Digital Commons Network^™

Hypoxic Stem Cells From Apical Papilla-Derived Exosomes Enhance Dental Pulp Stem Cells Migration And Differentiation Via Mitochondrial Activation, Deyan Yuan, Rui Tao, Bi Yin, Meng Gu

Journal of Dental Sciences

Background/purpose Stem cells from apical papilla (SCAPs) and dental pulp stem cells (DPSCs) play critical roles in dental tissue regeneration. Although intercellular communication through exosomes is known to influence stem cell regulation, the effects of exosomes derived from hypoxic SCAPs on the migration and odontogenic differentiation of DPSCs have not been elucidated. This study aimed to investigate SCAPs derived exosomes mediated modulation of DPSCs biological functions under hypoxic conditions. Materials and methods Exosomes were obtained from SCAPs cultured under normoxic or hypoxic conditions. DPSCs were treated with these exosomes, and their migration capacity was evaluated using scratch and transwell assays. …

Evaluation Of Gpt-4o And Gemini Advanced On The Korean National Dental Licensing Examination: Accuracy, Consistency, And Question Generation, Eun Sun Song, Ga Hyeon Kim, Seung-Pyo Lee

Journal of Dental Sciences

Background/purpose Large language models (LLMs), such as GPT-4o and Gemini Advanced, have performed strongly on global medical examinations. However, their capabilities in non-English, dentistry-specific licensing contexts remain unclear. Thus, this study aimed to compare the performance, consistency, and question-generation abilities of GPT-4o and Gemini Advanced in the Korean National Dental Licensing Examination (KNDLE). Materials and methods This study used 1,401 text-based KNDLE questions from 2019 to 2023 in Korean. Each model responded to the questions in three separate runs. Accuracy and consistency were compared with human answers. The models generated new questions in four subject areas and attempted to solve …

Biofunctionalized 3d-Printed Gelatin-Alginate Scaffolds With Arginine-Glycine-Aspartic Acid (Rgd) Peptides For Enhanced In Vitro Osteogenesis, Ting-Yi Renn, You-Ru Ma, Chia-Chen Hsu, Eisner Salamanca, Hiroshi Egusa, Ying-Sui Sun, Chun-Pin Lin, Wei-Jen Chang

Journal of Dental Sciences

Background/purpose Alveolar bone defects are difficult to treat due to ongoing resorption and limitations of conventional grafts. Tissue engineering strategies, particularly 3D hydrogel-based scaffolds, offer promising alternatives by mimicking the extracellular matrix and supporting cell-driven regeneration. This study aimed to incorporating arginine-glycine-aspartic acid (RGD) peptides into 3D-printed gelatin-alginate hydrogels to enhances their bioactivity and osteogenic potential for effective alveolar bone repair. Materials and methods The physical characterization of RGD peptides-grafted 3D-printed gelatin-alginate scaffolds was conducted using morphological observation, elemental composition analysis, Fourier-transform infrared spectroscopy (FTIR), and assessments of swelling and degradation behavior. Biological performance was examined in vitro through cell …

The Presence Of Thyroid Autoantibodies Is Not Associated With Anemia, Hematinic Deficiencies, And Hyperhomocysteinemia In Oral Lichen Planus Patients, Yi-Pang Lee, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang

Journal of Dental Sciences

Background/purpose: Our previous study found that 144 of 588 oral lichen planus (OLP) patients have thyroglobulin antibody (TGA) and/or thyroid microsomal antibodies (TMA) but do not have gastric parietal cell antibody (GPCA, designated as thyroid autoantibodies-positive OLP or TA⁺OLP patients). To test the role of thyroid autoantibodies in causing microcytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia in OLP patients, this study assessed whether 144 TA⁺OLP patients had significantly higher frequencies of microcytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than 588 healthy control subjects (HCSs) or 305 TGA/TMA/GPCA-negative (Abs^–) OLP patients (designated as Abs^–OLP patients). …

Dupilumab For The Treatment Of Prurigo Nodularis, Iain Noel Encarnacion, Noelle Desir, Simona A. Alomary, Nicole Baker

SKMC Student Presentations and Publications

Prurigo nodularis (PN) is a chronic, intensely pruritic dermatosis driven by neural and immune dysregulation, with historically limited FDA-approved treatment options. In September 2022, dupilumab became the first FDA-approved therapy for PN. To review the clinical efficacy of dupilumab in PN, with emphasis on pivotal clinical trials, real-world evidence, and safety profile. We examined mechanistic studies of dupilumab, early case reports and series, phase 3 LIBERTY-PN PRIME and PRIME2 randomized trials, real world observational studies, and safety data. Dupilumab, a human monoclonal antibody targeting IL-4Rα, suppresses type 2 inflammation. In PRIME (n = 151) and PRIME2 (n = 160), dupilumab …

Teaching Primary And Secondary Computing: A Comparative Study Of Classroom Practices And Resources In The Uk And Ireland, Robert Whyte, Diana Kirby, Elizabeth Cole, Tom Crick, Nicola Looker, Keith Quille, Sue Sentance

Research Outputs: 2025-Present

Background and Context: As more K–12 teachers are required to teach computing, there is a need to understand how it is enacted in classrooms. In addition, many non-specialists are teaching computing for the first time. Objective: We set out to better understand how computing is currently being taught across five jurisdictions in the UK and Ireland. The aim of the study was to understand CS teaching practices, including the use of certain approaches and resources in the computing classroom. Method: We analysed survey data from 475 primary and secondary teachers across a number of relevant categories: teachers’ use of CS …

Shining Light On Infection Control: Tio2–Graphene Hybrids As Next-Gen Germicidal Platforms, Mirela Petruta Suchea, Petronela Pascariu, Ioan Valentin Tudose, Maria Orfanou, George Kenanakis, Emmanouel Koudoumas, Stefan Bucur, Ryan Walden, Keerthi M. Nair, Christopher Golden, Mary Heneghan, Suresh C. Pillai, Finn Purcell-Milton, Declan Mccormack

Research Outputs: 2025-Present

The development of next-generation germicidal platforms is a critical response to rising microbial resistance and the global demand for sustainable disinfection technologies. This review offers a comprehensive analysis of hybrid materials based on pure and doped titanium dioxide (TiO₂) and graphene, focusing on their synergistic potential for enhanced germicidal applications. The paper begins with a brief overview of the structural, optical, and electronic properties of TiO₂ and graphene relevant to photocatalysis and antimicrobial activity. Recent advances in TiO₂ bandgap engineering-via doping and nanostructuring-are discussed in connection with improved UV and visible light–driven photocatalytic performance. In parallel, …

Orthokeratinized Odontogenic Cyst Of The Mandible - A Case Report, Hung-Pin Lin, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Investigating Sex Differences In The Regulation Of Conditioned Morphine Reward By Orexin, Farzana Akter Koly

Psychology Theses

Strong activation of the brain’s reward circuitry by morphine and morphine-associated cues drives the progression toward morphine abuse. Additionally, orexin neurons in the lateral hypothalamus (LH) are activated in response to cues paired with morphine reward. The orexin system, particularly the orexin-1 receptor (OX1R) regulates reward-seeking behavior through its activation. Despite the well-established role of orexins in reward-related behaviors, the specific contribution of OX1R in morphine-associated reward remains unclear. Furthermore, while sex differences in drug reward and reward-related behaviors are well documented, they remain unexplored in the regulation of morphine-associated reward by orexins. To address this gap, the present study …

Characterizing Gut Microbial Communities And Symbiont-Mediated Detoxification In Herbivorous Insects, Rachel C. Vargas

Biology Dissertations

Insect gut bacteria are vital contributors to host physiology, yet the broader prevalence and fitness implications of symbiont-mediated detoxification remain poorly understood. This thesis investigates these dynamics across three research chapters. Chapter 1 uses 16S rRNA sequencing to characterize how grasshopper gut microbial communities vary across species, dietary breadths, and gastrointestinal segments. Chapter 2 evaluates the detoxification capacity of over 150 bacterial isolates from diverse herbivores against the plant allelochemicals phenethyl isothiocyanate, rutin, and chlorogenic acid to determine if host dietary specialization predicts microbial metabolic ability. Finally, Chapter 3 employs fitness bioassays to test whether inoculating generalist herbivores with detoxifying …

Navigating Family, Culture, And Well-Being: A Qualitative Study Of First-Generation Adult Children Of Middle Eastern Immigrants In The United States, Ramona Amely

Antioch University Dissertations & Theses

The purpose of this study is to explore the lived experiences of first-generation adult children of Middle Eastern immigrant parents/caregivers living in the United States. This was a phenomenological study with reflexive thematic analysis. Participants (N=10) were interviewed via Zoom, and transcripts were analyzed using Reflexive Thematic Analysis (RTA). The results included four themes: (1) Migration Contact and Cultural Formation, (2) Bicultural Identity Development, (3) Family System Adaptation, and (4) Emotional Socialization and Psychological Impact. This study highlights how first-generation adult children of Middle Eastern immigrants navigate complex, interwoven processes of bicultural identity development, family adaptation, and emotional socialization shaped …

Low Energy Availability And Dietary Factors In High School Runners, Natalie E. Allik

All Master's Theses

ABSTRACT

LOW ENERGY AVAILABILITY AND DIETARY FACTORS IN HIGH SCHOOL RUNNERS

By

Natalie Elizabeth Allik

June 2026

Context: Low energy availability (LEA) is associated with adverse health and performance outcomes in athletes and may be particularly concerning during adolescence when growth and bone development are ongoing. Although inadequate carbohydrate (CHO) intake has been proposed as a contributor to LEA, limited research has examined this relationship in adolescent endurance athletes. Objective: To examine dietary intake, bone mineral density (BMD), and eating disorder (ED) risk in adolescent distance runners with and without LEA. Methods: Eighteen adolescent distance runners (15.7 ± 1.2 years; …

Paleo-Environmental Change In Deer Lagoon, Whidbey Island Interpreted From Diatoms And Lithology, Lourdes Garcia

All Master's Theses

Puget Sound is a densely populated, tectonically active area that can be affected by earthquakes from local crustal faults and the Cascadia subduction zone capable of producing abrupt coseismic subsidence. Tidal wetlands are particularly sensitive to abrupt changes because they are depositional environments that reside at sea-level and their lithology and ecological communities are strongly controlled by elevation within the tidal frame. As a result, coseismic subsidence can disrupt established environmental gradients and leave distinguishable signatures preserved within the stratigraphy, like tidal mud directly over peat deposits. These preserved records provide an opportunity to reconstruct past earthquakes and associated relative …

Exploring Students' Perceptions Of Active Learning Practices And Their Role In Critical Thinking Development In Undergraduate Biology Education, Kwame Kyeremah

All Master's Theses

As the global landscape becomes increasingly complex and undergoes more rapid changes than ever before, critical thinking has become an indispensable skill for addressing challenges in society, science, and the workplace. Despite its widespread adoption in undergraduate STEM education, active learning remains poorly understood from the student's perspective. This study investigated how undergraduate biology students perceived active learning in a ten-week biostatistics course (BIOL 213) at Central Washington University, and whether those perceptions aligned with critical thinking gains measured by the California Critical Thinking Skills Test with Numeracy (CCTST-N). A convergent mixed-methods design integrated student perception and mindset survey data …

Artistic Merit In The Wind Band Repertoire: A Critical Analysis Of Jarod Hall’S “Golden Horizons”, Eric Mills

All Master's Theses

The wind band repertoire has long been subject to rigorous scrutiny regarding its artistic legitimacy, and scholars have invested considerable effort in developing frameworks through which that legitimacy can be assessed. The most enduring of these is Acton Ostling's ten criteria of serious artistic merit, formulated in 1978 and tested across nearly half a century of subsequent scholarship. This thesis argues that JaRod Hall's Golden Horizons (2024) satisfies those criteria, through a close analysis of a single contemporary work, and what it reveals about the framework's continued analytical utility.

The methodology combines a review of the scholarship surrounding Ostling's framework, …

American Elderberry's Next Top Pollinator: Evaluating The Role Of Arthropods In Pollination, Jenny K. Burrow

Graduate Theses/Dissertations

American elderberry (Sambucus nigra subsp. canadensis) is a woody deciduous shrub native to eastern North America. In addition to its long history of use by indigenous peoples, there is renewed interest in cultivating and consuming American elderberry, primarily driven by expanding health supplement markets. Despite recent advances in horticultural development of American elderberry, its pollination ecology remains poorly understood. In this field study, I evaluated the contribution of arthropod visitors to pollination of American elderberry. To do this, I first characterized the identities and abundances of arthropod visitors via timed arthropod collections and floral observations during peak flowering …

Human Plasma Extracellular Vesicles As An Exercise Mimetic To Preserve Skeletal Muscle Plasticity During Disuse, Alexander M. Fliflet, Yanqi Tan, Takeshi M. Barnes, Ane Nishitha Vijayan, Sung Jun Choi

Kinesiology & Sport Management Scholarship

The purpose of this study was to determine the extent to which extracellular vesicles (EVs) circulating in blood after exercise training act as an effective mimetic to maintain skeletal muscle mass during unloading and/or accelerate recovery after disuse. Ten healthy males (27.7 ± 7.1 y) were recruited for a 6-week progressive resistance and endurance training program. EVs were isolated from blood before (EVs) or immediately after training (ExerVs). EVs were intraperitoneally injected into male mice (4×; 3 × 108 particles/injection) during 14 days of hindlimb unloading (HU), then the muscles were collected immediately or 7 days after HU. ExerVs did …

Coloring Outside The Lines: Antiracist Aesthetics In The Detective Novels Of Chester Himes, Kam Shapiro

Faculty Publications – Politics and Government

In a series of detective novels published between 1957 and 1969 Chester Himes portrayed diverse individuals struggling for survival, wealth, and status in a fictionalized postwar Harlem, combining what Richard Wright called a “bio-social” perspective with an antiracist aesthetics that falsified simplistic racial categories. In this essay, I trace Himes’s renderings of bodily difference and transformation, highlighting features neglected by contemporaries such as Ellison and Baldwin as well as more recent critics and readers who frame Himes’s writings as protests against anti-Black violence. I conclude that Himes’s Harlem novels did not simply reflect violent realities of African American lives but …

2026 Oer Deep Dive, Caterina B. Azzarello, Cassendra Bergstrom, Kirsten Gilderhus

About OER

The Affordable & Open Educational Resources (AOER) Committee at UNC, in collaboration with the Colorado Department of Higher Education, UNC’s Center for the Enhancement of Teaching and Learning, and the University Libraries, hosted an in-person OER Deep Dive professional development workshop on Tuesday, May 19, 2026. This full-day event was created for faculty and staff interested in learning more about Open Educational Resources (OER) and exploring ways to incorporate them into their instructional practices.

Throughout the workshop, participants examined the foundations of OER, discussed distinctions between openly licensed and freely available materials, and explored the role of affordable course content …

How Effective Is Online Teaching Of Physiology Modules? Perception Of Rwandan Health Sciences Students, Abdullateef Isiaka Alagbonsi, Mojeed Akorede Gbadamosi, Mathieu Nemerimana, Makinde V. Olubiyi, Olufunke Onaadepo, Akaninyene Ubong Ime, Abdul-Rahuf Aderemi Feyitimi, Ruth Wanjiru Mungai, Florent Rutagarama, Simiat Elias

Biomedical Sciences, East Africa

Background: While blended teaching is approved in Rwandan medical education, the perceived effectiveness of online-only delivery for physiology modules remains unclear. This uncertainty limits its continued use. The present study assessed Rwandan health sciences students’ perceptions of the effectiveness of online teaching for physiology modules.

Methods: A total of 528 students from medicine and surgery (n = 300), pharmacy (n = 99), dentistry (n = 89), and clinical psychology (n = 40) programs at the University of Rwanda completed an online questionnaire. Data were analyzed using multivariable logistic regression and non-parametric tests (Mann-Whitney U, Kruskal-Wallis) with corresponding effect …

Examining The Drivers, Consequences, And Depoliticization Strategies Of Greenhouse Gas Emission Polarization Among The American Public, Lauren Wilner

Environmental Studies Honors Theses

This thesis examines the politicization of greenhouse gas emissions within the American public, tracing its evolution from a consensus based scientific topic to a deeply polarized partisan issue. While early research established a clear link between greenhouse gases and global warming, the late 20th century saw a strategic rise in skepticism fueled by conservative think tanks, contrarian scientists, and industrial interests. This study analyzes the psychological mechanisms and media practices that have exacerbated this divide and decline in public environmental concern, which has resulted in negative social and environmental effects due to a slowed federal response to the climate crisis. …

Exploring Detached Concern, A Dual-Process Emotional-Regulation Strategy, Among Intensive Care Nurses Providing End-Of-Life Care In The United States, Melissa Milton Miasek

Dissertations

Intensive care unit (ICU) nurses repeatedly provide end-of-life care (EoLC) and experience significant emotional distress, burnout, and moral distress that can lead to leaving the profession. Detached concern (DC), a dual-process emotional-regulation strategy which balances empathetic concern with emotional detachment, may support ICU nurses' emotional well-being; however, DC among nurses remains vastly understudied. This qualitative descriptive study gained deeper understanding of DC among ICU nurses providing EoLC in the United States. The study was guided by a conceptual model adapting Lampert and Glaser's dynamic DC process within Elfenbein's emotional regulation framework. The overarching research question explored ICU nurses' perspectives on …

Icipe Annual Report 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a widespectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33 ) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (− 72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

Comparing Microgrids With Nuclear Energy: Which Is Better To Catapult New York Toward Its Green Energy Future?, Justin R. Ochs

Natural Resources Journal

This Note examines New York’s climate goals under the Climate Leadership and Community Protection Act (CLCPA) by comparing two pivotal energy solutions: nuclear energy and microgrids. Microgrids remain notably underexplored in legal scholarship, particularly their potential to achieve compliance with the CLCPA. By analyzing the economic, environmental, regulatory, and public perception challenges associated with nuclear energy and microgrids, this Note argues that microgrids offer a safer, more flexible, and sustainable option for accelerating New York’s path toward its green energy future. This Note evaluates microgrid projects across New York, along with common critiques regarding the scalability and viability of hybrid …

Andrews University Press 2026 Booklist, Andrews University Press

Booklists

No abstract provided.

Andrews University Press 2026 Booklist, Andrews University Press

Booklists

No abstract provided.

Sainik Vol 1 Issue 2, Sastra Deemed To Be University

SAINIK

No abstract provided.

Table Of Contents

FIU Law Review

No abstract provided.

The Law And Ai As An “Apex Collaborator”: Legal Frameworks For Optimized Cooperation, David S. Filippi, Bill Tomlinson, Andrew W. Torrance

FIU Law Review

Law fundamentally exists to enable human cooperation, providing frameworks for everything from basic contracts to complex international agreements. As artificial intelligence systems grow more sophisticated, they may enable new ways that collaborative activity can occur. We posit the possibility of a new kind of AI entity: the “Apex Collaborator,” a computational system with capabilities for cooperation and partnership that are superior, in at least some ways, to those of humans. Just as apex predators shape the ecosystems in which they live through predation, Apex Collaborators would shape human-AI networks through their ability to enhance peaceful coexistence, collective problem-solving, and shared …