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Perinatal Inflammation And Oxidative Stress Alter Adult Rat (Rattus Norvegicus) Motor Behavior, Alexander Young

Honors College Theses

Recent evidence in comparative animal models suggests that early life exposure to elevated inflammation (via LPS exposure) and oxidative stress (via acetaminophen exposure) may synergistically interact to alter typical neurodevelopmental trajectories, resulting in lasting effects on both behavior and gut-brain neurochemistry. The current study observed emotional and motor behaviors and collected fecal-boli to measure Tyrosine (TE) levels in male and female Long-Evans (Rattus norvegicus) rats. Subjects were either treated with [1] saline [2] lipopolysaccharide (LPS) to introduce an inflammatory state, [3] acetaminophen (APAP) to introduce oxidative stress, or [4] a dual-hit of both LPS + APAP on postnatal day (PD) …

Development Of Tunable Rose Bengal Based-Nanogumbos As Potential Selective Chemotherapeutic Agents, William J.A. Russell

Honors College Theses

As cancer remains one of the greatest threats to the global population, the development of chemotherapeutic agents that are selective and tunable is of critical importance. Herein, a series of Rose Bengal (RB)-based GUMBOS, a group of uniform materials based on organic salts, were synthesized via counterion exchange between [Na]₂[RB] and three organic cations: tetrabutylphosphonium bromide [TBP][Br], tetraphenylphosphonium chloride [TPP][Cl], and 1-dodecyl-3-methylimidazolium chloride [C₁₂MIm][Cl]. The resulting GUMBOS were characterized through FT-IR, ESI-MS, NMR, and UV-Vis Spectroscopy. Partition coefficient studies indicated all GUMBOS exhibited hydrophobic physiochemical characteristics. These hydrophobic RB-based GUMBOS …

Preventing Coccus Longulus Infestation, Nicholas Wellls

Honors College Theses

In the Armstrong greenhouse, the Coccus longulus scale insect is a prevalent problem on a specific species of Begonia known as Begonia ‘Richmondensis’. Inside the greenhouse there are several types of begonias with very similar characteristics to the Richmondensis begonia. However, none of these other begonias are infested by C. longulus, despite similar leaf thickness and environmental conditions such as humidity and light. This project examined whether differences in the chemical composition of the Begonia leaves can explain this pattern. Results were not statistically significant, but they showed that the chemicals had a noticeable impact on the scale, and …

Optimizing Healthy Aging: A Preventative Approach To Support Community-Dwelling Older Adults, Jada Welke

Occupational Therapy Capstones

Introduction: Healthy aging is a complex and multidimensional process influenced by physical, cognitive, psychosocial, environmental, and lifestyle factors across the lifespan. Increasing evidence from researchers suggests that many health care systems continue to rely on reactive models that address decline only after functional limitations emerge. Preventive interventions initiated in midlife have the potential to significantly influence long-term health outcomes, independence, well-being, and quality of life. As a result, there is growing recognition that multidimensional, proactive screening and intervention should begin earlier, before age-related conditions become clinically significant.

Purpose: The purpose of this scholarly project was to address this need through …

Achieving Successful Occupational Performance During Transitions In Eating Disorder Treatment, Elise Kay Ramberg

Occupational Therapy Capstones

Introduction: Individuals with eating disorders experience challenges in occupational engagement that stem from contributing meaning, value, and purpose to occupations that support eating disorder behaviors rather than promote quality of life (Mack et al., 2023). Recovery is highly dependent on the transition between both levels of care and back into the patient’s natural environment. Occupational therapists play an essential role in supporting patients as they transition and learn to re-engage in their lives outside of their eating disorder (Mack et al., 2023). The purpose of this project was to create materials for the occupational therapist to employ with eating disorder …

Cultivating Connections: Empowering Agricultural Community Members Through Collaborative Care, Kearyn E. Nelsen

Occupational Therapy Capstones

Background: Agriculture and mental health – two words not typically used in the same sentence; however, considering the rate of suicide among those working in the agriculture profession is significantly higher than the general population, the need for both awareness and action is critically important. Despite a lack of research specific to occupational therapy and the agricultural population, occupational therapists on an interprofessional healthcare team are uniquely positioned to serve this population. Interprofessional collaboration is essential when serving agricultural community members, whose needs involve a complexity of physical, mental, social, and environmental factors, each impacting the overall health and well-being …

Beyond Survival: Empowering Mental Health Recovery After Acquired Brain Injury, Paige Mackenzie Kozak

Occupational Therapy Capstones

Purpose: Individuals with acquired brain injury (ABI) frequently experience psychosocial and cognitive challenges, including depression, anxiety, emotional dysregulation, and identity changes which can significantly impact rehabilitation outcomes and participation in daily occupations. Despite this, outpatient rehabilitation clinicians may feel underprepared to recognize and address these concerns within their scope of practice. The purpose of this scholarly project was to develop an educational onboarding program to support interdisciplinary rehabilitation staff in identifying and responding to psychosocial needs of individuals with ABI, while promoting trauma-informed and patient-centered care.

Methodology: A literature review was conducted to examine common psychosocial and cognitive outcomes following …

Holistic Occupational Therapy Approach In Addressing Women’S Health Needs & Access To Care, Lilja Jurva

Occupational Therapy Capstones

Background: As women across the lifespan experience complex physical, emotional, and occupational challenges related to maternal transitions, mental health needs, chronic conditions, and rural healthcare disparities, occupational therapy is uniquely equipped to address the complex challenges. Services have been proven to be directly correlated to lower incidence of preterm birth, cesarean delivery, low birth weight, excessive gestational weight gain, diabetes mellitus, and hypersensitive disorders, and higher incidence of vaginal delivery. A clear gap for maternal support services was identified in the Grand Forks community through literature review, interviews, and community engagement, leading to the development of NoDak Therapy and Wellness. …

Empowering Caregivers: An Occupational Therapy-Informed Educational Program For Dementia Care In Rural Communities, Maria Lynn Johnson

Occupational Therapy Capstones

Purpose: Hospitalization presents significant risks for individuals with dementia, including increased behavioral and psychological symptoms (BPSD), delirium, functional decline, and reduced occupational engagement (Boltz et al., 2023; Teichmann et al., 2019; Zwingmann et al., 2020). Acute care environments are often overstimulating, unfamiliar, and task-oriented, which can exacerbate cognitive impairment and contribute to caregiver distress. Despite strong evidence supporting nonpharmacological, occupation-based interventions, structured engagement opportunities are rarely integrated into acute care workflows (Burgdorf et al., 2023; Faeder et al., 2023). This doctoral capstone project aimed to develop occupation-based dementia activities for use during hospitalization while equipping formal and informal caregivers with …

Family-Centered Programming For A Rural Midwest Emergency Shelter: An Occupational Lens, Ariel Kathryn Tix

Occupational Therapy Capstones

Introduction: After a period of decline in homelessness, a startling trend reversal occurred between 2023 and 2024; there was a 39% increase in families experiencing homelessness in the United States (de Sousa & Henry, 2024). Rural homelessness is less visible and often looks different from urban homelessness, which presents challenges that require a different approach (Brott et al., 2019). Individuals experiencing homelessness have challenges in every area of occupation and could benefit from novel strategies and resources. Challenges include parenting, accessing medical care, obtaining permanent housing, community mobility, and meaningful routine development (American Occupational Therapy Association, 2020; Brott et al., …

From Victim To Villain: How Gendered Narratives Shape Drug Courier Trials, Serafina C. Russo

Journal of Race, Gender, and Ethnicity

This article examines how gendered stereotypes, coercive trafficking dynamics, and permissive evidentiary practices create systemic bias in criminal prosecutions of women, particularly in drug trafficking cases. It highlights how courts often allow expert testimony and generalized narratives that blur neutral analysis with character judgment, inviting jurors to rely on cultural assumptions rather than objective facts. The “blind mule” phenomenon demonstrates the human cost, disproportionately affecting women from marginalized backgrounds, and reflects violations of due process and the presumption of innocence. The article argues for judicial and legislative reforms, including rigorous enforcement and clarification of Rule 704(b), to prevent stereotypes from …

Integrative Approaches And Data Analysis For Single-Cell Rna Sequencing Data, Teng Long

Computer Science and Engineering Dissertations

The rapid growth of single-cell RNA sequencing and transcriptomic datasets has created major computational challenges in causal discovery, representation learning, and biologically faithful data generation. To address these challenges, this dissertation presents three complementary deep learning frameworks for the analysis and modeling of transcriptomic data. Together, these methods form an integrative computational toolkit for understanding complex biological systems from high-dimensional and heterogeneous gene expression data.

First, this dissertation introduces DAG-VAERL, a causal discovery framework that integrates variational autoencoders, graph neural networks, reinforcement learning, and attention mechanisms to infer directed acyclic graphs for gene regulatory network analysis. DAG-VAERL improves causal structure …

2025-2026 University Awards Of Excellence, Georgia Southern University

University Awards of Excellence

• Innovation and Discovery
• Economic and Social Mobility
• People and Community Development
• Academic Excellence
• Collaboration and Partnership
• Leadership
• Sustainable Stewardship
• John D. and Merlyn J. Denitto Outstanding Endeavor Award
• Collective Impact

Mitochondria As Primary Cause Of Neurodegeneration: Evaluating Causality Across Amyotrophic Lateral Sclerosis (Als), Alzheimer's, And Parkinson’S Diseases, Makenzie G. Johnson

Undergraduate Honors Theses

Neurodegenerative diseases like Alzheimer's Disease (AD), Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) have historically been explained through alternate hypotheses despite shared clinical hallmarks that lead to neuron loss. However, these varying explanations could not account for how disease onset begins among other individual issues. This thesis aims to show that mitochondrial dysfunction is a primary driver of neurodegeneration as well as a unifying mechanism shared between the three diseases. Evidence presented in this thesis will show that many issues can arise in mitochondria including issues with energy production, mitochondrial DNA (mtDNA), apoptosis activation, and calcium regulation. These issues …

Dental Implantology: A Literature Review, Kylie Taylor

Undergraduate Honors Theses

Dental implant therapy is the process of replacing teeth as a form of treatment to improve quality of life, function, and esthetics. The success of the implant depends on the surgical technique, type of prosthetic, and factors related to individual patients. The most important factor for implant success is osseointegration. Osseointegration is a process in which success is determined by the bone quality, the surface characteristics of the implant and the surgical approach. Some approaches to improve the osseointegration of the implant are low-speed drilling, guided surgery, and reduced surgical trauma at the site. The impact of systemic conditions, health …

Murder Of The Magic Mushroom Man, Andrea Florian, Alexa Cabral, Olivia Fawkes, Emily Gomez

SPARK Symposium Presentations

Rowan Tucker is an heirloom vegetable farmer that lives in Newbury, VT on an 80-acre farm. Most of the money in Rowan’s name was from selling psilocybin mushrooms that he disguised as payments under “crop-selling”. He was found dead presenting symptoms early that morning of confusion, hallucinations, vomiting, sweating, and extreme salivation. How did he get murdered? Who did it?

A Day (Really Night) In The Life Of An Urban Raccoon, Grace K. Khalili, Sophia T. Concepcion, Darlene Panvini

SPARK Symposium Presentations

This project explores how urban environments shape the daily life, survival strategies, and ecological role of raccoons. Focusing on raccoons as non-human city residents, we examine their habitat use, feeding behaviors, and interactions with humans and other species. Using research articles, we highlight how raccoons adapt to urban spaces by using structures like trees, attics, and storm drains, and by relying on diverse food sources, including human waste. Our findings are presented as a children’s illustrated “day in the life” storybook, combining creative storytelling with urban ecology concepts. Overall, the project emphasizes raccoons’ adaptability and their important role in maintaining …

Dose-Dependent Developmental Toxicity Of Cisplatin In Zebrafish Embryos, Reagan D. Sellers, Katherine T. Doucet, Jinhee Park, Andrea Florian

SPARK Symposium Presentations

Cisplatin is a widely used chemotherapy drug for treating various types of cancer. Although cisplatin is effective in killing cancer, it can also cause toxic side effects in normal tissues. Because cisplatin can cross the placental barrier, its use during pregnancy is generally avoided, particularly during early embryonic stages of fetal development. Exposure to cytotoxic drugs during embryogenesis may lead to developmental abnormalities, birth defects, or pregnancy complications. Understanding how cisplatin affects early development is therefore important.          
       Zebrafish (Danio rerio) are an established model for studying developmental toxicity due to their rapid external development, transparent embryos, and genetic similarity to …

Effects Of Glucagon And Insulin On Sw480 Colorectal Cancer Cells In Combination With Cisplatin, Sarah M. Gabous, Andrea Florian

SPARK Symposium Presentations

Colorectal cancer is known to be one of the most common forms of cancer in the world. Over time, treatment responses are affected by various metabolic changes along with chemotherapies. Glucagon signaling and Insulin are linked to colorectal cancer and have also been shown to affect tumor growth, as well as the chemotherapy drug response.In this experimental study, the purpose was to determine whether glucagon and insulin decrease the viability of SW480 colorectal cancer cells during cisplatin (CDDP) treatment. CRC cells were treated with cisplatin alone and in combination with either glucagon or insulin, and cell viability was measured to …

Fisheries Research Report No. 359: Metropolitan Monitoring Program 2025, Alissa Tate, Claire B. Smallwood, Karina L. Ryan, Troy Matthews

Fisheries Research Reports

Ongoing monitoring of recreational fisheries in the Perth Metropolitan zone is essential to ensure the sustainable use of fisheries resources. Surveys of shore- and boatbased recreational fishers within the Metropolitan zone of the West Coast bioregion provide information on human dimensions and catch-per-fisher as well as mean length and weight of key recreationally caught species. For shore-based fishers, estimates of fishing effort, catch and harvest are also presented for key nearshore species. This information is used to support ongoing assessments for key nearshore species and the development and evaluation of harvest strategies and other management actions, such as for Australian …

Altered Natural Killer Cell Function In Children With Severe Malaria, Grace Turyasingura, Kagan A. Mellencamp, Ruth Namazzi, Robert Opoka, Chandy C. John, Geoffrey T. Hart

Paediatrics and Child Health, East Africa

Memory-like natural killer (NK) cells with enhanced antibody-dependent cellular cytotoxicity (ADCC) have correlated with protection from uncomplicated malaria in prior studies. However, the role of NK cells in severe malaria (SM) has not been characterized. In Ugandan sites with moderate and low malaria transmission, we evaluated NK cell (CD56bright, CD56dim, CD56neg) phenotype and ADCC function by flow cytometry in children < 5 years of age with SM (n = 21) and control community children (CC, n = 19). Children with SM had similar total NK cell counts to CC. Children with SM had a higher proportion of LILRB1+ NK cells than CC. The level of malaria transmission …

Sjsu Erfa News, Winter 2026, San Jose State University, Emeritus And Retired Faculty Association

Emeritus and Retired Faculty Association (ERFA) Newsletter

Volume 39, No 2

(Trans*)Gressing Discourse: Producing And Disrupting Normativity In Education For Trans* Students With Dis/Abilities, Meagan Meredith

Educational Leadership & Policy Studies Dissertations - Archive

This dissertation investigates how political rhetoric, education policy, and educational community member discourse construct, circulate, and contest meanings about trans*ness and dis/ability in K-12 public schools. In doing so, the study examines how meanings about normativity are discursively produced and disrupted for students living at this specific intersection. Grounded in a trans* methodology, this study performs a critical discourse analysis through a rhizomatic reading of policy texts, political rhetoric, and publicly available stakeholder discourse. This work responds to a gap in the literature that fails to understand the complexities experienced by trans* students with dis/abilities, particularly in hostile school climates. …

Hostos Community College Academic Bulletin 2025-2026, Hostos Community College

College Bulletins

This is the official college catalog for 2025-2026. It contains course descriptions as well as information on degree programs, college resources and services, financial aid, admissions, and the academic calendar.

Elevated Bmi And The Effect On Breastfeeding Duration In Postpartum Individuals: An Integrative Review, Abigail E. Mobilia, Kirstin A. Wyly

All Electronic Theses and Dissertations

Introduction: It has been well documented that exclusive breastfeeding provides benefits for infants and postpartum individuals, yet rates remain suboptimal in the United States, particularly among those with elevated pre-pregnancy body mass index (BMI). Evidence suggests that elevated BMI is associated with shorter breastfeeding duration and may be influenced by physiologic, social, and structural factors. This integrative review synthesizes existing literature to clarify the relationship between elevated BMI and exclusive breastfeeding duration among postpartum individuals.
Methods: An integrative review was conducted following Whittemore and Knafl’s (2005) framework and PRISMA 2020 guidelines. A systematic search of PubMed, CINAHL, and Nursing & …

Gestational Diabetes Mellitus And Its Psychological Impacts During Pregnancy And Postpartum, Nehemie B. Hypolite, Charline Fast

All Electronic Theses and Dissertations

Introduction: This review explores the link between gestational diabetes (GDM) and psychological outcomes. GDM affects 8–10% of pregnancies and is typically diagnosed at 24–28 weeks. This burden leads to anxiety, depression, and fear. Postpartum concerns often persist for mother and infant.

Methods: Whittemore and Knafl’s (2005) method was used to synthesize data. The research databases included CINAHL and PubMed. Covidence supported screening and PRISMA diagram development. Key search terms included “anxiety and GDM,” “depression and GDM,” “GDM and postpartum depression,” “gestational diabetes,” and “pregnancy.” Inclusion criteria included full-text articles published after 2010, original studies, patients undergoing diabetic treatment (medication and/or …

The Impact Of Patient-Centered Care On Women With Infertility And Pregnancy Loss: An Integrative Review, Kaidynce R. Sweazy

All Electronic Theses and Dissertations

Introduction: Infertility affects roughly 17.5% of adults worldwide, while pregnancy loss occurs in up to 30% of pregnancies. These reproductive traumas increase the risk of developing a mental health disorder, such as anxiety, depression, or post-traumatic stress disorder (PTSD). The purpose of this review is to identify the influence of patient-centered care on psychological outcomes and experiences of care in women with infertility and pregnancy loss.
Methods: A literature search of the PubMed and Cinahl databases was conducted for original studies published from January 2016 to January 2026 that address the psychological outcomes and/or experiences of women who experienced infertility …

How Gender Differences Influence The Presentation, Diagnosis, And Lived Experience Of Females With Autism Spectrum Disorder, Casey A. Vanyo

All Electronic Theses and Dissertations

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a highly variable presentation influenced by gender. Historically, autism research has focused primarily on males, contributing to the under recognition and misdiagnosis of girls, women, and gender-diverse individuals. Women engage in camouflaging behaviors to align with social expectations, which can mask autistic traits and contribute to higher levels of anxiety, depression, and emotional exhaustion. This thesis examines how gender shapes the presentation, diagnosis, and lived experiences of autistic females. It explores differences in diagnostic practices, mental health outcomes, and access to support. Findings suggest that current frameworks often fail to capture …

A Critical Discourse Analysis Of Racial Justice In Virginia Higher Education, Abigail Green

Honors Theses

This honors thesis examines the extent to which public Virginia higher education institutions engage their institutional histories in leadership rhetoric when responding to the Trump administration’s anti-diversity, equity, and inclusion (DEI) policies. Employing a Critical Discourse Analysis (CDA) following Mullet’s (2018) seven-step framework with an inductive coding approach and grounded in rhetorical history theory, this study analyzes official statements from the Offices of the President and Provost across four case study institutions: the University of Virginia (UVA), George Mason University (GMU), the College of William & Mary (W&M), and Longwood University (LU). Data sources span two time periods: May 2020 …

Crafting The “Greatest Classics” Of Girlhood: Advice Columns, Diaries, And The Emotional Lives Of American Teenage Girls, 1918-1939, Kylee Violet King

Honors Theses

“Crafting the ‘Greatest Classics’ of Girlhood: Advice Columns, Diaries, and the Emotional Lives of American Teenage Girls, 1918-1939” explores how American teenage girls who came of age between 1918 and 1939 used writing as a form of expression. As a response to the heightened anxieties—the “storm and the stress”—that was caused by the social structure of the era, teenage girls used writing in advice column letters and diaries as a form of self-fashioning, self-reflection, and self-therapy to discuss courtship, dating, and romantic relationships. Additionally, depending on the medium, writing acted as a form of advice seeking and community support. Writing …