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Changepoint Analyses Confirms Global Tropical Cyclone Frequency Decline, Michael Wehner, Thomas Fisher, Norou Diawara, Robert Lund

Mathematics & Statistics Faculty Publications

Changes in tropical cyclone frequencies as the climate warms is a topic of significant current debate [1, 2]. There is no accepted theory of how tropical cyclogenesis might respond to a warmer ocean-atmosphere system as multiple controlling factors exist [3–7]. Anthropogenic warming of surface ocean temperatures due to increased greenhouse gas concentrations [8] increases the potential for tropical cyclogenesis [9–11]; however, realized cyclogenesis also requires an initial local disturbance [12–16] to develop. Most multi-decadal tropical cyclone permitting climate models (i.e. resolutions of 15-50km) exhibit frequency decreases in warmer climates, despite the increase in tropical cyclogenesis potential [17–25]. In this paper, …

An Optimization-Driven Approach For Accurate Prediction Of Diabetes Mellitus, H El Bouhissi, Sb Xu, John H Wang

Department of Information Management and Business Analytics Faculty Scholarship and Creative Works

Diabetes mellitus is a progressive metabolic disorder requiring timely identification to prevent severe complications and reduce healthcare burdens. This paper proposes an optimization-driven deep learning framework for accurate diabetes prediction, integrating Long Short-Term Memory selection and hyperparameter tuning. The framework is conceptualized as a decision-support system embedded within electronic health records and clinical workflows, supporting physicians, nurses, case workflow integration, governance, and privacy-are addressed to ensure alignment with real-world organizational contexts. The results demonstrate both technical feasibility and practical relevance, linking predictive analytics capability with human-AI collaboration, adoption factors, and operational decision-making in healthcare organizations.

Investigation Of Genx Exposure To Pathways Associated With Colorectal Cancer Risk, Emily J. Ferguson

Theses and Dissertations--Toxicology and Cancer Biology

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants widely detected in drinking water and food sources, resulting in chronic human exposure. Among these compounds, hexafluoropropylene oxide dimer acid (HFPO-DA), commonly known as GenX, has been introduced as a short-chain replacement for legacy PFAS such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Although GenX is believed to be a safer alternative, emerging research suggests it can still affect human health.

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death in the United States, highlighting the need to better understand environmental …

Uncovering The Mechanism Of Reep2-Mediated Emt-Driven Membrane Trafficking In Lung Adenocarcinoma, Kevin Fulp

Theses and Dissertations--Toxicology and Cancer Biology

Membrane trafficking is frequently disrupted during cancer progression, and the underlying mechanisms remain largely unknown. Currently, no effective drugs target dysregulated membrane trafficking for cancer treatment. Recent evidence has demonstrated that epithelial-to-mesenchymal transition (EMT) in lung adenocarcinoma (LUAD) employs a membrane trafficking program to coordinate cancer cell invasion and immunosuppression. To further dissect the pro-tumorigenic membrane trafficking program, we initiated an in vivo CRISPRi screen to assess more than 2,000 membrane trafficking-related genes in a syngeneic mouse LUAD model. We identified REEP2, an endoplasmic reticulum (ER) shaping protein, as a novel regulator of EMT-driven membrane trafficking. High REEP2 expression is …

Reep2-Driven Pro-Metastatic Secretion Promotes Lung Cancer Progression, Oluwafunminiyi E. Obaleye

Theses and Dissertations--Toxicology and Cancer Biology

Membrane trafficking plays a critical role in cellular function and is frequently dysregulated in cancer to promote metastasis. In lung adenocarcinoma (LUAD), the epithelial-to-mesenchymal transition (EMT) activating transcription factor, ZEB1, drives a pro-metastatic membrane trafficking program; however, the underlying molecular mechanisms remain poorly understood. Using a CRISPR interference (CRISPRi) in vivo screen of 2,099 membrane trafficking regulators in a syngeneic mouse model of EMT-driven LUAD, we identified REEP2 — an endoplasmic reticulum (ER) shaping protein — as a critical regulator of tumor progression. REEP2 mRNA expression correlates with poor prognosis, EMT signatures, and an immunosuppressive tumor microenvironment in LUAD patients. …

2026 Lynn University Student Research Symposium, Lynn University

Student Research Symposium Programs

The 2026 Lynn University Student Research Symposium was held Friday, April 24, 2026 on the 2nd floor of the Eugene M. and Christine E. Lynn Library.

Puberty Blockers And Classifications On The Basis Of Sex, Mark Strasser

Western New England Law Review

For the last half-century, the Court has recognized that discrimination on the basis of sex triggers equal protection guarantees. Those guarantees impose a heavy–but by no means insurmountable–burden on the State to justify its use of sex-based classifications. Recently, in United States v. Skrmetti, the Court refused to apply heightened scrutiny to a sex-based classification in a shocking opinion that bodes poorly form equal protection in particular and constitutional analysis as a general matter.

Granting The High Seas Personhood And Quasi-State Status, Jennifer Bass

Western New England Law Review

The Agreement on Marine Biological Diversity of Areas Beyond National Jurisdiction has now secured sufficient ratifications to enter into force. The enforcement mechanisms of the treaty could be strengthened to better protect biodiversity by granting the high seas personhood and providing the high seas quasi-statehood. The enforcement mechanism would be through the United Nations Convention on the Law of the Sea’s (UNCLOS) International Tribunal of the Sea. Specifically, enforcement could be strengthened by working with other entities such as Regional Fisheries Management Organizations (RFMOs), the Fish Stocks Agreement, and the Convention on International Trade in Endangered Species of Wild Fauna …

31p Solution Nmr Investigation Of Abasic Dna, Clarissa R. Krimmel

Graduate Theses/Dissertations

Base excision repair (BER) mechanisms fix single base lesions in DNA, such as T:G mismatches. During the base excision repair mechanism, an abasic site (AP site) is formed as an intermediate. AP sites are unstable and highly mutagenic; they can stop DNA replication. This research investigates how the conformational properties of abasic sites in DNA affect the binding recognition of enzymes involved in DNA repair mechanisms, including BER. Three different abasic sequences are being analyzed for this research project. A second project looks at the effects of a naturally occurring purine derivative, hypoxanthine, on the DNA backbone. These hypoxanthine lesions …

Corpus Meum, Mea Electio, Kara L. Coonrod

Graduate Theses/Dissertations

The right to bodily autonomy and reproductive freedom is something I hold very close to my heart. Women who did not wish to embrace motherhood, or who grew beyond the walls of the hearth and home, have been far more often persecuted than praised. Over the past two years, I have created artwork borrowing the visual and material language of the Catholic church (along with personally relevant folklore) to elevate my freedom of choice and bodily autonomy in the face of religiously driven political oppression. Using a less frequently referenced organ from my reproductive system to represent my struggle against …

Remediation Impacts Metal Concentrations And Metal Tolerant Bacteria In Soils Of The Missouri Tri-State Mining District, Ophelia R. Pettington

Graduate Theses/Dissertations

After over 100 years of Zn and Pb mining in the Tri-State mining district (TSMD), former mines continue to be sources of metals. Metal contaminated soils can be remediated using plant-microbe interactions. Plants manipulate their microbiome and recruit microbes to increase metal tolerance. Remediating bacteria are site-specific and identifying native microbes can accelerate remediation efforts. Studies relating microbes and metal concentrations in remediated areas in the TSMD are scarce. I collected root and bulk zone soils associated with Andropogon virginicus from remediated and non-remediated sites in Webb City, MO. I used 16S rRNA gene amplicon sequencing to evaluate the bacterial …

Investigating The Effects Of Biodegradable And Non-Biodegradable Microplastics On Pea Plant (Pisum Sativum L.), Blessing Bisola Akinwande

Graduate Theses/Dissertations

Microplastics have emerged as a significant environmental concern, particularly in agricultural soils where they can interact with plants and potentially affect crop productivity and quality. This study investigated the effects of biodegradable and non-biodegradable microplastics on the growth, physiology, and elemental and metabolite composition of Pisum sativum L. (pea plants). Plants were cultivated under greenhouse conditions and exposed to 2% (w/w) compostable bioplastic (CBP) as a biodegradable microplastic and high-density polyethylene (HDPE) as a non-biodegradable microplastic. Plant growth and physiological parameters, including plant height, seed biomass, chlorophyll content, and lipid peroxidation, showed no significant differences between treatments and control, …

Lsu General Catalog 2026-2027, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students

Improving Human Dimensions Of Conservation Planning: Challenges And Opportunities For Sustainable Conservation Outcomes, Vivian Hulugh

Electronic Theses and Dissertations

Conservation planning is important to ensure both ecological and social benefits of natural resources, including the maintenance of functional ecosystems and stable wildlife populations as well as the provision of resources that communities rely on. Yet, the integration of the human dimensions of conservation planning remains limited in practice. This thesis examines conservation planning in South Dakota and within Joint Venture (JV) partnerships, using qualitative methods to identify challenges and opportunities for more effective and coordinated planning. In chapter one, I examine how collaboration, public participation, and the use of climate information are integrated conservation planning in South Dakota and …

Transcriptomic And Epigenetic Analysis Of Dormant Grape Buds During Chilling Fulfillment, Imasha Thilakarathna

Electronic Theses and Dissertations

No abstract provided.

Production, Characterization, And Diagnostic Application Of Monoclonal Antibodies Against The N-Protein Of Avian Metapneumovirus Subgroup B, Ravi Gupta

Electronic Theses and Dissertations

Avian metapneumovirus (aMPV) is a respiratory pathogen that causes Turkey Rhinotracheitis (TRT) in turkeys and Swollen Head Syndrome (SHS) in chickens. The infection leads to facial swelling, nasal discharge, reduced egg production, and poor growth. This virus is classified into four subgroups: aMPV-A, B, C, and D, with two other novel subgroups, in which aMPV-A, B, and C are most prevalent in the commercial flocks. In early 2024, aMPV-A and B outbreaks have been reported in the US, resulting in severe economic losses. An economic assessment estimates around $112 million in losses in Minnesota and up to $434 million in …

The Fertilization President: A Rhetorical Analysis Of The United States’ Rebirth Of Pronatalism, Kara Vetch

Electronic Theses and Dissertations

The United States experienced one of the lowest birth rates in decades in 2024 and has been blamed by policymakers for poor economic and societal outcomes. To combat this, President Donald Trump signed an executive order to encourage healthcare insurances to lower the cost of fertility treatments. Policies encouraging more births align with pronatalist ideologies, the belief that higher national birth rates are better for society. Furthermore, Vice President JD Vance and social media influencers, Malcolm and Simone Collins, have built a strong resurgence of pronatalist ideologies through public addresses and interviews long before Trump’s executive order. For an in-depth …

Computational Modeling Of Biophysical Transport: Respiratory Drug Delivery And Tissue-Level Physics, Md Tariqul Hossain

Electronic Theses and Dissertations

The nasopharynx, the upper part of the pharynx located at the back of the nose serves as a critical hotspot for initial respiratory infections via inhaled transmission, largely due to the presence of specific surface receptors that pathogens can exploit for cell invasion, combined with a relatively sparse local mucociliary substrate. To enhance the therapeutic efficacy against certain pathogens, such as the SARS and Influenza viruses, it is therefore essential to improve the targeted delivery of drugs to the nasopharynx. This study explores the use of intranasal sprays as a method for drug administration and models the transport of sprayed …

Strong Foundations: Supporting Mental Well-Being In School-Age Youth, Skylar Simpson

Occupational Therapy | OTD Capstone Projects

School-age youth in the United States increasingly face stressors that disrupt their overall mental well-being, highlighting a need for accessible preventative interventions. To address this gap, this doctoral capstone project developed a program titled Strong Foundations: Supporting Mental Well-Being in School-Age Youth, an evidence- and occupation-based program consisting of various interventions designed to enhance the well-being of youth attending a San Francisco Recreation and Park (SFRPD) community-based summer camp. Through embedding occupational therapy-based programming into an environment that currently lacks dedicated mental well-being promotion methods, the Strong Foundations aims to foster mental well-being among school-age youth through occupational engagement that …

Promoting Postpartum Maternal Self-Efficacy Through Prenatal Pelvic Floor Health And Sensory Modulation Education, Cate Smith

Occupational Therapy | OTD Capstone Projects

Pelvic floor therapy, also called pelvic floor health care, is an emerging field for occupational therapy practitioners. Pelvic floor dysfunction (PFD) is a common health outcome after pregnancy and childbirth. Although most women receive consistent prenatal health care, they do not receive the education they need to manage symptoms of PFD such as incontinence, pain, and sensory dysregulation during the postpartum period. Occupational therapy can play a meaningful role in educating and supporting women during the prenatal period, postpartum healing, and role acquisition. This doctoral capstone project researched educational strategies to improve self-efficacy among perinatal women. Albert Bandura defines self-efficacy …

Exploring The Role Of Pleasure In Cognitive Tasks, Nafisa Kazi Iqbal

Dissertations and Theses

The present study investigates whether the experience of a pleasant-valenced physical stimulus will positively influence performance on a cognitive task. The concept of hedonics is explored as hedonic responses, emotional reactions to stimuli involving feelings of pleasure and displeasure, play a crucial role in various psychological processes. There is a limited amount of literature regarding pleasant smell and its impact on the performance of cognitive tasks. The reported study addresses this limitation by comparing Stroop task performance of participants in two conditions, pleasant scent and neutral scent. These findings add to our understanding of the impact of pleasant smell on …

Virginia Commonwealth University Courses (2026), Virginia Commonwealth University

VCU Bulletins

Listing of courses for the 2026-2027 year.

Virginia Commonwealth University Undergraduate Bulletin (2026), Virginia Commonwealth University

VCU Bulletins

Undergraduate bulletin for Virginia Commonwealth University for the academic year 2026-2027. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for undergraduate programs

Virginia Commonwealth University Graduate Bulletin (2026), Virginia Commonwealth University

VCU Bulletins

Listing of courses for the 2026-2027 year.

Evaluating The Impact Of Telemedicine-Based Medication Education On Glycemic Control In Adult Male Veterans With Type 2 Diabetes Mellitus, Megan N. Calter

West Chester University Graduate Theses, Dissertations, and Final Projects

Veterans experience disproportionately high rates of type 2 diabetes mellitus (20.5% vs 11.6% nationally), driven by military-related factors such as PTSD, deployment-related obesity, and service-connected disabilities. At a large urban primary care clinic, 28% (40/141) of veterans with type 2 diabetes mellitus had persistently elevated HbA1c levels of ≥8%, indicating a high risk for diabetes-related complications. This quality improvement project aimed to reduce the proportion of veterans with HbA1c of ≥8% by implementing tailored telemedicine-based medication education, leveraging underutilized virtual care infrastructure to address access barriers and improve diabetes self-management. Participants received two 30-minute telemedicine medication and disease management education …

Nurse-Facilitated Cbt-I Using The Cbt-I Coach Free Application, David Berhanu Mr.

West Chester University Graduate Theses, Dissertations, and Final Projects

Chronic insomnia is a prevalent condition associated with significant physical, psychological, and functional impairment. Although Cognitive Behavioral Therapy for Insomnia (CBT-I) is recommended as first-line treatment, access remains limited, resulting in continued reliance on pharmacologic therapies. This DNP project evaluated the effectiveness of a nurse practitioner (NP)-facilitated CBT-I program, supported by the CBT-I Coach, in improving sleep outcomes and reducing reliance on sleep medications among adults with chronic insomnia in an outpatient setting. Methods: A pre–post intervention design was utilized. Adult participants with chronic insomnia were enrolled in a structured CBT-I program consisting of an initial 60-minute intake session followed …

A Community Cultural Wealth Approach In Exploring The Lived Experiences Of Second-Generation Black Caribbean American Undergraduate Women Attending U.S. Predominantly White Higher Education Institutions, Arielle Phillips-Law

West Chester University Graduate Theses, Dissertations, and Final Projects

This qualitative phenomenological study explores the lived experiences of second-generation Black Caribbean American women undergraduate students who attend U.S. predominantly white institutions. Black women students from ethnic minorities encounter racism, sexism, and ethnocentrism, all factors that can influence their persistence and completion within U.S. higher education and the economic outcomes post-graduation. Using Community Cultural Wealth as the guiding theoretical framework for this study, I focused on centering the strengths and skills of Black Caribbean women in their navigation of higher education. I used an interpretive phenomenological analysis as the study methodology. Participants included ten second-generation Black Caribbean cisgender women who …

Stories Of Strength, Struggle, And Unchecked Boxes: An Intersectional And Mestiza Consciousness Study Of Testimonios From Latina College Students, Stephanie Pinel

West Chester University Graduate Theses, Dissertations, and Final Projects

Latina college students remain the fastest-growing student population within the United States higher education system. However, when discussing the Latina identity, monolithic assumptions remain at the forefront. When faced with systems of oppression, Latinas experience intersectional struggles that ultimately render their college experiences invisible. Using the theoretical frameworks of Mestiza Consciousness (Anzaldúa, 2021) and Intersectionality (Crenshaw, 1989) this testimonio-qualitative study explored how Latina college students made sense of their racial/ethnic identity and the intersectional forces that then shaped their testimonios of strength and struggle within higher education. I interviewed eleven Latina-identifying students utilizing a testimonio method and analyzed the data …

Examining The Flow State In College Football, Nicholas R. Reynolds Jr., Selen Razon

West Chester University Graduate Theses, Dissertations, and Final Projects

The flow state, first defined by Csikszentmihalyi (1990) as a state of total absorption in an activity characterized by effortless control, heightened focus, and peak functioning, has been well-documented in sport but has received limited attention in the context of college football. This study examined the flow state experiences of varsity football players at West Chester University, including their awareness of the concept, the frequency and subjective nature of their experiences, the strategies they use to reach this state, and their perceptions of its relationship to team success. A researcher-developed survey was administered to team members during the offseason, yielding …

School-Based Mental And Emotional Support For Urban Students Experiencing Traumatic Loss, Britney Daniel-Harris

West Chester University Graduate Theses, Dissertations, and Final Projects

This study explores the perception of educational staff members on school-based mental and emotional resources for urban students experiencing traumatic loss. With increased levels of research centered on enhancing training protocols to educate teachers on identifying, supporting, and guiding traumatic care through evidence-based resources, there is an opportunity to understand their experiences by hearing their voices through a narrative inquiry qualitative research design. The Substance Abuse and Mental Health Services Administration (SAMHSA) has six principles of a trauma-informed environment, which were utilized to analyze participant stories. Five teachers, one social worker, and one special education leader participated in one-on-one interviews …