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Articles 16981 - 17010 of 18205
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Nonbinary Gender Performance And Self-Identification In Mary Shelley's Frankenstein, Lillian R. Durr
Nonbinary Gender Performance And Self-Identification In Mary Shelley's Frankenstein, Lillian R. Durr
Graduate Theses/Dissertations
Mary Shelley’s 1818 novel Frankenstein, a text informed by a rich Romantic era philosophical tradition, has produced an expansive contemporary body of transgender studies scholarship. Building on transgender literary studies of Frankenstein, my thesis analyzes the difference between the monster’s internalized self-perceived identity and their externally performed and perceived identity. I interpret the difference between the monster’s internal and external identity as an analogy through which to understand contemporary nonbinary experiences. The “performance” of gender that Judith Butler describes is a limited expression of an internal, inescapable, ontological experience of self-identification. The monster’s own social experience illustrates the …
Characterization Of The Effects Of Atp On Primary Brainstem Glial Cells, Donovan J. Aardema Faigh
Characterization Of The Effects Of Atp On Primary Brainstem Glial Cells, Donovan J. Aardema Faigh
Graduate Theses/Dissertations
Migraine and temporomandibular joint disorder (TMD) are debilitating orofacial pain disorders that negatively impact one’s quality of life. These disorders are characterized by elevated levels of adenosine triphosphate (ATP) and activation of central nervous system glial cells that promote and maintain central sensitization and enhance pain signaling in response to inflammatory stimuli. The goal of my study was to characterize the effects of the pro-inflammatory signaling molecule adenosine triphosphate (ATP) on intracellular calcium levels, mRNA levels, and protein expression in astrocytes, microglia, and oligodendrocytes to better understand the role of ATP in promoting central sensitization. To address this goal, primary …
Genomic Signatures Of Decline And Recovery In An Endangered Bat, Myotis Grisescens, Marxe Altman-Orbach
Genomic Signatures Of Decline And Recovery In An Endangered Bat, Myotis Grisescens, Marxe Altman-Orbach
Graduate Theses/Dissertations
Tremendous population declines may result in the loss of genetic diversity, which can, in turn, lead to reduced adaptive potential, overexpression of deleterious phenotypes, and further population declines. In this way, genetic drift from a severe demographic decline may ultimately lead to an extinction vortex. However, populations that avoid the loss of genetic diversity may remain viable, despite demographic crashes. Therefore, understanding genetic diversity is vital for assessing the conservation status of species that have undergone declines, and can even reflect the effectiveness of management actions. I investigated signatures of genetic bottlenecks in the gray bat (Myotis grisescens), …
United States Mainstream Meat Market Entry: An Analysis On Speciality Goat Meat Products, Madison Raye Schmitz
United States Mainstream Meat Market Entry: An Analysis On Speciality Goat Meat Products, Madison Raye Schmitz
Graduate Theses/Dissertations
Understanding consumers' perspectives and motivations is key when looking into making goat meat more accepted in the mainstream meat market. Previous research has shown there is a demand for goat meat from different populations in the US. Consumers also care more about the quality of the food they purchase. Understanding that goat meat has lower cholesterol and is leaner than other red meat is important to incorporating goat meat in niche consumer markets. Providing consumers with a product that is familiar to them is more acceptable than giving consumers a cut of meat they are unfamiliar with. Standard products like …
Exploring Factors Mediating White-Nose Syndrome In Little Brown Bats, Carly R. Trujillo
Exploring Factors Mediating White-Nose Syndrome In Little Brown Bats, Carly R. Trujillo
Graduate Theses/Dissertations
The little brown bat (Myotis lucifugus) has experienced drastic population declines across North America due to the recent disease white-nose syndrome (WNS). Previous studies have identified putatively adaptive alleles (PAAs) that may give individuals a greater likelihood of survival. However, there could be geographic-specific adaptation, creating different adaptive landscapes. Additionally, there may be energetic trade-offs between disease survival and reproductive output, and it is not clear what the long-term survival outcomes for the species may be as a result. Long-term evolutionary outcomes are unclear because this species has a lifespan exceeding the arrival of WNS and is difficult …
The Effect Of Sex On A-To-I Editing In Skeletal Muscle During Inflammation, Skyler Lee
The Effect Of Sex On A-To-I Editing In Skeletal Muscle During Inflammation, Skyler Lee
Graduate Theses/Dissertations
Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional mechanism mediated by ADAR enzymes that can alter RNA sequence, protein function, and gene regulation. Because ADAR1 is upregulated during inflammation and plays a critical role in innate immunity, previous studies investigated the effects of acute inflammation on RNA editing in male and female mice. Lipopolysaccharide (LPS) was used to induce inflammation, and RNA editing levels were examined in the heart, brain, and skeletal muscle. While editing levels in the heart and brain remained unchanged, skeletal muscle exhibited tissue- and sex-specific differences in editing. In this thesis, LPS treatment affected selective editing, increasing …
Operationalizing Cyber-Routine Activities Theory For Senior Cybercrime Prevention: An Evaluation Of The Shield Training-The-Trainer Program, Kyung-Shick Choi, Insun Park, Mijin Kim, Ji Yae Bong
Operationalizing Cyber-Routine Activities Theory For Senior Cybercrime Prevention: An Evaluation Of The Shield Training-The-Trainer Program, Kyung-Shick Choi, Insun Park, Mijin Kim, Ji Yae Bong
International Journal of Cybersecurity Intelligence & Cybercrime
Older adults face growing risks of cyber-enabled fraud, yet scalable, evidence-based prevention programs remain limited. Guided by Cyber-Routine Activities Theory (Cyber-RAT), this study evaluates the pilot implementation of the Seniors Harnessing Internet Education for Lasting Defense (SHIELD) Training-the-Trainer program, designed to prepare law enforcement officers and community leaders to deliver cybercrime prevention education to older adults. A key innovation of SHIELD is its integration of interactive game-based simulations, which allow participants to practice verification, refusal, and reporting behaviors in realistic cybercrime scenarios. Following the December 2025 pilot session in Boston, semi-structured interviews were conducted with 12 participants from law enforcement, …
Health Truth To Power: Professional Collaboration To Bolster Trust Against Misinformation, William M. Sage, Keegan D. Warren
Health Truth To Power: Professional Collaboration To Bolster Trust Against Misinformation, William M. Sage, Keegan D. Warren
Faculty Scholarship
This Article is about health, leaving aside more general challenges to shared civic information today. The Article begins by surveying the principal challenges for health information in post-pandemic, arguably post-truth America, and then describes briefly the sources and limits of medical professional authority. Noting the double-edged sword of free speech guarantees under the U.S. Constitution, the Article continues by commenting on speaking truth to government, to industry, and to the crowd. Next, the Article considers the physicians’ role in speaking truth to power from the perspective of standard medical professional ethics and identity, comparing it to that of lawyers. Finally, …
Using Genetic Analysis To Infer Familial Relationships Of Westslope Cutthroat Trout In The Lower Priest River, Idaho, Kolby Emtman
Using Genetic Analysis To Infer Familial Relationships Of Westslope Cutthroat Trout In The Lower Priest River, Idaho, Kolby Emtman
EWU Masters Thesis Collection
The Westslope Cutthroat Trout (Oncorhynchus lewisi) is a native species of salmonid that holds both cultural and ecological significance in the Idaho Panhandle region of the United States. Within this region, the Priest River is a major contributor of migrant Westslope Cutthroat Trout to the Clark Fork Pend Oreille basin. This study aimed to estimate the proportion of juveniles that have at least one migrant parent, illustrate gene flow using juvenile half sibling relationships, and showcase varying levels of spawning success using juvenile full sibling relationships. Sampling of juvenile individuals occurred in 11 tributaries of the Priest River over …
Dietary Ecology Of Waterfowl Nest Predators In The Prairie Pothole Region: Evaluating Resource Use From Species To Individual Using Stable Isotope Analysis, Grace Barthelmess
Dietary Ecology Of Waterfowl Nest Predators In The Prairie Pothole Region: Evaluating Resource Use From Species To Individual Using Stable Isotope Analysis, Grace Barthelmess
EWU Masters Thesis Collection
Nest predation is a primary factor influencing waterfowl productivity in the Prairie Pothole Region (PPR) of North America. Although this system is intensely managed and studied, research has largely focused on how predators affect waterfowl populations, with comparatively little attention to how predators actually rely on waterfowl as a resource. Understanding predator feeding ecology is therefore critical for informing effective management strategies and interpreting the complexity of predator-prey interactions on this landscape. My objective overall was to elucidate the feeding ecology of nine focal predator species commonly associated with waterfowl nest predation in the Aspen Parkland Ecoregion of the PPR: …
Assessing Forest Health And Small Mammals After A Limited Suppression Wildfire In Colville National Forest, Samantha J. Kennel
Assessing Forest Health And Small Mammals After A Limited Suppression Wildfire In Colville National Forest, Samantha J. Kennel
EWU Masters Thesis Collection
In the face of a wildfire crisis, there is a growing need to expand the pace and scale of forest treatments, including the strategic use of wildfire as a management tool. However, ecological outcomes remain uncertain in forests shaped by more than a century of fire suppression. The 2022 Thor Fire, a managed wildfire in the Colville National Forest, Washington, provides an opportunity to evaluate forest health in a relatively understudied system. Using a control–impact design, I established 100 monitoring plots in burned and adjacent unburned forests to assess how wildfire and fire severity influence forest structure, fuels, and tree …
Relationships Between Benthic Macroinvertebrate Communities And Environmental Conditions In Headwater Tributaries Of The Pend Oreille Lake Watershed, Idaho, Devlin Mee
EWU Masters Thesis Collection
Benthic macroinvertebrates are widely used indicators of stream condition, and their communities respond to thermal and land-use conditions in headwater streams. This study characterized macroinvertebrate biomass, community composition, and diversity across forested headwater tributaries of the Pend Oreille lake watershed in northern Idaho, and examined their relationships with summer temperature, land development, and road proximity. Samples from thirteen streams collected in 2024 were identified to genus, measured, and converted to estimated biomass using published length–mass regressions; ten streams had recovered temperature loggers. Because environmental variables were characterized once per stream, all analyses were conducted at the stream level.
Estimated total …
Luckett Davis Lecture Notes Collection - Accession 1846, Luckett Vanderford Davis
Luckett Davis Lecture Notes Collection - Accession 1846, Luckett Vanderford Davis
Manuscript Collection
The Dr. Luckett Davis Lecture Notes Collection documents the teaching and academic work of Luckett Vanderford Davis, Professor of Biology at Winthrop University, where he served from 1964 until his retirement and later held the title of Emeritus Professor of Biology. The collection consists primarily of lecture notes, seminar materials, laboratory manuals, and instructional aids used by Dr. Davis in teaching a wide range of undergraduate biology courses.
The bulk of the collection contains handwritten and typed lecture notes prepared for courses in zoology, genetics, evolution, ecology, and marine biology. These materials document Dr. Davis’s approach to teaching biological sciences …
The (Non) Numeric Truths Behind College And Career Aspirations: A Quantcrit Analysis Of The Precarious Pathways For Secondary Students Of Color, Norma A. Marrun, Danielle Mireles, Jori S. Beck, Christine Clark
The (Non) Numeric Truths Behind College And Career Aspirations: A Quantcrit Analysis Of The Precarious Pathways For Secondary Students Of Color, Norma A. Marrun, Danielle Mireles, Jori S. Beck, Christine Clark
Teaching & Learning Faculty Publications
This article explored the college and career choices of 963 students across six urban secondary schools in a large public school district in the Southwestern United States. A Quantitative Critical Race Theory, or QuantCrit, analysis was applied to expose the false narrative of number neutrality and the systemic racism that belies it. Findings demonstrate how the myth of meritocracy through education (as ‘the great equalizer’) is perpetuated when educators hold onto racist and ableist beliefs about who can pursue college, and ignore the structural disadvantages underlying the college and career aspirations of students of Color juxtaposed with the reality of …
Secondary Teachers' Experiences In International Professional Development For Convergence Research In Stem And Tradition, Rachel Sparks White, Kristie S. Gutierrez, James K. Ferri
Secondary Teachers' Experiences In International Professional Development For Convergence Research In Stem And Tradition, Rachel Sparks White, Kristie S. Gutierrez, James K. Ferri
Teaching & Learning Faculty Publications
Convergence education promotes learning experiences that integrate science, technology, engineering, and mathematics (STEM) to address complex real-world problems. However, secondary teachers often report limited access to professional development (PD) and curricular resources that support transdisciplinary instruction. This exploratory case study examines how four secondary teachers (three chemistry; one engineering) made sense of a transdisciplinary PD model, Convergence Research in STEM and Tradition (CReST), that leverages cultural heritage artifacts (Renaissance frescoes) as boundary objects to connect chemistry, engineering, world history, and technology. Teachers participated in a four-day immersive PD experience in Firenze (Florence) and Pisa, Italy, that included site-based learning, interaction …
'I Want To Learn Biology And Preserve My Culture' Testing The Efficacy Of A Culturally Relevant And Context Specific Approach, Umar Adam, Musa Adekunle Ayanwale, Hafsat Mustapha, Sakibu Olajide Saibu, Tunde Owolabi, Adekunle Ibrahim Oladejo
'I Want To Learn Biology And Preserve My Culture' Testing The Efficacy Of A Culturally Relevant And Context Specific Approach, Umar Adam, Musa Adekunle Ayanwale, Hafsat Mustapha, Sakibu Olajide Saibu, Tunde Owolabi, Adekunle Ibrahim Oladejo
Teaching & Learning Faculty Publications
Background
The dominance of Western-inspired teaching methods and instructional materials has contributed to cultural erosion in African schools. In response, increasing attention has been directed toward culturally responsive approaches to decolonising science education. One such approach is the Culturo-Techno-Contextual Approach (CTCA), which enables African students to conceptualize science as culturally embedded knowledge, integrated into their everyday experiences and practically relevant to their lived realities.
Purpose
This study examined the potency of the CTCA in enhancing students' achievement in the biology topic of variation, which is widely regarded as conceptually challenging.
Sample
The study involved 105 Senior Secondary II students from …
Pre-Service Elementary Teachers' Science Content Knowledge And Confidence: Teaching Science Methods With Metacognitive Awareness Activities, Demetrice Smith-Mutegi, Erika Wise
Pre-Service Elementary Teachers' Science Content Knowledge And Confidence: Teaching Science Methods With Metacognitive Awareness Activities, Demetrice Smith-Mutegi, Erika Wise
Teaching & Learning Faculty Publications
Few elementary teachers are confident in teaching science or in their science knowledge. This study sought to address this concern by investigating the impact of a science methods course on confidence and science knowledge for pre-service elementary teachers (PSETs). In this study, 23 participants enrolled in a teacher education program at a Midwest US university participated in a quasi-experimental pretest-posttest design. The participants engaged in course content, including metacognitive awareness activities, for a full semester and qualitatively described their confidence within the pre-post assessment survey. Results were analyzed using an independent samples t-test, mean content assessment scores, and paired samples …
Pre-Service Teachers' Perceptions Of Literacy In Stem Classroom Instruction By Implementation Of Project-Based Lessons, Sarah Ferguson, Maryam Enderson, Jamie Colwell
Pre-Service Teachers' Perceptions Of Literacy In Stem Classroom Instruction By Implementation Of Project-Based Lessons, Sarah Ferguson, Maryam Enderson, Jamie Colwell
Teaching & Learning Faculty Publications
This study examines how project-based learning (PBL) supports pre-service STEM teachers (PSTs) in understanding and applying disciplinary literacy in classroom instruction. Conducted in a semester-long PBL course at a mid-sized public university, the research explores PSTs’ shifting perceptions of literacy in STEM and the challenges and successes they experience. Using qualitative methods grounded in student voice and case study frameworks, data were collected through focus groups, reflections, and lesson plan analyses. Findings show PSTs initially held narrow views of literacy but developed more nuanced understandings through PBL. Key successes included increased confidence and use of inquiry-based strategies; challenges involved time …
"Art, Esthetics, Ideal": An Ethics For Literary Translators In The Age Of Translating Machines, Gabriel González Núñez
"Art, Esthetics, Ideal": An Ethics For Literary Translators In The Age Of Translating Machines, Gabriel González Núñez
Writing and Language Studies Faculty Publications
The advent of effective machine translation has raised several issues for translators, including the question of how a human translator ought to translate in this age of translating machines. In this context of new ethical questions, the present essay argues that an answer may be found in Pedro Figari’s (1912) philosophical essay on esthetics. Following Figari, the current essay argues that literary translation is art, that as such it can produce an esthetic emotion on readers and that the purpose of such art and esthetics is an ideal in the form of the continuous betterment of the human condition.
From Physical Correlation To Emotional Connection: The Role Of Passive Haptics On Empathy In Virtual Reality, Jemely Robles
From Physical Correlation To Emotional Connection: The Role Of Passive Haptics On Empathy In Virtual Reality, Jemely Robles
Dartmouth College Master’s Theses
Virtual reality is increasingly explored as a tool for cultivating empathy, and haptic feedback as a tool for enhancing immersion. This paper investigates the effects of combining the two. Fifty-two participants experienced a custom-built VR scene in which a character was shown packing up a room. Participants were assigned to either a haptic condition, receiving passive haptic feedback corresponding to the character's actions, or a non-haptic control condition that did not receive any haptic input. Trait empathy was measured beforehand, and state empathy and engagement were measured after the experience. Thematic analysis was conducted on post-study interviews, and headset recordings …
Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske
Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske
Center for Medical Ethics and Health Policy Staff Publications
People living with endometriosis, a disease in which tissue similar to the lining of the uterus grows elsewhere in the body, often experience prolonged diagnostic journeys because of symptom variability, normalisation of period pain and other symptoms, and lack of awareness of the condition. In this article, we analyse the endometriosis diagnostic journey through the lens of epistemic injustice. Drawing on in-depth interviews with 52 people living with endometriosis in the United States, we introduce the concept of diagnostic buck-passing to characterise the phenomenon wherein individuals who seek treatment for their symptoms end up stuck in a cycle of seeing …
Dr. Janice Chism Piano Music Collection - Accession 1744, Janice Chism
Dr. Janice Chism Piano Music Collection - Accession 1744, Janice Chism
Manuscript Collection
The Dr. Janice Chism Piano Music Collection consists of piano sheet music owned and used by Dr. Janice Chism, a distinguished professor of Biology and Anthropology at Winthrop University. The collection reflects Dr. Chism’s personal musical interests and provides insight into popular and classical music performed in domestic and recreational settings during the early to mid-twentieth century.
The collection is composed primarily of individual pieces of piano sheet music dating from approximately 1919 to 1951, with the majority originating in the 1920s, 1930s, and 1940s. Titles include popular show tunes, jazz-influenced standards, patriotic and folk songs, and light classical arrangements. …
Optimizing Poultry Production And Enhancing Egg Nutrient Composition Through Kelp Supplementation In Laying Hens, Meghan Clifford
Optimizing Poultry Production And Enhancing Egg Nutrient Composition Through Kelp Supplementation In Laying Hens, Meghan Clifford
Open Access Dissertations
The development of sustainable feed supplements is a crucial component in addressing the current global need for resilient and environmentally responsible food systems. This dissertation has explored the potential of brown algae (Saccharina latissima) as a sustainable feed supplement for poultry with the potential to benefit production efficiency, product quality, and the global food supply. With both controlled feeding trials and a producer-based survey, the work in this dissertation investigates the nutritional, biological and practical implications of adopting kelp into poultry diets.
Chapter one provides a comprehensive overview of the current literature surrounding the use of marine sources …
Research Initiative For Northeast Grazing Soils (Rings) Soil Carbon Data Report, Karla M. Jarecke, Joseph P. Amsili, Alexandra Contosta, Caitlin Hicks Pries, Kelsey H. Jensen, Morgan Mcclure, Alexander Steiner, Eric Von Wettberg, Mojtaba Zeraatpisheh
Research Initiative For Northeast Grazing Soils (Rings) Soil Carbon Data Report, Karla M. Jarecke, Joseph P. Amsili, Alexandra Contosta, Caitlin Hicks Pries, Kelsey H. Jensen, Morgan Mcclure, Alexander Steiner, Eric Von Wettberg, Mojtaba Zeraatpisheh
Faculty Publications
The Research Initiative for Northeast Grazing Soils (RINGS) is a multi-institutional collaboration with a mission to advance the understanding of soil organic carbon (SOC) dynamics in grazing systems across the northeastern United States. RINGS distributed a survey between October 2025 and June 2026 to researchers and practitioners across the Northeast to identify where SOC data has been collected and the basic field and lab methods used. The survey asked participants to describe existing soil datasets collected on land directly or indirectly impacted by grazing livestock. The survey was distributed to colleagues of RINGS researchers that work at university, corporate and …
Trading Places With The ‘Other’: Octavia Butler’S “Bloodchild” And “Amnesty”, Katie Zamora-Godinez
Trading Places With The ‘Other’: Octavia Butler’S “Bloodchild” And “Amnesty”, Katie Zamora-Godinez
Research Papers
No abstract provided.
A Guide To Human Ecology Mapping: An Approach For Understanding Human-Environment Connections, Thien-Kim Bui, Rebecca J. Mclain, David Banis, Lee Cerveny
A Guide To Human Ecology Mapping: An Approach For Understanding Human-Environment Connections, Thien-Kim Bui, Rebecca J. Mclain, David Banis, Lee Cerveny
Occasional Papers in Geography
Occasional Papers in Geography Publication No. 9
Places matter to people, and maps can help people and communities share why places matter. Over the past 30 years, public participation GIS (PPGIS) and other forms of human ecology mapping (HEM) have become important ways for agencies, non-governmental organizations, environmental and community advocacy groups, university researchers, and others to learn about or advocate for what matters to people about landscapes they visit, use, or love.
HEM is a method for mapping human-environment interactions and connections. This manual is intended for the planner or practitioner who is interested in using HEM to strengthen …
If You Build It, Will They Stay? Fish Communities Continue To Utilize Restored Habitat A Decade Following An Instream Restoration, Alexis L. Vandenberg
If You Build It, Will They Stay? Fish Communities Continue To Utilize Restored Habitat A Decade Following An Instream Restoration, Alexis L. Vandenberg
Masters Theses
Lotic ecosystems are degraded at an alarming rate due to anthropogenic activities. In order to combat these changes, stream restorations are implemented to improve conditions such as water quality, habitat heterogeneity, and bank stability. However, the impacts of these restorations are often understudied and long-term impacts are unknown. Restorations are typically designed to be ‘fish attractors’; this idea is known as the ‘Field of Dreams hypothesis’ – ‘if you build it, they will come’. This study uses data collected in Kickapoo Creek, Coles County from 2009 to 2015 and again in 2021 and 2022 to assess the long-term impacts of …
Compositional And Functional Shifts In Fish Community Structure In Response To Low-Head Dam Removals, Joshua D. Bruegge
Compositional And Functional Shifts In Fish Community Structure In Response To Low-Head Dam Removals, Joshua D. Bruegge
Masters Theses
Low-head dams serve as intermittent barriers to aquatic connectivity and directly alter both upstream and downstream habitats and biotic communities. In 2018 and 2019, two low-head dams in the Vermilion River watershed of eastern Illinois were removed, reconnecting over 1,700 kilometers of upstream habitat within the basin. To determine the impacts of these dam removals, fish community surveys were conducted at 12 fixed sites across three reaches in two rivers from 2012-2022. This study assessed reach-specific temporal responses of the fish community and habitat characteristics. I linked trait expressions within the fish community to abiotic variables using the co-inertia RLQ …
The Role Of International Student Office Directors In Facilitating The Transitional Adjustment Of International Students In U.S Higher Education, Agnes Afi Yigah
The Role Of International Student Office Directors In Facilitating The Transitional Adjustment Of International Students In U.S Higher Education, Agnes Afi Yigah
Masters Theses
This qualitative study explored how International Student Office Directors facilitate the transitional adjustment of international students in U.S. higher education institutions. Guided by Schlossberg’s Transition Theory (1981) and Schlossberg’s Mattering and Marginality Theory (1989), this study examined the challenges international students face, the support strategies implemented by International Student Office Directors, and the institutional factors influencing student adjustment and well-being. International students experience challenges related to housing and logistical adjustment, financial and immigration-related stressors, academic system adjustment and self-advocacy, and social integration and emotional adjustment. Proactive and holistic support approaches, including pre-arrival communication, orientation programs, academic support, emotional support, and …
Latent Classification Of Time-Dependent Transition Rates In Longitudinal Binary Outcome Data, Joonha Chang, Wenyaw Chan
Latent Classification Of Time-Dependent Transition Rates In Longitudinal Binary Outcome Data, Joonha Chang, Wenyaw Chan
Faculty, Staff and Student Publications
Continuous-time Markov chain (CTMC) models and latent classification methods are commonly used to analyze longitudinal categorical outcomes in medical research. While CTMC models are popular for their simplicity and effectiveness, their assumption of constant transition rates presents limitations in capturing dynamic behaviors. To address this, non-homogeneous continuous-time Markov chains (NH-CTMCs) have been developed, incorporating time-varying transition rates to enhance model flexibility. In this study, we leverage closed-form transition probabilities for a fully ergodic two-state NH-CTMC model and propose a latent class clustering approach to identify heterogeneous transition rate patterns within the population. We emphasize the potential advantages of these models …