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Mortality From Or With Covid-19 Infection, Dagan Coppock, Joseph Glowacki, Constantine Daskalakis, John Zurlo, Nikita Jaggernauth, Daniel Taupin

Division of Infectious Diseases and Environmental Medicine Faculty Papers

In this retrospective study, we compared the cause of death among hospitalized patients who died with a diagnosis of COVID-19 across two periods of the pandemic two years apart: an early period (admissions June to October 2020), when the population was immunologically naïve, and a later period (admissions April to October 2022), when an estimated 96% of the population had immunity from prior infection, vaccination, or both. Two investigators independently reviewed the medical records of 100 in-hospital deaths (50 per period) and classified each death as COVID-19 related, uncertain, or not COVID-19 related, using logistic regression to compare the two …

Exercise Science Pre-At, Kinesiology, Sport, And Recreation

Program Revisions/Additions

No abstract provided.

Environmental Biology, Biological Sciences

Program Revisions/Additions

No abstract provided.

Biochemistry Bs, Chemistry And Biochemistry

Program Revisions/Additions

No abstract provided.

Gis Certficate, Geology And Geography

Program Revisions/Additions

No abstract provided.

Phonics And Friends: A Critical Multimodal Discourse Analysis Of Popular Teacher Influencers' Content, Zachary T. Milford

University of Kentucky Doctoral Dissertations

This critical multimodal discourse analysis examined how five teacher-influencers aligned with the Science of Reading (SoR) movement performed authority, constructed discourses, and used affective and semiotic resources in viral TikTok videos about reading instruction. Drawing on Kress and van Leeuwen's (2001) multimodal social semiotics, Fairclough's (1992) critical discourse analysis, Foucault's (1977, 1982) theorizations of power, Papacharissi's (2014) theory of affective publics, Ong's (1982) secondary orality, and Taussig's (1993) mimesis and alterity, this interpretive, qualitative, multiple-case study analyzed fifty viral TikTok videos and four semi-structured interviews with teacher-influencers. Data were analyzed through within-case and within-mode coding, cross-modal analysis, and cross-case analysis …

Social Isolation Predicts Altered Reward Circuit Connectivity And Future Behaviors In Adolescents, Mason Lucas

2026 Research Poster Competition

Adolescence is a period of transition from childhood to adulthood when people explore risky behaviors. Stressors during adolescence can change structural brain connectivity. Previous research has found weaker structural connectivity between reward circuits and future cognitive impairments among children raised in orphanages. Comparative research in mice suggests that social isolation after bullying can damage these connections and induce alcohol seeking. We tested whether social isolation was related to lower connectivity of targeted structural connections in adolescent humans. We analyzed data from the Adolescent Brain Cognitive Development study and found 130 subjects had experienced extreme social isolation. To evaluate the level …

From Chaos To Clockwork: Investigating The Role Of Circadian Genes In Metabolic Development Of 2nd And 3rd Instar Drosophila Larvae, Elliott Ruegsegger

2026 Research Poster Competition

Connecting deficits in circadian rhythm machinery to the severity of other health conditions is a common task that chronobiology, the study of physiological rhythms, undertakes. Disruptions to circadian rhythms and sleep are linked to increased risk of developing multiple different diseases, including Alzheimer’s Disease and obesity. Circadian rhythms are expressed at the molecular level through rhythmic variations in the concentration of specific proteins. While the central clock genes that produce these proteins, such as period and timeless, are evolutionarily conserved across the animal kingdom, not much is known about the consequences of disruptions in circadian rhythm machinery during early development, …

Moving Towards Defining The Evolutionarily Ancient Role Of Notch Signaling In Animals., Paige Norris

2026 Research Poster Competition

The notch signaling pathway is deeply conserved across animals from humans to sponges. It functions through direct cell-to-cell communication, where ligand binding triggers the cleavage of the Notch receptor’s intracellular domain (NICD), which then translocates to the nucleus to regulate transcription. In bilaterian lineages—animals with bilateral symmetry— Notch signaling is known to regulate binary cell fate decisions in diverse contexts ranging from neurogenesis to cancer. However, the functions of Notch signaling in early-branching animals, including cnidarians (e.g. jellyfish, corals and sea anemones), are still not fully understood; consequently, evolutionarily ancient roles of Notch remain ill-defined. To address this fundamental knowledge …

Methanogens On Asteroids?, Isabella Reimer

2026 Research Poster Competition

Methanogens on Asteroids? Introduction: It is conceivable that if methanogens, microorganisms in the domain Archaea, exist on Mars, they were seeded there from a piece of Earth that was ejected by a meteor impact sometime in the past, or that material from Mars seeded our home planet by the same mechanism. The hypothesis of panspermia, the idea that life could be transported from one planet to another through space, was first developed by Arrhenius in 1908 (1). Since then, the idea of lithopanspermia, the transfer of organisms in rocks such as meteors and asteroids, has become amenable to testing. Previous …

Investigating Pituitary Specific Transcription Factor-1 (Pit-1) In Neuronal Development In The Sea Anemone Cnidarian Nematostella Vectensis, Emily Ye

2026 Research Poster Competition

In bilaterians — animals with bilateral symmetry, like vertebrates and insects — the pituitary specific transcription factor-1 (pit-1) is essential for regulating growth hormone and prolactin expression in the pituitary gland. However, in non-bilaterians, the ancestral function of pit-1 remains unknown. Cnidarians, such as the sea anemone Nematostella vectensis, form a sister group to bilaterians and lack a pituitary gland, making them a powerful model for investigating the early evolutionary role of conserved developmental genes, like pit-1.Using CRISPR-mediated gene editing, pit-1 knockout mutants — anemones without the pit-1 gene — were generated, and their transcriptomic, cellular, and behavioral phenotypes were …

Optimizing Microscale Tesla Valve Design For Enhanced Efficiency For Filtering And Sorting Bacteria, Brian Ewalt

2026 Research Poster Competition

Invented by Nikola Tesla in 1920, a Tesla valve is a passive check valve with no moving parts but showing diodicity for fluids (i.e., allowing fluids to flow easily in one direction but not in the other). Tesla valves have demonstrated remarkable versatility across a range of scientific fields. Recently, a study conducted at the University of Arkansas showed that these conduits exhibited diodicity for bacteria in the absence of fluid flows (Rogers et al. 2023), serving as proof of concept for applying microscale Tesla valves for filtering and sorting bacteria and microorganisms in biomedical settings. However, the design of …

Assessing Mesenchymal Stem Cell Phenotype After Heparan Sulfate Supplementation, Isani Patel

2026 Research Poster Competition

Multiple sclerosis is an autoimmune disease that damages the protective coating of nerves, often causing lasting neurological symptoms. Current treatments slow disease activity but rarely repair existing damage. In response to this, a novel treatment option has emerged: mesenchymal stem cell (MSC) therapy. MSCs are cells found in different adult tissues like bone marrow, and they have the potential to release repair-supporting signals and moderate inflammation. Nevertheless, results in a clinical setting have been inconsistent due to variations in cell potency. As a potential strategy to enhance MSC therapeutic potential, the addition of heparan sulfate, a naturally occurring signaling molecule, …

Building Mental Health Literacy: The Impact Of Youth Mental Health First Aid On Emerging Youth Professionals, Burgin Rome

2026 Research Poster Competition

Nearly half of individuals in the United States will experience a mental health disorder during their lifetime, with many symptoms first emerging in childhood or adolescence. Adolescence is a critical developmental period characterized by emotional, social, and psychological changes that increase vulnerability to mental health challenges. Although public awareness of mental health has grown, stigma and societal taboos continue to limit open dialogue and delay intervention. As a result, many young people experience a significant gap between the onset of symptoms and receipt of professional support, which can worsen mental health concerns and contribute to long-term consequences that persist into …

Chronostratigraphy Using Stable Carbon Isotopes Of The Elliot Formation, South Africa, Aidan Del Pino

2026 Research Poster Competition

The Elliot Formation in South Africa preserves a fossil-bearing record spanning the Late Triassic–Early Jurassic, a time marked by significant environmental changes related to the Central Atlantic Magmatic Province (CAMP) and the end-Triassic extinction event. Despite its importance, the Elliot Formation remains poorly constrained due to limited chronostratigraphic markers. Chronostratigraphy is the branch of geology that correlates and dates rock units in time, allowing researchers to arrange these rock units into a chronological sequence. Globally, the Triassic–Jurassic boundary is characterized by a pronounced negative carbon isotope excursion linked to CAMP volcanism and the end Triassic extinction event. This C-isotope excursion …

Investigating Changes In White Blood Cell Composition In Wild Hosts In Response To Viral Infection, Anna Bolding

2026 Research Poster Competition

Reservoir hosts play a critical role in the persistence and spillover of zoonotic pathogens. Upon infection, reservoir hosts can shed viral loads sufficient for transmission and spillover often without displaying apparent pathogenic effects. Investigating how their immune systems control infection can provide insights into the factors that facilitate spillover events. Understanding the mechanisms that enable these infection characteristics is crucial for informing public health and conservation strategies. Though reservoir hosts’ immune responses are well-documented in controlled laboratory settings, these studies are not representative of natural populations. The bank vole - Puumala hantavirus (PUUV) system is well suited for investigating such …

Temporal Variational Graph Autoencoder For Influenza Evolution, Soumya Chauhan

2026 Research Poster Competition

Frequent mutations in influenza virus surface proteins can increase infectivity while evading human and vaccine immunity, causing seasonal epidemics. The CDC annually evaluates thousands of virus strains to predict mutated sequences likely to be dominant in the next season, which creates a need for methods that better capture how viral mutations evolve over time. In this study, we represent influenza protein sequences as a network-like graph, creating connections if sequences are collected a week apart and only differ by one mutation. This method explicitly considers time information as part of the evolution, while other existing methods analyze mutated sequences without …

Investigating The Potential Role Of Horse Flies (Diptera: Tabanidae) In The Mechanical Transmission Of Anaplasma Marginale And Theileria Orientalis To Cattle In Northwest Arkansas, Catherine Harrison

2026 Research Poster Competition

The cattle industry in Arkansas plays a significant role in the state’s agricultural economy; however, two emerging infectious diseases pose a threat to cattle health, producer livelihood, and animal welfare. The two diseases, anaplasmosis and theileriosis, are caused by organisms that enter the host’s bloodstream and infect red blood cells, leading to destruction of said cells. The shared symptoms of both diseases are fever, weakness, anemia (low red blood cell count), reduced productivity, weight loss, and possibly death. An important difference between symptoms is that, unlike anaplasmosis, theileriosis can cause abortion in cattle. Both diseases are known to spread through …

Examining Life Course Trends In Dental Tissues Measurements In Members Of The Cayo Santiago Macaque Colony, Tyler Moore

2026 Research Poster Competition

Dental tissue dynamics in primates are largely understood: as enamel wears with tooth use, tertiary dentin is laid down in response to cumulative (micro)traumas, compressing the internal pulp chamber and root canals. However, our knowledge of the rate and pattern of change in tissue quantities across the life course of primates remains incomplete, particularly in well-documented free-ranging populations. This study examined age- and sex-related variation in dental tissue surface area (SA) and volume (V) in a skeletal sample of rhesus macaques (Macaca mulatta) from the Cayo Santiago colony (Puerto Rico), a population with known life history data. Forty-six individuals were …

Uav-Based Sensor Integration For In-Situ Lake Water Quality Monitoring, Alec Campbell

2026 Research Poster Competition

Current water quality assessment methods rely heavily on manual sampling and laboratory analysis, which are time-consuming and difficult to perform in remote or hazardous environments. In surface water monitoring, spatial and temporal resolution is often constrained by labor, access, and logistical limitations of manual sampling programs. This research aims to develop a drone-based system for real-time, in situ lake water quality monitoring. To address these challenges, the project focuses on integrating multiple water quality sensors, including oxidation-reduction potential (ORP), pH, electrical conductivity (EC), turbidity, and a multispectral spectrometer, into a compact, UAV-compatible design capable of collecting spatially referenced data. Methods: …

Functional Characterization Of The Reniform Nematode Effector Protein Rr6640 In Soybean Parasitism, Noah Solomon

2026 Research Poster Competition

Reniform nematode (Rotylenchulus reniformis, RN) is a major plant-pest affecting key crops in Arkansas such as cotton and soybean, causing economic losses exceeding $757 million in the U.S. over the past decade. While some genetic resistance exists in cotton, soybean remains highly susceptible, exacerbating RN populations in crop rotations. To address this gap, this research investigates the mechanisms of nematode infection focusing on effectors, the specialized proteins secreted by the parasite to manipulate host cell biology and suppress plant immunity. This study characterizes Rr6640, a putative effector gene identified as an ortholog to a virulence factor in the Beet Cyst …

Testing The Effects Of Mechanical Stimulation On Mesenchymal Stem Cell Cultures, Ella Collis

2026 Research Poster Competition

Mesenchymal stem cells (MSCs) are a promising treatment option for a variety of diseases due to their ability to migrate to far-off sites, modulate inflammatory immune responses, secrete factors that aid in tissue healing, and their capacity to become several cell types. These cells can be found and isolated from various body tissues including bone marrow and adipose tissue, even so the number of cells obtained from these tissues is minimal compared to the amounts needed for their transplantation in cell therapy treatments. Therefore, their culture in plastic dishes is required to increase the number of cells and obtain the …

Effectiveness Of Occupational Recommendations In Maintaining Cognitive Function Under Hot-Dry And Warm-Humid Conditions, Zane Garner

2026 Research Poster Competition

National Institute for Occupational Safety and Health (NIOSH) recommendations dictate heat safety practices in occupations throughout the United States. Currently, the effectiveness of these recommendations is unknown. Likewise, there is a lack of consensus regarding the effect of combined heat and exercise stress on cognitive function. PURPOSE: To examine the effectiveness of NIOSH heat safety recommendations in maintaining cognitive function after moderate work in the heat, alongside whether the type of heat has any effect. METHODS: A counter balanced, repeated measures, randomized controlled trial was conducted to evaluate differences in cognitive function in two distinct environments. Participants completed two experimental …

Developing A Cpp-Conjugated Cas9 Library For Efficient Non-Viral Delivery To The Dmd Gene, Amie Donathan

2026 Research Poster Competition

Duchenne muscular dystrophy, or DMD, is a genetic neuromuscular disorder caused by the mutation of the DMD gene, resulting in alterations in the functionality or production of dystrophin, a protein essential to maintain muscle fiber integrity and strength. This mutation leads to progressive muscle degeneration, causing motor loss, cardiopulmonary failure, and ultimately, premature death. Gene therapies using CRISPR aim to replace the mutated gene to provide long-term correction. Although this has promise, CRISPR-based therapies use a viral vector to deliver, which presents notable challenges, such as immune problems and liver toxicity. A non-viral delivery method is a viable approach, but …

Macroinvertebrate Taxonomic And Functional Diversity In The Spokane River Watershed, Kaitlin L. Abell

EWU Masters Thesis Collection

Changes in land use, such as agricultural expansion, have impacted stream systems by modifying discharge, substrate diversity, channel morphology, and nutrient inputs. The Spokane River Watershed is heavily impacted by human activity, including urban and agricultural development. Rehabilitation efforts are being organized to reintroduce Salmonidae species in the Spokane River Watershed. The first step of this reintroduction is to perform habitat studies to inform allocation of restoration efforts. As part of this effort, I performed benthic macroinvertebrate surveys throughout the watershed.

The objective of my research was to use the macroinvertebrate community as a biological indicator to determine which habitat …

A Bayesian Late-Fusion Supportability Framework For Rare-Disease Severity Prediction In Glut1 Deficiency Syndrome, Jordan M. Rodriguez

Mathematics Dissertations

Glucose transporter type 1 deficiency syndrome (GLUT1-DS) is a rare neurometabolic disorder with heterogeneous neurological and developmental severity. Because patient-level severity is not observed as a single validated outcome, this dissertation develops a Bayesian late-fusion supportability framework for constructing and predicting an ordered latent severity phenotype from clinical, genetic, and EEG-derived evidence. The primary target was constructed in a larger clinical cohort using age-5 symptom burden and learning cognition, then assigned to an aligned multimodal prediction cohort. Target-defining variables were excluded from supervised predictors, and models were evaluated using patient-exclusive cross-validation with training-fold preprocessing and fold-wise EEG PCA.

The primary …

Genome-Wide Gene-Sleep Interaction Study Identifies Novel Lipid Loci In 732,564 Participants, Raymond Noordam, Wenyi Wang, Pavithra Nagarajan, Heming Wang, Michael R Brown, Amy R Bentley, Qin Hui, Aldi T Kraja, John L Morrison, Jeffrey R O'Connel, Songmi Lee, Karen Schwander, Traci M Bartz, Lisa De Las Fuentes, Mary F Feitosa, Xiuqing Guo, Xu Hanfei, Sarah E Harris, Zhijie Huang, Mart Kals, Christophe Lefevre, Massimo Mangino, Yuri Milaneschi, Peter J Van Der Most, Natasha L Pacheco, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Quan Sun, Yasuharu Tabara, Dina Vojinovic, Yujie Wang, Stefan Weiss, Qian Yang, Wei Zhao, Wanying Zhu, Md Abu Yusuf Ansari, Hugues Aschard, Pramod Anugu, Themistocles L Assimes, John Attia, Laura D Baker, Christie Ballantyne, Lydia Bazzano, Eric Boerwinkle, Brain Cade, Hung-Hsin Chen, Wei Chen, Yii-Der Ida Chen, Zekai Chen, Kelly Cho, Ileana De Anda-Duran, Latchezar Dimitrov, Anh Do, Todd Edwards, Tariq Faquih, Aroon Hingorani, Susan P Fisher-Hoch, J Michael Gaziano, Sina A Gharib, Ayush Giri, Mohsen Ghanbari, Hans Jörgen Grabe, Mariaelisa Graff, C Charles Gu, Jiang He, Sami Heikkinen, James Hixson, Yuk-Lam Ho, Michelle M Hood, Serena C Houghton, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Tuomas O Kilpeläinen, Pirjo Komulainen, Henry J Lin, Gregorio V Linchangco, Annemarie I Luik, Jintao Ma, James B Meigs, Joseph B Mccormick, Cristina Menni, Ilja M Nolte, Jill M Norris, Lauren E Petty, Hannah G Polikowsky, Laura M Raffield, Stephen S Rich, Renata L Riha, Thomas C Russ, Edward A Ruiz-Narvaez, Colleen M Sitlani, Jennifer A Smith, Harold Snieder, Tamar Sofer, Botong Shen, Jingxian Tang, Kent D Taylor, Maris Teder-Laving, Rima Triatin, Michael Y Tsai, Henry Völzke, Kenneth E Westerman, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Alan B Zonderman, Xiaofeng Zhu, Jennifer E Below, Simon R Cox, Michelle Evans, Myriam Fornage, Ervin R Fox, Nora Franceschini, Sioban D Harlow, Elizabeth Holliday, M Arfan Ikram, Tanika Kelly, Timo A Lakka, Deborah A Lawlor, Changwei Li, Ching-Ti Liu, Reedik Mägi, Alisa K Manning, Fumihiko Matsuda, Alanna C Morrison, Matthias Nauck, Kari E North, Brenda Wjh Penninx, Michael A Province, Bruce M Psaty, Jerome I Rotter, Tim D Spector, Lynne E Wagenknecht, Ko Willems Van Dijk, Lifelines Cohort Study, Million Veteran Program, Cashell E Jaquish, Peter Wf Wilson, Patricia A Peyser, Patricia B Munroe, Paul S De Vries, W James Gauderman, Yan V Sun, Han Chen, Clint L Miller, Thomas W Winkler, Dabeeru C Rao, Susan Redline, Diana Van Heemst

Faculty, Staff and Student Publications

Background and aims: Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets.

Methods: We collected data from 55 cohorts with a combined sample size of 732,564 participants (87 % European ancestry) with data on lipid traits (high-density lipoprotein [HDL-c] and low-density lipoprotein [LDL-c] cholesterol and triglycerides [TG]). Short (STST) and long (LTST) …

Blood Flow Regulates Metabolism In Hematopoietic Development, Pamela L Wenzel

Faculty, Staff and Student Publications

Blood flow modifies oxygen availability and biomechanical forces within the vasculature of the embryo as the hematopoietic system develops. The aorta-gonad-mesonephros (AGM) envelops the largest artery in the body and is a critical site for the emergence of hematopoietic stem cells (HSCs). Herein, I discuss the role of hypoxia-inducible factors (HIFs) and force as determinants of metabolism and fate determination. To address the effects of blood flow on hematopoietic development, I employ mouse embryo models and biomimetic culture. Real-time cell metabolic analyses show that oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) are altered by flow in cultures of …

Updates To Version 1.0 Of The Four‐Dimensional Ecology Education Framework Create Version 1.1., Christopher W. Beck, Loren B. Byrne, Jennifer Doherty, Amanda E. Sorensen, Et Al.

Arts & Sciences Faculty Publications

Since its introduction in 2018, the Four-Dimensional Ecology Education (4DEE) Framework has advanced ecology education. Yet, ecology educators have had different understandings of aspects of the Framework. Here, we describe the updates to the original Framework that aim to provide more clarity. Specifically, we describe higher-level changes in how the Framework is presented on the 4DEE website, changes to some of the elements within the dimensions, mostly in the Human–Environment Interactions dimension, and perhaps most substantively, replacing the lists of subelements with more descriptive paragraphs that explain the intent of the elements. We hope that these updates will promote the …

Comparative Evaluation Of Hplc And Capillary Electrophoresis In Intestinal Permeability Of Oseltamivir Phosphate Via Single-Pass Intestinal Perfusion (Spip) Method, Senem Şanli, Gülpembe Halay, Mustafa Sinan Kaynak, Nurullah Şanlı

Arts & Sciences Faculty Publications

Introduction: Oseltamivir phosphate (OP), a widely used antiviral prodrug for influenza, requires accurate Biopharmaceutics Classification System (BCS) classification to inform formulation and bioequivalence decisions. Despite its high solubility, the permeability characteristics of OP remain inadequately defined. Methods: This study evaluated the intestinal permeability of OP using the in situ Single-Pass Intestinal Perfusion (SPIP) model in male Sprague Dawley rats. Two validated analytical methods - High-Performance Liquid Chromatography (HPLC) and Capillary Zone Electrophoresis (CZE) were developed and compared. Metoprolol tartrate served as the high-permeability reference standard, and phenol red was used to monitor water flux. Permeability coefficients (Peff) were calculated after …