm, and 130nm complementary metal-oxide-semiconductor (CMOS), with supply voltages ranging from 0.4V to 0.6V. Key metrics such as DC gain, gain-bandwidth product (GBWP), phase margin, common-mode rejection ratio (CMRR), slew rate, power, and noise are measured. The analysis confirms the robustness of the low-power solution provided by the proposed topology.

The Future Of The English Class Essay: Reimagining Multimodal Composition In The Chatgpt Era, Taylor Rose-Dougherty, Christy Goldsmith

The Utah English Journal

As English teacher educators, we are on the frontlines of navigating the technological elephant in the 2025 writing classroom: Generative Artificial Intelligence (GenAI) technologies like ChatGPT, Claude, and Gemini that can produce pages of text in mere seconds. English teachers’ philosophies on GenAI are as diverse as their preferred novels or their favorite poets. But, as the two dozen publications in major English education journals1 in the past two years suggest, what is at stake is not the end of high school English (Herman, 2022), but the opportunity to give it a makeover (Herman, 2023) by reimagining what writing experiences …

Teaching Students To Write For The Future By Writing For The Present, Amber Jensen, Meridith Reed

The Utah English Journal

“When you get to eighth grade, you’ll need to know how to write a topic sentence.”

“The five-paragraph essay will prepare you to write in high school.”

“College professors expect you to accurately cite your sources in MLA format.”

“When you graduate from college, you need to be able to write a professional email.”

Perhaps you heard messages like these from your writing teachers as you moved through middle school, high school, college, and into your careers. We certainly did. And perhaps, like we have, you have been a writing teacher in a middle school, high school, or college classroom …