Digital Commons Network^™

Phase 1 Open-Label Study Of Asp9801, An Oncolytic Virus, In Patients With Advanced Or Metastatic Solid Tumors, John L. Villano, Jason J. Luke, Ricklie Julian, Christos Fountzilas, Manish R. Patel, Michael J. Chisamore, Pranob Bhattacharya, Shigeru Takeshita, Serguei Soukharev, Shunsuke Yamada, Leshi Zhang, Kristopher P. Wentzel

Neurology Faculty Publications

Purpose ASP9801, an oncolytic virus encoding interleukin-7 and interleukin-12, was assessed for safety, tolerability, pharmacokinetics, and antitumor activity in patients with advanced solid tumors in a Phase 1 study. Methods The study comprised Part 1 ASP9801 monotherapy dose escalation and Part 2 dose expansion with ASP9801 monotherapy or plus pembrolizumab. Each part was divided into Groups A (ASP9801 injection into cutaneous/subcutaneous lesions) and B (ASP9801 injection into visceral lesions). Primary objectives were safety and maximum tolerated dose and/or recommended Phase 2 dose expansion (RP2D); secondary objectives included antitumor activity and pharmacokinetics. Results In dose escalation, 17 and 10 patients in …

Noninvasive Patient-Level Detection Of Nafld Using Mri Radiomics And Machine Learning, Vladimir Kirichenko, Rajanikanth Vadigepalli

Phase 1

Introduction— Current noninvasive assessment of nonalcoholic fatty liver disease (NAFLD) relies primarily on MRI-based fat quantification, such as proton density fat fraction (PDFF). This study explored the use of an MRI radiomics–based machine learning approach for accurate patient-level classification of NAFLD.

Methods— Liver MRI images from patients with suspected NAFLfD were retrospectively analyzed. Radiomics features were extracted using PyRadiomics from full-liver masks across 4–6 axial slices per patient. Slice-level features were aggregated to the patient level using summary statistics (mean, median, and standard deviation). To reduce redundancy and multicollinearity, features were pruned using Pearson correlation analysis with a threshold of …

The Correlation Between Pain And Placement Of The Jackson-Pratt Drain In Post-Mastectomy Patients, Krishna Koka, Bs, Elizabeth Simon, Bs, Spencer Haber, Bs, Devin Williams, Bs, Andrew Newman, Md

Phase 1

Introduction

The Jackson-Pratt Drain is a frequently used closed-suction, active drain system that prevents seroma and hematoma formation through negative pressure drainage. Prior research has revealed that some patients report increased surgical site pain that negatively impacts quality of life. We hypothesize that interpatient variability in pain may be associated with the location of drain placement relative to local innervation.

Methods

We are targeting 30 biologically female patients >30 years old undergoing bilateral mastectomy, excluding those with factors affecting chest wall innervation. Drain placement was measured bilaterally along an X-Y axis: X from the mid-axillary line (negative medial, positive lateral) …

"The Persistent And Muddy Dispute": How The Facial/As-Applied Distinction Creates Problems For Constitutional Litigants, Sean P. Wilson

Duke Law Journal

The distinction between facial and as-applied challenges continues to play a central role in constitutional litigation, including at the Supreme Court. Yet, the distinction and its related rules have long suffered from a lack of doctrinal clarity and consistency. This Note sets out a descriptive taxonomy of three problems facing constitutional litigants because of the murkiness surrounding the facial/as-applied distinction.

First, the “Doctrinal-Test Problem” refers to the fact that many constitutional doctrines appear to require the courts to engage in facial adjudication, even if a litigant wishes to bring an as-applied claim. Thus, as-applied litigants are forced into facial challenges, …

Association Between Environmental Exposures To Perfluoroalkyl And Polyfluoroalkyl Substances And Military Veterans Cancer Determination, Stephen A. Pereira Jr

Walden Dissertations and Doctoral Studies

This study involved evaluating whether cumulative exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) was associated with kidney cancer, bladder cancer, and adult leukemia among U.S. veterans. Pooled National Health and Nutrition Examination Survey (NHANES) data from 2005–2015 were analyzed for sample of 2,500 veterans with available serum PFAS measurements and physician-diagnosed cancer histories. This study employed a cross-sectional, correlational design grounded in a post-positivist paradigm. Inclusion required complete data for (a) serum PFAS concentrations, (b) kidney cancer, bladder cancer, and adult leukemia, and (c) covariates age, sex, race/ethnicity, smoking status, and body mass index. Cumulative PFAS was modeled as a …

Understanding Reporting Decisions: Qualitative Exploration Of Hate Crime Underreporting Among Minority Transgender Individuals, Shanise Anita Benitez

Walden Dissertations and Doctoral Studies

Minority transgender individuals experience disproportionately high rates of hate‑motivated violence, yet these incidents remain substantially underreported. This qualitative study examined the social, structural, and identity‑based factors that influence reporting decisions among minority transgender adults in the United States. Guided by Bandura’s social learning theory and Crenshaw’s intersectionality theory, the study examined how participants’ lived experiences, community-based observations, and intersecting marginalized identities influence their perceptions of safety, trust, and institutional legitimacy. Semi‑structured interviews with minority transgender participants were analyzed using thematic analysis to identify patterns related to reporting behaviors, community‑driven coping strategies, and barriers to formal engagement with law enforcement. Findings …

Agent-Based Model Details For Quantifying Error In Drone-Based Animal Surveys: Animal Density, Distribution And Flight Patterns, Emma A. Schultz, Natasha Ellison-Neary, Landon R. Jones, Kristine O. Evans, Raymond B. Iglay

Research Data

The following dataset pertains to Python scripts of an agent-based model simulating various drone survey design and quantifying potential count bias of stationary animals in fixed landscapes as part of an accepted manuscript in Ecosphere. Simulated animals were distributed among five animal densities (n = 4, 9, 25, 49, 100 animals/survey area) and three distribution patterns (random, uniform, aggregated). Eight drone flight patterns surveyed a 4.16-km² landscape within constraints of real-world battery and line-of-sight limitations. The simplified landscape also provided 100% animal classification (i.e., all animals within image frame observed and identified).

Linking Local Ecological Knowledge And Management Perspectives On Oyster Predation In Mississippi And Alabama, Cynthia Lupton, Eric Sparks, Mark Woodrey, James M. Drymon, Nigel Temple, Steven Scyphers

Research Data

Eastern oysters (Crassostrea virginica) provide critical ecosystem services, yet populations along the northern Gulf Coast are declining due to environmental stressors, such as water quality issues and predation. To evaluate how threats to oysters are perceived across stakeholder groups, we surveyed oyster Farmers and Resource professionals in Mississippi and Alabama about predator impacts, seasonal patterns, and mitigation strategies. Survey responses (n = 21) were analyzed using descriptive statistics, Fisher’s Exact tests, Mann–Whitney U tests, and t-tests. Farmers and Resource professionals identified multiple predators as important sources of mortality, but their relative rankings differed across groups. Resource professionals consistently viewed southern …

Identification Of Gene Signatures Of Metabolic Dysfunction-Associated Steatotic Liver Disease In Patients With Pancreatic Ductal Adenocarcinoma Via Whole Transcriptome Sequencing, Chaitanya Karimanasseri Bse, Pongsakorn Choochuen Md, Phd, Yotsawat Pomyen Phd, Hien Dang Phd

Phase 1

Introduction
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality worldwide. While the only curative treatment for PDAC is surgical excision of the tumor, often surgery is ineffective due to early metastasis to other organs. A better understanding of PDAC’s risk factors would contribute to earlier PDAC diagnoses and thus more effective surgical resections before metastasis occurs.

One pathology related to PDAC is metabolic dysfunction-associated steatotic liver disease (MASLD), a metabolic disease leading to triglyceride accumulation in the liver. MASLD is known to cause worse PDAC outcomes versus non-MASLD PDAC. Further elucidating the mechanism through which MASLD increases …

Agent-Based Modeling Of Cellular Dynamics In Adoptive Cell Therapy, Yujia Wang, Stefano Casarin, May Daher, Vakul Mohanty, Merve Dede, Mayra Shanley, Eleonora Dondossola, Ludovica La Posta, Rafet Başar, Katayoun Rezvani, Ken Chen

Faculty, Staff and Student Publications

Adoptive cell therapies (ACT) leverage tumor-immune interactions to cure cancer. Despite promising phase I/II clinical trials of chimeric-antigen-receptor natural killer (CAR-NK) cell therapies, molecular mechanisms and cellular properties required to achieve clinical benefits in broad cancer spectra remain underexplored. While in vitro and in vivo experiments are essential, they are expensive, laborious, and limited to targeted investigations. Here, we present ABMACT (Agent-Based Model for Adoptive Cell Therapy), an in silico approach employing agent-based models (ABM) to simulate the continuous course and dynamics of an evolving tumor-immune ecosystem, consisting of heterogeneous "virtual cells" created based on knowledge and omics data observed …

Precision Chemotherapy In Biliary Tract Cancer Moving From Empiric Intensification To Biomarker-Guided Treatment: Editorial On "Molecular Determinants Of Outcome To Gemcitabine, Cisplatin, And Nab-Paclitaxel In Patients With Advanced Btc", Sung Hwan Lee, Ahmed O Kaseb, Ju-Seog Lee

Faculty, Staff and Student Publications

No abstract provided.

Prevalence Of Premenstrual Syndrome, Premenstrual Dysphoric Disorder, And Dysmenorrhea In Nursing Students: A Systematic Review, Meta-Analysis, And Evidence-Based Recommendations, Sabyasachi Maity, Bharathi Gadad, Hansapani Rodrigo, Seham Noorani, Ayesha Usman, Chloe Lark, Mona Attarpour, Ivy Mageto, Lucas Schwartz, Nikhilesh Anand

School of Medicine Publications

Introduction: Menstrual disorders—including premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and dysmenorrhea—are highly prevalent among women of reproductive age and are associated with impaired academic performance, psychological distress, and reduced social functioning. Nursing students are particularly vulnerable due to the combined demands of intensive academic schedules and clinical training, yet prevalence estimates and institutional responses remain inconsistent.

Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD420251109363). PubMed, Scopus, Web of Science, CINAHL Ultimate, and APA PsycINFO were searched for studies published between 2016 and 2025. Eligible studies reported prevalence or …

Bioprinting: Revolutionizing Biology With 3d Innovation, Gopalarethinam Janani Ms, Naven Kumar Rk, Agnishwar Girigoswami Prof, Koyeli Girigoswami Prof

Chulalongkorn Medical Journal

3D bioprinting is an innovative technology that enables the creation of bioengineered structures through computer-guided processes. This technique has been in use for more than 35 years and has made a huge contribution in the biomedical field. Utilizing biomaterials with regenerative properties has significantly impacted tissue engineering, regenerative medicine, and pharmaceutical research. Various bioprinting techniques, including inkjet, extrusion, laser-assisted, and stereolithography, offer unique advantages for precise tissue construction. Bioinks used for printing, can be derived from natural and synthetic sources. It ensures biocompatibility, mechanical integrity, and controlled degradation. Advanced bioinks—such as nanoengineered, biomolecular, multimaterial, self-assembling, and stimuli-responsive variants—enhance applications in …

Elucidation Of Hub Genes And Pathway Associated With Gut Microbiome Dysbiosis And Alzheimer’S Disease Via Data Analytic Approaches, Premaanand Rawi, Ying Pei Wong, Ee Xion Tan, Anna Pick Kiong Ling

Chulalongkorn Medical Journal

Background: Recent studies have highlighted the relationship between gut microbiome and Alzheimer’s disease (AD), revealing the ways of how gut microbial balance impacts conditions ranging from inflammatory bowel diseases to neurological disorders. The emerging field of the gut-brain-axis suggests production of microbial metabolites influences AD progression. However, there is limited understanding of molecular mechanisms involved in neurological disease when gut microbiome dysbiosis occurs. This study aimed to identify hub genes and pathways associated with gut microbiome dysbiosis and AD through data analytics approaches.

Methods: Public gene expression datasets on gut microbiome dysbiosis, and AD were obtained from the GEO and …

New Century, Natalie Goldberg

Creative Nonfiction Magazine

No abstract provided.

Money For Nothing, Kevin Holdsworth

Creative Nonfiction Magazine

No abstract provided.

Magnesium Intake And Periodontal Health In Adults, Dana Faghih, Man Hung, Amir Mohajeri

Annual Research Symposium

No abstract provided.

From Image To Chairside Decision-Making: Unsupervised Morphological Clustering Of Carious Lesions Aligned With Clinical Severity, Bailey Axelrad, Shilpa Bhandi, Shankargouda Patil, Sydney Sorensen

Annual Research Symposium

No abstract provided.

Computational Network Biology Of Host Microbe Crosstalk In Persistent Endodontic Inflammation, Janaki O’Callaghan, Shilpa Bhandi, Shankargounga Patil, Frank W. Licari

Annual Research Symposium

Persistent endodontic infections can endure despite technically adequate root canal treatment, reflecting a biological transition from microbial invasion to a host-driven chronic inflammatory state. This study applied a computational network biology approach to model host–microbe molecular interactions in chronic apical periodontitis and to identify key network hubs sustaining inflammation and periapical bone resorption.

Mississippi Libraries Volume 87, Number 3 And 4

Mississippi Libraries

Complete issue of Volume 87, Number 3 and 4 of Mississippi Libraries.

News Briefs, Marvin H. Jeter Iii, Joyce Shaw

Mississippi Libraries

News updates from Gunter Library at the Gulf Coast Research Laboratory and from the Mississippi Library Commission.

Gray Area: Thinking With A Damaged Brain, Floyd Skloot

Creative Nonfiction Magazine

No abstract provided.

Notes From A Difficult Case, Ruthann Robson

Creative Nonfiction Magazine

No abstract provided.

Shunned, Meredith Hall

Creative Nonfiction Magazine

No abstract provided.

Attachment In Adolescents: Exploring Influential Factors In High School Students, Nurşen Korkmaz, Emine Altun Yılmaz

Journal of Child Science

This descriptive cross-sectional study was conducted with 584 students aged 14-18 attending high school in Tokat province in the 2023-2024 academic year in order to determine attachment and influencing factors in high school students. Data collection tools included a Descriptive Information Form and the Inventory of Parent and Peer Attachment (IPPA). Data were analyzed on the SPSS 24.0 software by using descriptive statistics, t-test, One-Way ANOVA, Mann-Whitney U, and Kruskal-Wallis tests. Of the students, 29.6% were 12th-graders, 28.9% were 17 years old, and 55.8% were female. Participants’ mean score was 66.23±12.92 on the attachment to the mother sub-dimension, 58.84±16.03 on …

Maternal Weight Trajectories From Pre-Pregnancy Through Postpartum And Childhood Obesity Risk At 24 Months Of Age: A Group-Based Trajectory Modeling Analysis, Taniqua T. Ingol, Sarah E. Anderson, Joseph Rausch, Rebecca Andridge, Bharathi J. Zvara, Sarah A. Keim

Journal of Child Science

Background: High pre-pregnancy BMI, excessive gestational weight gain, and postpartum weight retention are modifiable risk factors for childhood obesity, but are often studied singly, limiting understanding of their combined impact. Our objective was to characterize maternal weight trajectories across pregnancy until 18 months’ postpartum and examine associations with child overweight or obesity. Methods: We analyzed data from 299 mother-child dyads enrolled in the Play & Grow study (Ohio, USA). Mother’s weight and height were measured at study enrollment at 18 months’ postpartum. Pre-pregnancy weight and height and weight at delivery were obtained through linkage to birth certificate data. Group-based trajectory …

Aquatic Interrelations In Malika Mokeddem’S Novel N’Zid (2001), Laura C. Klein

Green Humanities: A Journal of Ecological Thought in Literature, Philosophy & the Arts

This article offers an ecological analysis of Malika Mokeddem's novel N'Zid (2001), moving beyond postcolonial and anthropocentric interpretations. It centers on the protagonist Nora's individuation, arguing this process is intrinsically linked to her evolving relationship with the aquatic environment from which she emerges. The article aims to situate N'Zid within an ecological perspective, particularly relevant in the Anthropocene, an era compelling a reassessment of humanity's place. Echoing Bruno Latour, addressing inter-relationality is essential as the stable physical framework of the Moderns becomes unstable. This view necessitates rethinking environmental issues and encourages a scientific interpretation of the novel, drawing on neurosciences, …

In The Science Library, Madeleine Wattenberg

Green Humanities: A Journal of Ecological Thought in Literature, Philosophy & the Arts

No abstract provided.

Volume 5 - Water (Full)

Green Humanities: A Journal of Ecological Thought in Literature, Philosophy & the Arts

No abstract provided.

Wildearth Guardians V. U.S. Dept. Of Agric. Animal And Plant Health Inspection Serv. Wildlife Services, Luke A. Zagar

Public Land & Resources Law Review

WildEarth Guardians v. U.S. Dept. of Agric. Animal and Plant Health Inspection Serv. Wildlife Services considers whether Predator Damage Management (“PDM”) programs in Wilderness Areas violate the Wilderness Act and whether the United States Department of Agriculture’s Animal and Plant Health Inspection Service, Wildlife Services (“Wildlife Services”) violated the National Environmental Policy Act (“NEPA”) in issuing its Final Environmental Assessment (“EA”) and Finding of No Significant Impact (“FONSI”). The Court of Appeals for the Ninth Circuit affirmed its prior holding in Forest Guardians v. Naimal & Plant Health Inspection Serv., finding that “the Wilderness Act does not prohibit Wildlife Service …