Digital Commons Network^™

Contributions Of Arginine And Nitrosative Stress To Huntington’S Disease Progression, Ian D. Gaudet

Electronic Theses and Dissertations

Neuroinflammation is a well-established component of Huntington's disease (HD) pathogenesis, yet the intricate molecular mechanisms that govern this process remain a topic of ongoing research and debate. This dissertation elucidates a novel pathway linking arginine metabolism and nitrosative stress to core HD pathology. We found that the arginine transporter SLC7A2 is selectively upregulated in various HD cellular models and patient samples. Our findings reveal that this upregulation drives an overactive inflammatory response, leading to abnormally high inducible nitric oxide synthase (iNOS) induction and subsequent nitric oxide (NO) production, which causes excessive protein nitrosylation and an increase in mitochondrial fragmentation.

To …

Coping With Adversity: Exploring The Role Of Protective Factors And Their Impact On School Enrollment And Satisfaction Among Adolescents Living With Hiv In Low-Resource Settings, Jennifer Nattabi

Brown School Graduate Student Theses and Dissertations

Globally, an estimated 2.38 million children and adolescents (0–19 years) are living with HIV, with 80% residing in sub-Saharan Africa. In Uganda, adolescents remain at high risk, with approximately 6,600 new infections among 10–19-year-olds in 2023. Despite expanded access to antiretroviral therapy (ART), adolescents Living with HIV (ALHIV) continue to experience poor outcomes, including low viral suppression and high mortality, largely driven by non-adherence. However, ART adherence represents only one dimension of their lived experience. ALHIV must also navigate intersecting adversities, including poverty, stigma, orphanhood, and exposure to sexual and gender-based violence, while meeting academic expectations, particularly in boarding school …

Sex-Aware Causal Inference Assessment Of The Immune System In Complex Neurodegenerative Diseases, Frida Lona-Durazo, Ross P Byrne, Marc-Olivier Pilon, Michael D Greicius, Marie-Pierre Dubé, Michael E Belloy, Russell L Mclaughlin, Sarah A Gagliano Taliun

2020-Current year OA Pubs

Sex differences, in terms of prevalence, symptoms and disease progression, are established in the aetiology of complex neurodegenerative diseases, including amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease, but the underlying biology driving these differences remains poorly understood. There is emerging evidence from genetic and functional analyses affirming the role of the immune system in such diseases, but a thorough assessment of sex differences in the link between the immune system and neurodegenerative diseases remains lacking. Here, we applied a robust causal inference approach, two-sample Mendelian randomization, to evaluate the causal effect of immune-related protein levels on three neurodegenerative diseases …

Bdelloid Rotifers Harbor A Voltage-Gated Proton Channel With Distinct Mechanistic Features, Liang Yan, Chiara Boschetti, Liang Hong

School of Biological and Marine Sciences

Bdelloid rotifers are renowned for their extraordinary resilience. They can survive desiccation and long-term freezing and revive once favorable conditions return. Such remarkable survival abilities suggest that the evolution of specialized molecular adaptations sustain pH homeostasis under extreme environmental stress. In the present study, we identify and functionally characterize an isoform of the voltage-gated proton channel (Hv) from the bdelloid rotifer Adineta ricciae, which we name ArHv2. Unlike its paralog ArHv1 and human Hv1 that activate only at positive membrane potentials and contribute modestly to proton extrusion under normal conditions, the ArHv2 activates even at negative potentials, enabling rapid and …

Integrating Oncology Into Entry-Level Physical Therapist Curricula, Shana Harrington, Christopher M. Wilson, Morgan Zaranec, Lori Boright

Oncology Rehabilitation in Practice

Print issue available for $25.

Background: Cancer and its treatments commonly result in adverse effects that impair function, well-being, and quality of life, necessitating access to skilled physical therapists (PTs). Although oncology is an essential component of physical therapist practice, entry-level education in cancer rehabilitation has historically been limited. In 2025, the Essential Competencies for Physical Therapy Entry-Level Education in Oncology were developed through a mixed-methods, modified Delphi process, establishing 19 competencies across six domains and defining minimum expectations for new graduates. To support translation of these competencies into academic curricula, a practical implementation resource was needed.

Purpose: To …

Teaching China Beyond Eurocentrism: Intercultural Pedagogy And The Case Of The República Del Reino De La China By Jerónimo Román Zamora, Miriam Diaz Belizon

Comparative Philosophy

Interdisciplinary approaches to teaching China in Western academic contexts often reproduce Eurocentric frameworks that reduce Chinese philosophical and cultural traditions to subordinate objects of analysis. This article proposes an alternative model grounded in intercultural philosophy and the Filosofías del Sur, arguing that China should be approached not as a distant object of representation, but as an epistemic interlocutor capable of transforming philosophical education. The article develops this argument through the recovery of the República del Reino de la China, included in the 1595 edition of Repúblicas del Mundo, as a key example of early intercultural mediation from the European South. …

Intercultural Questioning: Teaching Report On A Question-Oriented Pedagogy In Teaching Chinese Philosophy, Sai Hang Kwok

Comparative Philosophy

Language and cultural barriers pose major obstacles to teaching Chinese philosophy to Western philosophy students. Without a cultural and linguistic background, students often struggle to read the original Chinese philosophical texts. Translation also involves issues of interpretation that are difficult to be settled in undergraduate-level courses. To address this situation, this paper introduces a question-oriented pedagogy called “intercultural questioning”. Instead of aiming at a comprehensive understanding of the entire Chinese philosophical tradition, the question-oriented pedagogy reveals the implicit assumptions in one’s conceptual frameworks and unexamined questions in Western philosophy through the East-West dialogue. Students can obtain philosophical insights from Chinese …

Why Minds Need Bodies: Organismic Unity And Limits Of Artificial Consciousness, Renée Snow

Comparative Philosophy

This paper argues that functional organization alone is not sufficient for phenomenal consciousness or the existence of a unified subject of experience. While many contemporary accounts of artificial consciousness assume that replicating the causal or computational structure of the brain would be sufficient for subjective experience, this paper identifies a deeper constraint: consciousness depends on organismic unity. The argument proceeds through a triangulation of conceptual, empirical, and metaphysical considerations. First, Zuboff’s thought experiment shows that functional organization can be preserved while the unity of the subject dissolves, suggesting that causal pattern replication alone cannot secure subjectivity. Second, findings from neuroscience …

A Poetic Call For And A Reflection And Commentary On Clarity, Understanding, Hope, Courage, And Compassion, Carroy U. Ferguson

Psychology Faculty Publication Series

Finding a published poem I had written as a teenager, titled “The Heavens Weep.” this article uses that poem as the basis for a commentary that reflects on the state of the world today (2026),  As a commentary, the article uses the poetic and metaphoric words in the poem as a relevant "reality check" for what is still going on today.  In essence, the commentary is about a call for Clarity, Understanding, Hope, Courage, and Compassion, or what I call Archetypal Energies, Higher Vibrational Energies that operate deep within our individual and collective psyches to creatively urge us to "see" …

Leventhal, Alan, San Jose State University

Emeritus and Retired Faculty Biographies

San Jose State University, Anthropology, MA 1993

(MA Thesis Title: A Reinterpretation of Some San Francisco Bay Mound Sites: A View from the Mortuary Complex from Prehistoric Site CA-ALA-329, The Ryan Mound): https://scholarworks.sjsu.edu/etd_theses/694/

City College of New York, Major: Anthropology; Minor: Education and Geology, BA 1973

Archaeological Field Schools

University of Nevada: Nevada State Museum Archaeological Field School, Dr. Robert Elston, Director, June - August 1972

City College of New York Archaeological Field School, Dr. Robert Schuyler, Director, June - August 1971

See CV for Awards/Scholarships, 1972-2013.

The Aste-Bgc Data-Assimilative Regional Ocean Biogeochemical Model, L. A. Moseley, G. A. Mckinley, D. Carroll, D. Menemenlis, R. Dussin, A. T. Nguyen

Faculty Research, Scholarly, and Creative Activity

We present a data-assimilative regional ocean biogeochemical model, ASTE-BGC, which simulates the physical and biogeochemical state of the North Atlantic Ocean from 2002 to 2017. Model physics are provided by a physical state estimate (ASTE), which assimilates O(10⁹) in situ and satellite-based observations over the model domain and time period. Model biogeochemistry is simulated by a medium-complexity biogeochemical module (BLING), which simulates nine prognostic biogeochemical tracers and three ecological classes. Through a three-step optimization process which combines informal adjustments and formal mathematical optimization, we minimize model-data misfit between a “spun-up” simulated biogeochemical state and O(10⁵) BGC-Argo …

Formalization Of Nomenclatural Acts Proposed In Tang (2026) (Scorpiones: Buthidae, Chaerilidae, Scorpiopidae), Victoria Tang

Euscorpius

Several nomenclatural, taxonomic, and faunistic decisions put forth in Tang (2026) are formalized herein: (1) four nomina dubia, Chaerilus tessellatus Qi et al., 2005, Scorpiops langxian Qi et al., 2005, S. pococki Qi et al., 2005, and Isometrus (Reddyanus) wenjieae Huang et al., 2025; (2) two junior subjective synonyms, Scorpiops langxian = S. pococki = S. tibetanus Hirst, 1911 syn. n.; (3) one new “aspidonym”, Scorpiops obluda Tang, 2026 sp. indet. nomen nudum; and (4) removal of Scorpiops hardwickii (Gervais, 1843) and S. petersii Pocock, 1893 from the Chinese scorpiofauna. Reddyanus tibetanus (Lourenço & Zhu, 2008) is maintained …

Our Honors Impact: Evidence Of Honors Student Experience And Outcomes, 01 - The Initial Evidence Review, Brian Hoey, Honors College

Publications of the Honors College at Marshall University

Our Honors Impact, 01: Evidence of Honors Student Experience and Outcomes presents an initial review of student-centered evidence collected by the Honors College at Marshall University through its developing Honors Impact Evidence Bank. Drawing on student reflections, supported-project deliverables, program assessments, profiles, and other documented experiences, the report examines how honors education is experienced in practice and what becomes possible through integrative and experiential learning, mentorship, peer connection, financial support, global engagement, and opportunities for independent inquiry. Student narratives illustrate recurring patterns of intellectual growth, confidence, belonging, professional development, and connection to Appalachia and West Virginia. As the first edition …

Comparing Online Versus In-Person Administration Of Cognitive Tasks And Evaluating Their Predictive Utility Of Inattention Symptoms And Related Behaviors, Cameron Pothoven

Master's Theses

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder associated with less developed working memory (WM) processes, theorized to be a core contributing factor in the development of ADHD and a predictor of ADHD symptom severity (Alderson et al., 2013; Rapport et al., 2008). Objective measures inclusive of working memory tasks, when used in conjunction with self-report measures, have been previously shown to increase the accuracy of diagnosing ADHD (Marshal et al., 2021. However, given that WM is typically assessed by a trained clinician, it is unclear how accurate and comparable online administration of adapted WM tasks are to their in-person counterparts. …

Blue Crab Reproductive Output And Phenology In A Changing Climate, Blaise Rohan

Master's Theses

Globally, ecosystems are experiencing rising temperatures due to climate change, with potential consequences for reproductive investment and timing in many species. Blue crabs, Callinectes sapidus, support valuable commercial fisheries throughout the U.S. Atlantic and Gulf coasts, and understanding variation in reproductive output has important management and conservation implications. This study examined two components of blue crab reproduction: (1) reproductive investment across populations spanning multiple latitudes (New York, New Jersey, North Carolina, Mississippi, and Texas), using a space-for-time substitution to assess the effects of varying thermal regimes on fecundity and egg quality, and (2) spawning phenology in North Carolina from …

Standardized Training Methodologies For Medical Laboratory Science Students And Their Importance For Student Success, Maria Simpson

Medical Laboratory Science Independent Study Projects

Clinical education is a critical component of Medical Laboratory Science (MLS) programs, serving as the primary bridge between academic instruction and professional practice. However, traditional clinical rotation training models often struggle to keep pace with rapid advancements in laboratory technology, expanding professional responsibilities, workforce shortages, and heightened patient safety expectations. The purpose of this capstone project is to examine the key factors driving the need to update training methodologies in MLS clinical rotations and to evaluate contemporary educational approaches that better prepare students for entry-level practice. This project addresses systemic challenges faced by clinical laboratories, such as staffing constraints, heavy …

Data Centers Face Volatile Regulatory Landscape, Michael B. Gerrard

Sabin Center for Climate Change Law

The construction of new data centers for artificial intelligence has become a major engine of the U.S. economy. More than 700 data centers are now under construction across 40 states, with many more to come.

These are typically multi-billion-dollar projects. This boom is facing growing public opposition, which has led to an extremely volatile regulatory land-scape, especially at the state and local levels. That landscape is the subject of this article. This volatility has raised the cost of capital for data centers and led to the cancellation of many, and to heightened due diligence by lenders and others.

Nurse Manager Perceptions Of Strategies To Overcome The Underutilization Of Nonpharmacological Pain Control Methods In Adult Acute Care, Landen M. Bonnell

Undergraduate Honors Theses

A basic patient right is to have pain adequately managed. However, research consistently indicates that many adult patients in acute care experience inadequately managed pain, which may contribute to adverse patient outcomes. Studies have shown that nonpharmacological pain management can lead to increased patient satisfaction, shorter hospital stays, and better patient outcomes. However, many barriers exist to nurses providing effective nonpharmacological pain control therapy, primarily including heavy workload and a lack of education and support. Currently, there is insufficient research on how to overcome these barriers. Four nurse managers with experience in nursing leadership were interviewed using a qualitative descriptive …

Online Group Neurobehavioral Therapy (Nbt) For Veterans With Epilepsy And Major Depressive Disorder (Mdd), Melissa F. Fadipe

Dissertations and Theses (Open Access)

Background: Veterans with epilepsy experience high rates of psychiatric comorbidity, most commonly major depressive disorder (MDD). Barriers to accessing mental health care—including geographic distance, transportation limitations related to seizure-related driving restrictions, and fragmented care between neurology and psychiatry, contribute to the underdiagnosis and undertreatment of MDD in this population. Neurobehavioral Therapy (NBT), a Cognitive Behavioral Therapy (CBT)-informed psychotherapy developed for individuals with seizures, has demonstrated benefits for psychological distress and quality of life. Internet-based interventions and short message service (SMS) text messaging offer promising strategies to address access barriers; however, limited research has examined the feasibility and acceptability of delivering …

Baseline Nutrition Knowledge And Feasibility Of A Whatsapp-Delivered Nutrition Education Intervention Among California Wildland-Urban Interface Firefighters, Lauren E. Anderson

Master's Theses

Wildland firefighters perform physically demanding work under challenging environmental conditions that place substantial demands on nutritional health and occupational performance. Despite the importance of nutrition in supporting physical performance, recovery, and long-term health, limited research has examined nutrition knowledge and dietary behaviors among California wildland firefighters or evaluated the feasibility of remotely delivered nutrition education interventions within this occupational population. Therefore, the purpose of this pilot study was to assess baseline nutrition knowledge, nutrition self-efficacy, and dietary behaviors while evaluating the feasibility of a 12-week WhatsApp-delivered nutrition education intervention among California wildland firefighters.

Twenty-four firefighters completed the baseline assessment and …

Mir155, Triplicated In Down Syndrome, Regulates The Development Of Neural Stem Cells And Gabaergic Interneurons In Alzheimer's Disease Mouse And Human Ipsc Models., Xiaodong Zhu, Jean-Vianney Haure-Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al-Subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E Ehrlich

Faculty Research 2026

INTRODUCTION: Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown.

METHODS: We utilized in silico analyses of published databases, MIR155-deleted and -overexpressing human induced pluripotent stem cell (hiPSC)-derived cells, cortical organoids, and amyloid beta precursor protein (APP)/PS1-miR155 knockout mouse.

RESULTS: MIR155HG (miR155 host gene) colocalizes with APP in a neuron-specific, topologically associated domain (TAD) in chromosome 21. In human neural stem cells (NSCs), neurons, and cortical organoids, MIR155 deletion enhanced NSC proliferation and GABAergic interneuron generation. MIR155 overexpression inhibited NSC marker expression …

The Past, The Present, And The Future Of Preclinical Mouse Models For Alzheimer's Disease And Related Dementias., Adrian L Oblak, Michael Sasner, Gregory W. Carter, Gareth R Howell, Stacey J Sukoff Rizzo, Karina Leal, Paul R Territo, Bruce T Lamb

Faculty Research 2026

Over the past decade, the Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease (MODEL-AD) consortium has transformed preclinical Alzheimer's disease (AD) research by addressing critical limitations in traditional mouse models that failed to translate to human disease. By leveraging human genetic discoveries, MODEL-AD has developed > 70 genetically informed mouse models, standardized phenotyping pipelines, and an open-access data infrastructure aligned with late-onset AD biology. These models incorporate human risk variants, environmental factors, and aging to better capture disease complexity, including emerging recognition of mixed pathologies such as vascular contributions, Lewy body disease, and TDP-43 proteinopathy. Despite substantial progress, key challenges …

Stromal Cell Senescence Augments Haematopoietic Cell Fitness In Clonal Haematopoiesis., Jayna J Mistry, Kira Young, Anna Navarro Figueredo, Gibran Edun, Alicia G Aguilar-Navarro, Patricia A Colom Díaz, Maria Telpoukhovskaia, Inés Fernández Maestre, Sheng F Cai, Katharina S Götze, Anastasia N Tikhonova, Ross L Levine, Jennifer J. Trowbridge

Faculty Research 2026

Microenvironment remodelling impacts tumour growth and metastasis, but whether remodelling promotes pre-malignant clonal fitness remains unknown. Here, using single-cell RNA-sequencing of the bone-marrow microenvironment in a mouse model of DNMT3A-mutant clonal haematopoiesis (CH), we identify mesenchymal stromal cells (MSCs) in a molecular state of cellular senescence. Elevated bone-marrow MSC senescence is also observed in humans with CH driven by several common somatic mutations. MSC senescence is induced by mutant haematopoietic cells in a contact-independent manner through production of soluble factors including TNF-α and IL-6. These cytokines activate a Stat3-driven pathway that is necessary and sufficient for MSC senescence induction. Genetic …

A Collaborative Framework For Uncovering Molecular And Cellular Drivers Of Vcid: Foundations For Future Interventions In Dementia., M Luisa Iruela-Arispe, Jason D Hinman, Andrew C Yang, Fabrice Dabertrand, Jin-Moo Lee, Gareth R Howell, The Vcid Centers Without Walls Network

Faculty Research 2026

Vascular-related factors are now considered major contributors to most forms of dementia, including Alzheimer's disease. However, the degree to which vascular deficits contribute to risk, onset, and progression of cognitive impairment and dementia has only recently been appreciated. Our understanding of the mechanisms by which vascular deficits drive cognitive decline in dementia is still limited. Further, the testing of therapeutic approaches to prevent vascular deficits to treat dementia are few. These factors motivated the establishment of the Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center Without Walls (CWOW) network, comprising institutes across the United States. We describe the current …

Worldwide Innovative Network Consortium: Building A Common Global Cancer Database., Farhood Farahnak, Wafik S El-Deiry, Yves A Lussier, Razelle Kurzrock, Shai Magidi, Catherine Bresson, Shirin A Enger, Jia Liu, Jair Bar, Jeremy L Warner, Tobias Meissner, Eitan Rubin, Jens Rueter, Himabindu Gaddipati, Mandar Kulkarni, Zhen Chen, Sewanti Limaye, Rachel Elsey, Brenda M Rubenstein, Anthony M Joshua, Humaid O Al-Shamsi, Khaled M Musallam, Fanny Wunder, Jacques Raynaud, Guy Berchem, Manon Gantenbein, Amal Al Omari, Said Dermime, Hikmat Abdel-Razeq, Pierre Saintigny, Andrés Cervantes, Roger R Reddel, Adel T Aref, Juan Martin-Liberal, Conxi Lázaro, David Cordero Romera, Marina Sekacheva, Raanan Berger, C S Pramesh, Ioana Berindan-Neagoe, Eugenia Girda, Alejandro Piris-Gimenez, Carol J Farhangfar, Mohammed E Salem, Rodrigo Dienstmann, Ramon Salazar, Naftali Z Frankel, Zachary Batist, Yuri Quintana, Gerald Batist

Faculty Research 2026

This review shares the ongoing work of the global Worldwide Innovative Network (WIN) Consortium for Precision Medicine to synthesize emerging cancer treatment data and to define the requirements for a common global cancer database that can truly support precision oncology. We performed a narrative review of emerging cancer treatment data, molecular profiling technologies, and existing clinicogenomic databases, focusing on how tumors are characterized, how subgroups are defined, and how demographic, lifestyle, and environmental factors are captured. The growth in molecular profiling technologies and the development of new targeted therapies are transforming cancer care. Tumors, regardless of tissue origin, are increasingly …

Inhibition Of Moesin And Cd44 In Stem Cell-Derived Neurons Affects The Pathological Genetic Signature Associated With Alzheimer's Disease., Eiden H Brewer, Charles A Williams, Gregory Cary, Ranjita Betarbet, Inez K A Pranoto, Elizabeth L Zoeller, Haian Fu, Allan I Levey, Jesse C Wiley, Gregory W. Carter, Jessica E Young, Treat-Ad Consortium

Faculty Research 2026

INTRODUCTION: Post mortem proteomic analysis of Alzheimer's disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced pluripotent stem cells (hiPSCs)-derived neurons, we assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.

METHODS: Knockdown of MSN and CD44 in hiPSC-derived neurons was performed using short hairpin RNA (shRNA). Amyloid precursor protein processing and intracellular tau phosphorylation was measured using chemiluminescent ELISA assays. Global gene expression was analyzed by bulk RNA sequencing (RNA-seq).

RESULTS: Knockdown …

Educator Experiences Of Schoolwide Pbis Discipline Implementation: Exploring School Culture In Private Pk–12 Schools, Jessica L. Guarneri

Electronic Theses and Dissertations

The purpose of this phenomenological study was to explore educators’ lived experiences implementing schoolwide Positive Behavioral Interventions and Supports (PBIS) discipline systems and to understand how those experiences influenced school culture in private PK–12 schools. Historically, PBIS focused on specific outcomes, such as reductions in discipline referrals, suspensions, and behavioral incidents. Though these indicators are critical, they do not consider in what way educators experience disciplinary systems, nor how their lived experiences affect routine interactions with students. Educators play a key role in implementing PBIS; their experiences foster consistency, trust, and sustainability. The participants included certified educators and administrators employed …

A Qualitative Examination Of Tennessee Secondary Stem Teachers’ Perceptions On Professional Development Needs, Amber W. Ogle

Electronic Theses and Dissertations

The purpose of this qualitative phenomenological study was to research secondary STEM educators’ perceptions of PD needs. This study focused on the lived experiences of educators actively teaching in STEM subject disciplines in grades nine through 12. The essential question for this research study was: How do Tennessee secondary STEM teachers perceive the relevance, applicability, and impact of PD opportunities? The research was rooted in Knowles’ (1984) theory of adult learning, Andragogy, and Learning Forward’s (2022) Standards for Professional Learning.

Data were collected through 15 semi-structured, one-on-one online interviews. The transcripts of these interviews were analyzed, and frequently used language …

Design Of A Continuum Robot Test Bed Utilizing Model-Free Sliding Mode Control, Joseph Paul Streib

Theses

Continuum robots are a class of continually deformable robots inspired by snakes and tentacles that are commonly used in medical, search and rescue, and exploration applications. The robots are highly nonlinear and difficult to accurately model and control. Precise control of the pose of a continuum robot is typically reliant upon a system model. This work introduces a novel model free control algorithm for continuum robots that only relies upon the robot’s position in task space. The derived controller is built upon the foundation of a preexisting model free sliding mode controller and the q-state parameterized piecewise constant curvature kinematic …

Engineering Materials Function With Reconfigurable Colloids, Laura Galeano Tirado

Theses

The function of a material is defined not only by its chemical composition, but also by the structural organization of its constituents across multiple length scales, from the architecture of individual building blocks to their collective arrangement. Developing strategies to access, engineer, and reconfigure that structure on demand represents a central opportunity in the design of adaptive materials. Here, we present a thermoresponsive polymer-colloid platform that enables high-precision tuning of colloidal structures using only thermal stimuli. Rather than adsorbing to the surface, our polymers diffuse inside organosilica colloids to reshape them from within, allowing continuous modulation of their size, shape, …