Digital Commons Network^™

Recurrence And Co-Occurrence Of Enhancer-Promoter Interactions Across Human Samples, Satvik Gunjala

Honors Undergraduate Theses

Experimental mapping of enhancer-promoter interactions (EPIs) is resource-intensive, and current computational prediction methods struggle with intrinsic genomic complexity and reliance on limited training data. To address this bottleneck and provide insights for improved computational methods, this study systematically analyzed chromatin contact datasets to investigate the recurrence and co-occurrence of enhancer-promoter interactions across human samples. Putative interactions were evaluated across two HiChIP datasets comprising 218 total samples and one Hi-C dataset comprising 266 samples to assess recurrence across samples and assess sequencing depth related to unique EPIs. Additionally, a preliminary item-based collaborative filtering recommender model was developed to assess co-occurrence patterns …

Magnesium-Based Metal Matrix Nanocomposite Implants And Nanobubble-Based Delivery Systems: Integrated Strategies For Bone Loss Treatment With Cytocompatibility Evaluation, Lucas José Martinho Bizuti

Honors Undergraduate Theses

This thesis intends to investigate the development of different multimodal therapeutic strategies for combating bone loss. Most specifically, this paper will emphasize the utilization of Magnesium-Based Metal Matrix Nanocomposite Implants (MMNC) and Nanobubble-Based Delivery Systems as options for future treatment focus. The effects of biodegradable magnesium implants were evaluated for cytotoxicity and cytocompatibility via Hematoxylin and Eosin, and Masson’s Trichrome staining, as well as radiological images. The Nanobubble-Based Delivery System is being developed and optimized as a delivery system to target osteoclast activity. This paper focused on optimizing experimental parameters, which include Rotational speeds for nanobubble stimulation under microgravity conditions …

Quantifying Amendment Impact On Microbial Respiration Rate, Qwynn Starrwalker

Honors Undergraduate Theses

Wetlands play a critical role in the global carbon cycle by acting as carbon sinks, where the flooded anaerobic conditions cause slow microbial respiration compared to other soils. Comparatively more carbon is stored in the soil as organic matter than is released as carbon dioxide (CO₂). Making wetland pools of soil organic matter less available to microbes for respiration could reduce overall atmospheric CO₂ and slow global warming. This study examined the effect of kaolinite, goethite, and lime on microbial respiration rates in wetland soils under alternating hydrologic conditions. Homogenized soil from a cypress dome was separated …

Investigating The Relationship Between Metacognition And False Feedback, Sarah M. Grillo

Honors Undergraduate Theses

Accepting false feedback may lead to performance decreases and skewed confidence. Identifying who is more susceptible to false feedback can help us understand how to prevent performance declines and overconfidence. We believe that individuals with low metacognition may be more susceptible to blindly accepting false feedback because they often rely on external sources of feedback for self-evaluation, whereas high metacognitive individuals may be protected because they often rely on accurate internal judgements for self-evaluation. Feedback is important for successful task execution; it can highlight errors (negative feedback) or successful behaviors (positive feedback) to guide future behavior. Individuals with higher metacognition …

The Hungry Mind: Fasting, And Executive Functions In Muslim College Students Living In America, Fatima Alziyad

Honors Undergraduate Theses

Ramadan fasting represents a unique intersection of religious observance and academic responsibility for Muslim college students in the United States. Despite the growing Muslim student population, no U.S.-based research has examined how fasting influences executive functioning within this group. This study investigated the effects of voluntary Islamic fasting on executive functions, specifically working memory, inhibitory control, and sustained attention, using a within-subject crossover design. Muslim undergraduate and graduate students who regularly observe Sunnah fasts completed cognitive testing on one fasting day and one non-fasting day. Working memory was assessed using the 2-back task, inhibitory control using the Stroop task, and …

Vibration-Based Control Of Nonlinear Dynamic Systems, Ossyris N. Bury

Honors Undergraduate Theses

This thesis investigates vibration-based stability as a mechanism for achieving self-stabilizing nonlinear dynamic motion in engineered systems. Inspired by biological hovering flight, in which periodic wing motion can passively enhance stability, the study explores how controlled oscillations can be used to stabilize otherwise unstable mechanical configurations. The research centers on a simplified dynamic model based on the Kapitza pendulum, an inverted pendulum with a vertically oscillating base, which serves as a foundation for understanding vibration-induced stabilization. Analytical modeling using Lagrangian mechanics is employed to derive the governing equations of motion and identify the excitation conditions required for stable inverted behavior. …

Borderline Personality Traits And Their Impact On Facial Ambiguity, Perceived Rejection, And Self-Esteem, Anya Mathur

Honors Undergraduate Theses

The present study examined whether borderline personality disorder (BPD) traits are associated with differences in self-esteem and interpretations of ambiguous facial expressions, as well as how rejection sensitivity relates to these processes. Participants (N = 135) completed measures of BPD traits, rejection sensitivity, and self-esteem, and rated ambiguous facial expressions on perceived emotion, social inclusion, and evaluation. Results indicated that individuals with higher BPD traits reported significantly lower post-task self-esteem and showed a decrease in self-esteem following the task compared to those with lower BPD traits. Contrary to expectations, no significant group differences were found in interpretations of ambiguous facial …

Ai-Thropology: A Study Of Artificial Intelligence Use In Anthropology, Carly R. Junod

Honors Undergraduate Theses

This study examines how undergraduate anthropology students utilize Artificial Intelligence tools in their coursework and the impact on perceptions of learning. As the use of AI becomes more commonplace, I investigated whether it has been integrated into the praxis of undergraduate anthropology students. Using a Likert-scale survey distributed to 26 anthropology students across multiple subfields, I investigated AI usage patterns, perceptions of academic integrity, and correlations with demographic factors. The results reveal that anthropology students exhibit conservative AI usage patterns, with the majority rarely using AI for core academic tasks such as drafting papers. ChatGPT and Grammarly emerged as the …

Effects Of Musical Tempo On Heart Rate, Blood Pressure, And Heart-Rate Variability, Om Pathak

Honors Undergraduate Theses

This study examines how changes in rhythmic patterns and tempo of music affect physiological measures of homeostasis, such as heart rate variability (HRV), blood pressure (BP), and heart rate (HR). HRV is shown to be a biological indicator of aging, to a higher sensitivity than HR and BP. While both HR and BP have shown to remain stagnant and less variable, HRV steadily declines over time - indicative of the declining function of the autonomic nervous system (ANS). Previous studies have demonstrated a physiological effect of music on bodily function - such as through emotive changes and variability within homeostatic …

Relationships Between Quadriceps Neuromuscular Function And Time From Surgery Following Acl Reconstruction Are Sex-Specific, Tatiana Restrepo

Honors Undergraduate Theses

Anterior cruciate ligament reconstruction (ACLR) is associated with persistent quadriceps dysfunction, including muscular weakness and altered spinal and cortical excitability. While recovery has been widely studied, most investigations focus on isolated domains and fixed postoperative time points. Emerging evidence suggests females often experience slower or less complete quadriceps recovery compared to males, yet the time-dependent nature of these sex-specific outcomes remains unclear. The purpose of this study is to examine whether relationships between time since ACLR and quadriceps neuromuscular outcomes differ by sex across muscular, spinal, and cortical domains. Adults aged 18–35 with a history of primary, unilateral ACLR were …

Exploring Anticholinergic Neurotoxicity: Diphenhydramine's Impact On Neuro-2a Cell Morphology, Expression, And Viability, Jordan B. Mcintyre

Honors Undergraduate Theses

Anticholinergic medications, such as diphenhydramine (commonly known as Benadryl), are increasingly recognized for their association with cognitive impairment and neurodegenerative disease. These medications, which inhibit the action of acetylcholine, a neurotransmitter essential for the formation and utilization of the central and peripheral nervous system, have been implicated in conditions such as dementia and may impact fundamental cellular processes like neurogenesis and cell proliferation. This study investigates the effects of diphenhydramine on neurogenesis when introduced to Neuro-2a cells during differentiation. For all studies cells were plated on coverslips or in 6-well plates with differentiation media containing 0 ng/mL, 50 ng/mL, …

Development Of A Split Deoxyribozyme-Based Assay For Detecting Hepatitis B Virus, Dalila Zovko

Honors Undergraduate Theses

Rapid, accessible nucleic acid-based detection methods are needed for hepatitis B virus (HBV). A split deoxyribozyme assay was developed for sequence-specific fluorescence detection. The assay was evaluated using synthetic target and plasmid-derived material. The assay showed target-dependent fluorescence and low-concentration linear range with a LOD of 1.9 nM. The assay supports detection and semi-quantification of HBV genetic material as shown using plasmid-derived transcript samples from HBV genotypes B, C, and D. The selected target corresponded to nt 363–406 of the HBV genome and was chosen based on sequence alignment showing conservation across most genotypes. Genotype-specific detection remains a future application …

A Qualitative Analysis Of Youtube-Based Dietary Messaging On Type 2 Diabetes For South Asians, Sukhmani K. Dhaliwal

Honors Undergraduate Theses

While South Asians experience a disproportionately high risk of Type 2 Diabetes Mellitus (T2DM), culturally tailored dietary guidance remains limited within healthcare settings. As digital platforms increasingly serve as sources of health information, YouTube has grown as a prominent space for the publishing and consumption of dietary advice. This study examines how diet-related messaging about T2DM is communicated in YouTube videos directed at South Asian populations.

Using qualitative thematic analysis, 21 videos published between 2016 and 2025 by influencers with a wide reach were analyzed. Videos were selected based on relevance to South Asian audiences, focus on dietary management of …

“Mother Earth” Faces Sexism” (The Relationship Between Gender, Sexism, And Politics To Climate Change Recognition), Sierra E. Nichols

Honors Undergraduate Theses

Climate change is a prominent scientific and political issue today. Research has shown women to be uniquely vulnerable to the impacts of climate change and subject towards political opinions that can be rooted in sexism. This study aims to draw a correlation between these factors. It provides an overview of the topic of climate change and women’s linkages with the environment through the topic of ecofeminism. It analyzes the topic of sexism and analyzes research surrounding different types of sexism: hostile, benevolent, and modern sexism. It discusses how studies that have categorized climate change as a gendered issue, climate change …

A Secondary Analysis Of The Short-Term Effects Of Kettlebell Swings On Lumbopelvic Pressure Pain Thresholds: A Randomized Controlled Trial, William J. Hanney V

Honors Undergraduate Theses

This study was a secondary analysis of The Short-Term Effect of Kettlebell Swings on Lumbopelvic Pressure Pain Thresholds: A Randomized Controlled Trial as authored by Keilman et al. The study contained 40 healthy young adults and measured the effects of kettlebell swings (KBS) on acute pain perception using pressure pain threshold (PPT). Overall, this secondary analysis utilized a repeated measures ANOVA to determine the significance on dynamic versus static KBS on acute pain perception as measured with PPT. The results were not statistically significant, which suggests that either exercise variation could be performed with similar results in pain perception. Although …

Discomfort In Silence: Investigating Workplace Discrimination In Relation To Employee Disclosure Of Menopausal Health Issues, Alysia Furbish

Honors Undergraduate Theses

Menopause is a universal developmental transition for women that often coincides with peak career years, yet it remains underexamined in organizational research and is frequently treated as a private or taboo workplace topic. This lack of visibility shapes whether women feel able to disclose menopause-related challenges, seek accommodations, and access organizational support. Drawing on literature related to pregnancy and motherhood discrimination, menopause stereotypes, and disclosure literature, this study examines how symptom burden, ideal worker norms, and stigma-related identity management contribute to anticipated workplace discrimination and disclosure decisions. Data were collected via an online survey of 106 working women recruited through …

A Systematic Literature Review Of The Menstrual Cycle And Its Impact On Aerobic Performance In Female Athletes, Jaymie G. Loidolt

Honors Undergraduate Theses

The purpose of this systematic review is to examine existing literature regarding the menstrual cycle and its impact on aerobic performance in female athletes. This comprehensive review was conducted using the PRISMA 2020 method of analysis. All studies included involved normally menstruating females conditioned in endurance sport. Studies analyzing anaerobic sports, abnormally menstruating females, or physically inactive females were excluded. The databases used included: PubMed, Sport Discus, and Web of Science. The results of these were imported into JBIsumari for deduplication, title and abstract, and full text screening. The results conclude objective performance variables are unchanged regarding the phase of …

Dna Half-Adder Based Calculator Driven By 4j Molecular Switches, Andrea Gissele Canizalez Covaleda

Honors Undergraduate Theses

DNA nanostructures have computing functions due to the predictable base pairing of nucleic acids (Watson–Crick). This property allows the programming of DNA circuits that integrate DNA logic gates capable of recognizing oligonucleotides. This molecular device offers the advantages of biocompatibility and potential applications in personalized medicine for diagnosis and therapies.

Our lab has developed DNA logic gates formed by the connection of YES strands via DNA four-way junctions (4J), which can function as molecular switches to develop a DNA-based calculator. Our DNA half-adder calculator nanostructure is designed to recognize up to three combinations of DNA inputs using three DNA strands …

Analysis Of Alternative Gene Splicing Of Natural Killer Cell Exhaustion Markers During Siv Infection, Soledad B. Zayas

Honors Undergraduate Theses

Natural killer cells play a critical role in the innate immune response against Human Immunodeficiency Virus and Simian Immunodeficiency Virus infections. During HIV/SIV infection, NK cells undergo functional impairment characterized by an imbalance between activating and inhibitory surface receptors. The upregulation of inhibitory receptors, TIGIT and TIM-3, has proven to contribute to NK cell exhaustion during different retroviral infections. Although alternative splicing regulates immunity related genes, its role in TIGIT and TIM-3 expression during SIV infection remains poorly understood. This study aimed to characterize alternative splicing patterns of TIGIT and TIM-3 and evaluate transcript variant expression during SIV infection in …

How Religious Priming Affects Morality In Sports, Daniel Prias

Honors Undergraduate Theses

This research focuses on filling the hole in existing literature regarding religious priming and how it affects morality in sports. This study examined whether different types of moral priming influenced moral reasoning in undergraduate soccer athletes. Participants were randomly assigned to one of four conditions: an external religious prime, an internal religious prime, a secular prime, or a no-prime control group. Moral reasoning was assessed using the Moral Reasoning in Sports Scenarios Questionnaire (MRSSQ), strength of religious faith was measured using the Santa Clara Strength of Religious Faith Questionnaire (SCSRFQ), and personality traits were assessed using the Mini International Personality …

The Environmental Impact On The Development Of Equine Degenerative Myeloencephalopathy, Victoria C. Reynolds

Honors Undergraduate Theses

The objective of this study was to examine potential associations between environmental factors and the progression of Equine Degenerative Myeloencephalopathy (EDM). While environmental contributions to neurodegenerative diseases are increasingly recognized in human patients, little is known about their role in EDM. A comprehensive literature review highlighted the lack of research in this area. Data for this study were collected by Dr. Amy Johnson at the University of Pennsylvania's New Bolton Center. The two main areas studied were a horse’s lifestyle (specifically turnout conditions) and their geographical proximity to chemicals (pesticides, airborne neurotoxins, and water contaminants). Statistical analysis revealed there was …

Evaluating The Comparison Of Different Body Locations For Data Collection Using Galvanic Skin Response Of Forensic Chemistry Students When In Lecture And Laboratory Environments, Elisa Guerrero

Honors Undergraduate Theses

Anxiety is the response that humans can have when exposed to a stimulus. It can be caused by a multitude of factors, such as psychological, biological, or physiological stimuli. Anxiety can be presented as a state or as a trait in a person. Trait anxiety is typically seen as a more stable personality trait, whereas state anxiety is a more intense temporary emotional state. In our study, anxiety was regarded as a more state-like characteristic. A galvanic skin response (GSR) Shimmer3+ device can measure skin electro-conductance changes following stimulation. In a situation where a participant is experiencing anxiety, levels of …

Mycoethics: Reverence For Life In Light Of Modern Science, Charis E. Meyers

Honors Undergraduate Theses

There is a 21^st century wave of passion surrounding fungi and mycology, and it’s becoming louder and louder. The mycoenthusiasts themselves have a uniquely inspired ethical system born out of their science, and my aim is to both formally introduce their position, including many unspoken foundations, and defend its potential. I call this position mycoethics and attempt to collect it from the scattered tidbits in mycological media. I first identify its historical precedent, then spend a length of time establishing where its sense of goodness comes from, postulating it as a utilitarian offspring of Albert Schweitzer’s reverence for life. …

How Nature Affects Perceptions Oaf Architectural Details In Office Settings, Autumn R. Hurd

Senior Honors Theses and Projects

The importance of nature in our everyday lives has been well documented and researched. Theories such as the Biophilia Hypothesis, Stress Reduction Theory, and Attention Restoration Theory each attempt to explain why nature influences psychological states. The present research examined the influence of nature in office settings, such that offices with real nature would be seen as more appealing. It was hypothesized that participants would view offices with real plants and nature within or near the settings would be seen as more appealing as compared to similar offices with either AI-Generated nature or no nature within or near the office …

Soil Texture Does Not Affect Multi-Mutualist System Benefits In Prairie Legumes, Ambrose O. Cook

Senior Honors Theses and Projects

No abstract provided.

No Ghost In The Machine: Doubting Ai Ensoulment, Bálint Békefi

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Coral Holobiont Lipidome Response To Global Change, Lauren Zane

Open Access Dissertations

Climate change is fundamentally restructuring macro-scale marine ecosystem structure and function by altering microscale metabolic processes and patterns of energy allocation. Scleractinian corals, as major ecosystem engineers, play outsized roles in ecosystem structure and function. They also occupy diverse habitats that differ in temperature regimes, light environments, hydrodynamics, and other environmental conditions, exposing corals to substantial spatial variation in stress and resource availability. Their fragile nutritional symbiosis with algal endosymbionts helps them navigate these environmental variations, but are also highly sensitive to environmental stress, particularly the timing and magnitude of water temperature changes. As pressure from environmental changes increases, the …

Gamification For Learning At Wvu Tech: Examples From Engineering And Biology, Tamara Floyd-Smith, Aida Elisabet Jiménez-Esquilín

2026 Scholarly Teaching Conference: Poster Session Papers

At WVU Tech, gamification is intentionally implemented by many faculty as a broad, multi-modal instructional approach rather than a single tool or activity. Faculty employ a range of gamification strategies, including the digital platform Kahoot but also analog, hands-on games (e.g., discipline-specific board games). These approaches are used for multiple instructional purposes, including supporting students in checking their understanding, practicing recall, working through challenging concepts, and developing problem-solving skills. Here we present applications of gamification for learning in engineering and biology courses at WVU Tech. Student feedback was collected regarding the use of Kahoot quizzes as a valuable and enjoyable …

Ai-Resistant Activities For Online And Large Enrollment Courses, Jason Bock, Eric Lemley

2026 Scholarly Teaching Conference: Concurrent Session Papers

The rapid adoption of generative AI tools has fundamentally challenged traditional assessments in higher education, particularly in large-enrollment and fully asynchronous online courses where instructor presence and grading time are constrained. While many instructors have responded by restricting AI use or adopting detection tools, research increasingly shows that detection-based approaches are unreliable and labor-intensive. We propose a design-centered alternative: reshaping assessments so that AI use becomes insufficient, rather than prohibited.

Drawing on a systematic process of testing proposed and original assessment ideas directly against multiple generative AI models (using both simple and advanced prompting strategies), we present a curated playbook …

Interacting With Ideas: How To Engage Stem Students In Active Learning Of Theory Using Technology, Jessica Elizabeth Whitney, Keith Brian Morris

2026 Scholarly Teaching Conference: Concurrent Session Papers

STEM education in the modern age has been subject to much reform – from the integration of technology to an emphasis on student-centered teaching strategies, such as active learning. However, in the wake of virtual and blended-learning environments, student engagement and teacher assessment of student success have been challenged. Tools such as KAHOOT! and iClicker have been promoted to foster an active learning environment while sometimes falling short in regards to student retention of course material. In light of this technological educational revolution, instructors need to be able to determine the most effective tools for their discipline to aid in …